keyword
MENU ▼
Read by QxMD icon Read
search

Trimodal

keyword
https://www.readbyqxmd.com/read/28522744/fdg-pet-response-after-induction-chemotherapy-can-predict-who-will-benefit-from-subsequent-esophagectomy-after-chemoradiotherapy-for-esophageal-adenocarcinoma
#1
Mian Xi, Zhongxing Liao, Wayne L Hofstetter, Ritsuko Komaki, Linus Ho, Steven H Lin
This study aimed to determine whether (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) response after induction chemotherapy before concurrent chemoradiotherapy can identify patients with esophageal adenocarcinoma who may benefit from subsequent esophagectomy. Methods: We identified and analyzed 220 patients with esophageal adenocarcinoma who had received induction chemotherapy before chemoradiotherapy, with or without surgery, with curative intent; all underwent FDG-PET scanning before and after induction chemotherapy...
May 18, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28516155/phase-i-clinical-trial-of-everolimus-combined-with-trimodality-therapy-in-patients-with-muscle-invasive-bladder-cancer
#2
Bassel G Bachir, Luis Souhami, Jose João Mansure, Fabio Cury, Marie Vanhuyse, Fadi Brimo, Armen G Aprikian, Simon Tanguay, Jeremy Sturgeon, Wassim Kassouf
Background: Local control following trimodality therapy (TMT) for muscle-invasive bladder cancer (MIBC) requires further optimization. Objective: Evaluating the biologic endpoint, feasibility, and toxicity of integrating everolimus to TMT in patients with MIBC. Methods: This was a phase I trial in patients with MIBC who were not surgical candidates or who refused cystectomy. Following maximal transurethral tumor resection, patients were treated by radiotherapy (50 Gy/20 fractions), gemcitabine (100 mg/m2/weekly) and escalating doses of everolimus (2...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28502409/field-evaluation-of-a-wearable-multimodal-soldier-navigation-system
#3
Iina Aaltonen, Jari Laarni
Challenging environments pose difficulties for terrain navigation, and therefore wearable and multimodal navigation systems have been proposed to overcome these difficulties. Few such navigation systems, however, have been evaluated in field conditions. We evaluated how a multimodal system can aid in navigating in a forest in the context of a military exercise. The system included a head-mounted display, headphones, and a tactile vibrating vest. Visual, auditory, and tactile modalities were tested and evaluated using unimodal, bimodal, and trimodal conditions...
September 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28489981/evolving-treatment-of-advanced-urothelial-cancer
#4
Srikala S Sridhar
Urothelial cancer of the bladder is a smoking-related cancer and the fifth most common cancer in the United States. At presentation, up to 25% of patients will have muscle-invasive disease and, despite cystectomy or bladder-sparing trimodality approaches, will develop metastatic disease. Cisplatin-based combination chemotherapy regimens remain the standard of care in first-line metastatic disease. Although response rates to these regimens are high, they are rarely durable, and median overall survival is only 12 to 15 months...
May 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28483329/trimodal-therapy-is-inferior-to-radical-cystectomy-for-muscle-invasive-bladder-cancer-using-population-level-data-is-there-evidence-in-the-lack-of-details
#5
EDITORIAL
Girish S Kulkarni, Zachary Klaassen
No abstract text is available yet for this article.
May 5, 2017: European Urology
https://www.readbyqxmd.com/read/28482086/induction-chemotherapy-extrapleural-pneumonectomy-and-adjuvant-radiotherapy-for-malignant-pleural-mesothelioma
#6
Monica Casiraghi, Patrick Maisonneuve, Daniela Brambilla, Piergiorgio Solli, Domenico Galetta, Francesco Petrella, Gaia Piperno, Filippo De Marinis, Lorenzo Spaggiari
OBJECTIVES: While the best approach to malignant pleural mesothelioma has yet to be demonstrated, surgery remains the mainstay of treatment. We analysed a group of candidates for trimodality treatment, aiming to identify prognostic factors guiding patient selection. METHODS: Between 2003 and 2015, 83 (31.6%) of the 283 patients with malignant pleural mesothelioma were considered for trimodality treatment to perform induction chemotherapy, extrapleural pneumonectomy and adjuvant radiotherapy...
