keyword
https://read.qxmd.com/read/38530649/iatrogenic-hyperchloremia-an-overview-in-hospitalized-patients-for-pharmacists
#1
JOURNAL ARTICLE
Amoreena Most, Sarah Nordbeck, Nicholas Farina
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: The purpose of this therapeutic update is to provide pharmacists with a general overview of the pathophysiology of hyperchloremia and describe strategies to help prevent development of this electrolyte abnormality in hospitalized patients...
March 26, 2024: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/38530069/adjusting-current-hemoglobin-thresholds-a-way-to-improve-outcome-in-women-undergoing-major-surgery
#2
JOURNAL ARTICLE
Alina Netz, Lotta Hof, Florian Rumpf, Lea Valeska Blum, Vanessa Neef, Anja Kerner, Kai Zacharowski, Patrick Meybohm, Suma Choorapoikayil
Background/Objective: In the perioperative setting, a suboptimal total hemoglobin (Hb) mass puts women and men at an unreasonable disadvantage. Anemia is an independent risk factor for transfusion, postoperative complications, and mortality. The Hb cut-off value for women was set at <12.0 g/dL by the World Health Organization (WHO) and has been rigorously debated for decades. The aim of this study was to elucidate the risk for postoperative complications in female patients with Hb levels < 12...
March 26, 2024: Journal of Women's Health
https://read.qxmd.com/read/38529931/acute-kidney-injury-in-children-with-lymphoma
#3
JOURNAL ARTICLE
Hejia Zhang, Yanlong Duan, Xiaoxue Li, Zhi Chen, Xiaorong Liu
OBJECTIVE: To analyze the epidemiology of acute kidney injury (AKI) in children with lymphoma and to assess the incidence, risk profile of AKI, and effects on renal function in children with lymphoma during their first 30 days of hospitalization. MATERIALS AND METHODS: This was a retrospective screen of electronic hospital and laboratory databases to select hospitalized children who were first diagnosed and treated for lymphoma at Beijing Children's Hospital between 2020 and 2021...
March 26, 2024: Clinical Nephrology
https://read.qxmd.com/read/38529465/a-case-report-of-neuro-beh%C3%A3-et-syndrome-frequent-neurological-manifestations-concurrent-with-life-threatening-illnesses
#4
Omar Ballut, Mayas M Almahi, Banan S Alghamdi, Najla K Alzahrani, Maali A Alghamdi
​​​​Behçet disease (BD) is a recurrent, multisystemic autoimmune vasculitis that affects both small and large vessels. A combination of neurological signs and symptoms in BD is called neuro-Behçet syndrome (NBS). We present the case of a 31-year-old male diagnosed with chronic progressive NBS who presented with multiple relapsing episodes concurrent with infective endocarditis due to intravenous drug abuse, drug-induced hepatitis, acute kidney injury, and septic shock that is not related to BD...
February 2024: Curēus
https://read.qxmd.com/read/38529316/impact-of-covid-status-and-blood-group-on-complications-in-patients-in-hemorrhagic-shock
#5
JOURNAL ARTICLE
Jason Bradley Brill, Krislynn M Mueck, Madeline E Cotton, Brian Tang, Mariela Sandoval, Lillian S Kao, Bryan A Cotton
OBJECTIVE: Among critically injured patients of various blood groups, we sought to compare survival and complication rates between COVID-19-positive and COVID-19-negative cohorts. BACKGROUND: SARS-CoV-2 infections have been shown to cause endothelial injury and dysfunctional coagulation. We hypothesized that, among patients with trauma in hemorrhagic shock, COVID-19-positive status would be associated with increased mortality and inpatient complications. As a secondary hypothesis, we suspected group O patients with COVID-19 would experience fewer complications than non-group O patients with COVID-19...
2024: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/38525759/hemophagocytic-lymphohistiocytosis-hlh-in-patients-with-tick-borne-illness-a-scoping-review-of-98-cases
#6
REVIEW
Dorde Jevtic, Marilia Dagnon da Silva, Alberto Busmail Haylock, Charles W Nordstrom, Stevan Oluic, Nikola Pantic, Milan Nikolajevic, Nikola Nikolajevic, Magdalena Kotseva, Igor Dumic
Hemophagocytic lymphohistiocytosis (HLH) secondary to tick-borne infections is a rare but potentially life-threatening syndrome. We performed a scoping review according to PRISMA guidelines to systematically analyze the existing literature on the topic. A total of 98 patients were included, with a mean age of 43.7 years, of which 64% were men. Most cases, 31%, were reported from the USA. Immunosuppression was present in 21.4%, with the most common cause being previous solid organ transplantation. Constitutional symptoms were the most common, observed in 83...
