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cervical cancer 1b1

Alessandro Buda, Andrea Papadia, Ignacio Zapardiel, Enrico Vizza, Fabio Ghezzi, Elena De Ponti, Andrea Alberto Lissoni, Sara Imboden, Maria Dolores Diestro, Debora Verri, Maria Luisa Gasparri, Beatrice Bussi, Giampaolo Di Martino, Begoña Diaz de la Noval, Michael Mueller, Cinzia Crivellaro
BACKGROUND: The credibility of sentinel lymph node (SLN) mapping is becoming increasingly more established in cervical cancer. We aimed to assess the sensitivity of SLN biopsy in terms of detection rate and bilateral mapping in women with cervical cancer by comparing technetium-99 radiocolloid (Tc-99(m)) and blue dye (BD) versus fluorescence mapping with indocyanine green (ICG). METHODS: Data of patients with cervical cancer stage 1A2 to 1B1 from 5 European institutions were retrospectively reviewed...
September 2016: Annals of Surgical Oncology
Alessandro Buda, Federica Elisei, Sharon Palazzi, Elena De Ponti, Maurizio Arosio, Francesca Vecchione, Tiziana Dell'Anna, Marco Cuzzocrea, Beatrice Bussi, Daniela Giuliani, Giampaolo Di Martino, Cinzia Crivellaro
OBJECTIVES: The purpose of this study was to assess the quality of care in patients who underwent sentinel lymph node (SLN) mapping for endometrial and cervical cancer staging, and evaluate the impact of different techniques on patient satisfaction, i.e. radiotracer Tc99m versus indocyanine green (ICG) or methylene blue injection. METHOD: Women with preoperative stage I endometrial cancer or stage I (1A2-1B1) cervical cancer who underwent surgical staging, including SLN mapping, were considered for this study...
September 2016: Annals of Surgical Oncology
Miseon Kim, Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Masahito Mizuuchi, Sakura Takada, Tsuyoshi Saito
AIM: Radical trachelectomy (RT) with lymphadenectomy has become a standard treatment modality for patients with early invasive uterine cervical cancer who hope to preserve fertility. However, pregnancy after RT has high risks of preterm birth. The possibility of more conservative RT and the application of RT for patients with higher clinical stages were studied. METHODS: The medical charts and specimens of 42 patients who underwent RT and 64 patients who underwent radical hysterectomy were retrospectively studied...
July 2016: Journal of Obstetrics and Gynaecology Research
Ferenc Lakosi, Marjoelin de Cuypere, Paul Viet Nguyen, Nicolas Jansen, Bernard Warlimont, Akos Gulyban, Christine Gennigens, Laurence Seidel, Katty Delbecque, Philippe Coucke, Johanne Hermesse, Frederic Kridelka
BACKGROUND: To evaluate efficacy and toxicity of radio-chemotherapy (RCT) and MR-guided pulsed-dose-rate (PDR) adaptive brachytherapy (IGABT) for locally advanced cervical cancer (LACC). MATERIAL AND METHODS: Between 2007 and 2014 85 patients with FIGO stage 1B1 N+ or ≥ 1B2 cervical cancer were treated with RCT+ IGABT. The treatment consisted of a pelvic± paraaortic external beam radiotherapy (EBRT) (45-50.4 Gy ± 10 Gy boost to primary tumor and/or to pathologic lymph nodes) with concurrent cisplatin followed by 25-35 Gy of PDR IGABT in 30-50 pulses...
2015: Acta Oncologica
Nasuh Utku Dogan, Nigar Garagozova, Tatiana Pfiffer, Anna Beier, Christhardt Köhler, Giovanni Favero
In early stage cervical cancer, nodal status is the most important prognostic factor, and execution of retroperitoneal lymphadenectomy is currently an integral part of surgical therapy. Sentinel lymph node biopsy has been progressively incorporated with surgical therapy and could reduce morbidity. However, the current incidence of complications exclusively related to the procedure is unknown. We report on a 29-year-old woman affected by cervical cancer (Fédération Internationale de Gynécologie et d'Obstétrique Stage 1b1), who underwent sentinel lymph node biopsy in combination with radical vaginal trachelectomy, and who later developed a symptomatic pelvic lymphocele that required surgical therapy...
March 2016: Journal of Minimally Invasive Gynecology
Narine Grove, Ma Zheng, Robert E Bristow, Ramez N Eskander
BACKGROUND: Positron emission tomography (PET) fused with computed tomography (CT) imaging is common in the clinical assessment of patients with locally advanced cervical cancer. Limitations to the utilization and interpretation of PET-CT scans in patients with cervical cancer have been described, including false-positive findings secondary to tattoo ink. CASE: A 32-year-old woman presented with clinical stage 1B1 cervical cancer and extensive tattoos of the lower extremities...
