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Sergio Eduardo Alonso Araujo, Lucas de Araujo Horcel, Victor Edmond Seid, Alexandre Bruno Bertoncini, Sidney Klajner
Background: Stapled hemorrhoidopexy is associated with less postoperative pain and faster recovery. However, it may be associated with a greater risk of symptomatic recurrence. We hypothesized that undertaking a limited surgical excision of hemorrhoid disease after stapling may be a valid approach for selected patients. Aim: To compare long-term results after stapled hemorrhoidopexy with and without complementation with closed excisional technique. Method: In a retrospective uni-institutional cohort study, sixty-five (29 men) patients underwent stapled hemorrhoidopexy and 21 (13 men) underwent stapled hemorrhoidopexy with excision...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Bishoy Kamel, Garry G Graham, Kenneth M Williams, Kevin D Pile, Richard O Day
Febuxostat is a xanthine oxidoreductase inhibitor that has been developed to treat chronic gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral dose administration include an oral availability of about 85 %, an apparent oral clearance (CL/F) of 10.5 ± 3.4 L/h and an apparent volume of distribution at steady state (V ss/F) of 48 ± 23 L. The time course of plasma concentrations follows a two-compartment model. The initial half-life (t ½) is approximately 2 h and the terminal t ½ determined at daily doses of 40 mg or more is 9...
October 17, 2016: Clinical Pharmacokinetics
Xia Zhu-Barker, Shannon K Bailey, Kyaw Tha Paw U, Martin Burger, William R Horwath
The process of composting is a source of greenhouse gases (GHG) that contribute to climate change. We monitored three field-scale green waste compost windrows over a one-year period to measure the seasonal variance of the GHG fluxes. The compost pile that experienced the wettest and coolest weather had the highest average CH4 emission of 254±76gCday(-1) dry weight (DW) Mg(-1) and lowest average N2O emission of 152±21mgNday(-1) DW Mg(-1)compared to the other seasonal piles. The highest N2O emissions (342±41mgNday(-1) DW Mg(-1)) came from the pile that underwent the driest and hottest weather...
October 14, 2016: Waste Management
Antonio López-Orenes, María C Bueso, Héctor M Conesa, Antonio A Calderón, María A Ferrer
Soil pollution by heavy metals/metalloids (HMMs) is a problem worldwide. To prevent dispersion of contaminated particles by erosion, the maintenance of a vegetative cover is needed. Successful plant establishment in multi-polluted soils can be hampered not only by HMM toxicities, but also by soil nutrient deficiencies and the co-occurrence of abiotic stresses. Some plant species are able to thrive under these multi-stress scenarios often linked to marked fluctuations in environmental factors. This study aimed to investigate the metabolic adjustments involved in Zygophyllum fabago acclimative responses to conditions prevailing in HMM-enriched mine-tailings piles, during Mediterranean spring and summer...
October 14, 2016: Science of the Total Environment
Danielle L Duncan, Mark G Carls, Stanley D Rice, Michael S Stekoll
Polycyclic aromatic hydrocarbons (PAHs) from creosote exposure in the laboratory resulted in deleterious effects in developing Pacific herring (Clupea pallasi) embryos and potentially toxic concentrations of PAHs were measured using passive water samplers at one of three harbor field sites in Juneau, Alaska. Aqueous TPAH concentrations of 4.6 and 8.4 µg/L from creosote exposure resulted in skeletal defects and ineffective swimming in hatched larvae in the laboratory (EC10s), and were the most sensitive parameters measured...
October 14, 2016: Environmental Toxicology and Chemistry
Xuefei Tu, Apichaya Aneksampant, Shizusa Kobayashi, Atsushi Tanaka, Ryo Nishimoto, Masami Fukushima
It had been reported that iron and manganese oxides in steel slag enhanced the production of humic acid (HA) from low-molecular-weight compounds, such as phenolic acids, amino acids, and saccharides. In the present study, this function of steel slag was applied to the composting of raw organic wastes (ROWs). The degree of humification of HAs is an important factor in evaluating compost quality. Thus, HAs were extracted from the prepared composts and the humification parameters were determined, in terms of elemental compositions, acidic functional group contents, molecular weights, spectroscopic parameters from UV-vis absorption and (13)C NMR spectra...
