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https://www.readbyqxmd.com/read/28343461/the-impact-of-maternal-obesity-on-inflammatory-processes-and-consequences-for-later-offspring-health-outcomes
#1
S A Segovia, M H Vickers, C M Reynolds
Obesity is a global epidemic, affecting both developed and developing countries. The related metabolic consequences that arise from being overweight or obese are a paramount global health concern, and represent a significant burden on healthcare systems. Furthermore, being overweight or obese during pregnancy increases the risk of offspring developing obesity and other related metabolic complications in later life, which can therefore perpetuate a transgenerational cycle of obesity. Obesity is associated with a chronic state of low-grade metabolic inflammation...
March 27, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28342935/interpreting-patient-reported-urinary-and-sexual-function-outcomes-across-multiple-validated-instruments
#2
Emily A Vertosick, Andrew J Vickers, Janet E Cowan, Jeanette M Broering, Peter R Carroll, Matthew R Cooperberg
INTRODUCTION: Comparing patient-reported outcomes such as urinary and erectile function across institutions is critical for prostate cancer research and quality assurance. Such comparisons are complicated by the use of different questionnaires. We aimed to develop a method to convert scores between four commonly used instruments. MATERIALS AND METHODS: Patient-reported data on urinary and sexual function were collected from 1,284 men with localized prostate cancer using the Expanded Prostate Index Composite (EPIC-26), UCLA Prostate Cancer Index (PCI), Sexual Health Inventory for Men (SHIM) and International Prostate Symptom Scale (IPSS) questionnaires...
March 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28338021/absence-of-a-gestational-diabetes-phenotype-in-the-leprdb-mouse-is-independent-of-control-strain-diet-misty-allele-or-parity
#3
Jasmine F Plows, XinYang Yu, Ric Broadhurst, Mark H Vickers, Chao Tong, Hua Zhang, HongBo Qi, Joanna L Stanley, Philip N Baker
Treatment options for gestational diabetes (GDM) are limited. In order to better understand mechanisms and improve treatments, appropriate animal models of GDM are crucial. Heterozygous db mice (db/+) present with glucose intolerance, insulin resistance, and increased weight gain during, but not prior to, pregnancy. This makes them an ideal model for GDM. However, several recent studies have reported an absence of GDM phenotype in their colony. We investigated several hypotheses for why the phenotype may be absent, with the aim of re-establishing it and preventing further resources being wasted on an ineffective model...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28333399/evaluation-of-surface-roughness-characteristics-using-atomic-force-microscopy-and-inspection-of-microhardness-following-resin-infiltration-with-icon-%C3%A2
#4
Elif Beril Gurdogan, Didem Ozdemir-Ozenen, Nuket Sandalli
OBJECTIVE: The aim of this study was to evaluate the surface roughness via atomic force microscopy (AFM) as well as to evaluate the microhardness values of Icon(®) in comparison with sound and demineralized enamel in a large subject group. MATERIALS AND METHODS: Enamel samples were prepared from sound bovine incisors and randomly allocated into either AFM (n = 60) or microhardness (n = 60) groups. The AFM group was divided into control (n = 30) and Icon(®) (n = 30) subgroups...
March 23, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28333319/wck-4234-a-novel-diazabicyclooctane-potentiating-carbapenems-against-enterobacteriaceae-pseudomonas-and-acinetobacter-with-class-a-c-and-d-%C3%AE-lactamases
#5
Shazad Mushtaq, Anna Vickers, Neil Woodford, David M Livermore
Background: Several diazabicyclooctanes (DBOs) are under development as inhibitors of class A and C β-lactamases. Inhibition of OXA (class D) carbapenemases is variable, with those of Acinetobacter spp. remaining notably resistant. We describe a novel DBO, WCK 4234 (Wockhardt), with distinctive activity against OXA carbapenemases. Methods: MICs of imipenem and meropenem were determined by CLSI agar dilution with WCK 4234 added at 4 or 8 mg/L. Test organisms were clinical Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa with carbapenemases or carbapenem resistance via porin loss plus AmpC or ESBL activity...
February 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28328215/synthesis-and-mechanical-character-of-hexagonal-phase-%C3%AE-wn
#6
Changchun Wang, Qiang Tao, Shushan Dong, Xin Wang, Pinwen Zhu
In this work, high-quality bulk WC-structured WN (δ-WN) was synthesized via an untraditional method and the structure was accurately determined by X-ray diffraction and Rietveld refinement. In the process of synthesizing δ-WN, W2N3 and melamine were used as tungsten source and nitrogen source, respectively. The result of successfully synthesized high-quality δ-WN indicates that our method is an effective route for synthesizing high-quality bulk δ-WN and melamine is a pure nitrogen source for introducing the nitrogen to the metal precursor...
