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REVIEW
Jillian Ashley-Martin, Jacob Hammond, Maria P Velez
In 2022, approximately one out of six people globally experienced infertility at some point in their life. Environmental chemicals, particularly those with endocrine disrupting activity, may contribute to impaired fecundity and infertility. We review existing prospective cohort studies of environmental chemicals and fecundity, identify methodological challenges and biases, and outline future research priorities. Studies of preconception environmental chemical exposures and fecundity have occurred in US, Singapore, China and Denmark with recruitment as early as 1982-1986, as recent as 2015-2017 and sample sizes ranging from 99 to 936...
March 22, 2024: Reproductive Toxicology
#22
JOURNAL ARTICLE
Tohidul Islam, Hlin Kvartsberg, Anuradha Sehrawat, Przemysław R Kac, Bruno Becker, Maria Olsson, Eric E Abrahamson, Henrik Zetterberg, Milos D Ikonomovic, Kaj Blennow, Thomas K Karikari
INTRODUCTION: Tau aggregation into paired helical filaments and neurofibrillary tangles is characteristic of Alzheimer's disease (AD) and related disorders. However, biochemical assays for the quantification of soluble, earlier-stage tau aggregates are lacking. We describe an immunoassay that is selective for tau oligomers and related soluble aggregates over monomers. METHODS: A homogeneous (single-antibody) immunoassay was developed using a novel anti-tau monoclonal antibody and validated with recombinant and brain tissue-derived tau...
March 23, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#23
REVIEW
Wendy S Rubinstein, Christos Patriotis, Anthony Dickherber, Paul K J Han, Hormuzd A Katki, Elyse LeeVan, Paul F Pinsky, Philip C Prorok, Amanda L Skarlupka, Sarah M Temkin, Philip E Castle, Lori M Minasian
Multicancer detection (MCD) tests use a single, easily obtainable biospecimen, such as blood, to screen for more than one cancer concurrently. MCD tests can potentially be used to improve early cancer detection, including cancers that currently lack effective screening methods. However, these tests have unknown and unquantified benefits and harms. MCD tests differ from conventional cancer screening tests in that the organ responsible for a positive test is unknown, and a broad diagnostic workup may be necessary to confirm the location and type of underlying cancer...
March 22, 2024: CA: a Cancer Journal for Clinicians
#24
REVIEW
Jamie E Jeon, Yasal Rajapaksa, Shaf Keshavjee, Mingyao Liu
Ischemia-reperfusion (IR) injury contributes to primary graft dysfunction, a major cause of early mortality after lung transplantation. Transcriptomics uses high-throughput techniques to profile the RNA transcripts within a sample and provides a unique view of the mechanisms underlying various biological processes. This review aims to highlight the applications of transcriptomics in lung IR injury studies, which have thus far revealed inflammatory responses to be the major event activated by IR, identified potential biomarkers and therapeutic targets, and investigated the mechanisms of therapeutic interventions...
March 19, 2024: Journal of Heart and Lung Transplantation
#25
REVIEW
Juliana N Vitti, Robert Vitti, Karen Chu, Scott Mellis
There is an urgent need for increased understanding of COVID-19 and strategies for its prevention, treatment, and mitigation. All participants in the research enterprise, including institutional review boards, have an ethical duty to protect participants and ensure that the benefits gained from such research do not conflict with the core principles that guided researchers prior to the pandemic. In this review, we discuss the ethical issues surrounding initiation and conduct of clinical trials, focusing on novel COVID-19 therapeutic, vaccine, or biospecimen research, using the principles of autonomy, beneficence, and justice...
2024: Frontiers in Public Health
#26
JOURNAL ARTICLE
Zdenka Pausova, Eeva Sliz
Metabolomics technologies enable the quantification of multiple metabolomic measures simultaneously, which provides novel insights into molecular aspects of human health and disease. In large-scale, population-based studies, blood is often the preferred biospecimen. Circulating metabolome may relate to brain health either by affecting or reflecting brain metabolism. Peripheral metabolites may act at or cross the blood-brain barrier and, subsequently, influence brain metabolism, or they may reflect brain metabolism if similar pathways are engaged...
