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calcium channel blocker

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https://www.readbyqxmd.com/read/29913196/pntx2-6-or-%C3%AE-cntx-pn2a-a-toxin-from-phoneutria-nigriventer-spider-venom-releases-l-glutamate-from-rat-brain-synaptosomes-involving-na-and-ca-2-channels-and-changes-protein-expression-at-the-blood-brain-barrier
#1
Carolina Nunes da Silva, Rosângela Silva Lomeo, Fernanda Silva Torres, Marcia Helena Borges, Marta Cordeiro Nascimento, Maria Helena Rodrigues Mesquita-Britto, Catarina Rapôso, Adriano Monteiro de Castro Pimenta, Maria Alice da Cruz-Höfling, Dawidson Assis Gomes, Maria Elena de Lima
PhTx2 is the most toxic fraction from the venom of the spider Phoneutria nigriventer, being responsible to sodium entry into cortical synaptosomes, increasing the release of neurotransmitters, such as l-glutamate (L-Glu) and; acetylcholine. In this study, we investigated the action of a toxin purified from; PhTx2 fraction, called PnTx2-6 or δ-CNTX-Pn2a, on L-Glu release from rat; brain cortex synaptosomes, as well as its ability to induce blood-brain barrier permeability. PnTx2-6 increased L-Glu release from rat cortical brain synaptosomes in a time- and dose-dependent manner (EC50 = ∼20 nM; Tm = 16min), as measured by a fluorimetric method...
June 15, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29908836/dopps-data-suggest-a-possible-survival-benefit-of-renin-angiotensin-aldosterone-system-inhibitors-and-other-antihypertensive-medications-for-hemodialysis-patients
#2
Angelo Karaboyas, Hairong Xu, Hal Morgenstern, Francesco Locatelli, Michel Jadoul, Kosaku Nitta, Indranil Dasgupta, Francesca Tentori, Friedrich K Port, Bruce M Robinson
The benefits of renin angiotensin-aldosterone system inhibitors (RAASi) are well-established in the general population, particularly among those with diabetes, congestive heart failure (CHF), or coronary artery disease (CAD). However, conflicting evidence from trials and concerns about hyperkalemia limit RAASi use in hemodialysis patients, relative to other antihypertensive agents, including beta blockers and calcium channel blockers. Therefore, we investigated prescription patterns and associations with mortality for RAASi and other antihypertensive agents using data from the international Dialysis Outcomes and Practice Patterns Study (DOPPS)...
June 13, 2018: Kidney International
https://www.readbyqxmd.com/read/29908471/searching-for-synergistic-calcium-antagonists-and-novel-therapeutic-regimens-for-coronary-heart-disease-therapy-from-a-traditional-chinese-medicine-suxiao-jiuxin-pill
#3
Wei Lei, Jianan Ni, Xueting Xia, Min Jiang, Gang Bai
Coronary heart disease is a vital cause of morbidity and mortality worldwide, and calcium channel blockers (CCBs) are important drugs that can be used to treat cardiovascular diseases. Suxiao Jiuxin Pill (SX), a traditional Chinese medicine, is widely used as an emergency drug for coronary heart disease therapy. However, understanding its potential mechanism in intracellular calcium concentration ([Ca2+ ]i ) modulation remains a challenge. To identify the active pharmacological ingredients (APIs) and reveal a novel combination therapy for ameliorating cardiovascular diseases, the ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) combined with a dual-luciferase reporter [Ca2+ ]i assay system was applied...
June 8, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29897531/how-relevant-are-the-drug-drug-interactions-between-antiretroviral-boosted-based-regimens-and-calcium-channel-blockers-in-real-life
#4
Dario Cattaneo, Tiziana Formenti, Noemi Astuti, Paola Meraviglia, Annalisa Ridolfo, Cristina Gervasoni
No abstract text is available yet for this article.
April 19, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29893359/correlation-between-sex-and-prognosis-of-acute-aortic-dissection-in-the-chinese-population
#5
Yan-Jie Liu, Xiao-Zeng Wang, Ya Wang, Rui-Xia He, Lin Yang, Quan-Min Jing, Hai-Wei Liu
Background: The prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex. Greater understanding on the differences between men and women with acute aortic dissection (AAD) is needed. We aimed to investigate whether sex disparities are found in patients with AAD, and to study sex differences in complications, mortality in-hospital, and long-term. Methods: We included 884 patients enrolled in our institute between June 2002 and May 2016...
