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https://www.readbyqxmd.com/read/29126637/association-of-high-level-humidifier-disinfectant-exposure-with-lung-injury-in-preschool-children
#1
Dong-Uk Park, Seung-Hun Ryu, Hyun-Suk Roh, Eun Lee, Hyun-Ju Cho, Jisun Yoon, So-Yeon Lee, Young Ah Cho, Kyung-Hyun Do, Soo-Jong Hong
BACKGROUND: Children aged ≤6years reportedly account for 52% of victims of humidifier disinfectant-associated lung injuries. OBJECTIVES: To evaluate the association of humidifier disinfectants with lung injury risk among children aged ≤6years. METHODS: Patients with humidifier disinfectant-associated lung injuries (n=214) who were clinically evaluated to have a definite (n=108), probable (n=49), or possible (n=57) association with humidifier disinfectants as well as control patients (n=123) with lung injury deemed unlikely to be associated with humidifier disinfectant use were evaluated to determine factors associated with increased risk of humidifier disinfectant-associated lung injury using unconditional multiple logistic regression analysis...
November 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29118937/isolation-differentiation-and-characterization-of-mesenchymal-stem-cells-from-human-bone-marrow
#2
Kaveh Baghaei, Seyed Mohmoud Hashemi, Samaneh Tokhanbigli, Ali Asadi Rad, Hamid Assadzadeh-Aghdaei, Abdolhamid Sharifian, Mohammad Reza Zali
Aim: We describe the minimum requirements and a simplified method for isolation and characterization of mesenchymal stem cells (MSCs) from human bone marrow. Background: MSCs are well known adult stem cells present in many tissues such as adipocytes, chondrocytes, osteoblasts, and neurons. Many isolations and characterization methods have emerged to apply MSCs in the clinical applications, which many of them are expensive and time-consuming. Methods: MSC isolation was carried out from human bone marrow, and cultured in defined medium...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29115070/legislative-issues-in-disclosing-financial-conflicts-of-interest-to-participants-in-biomedical-research-effectiveness-and-methodology
#3
REVIEW
Jae Sun Kim
This research focuses on the analysis regarding disclosure of financial conflicts of interest (FCOI) after Gelsinger v. University of Pennsylvania (Penn). The main legal issue was that the participants did not have enough opportunity to make an autonomous decision about participating in the research because he was not informed about the researchers' and the institution's substantial FCOI. The disclosure system was adopted by the Code of Federal Regulations. Under the regulation, researchers and institutions need to report FCOI over $5,000 to the institution, and the internal review boards have to report to the federal authority if needed...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29107378/the-role-of-the-indoor-environment-residential-determinants-of-allergy-asthma-and-pulmonary-function-in-children-from-a-us-mexico-border-community
#4
Erik R Svendsen, Melissa Gonzales, Adwoa Commodore
The El Paso Children's Health Study examined environmental risk factors for allergy and asthma among fourth and fifth grade schoolchildren living in a major United States-Mexico border city. Complete questionnaire information was available for 5210 children, while adequate pulmonary function data were available for a subset of 1874. Herein we studied indoor environmental health risk factors for allergy and asthma. Several indoor environmental risk factors were associated with allergy and asthma. In particular, we found that ant and spider pest problems, pet dogs, fireplace heat, central air conditioning, humidifier use, and cooking with gas stoves were positively associated with both allergy and asthma prevalence...
October 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29106924/a-randomized-trial-of-conditioned-or-unconditioned-gases-for-stabilizing-preterm-infants-at-birth
#5
Lorraine McGrory, Louise S Owen, Marta Thio, Jennifer A Dawson, Anthony R Rafferty, Atul Malhotra, Peter G Davis, C Omar F Kamlin
OBJECTIVE: To determine whether the use of heated-humidified gases for respiratory support during the stabilization of infants <30 weeks of gestational age (GA) in the delivery room reduces rates of hypothermia on admission to the neonatal intensive care unit (NICU). STUDY DESIGN: A multicenter, unblinded, randomized trial was conducted in Melbourne, Australia, between February 2013 and June 2015. Infants <30 weeks of GA were randomly assigned to receive either heated-humidified gases or unconditioned gases during stabilization in the delivery room and during transport to NICU...