February 21, 2024: Infectious Disease Reports
https://read.qxmd.com/read/38524515/significant-risk-factors-for-intensive-care-unit-acquired-weakness-a-processing-strategy-based-on-repeated-machine-learning
#7
JOURNAL ARTICLE
Ling Wang, Deng-Yan Long
BACKGROUND: Intensive care unit-acquired weakness (ICU-AW) is a common complication that significantly impacts the patient's recovery process, even leading to adverse outcomes. Currently, there is a lack of effective preventive measures. AIM: To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and treatment. METHODS: Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU admission...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38519599/acute-kidney-injury-in-pediatric-burn-patients
#8
JOURNAL ARTICLE
Demet Kahramanlar, Sare Gülfem Özlü, Pervin Demirci, Elif Emel Erten, Emrah Şenel, Umut Selda Bayrakçi
BACKGROUND: Acute kidney injury (AKI) is a common and important complication of burn injury. Although there are numerous adult studies, data regarding AKI in pediatric burn patients are scarce. Here, we aimed to evaluate the frequency, clinical features, and prognosis of AKI among pediatric burn injury patients. METHODS: This is a retrospective cohort study. Patients aged between 1 month and 18 years who had been followed up between the years 2011 and 2017 were included, and patients with previous kidney disease were excluded...
March 22, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38518195/systemic-inflammation-response-index-as-a-prognostic-factor-for-patients-with-sepsis-associated-acute-kidney-injury-a-retrospective-observational-study
#9
JOURNAL ARTICLE
Jia Tang, Zhenguang Zhong, Muyesai Nijiati, Changdong Wu
OBJECTIVE: To assess the association between the systemic inflammation response index (SIRI) and the prognosis in patients with sepsis-associated acute kidney injury (SA-AKI). METHODS: In this observational study, adult patients with SA-AKI were categorized into three groups based on SIRI tertiles. Survival outcomes were compared across the three groups using Kaplan-Meier survival curves. Various Cox proportional hazards regression models were developed to determine the association between the SIRI and mortality in patients with SA-AKI...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38517565/wtap-mediated-n6-methyladenosine-modification-promotes-the-inflammation-mitochondrial-damage-and-ferroptosis-of-kidney-tubular-epithelial-cells-in-acute-kidney-injury-by-regulating-lmnb1-expression-and-activating-nf-%C3%AE%C2%BAb-and-jak2-stat3-pathways
#10
JOURNAL ARTICLE
Fan Huang, Yuchen Wang, XiaoLi Lv, Chenda Huang
Acute kidney injury (AKI) is a serious complication of sepsis patients, but the pathogenic mechanisms underlying AKI are still largely unclear. In this view, the roles of the key component of N6-methyladenosine (m6A)-wilms tumor 1 associated protein (WTAP) in AKI progression were investigated. AKI mice model was established by using cecal ligation and puncture (CLP). AKI cell model was established by treating HK-2 cells with LPS. Cell apoptosis was analyzed by TdT-mediated dUTP Nick-End Labeling (TUNEL) staining and flow cytometry analysis...
March 22, 2024: Journal of Bioenergetics and Biomembranes
https://read.qxmd.com/read/38516467/mortality-analysis-in-geriatric-patients-with-acute-kidney-injury-admitted-in-the-intensive-care-unit-a-single-center-cross-sectional-study
#11
JOURNAL ARTICLE
Girish V Kumthekar, Veena Purandare, Manasi Nagarkar, Shruti Paramshetti
Introduction Acute kidney injury (AKI) is an abrupt reduction in kidney function that causes nitrogenous waste and other waste products to be retained. Methods This cross-sectional study was conducted from February 2015 to January 2016. The study received approval from the Independent Ethics Committee, which included patients over 60 with AKI. The study duration was 12 consecutive months to ascertain the etiology, severity, and hospital outcomes of AKI. Results The common etiologies of AKI included drug-induced (25%), age-related (21...
