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https://www.readbyqxmd.com/read/28819359/screening-for-cushing-syndrome-at-the-primary-care-level-what-every-general-practitioner-must-know
#1
REVIEW
Ernest Yorke, Yacoba Atiase, Josephine Akpalu, Osei Sarfo-Kantanka
Cushing's syndrome is a rare entity, and a high index of suspicion is needed for screening in a primary care setting. The clinical awareness of the primary care physician (PCP) to the highly indicative signs and symptoms such as facial plethora, proximal myopathy, reddish purple striae, and easy bruisability should alert him to look for biochemical evidence of Cushing's syndrome through any of the first-line screening tests, namely, 24-hour urinary free cortisol, overnight dexamethasone suppression test, or late-night salivary cortisol...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28817353/measuring-mental-workload-with-the-nasa-tlx-needs-to-examine-each-dimension-rather-than-relying-on-the-global-score-an-example-with-driving
#2
Edith Galy, Julie Paxion, Catherine Berthelon
The distinction between several components of mental workload is often made in the ergonomics literature. However, measurements used are often established from a global score, notably with several questionnaires that originally reflect several dimensions. The present study tested the effect of driving situation complexity, experience and subjective levels of tension and alertness on each dimension of the NASA-TLX questionnaire of workload, in order to highlight the potential influence of intrinsic, extraneous and germane load factors...
August 17, 2017: Ergonomics
https://www.readbyqxmd.com/read/28816343/application-of-n-of-1-experiments-to-test-the-efficacy-of-inactivity-alert-features-in-fitness-trackers-to-increase-breaks-from-sitting-in-older-adults
#3
Dori E Rosenberg, Elyse Kadokura, Margaret E Morris, Anne Renz, Roger M Vilardaga
BACKGROUND: Frequent breaks from sitting could improve health. Many commercially available fitness trackers deliver vibration alerts that could be used to cue sitting breaks. As a potentially pragmatic approach to promote frequent breaks from sitting, we tested the efficacy of inactivity alerts among obese older adults, a highly sedentary population. METHODS: We conducted 10 sequential N-of-1 (single-case) experimental ABA trials. Participants (mean age = 68, mean BMI = 35) were monitored for a baseline phase ("A1") followed by an intervention phase ("B")...
August 16, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28811594/spatio-temporal-variations-of-pm2-5-concentrations-and-the-evaluation-of-emission-reduction-measures-during-two-red-air-pollution-alerts-in-beijing
#4
Nianliang Cheng, Dawei Zhang, Yunting Li, Xiaoming Xie, Ziyue Chen, Fan Meng, Bingbo Gao, Bin He
To effectively improve air quality during pollution episodes, Beijing released two red alerts in 2015. Here we examined spatio-temporal variations of PM2.5 concentrations during two alerts based on multiple data sources. Results suggested that PM2.5 concentrations varied significantly across Beijing. PM2.5 concentrations in southern parts of Beijing were higher than those in northern areas during both alerts. In addition to unfavorable meteorological conditions, coal combustion, especially incomplete coal combustion contributed significantly to the high PM2...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807047/adverse-outcomes-associated-with-opioid-prescription-for-acute-low-back-pain-a-systematic-review-protocol
#5
Natalia Mouravska, Laura Zielinski, Meha Bhatt, Nitika Sanger, Monica Bawor, Brittany Dennis, Laura Banfield, James MacKillop, James Paul, Andrew Worster, Philip Laplante, Lehana Thabane, Zainab Samaan
BACKGROUND: Acute low back pain (ALBP) is the top cause of global disability, demonstrating a significant impact on individuals and society and demanding the need for appropriate management. There is a trend towards an increasing number of opioid prescriptions for ALBP despite the lack of investigation for its various short- and long-term outcomes. The objective of this review is to examine adverse outcomes associated with opioid use for ALBP. METHODS/DESIGN: Using a search strategy, the search will be conducted using the following electronic databases: PubMed/MEDLINE, EMBASE, PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, Cochrane Library, the National Institutes for Health Clinical Trials Registry and the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP)...