July 2015: Obstetrics and Gynecology
Jyoti Mayadev, Chin-Shang Li, Jihoon Lim, Richard Valicenti, Edwin A Alvarez
PURPOSE: We examined the incidence and the effect of alcohol abuse on pelvic control (PC), disease-free survival (DFS), and overall survival (OS) in locally advanced cervical cancer patients undergoing definitive radiation therapy (RT). METHODS: Between 2007 and 2013, 95 patients treated with RT were reviewed, and the tumor characteristics, the RT dose, the treatment time, chemotherapy, and the number of cycles were recorded. The association between alcohol abuse and DFS, OS, and the duration of PC was analyzed using multivariable Cox proportional hazards models...
March 13, 2015: American Journal of Clinical Oncology
Hideki Tokunaga, Yoh Watanabe, Hitoshi Niikura, Satoru Nagase, Masafumi Toyoshima, Reiji Shiro, Yoshihito Yokoyama, Hideki Mizunuma, Tsuyoshi Ohta, Hiroshi Nishiyama, Takafumi Watanabe, Naoki Sato, Naoto Sato, Toru Sugiyama, Tadao Takano, Fumiaki Takahashi, Nobuo Yaegashi
BACKGROUND: This study aimed to evaluate surgical, pregnancy, and prognostic outcomes of radical abdominal trachelectomy (RAT) for Japanese patients with early-stage cervical cancer. METHODS: This was a multicenter prospective cohort study conducted in member facilities of Tohoku Gynecologic Cancer Unit. Patients with FIGO 1A-1B1 squamous cell carcinoma were included. RESULTS: A total of 42 patients were registered in this study, and all patients underwent planned RAT...
August 2015: International Journal of Clinical Oncology
Chloe Barr, Thumuluru Kavitha Madhuri, Pradeep Prabhu, Simon Butler-Manuel, Anil Tailor
INTRODUCTION: We present an unusual complication following robotic assisted radical hysterectomy. CASE REPORT: A 51-year-old female with stage 1B1 cervical cancer underwent a robotic assisted radical hysterectomy. The procedure was prolonged with difficulties dissecting the left parametrium and vaginal fornix with persistent bleeding from the left vaginal vault. Post-operatively the patient was electively sedated and ventilated. Extubation was difficult due to patient agitation but achieved on day 2...
November 2014: Archives of Gynecology and Obstetrics
Dearbhail O Driscoll, Darragh Halpenny, Ciaran Johnston, Niall Sheehy, Mary Keogan
PURPOSE: To assess the clinical benefit of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG-PET/CT) in evaluating pelvic lymph nodes in patients with early stage cervical cancer (FIGO stage 1a–1b1), who have magnetic resonance imaging (MRI)-defined lymph node negative disease, with histopathologic results as the reference standard. MATERIALS AND METHODS: We assessed one hundred and seventy nine sequential 18F-FDG-PET/CT scans in women with newly diagnosed cervical carcinoma between January 2009 and September 2011...
January 2015: Abdominal Imaging
Geneviève Bouchard-Fortier, Clare J Reade, Allan Covens
OBJECTIVES: Non-radical surgery has been proposed in women with early-stage cervical cancer to reduce morbidity. Our objective was to evaluate the outcomes of women with early-stage cervical cancer treated with non-radical surgery. METHODS: Between March 1991 and July 2013, 51 women with early-stage cervical cancer underwent simple hysterectomy or cone biopsy. All patients had assessment of pelvic lymph nodes. Patient demographics, stage, perioperative complications, pathology findings and disease-free interval were collected prospectively...
March 2014: Gynecologic Oncology
Tae-Gyu Ahn, Byoung-Rai Lee, Jong-Ki Kim, Bum-Chae Choi, Sei-Jun Han
► Photodynamic therapy can treat lesions with highly reactive single oxygen. ► CCPDT (Concurrent Chemo Photodynamic Therapy) is defined as PDT with chemotherapy. ► CCPDT can treat larger and deeper lesions than PDT due to PCI concept. ► Complete remission would be possible in uterine cervical cancer by CCPDT. ► Uterine cervix and corpus can be preserved in CCPDT.
2012: Gynecologic Oncology Case Reports
E C Brockbank, J Evans, N Singh, J H Shepherd, A R Jeyarajah
► Post cervical cancer treatment new pelvic abnormality must be regarded as recurrence. ► Benign MRI features does not exclude recurrence from previous cervical adenocarcinoma.
