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Citral

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https://www.readbyqxmd.com/read/29450147/lemongrass-cymbopogon-flexuosus-essential-oil-demonstrated-anti-inflammatory-effect-in-pre-inflamed-human-dermal-fibroblasts
#1
Xuesheng Han, Tory L Parker
Lemongrass ( Cymbopogon flexuosus ) essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF)...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29433490/citral-induced-apoptosis-in-mda-mb-231-spheroid-cells
#2
Siyamak Ebrahimi Nigjeh, Swee Keong Yeap, Norshariza Nordin, Behnam Kamalideghan, Huynh Ky, Rozita Rosli
BACKGROUND: Breast cancer remains a leading cause of death in women worldwide. Although breast cancer therapies have greatly advanced in recent years, many patients still develop tumour recurrence and metastasis, and eventually succumb to the disease due to chemoresistance. Citral has been reported to show cytotoxic effect on various cancer cell lines. However, the potential of citral to specifically target the drug resistant breast cancer cells has not yet been tested, which was the focus of our current study...
February 13, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29421354/risk-management-of-ochratoxigenic-fungi-and-ochratoxin-a-in-maize-grains-by-bioactive-evoh-films-containing-individual-components-of-some-essential-oils
#3
Andrea Tarazona, José V Gómez, Rafael Gavara, Rufino Mateo-Castro, José V Gimeno-Adelantado, Misericordia Jiménez, Eva M Mateo
Aspergillus steynii and Aspergillus tubingensis are possibly the main ochratoxin A (OTA) producing species in Aspergillus section Circumdati and section Nigri, respectively. OTA is a potent nephrotoxic, teratogenic, embryotoxic, genotoxic, neurotoxic, carcinogenic and immunosuppressive compound being cereals the first source of OTA in the diet. In this study bioactive ethylene-vinyl alcohol copolymer (EVOH) films containing cinnamaldehyde (CINHO), linalool (LIN), isoeugenol (IEG) or citral (CIT) which are major components of some plant essential oils (EOs) were produced and tested against A...
February 3, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29394873/composition-of-essential-oil-of-lemon-thyme-thymus-%C3%A3-citriodorus-at-different-hydrodistillation-times
#4
Rūta Jurevičiūtė, Kristina Ložienė, Maurizio Bruno, Antonella Maggio, Sergio Rosselli
Distillation time can both to optimise the production and to engineer the composition of essential oil in essential oil bearing plants. Purpose of this study was to evaluate the effect of duration of hydrodistillation on composition of essential oil of Thymus × citriodorus, the natural source of commercially important geraniol and citral, a component with valuable biological properties. Essential oils were isolated by hydrodistillation at different distillation times and analysed by GC/MS analytical methods...
February 2, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29389592/preparation-characterization-and-antimicrobial-activity-of-nanoemulsions-incorporating-citral-essential-oil
#5
Wen-Chien Lu, Da-Wei Huang, Chiun-C R Wang, Ching-Hua Yeh, Jen-Chieh Tsai, Yu-Ting Huang, Po-Hsien Li
Citral is a typical essential oil used in the food, cosmetic, and drug industries and has shown antimicrobial activity against microorganisms. Citral is unstable and hydrophobic under normal storage conditions, so it can easily lose its bactericide activity. Nanoemulsion technology is an excellent way to hydrophilize, microencapsulate, and protect this compound. In our studies, we used a mixed surfactant to form citral-in-water nanoemulsions, and attempted to optimize the formula for preparing nanoemulsions...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29389585/effects-of-lemongrass-oil-and-citral-on-hepatic-drug-metabolizing-enzymes-oxidative-stress-and-acetaminophen-toxicity-in-rats
#6
Chien-Chun Li, Hsiang-Fu Yu, Chun-Hua Chang, Yun-Ta Liu, Hsien-Tsung Yao
The essential oil from a lemongrass variety of Cymbopogon flexuosus [lemongrass oil (LO)] is used in various food and aroma industry products and exhibits biological activities, such as anticancer and antimicrobial activities. To investigate the effects of 200 LO (200 mg/kg) and 400 LO (400 mg/kg) and its major component, citral (240 mg/kg), on drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in the liver, male Sprague-Dawley rats were fed a pelleted diet and administered LO or citral by gavage for 2 weeks...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29374037/whole-genome-sequencing-and-genetic-analysis-reveals-novel-stress-responses-against-individual-constituents-of-essential-oils-in-escherichia-coli
#7
Beatriz Chueca, Adriana Renzoni, Daniel Berdejo, Rafael Pagán, William L Kelley, Diego García-Gonzalo
Food preservation by the use of essential oils (EOs) is being extensively studied, because of the antimicrobial properties of their individual constituents (ICs). Three resistant mutants (termed CAR, CIT and LIM) of Escherichia coli MG1655 were selected by subculturing with the ICs carvacrol, citral and (+)-limonene oxide, respectively. These derivative strains showed increased MIC values to ICs and concomitant enhanced resistance to various antibiotics (ampicillin, trimethoprim, chloramphenicol, tetracycline, kanamycin, novobiocin, norfloxacin, cephalexin and nalidixic acid) compared with the parental strain (WT)...