August 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28807035/artemisinin-combination-therapy-mass-drug-administration-in-a-setting-of-low-malaria-endemicity-programmatic-coverage-and-adherence-during-an-observational-study-in-zanzibar
#6
Abdullah S Ali, Narjis G Thawer, Bakar Khatib, Haji H Amier, Joseph Shija, Mwinyi Msellem, Abdul-Wahid Al-Mafazy, Issa A Garimo, Humphrey Mkali, Mahdi M Ramsan, Jessica M Kafuko, Lynn A Paxton, Richard Reithinger, Jeremiah M Ngondi
BACKGROUND: Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia. This study reports on programmatic coverage and compliance of MDA using artemisinin-based combination therapy (ACT) in four shehias (smallest administration unit) that had been identified as hotspots through Zanzibar's malaria case notification surveillance system. METHODS: Mass drug administration was done in four shehias selected on the basis of: being an established malaria hot spot; having had mass screening and treatment (MSaT) 2-6 weeks previously; and exceeding the epidemic alert threshold of 5 cases within a week even after MSaT...
August 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28796791/evaluating-turnaround-times-for-early-infant-diagnosis-samples-in-kenya-from-2011-2014-a-retrospective-analysis-of-hitsystem-program-data
#7
Catherine Wexler, An-Lin Cheng, Brad Gautney, Sarah Finocchario-Kessler, Kathy Goggin, Samoel Khamadi
Long turnaround times (TAT) for the processing and posting of results of infant HIV DNA PCR samples can hinder the success of early infant diagnosis (EID) programs. The HITSystem is an eHealth intervention that alerts staff when services are overdue or results are delayed. We conducted a retrospective analysis of 3669 HIV-exposed infants enrolled in 15 Kenya hospital EID programs and three laboratories using the HITSystem from 2011-2014. We assessed mean and median TAT from when a sample was: 1) obtained to when it was shipped to the laboratory, 2) shipped to when it was received at the laboratory, 3) received to when a result was posted, and 4) the total time from obtaining the sample (step 1) to posting the result (step 3)...
2017: PloS One
https://www.readbyqxmd.com/read/28791158/gamma-ray-bursts-and-their-use-as-cosmic-probes
#8
REVIEW
Patricia Schady
Since the launch of the highly successful and ongoing Swift mission, the field of gamma-ray bursts (GRBs) has undergone a revolution. The arcsecond GRB localizations available within just a few minutes of the GRB alert has signified the continual sampling of the GRB evolution through the prompt to afterglow phases revealing unexpected flaring and plateau phases, the first detection of a kilonova coincident with a short GRB, and the identification of samples of low-luminosity, ultra-long and highly dust-extinguished GRBs...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28782093/metabolic-acidosis-caused-by-concomitant-use-of-paracetamol-acetaminophen-and-flucloxacillin-a-case-report-and-a-retrospective-study
#9
J K Berbee, L A Lammers, C T P Krediet, J C Fischer, E M Kemper
PURPOSE: A patient was identified with severe metabolic acidosis, a high anion gap and 5-oxoproline accumulation, probably caused by the simultaneous use of paracetamol (acetaminophen) and flucloxacillin. We wanted to investigate the necessity to control the interaction between both drugs with an automatic alert system. METHODS: To investigate the relevance of the interaction of paracetamol and flucloxacillin, a retrospective study was conducted. Data on paracetamol and flucloxacillin prescriptions and laboratory data (pH, Na(+), HCO3(-), Cl(-), albumin and 5-oxoproline levels) were combined to assess the prevalence of acidosis, calculate the anion gap and analyse 5-oxoproline levels in clinically admitted patients using both drugs simultaneously...
