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https://www.readbyqxmd.com/read/27932317/end-of-life-care-for-infants-children-and-young-people-with-life-limiting-conditions-summary-of-nice-guidance
#1
Gemma Villanueva, M Stephen Murphy, David Vickers, Emily Harrop, Katharina Dworzynski
No abstract text is available yet for this article.
December 8, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27929461/isolation-of-high-density-lipoproteins-for-non-coding-small-rna-quantification
#2
Danielle L Michell, Ryan M Allen, Stuart R Landstreet, Shilin Zhao, Cynthia L Toth, Quanhu Sheng, Kasey C Vickers
The diversity of small non-coding RNAs (sRNA) is rapidly expanding and their roles in biological processes, including gene regulation, are emerging. Most interestingly, sRNAs are also found outside of cells and are stably present in all biological fluids. As such, extracellular sRNAs represent a novel class of disease biomarkers and are likely involved in cell signaling and intercellular communication networks. To assess their potential as biomarkers, sRNAs can be quantified in plasma, urine, and other fluids...
November 28, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27928105/sio2-nanocomposite-film-coating-of-cad-cam-composite-resin-blocks-improves-surface-hardness-and-reduces-susceptibility-to-bacterial-adhesion
#3
Pranithida Kamonwanon, Nanako Hirose, Satoshi Yamaguchi, Jun-Ichi Sasaki, Haruaki Kitagawa, Ranna Kitagawa, Sroisiri Thaweboon, Toemsak Srikhirin, Satoshi Imazato
Composite resin blocks for computer-aided design/computer-aided manufacturing (CAD/CAM) applications have recently become available. However, CAD/CAM composite resins have lower wear resistance and accumulate more plaque than CAD/CAM ceramic materials. We assessed the effects of SiO2-nanocomposite film coating of four types of CAD/CAM composite resin blocks: Cerasmart, Katana Avencia block, Lava Ultimate, and Block HC on surface hardness and bacterial attachment. All composite blocks with coating demonstrated significantly greater Vickers hardness, reduced surface roughness, and greater hydrophobicity than those without coating...
December 6, 2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27927700/cardiac-%C3%AE-v%C3%AE-3-integrin-expression-following-acute-myocardial-infarction-in-humans
#4
William S A Jenkins, Alex T Vesey, Colin Stirrat, Martin Connell, Christophe Lucatelli, Anoushka Neale, Catriona Moles, Anna Vickers, Alison Fletcher, Tania Pawade, Ian Wilson, James H F Rudd, Edwin J R van Beek, Saeed Mirsadraee, Marc R Dweck, David E Newby
OBJECTIVE: Maladaptive repair contributes towards the development of heart failure following myocardial infarction (MI). The αvβ3 integrin receptor is a key mediator and determinant of cardiac repair. We aimed to establish whether αvβ3 integrin expression determines myocardial recovery following MI. METHODS: (18)F-Fluciclatide (a novel αvβ3-selective radiotracer) positron emission tomography (PET) and CT imaging and gadolinium-enhanced MRI (CMR) were performed in 21 patients 2 weeks after ST-segment elevation MI (anterior, n=16; lateral, n=4; inferior, n=1)...
December 7, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27917127/maternal-high-fat-diet-alters-skeletal-muscle-mitochondrial-catalytic-activity-in-adult-male-rat-offspring
#5
Chantal A Pileggi, Christopher P Hedges, Stephanie A Segovia, James F Markworth, Brenan R Durainayagam, Clint Gray, Xiaoyuan D Zhang, Matthew P G Barnett, Mark H Vickers, Anthony J R Hickey, Clare M Reynolds, David Cameron-Smith
A maternal high-fat (HF) diet during pregnancy can lead to metabolic compromise, such as insulin resistance in adult offspring. Skeletal muscle mitochondrial dysfunction is one mechanism contributing to metabolic impairments in insulin resistant states. Therefore, the present study aimed to investigate whether mitochondrial dysfunction is evident in metabolically compromised offspring born to HF-fed dams. Sprague-Dawley dams were randomly assigned to receive a purified control diet (CD; 10% kcal from fat) or a high fat diet (HFD; 45% kcal from fat) for 10 days prior to mating, throughout pregnancy and during lactation...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27899744/decisional-conflict-regret-and-the-burden-of-rational-decision-making
#6
EDITORIAL
Andrew J Vickers
No abstract text is available yet for this article.
January 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/27897215/novel-ti-ta-hf-zr-alloys-with-promising-mechanical-properties-for-prospective-stent-applications
#7
Jixing Lin, Sertan Ozan, Yuncang Li, Dehai Ping, Xian Tong, Guangyu Li, Cuie Wen
Titanium alloys are receiving increasing research interest for the development of metallic stent materials due to their excellent biocompatibility, corrosion resistance, non-magnetism and radiopacity. In this study, a new series of Ti-Ta-Hf-Zr (TTHZ) alloys including Ti-37Ta-26Hf-13Zr, Ti-40Ta-22Hf-11.7Zr and Ti-45Ta-18.4Hf-10Zr (wt.%) were designed using the d-electron theory combined with electron to atom ratio (e/a) and molybdenum equivalence (Moeq) approaches. The microstructure of the TTHZ alloys were investigated using optical microscopy, XRD, SEM and TEM and the mechanical properties were tested using a Vickers micro-indenter, compression and tensile testing machines...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890682/implementation-of-dynamically-updated-prediction-models-at-the-point-of-care-at-a-major-cancer-center-making-nomograms-more-like-netflix
#8
Andrew J Vickers, Mathew Kent, Peter T Scardino
No abstract text is available yet for this article.
