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Shutan Liao, Mark H Vickers, Rennae S Taylor, Beatrix Jones, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
OBJECTIVE: To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by later preeclampsia (PE). STUDY DESIGN: In a nested case-control study, PE cases (n=71) and matched controls (n=71) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20weeks of gestation were determined by ELISA...
October 2017: Pregnancy Hypertension
Jung-Hsuan Chen, Yen-Chen Shen, Chuen-Guang Chao, Tzeng-Feng Liu
Mg-5wt.% Sn alloy is often used in portable electronic devices and automobiles. In this study, mechanical properties of Mg-5wt.% Sn alloy processed by Equal Channel Angular Extrusion (ECAE) were characterized. More precisely, its hardness and wear behavior were measured using Vickers hardness test and a pin-on-disc wear test. The microstructures of ECAE-processed Mg-Sn alloys were investigated by scanning electron microscope and X-ray diffraction. ECAE process refined the grain sizes of the Mg-Sn alloy from 117...
November 16, 2017: Materials
Farah Z Zia, Oluwadamilola Olaku, Ting Bao, Ann Berger, Gary Deng, Arthur Yin Fan, Mary K Garcia, Patricia M Herman, Ted J Kaptchuk, Elena J Ladas, Helene M Langevin, Lixing Lao, Weidong Lu, Vitaly Napadow, Richard C Niemtzow, Andrew J Vickers, Xin Shelley Wang, Claudia M Witt, Jun J Mao
The Division of Cancer Treatment and Diagnosis, Office of Cancer Complementary and Alternative Medicine, at the National Cancer Institute (NCI) held a symposium on "Acupuncture for Cancer Symptom Management" on June 16 and 17, 2016. Invited speakers included 19 scientists and scholars with expertise in acupuncture and cancer research from the United States, Europe, and China. The conference reviewed the NCI's grant funding on acupuncture, analyzed the needs of cancer patients, reviewed safety issues, and assessed both the current scientific evidence and research gaps of acupuncture in oncology care...
November 1, 2017: Journal of the National Cancer Institute. Monographs
Melissa Assel, Liisa Sjöblom, Teemu J Murtola, Kirsi Talala, Paula Kujala, Ulf-Håkan Stenman, Kimmo Taari, Anssi Auvinen, Andrew Vickers, Tapio Visakorpi, Teuvo L Tammela, Hans Lilja
BACKGROUND: A panel of four kallikrein markers (total, free, and intact prostate-specific antigen [PSA] and human kallikrein-related peptidase 2 [hK2]) improves predictive accuracy for Gleason score ≥7 (high-grade) prostate cancer among men biopsied for elevated PSA. A four-kallikrein panel model was originally developed and validated by the Dutch center of the European Randomized Study of Screening for Prostate Cancer (ERSPC). The kallikrein panel is now commercially available as 4Kscore™...
November 11, 2017: European Urology Focus
Samantha Le Sommer, Nicola Morrice, Martina Pesaresi, Dawn Thompson, Mark A Vickers, Graeme I Murray, Nimesh Mody, Benjamin G Neel, Kendra K Bence, Heather M Wilson, Mirela Delibegovic
Protein tyrosine phosphatase PTP1B is a critical regulator of signaling pathways controlling metabolic homeostasis, cell proliferation and immunity. In this study, we report that global or myeloid-specific deficiency of PTP1B in mice decreases lifespan. We demonstrate that myeloid-specific deficiency of PTP1B is sufficient to promote the development of acute myeloid leukemia (AML). LysM-PTP1B-/- mice lacking PTP1B in the innate myeloid cell lineage displayed a dysregulation of bone marrow cells with a rapid decline in population at midlife and a concomitant increase in peripheral blood blast cells...
November 9, 2017: Cancer Research
Hugh MacPherson, Emily Ann Vertosick, Andrew Julian Vickers
No abstract text is available yet for this article.
December 2017: Pain
Dorothea Helmer, Nico Keller, Frederik Kotz, Friederike Stolz, Christian Greiner, Tobias M Nargang, Kai Sachsenheimer, Bastian E Rapp
Superhydrophobic surfaces and surface coatings are of high interest for many applications in everyday life including non-wetting and low-friction coatings as well as functional clothing. Manufacturing of these surfaces is intricate since superhydrophobicity requires structuring of surfaces on a nano- to microscale. This delicate surface structuring makes most superhydrophobic surfaces very sensitive to abrasion and renders them impractical for real-life applications. In this paper we present a transparent fluorinated polymer foam that is synthesized by a simple one-step photoinitiated radical polymerization...