March 21, 2024: Current Topics in Behavioral Neurosciences
#27
JOURNAL ARTICLE
Tinya Lin, Catherine Allaire, Sawsan As-Sanie, Pamela Stratton, Katy Vincent, G David Adamson, Lars Arendt-Nielsen, Deborah Bush, Femke Jansen, Jennifer Longpre, Luk Rombauts, Jay Shah, Abeesha Toussaint, Lone Hummelshoj, Stacy A Missmer, Paul J Yong
OBJECTIVE: The World Endometriosis Research Foundation (WERF) established the Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) to create standardized documentation tools (with common data elements) to facilitate the comparison and combination of data across different research sites and studies. In 2014, four data research standards were published: clinician-reported surgical data, patient-reported clinical data, and fluid and tissue biospecimen collection. Our current objective is to create an EPHect standard for the clinician-reported physical examination (EPHect-PE) for research studies...
March 18, 2024: Fertility and Sterility
#28
JOURNAL ARTICLE
Baohai Shao, Masami Shimizu-Albergine, Farah Kramer, Jenny E Kanter, Jay W Heinecke, Tomas Vaisar, Bettina Mittendorfer, Bruce W Patterson, Karin E Bornfeldt
Altered apolipoprotein kinetics play a critical role in promoting dyslipidemia and atherogenesis. Human apolipoprotein kinetics have been extensively evaluated, but similar studies in mice are hampered by the lack of robust methods suitable for the small amounts of blood that can be collected at sequential time points from individual mice. We describe a targeted liquid chromatography tandem mass spectrometry method for simultaneously quantifying the stable isotope enrichment of several apolipoproteins represented by multiple peptides in serial blood samples (15 μL each) obtained after retro-orbital injection of 13 C6 ,15 N2 -lysine (Lys8) in mice...
March 13, 2024: Journal of Lipid Research
#29
JOURNAL ARTICLE
Sunita Regmi, Paraskevi A Farazi, Elizabeth Lyden, Anupam Kotwal, Apar Kishor Ganti, Whitney Goldner
CONTEXT: Rural-urban disparities have been reported in cancer care, but data are sparse on the effect of geography and location of residence on access to care in thyroid cancer. OBJECTIVE: To identify impact of rural or urban residence and distance from treatment center on thyroid cancer stage at diagnosis. METHODS: We evaluated 800 adults with differentiated thyroid cancer in the iCaRe2 bioinformatics/biospecimen registry at the Fred and Pamela Buffett Cancer Center...
March 12, 2024: Journal of the Endocrine Society
#30
JOURNAL ARTICLE
Katrin Schaper-Gerhardt, Ralf Gutzmer, Yenny Angela, Lisa Zimmer, Elisabeth Livingstone, Dirk Schadendorf, Jessica C Hassel, Carsten Weishaupt, Bernhard Remes, Linda Kubat, Ivelina Spassova, Jürgen C Becker
BACKGROUND: Recent evidence suggests additional immunomodulatory properties of RANKL inhibition possibly boosting the clinical efficacy of immune checkpoint inhibitors (ICI). METHODS: We conducted a prospective, multicentre clinical trial in unresectable stage IV melanoma patients with bone metastases who received denosumab in parallel with dual ICI (BONEMET) and performed comprehensive immune monitoring at baseline and 4, 12, and 24 weeks after initiation of therapy...
March 2, 2024: European Journal of Cancer
#31
JOURNAL ARTICLE
James R Winkler, Barbara L Dixon, Ishita Singh, Ray Soto, Yuqing Qiu, Yue Zhang, Christina A Porucznik, Joseph B Stanford
Environmental toxins are known to have many impacts on growth and development in humans, starting in utero. Alterations in amelogenesis, caused by chemical and physical trauma that occur during the antenatal, perinatal and postnatal time periods, may result in developmental defects in deciduous and permanent tooth enamel, as demonstrated in animal studies. These defects can be clinically visible and result in a variety of morphological and functional problems in the dentition. Since enamel does not remodel after formation, it may serve as a permanent record of insults during organ development...