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29892919/resistant-hypertension-in-pregnancy-how-to-manage
#6
REVIEW
Maria Rita Bortolotto, Rossana Pulcineli Vieira Francisco, Marcelo Zugaib
PURPOSE OF REVIEW: The concept of resistant hypertension may be changed during pregnancy by the physiological hemodynamic changes and the particularities of therapy choices in this period. This review discusses the management of pregnant patients with preexisting resistant hypertension and also of those who develop severe hypertension in gestation and puerperium. RECENT FINDINGS: The main cause of severe hypertension in pregnancy is preeclampsia, and differential diagnosis must be done with secondary or primary hypertension...
June 11, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29891858/plasma-mir-142-predicts-major-adverse-cardiovascular-events-as-an-intermediate-biomarker-of-dual-antiplatelet-therapy
#7
Qian-Jie Tang, He-Ping Lei, Hong Wu, Ji-Yan Chen, Chun-Yu Deng, Wang-Sheng Sheng, Yong-Heng Fu, Xiao-Hong Li, Yu-Bi Lin, Ya-Ling Han, Shi-Long Zhong
MicroRNAs (miRNAs) are widely expressed in organisms and are implicated in the regulation of most biological functions. The present study investigated the association of plasma miRNAs with the clinical outcomes of dual antiplatelet therapy in coronary artery disease (CAD) patients who underwent percutaneous coronary intervention (PCI). Plasma miRNA levels were screened using high-throughput Illumina sequencing to evaluate the antiplatelet efficacy of clopidogrel and aspirin. Six plasma miRNAs (miR-126, miR-130a, miR-27a, miR-106a, miR-21, and miR-142) were associated with clopidogrel-treated platelet aggregation...
June 11, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29891648/hypoxia-induced-mitogenic-factor-promotes-cardiac-hypertrophy-via-calcium-dependent-and-hypoxia-inducible-factor-1%C3%AE-mechanisms
#8
Santosh Kumar, Gang Wang, Wenjuan Liu, Wenwen Ding, Ming Dong, Na Zheng, Hongyu Ye, Jie Liu
HIMF (hypoxia-induced mitogenic factor/found in inflammatory zone 1/resistin like α) is a secretory and cytokine-like protein and serves as a critical stimulator of hypoxia-induced pulmonary hypertension. With a role for HIMF in heart disease unknown, we explored the possible roles for HIMF in cardiac hypertrophy by overexpressing and knocking down HIMF in cardiomyocytes and characterizing HIMF gene ( himf ) knockout mice. We found that HIMF mRNA and protein levels were upregulated in phenylephrine-stimulated cardiomyocyte hypertrophy and our mouse model of transverse aortic constriction-induced cardiac hypertrophy, as well as in human hearts with dilated cardiomyopathy...
June 11, 2018: Hypertension
https://www.readbyqxmd.com/read/29890050/diltiazem-improves-contractile-properties-of-skeletal-muscle-in-dysferlin-deficient-blaj-mice-but-does-not-reduce-contraction-induced-muscle-damage
#9
Morium Begam, Alyssa F Collier, Amber L Mueller, Renuka Roche, Sujay S Galen, Joseph A Roche
B6.A-Dysfprmd /GeneJ (BLAJ) mice model human limb-girdle muscular dystrophy 2B (LGMD2B), which is linked to mutations in the dysferlin (DYSF) gene. We tested the hypothesis that, the calcium ion (Ca2+ ) channel blocker diltiazem (DTZ), reduces contraction-induced skeletal muscle damage, in BLAJ mice. We randomly assigned mice (N = 12; 3-4 month old males) to one of two groups - DTZ (N = 6) or vehicle (VEH, distilled water, N = 6). We conditioned mice with either DTZ or VEH for 1 week, after which, their tibialis anterior (TA) muscles were tested for contractile torque and susceptibility to injury from forced eccentric contractions...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29888950/comparison-of-amlodipine-versus-other-calcium-channel-blockers-on-blood-pressure-variability-in-hypertensive-patients-in-china-a-retrospective-propensity-score-matched-analysis
#10
Lin Zhang, JinKui Yang, LanTing Li, DongDong Liu, XiaoPing Xie, Peng Dong, Yong Lin
AIM: Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-established, long-acting calcium channel blocker (CCB). However, few data are available for amlodipine on blood pressure variability (BPV) in China in a real-world setting. This study aimed to assess the effect of amlodipine versus other CCB antihypertensive agents on BPV...
