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https://www.readbyqxmd.com/read/28093037/encapsulation-of-lemongrass-oil-with-cyclodextrins-by-spray-drying-and-its-controlled-release-characteristics
#1
Sarunya Phunpee, Uracha Rangsadthong Ruktanonchai, Hidefumi Yoshii, Suttichai Assabumrungrat, Apinan Soottitantawat
Inclusion of the two isomers of citral (E-citral and Z-citral), components of lemongrass oil, was investigated within the confines of various cyclodextrin (α-CD, β-CD and γ-CD) host molecules. Aqueous complex formation constants for E-citral with α-CD, β-CD and γ-CD were determined to be 123, 185, and 204 L/mol, respectively, whereas Z-citral exhibited stronger affinities (157, 206, and 253 L/mol, respectively). The binding trend γ-CD > β-CD > α-CD is a reflection of the more favorable geometrical accommodation of the citral isomers with increasing cavity size...
January 17, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28088731/biological-properties-of-citral-and-its-potential-protective-effects-against-cytotoxicity-caused-by-aspirin-in-the-iec-6-cells
#2
Hafsia Bouzenna, Najla Hfaiedh, Marie-Agnès Giroux-Metges, Abdelfattah Elfeki, Hélène Talarmin
Citral, 3,7-dimethyl-2,6-octadienal, is a key component of several essential oils extracted from lemon-scented herbal plants. The present study was designed to investigate the antioxidant activities of citral and assess its possible protective effects against aspirin-induced toxicity in vitro. We used IEC-6 cells (rat small intestine epithelial cells). The antioxidant activities were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH), β-carotene/linoleic acid and Ferric reducing antioxidant power (FRAP). Cytotoxicity was evaluated by cell viability, anti-oxidant enzyme activities, malondialdehyde (MDA) production and by the expression of MAPKs (Mitogen-Activated Protein Kinases) pathways...
January 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27979111/preparation-and-characterization-of-essential-oil-loaded-starch-nanoparticles-formed-by-short-glucan-chains
#3
Chao Qiu, Ranran Chang, Jie Yang, Shengju Ge, Liu Xiong, Mei Zhao, Man Li, Qingjie Sun
Essential oils (EOs), including menthone, oregano, cinnamon, lavender, and citral, are natural products that have antimicrobial and antioxidant activities. However, extremely low water solubility, and easy degradation by heat, restrict their application. The aim of this work was to evaluate the enhancement in antioxidative and antimicrobial activities of EOs encapsulated in starch nanoparticles (SNPs) prepared by short glucan chains. For the first time, we have successfully fabricated menthone-loaded SNPs (SNPs-M) at different complexation temperatures (30, 60, and 90°C) by an in situ nanoprecipitation method...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27976108/ginger-oil-and-its-active-ingredient-citral-relax-rat-airway-smooth-muscle-by-calcium-channel-blockade
#4
T Mangprayool, N Chudapongse
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27894210/protective-effects-of-lemongrass-essential-oil-against-benzo-a-pyrene-induced-oxidative-stress-and-dna-damage-in-human-embryonic-lung-fibroblast-cells
#5
Jiao Jiang, Henggui Xu, Hetong Wang, Yining Zhang, Ping Ya, Chun Yang, Fasheng Li
Benzo(a)pyrene (BaP) was a well-known environmental pollutant, numerous studies had implicated BaP as a causative agent in human cancer, particularly lung cancer. The lemongrass essential oil (LEO) possessed various pharmacological activities, especially the anti-oxidative stress and cancer prevention. In the current study, human embryonic lung fibroblast (HELF) cells were treated with 25 mM BaP in the absence or presence of 0.5%, 1% or 2.5% LEO and the cell viability and levels of oxidative stress (OS) and DNA damage in the cells were then measured...
December 28, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27877042/effects-of-carbopol-%C3%A2-934-proportion-on-nanoemulsion-gel-for-topical-and-transdermal-drug-delivery-a-skin-permeation-study
#6
Yin Zheng, Wu-Qing Ouyang, Yun-Peng Wei, Shahid Faraz Syed, Chao-Shuang Hao, Bo-Zhen Wang, Yan-Hong Shang
Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol(®) 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27859362/citral-stabilization-and-characterization-of-nanoemulsions-stabilized-by-a-mixture-of-gelatin-and-tween-20-in-an-acidic-system
#7
Huaixiang Tian, Danfeng Li, Ting Xu, Jing Hu, Yuzhi Rong, Bo Zhao
BACKGROUND: Citral is one of the most important flavor compounds in fresh juice and lemon oil. Unfortunately, citral is chemically unstable and degrades over time in aqueous solutions. Here, citral nanoemulsions including a mixture of gelatin and Tween 20 as emulsifiers were produced in an effort to maintain the stability of citral in an acidic system. RESULTS: The mean droplet size and polydispersity index (PDI) of the citral nanoemulsions were 467.83 nm and 0...