March 11, 2024: BMC Oral Health
#32
JOURNAL ARTICLE
Charles A Brunette, Thomas Yi, Morgan E Danowski, Mark Cardellino, Alicia Harrison, Themistocles L Assimes, Joshua W Knowles, Kurt D Christensen, Amy C Sturm, Yan V Sun, Qin Hui, Saiju Pyarajan, Yunling Shi, Stacey B Whitbourne, J Michael Gaziano, Sumitra Muralidhar, Jason L Vassy
OBJECTIVE: The development of clinical research informatics tools and workflow processes associated with re-engaging biobank participants has become necessary as genomic repositories increasingly consider the return of actionable research results. MATERIALS AND METHODS: Here we describe the development and utility of an informatics application for participant recruitment and enrollment management for the Veterans Affairs Million Veteran Program Return Of Actionable Results Study, a randomized controlled pilot trial returning individual genetic results associated with familial hypercholesterolemia...
April 2024: JAMIA Open
#33
JOURNAL ARTICLE
Andres Ramos-Fresnedo, Rawan Al-Kharboosh, Erin L Twohy, Aleeshba N Basil, Ewa C Szymkiewicz, Abba C Zubair, Daniel M Trifiletti, Nisha Durand, Dennis W Dickson, Erik H Middlebrooks, David N Abarbanel, Stephany Y Tzeng, Joao Paulo Almeida, Kaisorn L Chaichana, Jordan J Green, Wendy J Sherman, Alfredo Quiñones-Hinojosa
BACKGROUND AND OBJECTIVES: Despite standard of care with maximal safe resection and chemoradiation, glioblastoma is the most common and aggressive type of primary brain cancer. Surgical resection provides a window of opportunity to locally treat gliomas while the patient is recovering, and before initiating concomitant chemoradiation. To assess the safety and establish the maximum tolerated dose of adipose-derived mesenchymal stem cells (AMSCs) for the treatment of recurrent glioblastoma (GBM)...
December 2023: Neurosurg Pract
#34
Yvette C Paulino, Frank Camacho, Tristan Vc Paulino, Delores J Lee, Lisa Linda Natividad, Elizabeth Matisoo-Smith, Tony R Merriman, Anna Gosling
Background Gout, the most common inflammatory arthritis disease, and hyperuricaemia onset are influenced by environmental and genetic factors. We sought to investigate these factors in an Indigenous community in Guam. Methods In this cross-sectional study, the University of Guam led the qualitative inquiry with the native community, training (pre-screening of participants, data collection methods, and biospecimen handling), study implementation (outreach and recruitment, data collection, and DNA extraction and quantification), and qualitative and epidemiologic data analyses...
February 22, 2024: Research Square
#35
JOURNAL ARTICLE
Margit Bistrup Fischer, Gylli Mola, Lone Scheel, Katrine Bak Wraae, Ane Lilleøre Rom, Hanne Frederiksen, Trine Holm Johannsen, Kristian Almstrup, Karin Sundberg, Hanne Kristine Hegaard, Anders Juul, Casper P Hagen
BACKGROUND: Development of the gonads during fetal life is complex and vital for adult reproductive health. Cell and animal studies have shown an alarming effect of mild analgesics on germ cells in both males and females. More than 50% of pregnant women use mild analgesics during pregnancy, which potentially could compromise the reproductive health of the next generation. OBJECTIVES: We present a research protocol designed to evaluate the effect of prenatal exposure to mild analgesics and endocrine-disrupting chemicals on gonadal function in the offspring...
