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https://www.readbyqxmd.com/read/29785170/cost-effectiveness-of-olaratumab-in-combination-with-doxorubicin-for-patients-with-soft-tissue-sarcoma-in-the-united-states
#1
Santiago Zuluaga-Sanchez, Lisa M Hess, Sorrel E Wolowacz, Yulia D'yachkova, Emma Hawe, Adrian D Vickers, James A Kaye, David Bertwistle
Background: Standard first-line treatments for advanced soft tissue sarcoma (STS) have changed little for 40 years, and outcomes have been poor. Recently, the United States (US) Food and Drug Administration conditionally approved olaratumab in combination with doxorubicin (Olara + Dox) based on a randomized phase II trial that reported a significant 11.8-month improvement in median survival versus single-agent doxorubicin (Dox). The present study investigated the cost-effectiveness of Olara + Dox compared with Dox and five other standard-of-care regimens from the US payer perspective...
2018: Sarcoma
https://www.readbyqxmd.com/read/29784190/randomized-trial-comparing-open-radical-cystectomy-and-robot-assisted-laparoscopic-radical-cystectomy-oncologic-outcomes
#2
Bernard H Bochner, Guido Dalbagni, Karim H Marzouk, Daniel D Sjoberg, Justin Lee, Sheri M Donat, Jonathan A Coleman, Andrew Vickers, Harry W Herr, Vincent P Laudone
BACKGROUND: Open radical cystectomy (ORC) has proven to be an important component in the treatment of high-risk bladder cancer (BCa). ORC surgical morbidity remains high; therefore, minimally invasive surgical techniques have been introduced in an attempt to improve patient outcomes. OBJECTIVE: To compare cancer outcomes in BCa patients managed with ORC or robotic-assisted radical cystectomy (RARC). DESIGN, SETTING, AND PARTICIPANTS: A prospective, randomized trial was completed between 2010 and 2013...
May 18, 2018: European Urology
https://www.readbyqxmd.com/read/29780733/the-effect-of-expiration-date-on-mechanical-properties-of-resin-composites
#3
Joseph Sabbagh, Fidele Nabbout, Edgard Jabbour, Gaetane Leloup
Objective: The aim of this in vitro study is to evaluate the effect of expiration date on some mechanical properties of resin composites after controlled storage of syringes and compules in a refrigerator at 4°C. Materials and Methods: Specimens were tested at 7 days after storage in distilled water at room temperature. The investigated properties are the static modulus of elasticity, the flexural strength, and the Vickers microhardness. Same batches of restorative materials were examined at baseline (at least 1 year before their expiration date) and 1 year after they expired...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29780246/remineralization-potential-of-nano-hydroxyapatite-on-enamel-and-cementum-surrounding-margin-of-computer-aided-design-and-computer-aided-manufacturing-ceramic-restoration
#4
Niwut Juntavee, Apa Juntavee, Preeyarat Plongniras
Objective: This study investigates the effects of nano-hydroxyapatite (NHA) gel and Clinpro (CP) on remineralization potential of enamel and cementum at the cavosurface area of computer-aided design and computer-aided manufacturing ceramic restoration. Materials and methods: Thirty extracted human mandibular third molars were sectioned at 1 mm above and below the cemento-enamel junction to remove the cemento-enamel junction portions and replaced them with zirconia ceramic disks by bonding them to the crown and root portions with resin cement...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29778349/a-contemporary-prostate-biopsy-risk-calculator-based-on-multiple-heterogeneous-cohorts
#5
Donna P Ankerst, Johanna Straubinger, Katharina Selig, Lourdes Guerrios, Amanda De Hoedt, Javier Hernandez, Michael A Liss, Robin J Leach, Stephen J Freedland, Michael W Kattan, Robert Nam, Alexander Haese, Francesco Montorsi, Stephen A Boorjian, Matthew R Cooperberg, Cedric Poyet, Emily Vertosick, Andrew J Vickers
BACKGROUND: Prostate cancer prediction tools provide quantitative guidance for doctor-patient decision-making regarding biopsy. The widely used online Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) utilized data from the 1990s based on six-core biopsies and outdated grading systems. OBJECTIVE: We prospectively gathered data from men undergoing prostate biopsy in multiple diverse North American and European institutions participating in the Prostate Biopsy Collaborative Group (PBCG) in order to build a state-of-the-art risk prediction tool...
