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https://www.readbyqxmd.com/read/28416557/terbinafine-resistance-of-trichophyton-clinical-isolates-caused-by-specific-point-mutations-in-the-squalene-epoxidase-gene
#1
Tsuyoshi Yamada, Mari Maeda, Mohamed Mahdi Alshahni, Reiko Tanaka, Takashi Yaguchi, Olympia Bontems, Karine Salamin, Marina Fratti, Michel Monod
Terbinafine is one of the allylamine antifungal agents, whose target is squalene epoxidase (SQLE). This agent has been extensively used in the therapy of dermatophyte infections. The incidence of patients with tinea pedis or unguium tolerant to terbinafine treatment prompted us to screen terbinafine resistance of all Trichophyton clinical isolates from the laboratory of Centre Hospitalier Universitaire Vaudois collected over a three-year period, and to identify their mechanism of resistance. Among 2056 tested isolates, 17 (≈ 1%) showed reduced terbinafine susceptibility, all of which were found to harbor SQLE gene alleles with different single point mutations, leading to single amino acid substitutions at one of four positions (Leu(393), Phe(397), Phe(415) and His(440)) of the SQLE protein...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28405739/dermatological-comorbidity-in-psoriasis-results-from-a-large-scale-cohort-of-employees
#2
N Zander, I Schäfer, M Radtke, A Jacobi, H Heigel, M Augustin
The field of dermatological comorbidity in psoriasis is only passively explored with contradictory results. Objective of this study was to further investigate the complex field of psoriasis and associated skin diseases by identifying skin comorbidity patterns in an extensive cohort of employees in Germany. Retrospective analysis of data deriving from occupational skin cancer screenings was conducted. From 2001 to 2014 German employees between 16 and 70 years from different branches underwent single whole-body screenings by trained dermatologists in their companies...
April 12, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28379097/examining-the-accuracy-of-visual-diagnosis-of-tinea-pedis-and-tinea-unguium-in-aged-care-facilities
#3
T Goto, G Nakagami, K Takehara, T Nakamura, M Kawashima, Y Tsunemi, H Sanada
OBJECTIVE: The aim of this study was to examine the accuracy of visual diagnosis of tinea pedis (Athlete's foot) and tinea unguium (fungal nail infection), as well as to provide information on skin abnormalities that could help identify these diseases in aged care facilities (long-term care facilities (LTCFs) and nursing homes). METHOD: A multicentre, cross-sectional observational study was conducted in a LTCF and two nursing homes. A dermatologist observed the skin abnormalities in the participants' interdigital and plantar areas, to screen for tinea pedis, and in the participants' toenails, to screen for tinea unguium...
April 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28329539/gyrate-erythema-in-the-setting-of-tinea-pedis
#4
Kathryn Myers, Vitaly Terushkin, Shane A Meehan, David E Cohen
Gyrate erythema, which also is known as erythemaannulare centrifugum (EAC), is a reactive dermatitisthat is thought to occur in response to an underlyingtrigger. The superficial form is characterized bythe typical, centrifugally-expanding, annular,erythematous patches or plaques with a distincttrailing scale. The deep form also is a centrifugallyexpanding,erythematous plaque but with induratedborders and absence of scale. These cutaneousfindings are thought to be reactive, most often inresponse to infections or drugs and, less likely, tounderlying malignant conditions...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28188317/malodorous-discharge-redness-and-crusting-of-the-feet
#5
Alberto Marcelin, Jasmine R Marcelin, Larry M Baddour, Mark Davis
This man was initially treated with antifungals and antibiotics based on his history of tinea pedis. But 2 days later, his condition worsened and he was hospitalized.
January 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28188051/incidence-and-biodiversity-of-yeasts-dermatophytes-and-non-dermatophytes-in-superficial-skin-infections-in-assiut-egypt
#6
A H Moubasher, M A Abdel-Sater, Z Soliman
OBJECTIVE: The aim was to identify the incidence of the causal agents from dermatophytes, non-dermatophytes and yeasts in Assiut Governorate employing, beside the morphological and physiological techniques, the genotypic ones. PATIENTS: Samples from infected nails, skin and hair were taken from 125 patients. MATERIALS AND METHODS: Patients who presented with onychomycosis, tinea capitis, tinea corporis, tinea cruris and tinea pedis during the period from February 2012 to October 2015 were clinically examined and diagnosed by dermatologists and were guided to Assiut University Mycological Centre for direct microscopic examination, culturing and identification...
