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https://www.readbyqxmd.com/read/28339761/combined-modality-therapy-in-stage-iiia-non-small-cell-lung-cancer-clarity-or-confusion-despite-the-highest-level-of-evidence
#1
Branislav Jeremic, Francesc Casas, Pavol Dubinsky, Antonio Gomez-Caamano, Nikola Cihoric, Gregory Videtic, Miroslav Latinovic
Recent years have witnessed a number of clinical trials in Stage IIIA non-small cell lung cancer (NSCLC) comparing (A) induction chemotherapy (CHT) with induction CHT and radiotherapy (RT), each followed by surgery; (B) either induction CHT or induction RT-CHT, each followed by surgery, with definitive RT-CHT (no surgery). Due to the heterogeneity of patient, tumor and treatment characteristics across these trials, various meta-analyses (MAs) have been performed to define the optimal treatment approach in this setting for this clinical presentation...
February 24, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28329246/lymphovascular-invasion-and-extracapsular-invasion-are-risk-factors-for-distant-recurrence-after-preoperative-chemoradiotherapy-and-oesophagectomy-in-patients-with-oesophageal-squamous-cell-carcinoma
#2
Po-Kuei Hsu, Ling-I Chien, Lei-Chi Wang, Teh-Ying Chou
OBJECTIVES: Patients with oesophageal squamous cell carcinoma have a high risk of disease recurrence even after trimodality treatments, which include preoperative chemoradiotherapy and oesophagectomy. We aimed to identify the histological factors that are associated with loco-regional and distant recurrence. METHODS: A retrospective review of a prospectively established database identified patients who received preoperative chemoradiotherapy and oesophagectomy for squamous cell carcinoma...
February 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28327075/magnetic-nanobubbles-with-potential-for-targeted-drug-delivery-and-trimodal-imaging-in-breast-cancer-an-in-vitro-study
#3
Weixiang Song, Yindeng Luo, Yajing Zhao, Xinjie Liu, Jiannong Zhao, Jie Luo, Qunxia Zhang, Haitao Ran, Zhigang Wang, Dajing Guo
AIM: The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. MATERIALS & METHODS: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIO-HER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging...
March 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322515/high-dose-radiation-with-chemotherapy-followed-by-salvage-esophagectomy-among-patients-with-locally-advanced-esophageal-squamous-cell-carcinoma
#4
Chawalit Lertbutsayanukul, Chadin Tharavej, Naruemon Klaikeaw, Anussara Prayongrat, Chutinan Lowanitchai, Virote Sriuranpong
BACKGROUND: Locoregional failure is a major problem associated with chemoradiation treatment for squamous cell esophageal carcinoma. The aim of this study was to assess the feasibility, efficacy, and toxicity of preoperative radiation (dose > 50 Gy) with platinum-based chemotherapy followed by esophagectomy in locally advanced squamous cell carcinoma. METHODS: Data of patients with cT2-cT4 or node positive squamous cell carcinoma of the esophagus who received trimodality treatment between February 2006 and June 2015 were reviewed...
March 21, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28295213/using-the-national-cancer-data-base-for-quality-evaluation-to-assess-adherence-to-treatment-guidelines-for-nonmetastatic-inflammatory-breast-cancer
#5
Heather Y Lin, Isabelle Bedrosian, Gildy V Babiera, Simona F Shaitelman, Henry M Kuerer, Wendy A Woodward, Naoto T Ueno, Yu Shen
BACKGROUND: Guidelines for the treatment of nonmetastatic inflammatory breast cancer (IBC) using trimodality therapy (TT) (chemotherapy, surgery, and radiotherapy) have remained largely unchanged since 2000. However, many patients with nonmetastatic IBC do not receive TT. It is unknown how patient-level (PL) and facility-level (FL) factors contribute to TT use. METHODS: Using the National Cancer Data Base, patients with nonmetastatic IBC who underwent locoregional treatment from 2003 through 2011 were identified...