October 26, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29076616/benefits-of-the-humidified-low-flow-oxygen-therapy-in-infants-with-mild-moderate-bronchiolitis
#6
Sonia Lorente, Rebeca Gimeno, Josep Maria Losilla, Sandra Garzón, Jaume Vives
BACKGROUND: There is no evidence to support the use of humidification in low-flow oxygen therapy as a usual clinical practice in the management of bronchiolitis. AIMS AND OBJECTIVES: To investigate the clinical benefits of using humidification in low-flow oxygen therapy. Specific objectives were to investigate via an assessment of the number of nasal lavages whether humidification can help to decrease the nasal mucus viscosity, to determine whether it can relieve feeding difficulties by comparing the weight gain in infants, to ascertain whether it can relieve respiratory distress by assessing the heart and respiratory rates and contribute to improved clinical outcomes, measured by the length of stay and oxygen requirements DESIGN: A controlled quasi-experimental study...
October 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29071321/chemical-surface-exchange-of-oxygen-on-ceo2-%C3%AE-in-an-o2-h2o-atmosphere
#7
Ho-Il Ji, Xin Xu, Sossina M Haile
The chemical surface reaction rate constant controlling the change of oxidation state of undoped ceria, kChem, was measured at 1400 °C in the range of (∼0 ≤ (pH2O/atm) ≤ 0.163(9)) and (10(-3.85) ≤ (pO2/atm) ≤ 10(-2.86)) via the electrical conductivity relaxation method. In humidified atmospheres, kChem is fully described as the sum of kChem,O2 and kChem,H2O, which are, respectively, the rate constants for oxidation by O2 and by H2O alone. Using measurements under appropriately controlled gas conditions, the total rate constant is found to follow the correlation kChem/cm s(-1) = 10(-(1...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29066588/effect-of-high-flow-nasal-cannula-on-expiratory-pressure-and-ventilation-in-infant-pediatric-and-adult-models
#8
Katie R Nielsen, Laura E Ellington, Alan J Gray, Larissa I Stanberry, Lincoln S Smith, Robert M DiBlasi
BACKGROUND: Heated and humidified high-flow nasal cannula (HFNC) is a widely used form of respiratory support; however, data regarding optimal flows for a given patient size or disease state are lacking. A comprehensive study of the physiologic effects of HFNC is needed to better understand the mechanisms of action. The objective of the current study was to quantify the effect of HFNC settings in age-specific, anatomically correct nasal airways and spontaneously breathing lung models...
October 24, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29054517/size-distribution-of-salbutamol-ipratropium-aerosols-produced-by-different-nebulizers-in-the-absence-and-presence-of-heat-and-humidification
#9
Ssu-Han Yang, Tsung-Ming Yang, Hui-Ling Lin, Ying-Huang Tsai, Tien-Pei Fang, Gwo-Hwa Wan
BACKGROUND: Few studies have evaluated the size distribution of inhaled and exhaled aerosolized drugs, or the effect of heated humidification on particle size and lung deposition. The present study evaluated these aspects of bronchodilator (salbutamol/ipratropium) delivery using a lung model in the absence and presence of heat and humidification. METHODS: We positioned filters to collect and measure the initial drug, inhaled drug, and exhaled drug. Particle size distribution was evaluated using an 8-stage Marple personal cascade impactor with 0...