May 8, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28476435/a-multi-institutional-analysis-of-trimodality-therapy-for-esophageal-cancer-in-elderly-patients
#7
Scott C Lester, Steven H Lin, Michael Chuong, Neha Bhooshan, Zhongxing Liao, Andrea L Arnett, Sarah E James, Jaden D Evans, Grant M Spears, Ritsuko Komaki, Michael G Haddock, Minesh P Mehta, Christopher L Hallemeier, Kenneth W Merrell
PURPOSE: The therapeutic gains of neoadjuvant chemoradiation therapy (nCRT) followed by esophagectomy may be offset by increased incidences of morbidity and mortality in elderly patients. This study aimed to determine the impact of age on the risks and benefits of trimodality therapy for esophageal cancer. METHODS AND MATERIALS: We evaluated 571 patients treated with trimodality therapy at 3 high-volume tertiary cancer centers in the United States from 2007 to 2013...
February 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28475728/a-retrospective-comparison-of-neoadjuvant-chemoradiotherapy-regimens-for-locally-advanced-esophageal-cancer
#8
N N Sanford, P J Catalano, P C Enzinger, B L King, R Bueno, N E Martin, T S Hong, J Y Wo, H J Mamon
Preoperative chemoradiotherapy (CRT) with carboplatin/paclitaxel has been shown to increase survival in patients with esophageal cancer, including gastroesophageal junction (GE) junction cancer, over surgery alone; however, there have been no studies comparing the different neoadjuvant CRT regimens. We retrospectively evaluated the long-term results of trimodality therapy for patients with locally advanced esophageal cancer treated on several chemotherapy regimens. Between 1999 and 2014, 215 patients with locally advanced esophageal cancer underwent neoadjuvant CRT followed by surgical resection...
July 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28475724/neoadjuvant-chemoradiotherapy-with-concurrent-cisplatin-5-fluorouracil-is-associated-with-increased-pathologic-complete-response-and-improved-survival-compared-to-carboplatin-paclitaxel-in-patients-with-locally-advanced-esophageal-cancer
#9
K R Haisley, K D Hart, N Nabavizadeh, K G Bensch, G M Vaccaro, C R Thomas, P H Schipper, J G Hunter, J P Dolan
Trimodal therapy consisting of neoadjuvant chemoradiation followed by esophagectomy has become the standard of care in North America for locally advanced esophageal cancer. While cisplatin/5-fluorouracil has been a common concurrent chemotherapy regimen since the 1980s, its utilization has declined in recent years as the Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) trial regimen of carboplatin/paclitaxel has become widely adopted. The efficacy of the CROSS regimen compared to alternate chemotherapy choices, however, has rarely been evaluated when each is used as a component of a trimodal treatment approach...
July 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28469299/systemic-therapy-in-bladder-cancer
#10
REVIEW
Ian G Pinto
Systemic chemotherapy is essential for the management of muscle-invasive bladder cancer (MIBC) and metastatic bladder cancer (BCa). Neoadjuvant chemotherapy is key to the management of MIBC with many cisplatin-based regimens. Adjuvant chemotherapy may be considered for selected patients who did not receive neoadjuvant therapy. Systemic chemotherapy with radiotherapy is a critical component of a trimodal bladder-preserving approach and is superior to radiotherapy alone. Cisplatin-based chemotherapy has been the mainstay for metastatic BCa...
April 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28469298/where-are-we-with-bladder-preservation-for-muscle-invasive-bladder-cancer-in-2017
#11
REVIEW
Woodson Wade Smelser, Marcus A Austenfeld, Jeffrey Maxwell Holzbeierlein, Eugene Kang Lee
INTRODUCTION: In 2017, neoadjuvant, cisplatin-based chemotherapy followed by radical cystectomy (RC) is considered the gold standard therapy for muscle-invasive bladder based on randomized controlled trials. Across all tumor stages, this approach has been associated with the highest rates of disease-specific survival. However, RC is one of the most challenging procedures performed by urologic surgeons and carries with it significant risks of complications, hospital readmission, and even a small risk of mortality, in addition to lifestyle changes that can have long-term effects on well-being...