February 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28101694/relationship-between-phenotypic-and-genotypic-characteristics-of-trichophyton-mentagrophytes-strains-isolated-from-patients-with-dermatophytosis
#7
I Dhib, I Khammari, A Yaacoub, F Hadj Slama, M Ben Saïd, R Zemni, A Fathallah
According to epidemiological, clinical and mycological criteria, it has long been admitted that the Trichophyton mentagrophytes species includes two varieties: a zoophilic variety (var. mentagrophytes) and an anthropophilic variety (var. interdigitale) that involve the upper and the lower part of the body, respectively. The further application of molecular techniques to the characterization of dermatophyte strains showed that this classification is unreliable. The aim of our study was to assess the usefulness of PCR-RFLP (restriction fragment length polymorphism) and sequencing in the characterization of T...
January 18, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28004227/trichophyton-rubrum-infection-characterized-by-majocchi-s-granuloma-and-deeper-dermatophytosis-case-report-and-review-of-published-literature
#8
Huilin Su, Li Li, Benlin Cheng, Junhao Zhu, Qiangqiang Zhang, Jinhua Xu, Min Zhu
Infections caused by Trichophyton rubrum are very common in dermatological disease. It most often appears as superficial cutaneous mycosis, such as tinea manuum, tinea pedis, and tinea corporis. However, deep infection caused by T. rubrum was rarely reported. We describe a case of mixed type of deep infection caused by T. rubrum in a 45-year-old man with no significant immunodeficiency. This patient had a history of onychomycosis on the toenails without regular treatment for nearly 6 years. And, he had erythema, papule, and nodules on the submandibular area, neck, and chest for almost 1 year...
December 21, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27936071/foot-conditions-among-homeless-persons-a-systematic-review
#9
Matthew J To, Thomas D Brothers, Colin Van Zoost
INTRODUCTION: Foot problems are common among homeless persons, but are often overlooked. The objectives of this systematic review are to summarize what is known about foot conditions and associated interventions among homeless persons. METHODS: A literature search was conducted on MEDLINE (1966-2016), EMBASE (1947-2016), and CINAHL (1982-2016) and complemented by manual searches of reference lists. Articles that described foot conditions in homeless persons or associated interventions were included...
2016: PloS One
https://www.readbyqxmd.com/read/27904054/epidemiology-of-dermatophytoses-in-crete-greece
#10
Sofia Maraki, Viktoria Eirini Mavromanolaki
Dermatophytoses are among the most frequently diagnosed skin infections worldwide. However, the distribution of pathogenic species and the predominating anatomical sites of infection vary with geographical location and change over time. The aim of this study was to determine the epidemiological and aetiological factors of dermatophytoses in Crete, Greece over the last 5-year period (2011-2015) and their incidence in relation to the gender and the age of the patients. We compared our findings with those previously reported from the same area and from other parts of the world...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27864837/risk-factors-for-non-purulent-leg-cellulitis-a-systematic-review-and-meta-analysis
#11
REVIEW
M Quirke, F Ayoub, A McCabe, F Boland, B Smith, R O'Sullivan, A Wakai
Non-purulent cellulitis is an acute bacterial infection of the dermal and subdermal tissues that is not associated with purulent drainage, discharge or abscess. The objective of this systematic review and meta-analysis (SRMA) was to identify and appraise all controlled observational studies that have examined risk factors for the development of non-purulent cellulitis of the leg (NPLC). A systematic literature search of electronic databases and grey literature sources was performed in July 2015. The Newcastle-Ottawa Scale (NOS) was used to assess methodological quality of included studies...
November 18, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27843933/onychomycosis-practical-approaches-to-minimize-relapse-and-recurrence
#12
REVIEW
Antonella Tosti, Boni E Elewski
INTRODUCTION: Toenail onychomycosis is a common disease in which treatment options are limited and treatment failures and disease recurrence are frequently encountered. It usually requires many months of treatment, and recurrence may occur in more than half of the patients within 1 year or more after the infection has been eradicated. Data on long-term treatment, follow-up and recurrence are limited. OBJECTIVE: Our objective is to interpret these data and recommend practical approaches that should minimize recurrence based on our clinical experience...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27825175/update-on-efinaconazole-10-topical-solution-for-the-treatment-of-onychomycosis
#13
A K Gupta, C Studholme
Efinaconazole 10% nail solution is a novel topical antifungal drug for the treatment of onychomycosis. Two Phase III trials were completed using efinaconazole 10% nail solution, where 17.8% and 15.2% of patients achieved complete cure, and 55.2% and 53.4% achieved mycological cure. Several post hoc analyses were carried out using data from Phase III trials to determine the efficacy of efinaconazole with respect to disease duration, disease progression, and comorbidities of diabetes or tinea pedis with onychomycosis...