November 8, 2017: Scientific Reports
Katarina Kelić, Sanja Matić, Danijela Marović, Eva Klarić, Zrinka Tarle
The aim of the study was to determine microhardness of high- and low-viscosity bulk-fill composite resins and compare it with conventional composite materials. Four materials of high-viscosity were tested, including three bulk-fills: QuiXfi l (QF), x-tra fi l (XTF) and Tetric EvoCeram Bulk Fill (TEBCF), while nanohybrid composite GrandioSO (GSO) served as control. The other four were low-viscosity composites, three bulk-fill materials: Smart Dentin Replacement (SDR), Venus Bulk Fill (VBF) and x-tra base (XB), and conventional control material X-Flow (XF)...
December 2016: Acta Clinica Croatica
Zahra Khamverdi, Matin Kordestani, Ali Reza Soltanian
Objectives: The aim of this study was to evaluate the effect of dentin remineralization using proanthocyanidin (PA), fluoride varnish and casein phosphopeptide amorphous calcium phosphate (CPP-ACP) paste and their various combinations on microhardness of demineralized root dentin. Materials and Methods: One-hundred and twenty freshly extracted sound human premolars were selected and randomly divided into eight groups for dentin treatment as follows. C: Deionized water (control); PA: 6...
March 2017: Journal of Dentistry of Tehran University of Medical Sciences
Negin Nasoohi, Maryam Hoorizad, Seyedeh Farnaz Tabatabaei
Objectives: This study aimed to assess the effect of wet and dry finishing and polishing on microhardness and roughness of microhybrid and nanohybrid composites. Materials and Methods: Thirty samples were fabricated of each of the Polofil Supra and Aelite Aesthetic All-Purpose Body microhybrid and Grandio and Aelite Aesthetic Enamel nanohybrid composite resins. Each group (n=30) was divided into three subgroups of D, W and C (n=10). Finishing and polishing were performed dry in group D and under water coolant in group W...
March 2017: Journal of Dentistry of Tehran University of Medical Sciences
Deepesh Prajapati, Rashmi Nayak, Deepika Pai, Nagraj Upadhya, Vipin K Bhaskar, Pujan Kamath
Aim: To evaluate the effectiveness of resin infiltration on artificial caries lesion by assessing the depth of resin penetration and the change in microhardness of lesion postinfiltration. Materials and methods: Totally 45 human extracted premolars were used to create an artificial demineralized lesion in enamel using demineralizing solution. A total of 15 samples (group I) were infiltrated with resin. The depth of resin penetration was studied using scanning electron microscope (SEM)...
July 2017: International Journal of Clinical Pediatric Dentistry
Kenta Yamanaka, Manami Mori, Yasuhiro Torita, Akihiko Chiba
The effect of nitrogen concentration on the mechanical properties of Co-33Cr-9W alloy dental castings fabricated using the "high-Cr and high-N" concept was investigated. Microstructural analysis was performed on the alloys, and findings were discussed in relation to the mechanical properties. Owing to their high nitrogen concentrations (0.25-0.35wt%), all alloys prepared exhibited face-centered cubic (fcc) γ-phase matrices with a-few-millimeter grains consisting of dendritic substructures. Strain-induced martensitic transformations to produce hexagonal close-packed (hcp) ε-phases were not identified under tensile deformation...
October 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
Qiaoqiao Zhuang, Peilei Zhang, Mingchuan Li, Hua Yan, Zhishui Yu, Qinghua Lu
The Ni-Ti-Si composite coatings were successfully fabricated on Ti6Al4V by laser cladding. The microstructure were studied by SEM (scanning electron microscopy) and EDS (energy dispersive spectrometer). It has been found that Ti₂Ni and Ti₅Si₃ phases exist in all coatings, and some samples have TiSi₂ phases. Moreover, due to the existence of these phases, coatings presented relatively higher microhardness than that of the substrate (826 HV (Vickers hardness)) and the microhardness value of coating 3 is about twice larger than that of the substrate...
October 30, 2017: Materials
Qiting Huang, Wei Qin, Sufyan Garoushi, Jingwei He, Zhengmei Lin, Fang Liu, Pekka K Vallittu, Lippo V J Lassila
The objective of this study was to investigate several physicochemical properties of an experimental discontinuous S2-glass fiberreinforced resin composite. The experimental composite was prepared by mixing 10 wt% of discontinuous S2-glass fibers with 27.5 wt% of resin matrix and 62.5 wt% of particulate fillers. Flexural strength (FS) and modulus (FM), fracture toughness (FT), work of fracture (WOF), double bond conversion (DC), Vickers hardness, volume shrinkage (VS) and fiber length distribution were determined...
