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https://www.readbyqxmd.com/read/28650255/patient-navigation-for-traumatic-brain-injury-promotes-community-re-integration-and-reduces-re-hospitalizations
#1
Emily R Rosario, Laura Espinoza, Stephanie Kaplan, Sepehr Khonsari, Earl Thurndyke, Melissa Bustos, Kayla Vickers, Brittney Navarro, Bonnie Scudder
OBJECTIVE: To determine the effectiveness of a Navigation programme for patients with traumatic brain injury. DESIGN: Prospective programme evaluation. SETTING: Inpatient rehabilitation facility and community settings. PARTICIPANTS: Eighteen individuals who suffered a traumatic brain injury (TBI), were between the ages of 16-70 years, and had a Rancho Score greater than IV. INTERVENTION: Patient navigation programme focused on identifying and addressing barriers to positive outcomes, including coordination of care and facilitating communication among the family and healthcare providers, psychosocial support, caregiver support, adherence to treatment, education, community resources and financial issues...
June 26, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28648462/cyclic-tetrapeptide-hdac-inhibitors-as-potential-therapeutics-for-spinal-muscular-atrophy-screening-with-ipsc-derived-neuronal-cells
#2
Jiun-I Lai, Luke J Leman, Sherman Ku, Chris J Vickers, Christian A Olsen, Ana Montero, M Reza Ghadiri, Joel M Gottesfeld
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder that is caused by inactivating mutations in the Survival of motor neuron 1 (SMN1) gene, resulting in decreased SMN protein expression. Humans possess a paralog gene, SMN2, which contains a splicing defect in exon 7 leading to diminished expression of full-length, fully functional SMN protein. Increasing SMN2 expression has been a focus of therapeutic development for SMA. Multiple studies have reported the efficacy of histone deacetylase inhibitors (HDACi) in this regard...
June 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28642458/the-structure-and-hardness-of-the-highest-boride-of-tungsten-a-borophene-based-compound
#3
Nevill Gonzalez Szwacki
Two-dimensional systems have strengthened their position as a key materials for novel applications. Very recently, boron joined the distinguished group of elements confirmed to possess 2D allotropes, named borophenes. In this work, we explore the stability and hardness of the highest borides of tungsten, which are built of borophenes separated by metal atoms. We show that the WB3+x compounds have Vickers hardnesses approaching 40 GPa only for small values of x. The insertion of extra boron atoms is, in general, detrimental to the hardness of WB3 because it leads to the formation of quasi-planar boron sheets that are less tightly connected with the adjacent tungsten layers...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28639437/ultrasound-assisted-green-economic-synthesis-of-hydroxyapatite-nanoparticles-using-eggshell-bio-waste-and-study-of-mechanical-and-biological-properties-for-orthopaedic-applications
#4
Vijay H Ingole, Kamal Hany Hussein, Anil A Kashale, Kalyani Ghule, Tomaž Vuherer, Vanja Kokol, Jia-Yaw Chang, Yong-Chien Ling, Aruna Vinchurkar, Hom N Dhakal, Anil V Ghule
Nanostructured hydroxyapatite (HAp) is most favorable candidate biomaterial for bone tissue engineering because of its bioactive and osteoconductive properties. Herein, we report for the first time ultrasound assisted facile and economic approach for the synthesis of nanocrystalline hydroxyapatite (Ca10 (PO4 )6 (OH)2 ) using recycled eggshell bio-waste referred as EHAp. The process involves the reaction of eggshell bio-waste as a source of calcium and ammonium dihydrogen orthophosphate as a phosphate source...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28638560/effects-of-different-percentages-of-microhydroxyapatite-on-microhardness-of-resin-modified-glass-ionomer-and-zirconomer
#5
Farahnaz Sharafeddin, Soodabe Shoale, Mahsa Kowkabi
BACKGROUND: Hydroxyapatite (HA) is the main mineral component of the tooth structure, which exhibits considerable biological behavior and its incorporation might improve microhardness of dental materials. Microhardness of restorative materials, like glass-ionomer, is critical for the clinical longevity of restorations. The aim of this study was to evaluate the microhardness of two glass-ionomers types by incorporating different percentages of microhydroxyapatite. MATERIAL AND METHODS: In this study, 80 disc-shaped experimental specimens (6 mm in diameter, 2 mm in height) were prepared in 8 groups, including resin-modified glass-ionomer (RMGI, GC, Gold Label, Japan), zirconia-reinforced glass-ionomer (Zirconomer, Shofu, Kyoto, Japan), and their mixture with 0, 5, 15 and 25 wt% of microhydroxyapatite (Sigma-Aldrich, Germany)...
