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https://www.readbyqxmd.com/read/27903668/malignant-pleural-mesothelioma-an-update-on-investigation-diagnosis-and-treatment
#1
Anna C Bibby, Selina Tsim, Nikolaos Kanellakis, Hannah Ball, Denis C Talbot, Kevin G Blyth, Nick A Maskell, Ioannis Psallidas
Malignant pleural mesothelioma is an aggressive malignancy of the pleural surface, predominantly caused by prior asbestos exposure. There is a global epidemic of malignant pleural mesothelioma underway, and incidence rates are predicted to peak in the next few years.This article summarises the epidemiology and pathogenesis of malignant pleural mesothelioma, before describing some key factors in the patient experience and outlining common symptoms. Diagnostic approaches are reviewed, including imaging techniques and the role of various biomarkers...
December 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27899955/comparison-between-standard-and-reduced-volume-radiotherapy-in-bladder-preservation-trimodality-protocol-for-muscle-invasive-bladder-cancer-patients
#2
Waleed Arafat, Azza Darwish, George E Naoum, Wael Sameh, Gamal El Husseiny, Fathy Abd-El-Gawad, Mostafa Samir
AIM: Our aim is to compare the toxicity, pelvic nodal relapse, and overall survival of whole bladder irradiation only to the standard technique of whole pelvis irradiation followed by bladder boost in patients with muscle-invasive bladder carcinoma undergoing bladder preservation protocol. MATERIAL AND METHOD: A total of 60 patients with transitional cell carcinoma, stage T2-3, N0, M0 bladder cancer were subjected to maximal transurethral resection bladder tumour (TURB)...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27895808/mendelian-inheritance-of-trimodal-cpg-methylation-sites-suggests-distal-cis-acting-genetic-effects
#3
Shaza B Zaghlool, Mashael Al-Shafai, Wadha A Al Muftah, Pankaj Kumar, Christian Gieger, Melanie Waldenberger, Mario Falchi, Karsten Suhre
BACKGROUND: Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers of inherited information. At the population level, the methylation state of such "heritable" CpG sites is expected to follow a trimodal distribution, and their mode of inheritance should be Mendelian. METHODS: Using the Illumina Infinium 450 K DNA methylation array, we determined DNA CpG-methylation in blood cells from a family cohort 123 individuals of Arab ethnicity, including 18 elementary father-mother-child trios, we asked whether Mendelian inheritance of CpG methylation is observed, and most importantly, whether it is independent of any genetic signals...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27867706/simultaneous-in-vivo-imaging-of-diffuse-optical-reflectance-optoacoustic-pressure-and-ultrasonic-scattering
#4
Pavel Subochev, Anna Orlova, Irina Mikhailova, Natalia Shilyagina, Ilya Turchin
We present reflection-mode bioimaging system providing complementary optical, photoacsoutic and acoustic measurements by acoustic detector after each laser pulse. While the photons absorbed within the sample provide optoacoustic (OA) signals, the photons absorbed by the external electrode of a detector provide the measurable diffuse reflectance (DR) from the sample and the probing ultrasonic (US) pulse. To demonstrate the in vivo capabilities of the system we present the results of complementary DR/OA/US imaging of a mouse tumor, head of a newborn rat, and the back of a newborn rat with 3...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27862953/dual-stimuli-responsive-nanotheranostics-for-multimodal-imaging-guided-trimodal-synergistic-therapy
#5
Shan Fang, Jing Lin, Chunxiao Li, Peng Huang, Wenxiu Hou, Chunlei Zhang, Jingjing Liu, Sisi Huang, Yongxiang Luo, Wenpei Fan, Daxiang Cui, Yunsheng Xu, Zhiming Li
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single imaging modality, and higher therapeutic efficiency than any single one or their simple "mechanical" combination. Herein, we report a dual-stimuli responsive nanotheranostic based on a hierarchical nanoplatform, composed of mesoporous silica-coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), and 5-fluorouracil (5-FU), for in vivo multimodal imaging guided synergistic therapy. The 5-FU loaded ICG-conjugated silica-coated gold nanorods (GNR@SiO2-5-FU-ICG) was able to response specifically to the two stimuli of pH change and near-infrared (NIR) light irradiation...
November 15, 2016: Small
https://www.readbyqxmd.com/read/27861763/assessment-of-the-treatment-approach-and-survival-outcomes-in-a-modern-cohort-of-patients-with-atypical-teratoid-rhabdoid-tumors-using-the-national-cancer-database
#6
Benjamin W Fischer-Valuck, Ishita Chen, Amar J Srivastava, John M Floberg, Yuan James Rao, Allison A King, Eric T Shinohara, Stephanie M Perkins
BACKGROUND: Atypical teratoid rhabdoid tumors (ATRTs) are rare brain tumors that occur primarily in children under the age of 3 years. This report evaluates the treatment approach and survival outcomes in a large cohort of patients treated in the United States. METHODS: Using the National Cancer Database, the analysis included all ATRT patients aged 0 to 18 years who were diagnosed between 2004 and 2012 and had complete treatment data. RESULTS: Three hundred sixty-one ATRT patients were evaluated...