October 27, 2017: Dental Materials Journal
Farahnaz Sharafeddin, Mahsa Kowkabi, Soodabe Shoale
BACKGROUND: Home bleaching agents may exert some negative effects on surface hardness of restorative materials such as glass-ionomer cements (GICs). Since some studies have shown that some components such as hydroxyapatite (HA), as a bioactive glass, can improve the mechanical properties of dental materials, the effect of bleaching agents on surface hardness of GICs containing hydroxyapatite is questionable. This study was designed to evaluate the effect of home bleaching agents on the surface hardness of two different commercially available GICs containing hydroxyapatite...
September 2017: Journal of Clinical and Experimental Dentistry
R M Ahmedbeyli
The aim of the study was to evaluate the efficacy of dental caries prevention program with 3 years follow-up in children living in areas with fluoride and iodine deficiency. The study involved 625 school-aged children aged 6, 12 and 15 years receiving endogenous prevention with fluoridated and iodinated salt (300±50 mgF/kg and 40±10 mgI/kg). Enamel and dentine concentrations of CA, P, F and I were measured in 98 intact deciduous teeth by X-ray microanalysis before and after prevention program. Enamel and dentin microhardness was assessed in the same 98 teeth by Vickers Hardness Test...
2017: Stomatologii︠a︡
Ladan Ranjbar Omrani, Sara Khoshamad, Elham Tabatabaei Ghomshe, Nasim Chiniforush, Sedighe Sadat Hashemi Kamangar
Introduction: This study sought to assess the effect of bleaching combined with irradiation of 810 nm and 980 nm diode laser on microhardness of 2 commonly used self-cure and light-cure glass ionomer cements (GICs) in comparison with conventional bleaching (without laser). Methods: In this in vitro, experimental study, 60 samples were fabricated of A2 shade of Fuji IX and Fuji II LC GICs (n=30) and each group was divided into 3 subgroups (n=10). The first subgroups were subjected to bleaching with Opalescence Xtra Boost plus 980 nm diode laser irradiation...
2017: Journal of Lasers in Medical Sciences
Viviane Maria Gonçalves de Figueiredo, Sarina Maciel Braga Pereira, Eduardo Bressiani, Márcia Carneiro Valera, Marco Antônio Bottino, Yu Zhang, Renata Marques de Melo
OBJECTIVE: This study evaluated the influence of porcelain (VM9, VITA Zahnfabrik, Germany) thickness on the flexural strength and crack propagation in bilayered zirconia systems (YZ, VITA Zahnfabrik, Germany). MATERIAL AND METHODS: Thirty zirconia bars (20.0x4.0x1.0 mm) and six zirconia blocks (12.0x7.5x1.2 mm) were prepared and veneered with porcelain with different thickness: 1 mm, 2 mm, or 3 mm. The bars of each experimental group (n=10) were subjected to four-point flexural strength testing...
September 2017: Journal of Applied Oral Science: Revista FOB
David D Ward, Ross Andel, Nichole L Saunders, Megan E Thow, Shannon Z Klekociuk, Aidan D Bindoff, James C Vickers
INTRODUCTION: Cognitive reserve (CR) and BDNF Val66Met are independently associated with the rate of cognitive decline in preclinical Alzheimer's disease. This study was designed to investigate the interactive effects of these variables on 36-month cognitive change in cognitively intact older adults. METHODS: Data for this investigation were obtained from 445 community-residing participants of the Tasmanian Healthy Brain Project, who underwent genetic screening and annual assessment of neuropsychological, health, and psychosocial function...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Carmen M Fernandez-Martos, Rachel A K Atkinson, Meng I Chuah, Anna E King, James C Vickers
INTRODUCTION: Combination therapy approaches may be necessary to address the many facets of pathologic change in the brain in Alzheimer's disease (AD). The drugs leptin and pioglitazone have previously been shown individually to have neuroprotective and anti-inflammatory actions, respectively, in animal models. METHODS: We studied the impact of combined leptin and pioglitazone treatment in 6-month-old APP/PS1 (APPswe/PSEN1dE9) transgenic AD mouse model. RESULTS: We report that an acute 2-week treatment with combined leptin and pioglitazone resulted in a reduction of spatial memory deficits (Y maze) and brain β-amyloid levels (soluble β-amyloid and amyloid plaque burden) relative to vehicle-treated animals...
January 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
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