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Xin Ye, Ke Wang, Yajie Zou, Dominique Lord
This paper develops a semi-nonparametric Poisson regression model to analyze motor vehicle crash frequency data collected from rural multilane highway segments in California, US. Motor vehicle crash frequency on rural highway is a topic of interest in the area of transportation safety due to higher driving speeds and the resultant severity level. Unlike the traditional Negative Binomial (NB) model, the semi-nonparametric Poisson regression model can accommodate an unobserved heterogeneity following a highly flexible semi-nonparametric (SNP) distribution...
2018: PloS One
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
Background: Randomized esophageal cancer (EC) trials have utilized two- or three-dimensional conformal radiotherapy (3DCRT). Advanced radiotherapy (RT) techniques [(ARTs): intensity-modulated radiotherapy (IMRT) and proton beam therapy (PBT)] may have benefits, but are relatively unproven. This is the first study to date evaluating utilization of ARTs versus 3DCRT in the trimodality setting in the United States. Methods: The National Cancer Data Base (NCDB) was queried (2004-2013) for newly-diagnosed cT1b-T4bN0/N+M0 EC receiving neoadjuvant CRT followed by esophagectomy...
April 2018: Journal of Gastrointestinal Oncology
Yuxin Liang, Mingshan Zhao, Zhenlin Wu, Geert Morthier
A grating-assisted trimodal interferometer biosensor is proposed and numerically analyzed. A long period grating coupler, for adjusting the power between the fundamental mode and the second higher order mode, is investigated, and is shown to act as a conventional directional coupler for adjusting the power between the two arms. The trimodal interferometer can achieve maximal fringe visibility when the powers of the two modes are adjusted to the same value by the grating coupler, which means that a better limit of detection can be expected...
May 10, 2018: Sensors
Judit Kalincsák, Péter Gőcze, József Bódis, Krisztina Kovács, Ágnes Stefanovits, Noémi Bohonyi, Sándor Péntek, Szilárd Papp
INTRODUCTION AND AIM: The aim of our study was to evaluate the prognostic factors and treatment options of a very rare and highly aggressive type of uterine neoplasms, the malignant mixed Müllerian tumor, known as carcinosarcoma. METHOD: Between 2009 and 2017, 29 patients were treated with malignant mixed Müllerian tumor. At stage I, surgery and postoperative radiotherapy were performed. At stages II-IV, trimodal treatment (surgery, chemotherapy and radiotherapy) was administered...
May 2018: Orvosi Hetilap
Jiecheng Cui, Ning Gao, Xianpeng Yin, Wanlin Zhang, Yun Liang, Li Tian, Kang Zhou, Shiqiang Wang, Guangtao Li
Creating hierarchical porosity in MOFs and controlling their size and morphology have emerged as efficient means for achieving significant improvement of MOF properties, and are crucial for facilitating the practical implementation of their various applications. Although important advances in this respect have been made, the realization of a hierarchical pore structure in a single crystalline MOF particle with controlled size and shape is still a challenge, and highly desirable. In this work, based on droplet-based microfluidics in conjunction with evaporative crystallization, an efficient approach to large-scale synthesis of uniform single-crystalline HKUST-1 particles with a hierarchical pore structure is presented...
May 4, 2018: Nanoscale
Elena Elimova, Xuemei Wang, Wei Qiao, Kazuki Sudo, Roopma Wadhwa, Hironori Shiozaki, Yusuke Shimodaira, Venkatram Planjery, Nikolaos Charalampakis, Jeffrey H Lee, Brian R Weston, Manoop S Bhutani, Ritsuko Komaki, David C Rice, Stephen G Swisher, Mariela A Blum, Jane E Rogers, Heath D Skinner, Dipen M Maru, Wayne L Hofstetter, Jaffer A Ajani
OBJECTIVE: The goal of surveillance after therapy of localized esophageal cancer (LEC) is to identify actionable relapses amenable to salvage; however, the current surveillance algorithms are not optimized. We report on a large cohort of LEC patients with actionable locoregional relapses (LRRs). METHODS: Between 2000 and 2013, 127 (denominator = 752) patients with actionable LRR were identified. Histologic/cytologic confirmation was the gold standard. All surveillance tools (imaging, endoscopy, fine needle aspiration) were assessed...