November 17, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27854038/biosynthesis-of-glycomonoterpenes-to-attenuate-quorum-sensing-associated-virulence-in-bacteria
#8
Amrita Patil, Kasturi Joshi-Navre, Ruchira Mukherji, Asmita Prabhune
The acquisition of multidrug resistance in bacteria has become a bigger threat of late, mainly due to the bacterial signaling phenomenon, quorum sensing (QS). QS, among a population of bacteria, initiates the formation of biofilms and offers myriad advantages to bacteria. Burgeoning antibiotic resistance in biofilm-producing bacteria has motivated efforts toward finding new alternatives to these traditional antimicrobials. In the present study, we report the increased solubility and additional quorum quenching as well as biofilm disruption activity of glyco-derivatives of monoterpenes (citral and citronellal)...
November 16, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27825341/essential-oils-in-vitro-activity-against-leishmania-amazonensis-cytotoxicity-and-chemical-composition
#9
Milene Aparecida Andrade, Clênia Dos Santos Azevedo, Flávia Nader Motta, Maria Lucília Dos Santos, Camila Lasse Silva, Jaime Martins de Santana, Izabela M D Bastos
BACKGROUND: The current chemotherapy for cutaneous leishmaniosis (CL) has a series of drug limitations such as toxic side effects, long duration, high costs and drug resistance, which requires the development of new drugs or effective alternatives to the CL treatment. Essential oils (EOs) are complex mixtures of secondary metabolites from various plants. It has been shown that several EOs, or their constituents, have inhibitory activity against protozoa. Thus, this study aims to evaluate the biological activity of different essential oils (EOs) on Leishmania (L...
November 8, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27802570/overall-quality-properties-of-kiwifruit-treated-by-cinnamaldehyde-and-citral-microbial-antioxidant-capacity-during-cold-storage
#10
Yuan Wang, Tingting Shan, Yahong Yuan, Tianli Yue
This work was undertaken to evaluate the microbiological characteristics and antioxidant and physiological activities in kiwifruits (Actinida deliciosa var. Qinmei) with/without cinnamaldehyde (C1) and citral (C2) fumigation treatments (5 μL/L) during 0, 3, 6, 9, and 12 d of storage at 4 °C. Essential oils (EOs) treatment lowered the total viable counts, yeast, and mold to 1.54, 2.36, and 2.05 log CFU/g, respectively. Moreover, EOs improved the antioxidant activities of kiwifruit. They enhanced phenolics and flavonoids content in fruit tissue by 49...
December 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27784920/the-effect-of-ginger-and-garlic-addition-during-cooking-on-the-volatile-profile-of-grass-carp-ctenopharyngodon-idella-soup
#11
Jin-Lin Li, Zong-Cai Tu, Lu Zhang, Xiao-Mei Sha, Hui Wang, Juan-Juan Pang, Ping-Ping Tang
Ginger and garlic have long been used in Asian countries to enhance the flavor and to neutralize any unpleasant odors present in fish soup. The purpose of this study was to evaluate the change in the amount of volatile components present in fish soup compared to boiled water solutions of ginger and garlic. The fish soup was prepared by boiling oil-fried grass carp (Ctenopharyngodon idella) with or without ginger and/or garlic. Generally, boiling garlic and ginger in water led to a decrease in the amount of the principal volatile constituents of these spices, together with the formation of some new volatiles such as pentanal, hexanal, and nonanal...
August 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27782845/chemical-composition-anthelmintic-antibacterial-and-antioxidant-effects-of-thymus-bovei-essential-oil
#12
Nidal Jaradat, Lina Adwan, Shadi K'aibni, Naser Shraim, Abdel Naser Zaid
BACKGROUND: It has been recently recognized that oxidative stress, helminth and microbial infections are the cause of much illness found in the underdeveloped, developing and developed countries. The present study was undertaken to identify the chemical composition, and to assess anthelmintic, antimicrobial and antioxidant effects of Thymus bovei essential oil. METHODS: The chemical composition of the essential oil was analyzed using gas chromatography mass spectrometry (GC-MS)...
October 26, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27765606/effect-of-lippia-alba-and-cymbopogon-citratus-essential-oils-on-biofilms-of-streptococcus-mutans-and-cytotoxicity-in-cho-cells
#13
A Tofiño-Rivera, M Ortega-Cuadros, D Galvis-Pareja, H Jiménez-Rios, L J Merini, M C Martínez-Pabón
BACKGROUND: Caries is a public health problem, given that it prevails in 60 to 90% of the school-age global population. Multiple factors interact in its etiology, among them dental plaque is necessary to have lactic acid producing microorganisms like Streptococcus from he Mutans group. Existing prevention and treatment measures are not totally effective and generate adverse effects, which is why it is necessary to search for complementary strategies for their management. AIM: The study sought to evaluate the eradication capacity of Streptococcus mutans biofilms and the toxicity on eukaryotic cells of Lippia alba and Cymbopogon citratus essential oils...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27755863/adverse-phototoxic-effect-of-essential-plant-oils-on-nih-3t3-cell-line-after-uv-light-exposure
#14
Svatopluk Binder, Adéla Hanáková, Kateřina Tománková, Klára Pížová, Robert Bajgar, Barbora Manišová, Kristina Kejlová, Hana Bendová, Dagmar Jírová, Hana Kolářová
AIM: Natural or artificial substances have become an inseparable part of our lives. It is questionable whether adequate testing has been performed in order to ensure these substances do not pose a serious health risk. The principal aim of our research was to clarify the potential risk of adding essential oils to food, beverages and cosmetic products. METHODS: The toxicity of substances frequently employed in cosmetics, aromatherapy and food industry (bergamot oil, Litsea cubeba oil, orange oil, citral) were investigated using cell line NIH3T3 (mouse fibroblasts) with/without UV irradiation...
