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https://www.readbyqxmd.com/read/29334186/natural-humic-acid-based-phototheranostic-agent
#1
Zhao-Hua Miao, Kai Li, Pei-Ying Liu, Zhenglin Li, Huanjie Yang, Qingliang Zhao, Manli Chang, Qingzhu Yang, Liang Zhen, Cheng-Yan Xu
Humic acids, a major constituent of natural organic carbon resources, are naturally formed through the microbial biodegradation of animal and plant residues. Due to numerous physiologically active groups (phenol, carboxyl, and quinone), the biomedical applications of humic acid have been already investigated across different cultures for several centuries or even longer. In this work, sodium humate, the sodium salt of humic acid, is explored as phototheranostic agent for light-induced photoacoustic imaging and photothermal therapy based on intrinsic absorption in the near-infrared region...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29333572/possible-protective-effect-of-the-algae-spirulina-against-nephrotoxicity-induced-by-cyclosporine-a-and-or-gamma-radiation-in-rats
#2
Maha M Aziz, Nihad I Eid, Ahmed S Nada, Nour El-Din Amin, Afaf A Ain-Shoka
The present study was conducted to evaluate the possible protective role of the algae spirulina (Sp) against nephrotoxicity and oxidative stress which are the main secondary effects induced by the immunosuppressant drug CSA and/or ionizing radiation. In this study, male rats were given Sp (1 g/kg) either for 15 days before irradiation (6.5 Gy) or 5 days before and 10 days concomitant with CSA (25 mg/kg). Markers used to assess renal injury included serum creatinine, urea, glucose, albumin, protein, and lipid profile as well as kidney content of reduced glutathione (GSH); lipid peroxidation (thiobarbituric acid reactive substances (TBARS)); nitrite and superoxide dismutase (SOD) activity...
January 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29333379/broccoli-brassica-oleracea-reduces-oxidative-damage-to-pancreatic-tissue-and-combats-hyperglycaemia-in-diabetic-rats
#3
Sithara Suresh, Mostafa Ibrahim Waly, Mohammad Shafiur Rahman, Nejib Guizani, Mohamed Abdullah Badar Al-Kindi, Halima Khalfan Ahmed Al-Issaei, Sultan Nasser Mohd Al-Maskari, Bader Rashid Said Al-Ruqaishi, Ahmed Al-Salami
Oxidative stress plays a pivotal role in the development of diabetes and hyperglycaemia. The protective effects of natural extracts against diabetes are mainly dependent on their antioxidant and hypoglycaemic properties. Broccoli (Brassica oleracea) exerts beneficial health effects in several diseases including diabetes; however, the mechanism has not been elucidated yet. The present study was carried out to evaluate the potential hypoglycaemic and antioxidant properties of aqueous broccoli extracts (BEs) in diabetic rats...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29333041/pharmacological-evaluation-of-hepatoprotective-activity-of-ahpl-aytab-0613-tablet-in-carbon-tetrachloride-ethanol-and-paracetamol-induced-hepatotoxicity-models-in-wistar-albino-rats
#4
Sanjay U Nipanikar, Sohan S Chitlange, Dheeraj Nagore
Background: Hepatotoxicity ultimately leads to liver failure. Conventional treatment options for hepatotoxicity are limited and not safe. Objective: Formulation AHPL/AYTAB/0613 is developed to provide safer and effective hepatoprotective drug of natural origin. A study was conducted to evaluate hepatoprotective activity of AHPL/AYTAB/0613 (three dosages) in comparison with marketed formulations in carbon tetrachloride (CCl4), ethanol, and paracetamol-induced hepatotoxicity in Wistar albino rats...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332602/nanoemulsion-strategy-for-ursolic-and-oleanic-acids-isolates-from-plumeria-obtusa-improves-antioxidant-and-cytotoxic-activity-in-melanoma-cells
#5
Helen L Alvarado, Ana C Calpena, Maria L Garduno-Ramirez, Raul Ortiz, Consolacion Melguizo, Jose M Prados, Beatriz Clares
BACKGROUND: Triterpenoids are an important class of natural bioactive products present in many medicinal plants. OBJECTIVE: The aim of present study is to investigate the antioxidant and anticarcinogenic potential of oleanolic acid (OA) and ursolic acid (UA) on B16 murine melanoma cell line isolated from Plumeria obtusa, free and loaded in a nanoemulsion (NEm) system. METHOD: The nanoemulsion was characterized by dynamic light scattering, transmission electron microscopy...