January 26, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29329873/preparation-and-characterization-of-citral-loaded-solid-lipid-nanoparticles
#8
Huaixiang Tian, Zhuoyan Lu, Danfeng Li, Jing Hu
Citral-loaded solid lipid nanoparticles (citral-SLNs) were prepared via a high-pressure homogenization method, using glyceryl monostearate (GMS) as the solid lipid and a mixture of Tween 80 (T-80) and Span 80 (S-80) at a weight ratio of 1:1 as the surfactant. The microstructure and properties of the citral-SLNs were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermal gravimetric analysis (TGA)...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329229/chemical-composition-and-evaluation-of-the-biological-properties-of-the-essential-oil-of-the-dietary-phytochemical-lippia-citriodora
#9
Eleni Fitsiou, Gregoria Mitropoulou, Katerina Spyridopoulou, Manolis Vamvakias, Haido Bardouki, Alex Galanis, Katerina Chlichlia, Yiannis Kourkoutas, Mihalis Ι Panayiotidis, Aglaia Pappa
The aim of the study was to characterize the chemical composition and biological properties of the essential oil from the plant Lippia citriodora grown in Greece. The essential oil volatiles were analyzed by gas chromatography-mass spectrometry GC-MS indicating citral as the major component. Τhe antimicrobial properties were assayed using the disk diffusion method and the minimum inhibitory and non-inhibitory concentration values were determined. Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus, Saccharomyces cerevisiae, and Aspergillus niger were sensitive to Lippia citriodora oil, but not Escherichia coli, Salmonella Enteritidis, Salmonella typhimurium, and Pseudomonas fragi...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29312812/characterization-and-toxicity-of-citral-incorporated-with-nanostructured-lipid-carrier
#10
Noraini Nordin, Swee Keong Yeap, Nur Rizi Zamberi, Nadiah Abu, Nurul Elyani Mohamad, Heshu Sulaiman Rahman, Chee Wun How, Mas Jaffri Masarudin, Rasedee Abdullah, Noorjahan Banu Alitheen
The nanoparticle as a cancer drug delivery vehicle is rapidly under investigation due to its promising applicability as a novel drug delivery system for anticancer agents. This study describes the development, characterization and toxicity studies of a nanostructured lipid carrier (NLC) system for citral. Citral was loaded into the NLC using high pressure homogenization methods. The characterizations of NLC-citral were then determined through various methods. Based on Transmission Electron Microscope (TEM) analysis, NLC-Citral showed a spherical shape with an average diameter size of 54...
2018: PeerJ
https://www.readbyqxmd.com/read/29304481/structural-and-kinetic-studies-of-a-novel-nerol-dehydrogenase-from-persicaria-minor-a-nerol-specific-enzyme-for-citral-biosynthesis
#11
Cheng Seng Tan, Maizom Hassan, Zeti Azura Mohamed Hussein, Ismanizan Ismail, Kok Lian Ho, Chyan Leong Ng, Zamri Zainal
Geraniol degradation pathway has long been elucidated in microorganisms through bioconversion studies, yet weakly characterised in plants; enzyme with specific nerol-oxidising activity has not been reported. A novel cDNA encodes nerol dehydrogenase (PmNeDH) was isolated from Persicaria minor. The recombinant PmNeDH (rPmNeDH) is a homodimeric enzyme that belongs to MDR (medium-chain dehydrogenases/reductases) superfamily that catalyses the first oxidative step of geraniol degradation pathway in citral biosynthesis...
