keyword
MENU ▼
Read by QxMD icon Read
search

Trimodal

keyword
https://www.readbyqxmd.com/read/28742692/oncologic-outcome-and-morbidity-in-the-elderly-rectal-cancer-patients-after-preoperative-chemoradiotherapy-and-total-mesorectal-excision-a-multi-institutional-and-case-matched-control-study
#1
Soo-Y Sung, Hong S Jang, Sung H Kim, Jae U Jeong, Songmi Jeong, Jin H Song, Mi J Chung, Hyeon M Cho, Hyung J Kim, Jun-Gi Kim, In K Lee, Jong H Lee
OBJECTIVE: To determine the toxicity and oncologic outcome of neoadjuvant chemoradiotherapy (CRT) followed by curative total mesorectal excision (TME) in the elderly (≥70 yrs) and younger (<70 yrs) rectal cancer patients. BACKGROUND: Sufficient data for elderly rectal cancer patients who received definitive trimodality have not been accumulated yet. PATIENTS AND METHODS: A total of 1232 rectal cancer patients who received neoadjuvant CRT and TME were enrolled in this study...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28737290/integration-of-ir-808-sensitized-upconversion-nanostructure-and-mos2-nanosheet-for-808-nm-nir-light-triggered-phototherapy-and-bioimaging
#2
Jiating Xu, Arif Gulzar, Yuhui Liu, Huiting Bi, Shili Gai, Bin Liu, Dan Yang, Fei He, Piaoping Yang
Near infrared (NIR) light triggered phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) affords superior outcome in cancer treatment. However, the reactive oxygen species (ROS) generated by NIR-excited upconversion nanostructure is limited by the feeble upconverted light which cannot activate PDT agents efficiently. Here, an IR-808 dye sensitized upconversion nanoparticle (UCNP) with a chlorin e6 (Ce6)-functionalized silica layer is developed for PDT agent. The two booster effectors (dye-sensitization and core-shell enhancement) synergistically amplify the upconversion efficiency, therefore achieving superbright visible emission under low 808 nm light excitation...
July 24, 2017: Small
https://www.readbyqxmd.com/read/28728163/nuclear-expression-of-gli-1-is-predictive-of-pathologic-complete-response-to-chemoradiation-in-trimodality-treated-oesophageal-cancer-patients
#3
Roopma Wadhwa, Xuemei Wang, Veerabhadran Baladandayuthapani, Bin Liu, Hironori Shiozaki, Yusuke Shimodaira, Quan Lin, Elena Elimova, Wayne L Hofstetter, Stephen G Swisher, David C Rice, Dipen M Maru, Neda Kalhor, Manoop S Bhutani, Brian Weston, Jeffrey H Lee, Heath D Skinner, Ailing W Scott, Dilsa Mizrak Kaya, Kazuto Harada, Donald Berry, Shumei Song, Jaffer A Ajani
BACKGROUND: Predictive biomarkers or signature(s) for oesophageal cancer (OC) patients undergoing preoperative therapy could help administration of effective therapy, avoidance of ineffective ones, and establishment new strategies. Since the hedgehog pathway is often upregulated in OC, we examined its transcriptional factor, Gli-1, which confers therapy resistance, we wanted to assess Gli-1 as a predictive biomarker for chemoradiation response and validate it. METHODS: Untreated OC tissues from patients who underwent chemoradiation and surgery were assessed for nuclear Gli-1 by immunohistochemistry and labelling indices (LIs) were correlated with pathologic complete response (pathCR) or <pathCR (resistance) and validated in a unique cohort...
July 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28700898/sub-100nm-long-tumor-retention-sn-38-loaded-photonic-micelles-for-tri-modal-cancer-therapy
#4
Xixiao Yang, Xiangdong Xue, Yan Luo, Tzu-Yin Lin, Hongyong Zhang, Diana Lac, Kai Xiao, Yixuan He, Bei Jia, Kit S Lam, Yuanpei Li
The tumor penetration and accumulation of nanoparticle-based drug delivery systems are highly dependent on the particle size. Nanomedicines in the sub-100nm range have been suggested by previous studies to have superior antitumor efficacy on various solid tumors. SN-38 is a very important and highly potent drug for several cancers including colon cancer. However, due to the ultra-flat aromatic structure of SN-38, it is typically very difficult to produce sub-100nm, SN-38-encapsulated nanoparticles without modification of the chemical structure...
