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https://www.readbyqxmd.com/read/29662787/steroid-associated-osteonecrosis-animal-model-in-rats
#1
Li-Zhen Zheng, Jia-Li Wang, Ling Kong, Le Huang, Li Tian, Qian-Qian Pang, Xin-Luan Wang, Ling Qin
Objective: Established preclinical disease models are essential for not only studying aetiology and/or pathophysiology of the relevant diseases but more importantly also for testing prevention and/or treatment concept(s). The present study proposed and established a detailed induction and assessment protocol for a unique and cost-effective preclinical steroid-associated osteonecrosis (SAON) in rats with pulsed injections of lipopolysaccharide (LPS) and methylprednisolone (MPS). Methods: Sixteen 24-week-old male Sprague-Dawley rats were used to induce SAON by one intravenous injection of LPS (0...
April 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661601/corrigendum-to-evaluation-of-texture-analysis-parameter-for-response-prediction-in-patients-with-hepatocellular-carcinoma-undergoing-drug-eluting-bead-transarterial-chemoembolization-deb-tace-using-biphasic-contrast-enhanced-ct-image-data-correlation-with-liver
#2
Christopher Kloth, Wolfgang Maximilian Thaiss, Rainer Kärgel, Rainer Grimmer, Jan Fritz, Sorin Dumitru Ioanoviciu, Dominik Ketelsen, Konstantin Nikolaou, Marius Horger
No abstract text is available yet for this article.
April 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29652229/a-useful-diagnostic-method-to-reduce-the-in-hospital-time-delay-for-mechanical-thrombectomy-volume-perfusion-computed-tomography-with-added-vessel-reconstruction
#3
Ho Jun Yi, Jae Hoon Sung, Dong Hoon Lee, Seung Ho Yang, Jae Taek Hong
OBJECTIVE Volume perfusion CT (VPCT) with added CT angiography (CTA)-like reconstruction from VPCT source data (VPCTA) can reveal multiple intracranial parameters. The authors examined the usefulness of VPCTA in terms of reducing the in-hospital time delay for mechanical thrombectomy. METHODS A total of 180 patients who underwent mechanical thrombectomy at the authors' institution between January 2014 and March 2017 were divided into 2 groups: a CTA-based thrombectomy decision group (group 1: CTA) and a VPCTA-based decision group (group 2: VPCTA)...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29651557/higher-admission-fasting-plasma-glucose-levels-are-associated-with-a-poorer-short-term-neurologic-outcome-in-acute-ischemic-stroke-patients-with-good-collateral-circulation
#4
Feng Wang, Beisi Jiang, Lasheta Kanesan, Yuwu Zhao, Bernard Yan
AIMS: In this retrospective study, we sought to delineate the collateral circulation status of acute ischemic stroke patients by CT perfusion and evaluate 90-day modified Rankin Scale (mRS) scores of patients with good or poor collaterals and its correlation with admission fasting plasma glucose (FPG). METHODS: We enrolled acute ischemic stroke patients who presented to our hospital 4.5 h within an onset of the first episode between January 2009 and December 2015...
April 12, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29649783/radiation-dose-reduction-in-perfusion-ct-imaging-of-the-brain-using-a-256-slice-ct-80-mas-versus-160-mas
#5
Isabelle Riederer, Claus Zimmer, Daniela Pfeiffer, Silke Wunderlich, Holger Poppert, Ernst J Rummeny, Armin Huber
PURPOSE: To examine CTP of the brain in real patient data after reducing tube current down to 80 mAs to decrease radiation dose. METHODS: CTP was acquired in 60 suspected stroke patients with 80 (n: 30) or 160 (n: 30) mAs. Data were analyzed retrospectively by two independent readers. SNR, perfusion maps and image quality were compared in hypoperfused and non-affected areas. RESULTS: SNR was significantly higher in CTP with 160 mAs compared to 80 mAs (p < 0...