December 26, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29248831/essential-oil-of-cymbopogon-citratus-lemongrass-and-geraniol-but-not-citral-promote-gastric-healing-activity-in-mice
#12
Larissa Venzon, Luísa Nathália Bolda Mariano, Lincon Bordignon Somensi, Thaise Boeing, Priscila de Souza, Theodoro Marcel Wagner, Sérgio Faloni de Andrade, Luciane Angela Nottar Nesello, Luísa Mota da Silva
Cymbopogon citratus, popularly known as lemongrass, is used for the treatment of gastric, nervous and hypertensive disorders, in addition to its use in the food and pharmaceutical industries. This study evaluated the gastroprotective and gastric healing effect of essential oil of C. citratus (EOCC), citral and geraniol at doses of 1-100 mg/kg (p.o) on acute ethanol-induced ulcer and chronic acetic acid-induced ulcer. Histological and histochemical evaluation was also performed, as well as the in vitro evaluation of the effects of these phytochemicals on H+/K+-ATPase activity...
December 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29234423/antifungal-activity-of-essential-oils-against-candida-albicans-strains-isolated-from-users-of-dental-prostheses
#13
Julliana Cariry Palhano Freire, José Klidenberg de Oliveira Júnior, Daniele de Figueredo Silva, Janiere Pereira de Sousa, Felipe Queiroga Sarmento Guerra, Edeltrudes de Oliveira Lima
Objective: The objective of this study was to analyze the antifungal activity of citral, selected by screening natural products, against Candida albicans isolates from subjects who use dental prostheses. Methodology: Screening of essential oils, including those from Mentha piperita L. (Briq), Origanum vulgare, and Zingiber officinale L., and the phytoconstituents citral and limonene, to select an appropriate natural product. Citral, which mediated the best antifungal response, was selected for biological assays...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29197060/repellency-potential-of-essential-oils-against-housefly-musca-domestica-l
#14
Nitin Chauhan, Anushree Malik, Satyawati Sharma
In present study, the essential oils such as Mentha piperita (mentha oil, M.O), Cymbopogan citratus (lemongrass oil, LG.O), Citrus sinensis (orange oil, O.O), and Eucalyptus globulus (eucalyptus oil, E.O) were evaluated for repellency against housefly (Musca domestica) in a specially designed chamber. Further, to study any synergistic effect, essential oil combinations, i.e., M.O + LG.O, M.O + O.O, and M.O + E.O, were screened at 50:50 and 70:30 ratios. The results showed superior repellency of mentha and mentha + lemongrass (70:30) with RC95 value of 0...
December 2, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29163441/antifungal-and-anti-biofilm-activity-of-essential-oil-active-components-against-cryptococcus-neoformans-and-cryptococcus-laurentii
#15
Poonam Kumari, Rutusmita Mishra, Neha Arora, Apurva Chatrath, Rashmi Gangwar, Partha Roy, Ramasare Prasad
Cryptococcosis is an emerging and recalcitrant systemic infection occurring in immunocompromised patients. This invasive fungal infection is difficult to treat due to the ability of Cryptococcus neoformans and Cryptococcus laurentii to form biofilms resistant to standard antifungal treatment. The toxicity concern of these drugs has stimulated the search for natural therapeutic alternatives. Essential oil and their active components (EO-ACs) have shown to possess the variety of biological and pharmacological properties...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29155200/recent-advances-on-polysaccharides-lipids-and-protein-based-edible-films-and-coatings-a-review
#16
REVIEW
Bilal Hassan, Shahzad Ali Shahid Chatha, Abdullah Ijaz Hussain, Khalid Mahmood Zia, Naseem Akhtar
Food is a vital product for the survival of human beings and with passage of time quality concerns of consumers are rising. Edible films and coatings are thin layers applied on food products to protect them and improve their quality. Films/coatings are prepared from naturally occurring renewable sources (polysaccharides, proteins, lipids and composites) which we can eat without disposing them. These films are environment friendly and contain antioxidants, anti-browning agents and colorants. Various methods (spraying, brushing, electro-spraying) are used to apply a coating on food material to protect them from microbial growth, prolonging their shelf life and improving other quality aspects like sensory attributes, appearance, originality and freshness of ingredients...