January 11, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29332583/eating-green-shining-light-on-the-use-of-dietary-phytochemicals-as-a-modern-approach-in-the-prevention-and-treatment-of-head-and-neck-cancers
#6
Linda L Eastham, Candace M Howard, Premalatha Balachandran, David S Pasco, Pier Paolo Claudio
Enthusiasm for the use of dietary bioactive compounds as chemopreventive agents and adjuvants for current therapies has increased laboratory research conducted on several types of cancers including Head and Neck Squamous Cell Carcinoma (HNSCC). The green chemoprevention movement is a modern approach to highlight healthy lifestyle changes that aim to decrease the incidence of HNSCC. A healthy diet can be an effective way to prevent the development of oral cancers. Discovery of the naturally occurring plant based compounds called phytochemicals has facilitated the development of new treatment strategies for patients that are at risk for, or have developed HNSCC...
January 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29331809/environmental-behavior-of-coated-nms-physicochemical-aspects-and-plant-interactions
#7
REVIEW
Martha L López-Moreno, Yarilyn Cedeño-Mattei, Sonia Janet Bailón-Ruiz, Edgar Vazquez-Nuñez, José A Hernandez-Viezcas, Oscar Juan Perales-Pérez, Guadalupe De la Rosa, José R Peralta-Videa, Jorge L Gardea-Torresdey
The application of nanomaterials (NMs) depends on several characteristics, including polydispersity, shape, surface charge, and composition, among others. However, the specific surface properties of bare NMs induce aggregation, reducing their utilization. Thus, different surface coverages have been developed to avoid or minimize NMs aggregation, making them more stable for the envisioned applications. Carbon-based NMs are usually coated with metals, while metal-based NMs are coated with natural organic compounds including chitosan, dextran, alginate, or citric acid...
December 25, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29331510/effects-of-sub-minimum-inhibitory-concentrations-of-lemon-essential-oil-on-the-acid-tolerance-and-biofilm-formation-of-streptococcus-mutans
#8
Yanwei Sun, Sijia Chen, Chen Zhang, Yali Liu, Li Ma, Xiangyu Zhang
OBJECTIVES: Lemon essential oil (LEO) is a kind of secondary metabolite from lemon peels and has been found to inhibit cariogenic bacteria for decades. However, its effects on main cariogenic virulence factors are rarely reported. The present study aimed to investigate the effects of sub-minimum inhibitory concentrations (sub-MICs) of LEO on the acid tolerance and biofilm formation of Streptococcus mutans (S. mutans) and preliminarily reveal the possible underlying mechanisms. DESIGNS: Effects of LEO on the acid tolerance and biofilm formation of S...
December 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29331487/curecuma-cationic-curcuminoids-with-improved-properties-and-enhanced-antimicrobial-photodynamic-activity
#9
Andreas Spaeth, Andre Graeler, Tim Maisch, Kristjan Plaetzer
The naturally occurring photosensitizer curcumin has excellent biocompatibility, but its antimicrobial photodynamic efficacy is limited by (i) weak adherence to Gram(-) cell walls, (ii) low (photo-)stability and (iii) limited solubility in water. In this study novel curcuminoids bearing cationic substituents were prepared by different synthetic routes. The derivatives exhibit excellent water solubility, improved photostability and low aggregation. All novel curcuminoids showed antibacterial photodynamic effects (>3 log10 reduction of CFU) against Escherichia coli and Staphylococcus aureus upon blue light illumination...
