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Citral

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https://www.readbyqxmd.com/read/28717379/hepatoprotective-effect-of-citral-on-acetaminophen-induced-liver-toxicity-in-mice
#1
Nancy Sayuri Uchida, Saulo Euclides Silva-Filho, Gabriel Fernando Esteves Cardia, Edivaldo Cremer, Francielli Maria de Souza Silva-Comar, Expedito Leite Silva, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman
High doses of acetaminophen (APAP) lead to acute liver damage. In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP. The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) were determined to evaluate the hepatoprotective effects of citral. The livers were used to determine myeloperoxidase (MPO) activity and nitric oxide (NO) production and in histological analysis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28708833/proliferating-effect-of-radiolytically-depolymerized-carrageenan-on-physiological-attributes-plant-water-relation-parameters-essential-oil-production-and-active-constituents-of-cymbopogon-flexuosus-steud-under-drought-stress
#2
Minu Singh, M Masroor A Khan, Moin Uddin, M Naeem, M Irfan Qureshi
Carrageenan has been proved as potent growth promoting substance in its depolymerized form. However, relatively little is known about its role in counteracting the adverse effects of drought stress on plants. In a pot experiment, lemongrass (Cymbopogon flexuosus Steud.), grown under different water stress regimes [(100% field capacity (FC), 80% FC and 60% FC)], was sprayed with 40, 80 and 120 mg L-1 of gamma irradiated carrageenan (ICA). Foliar application of ICA mitigated the harmful effects of drought stress to various extents and improved the biochemical characteristics, quality attributes and active constituents (citral and geraniol) of lemongrass significantly...
2017: PloS One
https://www.readbyqxmd.com/read/28699786/inactivation-of-norovirus-by-lemongrass-essential-oil-using-a-norovirus-surrogate-system
#3
Ye Won Kim, Hyun Ju You, Soyoung Lee, Bomi Kim, Do Kyung Kim, Joo-Bong Choi, Ji-Ah Kim, Hee Jung Lee, In Sun Joo, Jeong Su Lee, Dong Hyun Kang, Giljae Lee, Gwang Pyo Ko, Sung-Joon Lee
This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay...
July 12, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28685882/simultaneous-patch-testing-with-fragrance-mix-i-fragrance-mix-ii-and-their-ingredients-in-southern-sweden-between-2009-and-2015
#4
Martin Mowitz, Cecilia Svedman, Erik Zimerson, Marléne Isaksson, Ann Pontén, Magnus Bruze
BACKGROUND: Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy. OBJECTIVES: To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients. MATERIALS AND METHODS: A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. RESULTS: Of the patients, 6...
July 7, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28669187/the-discovery-of-citral-like-thiophenes-in-fried-chicken
#5
Robert J Cannon, Nicole L Curto, Cynthia M Esposito, Richard K Payne, Adam J Janczuk, David O Agyemang, Tingwei Cai, Xiao-Qing Tang, Michael Z Chen
The isomers of 3,7-dimethyl-2,6-octadienal, more commonly known together as citral, are two of the most notable natural compounds in the flavor and fragrance industry. However, both isomers are inherently unstable, limiting their potential use in various applications. To identify molecules in nature that can impart the fresh lemon character of citral while demonstrating stability under acidic and thermal conditions has been a major challenge and goal for the flavor and fragrance industry. In the study of fried chicken, several alkyl thiophenecarbaldehydes were identified by gas chromatography-mass spectrometry and gas chromatography-olfactometry that provided a similar citral-like aroma...
July 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28667503/antipyretic-effects-of-citral-and-possible-mechanisms-of-action
#6
Maycon T Emílio-Silva, Clarissa M D Mota, Clélia A Hiruma-Lima, José Antunes-Rodrigues, Evelin C Cárnio, Luiz G S Branco
Citral is a mixture of the two monoterpenoid isomers (neral and geranial) widely used as a health-promoting food additive safe for human and animal (approved by the US Food and Drug Administration). In vitro studies have reported on the capability of citral to reduce inflammation. Here, we report antipyretic effects of citral in vivo using the most well-accepted model of sickness syndrome, i.e., systemic administration of lipopolysaccharide ( LPS ) to rats. Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1β, IL-6, and TNF-α) release, and prostaglandin E2 (PGE2) synthesis (both peripherally and hypothalamic)]...