March 13, 2017: Cancer
https://www.readbyqxmd.com/read/28279468/radiation-therapy-for-locally-advanced-esophageal-cancer
#6
REVIEW
Stephen G Chun, Heath D Skinner, Bruce D Minsky
The treatment of locally advanced esophageal cancer is controversial. For patients who are candidates for surgical resection, multiple prospective clinical trials have demonstrated the advantages of neoadjuvant chemoradiation. For patients who are medically inoperable, definitive chemoradiation is an alternative approach with survival rates comparable to trimodality therapy. Although trials of dose escalation are ongoing, the standard radiation dose remains 50.4 Gy. Modern radiotherapy techniques such as image-guided radiation therapy with motion management and intensity-modulated radiation therapy are strongly encouraged with a planning objective to maximize conformity to the intended target volume while reducing dose delivered to uninvolved normal tissues...
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28228042/haemoglobin-f-a2-and-s-levels-in-subjects-with-or-without-sickle-cell-trait-in-south-eastern-gabon
#7
Landry-Erik Mombo, Gaël Mabioko-Mbembo, Roland-Fabrice Kassa-Kassa, Emmanuel Ontsitsagui, Statiana Mboui-Ondo, Leatitia Nzé-Kamsi, Dieudonné Nkoghé, Jacques Elion
BACKGROUND: Infant mortality due to sickle cell disease in sub-Saharan Africa is high, necessitating a better understanding of the modulating factors of the disease in this region. METHODS: We assessed the hereditary persistence of foetal haemoglobin and α-thalassemia. We diagnosed 787 subjects, with or without sickle cell trait, by capillary electrophoresis in the Medical Diagnostic Laboratory of the CIRMF (Franceville, Gabon). RESULTS: Heterocellular and pancellular forms of hereditary persistence of foetal haemoglobin occurred at low rates of 10...
February 23, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28214031/the-impact-of-histological-variants-of-urothelial-carcinoma-on-clinical-outcomes-following-trimodality-bladder-sparing-chemoradiation
#8
EDITORIAL
Anne E Kiltie, Lisa Browning
No abstract text is available yet for this article.
February 14, 2017: European Urology
https://www.readbyqxmd.com/read/28198057/c18-cooh-silica-preparation-characterisation-and-its-application-in-purification-of-quaternary-ammonium-alkaloids-from-coptis-chinensis
#9
Qing Wang, Yao Long, Lin Yao, Mao Ye, Li Xu
INTRODUCTION: Traditional methods for isolating and purifying quaternary ammonium alkaloids from Coptis chinensis do not discriminate the target alkaloids from co-extractives. Mixed-mode analytical chromatography has the potential to improve the separation of analytes in more complex extracts and, when used in a solid-phase extraction mode, improve the purity of isolated compounds. OBJECTIVE: To examine the high-performance liquid chromatographic separation capabilities of a mixed-mode, silica-based adsorbent and its application to the purification of quaternary ammonium alkaloids from Coptis chinensis based on solid-phase extraction...
February 15, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28170224/sub-10-nm-sr2luf7-yb-er-sr2gdf7-srf2-up-conversion-nanocrystals-for-up-conversion-luminescence-magnetic-resonance-computed-tomography-trimodal-bioimaging
#10
Cailing Chen, Jianhua Liu, Ying Chen, Chunguang Li, Xiaomin Liu, He Huang, Chen Liang, Yue Lou, Zhan Shi, Shouhua Feng
Herein, sub-10 nm core-shell nanocrystals (NCs), which select Sr2LuF7:Yb/Er as core, Sr2GdF7 as middle shell, and SrF2 as an outermost shell, were synthesized by a seed-mediated growth process. The NCs possess good crystallinity, morphology, and up-conversion luminescent properties. After modification by polyethylenimine branched (PEI), in vitro cell up-conversion imaging with low autofluorescence was realized. Due to the presence of Gd(3+) ions, in vivo magnetic resonance (MR) imaging was also achieved with these designed NCs...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28145723/ultrasmall-silica-based-bismuth-gadolinium-nanoparticles-for-dual-magnetic-resonance-computed-tomography-image-guided-radiation-therapy
#11
Alexandre Detappe, Eloise Thomas, Mark W Tibbitt, Sijumon Kunjachan, Oksana Zavidij, Nishita Parnandi, Elizaveta Reznichenko, François Lux, Olivier Tillement, Ross Berbeco
Selective killing of cancer cells while minimizing damage to healthy tissues is the goal of clinical radiation therapy. This therapeutic ratio can be improved by image-guided radiation delivery and selective radiosensitization of cancer cells. Here, we have designed and tested a novel trimodal theranostic nanoparticle made of bismuth and gadolinium for on-site radiosensitization and image contrast enhancement to improve the efficacy and accuracy of radiation therapy. We demonstrate in vivo magnetic resonance (MR), computed tomography (CT) contrast enhancement, and tumor suppression with prolonged survival in a non-small cell lung carcinoma model during clinical radiation therapy...