June 11, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29887996/s-amlodipine-an-isomer-with-difference-time-to-shift-from-racemic-amlodipine
#11
REVIEW
Jamshed Dalal, J C Mohan, S S Iyengar, Jagdish Hiremath, Immaneni Sathyamurthy, Sandeep Bansal, Dhiman Kahali, Arup Dasbiswas
Calcium channel blockers are among the first-line drugs for treatment of hypertension (HTN). S-amlodipine (S-AM), an S-enantiomer of amlodipine, is available in India and in other countries like China, Korea, Russia, Ukraine, and Nepal. Being clinically researched for nearly two decades, we performed in-depth review of S-AM. This review discusses clinical evidence from total 42 studies (26 randomized controlled trials, 14 observational studies, and 2 meta-analyses) corroborating over 7400 patients treated with S-AM...
2018: International Journal of Hypertension
https://www.readbyqxmd.com/read/29886423/upward-shift-and-steepening-of-the-blood-pressure-response-to-exercise-in-hypertensive-subjects-at-high-altitude
#12
Sergio Caravita, Andrea Faini, Claudia Baratto, Grzegorz Bilo, Josè Luis Macarlupu, Morin Lang, Miriam Revera, Carolina Lombardi, Francisco C Villafuerte, Piergiuseppe Agostoni, Gianfranco Parati
BACKGROUND: Acute exposure to high-altitude hypobaric hypoxia induces a blood pressure rise in hypertensive humans, both at rest and during exercise. It is unclear whether this phenomenon reflects specific blood pressure hyperreactivity or rather an upward shift of blood pressure levels. We aimed at evaluating the extent and rate of blood pressure rise during exercise in hypertensive subjects acutely exposed to high altitude, and how these alterations can be counterbalanced by antihypertensive treatment...
June 9, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29883554/abscisic-acid-a-novel-uterine-stimulator-in-normal-and-diabetic-rats
#13
Shereen M Samir, Abeer F Mostafa
INTRODUCTION: Diabetes is usually associated with alterations in myometrial contractility with altered oxytocin responsiveness that increase the incidence of fetal and maternal morbidity and mortality. Pancreatic β-cells release abscisic acid (ABA) in response to glucose which in turn potentiates insulin secretion. AIM OF THE STUDY: was to find out the effect of abscisic acid on the uterine contractility in normal and diabetic induced rats and tried to detect its possible underlying signaling pathway...
June 8, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29878067/de-novo-mutation-screening-in-childhood-onset-cerebellar-atrophy-identifies-gain-of-function-mutations-in-the-cacna1g-calcium-channel-gene
#14
Jean Chemin, Karine Siquier-Pernet, Michaël Nicouleau, Giulia Barcia, Ali Ahmad, Daniel Medina-Cano, Sylvain Hanein, Nami Altin, Laurence Hubert, Christine Bole-Feysot, Cécile Fourage, Patrick Nitschké, Julien Thevenon, Marlène Rio, Pierre Blanc, Céline Vidal, Nadia Bahi-Buisson, Isabelle Desguerre, Arnold Munnich, Stanislas Lyonnet, Nathalie Boddaert, Emily Fassi, Marwan Shinawi, Holly Zimmerman, Jeanne Amiel, Laurence Faivre, Laurence Colleaux, Philippe Lory, Vincent Cantagrel
Cerebellar atrophy is a key neuroradiological finding usually associated with cerebellar ataxia and cognitive development defect in children. Unlike the adult forms, early onset cerebellar atrophies are classically described as mostly autosomal recessive conditions and the exact contribution of de novo mutations to this phenotype has not been assessed. In contrast, recent studies pinpoint the high prevalence of pathogenic de novo mutations in other developmental disorders such as intellectual disability, autism spectrum disorders and epilepsy...
June 5, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29877737/clevidipine-as-a-therapeutic-and-cost-effective-alternative-to-sodium-nitroprusside-in-patients-with-acute-aortic-syndromes
#15
Carlos L Alviar, Alejandra Gutierrez, Leslie Cho, Amar Krishnaswamy, Amr Saleh, Michael A Lincoff, Eric Roselli, Michael Militello, Venu Menon
BACKGROUND: Sodium nitroprusside is the preferred agent for the treatment of high blood pressure during acute aortic syndrome if blood pressure remains elevated after heart rate control with beta-blockers. The increasing cost of sodium nitroprusside in the USA led us to assess the efficacy and safety of intravenous clevidipine, a calcium channel blocker with quick onset of action, short half-life and significantly lower costs than sodium nitroprusside, in patients presenting with acute aortic syndrome...
