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https://www.readbyqxmd.com/read/29331949/bibliometric-analysis-of-military-trauma-publications-2000-2016
#1
Mark L Vickers, C P Coorey, G J Milinovich, L Eriksson, M Assoum, M C Reade
INTRODUCTION: Bibliometric tools can be used to identify the authors, topics and research institutions that have made the greatest impact in a field of medicine. The aim of this research was to analyse military trauma publications over the last 16 years of armed conflict in order to highlight the most important lessons that have translated into civilian practice and military doctrine as well as identify emerging areas of importance. METHODS: A systematic search of research published between January 2000 and December 2016 was conducted using the Thompson Reuters Web of Science database...
January 13, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29329659/discovery-of-mcl-1-inhibitors-based-on-a-thiazolidine-2-4-dione-scaffold
#2
Ellis Whiting, Mithun R Raje, Jay Chauhan, Paul T Wilder, Daniel Van Eker, Samuel J Hughes, Nathan G Bowen, Gregory E A Vickers, Ian C Fenimore, Steven Fletcher
Inspired by a rhodanine-based dual inhibitor of Bcl-xL and Mcl-1, a focused library of analogues was prepared wherein the rhodanine core was replaced with a less promiscuous thiazolidine-2,4-dione scaffold. Compounds were initially evaluated for their abilities to inhibit Mcl-1. The most potent compound 12b inhibited Mcl-1 with a Ki of 155 nM. Further investigation revealed comparable inhibition of Bcl-xL (Ki = 90 nM), indicating that the dual inhibitory profile of the initial rhodanine lead had been retained upon switching the heterocycle core...
December 12, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29326199/genome-sequences-of-four-cluster-p-mycobacteriophages
#3
Erin L Doyle, Christy L Fillman, Nathan S Reyna, Deborah M Tobiason, Daniel E Westholm, Jonathan L Askins, Brittany P Backus, Ashlynn C Baker, Harrison S Ballard, Paul J Bisesi, Logan Bond, Deanna Byrnes, Hannah Carlstedt, Kinnon S Dodson, Megan J Fallert, Kyla J Foster, Daniel N Games, Tristan R Grams, Nancy A Guild, Autumn Hurd, Nicholas Iwata, Cassidy R Kepler, Lucinda R Krenzke, Kelly Luekens, Jackie Lewis, Cali McEntee, Justin C McGee, Noah Nalley, Ruth C Plymale, Jade Prochaska, Reid G Rogers, Jessica B Schipper, Kelsey Snyder, Kali Uhrich, Chelsey D Vermillion, Sarah K Vickers, Meredyth D Wenta, Tyler Z Yates, Chas F Young, Ty H Stoner, Welkin H Pope, Deborah Jacobs-Sera, Rebecca A Garlena, Daniel A Russell, Steven G Cresawn, Graham F Hatfull
Four bacteriophages infecting Mycobacterium smegmatis mc2155 (three belonging to subcluster P1 and one belonging to subcluster P2) were isolated from soil and sequenced. All four phages are similar in the left arm of their genomes, but the P2 phage differs in the right arm. All four genomes contain features of temperate phages.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29321010/evaluation-of-five-cad-cam-materials-by-microstructural-characterization-and-mechanical-tests-a-comparative-in-vitro-study
#4
Nesrin Sonmez, Pinar Gultekin, Volkan Turp, Gokhan Akgungor, Deniz Sen, Eitan Mijiritsky
BACKGROUND: Polymer infiltrated ceramics and nano-ceramic resins are the new restorative materials which have been developed in order to enhance the adverse properties of glass-matrix ceramics and resin composites. The aim of the present in vitro study was to evaluate the characteristics of various CAD/CAM materials through mechanical, microstructural, and SEM analysis. METHODS: Five test groups (n = 22) were formed by using the indicated CAD/CAM blocks: VITA Enamic (VITA Zahnfabrik), Lava Ultimate (3 M ESPE), IPS e...
January 8, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29303753/the-effect-of-home-bleaching-carbamide-peroxide-concentration-on-the-microhardness-of-dental-composite-resins
#5
Behnaz Esmaeili, Faezeh Abolghasemzadeh, Atefeh Gholampor, Ghazaleh Daryakenari
Bleaching is a conservative treatment for discolored teeth, but the effect of this treatment on newer, silorane-based composite resins is unclear. This study evaluated the effect of at-home bleaching on the microhardness of methacrylate- and silorane-based composites. Forty blocks each of a methacrylate-based composite and a silorane-based composite were prepared. The 80 specimens were tested in 8 groups (n = 10): 2 composites, each exposed to 3 different carbamide peroxide concentrations (10%, 16%, or 22%) as well as distilled water (control)...