November 2, 2016: Cancer
https://www.readbyqxmd.com/read/27816896/simultaneous-seeg-meg-eeg-recordings-overcome-the-seeg-limited-spatial-sampling
#7
Martine Gavaret, Anne-Sophie Dubarry, Romain Carron, Fabrice Bartolomei, Agnès Trébuchon, Christian-George Bénar
During presurgical evaluation of pharmacoresistant partial epilepsies, stereoelectroencephalography (SEEG) records interictal and ictal activities directly but is inherently limited in spatial sampling. In contrast, scalp-EEG and MEG are less sensitive but provide a global view on brain activity. Therefore, recording simultaneously these three modalities should provide a better understanding of the underlying brain sources by taking advantage of the different sensitivities of the three recording techniques...
December 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27804284/learning-styles-academic-achievement-and-mental-health-problems-among-medical-students-in-thailand
#8
Salilthip Paiboonsithiwong, Natchaya Kunanitthaworn, Natchaphon Songtrijuck, Nahathai Wongpakaran, Tinakon Wongpakaran
PURPOSE: This study aimed to investigate the prevalence of various learning styles among medical students and their correlations with academic achievement and mental health problems in these students. METHODS: This study was conducted among 140 first-year medical students of Chiang Mai University, Thailand in 2014. The participants completed the visual-aural-read/write-kinesthetic (VARK) questionnaire, the results of which can be categorized into 4 modes, corresponding to how many of the 4 types are preferred by a respondent...
2016: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/27804027/prognostic-factors-for-locoregional-recurrence-in-patients-with-thoracic-esophageal-squamous-cell-carcinoma-treated-with-radical-two-field-lymph-node-dissection-results-from-long-term-follow-up
#9
ShiLiang Liu, Simone Anfossi, Bo Qiu, YuZhen Zheng, MuYan Cai, Jia Fu, Hong Yang, Qing Liu, ZhaoLin Chen, JianHua Fu, MengZhong Liu, Jared K Burks, Steven H Lin, James Reuben, Hui Liu
OBJECTIVE: To aim of this study was to determine the clinical and biological prognostic factors for locoregional recurrence (LRR) in patients with thoracic esophageal squamous cell carcinoma (ESCC) undergoing radical two-field lymph node dissection (2FLD). METHODS: A total of 462 patients diagnosed with thoracic ESCC underwent radical esophagectomy between March 2001 and May 2010 at Sun Yat-Sen University Cancer Center. Clinical characteristics, CD44 expression, and tumor-infiltrating lymphocyte (TIL) levels were evaluated in 198 patients who underwent R0 dissection with long-term follow-up...
November 1, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27786592/diagnosing-and-treating-pancoast-tumors
#10
Konstantinos Zarogoulidis, Konstantinos Porpodis, Kelly Domvri, Ellada Eleftheriadou, Despoina Ioannidou, Paul Zarogoulidis
According to the American College of Chest Physician definition, a Pancoast tumor is a tumor which invades any of the structures of the apex of the chest including the first thoracic ribs or periosteum, the lower nerve roots of the bronchial plexus, the sympathetic chain and stellate gaglion near the apex of the chest or the subclavian vessels. Pancoast tumors account for less than 3-5 % of lung tumors. Areas covered: We searched the libraries scopus and pub med and found 124 related manuscripts. From those we chose 18 to include in our short commentary based on the most up-date information included...
December 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27770974/trimodality-approach-to-stage-iiia-n2-nsclc-as-good-as-it-gets
#11
EDITORIAL
Andrea Bezjak, Marc de Perrot
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27740758/self-organized-3d-porous-graphene-dual-doped-with-biomass-sponsored-nitrogen-and-sulfur-for-oxygen-reduction-and-evolution
#12
Ibrahim Saana Amiinu, Jian Zhang, Zongkui Kou, Xiaobo Liu, Owusu Kwadwo Asare, Huang Zhou, Kun Cheng, Haining Zhang, Liqiang Mai, Mu Pan, Shichun Mu
3D graphene-based materials offer immense potentials to overcome the challenges related to the functionality, performance, cost, and stability of fuel cell electrocatalysts. Herein, a nitrogen (N) and sulfur (S) dual-doped 3D porous graphene catalyst is synthesized via a single-row pyrolysis using biomass as solitary source for both N and S, and a structure directing agent. The thermochemical reaction of biomass functional groups with graphene oxide facilitates in situ generation of reactive N and S species, stimulating the graphene layers to reorganize into a trimodal 3D porous assembly...