June 30, 2017: Inflammation
https://www.readbyqxmd.com/read/28663695/in-vitro-evaluation-of-the-effects-of-some-plant-essential-oils-on-ascosphaera-apis-the-causative-agent-of-chalkbrood-disease
#7
Mohammad Javed Ansari, Ahmad Al-Ghamdi, Salma Usmani, Khalid Ali Khan, Abdulaziz S Alqarni, Manpreet Kaur, Noori Al-Waili
Ascosphaera apis is one of the major fungal pathogens of honey bee broods and the causative agent of Chalkbrood disease. The factors responsible for the pathogenesis of Chalkbrood disease are still not fully understood, and the increasing resistance of A. apis to commonly used antifungal agents necessitates a search for new agents to control this disease. The in vitro antifungal activities of 27 plant essential oils against two isolates of A. apis (Aksu-4 and Aksu-9) were evaluated. Out of the 27 plant essential oils tested, 21 were found to be effective in killing both isolates of A...
July 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28644990/global-transcriptional-response-of-escherichia-coli-mg1655-cells-exposed-to-the-oxygenated-monoterpenes-citral-and-carvacrol
#8
Beatriz Chueca, Elisa Pérez-Sáez, Rafael Pagán, Diego García-Gonzalo
DNA microarrays were used to study the mechanism of bacterial inactivation by carvacrol and citral. After 10-min treatments of Escherichia coli MG1655 cells with 100 and 50ppm of carvacrol and citral, 76 and 156 genes demonstrated significant transcriptional differences (p≤0.05), respectively. Among the up-regulated genes after carvacrol treatment, we found gene coding for multidrug efflux pumps (acrA, mdtM), genes related to phage shock response (pspA, pspB, pspC, pspD, pspF and pspG), biosynthesis of arginine (argC, argG, artJ), and purine nucleotides (purC, purM)...
June 20, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28621584/inactivation-of-nondesiccated-and-desiccated-cronobacter-sakazakii-in-reconstituted-infant-formula-by-combination-of-citral-and-mild-heat
#9
Chao Shi, Zhenyu Jia, Yi Sun, Yifei Chen, Du Guo, Zhiyuan Liu, Qiwu Wen, Xiao Guo, Linlin Ma, Baowei Yang, Allah Bux Baloch, Xiaodong Xia
The objective of this study was to evaluate the combined effect of citral plus mild heat on nondesiccated and desiccated Cronobacter sakazakii in reconstituted infant formula. Various concentrations of citral (0, 0.3, 0.6, and 0.9%) combined with various temperatures (25, 45, 50, and 55°C) were applied to nondesiccated and desiccated cocktails of three C. sakazakii strains (approximately 6.0 log CFU mL(-1)) in reconstituted infant formula, and the bacterial populations were assayed periodically. The combined treatments had marked antimicrobial effects on C...