March 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28138891/inflammatory-breast-cancer-in-the-netherlands-improved-survival-over-the-last-decades
#12
D J P van Uden, R Bretveld, S Siesling, J H W de Wilt, C F J M Blanken-Peeters
PURPOSE: Locally advanced breast cancer (LABC) includes inflammatory breast cancer (IBC) as well as non-inflammatory LABC (NI-LABC). The aim of this population-based study was to compare the tumour characteristics, treatment and relative survival of IBC and NI-LABC patients. METHODS: Patients with either IBC (cT4d) or NI-LABC (cT4a-c) were identified from the nationwide Netherlands Cancer Registry from the period 1989-2015. In each group, patients are divided into three time periods in order to perform a trend analysis: 1989-1997, 1998-2006, and 2007-2015...
April 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28129606/pet-mr-versus-pet-ct-in-the-initial-staging-of-head-and-neck-cancer-using-a-trimodality-pet-ct-mr-system
#13
Tetsuro Sekine, Felipe de Galiza Barbosa, Felix P Kuhn, Irene A Burger, Paul Stolzmann, Gerhard F Huber, Spyros S Kollias, Gustav K von Schulthess, Patrick Veit-Haibach, Martin W Huellner
PURPOSE: To compare the diagnostic accuracy of PET+MR with PET/CT in the initial staging of head and neck cancer. MATERIALS AND METHODS: Contrast-enhanced PET/CT+MR was performed in 27 patients with newly diagnosed head and neck cancer. PET/CT and PET+MR were evaluated separately, and the TNM stage and factors influencing treatment were assessed. RESULTS: The TNM staging by PET+MR was comparable to PET/CT (T: p=0.331, N: p=0.453, M: p=0.034)...
January 17, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28103913/prognostic-histological-factors-in-patients-with-esophageal-squamous-cell-carcinoma-after-preoperative-chemoradiation-followed-by-surgery
#14
Cheng-Che Tu, Po-Kuei Hsu, Ling-I Chien, Wan-Chen Liu, Chien-Sheng Huang, Chih-Cheng Hsieh, Han-Shui Hsu, Yu-Chung Wu
BACKGROUND: Pathological response is an important marker for tumor aggressiveness in patients with esophageal squamous cell carcinoma (ESCC) who receive preoperative chemoradiation followed by esophagectomy. We aim to evaluate the prognostic value of histological factors after trimodality treatments. METHODS: 91 patients who received preoperative chemoradiation followed by transthoracic esophagectomy between 2009 and 2014 were included. The pathological examination was reviewed...
January 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28081432/changes-in-age-patterns-of-suicide-in-australia-the-united-states-japan-and-hong-kong
#15
John Snowdon, Julie Phillips, Baoliang Zhong, Takashi Yamauchi, Helen F K Chiu, Yeates Conwell
The patterns of association between age and suicide rate vary by country, subpopulation and gender, and over time. To shed light on factors associated with these differences, we analysed suicide data from four populations, two 'Western' (Australia, the United States [US]) and two Asian (Japan and Hong Kong). We computed suicide rates in five-year age-groups (between 10 and 14 years and 85+ years) for men and women separately, and present graphical representations of the age patterns during selected five-year periods...
March 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28079430/multimodal-prehabilitation-improves-functional-capacity-before-and-after-colorectal-surgery-for-cancer-a-five-year-research-experience
#16
Enrico Maria Minnella, Guillaume Bousquet-Dion, Rashami Awasthi, Celena Scheede-Bergdahl, Francesco Carli
BACKGROUND: Multimodal prehabilitation is a preoperative conditioning intervention in form of exercise, nutritional assessment, whey protein supplementation, and anxiety-coping technique. Despite recent evidence suggesting that prehabilitation could improve functional capacity in patients undergoing colorectal surgery for cancer, all studies were characterized by a relatively small sample size. The aim of this study was to confirm what was previously found in three small population trials...