June 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28625055/low-thermal-conductivity-and-high-thermoelectric-performance-in-gete-1-2x-gese-x-ges-x-competition-between-solid-solution-and-phase-separation
#6
Manisha Samanta, Kanishka Biswas
GeTe and its derivatives constituting Pb-free elements are well known as potential thermoelectric materials for the last five decades which offer paramount technological importance. The main constrain in the way of optimizing thermoelectric performance of GeTe is the high lattice thermal conductivity (κlat). Herein, we demonstrate low κlat (~0.7 W/mK) and significantly high thermoelectric figure of merit (ZT = 2.1 at 630 K) in Sb doped pseudoternary (GeTe)1-2x(GeSe)x(GeS)x system by two step strategies. (GeTe)1-2x(GeSe)x(GeS)x system provides an excellent podium to investigate competition between entropy driven solid solution and enthalpy driven phase separation...
June 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28624035/racial-disparities-in-length-of-stay-persist-even-with-no-postoperative-complications
#7
Matthew D Giglia, Aerin DeRussy, Melanie S Morris, Joshua S Richman, Mary T Hawn, Selwyn M Vickers, Sara J Knight, Daniel I Chu
BACKGROUND: To determine the contribution of race to postoperative length-of-stay in elective colorectal surgery without complications. METHODS: The 2012-2013 National Surgical Quality Improvement Program Colectomy-Targeted Database was queried for patients undergoing elective colorectal surgery without complications. After stratifying by race, univariate/bivariate comparisons were made. On adjusted comparison, predictors of postoperative length-of-stay were identified along with incident rate ratios and Least Squares Means for predicted length-of-stays...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28623722/recent-advances-in-synthetic-biology-for-engineering-isoprenoid-production-in-yeast
#8
REVIEW
Claudia E Vickers, Thomas C Williams, Bingyin Peng, Joel Cherry
Isoprenoids (terpenes/terpenoids) have many useful industrial applications, but are often not produced at industrially viable level in their natural sources. Synthetic biology approaches have been used extensively to reconstruct metabolic pathways in tractable microbial hosts such as yeast and re-engineer pathways and networks to increase yields. Here we review recent advances in this field, focusing on central carbon metabolism engineering to increase precursor supply, re-directing carbon flux for production of C10, C15, or C20 isoprenoids, and chemical decoration of high value diterpenoids (C20)...
June 14, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28611230/effect-of-a-motivational-interviewing-based-health-coaching-on-quality-of-life-in-subjects-with-copd
#9
Hamid Rehman, Craig Karpman, Kristin Vickers Douglas, Roberto P Benzo
BACKGROUND: Improving quality of life (QOL) is a key goal in the care of patients with COPD. Pulmonary rehabilitation (PR) has clearly been shown to improve QOL, but is not accessible to many eligible patients. There is a need for alternative programs designed to improve patient well-being that are accessible to all patients with COPD. Our goal was to pilot test a simple, telephone-based health-coaching intervention that was recently shown to decrease readmission among hospitalized COPD patients and stable COPD patients eligible for PR...
June 13, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28610838/bcl-2-expression-is-essential-for-development-and-normal-physiological-properties-of-tooth-hard-tissue-and-saliva-production
#10
Mohammad Ali Saghiri, Armen Asatourian, Zafer Gurel, Christine M Sorenson, Nader Sheibani
BACKGROUND: Apoptosis plays a fundamental role in appropriate tissue development and function. Although expression of Bcl-2 has been reported during tooth and submandibular gland (SMG) development, the physiological role Bcl-2 plays during these processes has not been addressed. This study was performed to evaluate the impact of Bcl-2 expression on the formation and properties of tooth hard tissue, and saliva production. METHODS: Twenty-four mice (12 males and 12 females) were divided into three groups of eight (n=8): group A (Bcl-2 +/+), group B (Bcl-2 +/-), and group C (Bcl-2 -/-) and subjected to micro-CT analyses...