June 16, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28572945/packaging-methods-and-storage-duration-affect-essential-oil-content-and-composition-of-lemon-verbena-lippia-citriodora-kunth
#10
Mohammad-Taghi Ebadi, Fatemeh Sefidkon, Majid Azizi, Noorollah Ahmadi
Changes in essential oils (EOs) content and composition of lemon verbena leave at different packaging methods (packaged with air, nitrogen, or under vacuum) and during storage period (0, 2, 4, 6 and 8 months) were determined. All the samples were hydrodistilled every 2 months during storage for EO content evaluation. EO composition was determined by gas chromatography and gas chromatography-mass spectrometry. The results showed that by extending the storage period in all packaging methods, EO content was significantly decreased...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28522004/development-of-biocompatible-glycodynameric-hydrogels-joining-two-natural-motifs-by-dynamic-constitutional-chemistry
#11
Luminita Marin, Daniela Ailincai, Simona Morariu, Liliana Tartau-Mititelu
The paper focusses on the synthesis of novel hydrogels by joining natural biodegradable compounds with the aim to achieve biocompatible materials for bio related applications. The hydrogels were prepared from chitosan and citral by constitutional dynamic chemistry, incorporating both molecular and supramolecular dynamic features. The hydrophobic flexible citral has been reversible immobilized onto the hydrophilic chitosan backbone via imine bonds to form amphiphilic glycodynamers, which further self-ordered through supramolecular interactions into a 3D-network of biodynameric hydrogel...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28490124/explaining-the-antioxidant-activity-of-some-common-non-phenolic-components-of-essential-oils
#12
Andrea Baschieri, Majlinda Daci Ajvazi, Judith Laure Folifack Tonfack, Luca Valgimigli, Riccardo Amorati
Limonene, linalool and citral are common non-phenolic terpenoid components of essential oils, with attributed controversial antioxidant properties. The kinetics of their antioxidant activity was investigated using the inhibited autoxidation of a standard model substrate. Results indicate that antioxidant behavior of limonene, linalool and citral occurs by co-oxidation with the substrate, due to very fast self-termination and cross-termination of the oxidative chain. Rate constants kp and 2kt, (M(-1)s(-1)) at 30°C were 4...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28446915/pruning-system-and-foliar-application-of-mgso-4-alter-yield-and-secondary-metabolite-profile-of-rosa-damascena-under-rainfed-acidic-conditions
#13
Probir K Pal, Mitali Mahajan
Damask rose (Rosa damascena Mill.) is one of the most high-value essential oil-bearing plants in the world. However, the flower yield and quality of essential oil of R. damascena are largely influenced by the pruning practices and balanced supply of plant nutrition. The objective of this study was to test the hypothesis whether the pruning system and foliar fertilization of MgSO4 would influence the flower yield, growth and secondary metabolites profile of R. damascena. A field experiment of 10 treatment combinations comprising two pruning systems (complete and partial) and five levels of MgSO4 (water spray, MgSO4 @ 5...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28422054/growth-inhibition-of-sulfate-reducing-bacteria-in-produced-water-from-the-petroleum-industry-using-essential-oils
#14
Pamella Macedo de Souza, Fátima Regina de Vasconcelos Goulart, Joana Montezano Marques, Humberto Ribeiro Bizzo, Arie Fitzgerald Blank, Claudia Groposo, Maíra Paula de Sousa, Vanessa Vólaro, Celuta Sales Alviano, Daniela Sales Alviano Moreno, Lucy Seldin
Strategies for the control of sulfate-reducing bacteria (SRB) in the oil industry involve the use of high concentrations of biocides, but these may induce bacterial resistance and/or be harmful to public health and the environment. Essential oils (EO) produced by plants inhibit the growth of different microorganisms and are a possible alternative for controlling SRB. We aimed to characterize the bacterial community of produced water obtained from a Brazilian petroleum facility using molecular methods, as well as to evaluate the antimicrobial activity of EO from different plants and their major components against Desulfovibrio alaskensis NCIMB 13491 and against SRB growth directly in the produced water...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28420101/the-effect-of-citrus-essential-oils-and-their-constituents-on-growth-of-xanthomonas-citri-subsp-citri
#15
Hossein Mirzaei-Najafgholi, Saeed Tarighi, Morteza Golmohammadi, Parissa Taheri
Citrus bacterial canker (CBC) caused by Xanthomonas citri subsp. citri (Xcc), is the most devastating of the citrus diseases worldwide. During our study, we found that Essential oils (EOs) of some citrus cultivars are effective on Xcc. Therefore, it prompted us to determine the plant metabolites responsible for the antibacterial properties. We obtained EOs from some locally cultivated citrus by using a Clevenger apparatus and their major constituents were identified by gas chromatography/mass spectrometry (GC-MS)...