February 2024: Curēus
https://read.qxmd.com/read/38515158/acetyl-coa-synthetase-2-induces-pyroptosis-and-inflammation-of-renal-epithelial-tubular-cells-in-sepsis-induced-acute-kidney-injury-by-upregulating-the-klf5-nf-%C3%AE%C2%BAb-pathway
#12
JOURNAL ARTICLE
Jian Lu, Ya Hou, Si-Xiu Liu, Bo Jin, Jing Liu, Nan Li, Yan Zhu, Qing-Yan Zhang, Cheng Wan, Yuan Feng, Jun Xie, Chun-Ming Jiang
BACKGROUND: Pyroptosis of the renal tubular epithelial cells (RTECs) and interstitial inflammation are central pathological characteristics of acute kidney injury (AKI). Pyroptosis acts as a pro-inflammatory form of programmed cell death and is mainly dependent on activation of the NLRP3 inflammasome. Previous studies revealed that acetyl-CoA synthetase 2 (ACSS2) promotes inflammation during metabolic stress suggesting that ACSS2 might regulate pyroptosis and inflammatory responses of RTECs in AKI...
March 21, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38515121/sepsis-associated-acute-kidney-injury-recent-advances-in-enrichment-strategies-sub-phenotyping-and-clinical-trials
#13
REVIEW
Matthieu Legrand, Sean M Bagshaw, Pavan K Bhatraju, Azra Bihorac, Ellen Caniglia, Ashish K Khanna, John A Kellum, Jay Koyner, Michael O Harhay, Fernando G Zampieri, Alexander Zarbock, Kevin Chung, Kathleen Liu, Ravindra Mehta, Peter Pickkers, Abigail Ryan, Juliane Bernholz, Laura Dember, Martin Gallagher, Patrick Rossignol, Marlies Ostermann
Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and mortality. In recent years, several important clinical trials have improved our understanding of sepsis-associated AKI (SA-AKI) and impacted clinical care. Advances in sub-phenotyping of sepsis and AKI and clinical trial design offer unprecedented opportunities to fill gaps in knowledge and generate better evidence for improving the outcome of critically ill patients with SA-AKI. In this manuscript, we review the recent literature of clinical trials in sepsis with focus on studies that explore SA-AKI as a primary or secondary outcome...
March 21, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38513598/dexmedetomidine-attenuates-lipopolysaccharide-induced-renal-cell-fibrotic-phenotypic-changes-by-inhibiting-necroinflammation-via-activating-%C3%AE-2-adrenoceptor-a-combined-randomised-animal-and-in-vitro-study
#14
JOURNAL ARTICLE
Qizhe Sun, Priyanka Kamath, Yibing Sun, Min Liang, Lingzhi Wu, Enqiang Chang, Qian Chen, Azeem Alam, Yi Liu, Hailin Zhao, Daqing Ma
BACKGROUND: Acute kidney injury (AKI) was reported to be one of the initiators of chronic kidney disease (CKD) development. Necroinflammation may contribute to the progression from AKI to CKD. Dexmedetomidine (Dex), a highly selective α2 -adrenoreceptor (AR) agonist, has cytoprotective and "anti-" inflammation effects. This study was designed to investigate the anti-fibrotic properties of Dex in sepsis models. METHODS: C57BL/6 mice were randomly treated with an i...
March 19, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38510775/the-use-of-sustained-low-efficiency-dialysis-in-the-treatment-of-sepsis-associated-acute-kidney-injury-in-a-low-income-country-a-prospective-cohort-study
#15
JOURNAL ARTICLE
Abdalla Kamal Abdalla Taha, Mazin Mohammed Taha Shigidi, Nazik Mahmoud Abdulfatah, Rajabia Khidir Alsayed
BACKGROUND: Limited data are available regarding the management and outcomes of patients with sepsis-associated acute kidney injury (SA-AKI) requiring dialysis in Sudan. Continuous renal replacement therapy (CRRT) is a highly favored treatment modality in such patients. However, it stays unavailable and expensive treatment in most low-income countries. We aimed to evaluate the use of sustained low-efficiency dialysis (SLED) in the treatment of hemodynamically unstable patients with SA-AKI admitted to the intensive care unit (ICU)...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510768/is-sled-efficient-in-sepsis-associated-acute-kidney-injury-hope-but-hold
#16
EDITORIAL
Akshaykumar Amarchand Chhallani
How to cite this article: Chhallani AA. Is SLED Efficient in Sepsis Associated Acute Kidney Injury: Hope but Hold!! Indian J Crit Care Med 2024;28(1):5-7.