November 24, 2016: Urology
https://www.readbyqxmd.com/read/27884193/reorganising-specialist-cancer-surgery-for-the-twenty-first-century-a-mixed-methods-evaluation-respect-21
#9
Naomi J Fulop, Angus I G Ramsay, Cecilia Vindrola-Padros, Michael Aitchison, Ruth J Boaden, Veronica Brinton, Caroline S Clarke, John Hines, Rachael M Hunter, Claire Levermore, Satish B Maddineni, Mariya Melnychuk, Caroline M Moore, Muntzer M Mughal, Catherine Perry, Kathy Pritchard-Jones, David C Shackley, Jonathan Vickers, Stephen Morris
BACKGROUND: There are longstanding recommendations to centralise specialist healthcare services, citing the potential to reduce variations in care and improve patient outcomes. Current activity to centralise specialist cancer surgical services in two areas of England provides an opportunity to study the planning, implementation and outcomes of such changes. London Cancer and Manchester Cancer are centralising specialist surgical pathways for prostate, bladder, renal, and oesophago-gastric cancers, so that these services are provided in fewer hospitals...
November 25, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27881316/effects-of-aqueous-and-acid-based-coloring-liquids-on-the-hardness-of-zirconia-restorations
#10
Ji-Young Nam, Mi-Gyoung Park
STATEMENT OF PROBLEM: The effects of the application of aqueous coloring liquids on the mechanical properties of zirconia have not yet been investigated. PURPOSE: The purpose of this in vitro study was to evaluate the effects of 3 different coloring techniques and the number of coloring liquid applications on the hardness of zirconia. MATERIAL AND METHODS: Eighty specimens were divided into 8 groups (n=10); nonshaded zirconia, preshaded zirconia, acid-based coloring liquid zirconia, and aqueous coloring liquid zirconia (1, 3, 6)...
October 27, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27871220/quiet-eye-training-aids-the-long-term-learning-of-throwing-and-catching-in-children-preliminary-evidence-for-a-predictive-control-strategy
#11
C A L Miles, G Wood, S J Vine, J N Vickers, M R Wilson
Quiet eye training (QET) may be a more effective method for teaching children to catch than traditional training (TT) methods, but it is unclear if the benefits accrued persist in the long term. Thirty children were randomly allocated into a QET or TT group and, while wearing a mobile eye tracker, underwent baseline testing, training and two retention tests over a period of eight weeks, using a validated throw and catch task. During training, movement-related information was provided to both groups, while the QET group received additional instruction to increase the duration of their targeting fixation (QE1) on the wall prior to the throw, and pursuit tracking (QE2) period on the ball prior to catching...
February 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/27867109/towards-long-lasting-zirconia-based-composites-for-dental-implants-transformation-induced-plasticity-and-its-consequence-on-ceramic-reliability
#12
Helen Reveron, Marta Fornabaio, Paola Palmero, Tobias Fürderer, Erik Adolfsson, Vanni Lughi, Alois Bonifacio, Valter Sergo, Laura Montanaro, Jérôme Chevalier
: Zirconia-based composites were developed through an innovative processing route able to tune compositional and microstructural features very precisely. Fully-dense ceria-stabilized zirconia ceramics (84vol% Ce-TZP) containing equiaxed alumina (8vol%Al2O3) and elongated strontium hexa-aluminate (8vol% SrAl12O19) second phases were obtained by conventional sintering. This work deals with the effect of the zirconia stabilization degree (CeO2 in the range 10.0-11.5mol%) on the transformability and mechanical properties of Ce-TZP-Al2O3-SrAl12O19 materials...
November 17, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27860240/bespoke-design-of-whole-cell-microbial-machines
#13
Claudia Vickers
No abstract text is available yet for this article.
November 17, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27858979/spatial-variation-in-mandibular-bone-elastic-modulus-and-its-effect-on-structural-bending-stiffness-a-test-case-using-the-ta%C3%A3-forest-monkeys
#14
Kim N Le, Matthew Marsik, David J Daegling, Ana Duque, William Scott McGraw
OBJECTIVES: We investigated how heterogeneity in material stiffness affects structural stiffness in the cercopithecid mandibular cortical bone. We assessed (1) whether this effect changes the interpretation of interspecific structural stiffness variation across four primate species, (2) whether the heterogeneity is random, and (3) whether heterogeneity mitigates bending stress in the jaw associated with food processing. MATERIALS AND METHODS: The sample consisted of Taï Forest, Cote d'Ivoire, monkeys: Cercocebus atys, Piliocolobus badius, Colobus polykomos, and Cercopithecus diana...