November 2016: Skin Therapy Letter
https://www.readbyqxmd.com/read/27799613/mycosis-fungoides-mimicking-tinea-pedis
#14
Steven A Hanna, Mark G Kirchhof
No abstract text is available yet for this article.
December 6, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27667305/prevalence-and-epidemiology-of-tinea-pedis-and-toenail-onychomycosis-and-antifungal-susceptibility-of-the-causative-agents-in-patients-with-type%C3%A2-2-diabetes-in-turkey
#15
Yasemin Oz, Iman Qoraan, Ali Oz, Ilknur Balta
BACKGROUND: Diabetes patients are particularly susceptible to fungal infections because their vascular and immunological systems are compromised. OBJECTIVES: The present study aimed to determine prevalences of tinea pedis and onychomycosis, factors predisposing to their development, and antifungal susceptibilities of causative fungal species against fluconazole, itraconazole, and terbinafine in patients with type 2 diabetes mellitus (DM). METHODS: Study groups were defined according to hemoglobin A1C rates of ≥6...
January 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27666873/enhancement-of-the-topical-tolnaftate-delivery-for-the-treatment-of-tinea-pedis-via-provesicular-gel-systems
#16
Mona Mahmoud AbouSamra, Alaa Hamed Salama
Tolnaftate is a thiocarbamate antifungal drug which is therapeutically active against dermatophytes that cause various forms of tinea. Due to the small amount of tolnaftate released from ordinary ointment bases and insufficient penetration through the infected skin layers the need to incorporate the drug in a more suitable pharmaceutical form has evolved. A provesicular system is one such form that can solve these problems. Once in contact with the skin, dilution with moisture occurs and the provesicular system rapidly transforms into a vesicular one...
October 19, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27648034/tinea-pedis-and-onychomycosis-frequency-in-diabetes-mellitus-patients-and-diabetic-foot-ulcers-a-cross-sectional-observational-study
#17
Gamze Akkus, Mehtap Evran, Dilek Gungor, Mehmet Karakas, Murat Sert, Tamer Tetiker
OBJECTIVE: Impaired cellular immunity and reduced phagocytic function of polymorphonuclear leukocytes facilitate the development of skin fungal and bacterial infections due to uncontrolled hyperglycemia in diabetic patients. In our study, we aimed to assess onychomycosis and/or tinea pedis frequency in diabetic patients, and effects on the development of chronic complications, particularly foot ulcer. METHODS: We included 227 diabetic patients in the study. Forty-three patients had diabetic foot ulcer...
July 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27602974/econazole-nitrate-foam-1-improves-the-itch-of-tinea-pedis
#18
Alan B Fleischer, Isabelle Raymond
Econazole nitrate topical foam, 1%, is indicated for the treatment of interdigital tinea pedis caused by <em>Trichophyton rubrum, Trichophyton mentagrophytes,</em> and <em>Epidermophyton floccosum</em> in patients 12 years of age and older. The symptom of itch or pruritus was evaluated in two randomized, double-blind, parallel-group, vehicle-controlled, multicenter Phase III studies in which econazole foam was compared with foam vehicle in subjects with interdigital tinea pedis. A thin, uniform layer of study treatment was applied once daily to all clinically affected interdigital regions of both feet for four weeks...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27537822/tinea-and-onychomycosis
#19
Theodore Rosen
Onychomycosis and tinea pedis are common fungal infections affecting the nails and feet, respectively. Two newly approved topical agents for onychomycosis are efinaconazole and tavaborole, both of which have demonstrated respectable cure rates in clinical studies. For tinea pedis, naftifine 2% and luliconazole 1% are new agents, both administered for relatively short courses, that may foster greater adherence Semin Cutan Med Surg 35(supp6):S110-S113.
June 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27520535/epidemiological-trends-of-dermatophytosis-in-tehran-iran-a-five-year-retrospective-study
#20
S Zamani, G Sadeghi, F Yazdinia, H Moosa, A Pazooki, Z Ghafarinia, M Abbasi, M Shams-Ghahfarokhi, M Razzaghi-Abyaneh
OBJECTIVE: Dermatophytosis is the most frequent fungal infection all over the world and its frequency is constantly increasing. The aim of this study was to evaluate clinical features and epidemiological trends of dermatophytosis over the years 2010 to 2014 in Tehran, Iran. PATIENTS AND METHODS: A total of 13,312 patients clinically suspected of cutaneous fungal infections were examined. Skin scales, plucked hairs, nail clippings and sub-ungual debris were examined by direct microscopy and culture...
December 2016: Journal de Mycologie Médicale
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