May 16, 2018: European Urology
https://www.readbyqxmd.com/read/29777736/edge-strength-of-cad-cam-materials
#6
Maria Pfeilschifter, Verena Preis, Michael Behr, Martin Rosentritt
OBJECTIVES: To investigate the edge force of CAD/CAM materials as a function of (a) material, (b) thickness, and (c) distance from the margin. METHODS: Materials intended for processing with CAD/CAM were investigated: eight resin composites, one resin-infiltrated ceramic, and a clinically proven lithiumdisilicate ceramic (reference). To measure edge force (that is, load to failure/crack), plates (d = 1 mm) were fixed and loaded with a Vickers diamond indenter (1 mm/min, Zwick 1446) at a distance of 0...
May 16, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29777311/sufficiency-of-curing-in-high-viscosity-bulk-fill-resin-composites-with-enhanced-opacity
#7
Nicoleta Ilie
OBJECTIVES: The study aims analyzing if improved opacity in modern high-viscosity bulk-fill resin composites (BF-RBC) contradicts with the sufficiency of curing and to assess material's tolerance to less ideal curing conditions. MATERIALS AND METHODS: Simulated large cavities (10 × 6) mm were filled in one increment with three BF-RBCs (Filtek One, FO; Tetric Evo Ceram Bulk Fill, TEC-BF; SonicFill2, SF2). One central and two peripheral (4 mm apart from the center) micromechanical property line-profiles (HV, Vickers hardness; YHU , indentation modulus) were measured in 0...
May 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29771685/enterotoxigenic-escherichia-coli-blood-group-a-interactions-intensify-diarrheal-severity
#8
Pardeep Kumar, F Matthew Kuhlmann, Subhra Chakroborty, A Louis Bourgeois, Jennifer Foulke-Abel, Brunda Tumala, Tim J Vickers, David A Sack, Barbara DeNearing, Clayton D Harro, W Shea Wright, Jeffrey C Gildersleeve, Matthew A Ciorba, Srikanth Santhanam, Chad K Porter, Ramiro L Gutierrez, Michael G Prouty, Mark S Riddle, Alexander Polino, Alaullah Sheikh, Mark Donowitz, James M Fleckenstein
Enterotoxigenic Escherichia coli (ETEC) infections are highly prevalent in developing countries where clinical presentations range from asymptomatic colonization to severe cholera-like illness. The molecular basis for these varied presentations, that may involve strain-specific virulence features as well as host factors, have not been elucidated. We demonstrate that when challenged with ETEC strain H10407, originally isolated from a case of cholera-like illness, blood group A human volunteers developed severe diarrhea more frequently than individuals from other blood groups...
May 17, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29768522/tif4-varnish-protects-the-retention-of-brackets-to-enamel-after-in-vitro-mild-erosive-challenge
#9
Maria Isabel Dantas de Medeiros, Hugo Lemes Carlo, Rogério Lacerda Dos Santos, Frederico Barbosa Sousa, Ricardo Dias de Castro, Renata Cristina Sobreira França, Fabíola Galbiatti de Carvalho
The effect of fluoride agents on the retention of orthodontic brackets to enamel under erosive challenge is little investigated. The aim of this study was to evaluate the effect of titanium tetrafluoride (TiF4) and sodium fluoride (NaF) agents on the shear bond strength of brackets to enamel and on the enamel microhardness around brackets under erosive challenge. Brackets were bonded to bovine incisors. Five groups were formed according to fluoride application (n=10): TiF4 varnish, TiF4 solution, NaF varnish, NaF solution and control (without application)...
May 14, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29765905/the-effect-of-thermocycling-on-the-degree-of-conversion-and-mechanical-properties-of-a-microhybrid-dental-resin-composite
#10
Mehrsima Ghavami-Lahiji, Melika Firouzmanesh, Hossein Bagheri, Tahereh S Jafarzadeh Kashi, Fateme Razazpour, Marjan Behroozibakhsh
Objective: The purpose of this study was to investigate the degree of conversion (DC) and mechanical properties of a microhybrid Filtek Z250 (3M ESPE) resin composite after aging. Method: The specimens were fabricated using circular molds to investigate Vickers microhardness (Vickers hardness number [VHN]) and DC, and were prepared according to ISO 4049 for flexural strength testing. The initial DC (%) of discs was recorded using attenuated total reflectance-Fourier transforming infrared spectroscopy...