April 5, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29643681/mismatch-in-brain-perfusion-and-metabolism-detected-with-99m-tc-hexamethyl-propylene-amine-oxime-single-photon-emission-computed-tomography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-moyamoya-disease
#6
Justo Serrano Vicente, Luis Fernández Prudencio, José Rafael Infante Torre, Juan Ignacio Rayo Madrid
We report a 47-year-old woman who developed an ischemic stroke with diplopia and dysarthria. Emergency computed tomography (CT) showed no pathological findings, and magnetic resonance (MR) showed mild ischemic-degenerative lesions. MR angiography and angiogram showed severe stenosis of both internal carotid and main intracranial arteries with plenty collateral vessels with "puff of smoke" suggesting a moyamoya disease (MMD). Brain perfusion single-photon emission CT showed global diminished perfusion in the brain lobes and a marked relative hyperperfusion in the cerebellum...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29643522/-three-dimensional-architecture-of-intraosseous-vascular-anatomy-of-the-hamate-a-micro-computed-tomography-study
#7
D Y Wang, X Li, Z C Shen, P L Gu, Y R Pei, G Zeng, H J Leng, W G Zhang
OBJECTIVE: To obtain three-dimensional intraosseous artery of the hamate and to provide the vascular anatomy basis of hamate fracture fixation. METHODS: PbO (lead monoxide, Sinopharm Chemical Reagent Beijing Co. Ltd) was ground into particles less than 40 μm and suspended in turpentine oil (Chemical Reagent Beijing Co. Ltd) at ratios of 1 g : 1.5 mL, 1 g : 1 mL and 1 g : 0.5 mL. Three specimens were investigated. Brachial arteries were cannulated and perfused with lead-based contrast agent...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29629796/advances-in-pancreatic-ct-imaging
#8
Renata R Almeida, Grace C Lo, Manuel Patino, Bernardo Bizzo, Rodrigo Canellas, Dushyant V Sahani
OBJECTIVE: The purpose of this article is to discuss the advances in CT acquisition and image postprocessing as they apply to imaging the pancreas and to conceptualize the role of radiogenomics and machine learning in pancreatic imaging. CONCLUSION: CT is the preferred imaging modality for assessment of pancreatic diseases. Recent advances in CT (dual-energy CT, CT perfusion, CT volumetry, and radiogenomics) and emerging computational algorithms (machine learning) have the potential to further increase the value of CT in pancreatic imaging...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29627375/longer-diabetes-duration-reduces-myocardial-blood-flow-in-remote-myocardium-assessed-by-dynamic-myocardial-ct-perfusion
#9
Nobuo Tomizawa, Yusuke Fujino, Masaru Kamitani, Shengpu Chou, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Sunao Nakamura
AIMS: To investigate the relationship of type 2 diabetes duration and myocardial blood flow (MBF) assessed by myocardial CT perfusion. MATERIALS AND METHODS: We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the deconvolution technique and the Voronoi method. The relationships of MBF and diabetic duration, diabetic complications, conventional risk factors, coronary calcium, and coronary stenosis were assessed by logistic regression analysis...
March 16, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29625153/brain-ct-perfusion-improves-intracranial-vessel-occlusion-detection-on-ct-angiography
#10
Marinus J Becks, Rashindra Manniesing, Jeroen Vister, Sjoert A H Pegge, Stefan C A Steens, Ewoud J van Dijk, Mathias Prokop, Frederick J A Meijer
BACKGROUND AND PURPOSE: To evaluate whether brain CT perfusion (CTP) aids in the detection of intracranial vessel occlusion on CT angiography (CTA) in acute ischemic stroke. MATERIALS AND METHODS: Medical-ethical committee of our hospital was obtained and informed consent was waived. Patients suspected of acute ischemic stroke who underwent non-contrast CT(NCCT), CTA and whole-brain CTP in our center in the year 2015 were included. Three observers with different levels of experience evaluated the imaging data of 110 patients for the presence or absence of intracranial arterial vessel occlusion with two strategies...