June 10, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28609496/effect-of-ceramic-barriers-of-different-thicknesses-on-microhardness-of-light-cured-resin-cements
#11
Yasmin Alves do Nascimento, Ayla Macyelle de Oliveira Correia, Darlon Martins Lima, Sandro Griza, Wilton Mitsunari Takeshita, Adriano Augusto Melo de Mendonça
This study evaluated the microhardness of two resin cements and a low-viscosity resin composite when light-cured under different ceramic thicknesses. A total of 20 samples (10.0 × 1.0 mm) of each material were polymerized by means of a LED light source with an intensity of 1,100 mW/cm(2) for 20 seconds. For each experimental group, different ceramic thicknesses (0.5 mm, 1.0 mm, and 1.5 mm) were applied to each sample. For the control group, the samples were polymerized without the presence of ceramics. Each material was then stored in dry vials that inhibited the passage of light for a period of 24 hours...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28609494/effect-of-three-clinical-curing-treatments-on-fluoride-release-and-surface-hardness-of-glass-ionomer-cements
#12
Dimitrios Dionysopoulos, Kosmas Tolidis, Paris Gerasimou, Thrasyvoulos Sfeikos
The purpose of this study was to investigate the effect of radiant heat, ultrasonic treatment, and 42.7 wt% CaCl₂ solution on fluoride release and surface hardness in three conventional glass-ionomer cements (GICs). The fluoride release patterns of each GIC were evaluated during a 28-day period using a fluoride ion-selective electrode. The surface hardness of the tested GICs was evaluated 24 hours after preparation of the specimens using Vickers hardness test. Statistical analysis of the data was made using analysis of variance and Bonferroni post hoc test (α = ...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28609466/multi-level-multi-scale-resource-selection-functions-and-resistance-surfaces-for-conservation-planning-pumas-as-a-case-study
#13
Katherine A Zeller, T Winston Vickers, Holly B Ernest, Walter M Boyce
The importance of examining multiple hierarchical levels when modeling resource use for wildlife has been acknowledged for decades. Multi-level resource selection functions have recently been promoted as a method to synthesize resource use across nested organizational levels into a single predictive surface. Analyzing multiple scales of selection within each hierarchical level further strengthens multi-level resource selection functions. We extend this multi-level, multi-scale framework to modeling resistance for wildlife by combining multi-scale resistance surfaces from two data types, genetic and movement...
2017: PloS One
https://www.readbyqxmd.com/read/28607981/novel-structural-phases-and-the-electrical-properties-of-si3b-under-high-pressure
#14
Jingjing Wang, Guoliang Sun, Panlong Kong, Weiguo Sun, Cheng Lu, Feng Peng, Xiaoyu Kuang
We report a detailed theoretical study of the electronic structure, phase stability, elastic and mechanical properties of Si3B in the pressure range of 0-160 GPa by employing the crystal structure analysis by particle swarm optimization (CALYPSO) method combined with first-principles calculations. Our theoretical predictions reveal that, as the pressure increases, Si3B moves through the following sequence of phases: P3121 → C2/m → P21/m, and the corresponding transition pressures are computed to be 30 and 64 GPa, respectively...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28606045/patient-impressions-of-possible-catastrophic-outcomes-after-diabetic-foot-ulceration
#15
Benjamin Vickers, Javier La Fontaine, Naohiro Shibuya, Daniel C Jupiter, Zachary Ashmore
BACKGROUND: Diabetes mellitus (DM) and its complications are well studied; patients with diabetes may suffer from neuropathy and vascular issues, and associated with these, lower extremity ulceration. Ulcers are often refractory to treatment, and can be difficult for both patients and clinicians to manage. Such complications may lead to amputations, which in turn are a risk factor for death. However, in certain situations amputation may be the only option available, and may be used as reconstructive surgery, restoring function...
