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https://www.readbyqxmd.com/read/29236220/automatic-lung-segmentation-in-functional-spect-images-using-active-shape-models-trained-on-reference-lung-shapes-from-ct
#1
Grigorios-Aris Cheimariotis, Mariam Al-Mashat, Kostas Haris, Anthony H Aletras, Jonas Jögi, Marika Bajc, Nicolaos Maglaveras, Einar Heiberg
OBJECTIVE: Image segmentation is an essential step in quantifying the extent of reduced or absent lung function. The aim of this study is to develop and validate a new tool for automatic segmentation of lungs in ventilation and perfusion SPECT images and compare automatic and manual SPECT lung segmentations with reference computed tomography (CT) volumes. METHODS: A total of 77 subjects (69 patients with obstructive lung disease, and 8 subjects without apparent perfusion of ventilation loss) performed low-dose CT followed by ventilation/perfusion (V/P) SPECT examination in a hybrid gamma camera system...
December 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29223511/ultra-low-dose-quantitative-ct-myocardial-perfusion-imaging-with-sparse-view-dynamic-acquisition-and-image-reconstruction-a-feasibility-study
#2
Esmaeil Enjilela, Ting-Yim Lee, Jiang Hsieh, Gerald Wisenberg, Patrick Teefy, Andrew Yadegari, Rodrigo Bagur, Ali Islam, Kelley Branch, Aaron So
PURPOSE: We implemented and validated a compressed sensing (CS) based algorithm for reconstructing dynamic contrast-enhanced (DCE) CT images of the heart from sparsely sampled X-ray projections. METHODS: DCE CT imaging of the heart was performed on five normal and ischemic pigs after contrast injection. DCE images were reconstructed with filtered backprojection (FBP) and CS from all projections (984-view) and 1/3 of all projections (328-view), and with CS from 1/4 of all projections (246-view)...
November 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29222218/fat-embolism-a-rare-cause-of-perioperative-renal-transplant-dysfunction
#3
Jemima Scott, Neil Collin, Richard Baker, Rommel Ravanan
Fat embolism is a recognised complication of bony injury and orthopaedic surgery, commonly involving the long bones and pelvis. We report on the case of a 68-year-old renal transplant recipient who developed acute kidney injury following surgical stabilisation of metastatic carcinoma of the acetabulum and replacement of the proximal femur. A CT renal angiogram demonstrated a large fat embolus in the inferior vena cava (IVC) and left iliac veins below the level of IVC filter, with impaired renal perfusion. The risks of open or endovascular lipothrombectomy were felt to outweigh the potential benefits...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29220708/comparative-diagnostic-accuracy-of-dual-energy-ct-myocardial-perfusion-imaging-by-monochromatic-energy-versus-material-decomposition-methods
#4
Ibrahim Danad, Iksung Cho, Kimberly Elmore, Joshua Schulman-Marcus, Bríain Ó Hartaigh, Wijnand J Stuijfzand, Patricia Carrascosa, James K Min
PURPOSE: To compare the diagnostic value of monochromatic and material decomposition (MD) dual- energy computed tomography (DECT) imaging for the evaluation of ischemia. METHODS: Patients with suspected coronary artery disease underwent rest-stress DECT and SPECT perfusion imaging. DECT images were reconstructed between 40 and 140keV and through MD of iodine/muscle. RESULTS: MD and monochromatic imaging had a sensitivity, specificity, negative predictive, positive predictive value, and accuracy of 89%, 40%, 67%, 73% and 71%; and 91%, 67%, 67%, 91% and 86%, respectively (p=0...
November 11, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29218615/advanced-ct-for-diagnosis-of-seizure-related-stroke-mimics
#5
Friederike Austein, Monika Huhndorf, Johannes Meyne, Helmut Laufs, Olav Jansen, Thomas Lindner
BACKGROUND AND PURPOSE: It is assumed that up to 30 % of clinically diagnosed acute ischaemic strokes (AIS) are actually stroke mimics (SM). Our aim was to evaluate the usefulness of advanced CT including CT angiography (CTA) and CT perfusion (CTP) findings when distinguishing AIS from seizure-related SM. METHODS: Over a 22-month period data were gathered of patients who presented to our stroke centre with AIS-like symptoms and were examined immediately with an advanced CT, analysed and evaluated by two experienced neuroradiologists who preferred SM rather than AIS...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29218511/optical-monitoring-of-cerebral-microcirculation-in-neurointensive-care
#6
Peter Rejmstad, Neda Haj-Hosseini, Oscar Åneman, Karin Wårdell
Continuous optical monitoring of local cerebral microcirculation could benefit neurointensive care patients treated for subarachnoid hemorrhage (SAH). The aim of the study was to evaluate laser Doppler flowmetry (LDF) and diffuse reflectance spectroscopy (DRS) for long-term monitoring of brain microcirculation and oxygen saturation (SO2) in the neurointensive care unit (NICU). A fiber optic probe was designed for intraparenchymal use and connected to LDF and DRS for assessment of the local blood flow (perfusion and tissue reflectance (TLI)) and SO2 in the brain...