October 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27737963/long-term-single-institute-experience-with-trimodal-bladder-preserving-therapy-with-proton-beam-therapy-for-muscle-invasive-bladder-cancer
#13
Ei-Ichiro Takaoka, Jun Miyazaki, Hitoshi Ishikawa, Koji Kawai, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Reiko Kanuma, Daichi Takizawa, Toshiyuki Okumura, Hideyuki Sakurai, Hiroyuki Nishiyama
OBJECTIVE: We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving therapy for muscle-invasive bladder cancer at our institution. METHODS: From 1990 to 2015, 70 patients with cT2-3N0M0 muscle-invasive bladder cancer underwent trimodal bladder-preserving therapy consisting of maximal transurethral resection of the bladder tumor, small pelvis photon irradiation, intra-arterial chemotherapy and proton beam therapy...
October 13, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27727064/quality-of-life-in-long-term-survivors-of-muscle-invasive-bladder-cancer
#14
Kimberley S Mak, Angela B Smith, Alec Eidelman, Rebecca Clayman, Andrzej Niemierko, Jed-Sian Cheng, Jonathan Matthews, Michael R Drumm, Matthew E Nielsen, Adam S Feldman, Richard J Lee, Anthony L Zietman, Ronald C Chen, William U Shipley, Matthew I Milowsky, Jason A Efstathiou
PURPOSE: Health-related quality of life (QOL) has not been well-studied in survivors of muscle-invasive bladder cancer (MIBC). The present study compared long-term QOL in MIBC patients treated with radical cystectomy (RC) versus bladder-sparing trimodality therapy (TMT). METHODS AND MATERIALS: This cross-sectional bi-institutional study identified 226 patients with nonmetastatic cT2-cT4 MIBC, diagnosed in 1990 to 2011, who were eligible for RC and were disease free for ≥2 years...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27720827/timing-of-surgery-after-neoadjuvant-chemoradiation-in-locally-advanced-non-small-cell-lung-cancer
#15
Sarah J Gao, Christopher D Corso, Elyn H Wang, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Roy H Decker, Anthony W Kim
INTRODUCTION: A subset of patients with potentially resectable clinical stage IIIA NSCLC are managed with trimodality therapy. However, little data exist to guide the timing of surgery after neoadjuvant therapy. This study examined whether the time interval between neoadjuvant chemoradiation (NCRT) and surgical resection affects overall survival. METHODS: Patients with clinical stage IIIA disease (T1-3 N2) NSCLC who underwent NCRT were identified in the National Cancer Data Base (NCDB) between 2004 and 2012 and categorized on the basis of the interval between chemoradiation and surgery (0 to ≤3, >3 to ≤6, >6 to ≤9, and >9 to ≤12 weeks)...
October 5, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27709789/comprehensive-study-of-the-macropore-and-mesopore-size-distributions-in-polymer-monoliths-using-complementary-physical-characterization-techniques-and-liquid-chromatography
#16
Sam Wouters, Tom Hauffman, Marjo C Mittelmeijer-Hazeleger, Gadi Rothenberg, Gert Desmet, Gino V Baron, Sebastiaan Eeltink
Poly(styrene-co-divinylbenzene) monolithic stationary phases with two different domain sizes were synthesized by a thermally initiated free-radical copolymerization in capillary columns. The morphology was investigated at the meso- and macroscopic level using complementary physical characterization techniques aiming at better understanding the effect of column structure on separation performance. Varying the porogenic solvent ratio yielded materials with a mode pore size of 200 nm and 1.5 μm, respectively...
December 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27687305/is-the-routine-use-of-trimodality-therapy-for-selected-patients-with-non-small-cell-lung-cancer-supported-by-long-term-clinical-outcomes
#17
C Dickhoff, K J Hartemink, J Kooij, P M van de Ven, M A Paul, E F Smit, M Dahele
No abstract text is available yet for this article.
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27676507/p1-21-novel-pet-parameters-as-predictors-of%C3%A2-pathologic-response-in-patients-with%C3%A2-stage-iiia-n2-nsclc-receiving-trimodality-therapy-track-early-stage-nsclc-stage-i-iii
#18
Andrea L Arnett, Ann T Packard, Yolanda I Garces, Kenneth W Merrell
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27675768/are-new-ypn-stages-predictive-of-survival-in-477-lung-cancer-patients-who-underwent-trimodality-therapy-for-initial-pn2-disease
#19
H Kim, Y C Ahn, H R Pyo, D Oh, J M Noh, M J Ahn, K Park, J Kim, J I Zo, Y M Shim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675737/trimodality-therapy-is-tolerable-and-feasible-in-patients-with-postprostatectomy-high-risk-pathologic-p-t2-3n0m0-prostate-cancer-results-of-a-phase-1-2-trial
#20
P Kumar, P Veldhuizen, M Thompson, X Shen, J Pinski
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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