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https://www.readbyqxmd.com/read/25544116/beta-blockers-and-nitrates-pharmacotherapy-and-indications
#1
REVIEW
Emanuela Facchini, Anna Degiovanni, Chiara Cavallino, Alessandro Lupi, Andrea Rognoni, Angelo S Bongo
Many clinically important differences exist between beta blockers. B1-selectivity is of clinical interest because at clinically used doses, b1- selective agents block cardiac b-receptors while having minor effects on bronchial and vascular b-receptors. Beta-adrenergic blocking agents significantly decrease the frequency and duration of angina pectoris, instead the prognostic benefit of beta-blockers in stable angina has been extrapolated from studies of post myocardial infarction but has not yet been documented without left ventricular disfunction or previous myocardial infarction...
2015: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/23504480/the-efficacy-of-cardiac-findings-in-assessing-the-outcome-in-preterms-with-bronchopulmonary-dysplasia
#2
Abdullah Barış Akcan, Fırat Kardelen, Seyhan Erişir Oygucu, Abdullah Kocabaş, Deniz Ozel, Halide Akbaş, Nihal Oygür
OBJECTIVES: To evaluate if cardiac dysfunctions are important in assessing the outcome in newborns with Bronchopulmonary Dysplasia (BPD), by evaluating cardiac functions with N-terminal prohormone of brain natriüretic peptide (NT-proBNP) levels, M-mode and tissue doppler echocardiography at 6-12 mo of age. METHODS: Twenty eight patients were retrospectively classified as mild, moderate and severe according to the diagnostic criterias for BPD. All cases were assessed with standard M-mode, tissue doppler echocardiography and NT-proBNP levels...
November 2013: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/22010459/-acute-transient-left-ventricular-systolic-disfunction-during-alcohol-withdrawal
#3
Paweł Chwaluk, Robert Wróbel, Marek Kurianowicz
Stress cardiomyopathy is an acute transient left ventricular dysfunction, associated with emotional stress. In the course of alcohol withdrawal abnormalities of perfusion and myocardial contractility have been described, manifested in the scintigraphic study, with the absence of changes in ECG and echocardiography and probably caused by sympathicotony, in analogy to severe emotional stress. We present a case of acute left ventricular dysfunction during alcohol withdrawal with significant changes in echocardiography and ECG mimicking acute coronary syndrome...
2011: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/21394982/-state-of-art-on-the-role-of-ischemic-time-in-st-segment-elevation-myocardial-infarction-treated-with-ptca
#4
Daniele Berardi, Luciano Agati
Up till now ST-segment elevation myocardial infarction (STEMI) is an important clinical and epidemiological question because of its high incidence and death rate. In this light, intervention principles continue to be developed to reach a precise diagnosis and a fast transport of the patient towards adequate hospitals. As the only instrument able to modify the natural course of this disease is the early restoration of coronary flow in the myocardial ischemic area, we can understand that time to reperfusion is the driving parameter in defining sanitary and therapeutic ways aimed at facing up to this pathology in its acute phase and limiting the subsequent chronic disfunction...
December 2010: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/20518725/migraine-and-coronary-artery-disease-an-open-study-on-the-genetic-polymorphism-of-the-5-10-methylenetetrahydrofolate-mthfr-and-angiotensin-i-converting-enzyme-ace-genes
#5
V Pizza, A Bisogno, E Lamaida, A Agresta, G Bandieramonte, A Volpe, R Galasso, L Galasso, M Caputo, M F Tecce, A Capasso
Genetic factors that increase susceptibility to oxidative stress, endothelial disfunction and, possibly, stroke include angiotensin-converting enzyme gene deletion polymorphism (ACE-DD) and the methylentetrahydropholate reductase (MTHFR) C677-TT polymorphism. The relationship of ACE-DD genotype to ischemic stroke and cardiovascular disease is controversial, but it has been independently linked to lacunar infarction, in the absence of carotid atheroma. Lea et al. (2005) reported that the ACE DD genotype acts in combination with the MTHFR T/T genotype to increase migraine susceptibility, with the greatest effect in those with aura...