2012: Gynecologic Oncology Case Reports
Ya Li, Shi-Qiao Tan, Qian-Hong Ma, Lei Li, Zhong-Ying Huang, Yan Wang, Shang-Wei Li
Cytochrome P450 1B1 (CYP1B1) is a key P450 enzyme, which could catalyze the formation of 4-hydroxy estrogen metabolites and play a role in estrogen-dependent cancers. We hypothesized that genetic variant in CYP1B1 may modify individual susceptibility to cervical cancer. The aim of this study was to evaluate the association between CYP1B1 C4326G polymorphism and cervical cancer risk in Chinese women. We extracted the peripheral blood samples in 250 patients with cervical cancer and 250 female controls. The matrix-assisted laser desorption ionization time-of-flight mass spectrometry method and direct DNA sequencing were performed to detect the polymorphism...
December 2013: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Antonio Pellegrino, Gianluca Raffaello Damiani, Massimo Tartagni, Daniele Speciale, Mario Villa, Ciro Sportelli, Silvia Corso, Maria Grazia Pezzotta
In this prospective analysis, the feasibility and outcome of isobaric laparoscopy in gynecologic oncology was evaluated. Total laparoscopic radical hysterectomy type A and B, with or without pelvic lymphadenectomy, according to the Querleu-Morrow classification was performed in 22 consecutive patients. Seven patients had early cervical cancer (adenocarcinoma stage 1B1 in 1, and squamous carcinoma stage 1B1 in 4, stage 1A2 in 1, and stage 1B2 in 1), and 15 patients had endometrial cancer (stage IA in 4, stage IB in 9, and stage IIIA in 2)...
September 2013: Journal of Minimally Invasive Gynecology
Takuro Ariga, Takafumi Toita, Goro Kasuya, Yutaka Nagai, Morihiko Inamine, Wataru Kudaka, Yasumasa Kakinohana, Youichi Aoki, Sadayuki Murayama
The purpose of this study was to retrospectively analyze the treatment results of boost external beam radiotherapy (EBRT) to clinically positive pelvic nodes in patients with uterine cervical cancer. The study population comprised 174 patients with FIGO stages 1B1-4A cervical cancer who were treated with definitive radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT). Patients with positive para-aortic or common iliac nodes (≥10 mm in the shortest diameter, as evaluated by CT/MRI) were ineligible for the study...
July 1, 2013: Journal of Radiation Research
Qian Liu, Jia-xin Yang, Dong-yan Cao, Keng Shen, Ming Wu, Ling-ya Pan, Yang Xiang, Jing-he Lang
OBJECTIVE: To explore the low-risk indicators of early cervical cancer. METHODS: The medical records of 201 patients undergoing radical surgery between March 2000 and April 2011 for staging Ia2,Ib1 (tumor diameter≤2cm) cervix cancer were retrospectively reviewed, with particular focus on the pathological findings [parametrial involvement, positive margin, positive pelvic lymph node, and lymph vascular space invasion (LVSI)], treatment, and outcomes. RESULTS: The operation duration ranged 75-330min (mean:188...
December 2012: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Sonya Naryshkin, R Marshall Austin
OBJECTIVE: To increase awareness of the limitations of high-risk human papillomavirus (hrHPV) laboratory-developed testing (LDT) widely used in US cervical cancer screening. METHODS AND RESULTS: A young woman in her 30s was diagnosed and treated for stage 1B1 cervical squamous cell carcinoma in which HPV 16 DNA was detected using polymerase chain reaction testing. Both 1 month before and 42 months before cervical cancer diagnosis, the patient had highly abnormal cytology findings; however, residual SurePath™ (Becton, Dickson and Company, Franklin Lakes, NJ) vial fluid yielded negative Hybrid Capture 2 (HC2; Qiagen NV, Hilden, Germany) hrHPV LDT results from each of the two specimens...
2012: Drug, Healthcare and Patient Safety
P Karkhanis, A Patel, K Galaal
BACKGROUND: Urinary fistulas are a well-recognised complication of radical gynaecological oncology surgery for cervical cancer. Reported incidence varies between 0.6 and 5.1%. METHODS: A retrospective case-note review of vesical and ureteric fistulas diagnosed in cases that underwent radical surgery for the new diagnosis of early stage cervical cancer between January 2000 and June 2010. RESULTS: A total of 323 radical procedures for cervical cancer were performed during the study period...
October 2012: European Journal of Surgical Oncology
Ioannis Biliatis, Ali Kucukmetin, Amit Patel, Nithya Ratnavelu, Paul Cross, Supratik Chattopadhyay, Khadra Galaal, Raj Naik
OBJECTIVE: Current surgical treatment of FIGO stage 1B1 cervical cancer is radical surgery. However, several reports have shown that for small tumours a more conservative approach can be as effective in terms of survival, whilst at the same time reducing the morbidity associated with removing the parametrium. The objective of our study was to report survival and obstetric outcomes following conservative management of small-volume stage 1B1 disease. METHODS: All patients with FIGO stage 1B1 cancer and estimated tumour volume of less than 500 mm(3) in a loop biopsy specimen were included in the study, irrespective of other histological characteristics...
July 2012: Gynecologic Oncology
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