October 13, 2016: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Simon P Bach, Nicola S Fearnhead
No abstract text is available yet for this article.
October 7, 2016: Lancet
Chong Hu, Sheng Lin, Wanbo Li, Han Sun, Yangfan Chen, Chiu-Wing Chan, Chung-Hang Leung, Dik-Lung Ma, Hongkai Wu, Kangning Ren
An ultra-fast, extremely cost-effective, and environmentally friendly method was developed for fabricating flexible microfluidic chips with plastic membranes. With this method, we could fabricate plastic microfluidic chips rapidly (within 12 seconds per piece) at an extremely low cost (less than $0.02 per piece). We used a heated perfluoropolymer perfluoroalkoxy (often called Teflon PFA) solid stamp to press a pile of two pieces of plastic membranes, low density polyethylene (LDPE) and polyethylene terephthalate (PET) coated with an ethylene-vinyl acetate copolymer (EVA)...
October 5, 2016: Lab on a Chip
Liam Payne, Peter J Heard, Thomas B Scott
Pile Grade A graphite was used as a moderator and reflector material in the first generation of UK Magnox nuclear power reactors. As all of these reactors are now shut down there is a need to examine the concentration and distribution of long lived radioisotopes, such as 14C, to aid in understanding their behaviour in a geological disposal facility. A selection of irradiated graphite samples from Oldbury reactor one were examined where it was observed that Raman spectroscopy can distinguish between underlying graphite and a surface deposit found on exposed channel wall surfaces...
2016: PloS One
Subramania Kolappan, Mathieu Coureuil, Xiong Yu, Xavier Nassif, Edward H Egelman, Lisa Craig
Neisseria meningitidis use Type IV pili (T4P) to adhere to endothelial cells and breach the blood brain barrier, causing cause fatal meningitis. T4P are multifunctional polymers of the major pilin protein, which share a conserved hydrophobic N terminus that is a curved extended α-helix, α1, in X-ray crystal structures. Here we report a 1.44 Å crystal structure of the N. meningitidis major pilin PilE and a ∼6 Å cryo-electron microscopy reconstruction of the intact pilus, from which we built an atomic model for the filament...
October 4, 2016: Nature Communications
Junya Zhang, Qianwen Sui, Juan Tong, Chulu Buhe, Rui Wang, Meixue Chen, Yuansong Wei
Sewage sludge is considered as one of major contributors to the increased environmental burden of ARGs. Sludge bio-drying was increasingly adopted due to its faster sludge reduction compared with composting. The fate of ARGs during full-scale sludge bio-drying was investigated to determine whether it could effectively reduce ARGs, and the contributions of bacterial community, horizontal gene transfer (HGT) through mobile genetic elements (MGEs) and co-selection from heavy metals to ARGs profiles were discussed in detail...
September 28, 2016: Water Research
Jane Curren, Samantha A Hallis, Cherie Cher L Snyder, Irwin Mel H Suffet
The objective of this study was to evaluate the effectiveness of a modified Odor Profile Method (OPM) at a trash transfer station (TTS). An updated Landfill Odor Wheel was used to define odor character and distinguish among odor sources. The Flavor Profile Analysis (FPA) intensity scale was used to rank the relative intensity of the various odor characters defined by the odor wheel and to understand how each odor profile changed off site. Finally, the odor wheel was used to select the appropriate chemical analysis to identify the odorants causing the odors identified by the human panelists...
September 27, 2016: Waste Management
Arpad Karsai, Teri Jo Slack, Hamed Malekan, Fadi Khoury, Wei-Feng Lin, Victoria Tran, Daniel Cox, Michael Toney, Xi Chen, Gang-Yu Liu
Mucin 1 (MUC1) peptide fused with Q11 (MUC1-Q11) having 35 residues has previously been shown to form amyloid fibrils. Using time-dependent and high-resolution atomic force microscopy (AFM) imaging, it is revealed that the formation of individual MUC1-Q11 fibrils entails nucleation and extension at both ends. This process can be altered by local mechanical perturbations using AFM probes. This work reports two specific perturbations and outcomes. First, by increasing load while maintaining tip-surface contact, the fibrils are cut during the scan due to shearing...