December 8, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29216309/coronary-to-pulmonary-artery-fistula-in-adults-evaluation-with-thallium-201-myocardial-perfusion-spect
#7
Seul Ki Lee, Jung Im Jung, Joo Hyun O, Hwan Wook Kim, Ho Joong Youn
OBJECTIVES: With the increasing use of multi-detector CT, the number of detected cases with coronary-to-pulmonary artery fistula (CPAF) has increased. Several previous studies reported severe cases of angina, but no appropriate tests to evaluate myocardial perfusion for patients with CPAF have been established. We evaluated the hemodynamic characteristics of CPAF using thallium-201 (Tl-201) single photon emission computed tomography (SPECT). MATERIALS AND METHODS: Tl-201 SPECT was performed in 17 patients with CPAF, but without evidence of coronary artery disease on coronary computed tomography angiography (CCTA) (age, 58...
2017: PloS One
https://www.readbyqxmd.com/read/29215416/cardiac-fibroma-an-uncommon-cause-of-a-fixed-defect-on-myocardial-perfusion-imaging
#8
Sarah Pittman, Pooja Sethi, Robert R Flavell, Miguel Hernandez Pampaloni
A 66-year-old woman was referred for evaluation of coronary artery disease. Myocardial perfusion imaging (MPI) was performed, and showed a medium-sized, severe fixed perfusion defect in the inferior and inferolateral wall from apex to midcavity. On review of prior imaging, it was noted that the patient had an incidental finding of an intramural cardiac mass on chest CT performed 8 years prior. Subsequent cardiac MRI showed findings consistent with a cardiac fibroma in the left ventricle, at the location of the perfusion defect on MPI...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29215412/serial-fdg-pet-ct-imaging-in-the-management-of-cardiac-sarcoidosis
#9
William Bremer, Nadera J Sweiss, Yang Lu
A 60-year-old woman with biopsy-proven cardiac sarcoidosis status post implantable cardioverter defibrillator placement presented with periodic dizziness and dyspnea on exertion. Myocardial perfusion scan demonstrated a moderate sized, fixed perfusion defect along the mid to proximal anteroseptal wall of the left ventricle, with better perfusion on stress images. FDG-PET/CT demonstrated corresponding focal FDG avidity of the mid to proximal anteroseptal wall, suggestive of active cardiac sarcoidosis. Because of severe side effects, mycophenolate mofetil was discontinued, and the patient received low-dose steroid therapy...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29208767/the-feasibility-of-low-concentration-contrast-and-low-tube-voltage-in-computed-tomography-perfusion-imaging-an-animal-study
#10
Yuning Pan, Aiqin Song, Shizhong Bu, Zhaoqian Chen, Qiuli Huang, Aijing Li
Aim: To investigate the feasibility of low-concentration contrast (270 mg/mL) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion imaging. Method: A total of 15 healthy New Zealand rabbits received two CT scans each. The first scan (control) was acquired at 100 kV and 100 mA with iopromide (370 mg/mL), while the second scan (experimental) was acquired at 80 kV and 100 mA with iodixanol (270 mg/mL) 24 hours after the first scan...
December 5, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29208237/imaging-the-human-placental-microcirculation-with-micro-focus-computed-tomography-optimisation-of-tissue-preparation-and-image-acquisition
#11
Rosalind Pratt, J Ciaran Hutchinson, Andrew Melbourne, Maria A Zuluaga, Alex Virasami, Tom Vercauteren, Sebastien Ourselin, Neil J Sebire, Owen J Arthurs, Anna L David
Micro-CT provides 3D volume imaging with spatial resolution at the micrometre scale. We investigated the optimal human placenta tissue preparation (contrast agent, perfusion pressure, perfusion location and perfusion vessel) and imaging (energy, target material, exposure time and frames) parameters. Microfil (Flow Tech, Carver, MA) produced better fill than Barium sulphate (84.1%(±11.5%)vs70.4%(±18.02%) p = 0.01). Perfusion via umbilical artery produced better fill than via chorionic vessels (83.8%(±17...
December 2017: Placenta
https://www.readbyqxmd.com/read/29205466/ischemic-core-thresholds-change-with-time-to-reperfusion-a-case-control-study
#12
Andrew Bivard, Tim Kleinig, Ferdinand Miteff, Kenneth Butcher, Longting Lin, Christopher Levi, Mark Parsons
INTRODUCTION: We aimed to identify if acute ischemic stroke patients with known complete reperfusion after thrombectomy had the same baseline CTP ischemic core threshold to predict infarction as thrombolysis patients with complete reperfusion. METHODS: Patients who underwent thrombectomy were matched by age, clinical severity, occlusion location, and baseline perfusion lesion volume to patients who were treated with intravenous alteplase alone from the International Stroke Perfusion Imaging Registry...
December 4, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29203534/author-response-evaluation-of-hyperacute-infarct-volume-using-aspects-and-brain-ct-perfusion-core-volume
#13
Christopher R Levi, Jelle Demeestere, Carlos Garcia-Esperon, Pablo García-Bermejo, Fouke Ombelet, Patrick McElduff, Andrew Bivard, Mark Parsons
No abstract text is available yet for this article.
