Alessandro Rodolico, Pierfelice Cutrufelli, Antonio Di Francesco, Andrea Aguglia, Gaetano Catania, Carmen Concerto, Alessandro Cuomo, Andrea Fagiolini, Giuseppe Lanza, Ludovico Mineo, Antimo Natale, Laura Rapisarda, Antonino Petralia, Maria Salvina Signorelli, Eugenio Aguglia
BACKGROUND: Unipolar and bipolar depression present treatment challenges, with patients sometimes showing limited or no response to standard medications. Ketamine and its enantiomer, esketamine, offer promising alternative treatments that can quickly relieve suicidal thoughts. This Overview of Reviews (OoR) analyzed and synthesized systematic reviews (SRs) with meta-analysis on randomized clinical trials (RCTs) involving ketamine in various formulations (intravenous, intramuscular, intranasal, subcutaneous) for patients with unipolar or bipolar depression...
2024: Frontiers in Psychiatry