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Ibrahim Saana Amiinu, Jian Zhang, Zongkui Kou, Xiaobo Liu, Owusu Kwadwo Asare, Huang Zhou, Kun Cheng, Haining Zhang, Liqiang Mai, Mu Pan, Shichun Mu
3D graphene-based materials offer immense potentials to overcome the challenges related to the functionality, performance, cost, and stability of fuel cell electrocatalysts. Herein, a nitrogen (N) and sulfur (S) dual-doped 3D porous graphene catalyst is synthesized via a single-row pyrolysis using biomass as solitary source for both N and S, and a structure directing agent. The thermochemical reaction of biomass functional groups with graphene oxide facilitates in situ generation of reactive N and S species, stimulating the graphene layers to reorganize into a trimodal 3D porous assembly...
October 14, 2016: ACS Applied Materials & Interfaces
Ei-Ichiro Takaoka, Jun Miyazaki, Hitoshi Ishikawa, Koji Kawai, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Reiko Kanuma, Daichi Takizawa, Toshiyuki Okumura, Hideyuki Sakurai, Hiroyuki Nishiyama
OBJECTIVE: We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving therapy for muscle-invasive bladder cancer at our institution. METHODS: From 1990 to 2015, 70 patients with cT2-3N0M0 muscle-invasive bladder cancer underwent trimodal bladder-preserving therapy consisting of maximal transurethral resection of the bladder tumor, small pelvis photon irradiation, intra-arterial chemotherapy and proton beam therapy...
October 13, 2016: Japanese Journal of Clinical Oncology
Kimberley S Mak, Angela B Smith, Alec Eidelman, Rebecca Clayman, Andrzej Niemierko, Jed-Sian Cheng, Jonathan Matthews, Michael R Drumm, Matthew E Nielsen, Adam S Feldman, Richard J Lee, Anthony L Zietman, Ronald C Chen, William U Shipley, Matthew I Milowsky, Jason A Efstathiou
PURPOSE: Health-related quality of life (QOL) has not been well-studied in survivors of muscle-invasive bladder cancer (MIBC). The present study compared long-term QOL in MIBC patients treated with radical cystectomy (RC) versus bladder-sparing trimodality therapy (TMT). METHODS AND MATERIALS: This cross-sectional bi-institutional study identified 226 patients with nonmetastatic cT2-cT4 MIBC, diagnosed in 1990 to 2011, who were eligible for RC and were disease free for ≥2 years...
August 24, 2016: International Journal of Radiation Oncology, Biology, Physics
Sarah J Gao, Christopher D Corso, Elyn H Wang, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Roy H Decker, Anthony W Kim
INTRODUCTION: A subset of patients with potentially resectable clinical stage IIIA non-small cell lung cancer (NSCLC) are managed with trimodality therapy. However, little data exist to guide the timing of surgery after neoadjuvant therapy. This study examined whether the time interval between neoadjuvant chemoradiation (NCRT) and surgical resection impacts overall survival. METHODS: Clinical stage IIIA disease (T1-3 N2) NSCLC patients who underwent neoadjuvant chemoradiation therapy were identified in the National Cancer Data Base (NCDB) between 2004-2012 and categorized based on the interval between chemoradiation and surgery (0 to ≤3, 3 to ≤6, 6 to ≤9, and 9 to ≤12 weeks)...
October 5, 2016: Journal of Thoracic Oncology
Sam Wouters, Tom Hauffman, Marjo C Mittelmeijer-Hazeleger, Gadi Rothenberg, Gert Desmet, Gino V Baron, Sebastiaan Eeltink
Poly(styrene-co-divinylbenzene) monolithic stationary phases with two different domain sizes were synthesized by a thermally initiated free-radical copolymerization in capillary columns. The morphology was investigated at the meso- and macroscopic level using complementary physical characterization techniques aiming at better understanding the effect of column structure on separation performance. Varying the porogenic solvent ratio yielded materials with a mode pore size of 200 nm and 1.5 μm, respectively...
