Shubhadeep D Sinha, Avula Rajamma, Mohan Reddy Bandi, Sreenivasa Chary Sriramadasu, Suvash Sahu, Raj Kumar Kothiwala, Saswati Halder, Abhilash Sankerneni, Muralidhar Panapakam, Venkata Narayana Reddy Vemireddy, Ramya Vattipalli, Srinivas Reddy Devireddy
BACKGROUND AND OBJECTIVE: Naftifine, an allylamine, is highly effective against tinea pedis and exhibits relatively greater affinity to skin and nail beds, possibly due to its high lipophilicity. To study the efficacy and safety of naftifine 2% gel in an Indian population, a phase III multicentre double-blind, comparative, parallel-group study was conducted in comparison with miconazole 2% gel in patients with interdigital tinea pedis, with mild to moderate symptoms. PATIENTS AND METHODS: Patients presenting with mild to moderate signs and symptoms of interdigital tinea pedis and mycologically confirmed tinea infection were randomised to either naftifine hydrochloride 2% gel (n = 112) or miconazole 2% gel (n = 112) in 1:1 ratio...
July 2023: Clinical Drug Investigation