June 1, 2010: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/20144153/-evaluation-of-long-term-therapy-influence-with-angiotensin-converting-enzyme-inhibitor-lisinopril-on-morphofunctional-parameters-of-the-left-ventricle-peripheral-artery-endothelium-disfunction-and-painless-myocardial-ischemia-in-premenopausal-women-with-hypertension
#6
COMPARATIVE STUDY
M M Khabibulina
Aim of the study was to assess influence of long-term therapy with angiotensin converting enzyme inhibitor lisinopril on morphofunctional parameters of the left ventricle (LV) and painless myocardial ischemia in 109 premenopausal women with stage II hypertension depending on functional state of peripheral artery endothelium. The results show that lisinopril therapy in premenopausal women with hypertension can stop or even cause regression of LV myocardial hypertrophy and produce favorable effect on LV remodeling mostly in women with concentric type of hypertrophy and/or without endothelial dysfunction, and has positive effect on frequency of painless myocardial ischemia events...
2010: Kardiologiia
https://www.readbyqxmd.com/read/20126339/surgical-myocardial-revascularization-of-patients-with-ischemic-cardiomyopathy-and-severe-left-ventricular-disfunction
#7
André L Hovnanian, Alexandre de Matos Soeiro, Carlos Vicente Serrano, Sérgio Almeida de Oliveira, Fábio B Jatene, Noedir A G Stolf, José A F Ramires
OBJECTIVE: To determine long-term survival, identify preoperative factors predictive of a favorable outcome, and assess functional improvement after coronary artery bypass grafting in patients with advanced left ventricular dysfunction. METHODS: Between 1995 and 2001, 244 patients who underwent coronary artery bypass grafting and had a preoperative left ventricular ejection fraction less than or equal to 35% were included. left ventricular ejection fraction was determined by uniplanar or biplanar ventriculography during left heart catheterization...
2010: Clinics
https://www.readbyqxmd.com/read/20090424/molecular-remodeling-of-ion-channels-exchangers-and-pumps-in-atrial-and-ventricular-myocytes-in-ischemic-cardiomyopathy
#8
Naomi Gronich, Azad Kumar, Yuwei Zhang, Igor R Efimov, Nikolai M Soldatov
Existing molecular knowledge base of cardiovascular diseases is rudimentary because of lack of specific attribution to cell type and function. The aim of this study was to investigate cell-specific molecular remodeling in human atrial and ventricular myocytes associated with ischemic cardiomyopathy. Our strategy combines two technological innovations, laser-capture microdissection of identified cardiac cells in selected anatomical regions of the heart and splice microarray of a narrow catalog of the functionally most important genes regulating ion homeostasis...
March 2010: Channels
https://www.readbyqxmd.com/read/18991672/cardiac-metabolism-in-myocardial-ischemia
#9
REVIEW
Giuseppe M C Rosano, Massimo Fini, Giuseppe Caminiti, Giuseppe Barbaro
Myocardial ischemia occurs for a mismatch between blood flow and metabolic requirements, when the rate of oxygen and metabolic substrates delivery to the myocardium is insufficient to meet the myocardial energy requirements for a given myocardial workload. During ischemia, substantial changes occur in cardiac energy metabolism, as a consequence of the reduced oxygen availability. Some of these metabolic changes are beneficial and may help the heart adapt to the ischemic condition. However, most of the changes are maladaptive and contribute to the severity of the ischemic injury leading stunned or hibernating myocardium, cell death and ultimately to contractile disfunction...
2008: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/18508141/percutaneous-revascularization-in-patients-with-previous-coronary-artery-bypass-graft-surgery-immediate-and-1-year-clinical-outcomes
#10
Julio G Tejada, Maite Velazquez, Felipe Hernandez, Agustín Albarran, Ivan Gomez, Sergio Rodriguez, Javier Andreu, Juan Tascon
BACKGROUND: An increasing number of patients undergoing percutaneous interventions (PI) have experienced previous coronary artery bypass graft surgery (CABG). However, the impact of PI on outcomes in such patients is currently unclear. We evaluated the immediate and 1-year clinical outcomes of post-CABG patients who underwent PI in a tertiary center. METHODS: From January-2005 to September-2006, 91 consecutive post-CABG patients underwent 197 stent implantations (84% drug-eluting stents) for 154 lesions...