October 5, 2016: Journal of Separation Science
C Dickhoff, K J Hartemink, J Kooij, P M van de Ven, M A Paul, E F Smit, M Dahele
No abstract text is available yet for this article.
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Andrea L Arnett, Ann T Packard, Yolanda I Garces, Kenneth W Merrell
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
H Kim, Y C Ahn, H R Pyo, D Oh, J M Noh, M J Ahn, K Park, J Kim, J I Zo, Y M Shim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
P Kumar, P Veldhuizen, M Thompson, X Shen, J Pinski
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
S L Lu, F M Hsu, C L Tsai, J M Lee, P M Huang, C H Hsu, C C Lin, Y L Chang, M S Hsieh, J C H Cheng
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Ashley B Simpson, Devina McCray, Craig Wengler, Joseph P Crowe, Risal Djohan, Rahul Tendulkar, Colin O'Rourke, Stephen R Grobmyer, Stephanie A Valente
BACKGROUND: Inflammatory breast cancer (IBC) is an aggressive disease that is treated with trimodality therapy consisting of neoadjuvant chemotherapy, surgery, and post-mastectomy radiation therapy (PMRT). Traditionally, modified radical mastectomy without reconstruction has been the operation of choice for patients with IBC due to fears of high rates of margin positivity, risk of local recurrence, and the need for PMRT. METHODS: A retrospective review was performed to evaluate women with IBC at our institution from 2006 to 2014 who completed trimodality therapy...
September 8, 2016: Annals of Surgical Oncology
A Vilquin, J F Boudet, H Kellay
Velocity distributions in normal shock waves obtained in dilute granular flows are studied. These distributions cannot be described by a simple functional shape and are believed to be bimodal. Our results show that these distributions are not strictly bimodal but a trimodal distribution is shown to be sufficient. The usual Mott-Smith bimodal description of these distributions, developed for molecular gases, and based on the coexistence of two subpopulations (a supersonic and a subsonic population) in the shock front, can be modified by adding a third subpopulation...
August 2016: Physical Review. E
Silviu I Buderi, Michael Shackcloth, Richard D Page
A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was whether trimodal therapy [neoadjuvant chemoradiotherapy (nCRT) in addition to surgery] improves survival in patients with resectable oesophageal cancer. Altogether 565 studies were identified using the below-mentioned search. Eleven represented the best evidence to answer the clinical question. The author, journal, date and country of publication, patient group, relevant outcomes and weaknesses are tabulated...
September 13, 2016: Interactive Cardiovascular and Thoracic Surgery
Yue-Can Zeng, Shilpa Vyas, Quang Dang, Lindsay Schultz, Stephen R Bowen, Veena Shankaran, Farhood Farjah, Brant K Oelschlager, Smith Apisarnthanarax, Jing Zeng
PURPOSE: The aim of this study is to present the dosimetry, feasibility, and preliminary clinical results of a novel pencil beam scanning (PBS) posterior beam technique of proton treatment for esophageal cancer in the setting of trimodality therapy. METHODS: From February 2014 to June 2015, 13 patients with locally advanced esophageal cancer (T3-4N0-2M0; 11 adenocarcinoma, 2 squamous cell carcinoma) were treated with trimodality therapy (neoadjuvant chemoradiation followed by esophagectomy)...
September 5, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Brian P Chen, Rashami Awasthi, Shane N Sweet, Enrico M Minnella, Andreas Bergdahl, Daniel Santa Mina, Francesco Carli, Celena Scheede-Bergdahl
PURPOSE: High complication rates following colorectal surgery render many patients unable to fully regain functional capacity, thus seriously compromising quality of life. The aim of this study was to assess whether a 4-week trimodal prehabilitation program (exercise, nutritional supplementation, and counseling on relaxation techniques), implemented during the preoperative period, is sufficient to modify exercise behaviors and improve functional capacity of elderly patients scheduled for colorectal cancer surgery...