October 17, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29052557/determination-of-volatile-organic-compounds-in-exhaled-breath-of-heart-failure-patients-by-needle-trap-micro-extraction-coupled-with-gas-chromatography-tandem-mass-spectrometry
#10
Denise Biagini, Tommaso Lomonaco, Silvia Ghimenti, Francesca Giuseppa Bellagambi, Massimo Onor, Maria Chiara Scali, Valentina Barletta, Mario Marzilli, Pietro Salvo, Maria Giovanna Trivella, Roger Fuoco, Fabio Di Francesco
The analytical performances of needle trap micro-extraction (NTME) coupled with gas chromatography tandem mass spectrometry were evaluated by analyzing a mixture of twenty-two representative breath VOCs belonging to different chemical classes (i.e. hydrocarbons, ketones, aldehydes, aromatics and sulfurs). NTME is an emerging technique that guarantees detection limits in pptv range by pre-concentrating low volumes of sample, and it is particularly suitable for breath analysis. For most VOCs, detection limits between 20 and 500 pptv were obtained by pre-concentrating 25 mL of a humidified standard gas mixture at a flow rate of 15 mL/min...
October 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29035923/randomized-trial-of-desktop-humidifier-for-dry-eye-relief-in-computer-users
#11
Michael T M Wang, Evon Chan, Linda Ea, Clifford Kam, Yvonne Lu, Stuti L Misra, Jennifer P Craig
SIGNIFICANCE: Dry eye is a frequently reported problem among computer users. Low relative humidity environments are recognized to exacerbate signs and symptoms of dry eye, yet are common in offices of computer operators. Desktop USB-powered humidifiers are available commercially, but their efficacy for dry eye relief has not been established. PURPOSE: This study aims to evaluate the potential for a desktop USB-powered humidifier to improve tear-film parameters, ocular surface characteristics, and subjective comfort of computer users...
November 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29026061/from-specific-humidifier-disinfectants-disease-to-humidifier-disinfectants-syndrome
#12
Jong-Han Leem, Jong-Hyeon Lee
Humidifier disinfectant damage was terrible chemical damage caused by household goods that happened in only South Korea, but it is still very little known in humidifier disinfectant damage. Up to now, previous research tried to focus on interstitial fibrosis on terminal bronchiole and alveoli because it is specific finding, compared with other diseases. To figure out overall effects from HDs, many epidemiologic and toxicologic research is underway. Humidifier disinfectants showed to give rise to typical toxicologic effects on various target organs, such as skin, conjunctiva, naval mucosa, bronchial mucosa, alveoli and so on, which were sharing common toxicological responses...
October 7, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28992790/human-exposure-to-polyhexamethylene-guanidine-phosphate-from-humidifiers-in-residential-settings-cause-of-serious-lung-disease
#13
Ji Hyun Lee, Il Je Yu
Exposure to the humidifier disinfectant, polyhexamethylene guanidine phosphate (PHMG), in mists generated from ultrasonic humidifiers was studied in a simulation chamber and apartment rooms. PHMG is suspected as a causative agent of lung disease in Korea residences. In the simulation-chamber study, the amount of disinfectant discharged from three different ultrasonic humidifiers was measured. Mists generated at 1, 2, and 4 times the recommended amount of disinfectant were sampled with an impinger, and the effect of relative humidity (RH) on airborne disinfectant concentration was studied by changing RH from 60%-70% to 90%-100%...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28990261/heated-air-humidification-versus-cold-air-nebulization-in-newly-tracheostomized-patients
#14
Richard Birk, Alexander Händel, Angela Wenzel, Benedikt Kramer, Christoph Aderhold, Karl Hörmann, Boris A Stuck, J Ulrich Sommer
BACKGROUND: After tracheostomy, the airway lacks an essential mechanism for warming and humidifying the inspired air with the consequent functional impairment and discomfort. The purpose of this study was to compare airway hydration with cold-air nebulization versus heated high-flow humidification on medical interventions and tracheal ciliary beat frequency (CBF). METHODS: Newly tracheostomized patients (n = 20) were treated either with cold-air nebulization or heated humidification...
October 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28985513/increasing-air-humidity-influences-hydraulic-efficiency-but-not-functional-vulnerability-of-xylem-in-hybrid-aspen
#15
Arne Sellin, Meeli Alber, Priit Kupper
Climate models predict greater increases in the frequency than in the amount of precipitation and a consequent rise in atmospheric humidity at high latitudes by the end of the century. We investigated the responses of hydraulic and relevant anatomical traits of xylem to elevated relative humidity of air on a 1-yr-old coppice of hybrid aspen (Populus×wettsteinii) growing in the experimental stand at the Free Air Humidity Manipulation site in Eastern Estonia. The hydraulic conductivity of stems was measured with a high pressure flow meter; artificial cavitation in the stem segments was induced by the air injection method...