December 5, 2017: Neurology
https://www.readbyqxmd.com/read/29203533/letter-re-evaluation-of-hyperacute-infarct-volume-using-aspects-and-brain-ct-perfusion-core-volume
#14
Kars C J Compagne, Adriaan C G M van Es, Aad van der Lugt, Diederik W J Dippel
No abstract text is available yet for this article.
December 5, 2017: Neurology
https://www.readbyqxmd.com/read/29203532/letter-re-evaluation-of-hyperacute-infarct-volume-using-aspects-and-brain-ct-perfusion-core-volume
#15
Biplab Das, Apara Kothiala, Anshu Mahajan, Gaurav Goel, Arun Garg
No abstract text is available yet for this article.
December 5, 2017: Neurology
https://www.readbyqxmd.com/read/29203289/time-and-dose-related-changes-in-lung-perfusion-after-definitive-radiotherapy-for-nsclc
#16
Katherina P Farr, Azza A Khalil, Ditte S Møller, Henrik Bluhme, Stine Kramer, Anni Morsing, Cai Grau
BACKGROUND AND PURPOSE: To examine radiation-induced changes in regional lung perfusion per dose level in 58 non-small-cell lung cancer (NSCLC) patients treated with intensity-modulated radiotherapy (IMRT). MATERIAL AND METHODS: NSCLC patients receiving chemo-radiotherapy (RT) of minimum 60 Gy were included prospectively in the study. Lung perfusion single-photon emission computed tomography (SPECT/CT) was performed before and serially after RT. Changes (relative to baseline, %) in regional lung perfusion were correlated with regional dose...
December 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29196345/mitoprotection-attenuates-myocardial-vascular-impairment-in-porcine-metabolic-syndrome
#17
Fang Yuan, Ahmad F Hedayat, Christopher M Ferguson, Amir Lerman, Lilach O Lerman, Alfonso Eirin
INTRODUCTION: The metabolic syndrome (MetS) leads to cardiac vascular injury, which may reflect in increased retention of endothelial progenitor cells (EPC). Coronary endothelial cell (EC) mitochondria partly regulate vascular function and structure. We hypothesized that chronic mitoprotection would preserve EC mitochondria and attenuate coronary vascular injury and dysfunction in swine MetS. METHODS: Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elamipretide (ELAM, 0...
December 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29191614/accuracy-of-a-cone-beam-ct-virtual-parenchymal-perfusion-algorithm-for-liver-cancer-targeting-during-intra-arterial-therapy
#18
Haytham Derbel, Hicham Kobeiter, Guillaume Pizaine, Fourat Ridouani, Alain Luciani, Alessandro Radaelli, William Van der Sterren, Mélanie Chiaradia, Vania Tacher
PURPOSE: To evaluate accuracy of virtual parenchymal perfusion (VPP) algorithm developed for targeting liver cancer during intra-arterial therapy (IAT) using cone-beam CT guidance. MATERIALS AND METHODS: VPP was retrospectively applied to 15 patients who underwent IAT for liver cancer. Virtual territory (VT) was estimated after positioning a virtual injection point on nonselective dual-phase (DP) cone-beam CT images acquired during hepatic arteriography at the same position chosen for selective treatment...
November 27, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29190675/in-patients-with-suspected-acute-stroke-ct-perfusion-based-cerebral-blood-flow-maps-cannot-substitute-for-dwi-in-measuring-the-ischemic-core
#19
William A Copen, Albert J Yoo, Natalia S Rost, Lívia T Morais, Pamela W Schaefer, R Gilberto González, Ona Wu
BACKGROUND: Neuroimaging may guide acute stroke treatment by measuring the volume of brain tissue in the irreversibly injured "ischemic core." The most widely accepted core volume measurement technique is diffusion-weighted MRI (DWI). However, some claim that measuring regional cerebral blood flow (CBF) with CT perfusion imaging (CTP), and labeling tissue below some threshold as the core, provides equivalent estimates. We tested whether any threshold allows reliable substitution of CBF for DWI...
2017: PloS One
https://www.readbyqxmd.com/read/29189398/quantification-of-the-effect-of-shuttling-on-computed-tomography-perfusion-parameters-by-investigation-of-aortic-inputs-on-different-table-positions-from-shuttle-mode-scans-of-lung-and-liver-tumors
#20
Payel Ghosh, Adam G Chandler, Brian P Hobbs, Jia Sun, John Rong, David Hong, Vivek Subbiah, Filip Janku, Aung Naing, Wen-Jen Hwu, Chaan S Ng
OBJECTIVES: The aim of this study was to quantify the effect of shuttling on computed tomography perfusion (CTp) parameters derived from shuttle-mode body CT images using aortic inputs from different table positions. METHODS: Axial shuttle-mode CT scans were acquired from 6 patients (10 phases, 2 nonoverlapping table positions 1.4 seconds apart) after contrast agent administration. Artifacts resulting from the shuttling motion were corrected with nonrigid registration before computing CTp maps from 4 aortic levels chosen from the most superior and inferior slices of each table position scan...
November 16, 2017: Journal of Computer Assisted Tomography
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