April 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28465803/the-prevalence-and-expression-pattern-of-melanoma-associated-antigen-1-in-esophageal-squamous-cell-carcinoma-a-historical-cohort-study
#12
Kazem Anvari, Azar Fani Pakdel, Bahram Memar, Roya Parsamanesh, Seyyed Mojtaba Ejlalzadeh, Seyed Alireza Javadinia
INTRODUCTION: Melanoma-associated antigen 1 (MAGE1) expression in normal tissues is restricted to the testes, whilst being over-expressed in a number of human cancers. This feature of MAGE1 makes it a promising cancer biomarker. This study aimed to determine the expression of MAGE1 in esophageal squamous cell carcinoma (SCC) and its relationship with clinicopathological factors. METHODS: This is a cross-sectional study conducted on pretreatment endoscopic tissue specimens of 43 patients with non-metastatic esophageal SCC, admitted to Omid Hospital, Mashhad, Iran, between 2011 and 2013...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28464527/drug-pent-up-in-hollow-magnetic-prussian-blue-nanoparticles-for-nir-induced-chemo-photothermal-tumor-therapy-with-trimodal-imaging
#13
Jinghua Li, Fengshou Zhang, Zhigang Hu, Weidong Song, Guangda Li, Gaofeng Liang, Jun Zhou, Ke Li, Yang Cao, Zhong Luo, Kaiyong Cai
The study reports a biocompatible smart drug delivery system based on a doxorubicin (DOX) blending phase-change material of 1-pentadecanol loaded hollow magnetic Prussian blue nanoparticles, resulting in HMNP-PB@Pent@DOX. The system possesses concentration-dependent high thermogenesis (>50 °C) when applying a near-infrared (NIR) laser irradiation only for 5 min. Furthermore, the system realizes near "zero release" of drug and is efficiently triggered by NIR for drug delivery in an "on" and "off" manner, thus inducing cell apoptosis in vitro and in vivo...
May 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28443140/chemoradiotherapy-in-octogenarians-as-primary-treatment-for-muscle-invasive-bladder-cancer
#14
Victor A McPherson, George Rodrigues, Glenn Bauman, Eric Winquist, Joseph Chin, Jonathan Izawa, Kylea Potvin, Scott Ernst, Varagur Venkatesan, Tracy Sexton, Belal Ahmad, Nicholas Power
INTRODUCTION: While radical cystectomy is the gold standard for muscle-invasive bladder cancer (MIBC), in octogenarians cystectomy results in a higher perioperative mortality rate (6.8-11.1%) than in younger patients (2.2%). Trimodality therapy is a bladder-sparing regimen composed of transurethral resection of bladder tumour (TURBT) and chemoradiotherapy, with intent for salvage cystectomy, and has a 62.5-90% initial complete response rate. In this study, we evaluate TURBT and chemoradiotherapy without salvage cystectomy in medically inoperable octogenarian patients...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28434030/spatial-and-temporal-distributions-of-air-pollutants-and-size-distribution-of-aerosols-over-central-and-eastern-china
#15
Honglei Wang, Lijuan Shen, Bin Zhu, Hanqing Kang, Xuewei Hou, Qing Miao, Yang Yang, Shuangshuang Shi
The origins and spatial and temporal distributions of air pollutants (PM2.5, PM10, CO, SO2, NO2 and O3) during May to June of 2015 were investigated using data from 1490 monitoring sites in China. Aerosol number concentrations and meteorological data from Shijiazhuang, Nanjing, and Suzhou were combined with the MIX Asian emission data and the HYSPLIT model. Furthermore, the diurnal variation, size distribution, and main sources of air pollutants and aerosols were selectively characterized in the North China Plain (NCP) and the Yangtze River Delta (YRD)...
May 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28425040/schiff-base-complexes-of-copper-and-zinc-as-potential-anti-colitic-compounds
#16
Elaine M Conner, John Reglinski, W Ewen Smith, I Jack Zeitlin
The design, synthesis and activity of polymodal compounds for the treatment of inflammatory bowel disease are reported. The compounds, being based on a metal-Schiff base motif, are designed to degrade during intestinal transit to release the bioactive components in the gut. The compounds have been developed sequential with the biomodal compounds combining copper or zinc with a salicylaldehyde adduct. These compounds were tested in a formalin induced colonic inflammation model in BK:A mice. From these studies a trimodal compound based on a zinc Schiff base analogue of sulfasalazine was designed...