April 3, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29622554/slow-collateral-flow-is-associated-with-thrombus-extension-in-patients-with-acute-large-artery-occlusion
#11
R Zhang, Y Zhou, S Yan, S Zhang, X Ding, M Lou
BACKGROUND AND PURPOSE: It is still poorly understood about the dynamic changes of the thrombus after intravenous thrombolysis and how the remaining thrombus affects clinical outcome in human stroke. Collateral flow was assumed to help to deliver endo/exogenous tissue-type plasminogen activator to the clot. We aimed to analyze the impact of collateral flow on the dynamic changes of the thrombus in patients with acute large-artery occlusion who received intravenous thrombolysis. MATERIALS AND METHODS: We reviewed consecutive patients with acute ischemic stroke with M1 segment or distal internal carotid artery occlusion who underwent multimodal MR imaging or CT perfusion before and 24 hours after intravenous thrombolysis without recanalization...
April 5, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29613843/intraprocedural-ablation-margin-assessment-by-using-ammonia-perfusion-pet-during-fdg-pet-ct-guided-liver-tumor-ablation-a-pilot-study
#12
Paul B Shyn, Leigh C Casadaban, Nisha I Sainani, Cheryl A Sadow, Paul M Bunch, Vincent M Levesque, Chun K Kim, Victor H Gerbaudo, Stuart G Silverman
Purpose To prospectively determine whether nitrogen 13 (13 N) ammonia perfusion positron emission tomography (PET) during fluorine 18 fluorodeoxyglucose (FDG) PET/computed tomography (CT)-guided liver tumor ablation can be used to intraprocedurally assess ablation margins. Materials and Methods Eight patients (five women and three men; age range, 36-74 years; mean age, 57 years) were enrolled in this pilot study and underwent FDG PET/CT-guided microwave ablation of 11 FDG-avid liver metastases (mean diameter, 22 mm; range, 11-34 mm)...
April 3, 2018: Radiology
https://www.readbyqxmd.com/read/29602726/does-enhancement-or-perfusion-on-preprocedure-ct-predict-outcomes-after-embolization-of-hepatocellular-carcinoma
#13
Alessandra Borgheresi, Adrian Gonzalez-Aguirre, Karen T Brown, George I Getrajdman, Joseph P Erinjeri, Anne Covey, Hooman Yarmohammadi, Etay Ziv, Constantinos T Sofocleous, Franz Edward Boas
RATIONALE AND OBJECTIVE: The objective of this study was to evaluate whether quantitative enhancement or perfusion measurements on preprocedure triphasic computed tomography (CT) can be used to predict response or overall survival after embolization of hepatocellular carcinoma. MATERIALS AND METHODS: The institutional review board approved this retrospective review of 63 patients with hepatocellular carcinoma treated with particle embolization between March 2009 and December 2014...
March 27, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29594931/validation-of-18-f-flt-as-a-perfusion-independent-imaging-biomarker-of-tumour-response-in-egfr-mutated-nsclc-patients-undergoing-treatment-with-an-egfr-tyrosine-kinase-inhibitor
#14
R Iqbal, G M Kramer, V Frings, E F Smit, O S Hoekstra, R Boellaard
BACKGROUND: 3'-Deoxy-3'-[18 F]fluorothymidine ([18 F]FLT) was proposed as an imaging biomarker for the assessment of in vivo cellular proliferation with positron emission tomography (PET). The current study aimed to validate [18 F]FLT as a perfusion-independent PET tracer, by gaining insight in the intra-tumoural relationship between [18 F]FLT uptake and perfusion in non-small cell lung cancer (NSCLC) patients undergoing treatment with a tyrosine kinase inhibitor (TKI). Six patients with metastatic NSCLC, having an activating epidermal growth factor receptor (EGFR) mutation, were included in this study...
March 27, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29588567/dual-energy-single-source-ct-coronary-perfusion-angiography-a-helpful-functional-adjunct-to-anatomical-information
#15
A Canning, S Hughes, J A Purvis
No abstract text is available yet for this article.