October 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29331332/hiv-infection-and-its-effects-on-the-development-of-autoimmune-disorders
#10
REVIEW
Luis E Vega, Luis R Espinoza
More than 35 years have elapsed since the initial outbreak of the HIV/AIDS epidemic and the status of a considerable number of patients has changed from a fatal disorder to a chronic one where comorbidities including sarcoidosis and autoimmune diseases have become relevant and dominant. HIV targets the immune system leading to a state of immunodeficiency in a setting of immune activation in which CD4+ T cell depletion plays a critical role. The onset, natural history and course of HIV-associated autoimmune disease has dramatically changed according to the stage of HIV infection and since the introduction of combined anti-retroviral therapy...
January 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29331315/ethnobotany-phytochemistry-and-pharmacology-of-arctotis-arctotoides-l-f-o-hoffm-a-review
#11
REVIEW
Md Moshfekus Saleh-E-In, Johannes Van Staden
ETHNOPHARMACOLOGICAL RELEVANCE: Arctotis arctotoides (Asteraceae) is part of the genus Arctotis. Arctotis is an African genus of approximately 70 species that occur widely in the African continent with diverse medicinal values. This plant is used for the treatment of indigestion and catarrh of the stomach, epilepsy, topical wounds and skin disorders among the ethnic groups in South Africa and reported to have a wide spectrum of pharmacological properties. AIM OF THE REVIEW: The aim of the present review is to appraise the botany, traditional uses, phytochemistry, pharmacological potential, analytical methods and safety issues of A...
January 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29330866/enteric-viruses-dissemination-in-a-private-reserve-of-natural-heritage
#12
T M Fumian, M Victoria, C B Vieira, J M Fioretti, M S Rocha, T Prado, F R Guimarães, N P da Gama, J M de Oliveira, A C O Mendes, A M C Gaspar, J D O Santos, M Chame, J P G Leite, M P Miagostovich
This study aimed to assess anthropogenic impact of surrounding population in the Private Reserve of Natural Heritage at Pantanal, the world's largest freshwater wetland ecosystem located in the center of South America. Viral etiologic agents of acute gastroenteritis as rotavirus A (RVA), noroviruses (NoV), human adenoviruses (HAdV), klassevirus (KV) and of hepatitis, as hepatitis A virus (HAV), were investigated in different aquatic matrices. Annual collection campaigns were carried out from 2009 to 2012, alternating dry and rainy seasons...
January 13, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29330592/genomic-characterization-of-key-bacteriophages-to-formulate-the-potential-biocontrol-agent-to-combat-enteric-pathogenic-bacteria
#13
Krupa M Parmar, Nishant A Dafale, Hitesh Tikariha, Hemant J Purohit
Combating bacterial pathogens has become a global concern especially when the antibiotics and chemical agents are failing to control the spread due to its resistance. Bacteriophages act as a safe biocontrol agent by selectively lysing the bacterial pathogens without affecting the natural beneficial microflora. The present study describes the screening of prominent enteric pathogens NDK1, NDK2, NDK3, and NDK4 (Escherichia, Klebsiella, Enterobacter, and Serratia) mostly observed in domestic wastewater; against which KNP1, KNP2, KNP3, and KNP4 phages were isolated...