May 15, 2009: International Journal of Cardiology
https://www.readbyqxmd.com/read/18274180/off-pump-coronary-artery-grafting-in-patients-necessitating-multiple-distal-anastomoses
#11
J Remes, J P Goldstein, G Vandenplas, P Verleyen, F E Deuvaert
OBJECTIVES: Off-pump surgery has become a valuable alternative if a small number of distal anastomoses is required. The aim of the present study was to test the hypothesis that outcome is not altered in multiple distal anastomoses. MATERIAL AND METHODS: During a 4 year period, 350 patients were operated off-pump. 187 patients received one or two distal anastomoses (group A), and 163 patients received more than two distal anastomoses (group B). Pre-operative characteristics, intra-operative details and postoperative outcome were reviewed...
November 2007: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/18154163/-valuation-of-myocardial-disfunction-of-life-quality-and-survival-value-of-patients-chronic-heart-weakness-in-dependence-of-order-of-constant-electrocardiostimulation
#12
A V Ardashev, V N Ardashev, O V Iakob
No abstract text is available yet for this article.
August 2007: Voenno-medit︠s︡inskiĭ Zhurnal
https://www.readbyqxmd.com/read/18020877/-cross-sectional-study-of-heart-failure-of-patients-intaked-in-an-internal-medicine-service-in-the-third-level-hospital-in-mixed-area-part-iii-mortality-analysis
#13
COMPARATIVE STUDY
S Cinza Sanjurjo, A Cabarcos Ortiz de Barrón, E Nieto Pol, J A Torre Carballada
OBJECTIVES: To establish the characteristics of the deceased in intaked patients by heart failure. MATERIAL AND METHODS: A cross-sectional study of the intaked patients in the Internal Medicine Service in the Hospital Clínico Universitario de Santiago de Compostela between 1999 to 2003. The variables analized were: sex, age, days of hospital stay, number of intaked by failure cardiac, reason for admission (guide symptom), hypertension, diabetes mellitus, cardiac disease, fibrillation atrium, previous treatment with beta-blockers, blood pressure in the admission moment, to make echocardiography, disfunction systolic, etiology, deceased, treatment at the end...
August 2007: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
https://www.readbyqxmd.com/read/17547799/-analysis-of-the-mechanisms-of-thrombosis-after-implantation-of-drug-eluting-stents
#14
RANDOMIZED CONTROLLED TRIAL
Ji-lin Chen, Yue-jin Yang, Shu-bin Qiao, Jing-han Huang, Min Yao, Xue-wen Qin, Bo Xu, Hai-bo Liu, Yong-jian Wu, Run-lin Gao
OBJECTIVE: Stent thrombosis has been regarded as a severe complication of PCI therapy, therefore, analyzing the causes of thrombosis after implantation of drug-eluting stents (DES) is necessary. METHODS: This is a single center study with no limitation of entry criteria for using DES in patients with coronary heart disease (CHD). From Dec. 2001 to Dec. 2005, 3345 consecutive patients underwent implantation with Cypher stents (eluted with sirolimus: 2165 patients, 2362 lesions, 2695 stents) or TAXUS stents (eluted with paclitaxel: 1180 patients, 1453 lesions, 1725 stents) in our hospital...
March 2007: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/17427422/-structural-and-functional-stage-of-the-myocardium-in-different-forms-of-ischemic-heart-disease
#15
V Iu Maslovs'kyĭ, O M Kolesnyk
152 patients with ischemic heart disease aged from 46 to 60 years have been observed. Among these patients, 69 were with stable stenocardia, 32--with unstable stenocardia and 53--in stage related to acute heart attack. Normal geometry of the heart was found in 33% of patients with stable stenocardia, excentric hypertrophy was found in 30% of patients with stable stenocardia. Excentric hypertrophy prevailed in patients with unstable stenocardia and myocardial infarction. Systolic disfunction of the myocardium was found in 72% of patients with stable stenocardia, in 41% of patients with unstable stenocardia and in 43% of patients with myocardial infarction...