January 2018: General Dentistry
https://www.readbyqxmd.com/read/29301143/prostate-specific-antigen-velocity-in-a-prospective-prostate-cancer-screening-study-of-men-with-genetic-predisposition
#6
Christos Mikropoulos, Christina G Hutten Selkirk, Sibel Saya, Elizabeth Bancroft, Emily Vertosick, Tokhir Dadaev, Charles Brendler, Elizabeth Page, Alexander Dias, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Karol Axcrona, Kate Richardson, Diana Eccles, Thomas Jensen, Palle J Osther, Christi J van Asperen, Hans Vasen, Lambertus A Kiemeney, Janneke Ringelberg, Cezary Cybulski, Dominika Wokolorczyk, Rachel Hart, Wayne Glover, Jimmy Lam, Louise Taylor, Monica Salinas, Lidia Feliubadaló, Rogier Oldenburg, Ruben Cremers, Gerald Verhaegh, Wendy A van Zelst-Stams, Jan C Oosterwijk, Jackie Cook, Derek J Rosario, Saundra S Buys, Tom Conner, Susan Domchek, Jacquelyn Powers, Margreet Gem Ausems, Manuel R Teixeira, Sofia Maia, Louise Izatt, Rita Schmutzler, Kerstin Rhiem, William D Foulkes, Talia Boshari, Rosemarie Davidson, Marielle Ruijs, Apollonia Tjm Helderman-van den Enden, Lesley Andrews, Lisa Walker, Katie Snape, Alex Henderson, Irene Jobson, Geoffrey J Lindeman, Annelie Liljegren, Marion Harris, Muriel A Adank, Judy Kirk, Amy Taylor, Rachel Susman, Rakefet Chen-Shtoyerman, Nicholas Pachter, Allan Spigelman, Lucy Side, Janez Zgajnar, Josefina Mora, Carole Brewer, Neus Gadea, Angela F Brady, David Gallagher, Theo van Os, Alan Donaldson, Vigdis Stefansdottir, Julian Barwell, Paul A James, Declan Murphy, Eitan Friedman, Nicola Nicolai, Lynn Greenhalgh, Elias Obeid, Vedang Murthy, Lucia Copakova, John McGrath, Soo-Hwang Teo, Sara Strom, Karin Kast, Daniel A Leongamornlert, Anthony Chamberlain, Jenny Pope, Anna C Newlin, Neil Aaronson, Audrey Ardern-Jones, Chris Bangma, Elena Castro, David Dearnaley, Jorunn Eyfjord, Alison Falconer, Christopher S Foster, Henrik Gronberg, Freddie C Hamdy, Oskar Johannsson, Vincent Khoo, Jan Lubinski, Eli Marie Grindedal, Joanne McKinley, Kylie Shackleton, Anita V Mitra, Clare Moynihan, Gad Rennert, Mohnish Suri, Karen Tricker, Sue Moss, Zsofia Kote-Jarai, Andrew Vickers, Hans Lilja, Brian T Helfand, Rosalind A Eeles
BACKGROUND: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. METHODS: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values...
January 4, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29301066/an-expanded-heterologous-i-gal-i-promoter-collection-for-diauxie-inducible-expression-in-saccharomyces-cerevisiae
#7
Bingyin Peng, Rebecca J Wood, Lars K Nielsen, Claudia E Vickers
The <i>GAL</i> promoters are applied in metabolic engineering and synthetic biology to control gene expression in the budding yeast <i>Saccharomyces cerevisiae</i>. In <i>gal80Δ</i> background strains, they show diauxie-inducible expression, a feature beneficial in metabolic pathway optimization. However, only a limited number of the <i>GAL</i> promoters have been characterized and are available for engineering purposes. Multiple use of the same promoters can result in genetic instability in engineered strains due to homologous recombination...
January 4, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29290911/gastric-endoscopic-submucosal-dissection-as-a-treatment-for-early-neoplasia-and-for-accurate-staging-of-early-cancers-in-a-united-kingdom-caucasian-population
#8
Aisha Sooltangos, Matthew Davenport, Stephen McGrath, Jonathan Vickers, Siba Senapati, Kurshid Akhtar, Regi George, Yeng Ang
AIM: To investigate the efficacy of endoscopic submucosal dissection (ESD) at diagnosing and treating superficial neoplastic lesions of the stomach in a United Kingdom Caucasian population. METHODS: Data of patients treated with or considered for ESD at a tertiary referral center in the United Kingdom were retrieved for a period of 2 years (May 2015 to June 2017) from the electronic patient records of the hospital. Only Caucasian patients were included. Primary outcomes were curative resection (CR) and were defined as ESD resections with clear horizontal and vertical margin and an absence of lympho-vascular invasion, poor differentiation and submucosal involvement on histological evaluation of the resected specimen...