May 2018: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29763971/evaluation-of-the-effects-of-the-solution-used-for-electrochemical-dissolution-of-nickel-titanium-endodontic-files-on-dentine-structure-microhardness-and-cell-viability
#11
C C F Amaral, F Ormiga, L C Boldrini, P G Miranda, T A Mendonça, J M Granjeiro, J A C P Gomes
AIM: To evaluate the effects of the [NaF 12 g/L + NaCl 1 g/L] solution used in the electrochemical dissolution process of fractured endodontic files, as well as its NiTi-containing product, on dentine hardness, topography and human fibroblast viability. METHODOLOGY: Sixty single-rooted human teeth were evaluated for dentine microhardness using the Vickers hardness test and the area and number of dentinal tubules by scanning electron microscopy. The samples were divided according to the dentine surface treatment: distilled water; 17% EDTA; [NaF 12 g/L + NaCl 1 g/L]; and 17% EDTA + [NaF 12 g/L + NaCl 1 g/L]...
May 15, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29759831/sustaining-and-disruptive-innovation-in-clinical-electrophysiology-the-subcutaneous-implantable-cardioverter-defibrillator-in-the-young
#12
EDITORIAL
Elizabeth Vickers Saarel
No abstract text is available yet for this article.
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29755658/combined-linkage-and-association-analysis-of-classical-hodgkin-lymphoma
#13
Alastair Lawrie, Shuo Han, Amit Sud, Fay Hosking, Timothee Cezard, David Turner, Caroline Clark, Graeme I Murray, Dominic J Culligan, Richard S Houlston, Mark A Vickers
The heritability of classical Hodgkin lymphoma (cHL) has yet to be fully deciphered. We report a family with five members diagnosed with nodular sclerosis cHL. Genetic analysis of the family provided evidence of linkage at chromosomes 2q35-37, 3p14-22 and 21q22, with logarithm of odds score >2. We excluded the possibility of common genetic variation influencing cHL risk at regions of linkage, by analysing GWAS data from 2,201 cHL cases and 12,460 controls. Whole exome sequencing of affected family members identified the shared missense mutations p...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29746449/effects-of-ceramic-density-and-sintering-temperature-on-the-mechanical-properties-of-a-novel-polymer-infiltrated-ceramic-network-zirconia-dental-restorative-filling-material
#14
Weiyan Li, Jian Sun
BACKGROUND Polymer-infiltrated ceramic-network (PICN) dental material is a new and practical development in orthodontics. Sintering is the process of forming a stable solid mass from a powder by heating without melting. The aim of this study was to evaluate the effects of sintering temperature on the mechanical properties of a PICN zirconia dental material. MATERIAL AND METHODS A dense zirconia ceramic and four PICN zirconia dental materials, with varying porosities, were sintered at three different temperatures; 12 PICN zirconia dental materials based on these porous ceramics were prepared, as well as a pure polymer...
May 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29745262/the-role-of-adolescents-from-a-low-socioeconomic-background-in-household-food-preparation-a-qualitative-study
#15
Tashara M Leak, Taylor A Aasand, Zata Vickers, Marla Reicks
The purpose of this study was to understand adolescents' from low-income households perceptions of their involvement in home food preparation, reasons underlying the extent to which they were involved, and positive and negative consequences associated with their involvement. Semistructured interviews were conducted with a convenience sample of 19 adolescents (13-18 years). Audio-recorded interviews were transcribed verbatim. Themes were identified using grounded theory and the constant comparative method. Eight adolescents described cooking as a primary responsibility due to adult work and family schedules, age, gender, and/or cultural expectations...