November 18, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27849012/liquid-supercoolability-and-synthesis-kinetics-of-quinary-refractory-high-entropy-alloy
#15
W L Wang, L Hu, S J Yang, A Wang, L Wang, B Wei
The high-entropy configuration of equiatomic multicomponent alloys opens an effective access to the development of advanced materials. Here we report the synthesis of a new quinary refractory WMoTaNbZr high-entropy alloy under electrostatic levitation condition. It showed a high liquidus temperature of 2686 K and achieved a maximum supercooling of 640 K (0.24 TL) at molten state. The containerless measurements revealed a linear increasing tendency for both its liquid state density and the specific heat to emissivity ratio versus alloy supercooling...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27845927/first-principles-phase-diagram-calculations-for-the-rocksalt-structure-quasibinary-systems-tin-zrn-tin-hfn-and-zrn-hfn
#16
Z T Y Liu, B P Burton, S V Khare, D Gall
We have studied the phase equilibria of three ceramic quasibinary systems Ti1-x Zr x N, Ti1-x Hf x N and Zr1-x Hf x N (0  ⩽  x  ⩽  1) with density functional theory, cluster expansion and Monte Carlo simulations. We predict consolute temperatures (T C), at which miscibility gaps close, for Ti1-x Zr x N to be 1400 K, for Ti1-x Hf x N to be 700 K, and below 200 K for Zr1-x Hf x N. The asymmetry of the formation energy ΔE f(x) is greater for Ti1-x Hf x N than Ti1-x Zr x N, with less solubility on the smaller cation TiN-side, and similar asymmetries were predicted for the corresponding phase diagrams...
November 15, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27843971/cold-burn-injuries-in-the-uk-the-11-year-experience-of-a-tertiary-burns-centre
#17
Metin Nizamoglu, Alethea Tan, Tobias Vickers, Nicholas Segaren, David Barnes, Peter Dziewulski
BACKGROUND: Guidance for the management of thermal injuries has evolved with improved understanding of burn pathophysiology. Guidance for the management of cold burn injuries is not widely available. The management of these burns differs from the standard management of thermal injuries. This study aimed to review the etiology and management of all cold burns presenting to a large regional burn centre in the UK and to provide a simplified management pathway for cold burns. METHODS: An 11-year retrospective  analysis (1 January 2003-31 December 2014)  of all cold injuries presenting to a regional burns centre in the UK was conducted...
2016: Burns and trauma
https://www.readbyqxmd.com/read/27836814/own-brand-label-restorative-materials-a-false-bargain
#18
Gaute Floer Johnsen, Minh Khai Le Thieu, Badra Hussain, Elzbieta Pamuła, Janne Elin Reseland, Ståle Petter Lyngstadaas, Håvard Haugen
OBJECTIVES: This study aims at evaluating and comparing mechanical, chemical, and cytotoxicological parameters of a commercial brand name composite material against two 'own brand label' (OBL) composites. METHODS: Parameters included depth of cure, flexural strength, degree of conversion, polymerization shrinkage, filler particle morphology and elemental analyzes, Vickers hardness, surface roughness parameters after abrasion, monomer elution, and cytotoxicity. RESULTS: The conventional composite outperformed the OBLS in terms of depth of cure (p<0...
November 9, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27836147/effect-of-artificial-toothbrushing-and-water-storage-on-the-surface-roughness-and-micromechanical-properties-of-tooth-colored-cad-cam-materials
#19
Simon Flury, Elisabeth Diebold, Anne Peutzfeldt, Adrian Lussi
STATEMENT OF PROBLEM: Because of the different composition of resin-ceramic computer-aided design and computer-aided manufacturing (CAD-CAM) materials, their polishability and their micromechanical properties vary. Moreover, depending on the composition of the materials, their surface roughness and micromechanical properties are likely to change with time. PURPOSE: The purpose of this in vitro study was to investigate the effect of artificial toothbrushing and water storage on the surface roughness (Ra and Rz) and the micromechanical properties, surface hardness (Vickers [VHN]) and indentation modulus (EIT), of 5 different tooth-colored CAD-CAM materials when polished with 2 different polishing systems...
November 14, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27826818/a-qualitative-study-of-motivations-for-minority-recruitment-in-cancer-clinical-trials-across-five-nci-designated-cancer-centers
#20
Zachary R Simoni, Michelle Martin, Jennifer A Wenzel, Elise D Cook, Badrinath Konety, Selwyn M Vickers, Moon S Chen, Mona N Foaud, Raegan W Durant
BACKGROUND: Minority enrollment in cancer clinical trials is traditionally low. In light of this fact, numerous studies have investigated barriers to recruitment and retention within minority populations. However, very little research has investigated the importance of clinicians' and researchers' motivations for minority recruitment in cancer clinical trials. Therefore, we sought to examine motivations for minority recruitment across four professional stakeholder groups (principal investigators, clinicians, research staff, and Cancer Center leaders) at five National Cancer Institute (NCI)-designated Comprehensive Cancer Centers...
November 8, 2016: Journal of Racial and Ethnic Health Disparities
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