April 27, 2018: Oncology
Michael G Brandel, Robert C Rennert, Christian Lopez Ramos, David R Santiago-Dieppa, Jeffrey A Steinberg, Reith R Sarkar, Arvin R Wali, J Scott Pannell, James D Murphy, Alexander A Khalessi
BACKGROUND: Safety-net hospitals (SNHs) provide disproportionate care for underserved patients. Prior studies have identified poor outcomes, increased costs, and reduced access to certain complex, elective surgeries at SNHs. However, it is unknown whether similar patterns exist for the management of glioblastoma (GBM). We sought to determine if patients treated at HBHs receive equitable care for GBM, and if safety-net burden status impacts post-treatment survival. METHODS: The National Cancer Database was queried for GBM patients diagnosed between 2010 and 2015...
April 24, 2018: Journal of Neuro-oncology
Aaron M Allen, Tzippy Shochat, Dov Flex, Mordechai R Kramer, Alona Zer, Nir Peled, Elizabeta Dudnik, Eyal Fenig, Milton Saute
BACKGROUND: Trimodality therapy (chemoradiation followed by surgery) provides a benefit in progression-free survival but not overall survival. We sought to determine if a high dose of radiation could be delivered safely and provide a clinical benefit. METHODS: Consecutive patients with stage IIIA or IIIB non-small-cell lung cancer (NSCLC) treated with concurrent chemoradiotherapy followed by surgery were reviewed with IRB approval. RESULTS: A total of 48 patients were treated from November 2007 to May 2014...
April 20, 2018: Oncology
H A H Mohamed, M A Salem, M S Elnaggar, A Gabr, A M Abdelrheem
PURPOSE: A prospective phase II study carried out to evaluate hypofractionated radiotherapy with concurrent gemcitabine for bladder preservation in the elderly patient with bladder cancer. PATIENTS AND METHODS: Thirty-one patients were enrolled, age ≥65years, diagnosed with transitional cell carcinoma of the urinary bladder, after a maximum safe transurethral resection of a bladder tumour. They received 52.5Gy in 20 fractions using 3D conformal radiotherapy with concurrent 100mg/m2 gemcitabine weekly as a radiosensitizer...
April 17, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Stanislaw Szczerbinski, Jakub Ratajczak, Piotr Lach, Jakub Rzeszuto, Przemyslaw Paciorek, Joanna Karlowska-Pik, Bartosz Ziemkiewicz, Malgorzata Jasiewicz, Aldona Kubica
BACKGROUND: Although recent studies indicate temporal variations in the incidence of out-of-hospital cardiac arrest (OHCA), the Polish experience in this research is scarce to date. Epidemiology of OHCA and circadian is evaluated herein, weekly and seasonal variations of OHCA frequency among the adult population of the Opole district, Poland. METHODS: The retrospective analysis of 815 OHCA cases with presumed cardiac etiology was made based on dispatch cards from the Emergency Medical Center in Opole registered during a 2 year period (2006-2007)...
April 3, 2018: Cardiology Journal
Jacqueline R Kelly, Henry S Park, Yi An, Wendell G Yarbrough, Joseph N Contessa, Roy Decker, Saral Mehra, Benjamin L Judson, Barbara Burtness, Zain Husain
OBJECTIVES: Currently, human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV-A OPC) is managed with either primary surgery or definitive chemoradiotherapy (CRT), despite the lack of supporting randomized prospective data. We therefore assessed the outcomes of each treatment strategy using the National Cancer Database (NCDB). METHODS: The NCDB was used to identify patients diagnosed with cT1 N2a-2b or cT2 N1-2b HPV-A OPC from 2010 to 2013 who underwent treatment with primary surgery or CRT...
