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https://www.readbyqxmd.com/read/27926889/precision-medicine-diabetes-and-the-u-s-food-and-drug-administration
#1
Robert J Meyer
The U.S. Food and Drug Administration (FDA) has long sought to achieve the broader use of personalized medicine, which is better targeting of FDA-approved therapies through incorporating precise knowledge of a patient's underlying condition to therapies optimally chosen to match those needs. While some strides have been made in precision medicine-particularly in oncology and rare genetic diseases-most of the standard general medicine indications have yet to realize the benefits of precision-guided therapies...
November 2016: Diabetes Care
https://www.readbyqxmd.com/read/27926809/public-health-physicians-and-dentists-in-poland-results-from-public-health-workforce-pilot-study
#2
Dorota Cianciara, Katarzyna Lewtak, Maria Piotrowicz, Małgorzata Gajewska, Ewa Urban, Katarzyna Brukało
Background: Monitoring public health workforce is one of the essential functions of the public health system. Objective: The aim of the study was to identify the specialities for physicians and dentists related to public health in the years 1951-2013, and analyse of available data on physicians and dentists certified as public health specialists (PHS) in 2003-2015. Material and Methods: The historical analysis covers a relevant regulations of a minister in charge of health...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27926687/an-initiative-to-standardize-the-identification-of-and-acute-response-to-postoperative-lower-extremity-neurological-deficits-effects-on-provider-knowledge-confidence-and-communication-skills
#3
Peter B Derman, Sravisht Iyer, Matthew Garner, Steven Orr, Karla J Felix, Allison Goldberg, Titilayo Ologhobo, Minlun Wu, Laura Robbins, Charles Cornell
BACKGROUND: Although relatively uncommon, neurological deficits following hip and knee arthroplasty can have permanent and debilitating consequences. This study was conducted to quantify the effectiveness of an educational curriculum aimed at standardizing the identification of and acute response to postoperative neurological deficits in the inpatient setting, specifically with respect to improvements in clinician knowledge, confidence levels, and communication skills. METHODS: A multidisciplinary committee at a single, high-volume academic institution created an algorithm delineating the appropriate clinical actions and escalation procedures in the setting of a postoperative neurological deficit for each clinical practitioner involved in care for patients who undergo arthroplasty...
December 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27925894/prevention-of-herpes-zoster-and-its-complications-from-clinical-evidence-to-real-life-experience
#4
Giovanni Gabutti, Paolo Bonanni, Michele Conversano, Guido Fanelli, Elisabetta Franco, Donato Greco, Giancarlo Icardi, Marzia Lazzari, Alessandro Rossi, Silvestro Scotti, Antonio Volpi
Herpes zoster (HZ) is an acute viral illness characterized by a vesicular rash with unilateral distribution, which can also result in severe complications such as post-herpetic neuralgia (PHN), ophthalmic zoster, stroke or other neurological complications. The estimate incidence in Europe ranges between 2.0 and 4.6 cases per 1,000 person-years, with a sharp increase in >50 year-old subjects. Currently, treatment options for HZ are only partially effective in limiting the acute phase, while the management of complications is complex and often unsatisfactory...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925771/heterosexual-homosexual-and-bisexual-men-s-pupillary-responses-to-persons-at-different-stages-of-sexual-development
#5
Janice Attard-Johnson, Markus Bindemann, Caoilte Ó Ciardha
This study investigated whether pupil size during the viewing of images of adults and children reflects the sexual orientation of heterosexual, homosexual, and bisexual men (n = 100, Mage = 22). More specifically, we explored whether this measure corresponds with sexual age preferences for adults over children in nonpedophilic men. In general, results across three experiments, in which observers freely viewed or rated the sexual appeal of person images, suggest that pupil dilation to sexual stimuli is an indicator of sexual orientation toward adults...
December 7, 2016: Journal of Sex Research
https://www.readbyqxmd.com/read/27925586/a-bayesian-additive-model-for-understanding-public-transport-usage-in-special-events
#6
Filipe Rodrigues, Stanislav Borysov, Bernardete Ribeiro, Francisco Pereira
Public special events, like sports games, concerts and festivals are well known to create disruptions in transportation systems, often catching the operators by surprise. Although these are usually planned well in advance, their impact is difficult to predict, even when organisers and transportation operators coordinate. The problem highly increases when several events happen concurrently. To solve these problems, costly processes, heavily reliant on manual search and personal experience, are usual practice in large cities like Singapore, London or Tokyo...