March 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28320490/effect-of-cu-on-nanoscale-precipitation-evolution-and-mechanical-properties-of-a-fe-nial-alloy
#7
Qin Shen, Hao Chen, Wenqing Liu
The microstructural evolution of precipitation in two model alloys, Fe-NiAl and Fe-NiAl-Cu, was investigated during aging at 500°C for different times using atom probe tomography (APT). The APT results reveal that the addition of Cu effectively increases the number density of NiAl precipitates. This is attributed to Cu promoting the nucleation of NiAl particles by increasing the chemical driving force and decreasing the interfacial energy. The NiAl precipitates of the Fe-NiAl-Cu alloy grow and coarsen at a slower rate than that of the Fe-NiAl alloy, mainly due to the slower diffusion rate of the Cu atoms...
March 21, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28314357/experimental-study-on-thermal-conductivity-and-hardness-of-cu-and-ni-nanoparticle-packed-bed-for-thermoelectric-application
#8
Zi-Zhen Lin, Cong-Liang Huang, Wen-Kai Zhen, Yan-Hui Feng, Xin-Xin Zhang, Ge Wang
The hot-wire method is applied in this paper to probe the thermal conductivity (TC) of Cu and Ni nanoparticle packed beds (NPBs). A different decrease tendency of TC versus porosity than that currently known is discovered. The relationship between the porosity and nanostructure is investigated to explain this unusual phenomenon. It is found that the porosity dominates the TC of the NPB in large porosities, while the TC depends on the contact area between nanoparticles in small porosities. Meanwhile, the Vickers hardness (HV) of NPBs is also measured...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28295104/wb2-not-a-superhard-material-for-strong-polarization-character-of-interlayer-w-b-bonding
#9
Changchun Wang, Qiang Tao, Shuailing Ma, Tian Cui, Xin Wang, Shushan Dong, Pinwen Zhu
In this work, the structure of WB2 synthesized at high pressure and high temperature (HPHT) was accurately determined by X-ray diffraction and Rietveld refinement. Its asymptotic Vickers hardness (Hv) value is 25.5 GPa which is much lower than the previous theoretical results (36-40 GPa). It is worth noting that the chemical bonds between the W layers and two different kinds of B layers show obvious polarization character based on the results obtained from X-ray photoelectron spectroscopy (XPS) and electron localization functions (ELFs), density of states (DOS), topological analysis of the static electron density and Mulliken population...
March 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28294936/examining-the-feasibility-of-implementing-behavioural-economics-strategies-that-encourage-home-dinner-vegetable-intake-among-low-income-children
#10
Tashara M Leak, Alison Swenson, Aaron Rendahl, Zata Vickers, Elton Mykerezi, Joseph P Redden, Traci Mann, Marla Reicks
OBJECTIVE: To examine the feasibility of implementing nine behavioural economics-informed strategies, or 'nudges', that aimed to encourage home dinner vegetable intake among low-income children. DESIGN: Caregivers were assigned six of nine strategies and implemented one new strategy per week (i.e. 6 weeks) during three dinner meals. Caregivers recorded child dinner vegetable intake on the nights of strategy implementation and rated the level of difficulty for assigned strategies...
March 15, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28288296/effect-of-cpp-acp-or-a-potassium-nitrate-sodium-fluoride-dentifrice-on-enamel-erosion-prevention
#11
F I Zawaideh, A I Owais, S Mushtaha
AIM: To investigate in situ/ex vivo the effect of remineralizing agents in the prevention of dental erosion in permanent and primary teeth. STUDY DESIGN: A randomized, controlled, double-blind study with crossover design with three treatment phases: Control, ProNamel(®) and Tooth Mousse(™). Twenty adults and children wore removable palatal appliances containing two insets of permanent and primary human enamel and used the corresponding assigned toothpaste twice daily for 10 days...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28285075/thermally-triggered-hydrogel-injection-into-bovine-intervertebral-disc-tissue-explants-induces-differentiation-of-mesenchymal-stem-cells-and-restores-mechanical-function
#12
A A Thorpe, G Dougill, L Vickers, N D Reeves, C Sammon, G Cooper, C L Le Maitre
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6 weeks...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28273132/re-conceptualizing-stress-shifting-views-on-the-consequences-of-stress-and-its-effects-on-stress-reactivity
#13
Jenny J W Liu, Kristin Vickers, Maureen Reed, Marilyn Hadad
BACKGROUND: The consequences of stress are typically regarded from a deficit-oriented approach, conceptualizing stress to be entirely negative in its outcomes. This approach is unbalanced, and may further hinder individuals from engaging in adaptive coping. In the current study, we explored whether negative views and beliefs regarding stress interacted with a stress framing manipulation (positive, neutral and negative) on measures of stress reactivity for both psychosocial and physiological stressors...