April 2018: Oral Oncology
Lucas Goense, Peter S N van Rossum, Mian Xi, Dipen M Maru, Brett W Carter, Gert J Meijer, Linus Ho, Richard van Hillegersberg, Wayne L Hofstetter, Steven H Lin
PURPOSE: To develop a nomogram that estimates 1-year recurrence-free survival (RFS) after trimodality therapy for esophageal adenocarcinoma and to assess the overall survival (OS) benefit of esophagectomy after chemoradiotherapy (CRT) on the basis of 1-year recurrence risk. METHODS: In total, 568 consecutive patients with potentially resectable esophageal adenocarcinoma who underwent CRT were included for analysis, including 373 patients who underwent esophagectomy after CRT (trimodality therapy), and 195 who did not undergo surgery (bimodality therapy)...
March 22, 2018: Annals of Surgical Oncology
Melissa A L Vyfhuis, Whitney M Burrows, Neha Bhooshan, Mohan Suntharalingam, James M Donahue, Josephine Feliciano, Shahed Badiyan, Elizabeth M Nichols, Martin J Edelman, Shamus R Carr, Joseph Friedberg, Gavin Henry, Shelby Stewart, Ashutosh Sachdeva, Edward M Pickering, Charles B Simone, Steven J Feigenberg, Pranshu Mohindra
PURPOSE: To determine, in a retrospective analysis of a large cohort of stage III non-small cell lung cancer patients treated with curative intent at our institution, whether having a pathologic complete response (pCR) influenced overall survival (OS) or freedom from recurrence (FFR) in patients who underwent definitive (≥60 Gy) neoadjuvant doses of chemoradiation (CRT). METHODS AND MATERIALS: At our institution, 355 patients with locally advanced non-small cell lung cancer were treated with curative intent with definitive CRT (January 2000-December 2013), of whom 111 underwent mediastinal reassessment for possible surgical resection...
February 13, 2018: International Journal of Radiation Oncology, Biology, Physics
Marsha Reyngold, Joyce Niland, Anna Ter Veer, Tanios Bekaii-Saab, Lily Lai, Joshua E Meyer, Steven J Nurkin, Deborah Schrag, John M Skibber, Al B Benson, Martin R Weiser, Christopher H Crane, Karyn A Goodman
Purpose: Intensity modulated radiation therapy (IMRT) has been rapidly incorporated into clinical practice because of its technological advantages over 3-dimensional conformal radiation therapy (CRT). We characterized trends in IMRT utilization in trimodality treatment of locally advanced rectal cancer at National Comprehensive Cancer Network cancer centers between 2005 and 2011. Methods and materials: Using the prospective National Comprehensive Cancer Network Colorectal Cancer Database, we determined treatment patterns for 976 patients with stage II-III rectal cancer who received pelvic radiation therapy at contributing centers between 2005 and 2011...
January 2018: Advances in Radiation Oncology
DanRong Hu, LiJuan Chen, Ying Qu, JinRong Peng, BingYang Chu, Kun Shi, Ying Hao, Lin Zhong, MengYao Wang, ZhiYong Qian
The combination of chemotherapy with photodynamic therapy (PDT) has attracted broad attention as it can overcome limitations of conventional chemo-treatment by using different modes of action. However, the efficacy of PDT to treat solid tumors is severely affected by hypoxia in tumors. Methods : In this study, we developed oxygen-generating theranostic nanoparticles (CDM NPs) by hierarchically assembling doxorubicin (DOX), chlorin e6 (Ce6) and colloidal manganese dioxide (MnO2 ) with poly (ε-caprolactone-co-lactide)-b-poly (ethylene glycol)-b-poly (ε-caprolactone-co-lactide) for treating breast cancer...