November 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29116300/cymbopogon-citratus-essential-oil-effect-on-polymicrobial-caries-related-biofilm-with-low-cytotoxicity
#17
Maria Alcionéia Carvalho de Oliveira, Aline Chiodi Borges, Fernanda Lourenção Brighenti, Marcos José Salvador, Aline Vidal Lacerda Gontijo, Cristiane Yumi Koga-Ito
The objective of this study was to evaluate the effects of Cymbopogon citratus essential oil and its main compound (citral) against primary dental colonizers and caries-related species. Chemical characterization of the essential oil was performed by gas chromatography/mass spectroscopy (GC/MS), and the main compound was determined. Antimicrobial activity was tested against Actinomyces naeslundii, Lactobacillus acidophilus, S. gordonii, S. mitis, S. mutans, S. sanguinis and S. sobrinus. Minimum inhibitory and bactericide concentrations were determined by broth microdilution assay for streptococci and lactobacilli reference, and for clinical strains...
November 6, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29079437/investigation-of-molecular-mechanism-of-recognition-between-citral-and-mark4-a-newer-therapeutic-approach-to-attenuate-cancer-cell-progression
#18
Farha Naz, Faez Iqbal Khan, Taj Mohammad, Parvez Khan, Saaliqa Manzoor, Gulam Mustafa Hasan, Kevin A Lobb, Suaib Luqman, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassan
Microtubule affinity regulating kinase 4 (MARK4) is a member of AMP-activated protein kinase, found to be involved in apoptosis, inflammation and many other regulatory pathways. Since, its aberrant expression is directly associated with the cell cycle and thus cancer. Therefore, MARK4 is being considered as a potential drug target for cancer therapy. Here, we investigated the mechanism of inhibition of MARK4 activity by citral. Docking studies suggested that citral effectively binds to the active site cavity, and complex is stabilized by several interactions...
October 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29078261/antiproliferative-and-apoptosis-inducing-effects-of-citral-via-p53-and-ros-induced-mitochondrial-mediated-apoptosis-in-human-colorectal-hct116-and-ht29-cell-lines
#19
Bassem Y Sheikh, Md Moklesur Rahman Sarker, Muhamad Noor Alfarizal Kamarudin, Gokula Mohan
Despite various anticancer reports, antiproliferative and apoptosis inducing activity of citral in HCT116 and HT29 cells have never been reported. This study aimed to evaluate the cytotoxic and apoptosis inducing effects of citral in colorectal cancer cell lines. The citral-treated cells were subjected to MTT assay followed by flow cytometric Annexin V-FITC/PI, mitochondrial membrane potential and intracellular reactive oxygen species (ROS) determination. The apoptotic proteins expression was investigated by Western blot analysis...
October 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29072326/antimicrobial-activity-of-suspensions-and-nanoemulsions-of-citral-in-combination-with-heat-or-pulsed-electric-fields
#20
E Pagán, D Berdejo, L Espina, D García-Gonzalo, R Pagán
The application of essential oils in form of nanoemulsions has been proposed as a method to improve their solubility in aqueous solutions, and hence their antimicrobial activity. The objective of this study was to evaluate the antimicrobial activity of citral, applied directly or in combined treatments with heat or pulsed electric fields (PEF), as a function of the inoculation procedure assayed: (i) a simple, vigorous shaking method by vortex agitation (suspension of citral; s-citral) or (ii) the previous preparation of nanoemulsions by the emulsion phase inversion (EPI) method (nanoemulsion of citral; n-citral)...
October 26, 2017: Letters in Applied Microbiology
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