June 12, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28594746/enhanced-recovery-after-surgery-eras-eliminates-racial-disparities-in-postoperative-length-of-stay-after-colorectal-surgery
#16
Tyler S Wahl, Lauren E Goss, Melanie S Morris, Allison A Gullick, Joshua S Richman, Gregory D Kennedy, Jamie A Cannon, Selwyn M Vickers, Sara J Knight, Jeffrey W Simmons, Daniel I Chu
OBJECTIVE: To investigate the effects of enhanced recovery after surgery (ERAS) on racial disparities in postoperative length of stay (pLOS) after colorectal surgery. BACKGROUND: Racial disparities in surgical outcomes exist. We hypothesized that ERAS would reduce disparities in pLOS between black and white patients. METHODS: Patients undergoing ERAS in 2015 were 1:1 matched by race/ethnicity, age, sex, and procedure to a pre-ERAS group from 2010 to 2014...
June 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28591638/interrupted-glucagon-signaling-reveals-hepatic-%C3%AE-cell-axis-and-role-for-l-glutamine-in-%C3%AE-cell-proliferation
#17
E Danielle Dean, Mingyu Li, Nripesh Prasad, Scott N Wisniewski, Alison Von Deylen, Jason Spaeth, Lisette Maddison, Anthony Botros, Leslie R Sedgeman, Nadejda Bozadjieva, Olga Ilkayeva, Anastasia Coldren, Greg Poffenberger, Alena Shostak, Michael C Semich, Kristie I Aamodt, Neil Phillips, Hai Yan, Ernesto Bernal-Mizrachi, Jackie D Corbin, Kasey C Vickers, Shawn E Levy, Chunhua Dai, Christopher Newgard, Wei Gu, Roland Stein, Wenbiao Chen, Alvin C Powers
Decreasing glucagon action lowers the blood glucose and may be useful therapeutically for diabetes. However, interrupted glucagon signaling leads to α cell proliferation. To identify postulated hepatic-derived circulating factor(s) responsible for α cell proliferation, we used transcriptomics/proteomics/metabolomics in three models of interrupted glucagon signaling and found that proliferation of mouse, zebrafish, and human α cells was mTOR and FoxP transcription factor dependent. Changes in hepatic amino acid (AA) catabolism gene expression predicted the observed increase in circulating AAs...
June 6, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28590894/hearing-characteristics-of-stroke-patients-prevalence-and-characteristics-of-hearing-impairment-and-auditory-processing-disorders-in-stroke-patients
#18
Nehzat Koohi, Deborah A Vickers, Rahul Lakshmanan, Hoskote Chandrashekar, David J Werring, Jason D Warren, Doris-Eva Bamiou
BACKGROUND: Stroke survivors may suffer from a range of hearing impairments that may restrict their participation in postacute rehabilitation programs. Hearing impairment may have a significant impact on listening, linguistic skills, and overall communication of the affected stroke patient. However, no studies sought to systematically characterize auditory function of stroke patients in detail, to establish the different types of hearing impairments in this cohort of patients. Such information would be clinically useful in understanding and addressing the hearing needs of stroke survivors...
June 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28585929/association-between-the-serotonin-transporter-gene-polymorphism-and-verbal-learning-in-older-adults-is-moderated-by-gender
#19
A-R Imlach, D D Ward, J C Vickers, M J Summers, K L Felmingham
The S allele of the functional 5-HTTLPR polymorphism has previously been associated with reductions in memory function. Given the change in function of the serotonergic system in older adults, and the functional consequences of memory decline in this age group, further investigation into the impact of 5-HTTLPR in healthy older adults is required. This investigation examined the effect of 5-HTTLPR variants (S carriers versus L/L homozygotes) on verbal and visual episodic memory in 438 healthy older adults participating in the Tasmanian Healthy Brain Project (age range 50-79 years, M=60...
June 6, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28584748/papilliferous-keratoameloblastoma-a-rare-case-report
#20
Ajit Singh Rathore, Saurabh Juneja, Neha Khurana, Devi Charan Shetty
Ameloblastoma is true odontogenic tumor of epithelial origin, which is described as locally aggressive with varying chances of recurrence. It is believed to derive from enamel organ, remnants of dental lamina, lining of odontogenic cysts, or basal cells of oral epithelium. Radiologically, it may present as unilocular or multilocular radiolucency commonly. Although conventional ameloblastoma presents typical histological features as described by Vickers and Gorlin, few unusual variants have been reported with different histological patterns...
April 2017: International Journal of Applied and Basic Medical Research
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