February 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28056876/a-case-report-of-primary-unilateral-adrenal-nk-t-cell-lymphoma-good-clinical-outcome-with-trimodality-treatment
#17
Liu Hu, Weimin Xu, Mingwei Wang, Pan Wang, Guang Han, Chi Lin
BACKGROUND: Primary natural killer (NK)/T cell lymphoma of adrenal glands is an extremely rare tumor with aggressive clinical behavior. There have only been a few cases reported worldwide and the highest reported survival was 90 days. We report the first case of primary unilateral adrenal NK/T cell lymphoma in China with good outcome. CASE PRESENTATION: This is a 28-year-old man who presented with abdominal pain and was found to have a large mass on the left adrenal and the top of the renal region...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28056116/comparison-of-survival-outcomes-among-human-papillomavirus-negative-ct1-2-n1-2b-patients-with-oropharyngeal-squamous-cell-cancer-treated-with-upfront-surgery-vs-definitive-chemoradiation-therapy-an-observational-study
#18
Jacqueline R Kelly, Henry S Park, Yi An, Joseph N Contessa, Wendell G Yarbrough, Barbara A Burtness, Roy Decker, Zain Husain
Importance: Human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) has shown resistance to conventional concurrent chemoradiation (CRT) therapy and carries a relatively poor prognosis in comparison with HPV-positive disease, with decreased locoregional control and overall survival (OS). In the present analysis, we examine whether upfront surgical resection improves overall survival in a large national sample. Objective: To compare survival outcomes among patients with newly diagnosed cT1-2 N1-2b HPV-negative OPSCC when treated with primary surgical resection vs CRT...
January 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28040351/clinical-outcomes-of-patients-with-histologic-variants-of-urothelial-cancer-treated-with-trimodality-bladder-sparing-therapy
#19
Ross E Krasnow, Michael Drumm, Hannah J Roberts, Andrzej Niemierko, Chin-Lee Wu, Shulin Wu, Jing Zhang, Niall M Heney, Matthew F Wszolek, Michael L Blute, Adam S Feldman, Richard J Lee, Anthony L Zietman, William U Shipley, Jason A Efstathiou
BACKGROUND: Trimodality bladder-sparing therapy (TMT) is an acceptable treatment for selected patients with muscle-invasive urothelial cancer. Outcomes of TMT in histologic variants remains largely unknown. OBJECTIVE: To compare outcomes of pure urothelial carcinoma (PUC) to variant urothelial carcinoma (VUC) after TMT. DESIGN, SETTING, AND PARTICIPANTS: Retrospective study of patients treated with TMT at a single cancer center from 1993 until 2013...
December 28, 2016: European Urology
https://www.readbyqxmd.com/read/28035321/patterns-of-bladder-preservation-therapy%C3%A2-utilization-for-muscle-invasive-bladder-cancer
#20
Tracy L Rose, Allison M Deal, Sylvain Ladoire, Gilles Créhange, Matthew D Galsky, Jonathan E Rosenberg, Joaquim Bellmunt, Akhila Wimalasingham, Yu-Ning Wong, Lauren C Harshman, Simon Chowdhury, Guenter Niegisch, Michalis Liontos, Evan Y Yu, Sumanta K Pal, Ronald C Chen, Andrew Z Wang, Matthew E Nielsen, Angela B Smith, Matthew I Milowsky
Background: Trimodality bladder preservation therapy (BPT) in muscle invasive bladder cancer (MIBC) includes a maximal transurethral resection followed by concurrent chemoradiotherapy as an alternative to radical cystectomy (RC) in appropriately selected patients, or as a treatment option in non-cystectomy candidates. Several chemotherapy regimens can be used in BPT, but little is known about current practice patterns. Objective: To describe utilization patterns of BPT and associated survival outcomes in MIBC...
October 27, 2016: Bladder Cancer
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