December 2, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/27925423/the-johns-hopkins-venous-thromboembolism-collaborative-multidisciplinary-team-approach-to-achieve-perfect-prophylaxis
#7
REVIEW
Michael B Streiff, Brandyn D Lau, Deborah B Hobson, Peggy S Kraus, Kenneth M Shermock, Dauryne L Shaffer, Victor O Popoola, Jonathan K Aboagye, Norma A Farrow, Paula J Horn, Hasan M Shihab, Peter J Pronovost, Elliott R Haut
Venous thromboembolism (VTE) is an important cause of preventable harm in hospitalized patients. The critical steps in delivery of optimal VTE prevention care include (1) assessment of VTE and bleeding risk for each patient, (2) prescription of risk-appropriate VTE prophylaxis, (3) administration of risk-appropriate VTE prophylaxis in a patient-centered manner, and (4) continuously monitoring outcomes to identify new opportunities for learning and performance improvement. To ensure that every hospitalized patient receives VTE prophylaxis consistent with their individual risk level and personal care preferences, we organized a multidisciplinary task force, the Johns Hopkins VTE Collaborative...
December 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/27925414/a-qualitative-study-of-healthcare-providers-perceptions-and-suggestions-for-developing-cancer-survivorship-care-models-in-south-korea
#8
J W Lim, E J Shon, E J Yang
This study aimed to explore healthcare providers' perceptions of the issues and problems as well as suggestions regarding the development of cancer survivorship care models in South Korea. An exploratory, descriptive, qualitative study was conducted with eight Korean healthcare providers using individual interviews. Purposive sampling was performed in a university hospital in Gyeonggi-do, Korea. Three concepts of the Chronic Care Model (CCM) were employed to identify the issues and problems with developing a survivorship care model for Korean cancer survivors...
December 7, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27925188/a-human-3d-in-vitro-model-to-assess-the-relationship-between-osteoporosis-and-dissemination-to-bone-of-breast-cancer-tumour-cells
#9
F Salamanna, V Borsari, S Brogini, P Torricelli, S Cepollaro, M Cadossi, M Fini
Despite consistent improvements in diagnostic and therapeutic strategies for breast cancer, up to 40% of patients will develop bone metastases. To reduce the morbidity and complications related with bone metastases, it is imperative to reduce their etiological factors. Osteoporosis, being characterized by a sudden estrogen deficiency, may provide a favorable condition for bone metastasis. This work, using a humanized 3D in vitro model, aims at evaluating the relationship between osteoporosis and breast cancer-derived bone metastases...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27925154/prenatal-exposure-to-maternal-bereavement-and-offspring-psoriasis-a-danish-nationwide-cohort-study
#10
X Liu, J Chen, J Olsen, V Schlünssen, N Momen, J Li
BACKGROUND: Prenatal stress may alter immune competence of the foetus. Limited data exist on the role of antenatal stress in psoriasis development. We aimed to investigate whether prenatal exposure to maternal bereavement increased the risk of offspring psoriasis. METHODS: This register-based cohort study included 1,811,917 live singletons born 1978-2008 in Denmark. The children were assigned to the bereaved group if their mothers lost a child, partner/spouse, a parent or a sibling during pregnancy or up to 12 months before pregnancy...
December 7, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27925116/truck-drivers-traffic-accidents-in-the-state-of-s%C3%A3-o-paulo-prevalence-and-predictors
#11
Lucio Garcia de Oliveira, Carlos Vinícius Dias de Almeida, Lucia Pereira Barroso, Marcela Julio Cesar Gouvea, Daniel Romero Muñoz, Vilma Leyton
Abstract The mortality rate of traffic accidents (TA) is high in Brazil. Trucks are the second category of motor vehicles most often involved in TA. However, few studies have addressed the issue of TA among these professionals. The study aimed to estimate the prevalence of TA and their predictors in a sample of 684 truck drivers recruited in the state of São Paulo during 2012 and 2013. We requested participants to answer a research instrument on their personal and occupational data and their involvement in TA and traffic violations...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925088/interdisciplinary-care-praxis-in-groups-of-people-living-with-fibromyalgia
#12
Nathália Aparecida Costa Guedes Miranda, Lina Márcia Miguéis Berardinelli, Vera Maria Sabóia, Irma da Silva Brito, Rosângela da Silva Santos
Objectives: to analyze the integrated community therapy model for the empowerment of people living with fibromyalgia and discuss the impact of this interdisciplinary intervention in the health-disease process and self-care. Method: a participatory-approach qualitative study, developed in 2015 with 11 participants at the Laboratory of Physiology Applied to Physical Education of the Rio de Janeiro State University, RJ. Data production comprised World Café, participant observation and semi-structured interview...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27924711/occupational-risk-factors-for-relapse-free-survival-in-bladder-cancer-patients
#13
Silvia Selinski, Hannah Bürger, Meinolf Blaszkewicz, Thomas Otto, Frank Volkert, Oliver Moormann, Hartmut Niedner, Jan G Hengstler, Klaus Golka
The influence of occupational risk factors on bladder cancer development is well investigated. However, studies on the influence on bladder cancer prognosis are rare. Therefore, it was of interest to investigate the time to first relapse in the follow-ups of three case-control series from Dortmund, Neuss, and Lutherstadt Wittenberg, Germany. Relapse-free survival of in total 794 urinary bladder cancer patients (Dortmund 174, Neuss 407, Lutherstadt Wittenberg 213) was derived from medical records. Cox regression models were used to determine the impact of profession and exposure to bladder carcinogens if the risk factor was present in at least four cases...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27924446/educational-encounters-of-the-third-kind
#14
Gonzalo Génova, M Rosario González
An engineer who becomes an educator in a school of software engineering has the mission to teach how to design and construct software systems, therein applying his or her knowledge and expertise. However, due to their engineering background, engineers may forget that educating a person is not the same as designing a machine, since a machine has a well-defined goal, whilst a person is capable to self-propose his or her own objectives. The ethical implications are clear: educating a free person must leave space for creativity and self-determination in his or her own discovery of the way towards personal and professional fulfillment, which cannot consist only in achieving goals selected by others...