2018: Theranostics
Benjamin Benzon, Stephanie A Glavaris, Brian W Simons, Robert M Hughes, Kamyar Ghabili, Patrick Mullane, Rebecca Miller, Katriana Nugent, Brian Shinder, Jeffrey Tosoian, Ephraim J Fuchs, Phuoc T Tran, Paula J Hurley, Milena Vuica-Ross, Edward M Schaeffer, Charles G Drake, Ashley E Ross
BACKGROUND: Prostate cancer remains the second leading cause of cancer related death in men. Immune check point blocking antibodies have revolutionized treatment of multiple solid tumors, but results in prostate cancer remain marginal. Previous reports have suggested that local therapies, in particular cryoablation might increase tumor immunogenicity. In this work, we examine potential synergism between tumor cryoabalation and check point blocking antibodies. METHODS: FVB/NJ mice were injected subcutaneously into each flank with either 1 × 106 or 0...
April 2018: Prostate Cancer and Prostatic Diseases
Arianna Barbetta, Meier Hsu, Kay See Tan, Dessislava Stefanova, Koby Herman, Prasad S Adusumilli, Manjit S Bains, Matthew J Bott, James M Isbell, Yelena Y Janjigian, Geoffrey Y Ku, Bernard J Park, Abraham J Wu, David R Jones, Daniela Molena
OBJECTIVE: Definitive chemoradiotherapy (CRT) remains the most commonly used treatment for locally advanced esophageal squamous cell carcinoma (SCC), because of perceptions that esophagectomy offers an unclear survival advantage. We compare recurrence, overall survival (OS), and disease-free survival (DFS) in patients treated with definitive CRT or neoadjuvant CRT followed by surgery (trimodality). METHODS: This was a retrospective cohort study of patients with stage II and III SCC of the middle and distal esophagus in patients who completed CRT...
June 2018: Journal of Thoracic and Cardiovascular Surgery
Liuqi Peng, Xuan Mei, Jun He, Jiekun Xu, Weiku Zhang, Ruizheng Liang, Min Wei, David G Evans, Xue Duan
2D nanomaterials have attracted considerable research interest in drug delivery systems, owing to their intriguing quantum size and surface effect. Herein, Gd3+ -doped monolayered-double-hydroxide (MLDH) nanosheets are prepared via a facile bottom-up synthesis method, with a precisely controlled composition and uniform morphology. MLDH nanosheets as drug carrier are demonstrated in coloading of doxorubicin and indocyanine green (DOX&ICG), with an ultrahigh drug loading content (LC) of 797.36% and an encapsulation efficiency (EE) of 99...
April 2018: Advanced Materials
O S Eng, R A Nelson, I Konstantinidis, J Chao, L Erhunmwunsee, D J Raz, J Y Kim
Trimodality therapy with neoadjuvant chemoradiation followed by surgery has emerged as the standard of care for the treatment of locally advanced esophageal cancer. Yet, there is considerable variation in survival within this population. We sought to analyze factors associated with survival after trimodality therapy in esophageal adenocarcinoma. We identified 4,679 patients from the National Cancer Database (NCDB) of the American College of Surgeons who received chemotherapy and radiation prior to surgery for esophageal adenocarcinoma from 2006 to 2013...
March 8, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Penny Fang, Wen Jiang, Rajayogesh Davuluri, Cai Xu, Sunil Krishnan, Radhe Mohan, Albert C Koong, Charles C Hsu, Steven H Lin
BACKGROUND AND PURPOSE: Neoadjuvant chemoradiation (nCRT) can reduce tumor infiltrating lymphocytes. We examined absolute lymphocyte count (ALC) nadir during nCRT for esophageal cancer (EC) and pathologic complete response (pCR). MATERIALS AND METHODS: Patients with stage I-IVA EC (n = 313) treated 2007-2013 with nCRT followed by surgery were analyzed. ALC was obtained before, during/weekly, and one month after CRT. pCR was defined as no viable tumor cells at surgery...
March 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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