January 2018: Ulster Medical Journal
https://www.readbyqxmd.com/read/29582878/value-of-transluminal-attenuation-gradient-of-stress-ccta-for-diagnosis-of-haemodynamically-significant-coronary-artery-stenosis-using-wide-area-detector-ct-in-patients-with-coronary-artery-disease-comparison-with-stress-perfusion-cmr
#16
Hee Yeong Kim, Hwan Seok Yong, Eung Ju Kim, Eun-Young Kang, Bo Kyoung Seo
INTRODUCTION: This study aimed to evaluate the value of transluminal attenuation gradient (TAG) of stress coronary computed tomography angiography (CCTA), using a wide-area detector CT in patients with coronary artery disease, compared to stress perfusion cardiac magnetic resonance (CMR) imaging. METHODS: This prospective study from May 2012 to January 2015 included 21 patients with moderate coronary stenosis on invasive coronary angiography. All patients underwent adenosine stress single-shot CCTA with a rest CCTA scan using a wide-area detector CT...
January 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29582129/evaluating-the-feasibility-of-isolated-pancreatic-perfusion-for-chemotherapy-using-computed-tomography-an-experimental-study-in-pig-models
#17
Satoru Murata, Shiro Onozawa, Daisuke Yasui, Tatsuo Ueda, Fumie Sugihara, Akira Shimizu, Kenichi Suzuki, Mitsuo Satake
PURPOSE: Percutaneous isolated pancreatic perfusion (PIPP) is performed along with interventional radiology techniques to obtain high drug concentration by occluding the arterial inlet and venous outlet of the pancreas. The experimental study aimed to evaluate the contrast distribution in PIPP under different flow rates with or without anterior mesenteric artery (AMA) occlusion. MATERIALS AND METHODS: This study was approved by a local animal experiment ethics committee...
March 26, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29581341/time-from-imaging-to-endovascular-reperfusion-predicts-outcome-in-acute-stroke
#18
Jenny P Tsai, Michael Mlynash, Soren Christensen, Stephanie Kemp, Sun Kim, Nishant K Mishra, Christian Federau, Raul G Nogueira, Tudor G Jovin, Thomas G Devlin, Naveed Akhtar, Dileep R Yavagal, Roland Bammer, Matus Straka, Gregory Zaharchuk, Michael P Marks, Gregory W Albers, Maarten G Lansberg
BACKGROUND AND PURPOSE: This study aims to describe the relationship between computed tomographic (CT) perfusion (CTP)-to-reperfusion time and clinical and radiological outcomes, in a cohort of patients who achieve successful reperfusion for acute ischemic stroke. METHODS: We included data from the CRISP (Computed Tomographic Perfusion to Predict Response in Ischemic Stroke Project) in which all patients underwent a baseline CTP scan before endovascular therapy...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29578912/stent-design-affects-femoropopliteal-artery-deformation
#19
Jason MacTaggart, William Poulson, Andreas Seas, Paul Deegan, Carol Lomneth, Anastasia Desyatova, Kaspars Maleckis, Alexey Kamenskiy
BACKGROUND: Poor durability of femoropopliteal artery (FPA) stenting is multifactorial, and severe FPA deformations occurring with limb flexion are likely involved. Different stent designs result in dissimilar stent-artery interactions, but the degree of these effects in the FPA is insufficiently understood. OBJECTIVES: To determine how different stent designs affect limb flexion-induced FPA deformations. METHODS: Retrievable markers were deployed into n = 28 FPAs of lightly embalmed human cadavers...
March 23, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29576877/effect-of-hemodialysis-on-eye-coats-axial-length-and-ocular-perfusion-pressure-in-patients-with-chronic-renal-failure
#20
Ling Wang, Gang Yin, Zhiying Yu, Nan Chen, Dabo Wang
Purpose: To investigate changes in eye coats, axial length, and ocular perfusion pressure (OPP) in hemodialysis (HD) patients with chronic renal failure (CRF). Methods: We included HD patients who were diagnosed with CRF in our hospital from January to December 2015. Fifty-two patients met the inclusion criteria; all right eyes were used for observation. Systolic and diastolic blood pressures were recorded to calculate OPP. Approximately 30 minutes before and after HD, we recorded multiple parameters, including lens thickness (LT), axial length of vitreous (VAL), axial length of eye (EAL), ciliary body thickness (CBT), choroidal thickness (CT), and retinal thickness (RT)...
2018: Journal of Ophthalmology
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