August 7, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28781802/sorafenib-induced-reversible-posterior-leukoencephalopathy-in-patients-with-renal-cell-carcinoma-a-report-of-two-cases
#10
Nobuki Furubayashi, Takahito Negishi, Hidenori Iwai, Kei Nagase, Motonobu Nakamura
Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare clinicoradiological syndrome that is characterized by neurological symptoms, including seizures, headaches, visual abnormalities, confusion and encephalopathy, accompanied by vasogenic edema of the posterior white matter observed on neuroimaging. Sorafenib is an inhibitor of pro-angiogenic receptor tyrosine kinases, such as vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and vascular endothelial growth factor receptor 3...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28777952/influence-of-fat-and-oil-type-on-the-yield-physico-chemical-properties-and-microstructure-of-fat-oil-and-grease-fog-deposits
#11
Dann Marie N Del Mundo, Manote Sutheerawattananonda
Fat, oil, and grease (FOG) deposit, in the form of calcium soap, was found to cause sanitary sewer overflows due to its adhesion on pipe walls. To address this problem, laboratory-prepared calcium soaps have been used to investigate the formation mechanisms of FOG deposits. However, the fats and oils previously utilized were limited and some soap characteristics were not examined. This research attempted to probe through the properties of calcium soaps prepared from calcium chloride and the fats and oils of chicken, pork, palm olein, soybean, olive, and coconut to further understand FOG formation and stability...
July 21, 2017: Water Research
https://www.readbyqxmd.com/read/28777361/-associations-between-chronotype-road-accidents-and-polymorphisms-in-genes-linked-with-biological-clock-and-dopaminergic-system
#12
A O Taranov, A N Puchkova, P A Slominsky, T V Tupitsyna, V V Dementiyenko, V B Dorokhov
Public transport driving is a highly demanding activity requiring high skills and responsibility. Shift work, problems with regular sleep schedule negatively impact psychomotor reactions, cognitive functions and ability to react appropriately to the changing environment. For professional drivers all these factors may lead to the increased risk of a road accident. Individual differences in chronotype, cognitive and emotional control are partially genetically determined. AIM: Our study aimed to investigate the possible associations between chronotype parameters, traffic accident history and single nucleotide polymorphisms (SNPs) in a number of genes: RORA (rs1159814), CLOCK (rs12649507), PER3 (rs2640909), NPSR1 (rs324981), NPAS2 (rs4851377), DRD3 (rs6280), SLC6A3 (rs6347), DBH (rs1611125)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28776437/warfarin-monitoring-in-nursing-homes-assessed-by-case-histories-do-recommendations-and-electronic-alerts-affect-judgements
#13
Reyes Serrano Teruel, Geir Thue, Svein Ivar Fylkesnes, Sverre Sandberg, Ann Helen Kristoffersen
PURPOSE: Older adults treated with warfarin are prone to complications, and high-quality monitoring is essential. The aim of this case history based study was to assess the quality of warfarin monitoring in a routine situation, and in a situation with an antibiotic-warfarin interaction, before and after receiving an electronic alert. MATERIALS AND METHODS: In April 2014, a national web-based survey with two case histories was distributed among Norwegian nursing home physicians and general practitioners working part-time in nursing homes...
August 4, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28774441/a-real-time-stress-classification-system-based-on-arousal-analysis-of-the-nervous-system-by-an-f-state-machine
#14
R Martinez, E Irigoyen, A Arruti, J I Martin, J Muguerza
BACKGROUND AND OBJECTIVE: Detection and labelling of an increment in the human stress level is a contribution focused principally on improving the quality of life of people. This work is aimed to develop a biophysical real-time stress identification and classification system, analysing two noninvasive signals, the galvanic skin response and the heart rate variability. METHODS: An experimental procedure was designed and configured in order to elicit a stressful situation that is similar to those found in real cases...