July 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28685276/post-trimodality-expression-levels-of-metadherin-mtdh-as-a-prognostic-biomarker-for-esophageal-adenocarcinoma-patients
#5
Dilsa Mizrak Kaya, Xiaochuan Dong, Graciela M Nogueras-González, Yan Xu, Jeannelyn S Estrella, Kazuto Harada, Anthony Lopez, Fatemeh G Amlashi, Wayne L Hofstetter, Dipen M Maru, Quynh-Nhu Nguyen, Jeffrey H Lee, Brian Weston, Manoop S Bhutani, Jeremy J Erasmus, Irene Thomas, Jane E Rogers, Shumei Song, Jaffer A Ajani
Resectable esophageal adenocarcinoma (EAC) patients often receive chemoradiation followed by surgery. However, most patients experience recurrences. Overexpression of MTDH, an oncoprotein with multiple functions, has been found to be associated with poor prognosis in breast cancer, glioblastoma, melanoma and various gastrointestinal malignancies, but not in EAC. We sought to establish its role in resistant EAC (post-treatment residual EAC). MTDH was assessed by immunohistochemistry in resected EAC, and results were correlated with clinical outcomes...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28675905/do-we-need-to-add-postoperative-radiotherapy-in-patients-undergoing-trimodality-therapy-for-esophageal-squamous-cell-carcinoma-with-positive-lymph-nodes-disease
#6
Pei-Ming Huang, Feng-Ming Hsu, Chia-Chi Lin, Chin-Hung Hsu, Jason Chia-Hsien Cheng, Jang-Ming Lee
BACKGROUND: The role of adjuvant radiotherapy for positive lymph nodes (LN) in patients with esophageal cancer who received neoadjuvant concurrent chemoradiotherapy (CCRT) is not well established. This study is aimed at determining the impact of positive LN and the survival benefit of postoperative radiotherapy (PORT) after CCRT plus surgery on esophageal cancer patients. METHODS: Seventy patients with positive LN after neoadjuvant CCRT followed by esophagectomy were enrolled in the study...
July 4, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28670408/epidemiology-of-musculoskeletal-tuberculosis-in-an-area-with-high-disease-prevalence
#7
Michael F G Held, Sven Hoppe, Maritz Laubscher, Stewart Mears, Stewart Dix-Peek, Heather J Zar, Robert N Dunn
STUDY DESIGN: Retrospective observational study. PURPOSE: The aim of this study was to assess the distribution of age and site of infection in patients with musculoskeletal tuberculosis (TB) and determine the number of TB/human immunodeficiency virus (HIV) coinfections as well as the incidence of multidrugresistant (MDR) TB. OVERVIEW OF LITERATURE: Of all TB cases, 1%-3% show skeletal system involvement and 30% are HIV coinfected. Although the reported distribution of skeletal TB is majorly in the spine, followed by the hip, knee, and foot/ankle, the epidemiology of extrapulmonary TB and especially musculoskeletal TB remains largely unknown, particularly in areas with a high prevalence of the disease...
June 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28629896/randomized-phase-ii-study-of-preoperative-chemoradiotherapy-panitumumab-followed-by-consolidation-chemotherapy-in-potentially-operable-locally-advanced-stage-iiia-n2-non-small-cell-lung-cancer-nrg-oncology-rtog-0839
#8
Martin J Edelman, Chen Hu, Quynh-Thu Le, Jessica S Donington, Warren D D'Souza, Adam P Dicker, Billy W Loo, Elizabeth M Gore, Gregory M M Videtic, Nathaniel R Evans, Joseph W Leach, Maximilian Diehn, Steven J Feigenberg, Yuhchyau Chen, Rebecca Paulus, Jeffrey D Bradley
INTRODUCTION: Multimodality therapy has curative potential in locally advanced non-small cell lung cancer (LASCLC). Mediastinal nodal sterilization (MNS) after induction chemoradiotherapy (CRT) can serve as an intermediate marker for efficacy. NRG Oncology RTOG 0229 demonstrated the feasibility and efficacy of combining full dose radiation (61.2Gy) with chemotherapy followed by resection and chemotherapy. Based upon that experience and evidence that epidermal growth factor receptor (EGFR) antibodies are radiosensitizing, we explored adding panitumumab to CRT followed by resection and consolidation chemotherapy in LANSCLC with a primary endpoint of MNS...