September 28, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28977653/to-compare-the-efficacy-of-heated-humidified-high-flow-nasal-cannula-and-continuous-positive-airway-pressure-in-post-extubation-period-in-vlbw-infants
#16
Bhawan Deep Garg, Naveen Bajaj, Deepak Sharma
Objective: The objective of this study was to compare efficacy of continuous positive airway pressure (CPAP) and heated humidified high-flow nasal cannula (HHHFNC) as noninvasive respiratory support in post-extubation period in very low birth weight (VLBW) infants. Method: This retrospective study enrolled 136 neonates, ≤32 weeks gestation and ≤1500 grams birth weight, requiring noninvasive respiratory support during post-extubation period. Results: There was no significant difference in post-extubation failure in HHHFNC group when compared with CPAP group ( p  > 0...
August 8, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28977257/ventilatory-changes-during-the-use-of-heat-and-moisture-exchangers-in-patients-submitted-to-mechanical-ventilation-with-support-pressure-and-adjustments-in-ventilation-parameters-to-compensate-for-these-possible-changes-a-self-controlled-intervention-study
#17
Jeanette Janaina Jaber Lucato, Thiago Marraccini Nogueira da Cunha, Aline Mela Dos Reis, Patricia Salerno de Almeida Picanço, Renata Cléia Claudino Barbosa, Joyce Liberali, Renato Fraga Righetti
OBJECTIVE: To evaluate the possible changes in tidal volume, minute volume and respiratory rate caused by the use of a heat and moisture exchanger in patients receiving pressure support mechanical ventilation and to quantify the variation in pressure support required to compensate for the effect caused by the heat and moisture exchanger. METHODS: Patients under invasive mechanical ventilation in pressure support mode were evaluated using heated humidifiers and heat and moisture exchangers...
April 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28974074/reply-to-transnasal-humidified-rapid-insufflation-ventilatory-exchange-thrive-in-children-a-randomized-controlled-trial
#18
J G McCormack, S Krosnar, A Baxter
No abstract text is available yet for this article.
July 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28972955/impaired-cerebellar-maturation-growth-restriction-and-circulating-insulin-like-growth-factor-1-in-preterm-rabbit-pups
#19
Kristbjörg Sveinsdóttir, John-Kalle Länsberg, Snjólaug Sveinsdóttir, Martin Garwicz, Lennart Ohlsson, Ann Hellström, Lois Smith, Magnus Gram, David Ley
Cerebellar growth is impeded following very preterm birth in human infants and the observed reduction in cerebellar volume is associated with neurodevelopmental impairment. Decreased levels of circulating insulin-like growth factor 1 (IGF-1) are associated with decreased cerebellar volume. The relationship between preterm birth, circulating IGF-1, and key cell populations supporting cerebellar proliferation is unknown. The aim of this study was to evaluate the effect of preterm birth on postnatal growth, circulating IGF-1, and cerebellar maturation in a preterm rabbit pup model...
October 4, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28966735/continuous-positive-airway-pressure-is-it-a-route-for-infection-in-those-with-obstructive-sleep-apnoea
#20
Liam Mercieca, Richard Pullicino, Kyra Camilleri, Rodianne Abela, Sean Apap Mangion, Julian Cassar, Matthew Zammit, Christine Gatt, Christopher Deguara, Christopher Barbara, Peter Fsadni, Stephen Montefort
INTRODUCTION: Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnoea (OSA), with limited data about the prevalence of respiratory infections and microbial colonization in these patients. OBJECTIVES: The aim of this study was to determine if CPAP use is associated with respiratory infections and to identify the organisms that colonize or infect these patients. METHOD: A retrospective, case-controlled study in patients diagnosed with OSA was carried out...
January 2017: Sleep Science
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