September 30, 2016: Small
Xiaomei Zhou, Catherine J Mondloch
We investigated recognition of familiar and unfamiliar own- and other-race faces across natural variability in appearance. Participants sorted 20 photographs of each of two identities into piles such that each pile contained all photographs of a single identity. The other-race effect was limited to unfamiliar faces. When faces were unfamiliar, participants perceived more identities when sorting other-race races; when faces were familiar, participants made two piles for both own- and other-race faces. Our work calls for rethinking the concept of the other-race effect...
September 28, 2016: Perception
Yu-Lin Su, Kuan-Ting Chen, Yu-Chen Sheu, Shuo-Yuan Sung, Ru-Siou Hsu, Chi-Shiun Chiang, Shang-Hsiu Hu
Delivery of drug and energy within responsive carriers that effectively target and accumulate in cancer cells promises to mitigate side effects and to enhance the uniquely therapeutic efficacy demanded for personalized medicine. To achieve this goal, however, these carriers, which are usually piled up at the periphery of tumors near the blood vessel, must simultaneously overcome the challenges associated with low tumor penetration and the transport of sufficient cargos to deep tumors to eradicate whole cancer cells...
October 3, 2016: ACS Nano
Jonathan S Cant, Yaoda Xu
Our visual system can extract summary statistics from large collections of objects without forming detailed representations of the individual objects in the ensemble. In a region in ventral visual cortex encompassing the collateral sulcus and the parahippocampal gyrus and overlapping extensively with the scene-selective parahippocampal place area (PPA), we have previously reported fMRI adaptation to object ensembles when ensemble statistics repeated, even when local image features differed across images (e...
September 27, 2016: Journal of Cognitive Neuroscience
Zdzisław M Migaszewski, Agnieszka Gałuszka, Sabina Dołęgowska
A detailed hydrogeochemical study was performed in the Wiśniówka mining area (south-central Poland). This covered three acid pit bodies, historic tailings acid ponds, acid pools, and additionally two neighboring rivers. All these acid mine drainage (AMD) waters are characterized by the pH in the range of 1.7 (pools) to 3.5 (tailings ponds). The most interesting is the Podwiśniówka acid pit lake that shows a very low pH (2.2-2.5) and very high concentrations of SO4 (2-) (2720-5460 mg/L), Fe (545-1140 mg/L), Al (86...
September 25, 2016: Environmental Science and Pollution Research International
Ying Yuan, Xiao-Song He, Bei-Dou Xi, Zi-Min Wei, Wen-Bing Tan, Ru-Tai Gao
Vulnerability assessment of simple landfills was conducted using the multimedia, multipathway and multireceptor risk assessment (3MRA) model for the first time in China. The minimum safe threshold of six contaminants (benzene, arsenic (As), cadmium (Cd), hexavalent chromium [Cr(VI)], divalent mercury [Hg(II)] and divalent nickel [Ni(II)]) in landfill and waste pile models were calculated by the 3MRA model. Furthermore, the vulnerability indexes of the six contaminants were predicted based on the model calculation...
November 2016: Waste Management & Research
Satoshi Tsutsumi, Hideo Ono, Yukimasa Yasumoto
PURPOSE: Arachnoid granulations (AGs) occasionally appear to protrude into the calvarial convexity, lying close to the bridging veins (BVs). This study aims to characterize such AGs and BVs using magnetic resonance imaging (MRI). METHODS: Ninety-five patients were enrolled in this study. Initially, stepwise frontal craniotomy was performed in an injected cadaver head. Next, examinations with contrast MRI were performed involving the whole cranial vault. RESULTS: In cadaveric dissection, the AGs located in the parasagittal regions appeared as outward protrusions through the dura mater and in contact with the diploic veins...
September 19, 2016: Surgical and Radiologic Anatomy: SRA
Jing Li, Jin Xie, Fei-Xue Yu, Yu-Hui Chen, Pei-Ji Zhao
The white pine blister rust caused by Cronartium ribicola is a severe disease of Pinus armandii Franch in Sichuan Province, China. A mycoparasite was isolated from aeciospore piles of C. ribicola and identified as Pestalotipsis sp. The chemical constituents were investigated and nine new polyketides, named pestalotic acids A-I (1-9), were isolated from solid fermentation products of Pestalotiopsis sp. cr014. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D- NMR, HR-MS experiments...
September 19, 2016: Archives of Pharmacal Research
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