December 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29279547/characterization-of-fluoride-releasing-restorative-dental-materials
#9
Sufyan Garoushi, Pekka K Vallittu, Lippo Lassila
This study aimed to evaluate and compare certain mechanical properties, Vickers-hardness, water sorption, fluoride-release, shrinkage-stress and wear of five commercial fluoride-releasing restorative materials (Dyract, CompGlass, BEAUTIFIL II, ACTIVARestorative, and GC Fuji II LC), in relation to their microstructural characteristics. Mechanical properties were determined for each material following ISO standards. A wear test was conducted with 15,000 chewing cycles using a dual-axis chewing simulator. Daily fluoride-release was measured during the first 10 days by using a fluoride ion selective electrode...
December 27, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29278514/maternal-serum-placental-growth-hormone-insulin-like-growth-factors-and-their-binding-proteins-at-20-weeks-gestation-in-pregnancies-complicated-by-gestational-diabetes-mellitus
#10
Shutan Liao, Mark H Vickers, Rennae S Taylor, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
OBJECTIVE: To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by gestational diabetes mellitus (GDM). METHOD: In a nested case-control study, GDM cases (n=28) and matched controls (n=28) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20 weeks of gestation were determined by enzyme-linked immunosorbent assay (ELISA)...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278415/towards-industrial-production-of-isoprenoids-in-escherichia-coli-lessons-learned-from-crispr-cas9-based-optimization-of-a-chromosomally-integrated-mevalonate-pathway
#11
Jorge Alonso-Gutierrez, Daisuke Koma, Qijun Hu, Yuchen Yang, Leanne Jade G Chan, Christopher J Petzold, Paul D Adams, Claudia E Vickers, Lars K Nielsen, Jay D Keasling, Taek Soon Lee
Escherichia coli has been the organism of choice for the production of different chemicals by engineering native and heterologous pathways. In the present study, we simultaneously address some of the main issues associated with E. coli as an industrial platform for isoprenoids, including an inability to grow on sucrose, a lack of endogenous control over toxic mevalonate (MVA) pathway intermediates, and the limited pathway engineering into the chromosome. As a proof of concept, we generated an E. coli DH1 strain able to produce the isoprenoid bisabolene from sucrose by integrating the cscAKB operon into the chromosome and by expressing a heterologous MVA pathway under stress-responsive control...
December 26, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29278355/novel-magnesium-elektron21-aln-nanocomposites-produced-by-ultrasound-assisted-casting-microstructure-thermal-and-electrical-conductivity
#12
Abdollah Saboori, Elisa Padovano, Matteo Pavese, Claudio Badini
In the current work, a novel magnesium alloy Elektron21 reinforced by ceramic AlN nanoparticles were produced by an ultrasound-assisted casting. The fabricated nanocomposites were investigated to evaluate their microstructure, hardness, physical, thermal and electrical conductivity. The microstructural evolutions show that a uniform dispersion of the ceramic particles within the matrix can be achieved by employing the ultrasound-assisted stirring. However, some nanoparticles were found to be pushed by the solidification front...
December 26, 2017: Materials
https://www.readbyqxmd.com/read/29259364/effect-of-protective-coating-on-microhardness-of-a-new-glass-ionomer-cement-nanofilled-coating-versus-unfilled-resin
#13
Foad Faraji, Haleh Heshmat, Sepideh Banava
Background and Objectives: EQUIATM is a new gastrointestinal (GI) system with high compressive strength, surface microhardness (MH), and fluoride release potential. This in vitro study aimed to assess the effect of aging and type of protective coating on the MH of EQUIATM GI cement. Materials and Methods: A total of 30 disc-shaped specimens measuring 9 mm in diameter and 2 mm in thickness were fabricated of EQUIATM GI and divided into three groups of G-Coat nanofilled coating (a), no coating (b) and margin bond (c)...
July 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29259015/inactivation-of-cancer-associated-fibroblasts-caf-disrupts-oncogenic-signaling-in-pancreatic-cancer-cells-and-promotes-its-regression
#14
Patricia Dauer, Xianda Zhao, Vineet K Gupta, Nikita S Sharma, Kousik Kesh, Prisca Gnamlin, Vikas Dudeja, Selwyn M Vickers, Sulagna Banerjee, Ashok Saluja
Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) which stimulate oncogenic signaling in TEC. In this study, we evaluated the crosstalk between CAF and TEC isolated from tumors generated in a mouse model of KRAS/mutp53-induced pancreatic cancer (KPC mice). Transcriptomic profiling conducted after treatment with the anticancer compound Minnelide revealed deregulation of the TGF-β signaling pathway in CAF, resulting in an apparent reversal of their activated state to a quiescent, non-proliferative state...