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38505156/the-challenging-management-of-malignant-ureteral-obstruction-analysis-of-a-series-of-188-cases
#17
JOURNAL ARTICLE
Alberto Artiles Medina, Inés Laso García, Fernando González Tello, Sara Álvarez Rodríguez, Manuel Hevia Palacios, Marina Mata Alcaraz, César Mínguez Ojeda, Fernando Arias Funez, Victoria Gómez Dos Santos, Francisco Javier Burgos Revilla
BACKGROUND: Malignant ureteral obstruction (MUO) is a common condition that complicates the course of advanced malignancies. The aims of this study are to analyze the causes, management, and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic factors. Furthermore, we studied the complications and outcomes in patients who underwent urinary diversion. MATERIALS AND METHODS: A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November 2020...
March 2024: Current Urology
https://read.qxmd.com/read/38502459/autologous-cell-salvage-in-off-pump-coronary-artery-bypass-surgery-reduces-post-operative-complications-a-retrospective-weighted-matching-analysis
#18
JOURNAL ARTICLE
Amber Malhotra, Md Anamul Islam, Giuseppe Tavilla, Nikki E Williams, Thomas d'Amato
OBJECTIVES: Blood transfusion plays a crucial role in coronary artery bypass grafting (CABG). The choice between autologous cell saver (CS) and allogenic blood transfusion (ABT) has been a continuous debate in the medical community, especially within cardiac surgery. This study aimed to assess the outcomes of off-pump CABG (OPCAB) surgery in patients receiving blood solely via cell salvage compared to those receiving ABT or a combination of ABT and CS perioperatively. METHODS: A total of 414 patients who underwent isolated OPCAB surgery at our cardiovascular clinic were analyzed...
March 19, 2024: General Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38501417/-chlorogenic-acid-alleviates-acute-kidney-injury-in-septic-mice-by-inhibiting-nlrp3-inflammasomes-and-the-caspase-1-canonical-pyroptosis-pathway
#19
JOURNAL ARTICLE
S Fang, R Sun, H Su, K Zhai, Y Xiang, Y Gao, W Guo
OBJECTIVE: To investigate the role of caspase-1-medicated canonical pyroptosis pathway in chlorogenic acid (CGA) treatment of acute kidney injury (AKI) in mice. METHOD: Twenty-four C57Bl/6J mice were randomized into sham-operated group, cecal ligation and puncture (CLP) group, CLP+dexamethasone group (CLP+DXM group), and CLP+CGA group ( n =6) and subjected to either sham operation (laparotomy only) or CLP. After modeling the mice received intravenous infusion of 10 mg/kg normal saline (in sham and CLP groups), 1 μg/kg dexamethasone or 15 mg/kg of chlorogenic acid for 6 h delivered using an intravenous pump...
February 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/38497110/timp2-protects-against-sepsis-associated-acute-kidney-injury-by-camp-nlrp3-axis-mediated-pyroptosis
#20
JOURNAL ARTICLE
Dongxue Xu, Jun Jiang, Ye Liu, Jingjing Pang, Jinmeng Suo, Yiming Li, Zhiyong Peng
The tissue inhibitor of metalloproteinases 2 (TIMP2) has emerged as a promising biomarker for predicting the risk of sepsis-associated acute kidney injury (SA-AKI). However, its exact role in SA-AKI and the underlying mechanism remains unclear. In this study, we investigated the impact of kidney tubule-specific Timp2 knockout mice on kidney injury and inflammation. Our findings demonstrated that Timp2-knockout mice exhibited more severe kidney injury than wild-type mice, along with elevated levels of pyroptosis markers NLRP3, Caspase1, and GSDMD in the early stage of SA-AKI...
March 18, 2024: American Journal of Physiology. Cell Physiology
keyword
keyword
116479
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.