May 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29732880/design-of-a-vertical-composite-thin-film-system-with-ultralow-leakage-to-yield-large-converse-magnetoelectric-effect
#16
Rui Wu, Ahmed Kursumovic, Xingyao Gao, Chao Yun, Mary E Vickers, Haiyan Wang, Seungho Cho, Judith L MacManus-Driscoll
Electric field control of magnetism is a critical future technology for low-power, ultrahigh density memory. However, despite intensive research efforts, no practical material systems have emerged. Interface-coupled, composite systems containing ferroelectric and ferri-/ferromagnetic elements have been widely explored, but they have a range of problems, for example, substrate clamping, large leakage, and inability to miniaturize. In this work, through careful material selection, design, and nanoengineering, a high-performance room-temperature magnetoelectric system is demonstrated...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29725881/a-multicentre-open-label-phase-ii-study-of-irinotecan-capecitabine-xeloda%C3%A2-and-oxaliplatin-ixo-as-first-line-treatment-in-patients-with-metastatic-gastric-or-gastroesophageal-junction-gej-adenocarcinoma
#17
Arthur Lui, Karen Mulder, Christine Brezden-Masley, Michael Vickers, Jose Monzon, Hagen Kennecke, Rakesh Goel, Larissa Vos, Sunita Ghosh, Horia Marginean, Anthony Fields, Jean Maroun, Jennifer Spratlin
Purpose Chemotherapy remains the primary treatment for metastatic gastric/GEJ cancer but optimal agents and schedule remain controversial. This study examined the safety and efficacy of first-line Irinotecan, capecitabine (Xeloda®), and Oxaliplatin (IXO). Patients and Methods Eligible patients with HER2-unamplified/unknown, metastatic gastric/GEJ adenocarcinoma were treated with 21-day cycle IXO at dose level 1 (DL1: Day 1 O-100 mg/m2 & I-160 mg/m2 IV, Day 2-15 X-1900 mg/m2 /day PO divided doses) or modified IXO (mIXO): Day 1 O-85 mg/m2 & I-120 mg/m2 IV, Day 2-15 X-1425 mg/m2 /day PO divided doses)...
May 4, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29724551/influence-of-low-temperature-degradation-on-the-wear-characteristics-of-zirconia-against-polymer-infiltrated-ceramic-network-material
#18
Zhichao Hao, Yuanyuan Ma, Wenjia Liu, Yukun Meng, Keisuke Nakamura, Jiefei Shen, Hang Wang
STATEMENT OF PROBLEM: Low-temperature degradation may affect zirconia restorations during their clinical service. Concerns have been raised about the effect of low-temperature degradation on the wear behavior of zirconia. Moreover, the wear resistance of this novel polymer-infiltrated ceramic-network material needs to be better evaluated. PURPOSE: The purpose of this in vitro study was to investigate the influence of aging on the wear resistance of zirconia opposing polymer-infiltrated ceramic-network material...
April 30, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29718329/antimicrobial-susceptibility-and-ribotypes-of-clostridium-difficile-isolates-from-a-phase-2-clinical-trial-of-ridinilazole-smt19969-and-vancomycin
#19
David R Snydman, Laura A McDermott, Cheleste M Thorpe, Justin Chang, Jenna Wick, Seth T Walk, Richard J Vickers
Objectives: We evaluated the antimicrobial susceptibility and ribotypes of Clostridium difficile isolates from participants in a Phase 2 study of ridinilazole, a novel targeted-spectrum agent for treatment of C. difficile infection. Methods: Participants received ridinilazole (200 mg twice daily) or vancomycin (125 mg four times daily) for 10 days (ClinicalTrials.gov: NCT02092935). The MICs of ridinilazole and comparators for C. difficile isolates from stool samples were determined by agar dilution...
April 30, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29713431/effects-of-incorporation-of-2-5-and-5-wt-tio-2-nanotubes-on-fracture-toughness-flexural-strength-and-microhardness-of-denture-base-poly-methyl-methacrylate-pmma
#20
Sahar Abdulrazzaq Naji, Marjan Behroozibakhsh, Tahereh Sadat Jafarzadeh Kashi, Hossein Eslami, Reza Masaeli, Hosseinali Mahgoli, Mohammadreza Tahriri, Mehrsima Ghavvami Lahiji, Vahid Rakhshan
PURPOSE: The aim of this preliminary study was to investigate, for the first time, the effects of addition of titania nanotubes (n-TiO2 ) to poly methyl methacrylate (PMMA) on mechanical properties of PMMA denture base. MATERIALS AND METHODS: TiO2 nanotubes were prepared using alkaline hydrothermal process. Obtained nanotubes were assessed using FESEM-EDX, XRD, and FT-IR. For 3 experiments of this study (fracture toughness, three-point bending flexural strength, and Vickers microhardness), 135 specimens were prepared according to ISO 20795-1:2013 (n of each experiment=45)...
April 2018: Journal of Advanced Prosthodontics
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