June 16, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28628910/the-efficacy-of-trimodal-chemoradiotherapy-with-cisplatin-as-a-bladder-preserving-strategy-for-the-treatment-of-muscle-invasive-bladder-cancer
#9
Kazuhiro Nagao, Takahiko Hara, Jun Nishijima, Kosuke Shimizu, Nakanori Fujii, Keita Kobayashi, Yoshihisa Kawai, Ryo Inoue, Yoshiaki Yamamoto, Hiroaki Matsumoto, Hideyasu Matsuyama
INTRODUCTION: Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with those obtained by ORC. PATIENTS AND METHODS: We retrospectively analyzed the data of 50 patients with MIBC treated by trimodal chemoradiotherapy with cisplatin (CDDP-radiation [CDDP-R])...
June 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28624466/resectable-clinical-n2-non-small-cell-lung-cancer-what-is-the-optimal-treatment-strategy-an-update-by-the-british-thoracic-society-lung-cancer-specialist-advisory-group
#10
Matthew Evison, Amelia Clive, Lianne Castle, Helen Powell, Rachel Thomas, Robert Buttery, Vidan Masani, Susan Harden, Doug West, Ian Woolhouse
Patients and clinicians are faced with uncertainty as to the optimal treatment strategy for potentially resectable NSCLC in which there is clinical evidence of involvement of the ipsilateral mediastinum. Randomized controlled trials and meta-analyses have failed to demonstrate superiority of one bimodality strategy over another (chemotherapy plus surgery versus chemotherapy plus radiotherapy). One trial of trimodality treatment with chemotherapy, radiotherapy, and surgery demonstrated an improvement in progression-free, but not overall, survival versus chemotherapy and radiotherapy...
June 15, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28621623/patterns-of-care-and-outcomes-in-gliosarcoma-an-analysis-of-the-national-cancer-database
#11
Jonathan Frandsen, Andrew Orton, Randy Jensen, Howard Colman, Adam L Cohen, Jonathan Tward, Dennis C Shrieve, Gita Suneja
OBJECTIVE The authors compared presenting characteristics and survival for patients with gliosarcoma (GS) and glioblastoma (GBM). Additionally, they performed a survival analysis for patients who underwent GS treatments with the hypothesis that trimodality therapy (surgery followed by radiation and chemotherapy) would be superior to nontrimodality therapy (surgery alone or surgery followed by chemotherapy or radiation). METHODS Adults diagnosed with GS and GBM between the years 2004 and 2013 were queried from the National Cancer Database...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28616318/is-tumor-location-an-independent-prognostic-factor-in-locally-advanced-non-small-cell-lung-cancer-treated-with-trimodality-therapy
#12
EDITORIAL
Kazuhiko Shien, Shinichi Toyooka, Junichi Soh, Hiromasa Yamamoto, Shinichiro Miyoshi
No abstract text is available yet for this article.
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28608916/value-and-application-of-trimodality-therapy-or-definitive-concurrent-chemoradiotherapy-in-thoracic-esophageal-squamous-cell-carcinoma
#13
Wei-Cheng Lin, Yi-Fang Ding, Han-Lin Hsu, Jer-Hwa Chang, Kevin Sheng-Po Yuan, Alexander T H Wu, Jyh-Ming Chow, Chia-Lun Chang, Shee-Uan Chen, Szu-Yuan Wu
BACKGROUND: Few large, prospective, randomized studies have investigated the value and optimal application of neoadjuvant chemoradiotherapy followed by surgery (trimodality therapy) or definitive concurrent chemoradiotherapy (CCRT) for patients with thoracic esophageal squamous cell carcinoma (TESCC). METHODS: The authors analyzed data from patients with TESCC in the Taiwan Cancer Registry database. To compare their outcomes, patients with TESCC were enrolled and categorized into the following groups according to treatment modality: group 1, those who underwent surgery alone; group 2, those who received trimodality therapy; and group 3, those who received definitive CCRT...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28607886/managing-rhinophyma-by-trimodal-therapy-novel-approach
#14
K V Vishwas, Belliappa Pemmanda Raju, Umashankar Nagaraju
Rhinophyma is characterized by nodular thickening of the Nasal skin, sebaceous gland hyperplasia, dilated pores, and in its late stage, fibrosis. In severe cases, it results in loss of normal facial contours, significant disfigurement, and social isolation. Treatment options for severe rhinophyma include cryosurgery, partial-thickness decortications with subsequent secondary reepithelialisation, laser ablation, full thickness resection with graft or flap reconstruction, excision by electrocautery or radio frequency...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28580813/induction-chemotherapy-vs-post-operative-adjuvant-therapy-for-malignant-pleural-mesothelioma
#15
Giuseppe Marulli, Eleonora Faccioli, Alice Bellini, Marco Mammana, Federico Rea
Malignant pleural mesothelioma (MPM) is an aggressive neoplasia. Multidisciplinary treatments, including the association of induction and/or adjuvant therapeutic regimens with surgery, have been reported to give encouraging results. Current therapeutic options are not well standardized yet, especially regarding the best association between surgery and medical treatments. The present review aims to assess safety, efficacy and outcomes of different therapies for MPM. Areas covered: This article focuses on the multimodality treatment of mesothelioma...