December 6, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27924408/tackling-longitudinal-round-robin-data-a-social-relations-growth-model
#15
Steffen Nestler, Katharina Geukes, Roos Hutteman, Mitja D Back
The social relations model (SRM) is commonly used in the analysis of interpersonal judgments and behaviors that arise in groups. The SRM was developed only for use with cross-sectional data. Here, we introduce an extension of the SRM to longitudinal data. The social relations growth model represents a person's repeated SRM judgments of another person as a function of time. We show how the model's parameters can be estimated using restricted maximum likelihood, and how the effects of covariates on interindividual and interdyad variability in growth can be computed...
December 6, 2016: Psychometrika
https://www.readbyqxmd.com/read/27924406/estimating-legal-age-based-on-fusion-of-the-proximal-humeral-epiphysis
#16
María Benito Sánchez, Sónia Codinha, Alexandra Muñoz García, José Antonio Sánchez Sánchez
The increasing demand which requires ascertaining the legal age of undocumented individuals who reach the various countries of the European Community means that new lines of research must be developed which help respond to questions posed by the Justice Administration. For this reason, this study has been designed on the basis of fusion times of the proximal humeral epiphysis. Moreover, the ultrasound scan has been used as the diagnostic method. It is a non-invasive technique, unlike the radiograph, which is used under current standards for the forensic diagnosis of age...
December 6, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27924235/evaluation-of-related-risk-factors-in-number-of-musculoskeletal-disorders-among-carpet-weavers-in-iran
#17
Nasim Karimi, Abbas Moghimbeigi, Majid Motamedzade, Ghodratollah Roshanaei
BACKGROUND: Musculoskeletal disorders (MSDs) are a common problem among carpet weavers. This study was undertaken to introduce affecting personal and occupational factors in developing the number of MSDs among carpet weavers. METHODS: A cross-sectional study was performed among 862 weavers in seven towns with regard to workhouse location in urban or rural regions. Data were collected by using questionnaires that contain personal, workplace, and information tools and the modified Nordic MSDs questionnaire...
December 2016: Safety and Health At Work
https://www.readbyqxmd.com/read/27924148/impact-of-diagnosis-disclosure-on-adolescents-with-borderline-personality-disorder
#18
Darren B Courtney, Judy Makinen
OBJECTIVE: Establishing a diagnosis of Borderline Personality Disorder (BPD) in adolescents is often met with controversy, in part, due to potential stigmatizing effects. We wished to explore the adolescent patient experience of being diagnosed with BPD. METHOD: The Impact of Diagnosis Scale (IODS) is a self-report measure we developed with questions targeting patients' subjective experience of receiving a diagnosis of BPD. The IODS was administered to 23 adolescents approximately one month after a diagnosis of BPD had been disclosed to them...
2016: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27924065/the-more-the-messier-centrosome-amplification-as-a-novel-biomarker-for-personalized-treatment-of-colorectal-cancers
#19
REVIEW
Monica M Mahathre, Padmashree Cg Rida, Ritu Aneja
Colon cancer is currently the third most common cancer and second most fatal cancer in the United States, resulting in approximately 600,000 deaths annually. Though colorectal cancer death rates are decreasing by about 3% every year, disease outcomes could be substantially improved with more research into the drivers of colon carcinogenesis, the determinants of aggressiveness in colorectal cancer and the identification of biomarkers that could enable choice of more optimal treatments. Colon carcinogenesis is notably a slow process that can take decades...
November 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27924051/increased-stroke-burdens-among-the-low-income-young-and-middle-aged-in-rural-china
#20
Xianjia Ning, Jian Sun, Rongcai Jiang, Hongyan Lu, Lingling Bai, Min Shi, Jun Tu, Yanan Wu, Jinghua Wang, Jianning Zhang
BACKGROUND AND PURPOSE: Although stroke in the young and middle aged accounts for 31% of all strokes in China, the disease burden is unknown. We aimed to determine the secular trends in stroke incidence and the transition of subtypes in rural China over a 24-year period. METHODS: In 1992, 14 920 residents were recruited to participate in the Tianjin Brain Study. Stroke events and all deaths were registered annually. We assessed the trends in incidence of first-ever stroke, including intracerebral hemorrhage and ischemic stroke, among adults aged 35 to 64 years during 1992 to 1999, 2000 to 2007, and 2008 to 2015...
December 6, 2016: Stroke; a Journal of Cerebral Circulation
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