June 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29875965/-prevalence-and-adverse-effects-of-antihypertensive-agents-in-patients-followed-up-on-an-ambulatory-basis-at-the-university-hospital-yalgado-ou%C3%A3-draogo
#16
Georges Rosario Christian Millogo, Ragomzingba Frank Edgard Zongo, Anita Benao, Estelle Noëla Hoho Youl, Blaise Alexandre Bazona Bassoleth, Moussa Ouédraogo, Patrice Zabsonré, Innocent Pierre Guissou
Medicinal treatment of arterial hypertension (AH) may cause adverse effects which can be annoying and thus influence patient's compliance with treatment. Our study focused on these undesirable effects in patients followed up for AH on an ambulatory basis in the Department of Cardiology at the University Hospital Yalgado Ouédraogo from July to September 2015. Our aim was to determine their rates and their characteristics. Data were obtained from patients' interview, from the examination of patients' follow-up records and of medical consultation forms...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29875913/-peculiarities-of-anesthesia-for-the-surgical-treatment-of-pheochromocytoma-about-a-case
#17
Amadou Magagi, Harissou Adamou, Ibrahim Amadou Magagi, Maazou Halidou, Oumarou Habou, Hassane Moussa Diongolé, Maman Sani Rabiou, Mahaman Boukari Baoua
This study decribes the treatment of a 37-year old female patient, with a history of poorly treated arterial hypertension (AH), referred to surgical consultation with right lower back pain, vertigo, headache, sweating and palpitations. During hospitalization, blood pressure (BP) ranged between 130/80 mm Hg and 190/120 mm Hg. The remainder of the clinical examination was normal. Thoracoabdominal scanner showed adrenal mass measuring 55x45x65 mm compressing the inferior vena cava and the right renal vein. The assay of urinary vanilmandelic acid (VMA) was 11...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29874661/treatment-of-angina-where-are-we
#18
Cristina Balla, Rita Pavasini, Roberto Ferrari
Ischaemic heart disease is a major cause of death and disability worldwide, while angina represents its most common symptom. It is estimated that approximately 9 million patients in the USA suffer from angina and its treatment is challenging, thus the strategy to improve the management of chronic stable angina is a priority. Angina might be the result of different pathologies, ranging from the "classical" obstruction of a large coronary artery to alteration of the microcirculation or coronary artery spasm...
June 6, 2018: Cardiology
https://www.readbyqxmd.com/read/29870433/associations-between-relevant-cardiovascular-pharmacotherapies-and-incident-heart-failure-in-patients-with-atrial-fibrillation-a-cohort-study-in-primary-care
#19
Per Wändell, Axel C Carlsson, Martin J Holzmann, Johan Ärnlöv, Jan Sundquist, Kristina Sundquist
OBJECTIVE: To study association between relevant cardiovascular pharmacotherapy and incident congestive heart failure (CHF) in patients with atrial fibrillation treated in primary health care. METHODS: Study population included all adults (n = 7975) aged 45 years and older diagnosed with atrial fibrillation at 75 primary care centers in Sweden between 2001 and 2007. Outcome was defined as a first diagnosis of CHF post-atrial fibrillation diagnosis. Association between CHF and treatment with relevant cardiovascular pharmacotherapies (beta blockers, calcium blockers, digitalis, diuretics, RAS blockers, and statins) was explored using Cox regression analysis with hazard ratios and 95% CIs...
June 4, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29868180/a-case-of-atenolol-induced-sinus-node-dysfunction-presenting-as-escape-capture-bigeminy
#20
Janaki Rami Reddy Manne
Medications that are routinely used in clinical practice to treat hypertension such as beta blockers or non-dihydropyridine calcium channel blockers can depress sinus node function, resulting in symptoms and electrocardiographic changes consistent with sinus node dysfunction. In some patients, medications are potentially a reversible cause of apparent sinus node dysfunction. We report a patient who was taking atenolol for hypertension presented with recurrent near syncopal spells due to atenolol-induced sinus node dysfunction manifested in the form of an interesting and rare arrhythmia known as Escape-capture bigeminy...
May 2018: Oxford Medical Case Reports
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