December 19, 2017: Cancer Research
https://www.readbyqxmd.com/read/29242140/positive-impacts-of-a-vegetable-cooking-skills-program-among-low-income-parents-and-children
#15
Francine Overcash, Allison Ritter, Traci Mann, Elton Mykerezi, Joseph Redden, Aaron Rendahl, Zata Vickers, Marla Reicks
OBJECTIVE: To evaluate the impact of a vegetable-focused cooking skills and nutrition program on parent and child psychosocial measures, vegetable liking, variety, and home availability. DESIGN: Baseline and postcourse surveys collected 1-week after the course. SETTING: Low-income communities in Minneapolis-St Paul. PARTICIPANTS: Parent-child dyads (n = 89; one third each Hispanic, African American, and white) with complete pre-post course data; flyer and e-mail recruitment...
December 12, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29239621/a-qualitative-analysis-of-gabapentin-misuse-and-diversion-among-people-who-use-drugs-in-appalachian-kentucky
#16
Rachel Vickers Smith, Elaine M Boland, April M Young, Michelle R Lofwall, Alexa Quiroz, Michele Staton, Jennifer R Havens
Gabapentin, an anticonvulsant and analgesic for postherpetic neuralgia, has been thought to have no abuse potential despite numerous published reports to the contrary. Gabapentin has been linked with impaired driving and opioid use, highlighting the need to more fully understand its risk profile. Thirty-three individuals reporting recent nonmedical use of gabapentin were recruited from two ongoing longitudinal studies of drug users in Appalachian Kentucky to participate in focus groups. Four sessions were held (two in the community and two in jail settings), during which participants responded to questions regarding their personal experiences with gabapentin misuse...
December 14, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29235386/how-is-palliative-care-understood-in-the-context-of-dementia-results-from-a-massive-open-online-course
#17
Fran McInerney, Kathleen Doherty, Aidan Bindoff, Andrew Robinson, James Vickers
BACKGROUND: A palliative approach to the care of people with dementia has been advocated, albeit from an emergent evidence base. The person-centred philosophy of palliative care resonates with the often lengthy trajectory and heavy symptom burden of this terminal condition. AIM: To explore participants' understanding of the concept of palliative care in the context of dementia. The participant population took an online course in dementia. DESIGN: The participant population took a massive open online course on 'Understanding Dementia' and posted answers to the question: 'palliative care means …' We extracted these postings and analysed them via the dual methods of topic modelling analysis and thematic analysis...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29231939/a-first-principles-study-of-the-structural-mechanical-and-electronic-properties-of-precipitates-of-al2cu-in-al-cu-alloys
#18
Y F Ouyang, H M Chen, X M Tao, F Gao, Q Peng, Y Du
The properties of precipitates are important in understanding the strengthening mechanism via precipitation during heat treatment and the aging process in Al-Cu based alloys, where the formation of precipitates is sensitive to temperature and pressure. Here we report a first-principles investigation of the effect of temperature and pressure on the structural stability, elastic constants and formation free energy for precipitates of Al2Cu, as well as their mechanical properties. Based on the formation enthalpy of Guinier-Preston (GP(I)) zones, the size of the GP(I) zone is predicted to be about 1...
December 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29225644/physical-and-chemical-properties-of-cem-cement-mixed-with-propylene-glycol
#19
Fereshte Sobhnamayan, Alireza Adl, Nooshin Sadat Shojaee, Zahra Zarei, Atiyeh Emkani
Introduction: the aim of the present study was to evaluate the influence of propylene glycol (PG) on the flowability, microhardness, pH and calcium ion release of calcium-enriched mixture (CEM). Methods and Materials: CEM cement was mixed with different proportions of PG, as follows: group 1,100% CEM liquid (CL); group 2, 100% PG; group 3, 50% PG and group 4, 20% PG. For assessment of flowability, methodology of ADA Specification No. 57 was applied. For measuring microhardness, 80 cylindrical molds (6×4 mm) were filled with CEM cement and divided into 2 subgroups (4, 21 days) and tested using Vickers Test...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29224379/just-in-time-consent-the-ethical-case-for-an-alternative-to-traditional-informed-consent-in-randomized-trials-comparing-an-experimental-intervention-with-usual-care
#20
Andrew J Vickers, Danny A Young-Afat, Behfar Ehdaie, Scott Yh Kim
Informed consent for randomized trials often causes significant and persistent anxiety, distress and confusion to patients. Where an experimental treatment is compared to a standard care control, much of this burden is potentially avoidable in the control group. We propose a "just-in-time" consent in which consent discussions take place in two stages: an initial consent to research from all participants and a later specific consent to randomized treatment only from those assigned to the experimental intervention...
December 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
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