September 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28766503/could-biochemistry-lab-alert-for-low-alkaline-phosphatase-prompt-diagnosis-of-hypophosphatasia
#15
Asma Deeb, Elfatih Abubaker
OBJECTIVE: Hypophosphatasia (HPP) is an inborn error of metabolism with significant morbidity and mortality. Its presentation is non-specific leading to delay or missed diagnosis. Low ALP is a diagnostic test. Unlike high ALP, low level is commonly un-flagged by laboratories as abnormal. A new treatment has proved to be effective in HPP. We aim to study frequency of flagging of low ALP level by laboratory and the clinical manifestations of patients presenting with low ALP for a possible diagnosis of HPP...
August 2, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28765791/coronary-artery-disease-presenting-with-left-upper-quadrant-pain-in-a-patient-with-chronic-cervical-tetraplegia
#16
Lianne Michelle Nier, Peter S Hansen
INTRODUCTION: This single-subject case report aims to describe and discuss a case of a patient with established C5 tetraplegia with acute coronary syndrome presenting with left upper quadrant pain and tenderness. CASE PRESENTATION: A 65-year-old male with chronic C5 American Spinal Injury Association Impairment Scale (AIS) A tetraplegia presented to the emergency department with severe left upper quadrant pain radiating across the chest to the right upper limb with associated dyspnoea and diaphoresis...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28761627/acute-management-of-stroke-in-iran-obstacles-and-solutions
#17
Shima Shahjouei, Reza Bavarsad-Shahripour, Farhad Assarzadegan, Reza Rikhtegar, Masoud Mehrpour, Babak Zamani, Georgios Tsivgoulis, Andrei Alexandrov, Anne Alexandrov, Ramin Zand
Background: Stroke is among the leading causes of mortality and permanent disability in the world. Iran is located in the stroke belt and has a high age-adjusted stroke incidence rate. In this multistep prospective qualitative study, we aimed at investigating the status and challenges of stroke management in Iran and explore possible solutions. Methods: In the first and second phase, we attempted to define the status of stroke management in Iran by searching the relevant literature and conducting semi-structured interviews with health-care providers in thirteen hospitals located in seven large cities in Iran...
April 4, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28760858/segregation-of-visual-response-properties-in-the-mouse-superior-colliculus-and-their-modulation-during-locomotion
#18
Shinya Ito, David A Feldheim, Alan M Litke
The superior colliculus (SC) receives direct input from the retina and integrates it with information about sound, touch and state of the animal that is relayed from other parts of the brain to initiate specific behavioral outcomes. The superficial SC layers (sSC) contain cells that respond to visual stimuli, while the deep SC layers (dSC) contain cells that also respond to auditory and somatosensory stimuli. Here we used a large-scale silicon probe recording system to examine the visual response properties of SC cells of head-fixed and alert male mice...
July 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28759268/relationship-between-neuropsychological-tests-and-driver-s-licence-renewal-tests-in-parkinson-s-disease
#19
Dolors Badenes, Maite Garolera, Laura Casas, Juan Carlos Cejudo, Silvia Zaragoza, Noemi Calzado, Miquel Aguilar
Objective To determine whether the standard Spanish driving test (ASDE test) was able to identify patients with Parkinson's disease (PD) at risk of unsafe driving, and to examine the relationship between the ASDE test and the UFOV as well as with a battery of neuropsychological tests in PD drivers. Methods Thirty-seven PD patients and 33 controls matched by age and education level were included in an observational study. All participants were active drivers and PD patients underwent study procedures after taking the medication in the "on" period...
July 31, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28756438/feedback-and-training-to-improve-use-of-an-electronic-prescribing-system-a-randomised-controlled-trial
#20
Scott Leung, Wu Yi Zheng, Anmol Sandhu, Richard Day, Ling Li, Melissa Baysari
Excessive presentation of alerts in electronic prescribing systems (ePS) results in 'alert fatigue' which reduces alert effectiveness and frustrates users. Previous research at our study site showed high rates of duplication alerts, some of which were the result of doctors not using available short-cut functions in the ePS. This study aimed to improve uptake of short-cut functions and so reduce alert fatigue by trialing two interventions: feedback and training. Fifty doctors were randomised to one of three groups: Control, Feedback or Training...
2017: Studies in Health Technology and Informatics
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