January 12, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29330479/titania-tio2-nanoparticles-enhance-the-performance-of-growth-promoting-rhizobacteria
#14
Salme Timmusk, Gulaim Seisenbaeva, Lawrence Behers
A novel use of nanotitania (TNs) as agents in the nanointerface interaction between plants and colonization of growth promoting rhizobacteria (PGPR) is presented. The effectiveness of PGPRs is related to the effectiveness of the technology used for their formulation. TNs produced by the Captigel patented SolGel approach, characterized by the transmission and scanning electron microscopy were used for formulation of the harsh environment PGPR strains. Changes in the biomass of wheat seedlings and in the density of single and double inoculants with and without TNs were monitored during two weeks of stress induced by drought salt and by the pathogen Fusarium culmorum...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330304/efficient-prion-disease-transmission-through-common-environmental-materials
#15
Sandra Pritzkow, Rodrigo Morales, Adam Lyon, Luis Concha-Marambio, Akihiko Urayama, Claudio Soto
Prion diseases are a group of fatal neurodegenerative diseases associated with a protein-based infectious agent, termed prion. Compelling evidence suggests that natural transmission of prion diseases is mediated by environmental contamination with infectious prions. We hypothesized that several natural and man-made materials, commonly found in the environments of wild and captive animals, can bind prions and may act as vectors for disease transmission. To test our hypothesis, we exposed surfaces composed of various common environmental materials (i...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29329812/synergistic-effect-of-polysaccharides-betalain-pigment-and-phenolic-compounds-of-red-prickly-pear-opuntia-stricta-in-the-stabilization-of-salami
#16
Nadia Kharrat, Hedia Salem, Aicha Mrabet, Fatma Aloui, Soumaya Triki, Ahmed Fendri, Youssef Gargouri
The aim of this work is to try to substitute some synthetic additives by a natural extract from red prickly pear (Opuntia stricta) which known by its richness on bioactive polysaccharides mainly consisting of galactose, rhamnose and galacturonic acid. This natural fruit has a high content of carbohydrates above 18.81% FM. It contains also a high level of polyphenols 152.25 ± 0.26 μg QE/mg PPE and flavonoids about 370.60 ± 0.12 μg GAE/mg of PPE. In addition, prickly pear extract (PPE) displayed a strong antioxidant and antimicrobial activities...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329666/advances-in-self-healing-materials-based-on-vascular-networks-with-mechanical-self-repair-characteristics
#17
REVIEW
Min Wook Lee, Seongpil An, Sam S Yoon, Alexander L Yarin
Here, we review the state-of-the-art in the field of engineered self-healing materials. These materials mimic the functionalities of various natural materials found in the human body (e.g., the healing of skin and bones by the vascular system). The fabrication methods used to produce these "vascular-system-like" engineered self-healing materials, such as electrospinning (including co-electrospinning and emulsion spinning) and solution blowing (including coaxial solution blowing and emulsion blowing) are discussed in detail...
December 24, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29329644/anticancer-carbazole-alkaloids-and-coumarins-from-clausena-plants-a-review
#18
REVIEW
Li Huang, Zhe-Ling Feng, Yi-Tao Wang, Li-Gen Lin
Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329339/accessibility-and-contribution-to-glucan-masking-of-natural-and-genetically-tagged-versions-of-yeast-wall-protein-1-of-candida-albicans
#19
Bruce L Granger
Yeast wall protein 1 (Ywp1) is an abundant glycoprotein of the cell wall of the yeast form of Candida albicans, the most prevalent fungal pathogen of humans. Antibodies that bind to the polypeptide backbone of isolated Ywp1 show little binding to intact yeast cells, presumably because the Ywp1 epitopes are masked by the polysaccharides of the mannoproteins that form the outer layer of the cell wall. Rare cells do exhibit much greater anti-Ywp1 binding, however, and one of these was isolated and characterized...
2018: PloS One
https://www.readbyqxmd.com/read/29329277/synthesis-structural-characterization-antimicrobial-activity-and-in-vitro-biocompatibility-of-new-unsaturated-carboxylate-complexes-with-2-2-bipyridine
#20
Gina Vasile Scăețeanu, Mariana Carmen Chifiriuc, Coralia Bleotu, Crina Kamerzan, Luminiţa Măruţescu, Constantin G Daniliuc, Cătălin Maxim, Larisa Calu, Rodica Olar, Mihaela Badea
The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2'-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn₃(2,2'-bipy)₂(C₃H₃O₂)₆] (1), meanwhile complexes with general formula [M(2,2'-bipy)(C₃H₃O₂)₂(H₂O)x]∙yH₂O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2'-bipy: 2,2'-bipyridine; C₃H₃O₂: acrylate anion) were shown to be mononuclear...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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