August 18, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
C Ramos, M Montaño, G González, F Vadillo, M Selman
In spite of several studies, both in vivo and in vitro, the pathogenesis of silicosis remains unclear, mainly in those mechanisms related to fibrogenesis. In this study, we analyzed the concentration, biosynthesis, and degradation of collagen in silica-treated rats 7, 15, 30, 45, and 60 days after instillation. Our results showed a significant increase in collagen content and biosynthesis from the 15th day onward. However, our most remarkable finding was related to collagenolytic activity. In this sense, the silicotic rats presented a trimodal behavior: some animals showed an increased degradation, others had similar values to those of the controls, and others exhibited a decrease of collagenolytic activity...
December 1988: Lung
B M Warpe, A V Shrikhande, S V Poflee
BACKGROUND: Until now, trimodal distribution of HbS has been seen by six different studies in the world when associated with alpha-thalassemia with confirmation by corresponding alpha-genotyping studies. The RBC indices reduce as alpha-globin genes reduce in sickle cell trait (SCT) patients, which decreases the extent of intra-vascular sickling and thus betters the clinical course of the patients. This is a pioneer study conducted on Central Indian poor population to use the already proven six studies to screen associated alpha-thalassemia in SCT patients thus, circumventing the much costlier alpha-genotyping studies...
2016: Iranian Journal of Pathology
Henrik Cordes, Christoph Thiel, Hélène E Aschmann, Vanessa Baier, Lars M Blank, Lars Kuepfer
Due to its high early bactericidal activity, isoniazid (INH) plays an essential role in tuberculosis treatment. Genetic polymorphisms of N-acetyltransferase type 2 (NAT2) cause a trimodal distribution of INH pharmacokinetics in slow, intermediate, and fast acetylators. The success of INH-based chemotherapy is associated with acetylator and patient health status. Still, a standard dose recommended by the FDA is administered regardless of acetylator type or immune status, even though adverse effects occur in 5 to 33% of all patients...
October 2016: Antimicrobial Agents and Chemotherapy
Tzu-Yin Lin, Yuanpei Li, Qiangqiang Liu, Jui-Lin Chen, Hongyong Zhang, Diana Lac, Hua Zhang, Katherine W Ferrara, Sebastian Wachsmann-Hogiu, Tianhong Li, Susan Airhart, Ralph deVere White, Kit S Lam, Chong-Xian Pan
The overall prognosis of bladder cancer has not been improved over the last 30 years and therefore, there is a great medical need to develop novel diagnosis and therapy approaches for bladder cancer. We developed a multifunctional nanoporphyrin platform that was coated with a bladder cancer-specific ligand named PLZ4. PLZ4-nanoporphyrin (PNP) integrates photodynamic diagnosis, image-guided photodynamic therapy, photothermal therapy and targeted chemotherapy in a single procedure. PNPs are spherical, relatively small (around 23 nm), and have the ability to preferably emit fluorescence/heat/reactive oxygen species upon illumination with near infrared light...
October 2016: Biomaterials
Tohru Momozane, Masayoshi Inoue, Yasushi Shintani, Soichiro Funaki, Tomohiro Kawamura, Masato Minami, Yukitoshi Shirakawa, Toru Kuratani, Yoshiki Sawa, Meinoshin Okumura
A case of locally advanced thymic carcinoma that was successfully resected with the great vessels after chemoradiation therapy is reported. A 57-year-old man with Masaoka stage III thymic carcinoma received two cycles of cisplatin/docetaxel and 60 Gy irradiation. The response was stable disease with 19% size reduction, and a radical resection with the ascending aorta and superior vena cava with the patient under circulatory arrest with the use of cardiopulmonary bypass was performed. The postoperative course was uneventful, and the patient has been free of disease for 28 months...
August 2016: Annals of Thoracic Surgery
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