2017: PloS One
https://www.readbyqxmd.com/read/28272341/liver-effects-of-clinical-drugs-differentiated-in-human-liver-slices
#14
Alison E M Vickers, Anatoly V Ulyanov, Robyn L Fisher
Drugs with clinical adverse effects are compared in an ex vivo 3-dimensional multi-cellular human liver slice model. Functional markers of oxidative stress and mitochondrial function, glutathione GSH and ATP levels, were affected by acetaminophen (APAP, 1 mM), diclofenac (DCF, 1 mM) and etomoxir (ETM, 100 μM). Drugs targeting mitochondria more than GSH were dantrolene (DTL, 10 μM) and cyclosporin A (CSA, 10 μM), while GSH was affected more than ATP by methimazole (MMI, 500 μM), terbinafine (TBF, 100 μM), and carbamazepine (CBZ 100 μM)...
March 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28267751/cost-effectiveness-of-adjunct-non-pharmacological-interventions-for-osteoarthritis-of-the-knee
#15
Beth Woods, Andrea Manca, Helen Weatherly, Pedro Saramago, Eleftherios Sideris, Christina Giannopoulou, Stephen Rice, Mark Corbett, Andrew Vickers, Matthew Bowes, Hugh MacPherson, Mark Sculpher
BACKGROUND: There is limited information on the costs and benefits of alternative adjunct non-pharmacological treatments for knee osteoarthritis and little guidance on which should be prioritised for commissioning within the NHS. This study estimates the costs and benefits of acupuncture, braces, heat treatment, insoles, interferential therapy, laser/light therapy, manual therapy, neuromuscular electrical stimulation, pulsed electrical stimulation, pulsed electromagnetic fields, static magnets and transcutaneous electrical nerve Stimulation (TENS), based on all relevant data, to facilitate a more complete assessment of value...
2017: PloS One
https://www.readbyqxmd.com/read/28266297/surgical-treatment-of-a-rare-reverse-madelung-deformity-in-11-years-female-patient
#16
Alexandru Ulici, Daniel Catalin Florea, Iulia Tevanov, Dan Zaharie, Madalina Carp
Madelung deformity is an abnormality of the distal part of the forearm due to a growth arrest in the distal radial physis creating an increase of the radial tilt angle associated with a dorsal subluxation of the distal ulna in most cases. It is a rare condition which represents only 1.7% of hand deformities being characterized by the presence of an abnormal structure, Vickers ligament, that tethers the distal radius to the lunate bone. Although it is believed to be a congenital disorder, the symptoms are absent till late childhood...
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28262805/manganese-mono-boride-an-inexpensive-room-temperature-ferromagnetic-hard-material
#17
Shuailing Ma, Kuo Bao, Qiang Tao, Pinwen Zhu, Teng Ma, Bo Liu, Yazhou Liu, Tian Cui
We synthesized orthorhombic FeB-type MnB (space group: Pnma) with high pressure and high temperature method. MnB is a promising soft magnetic material, which is ferromagnetic with Curie temperature as high as 546.3 K, and high magnetization value up to 155.5 emu/g, and comparatively low coercive field. The strong room temperature ferromagnetic properties stem from the positive exchange-correlation between manganese atoms and the large number of unpaired Mn 3d electrons. The asymptotic Vickers hardness (AVH) is 15...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260947/the-effect-of-curing-intensity-on-mechanical-properties-of-different-bulk-fill-composite-resins
#18
Fahad I Alkhudhairy
OBJECTIVE: The purpose of this study was to investigate the effects of two curing light intensities on the mechanical properties (Vickers microhardness, compressive strength, and diametral tensile strength) of bulk-fill resin-based composites (RBCs). MATERIALS AND METHODS: Four commercially available bulk-fill RBCs (Tetric(®) N-Ceram, SonicFill™, Smart Dentin Replacement (SDR™) Posterior Flowable Material, and Filtek™ Posterior Restorative) were used in this study...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/28248351/extended-depth-of-field-microscopy-with-a-high-speed-deformable-mirror
#19
William J Shain, Nicholas A Vickers, Bennett B Goldberg, Thomas Bifano, Jerome Mertz
We present a wide-field fluorescence microscopy add-on that provides a fast, light-efficient extended depth-of-field (EDOF) using a deformable mirror with an update rate of 20 kHz. Out-of-focus contributions in the raw EDOF images are suppressed with a deconvolution algorithm derived directly from the microscope 3D optical transfer function. Demonstrations of the benefits of EDOF microscopy are shown with GCaMP-labeled mouse brain tissue.
March 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28244996/cellular-uptake-and-trafficking-of-antisense-oligonucleotides
#20
Stanley T Crooke, Shiyu Wang, Timothy A Vickers, Wen Shen, Xue-Hai Liang
Antisense oligonucleotides (ASOs) modified with phosphorothioate (PS) linkages and different 2' modifications can be used either as drugs (e.g., to treat homozygous familial hypercholesterolemia and spinal muscular atrophy) or as research tools to alter gene expression. PS-ASOs can enter cells without additional modification or formulation and can be designed to mediate sequence-specific cleavage of different types of RNA (including mRNA and non-coding RNA) targeted by endogenous RNase H1. Although PS-ASOs function in both the cytoplasm and nucleus, localization to different subcellular regions can affect their therapeutic potency...
March 2017: Nature Biotechnology
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