June 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28412065/comparative-effectiveness-of-trimodal-therapy-versus-radical-cystectomy-for-localized-muscle-invasive-urothelial-carcinoma-of-the-bladder
#17
Thomas Seisen, Maxine Sun, Stuart R Lipsitz, Firas Abdollah, Jeffrey J Leow, Mani Menon, Mark A Preston, Lauren C Harshman, Adam S Kibel, Paul L Nguyen, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
Given the lack of randomized evidence comparing trimodal therapy (TMT) to radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB), we performed an observational cohort study to examine the comparative effectiveness of these two definitive treatments. Within the National Cancer Data Base (2004-2011),we identified 1257 (9.8%) and 11 586 (90.2%) patients who received TMT and RC, respectively. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier analysis showed that median overall survival (OS) was similar between the TMT (40 mo, 95% confidence interval [CI] 34-46) and RC groups (43 mo 95% CI 41-45; p=0...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28410011/propensity-score-analysis-of-radical-cystectomy-versus-bladder-sparing-trimodal-therapy-in-the-setting-of-a-multidisciplinary-bladder-cancer-clinic
#18
Girish S Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J Bostrom, Cynthia Kuk, Kathy Li, Arnoud J Templeton, Srikala S Sridhar, Theodorus H van der Kwast, Peter Chung, Robert G Bristow, Michael Milosevic, Padraig Warde, Neil E Fleshner, Michael A S Jewett, Shaheena Bashir, Alexandre R Zlotta
Purpose Multidisciplinary management improves complex treatment decision making in cancer care, but its impact for bladder cancer (BC) has not been documented. Although radical cystectomy (RC) currently is viewed as the standard of care for muscle-invasive bladder cancer (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethral resection of bladder tumor, chemotherapy for radiation sensitization, and external beam radiotherapy has emerged as a valid treatment option. In the absence of randomized studies, this study compared the oncologic outcomes between patients treated with RC or TMT by using a propensity score matched-cohort analysis...
April 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28409916/surfactant-free-aqueous-synthesis-of-novel-ba2gdf7-yb-3-er-3-peg-upconversion-nanoparticles-for-in-vivo-trimodality-imaging
#19
Yang Feng, Hongda Chen, Lina Ma, Baiqi Shao, Shuang Zhao, Zhenxin Wang, Hongpeng You
In this work, we developed the surfactant-free aqueous synthesis of novel polyethylene glycol (PEG) coated Ba2GdF7:Yb(3+), Er(3+) upconversion nanoparticles (named as, Ba2GdF7:Yb(3+), Er(3+)@PEG UCNPs) for in vivo multimodality imaging including upconversion luminescence (UCL), X-ray computed tomography (CT), and T1-weighted magnetic resonance (MR). The as-prepared Ba2GdF7:Yb(3+), Er(3+)@PEG UCNPs not only present bright UCL and reasonably high CT/MR enhancements but also exhibit excellent colloidal stability, inappreciable cytotoxicity, and negligible organ toxicity...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28407473/trimodal-rescue-of-hind-limb-ischemia-with-growth-factors-cells-and-nanocarriers-fundamentals-to-clinical-trials
#20
Rajesh Lakshmanan, Gopi Ukani, Muhammad Tipu Rishi, Nilanjana Maulik
Peripheral artery disease is a severe medical condition commonly characterized by critical or acute limb ischemia. Gradual accumulation of thrombotic plaques in peripheral arteries of the lower limb may lead to intermittent claudication or ischemia in muscle tissue. Ischemic muscle tissue with lesions may become infected, resulting in a non-healing wound. Stable progression of the non-healing wound associated with severe ischemia might lead to functional deterioration of the limb, which, depending on the severity, can result in amputation...
April 13, 2017: Canadian Journal of Physiology and Pharmacology
keyword
keyword
116502
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"