April 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28351318/cytotoxicity-of-citral-against-melanoma-cells-the-involvement-of-oxidative-stress-generation-and-cell-growth-protein-reduction
#16
Larissa Juliani Sanches, Poliana Camila Marinello, Carolina Panis, Tatiane Renata Fagundes, José Andrés Morgado-Díaz, Julio Cesar Madureira de-Freitas-Junior, Rubens Cecchini, Alessandra Lourenço Cecchini, Rodrigo Cabral Luiz
Citral is a natural compound that has shown cytotoxic and antiproliferative effects on breast and hematopoietic cancer cells; however, there are few studies on melanoma cells. Oxidative stress is known to be involved in all stages of melanoma development and is able to modulate intracellular pathways related to cellular proliferation and death. In this study, we hypothesize that citral exerts its cytotoxic effect on melanoma cells by the modulation of cellular oxidative status and/or intracellular signaling...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28316634/anti-inflammatory-activity-of-the-essential-oil-citral-in-experimental-infection-with-staphylococcus-aureus-in-a-model-air-pouch
#17
Hellen Braga Martins, Nathan das Neves Selis, Clarissa Leal Silva E Souza, Flávia S Nascimento, Suzi Pacheco de Carvalho, Lorena D'Oliveira Gusmão, Jannine Dos Santos Nascimento, Anne Karoline Pereira Brito, Samira Itana de Souza, Marcio Vasconcelos de Oliveira, Jorge Timenetsky, Regiane Yatsuda, Ana Paula T Uetanabaro, Lucas M Marques
This study proposes to implement an alternative and effective strategy for local treatment of disease provoked by S. aureus. For the analysis of possible anti-inflammatory activity of essential oil, after establishing an air pouch model, 48 male mice of Balb/c were treated, infected, and euthanized at 4 and 8 h. Thus, the total and differential white blood cells were counted in the animal's blood, and cytokines IL-1β, IL-6, and TNF-α were titrated using ELISA in the air pouch lavage. Moreover, TNF-α, IL-1β, and IL-6 gene expression was analyzed through an RT-qPCR array, and S...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28250025/synthesis-of-apo-13-and-apo-15-lycopenoids-cleavage-products-of-lycopene-that-are-retinoic-acid-antagonists
#18
Sureshbabu Narayanasamy, Jian Sun, Ryan E Pavlovicz, Abdulkerim Eroglu, Cassandra E Rush, Benjamin D Sunkel, Chenglong Li, Earl H Harrison, Robert W Curley
Consumption of the tomato carotenoid, lycopene, has been associated with favorable health benefits. Some of lycopene's biological activity may be due to metabolites resulting from cleavage of the lycopene molecule. Because of their structural similarity to the retinoic acid receptor (RAR) antagonist, β-apo-13-carotenone, the "first half" putative oxidative cleavage products of the symmetrical lycopene have been synthesized. All transformations proceed in moderate to good yield and some with high stereochemical integrity allowing ready access to these otherwise difficult to obtain terpenoids...
May 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28235740/influence-of-metals-on-essential-oil-content-and-composition-of-lemongrass-cymbopogon-citratus-d-c-stapf-grown-under-different-levels-of-red-mud-in-sewage-sludge-amended-soil
#19
Meenu Gautam, Madhoolika Agrawal
Lemongrass is a commercially important perennial herb with medicinal value and ability to tolerate high alkaline and saline conditions. Essential oil bearing plants can grow safely in soil contaminated with heavy metals without severe effects on morphology and oil yield. The present study was aimed to assess the essential oil content and composition in lemongrass in response to elevated metals in above-ground plant parts. Pot experiment was conducted for six months using sewage sludge as soil amendment (soil: sludge: 2:1 w/w) followed by red mud treatments (0, 5, 10 and 15% w/w)...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28185379/feed-degradability-rumen-fermentation-and-blood-metabolites-in-response-to-essential-oil-addition-to-fistulated-non-lactating-dairy-cow-diets
#20
Wisitiporn Suksombat, Atitthan Nanon, Chayapol Meeprom, Pipat Lounglawan
The effects of essential oils (EOs) on ruminal nutrient disappearance, rumen fermentation and blood metabolites in fistulated non-lactating dairy cows were studied. Four fistulated non-lactaing dairy cows were used in a 4 × 4 Latin square design; the experiment consisted of four periods of 21 days in each period, with the first 14 days for adaptation followed by 7 days of measurement period. Animals were fed 3 kg/day of 21% crude protein (CP) concentrate and ad libitum corn silage. Treatments were: (i) control; (ii) 2 mL Allicin/cow/day; (iii) 2 mL zingiberene/cow/day; and (iv) 2 mL citral/cow/day...
February 9, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
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