August 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28577955/surgery-versus-chemotherapy-and-radiotherapy-for-early-and-locally-advanced-small-cell-lung-cancer-a-propensity-matched-analysis-of-survival
#16
E Wakeam, S A Acuna, N B Leighl, M E Giuliani, S R G Finlayson, T K Varghese, G E Darling
BACKGROUND: The role of surgery in small cell lung cancer (SCLC) is controversial. Survival outcomes for resection of stage I-IIIA SCLC compared to chemotherapy-based non-surgical treatment (NST) were examined using propensity matching. METHODS: 29,994 clinical stage I-IIIA SCLC patients, including 2,619 undergoing surgery, were identified in the National Cancer Database. Stage-specific propensity scores for receipt of surgery were created. Resected patients were matched 1:1 to those undergoing NST...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28575243/predictive-value-of-nodal-maximum-standardized-uptake-value-of-pretreatment-18f-fluorodeoxyglucose-positron-emission-tomography-imaging-in-patients-with-esophageal-cancer
#17
W-K Yap, Y-C Chang, C-K Tseng, C-H Hsieh, Y-K Chao, P-J Su, M-M Hou, C-K Yang, P-C Pai, C-R Lin, C-E Hsieh, Y-Y Wu, T-M Hung
We retrospectively reviewed 102 patients with esophageal cancer (97.1% squamous cell carcinoma, 96.1% stage III) received FDG-PET staging and were treated by chemoradiotherapy with or without resection to assess whether the pretreatment [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) maximum standardized uptake value (SUVmax) of the primary tumor and metastatic lymph nodes can predict the prognosis of patients with esophageal cancer. Receiver operating characteristic analysis was performed to find the cutoff values for primary tumor SUVmax and nodal SUVmax...
August 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28571883/reply-from-authors-re-girish-s-kulkarni-zachary-klaassen-trimodal-therapy-is-inferior-to-radical-cystectomy-for-muscle-invasive-bladder-cancer-using-population-level-data-is-there-evidence-in-the-lack-of-details-eur-urol-in-press-http-doi-org-10-1016-j-eururo
#18
EDITORIAL
https://www.readbyqxmd.com/read/28561906/outcomes-and-patterns-of-failure-for-sinonasal-undifferentiated-carcinoma-snuc-the-mayo-clinic-experience
#19
Mauricio E Gamez, Devyani Lal, Michele Y Halyard, William W Wong, Carlos Vargas, Daniel Ma, Stephen J Ko, Robert L Foote, Samir H Patel
BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a rare aggressive disease arising in the nasal cavity and paranasal sinuses with poor prognosis and unclear optimal management. METHODS: Forty patients were analyzed. Nasal cavity was the most common primary site. Most patients presented with T4 disease, received trimodality therapy, and were treated with intensity-modulated radiotherapy (IMRT). RESULTS: Median follow-up was 6.9 years...
May 31, 2017: Head & Neck
https://www.readbyqxmd.com/read/28558146/cyanine-based-nanoprobes-for-cancer-theranostics
#20
REVIEW
Pravin Bhattarai, Zhifei Dai
Cyanine dyes are greatly accredited in the development of non-invasive therapy that can "see" and "treat" tumor cells via imaging, photothermal and photodynamic treatment. However, these dyes suffer from poor pharmacokinetics inducing severe toxicity to normal cells, insufficient accumulation in tumor regions and rapid photobleaching when delivered in free forms. Nanoparticles engineered to encapsulate these compounds and delivering them into tumor regions have increased rapidly, however, so far, these nanoparticles (NPs) have not proved to be so effective to circumvent existing challenges...
May 30, 2017: Advanced Healthcare Materials
keyword
keyword
116502
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"