December 2006: Likars'ka Sprava
https://www.readbyqxmd.com/read/17304760/-early-risk-predictors-of-sudden-cardiac-death-after-myocardial-infarction-results-of-follow-up-of-881-patients
#16
Branislav Milovanović, Mirjana Krotin, Dejana Vuković, Vesna Bisenić, Tijana Mirjanić, Slavica Nikolić
INTRODUCTION: It has been shown that depolarization disorders, autonomic dysfunction, and systolic dysfunction of the left ventricle are associated with sudden cardiac death after myocardial infarction. OBJECTIVE: The objective of study was to examine the prognostic value of the most important predictors in the first week after myocardial infarction. METHOD: Study included 881 patients who were followed up from 1 to 60 months. During the first week after myocardial infarction, following examination were performed: ECG with standard leads and X, Y, Z orthogonal leads, vectorcardiogram, QT interval, late potentials, short-time spectral analysis of RR variability, nonlinear (Poincaré plot) analysis and echocardiogram...
November 2006: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/16812993/-off-pump-myocardial-revascularization-opcab-in-patients-with-post-infarction-unstabile-angina-low-ejection-fraction-and-renal-disfunction
#17
S Kacar, M Stanić, S Putnik, S Pejkić, L Davidović, M Ristić
UNLABELLED: The purpose of this study is to present our experience in off-pump myocardial revascularization in patients with post-infarction unstable angina, left ventricular low ejection fraction and renal dysfunction. MATERIAL AND METHODS: From January 1998. until march 2002, at the Institute for Cardiovascular Diseases in Clinical Centre of Serbia, we have operated 20 patients with post infarction unstable angina, echocardiographicaly proved low ejection fraction (less than 30%) and renal dysfunction (Serum Creatinin 150 micrograms per liter) using this method...
2005: Acta Chirurgica Iugoslavica
https://www.readbyqxmd.com/read/16113849/-age-and-psychologic-disorders-variables-associated-to-post-infarction-sexual-dysfunction
#18
Luciano Janussi Vacanti, Bruno Caramelli
OBJECTIVE: Data on sexual disfunction (SD) after myocardial infarction (MI) are sketchy, especially in our community and in regard to predictors. Both males and females, with active sexual life and no sexual dysfunction prior to MI were evaluated in order to investigate SD incidence after MI, as well as to identify the possible variables associated. METHODS: Forty-three patients were studied consecutively, through structured questionnaires for SD and psychological disorders (PD) diagnosis...
August 2005: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/16108221/-study-of-mithochondrial-permeability-transition-pore-in-the-development-of-myocardial-and-vascular-contractility-disfunctions
#19
A V Dmytriieva, V F Sahach, A Iu Bohuslavs'kyĭ
In experiments on the isolated myocardial and vascular preparations the role of the mithochondrial permiability transition pore (mPTP) in the development of reperfusion injury was investigated. Co-perfusion of the previously activated myocardial trabecula (MT) and arterial rings (AR) by solution collected during the first 5 min of isolated heart reperfusion, caused a sharp and significant decrease of tonic tension of both isolated preparations. Besides the significant inhibition of the MT and AR reactions after electrical stimulation, modulation of AR reaction by the influence of MT is also registered...
2005: Fiziolohichnyĭ Zhurnal
https://www.readbyqxmd.com/read/15845393/wortmannin-induces-zebrafish-cardia-bifida-through-a-mechanism-independent-of-phosphoinositide-3-kinase-and-myosin-light-chain-kinase
#20
Yuexiang Wang, Tao Zhong, Linxi Qian, Yongxin Dong, Qiu Jiang, Li Tan, Houyan Song
Cardia bifida is an anomaly of the embryonic heart in which the bilateral myocardial rudiments fail to travel to the midline, resulting in the formation of two separate hearts in lateral positions. In zebrafish, eight loci responsible for the cardia bifida phenotype were identified in the large-scale genetic screen. Wortmannin has been reported to be a highly selective inhibitor of phosphoinositide 3-kinase and myosin light chain kinase activity. We provide the first evidence that wortmannin treatment of zebrafish embryos can induce cardia bifida in a dose-dependent manner and that wortmannin alters cardiac development between 6 and 16 h post-fertilization...
May 27, 2005: Biochemical and Biophysical Research Communications
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