September 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/27752443/natural-personal-care-products-analysis-of-ingredient-lists-and-legal-situation
#15
Ursula Klaschka
BACKGROUND: Many natural substances are classified as dangerous substances according to the European regulation on classification and labelling. Are they used in natural personal care products today? One hundred ingredient lists were analyzed to find this out. RESULTS: All products with natural substances contained dangerous natural substances or they contained natural substances, for which the information about their classification as dangerous substances is not available...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27742357/metabolism-of-citral-the-major-constituent-of-lemongrass-oil-in-the-cabbage-looper-trichoplusia-ni-and-effects-of-enzyme-inhibitors-on-toxicity-and-metabolism
#16
Jun-Hyung Tak, Murray B Isman
Although screening for new and reliable sources of botanical insecticides remains important, finding ways to improve the efficacy of those already in use through better understanding of their modes-of-action or metabolic pathways, or by improving formulations, deserves greater attention as the latter may present lesser regulation hurdles. Metabolic processing of citral (a combination of the stereoisomers geranial and neral), a main constituent of lemongrass (Cymbopogon citratus) essential oil has not been previously examined in insects...
October 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27710890/development-and-validation-of-reverse-phase-high-performance-liquid-chromatography-for-citral-analysis-from-essential-oils
#17
Roopa Gaonkar, S Yallappa, B L Dhananjaya, Gurumurthy Hegde
Citral is a widely used monoterpene aldehyde in aromatherapy, food and pesticide industries. A new validated reverse phase high performance liquid chromatography (RP - HPLC) procedure for the detection and quantification of cis-trans isomers of citral was developed. The RP-HPLC analysis was carried out using Enable C - 18G column (250×4.6mm, 5μ), with acetonitrile and water (70: 30) mobile phase in isocratic mode at 1mL/min flow. A photodiode array (PDA) detector was set at 233nm for the detection of citral...
November 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27592281/citral-reduces-breast-tumor-growth-by-inhibiting-the-cancer-stem-cell-marker-aldh1a3
#18
Margaret Lois Thomas, Roberto de Antueno, Krysta Mila Coyle, Mohammad Sultan, Brianne Marie Cruickshank, Michael Anthony Giacomantonio, Carman Anthony Giacomantonio, Roy Duncan, Paola Marcato
Breast cancer stem cells (CSCs) can be identified by increased Aldefluor fluorescence caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as ALDH1A1 and ALDH2. In addition to being a CSC marker, ALDH1A3 regulates gene expression via retinoic acid (RA) signaling and plays a key role in the progression and chemotherapy resistance of cancer. Therefore, ALDH1A3 represents a druggable anti-cancer target of interest. Since to date, there are no characterized ALDH1A3 isoform inhibitors, drugs that were previously described as inhibiting the activity of other ALDH isoforms were tested for anti-ALDH1A3 activity...
November 2016: Molecular Oncology
https://www.readbyqxmd.com/read/27562470/antimicrobial-activity-cytotoxicity-and-chemical-analysis-of-lemongrass-essential-oil-cymbopogon-flexuosus-and-pure-citral
#19
Emmanuel C Adukwu, Melissa Bowles, Valerie Edwards-Jones, Heather Bone
The aim of this study was to determine the antimicrobial effects of lemongrass essential oil (C. flexuosus) and to determine cytotoxic effects of both test compounds on human dermal fibroblasts. Antimicrobial susceptibility screening was carried out using the disk diffusion method. Antimicrobial resistance was observed in four of five Acinetobacter baumannii strains with two strains confirmed as multi-drug-resistant (MDR). All the strains tested were susceptible to both lemongrass and citral with zones of inhibition varying between 17 to 80 mm...
November 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27529236/immunosuppressive-effect-of-litsea-cubeba-l-essential-oil-on-dendritic-cell-and-contact-hypersensitivity-responses
#20
Hsin-Chun Chen, Wen-Te Chang, You-Cheng Hseu, Hsing-Yu Chen, Cheng Hsuan Chuang, Chi-Chen Lin, Meng-Shiou Lee, Ming-Kuem Lin
Litsea cubeba L., also named as Makauy, is a traditional herb and has been used as cooking condiment or tea brewing to treat diseases for aborigines. The present study was undertaken to explore the chemical compositions of the fruit essential oil of L. cubeba (LCEO) and the immunomodulatory effect of LCEO on dendritic cells and mice. The LCEO was analyzed using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) with direct injection (DI/GC) or headspace-solid phase microextraction (HS-SPME/GC)...
August 12, 2016: International Journal of Molecular Sciences
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