March 7, 2024: Paediatric and Perinatal Epidemiology
#36
JOURNAL ARTICLE
Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix, Matthew R Broome, Kate Buccilli, Kristin S Cadenhead, Monica E Calkins, Tyrone D Cannon, Guillermo Cecci, Eric Yu Hai Chen, Kang Ik K Cho, Jimmy Choi, Scott R Clark, Michael J Coleman, Philippe Conus, Cheryl M Corcoran, Barbara A Cornblatt, Covadonga M Diaz-Caneja, Dominic Dwyer, Bjørn H Ebdrup, Lauren M Ellman, Paolo Fusar-Poli, Liliana Galindo, Pablo A Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Robert Glynn, Michael P Harms, Leslie E Horton, René S Kahn, Joseph Kambeitz, Lana Kambeitz-Ilankovic, John M Kane, Tina Kapur, Matcheri S Keshavan, Sung-Wan Kim, Nikolaos Koutsouleris, Marek Kubicki, Jun Soo Kwon, Kerstin Langbein, Kathryn E Lewandowski, Gregory A Light, Daniel Mamah, Patricia J Marcy, Daniel H Mathalon, Patrick D McGorry, Vijay A Mittal, Merete Nordentoft, Angela Nunez, Ofer Pasternak, Godfrey D Pearlson, Jesus Perez, Diana O Perkins, Albert R Powers, David R Roalf, Fred W Sabb, Jason Schiffman, Jai L Shah, Stefan Smesny, Jessica Spark, William S Stone, Gregory P Strauss, Zailyn Tamayo, John Torous, Rachel Upthegrove, Mark Vangel, Swapna Verma, Jijun Wang, Inge Winter-van Rossum, Daniel H Wolf, Phillip Wolff, Stephen J Wood, Alison R Yung, Carla Agurto, Mario Alvarez-Jimenez, Paul Amminger, Marco Armando, Ameneh Asgari-Targhi, John Cahill, Ricardo E Carrión, Eduardo Castro, Suheyla Cetin-Karayumak, M Mallar Chakravarty, Youngsun T Cho, David Cotter, Simon D'Alfonso, Michaela Ennis, Shreyas Fadnavis, Clara Fonteneau, Caroline Gao, Tina Gupta, Raquel E Gur, Ruben C Gur, Holly K Hamilton, Gil D Hoftman, Grace R Jacobs, Johanna Jarcho, Jie Lisa Ji, Christian G Kohler, Paris Alexandros Lalousis, Suzie Lavoie, Martin Lepage, Einat Liebenthal, Josh Mervis, Vishnu Murty, Spero C Nicholas, Lipeng Ning, Nora Penzel, Russell Poldrack, Pablo Polosecki, Danielle N Pratt, Rachel Rabin, Habiballah Rahimi Eichi, Yogesh Rathi, Avraham Reichenberg, Jenna Reinen, Jack Rogers, Bernalyn Ruiz-Yu, Isabelle Scott, Johanna Seitz-Holland, Vinod H Srihari, Agrima Srivastava, Andrew Thompson, Bruce I Turetsky, Barbara C Walsh, Thomas Whitford, Johanna T W Wigman, Beier Yao, Hok Pan Yuen, Uzair Ahmed, Andrew Jin Soo Byun, Yoonho Chung, Kim Do, Larry Hendricks, Kevin Huynh, Clark Jeffries, Erlend Lane, Carsten Langholm, Eric Lin, Valentina Mantua, Gennarina Santorelli, Kosha Ruparel, Eirini Zoupou, Tatiana Adasme, Lauren Addamo, Laura Adery, Munaza Ali, Andrea Auther, Samantha Aversa, Seon-Hwa Baek, Kelly Bates, Alyssa Bathery, Johanna M M Bayer, Rebecca Beedham, Zarina Bilgrami, Sonia Birch, Ilaria Bonoldi, Owen Borders, Renato Borgatti, Lisa Brown, Alejandro Bruna, Holly Carrington, Rolando I Castillo-Passi, Justine Chen, Nicholas Cheng, Ann Ee Ching, Chloe Clifford, Beau-Luke Colton, Pamela Contreras, Sebastián Corral, Stefano Damiani, Monica Done, Andrés Estradé, Brandon Asika Etuka, Melanie Formica, Rachel Furlan, Mia Geljic, Carmela Germano, Ruth Getachew, Mathias Goncalves, Anastasia Haidar, Jessica Hartmann, Anna Jo, Omar John, Sarah Kerins, Melissa Kerr, Irena Kesselring, Honey Kim, Nicholas Kim, Kyle Kinney, Marija Krcmar, Elana Kotler, Melanie Lafanechere, Clarice Lee, Joshua Llerena, Christopher Markiewicz, Priya Matnejl, Alejandro Maturana, Aissata Mavambu, Rocío Mayol-Troncoso, Amelia McDonnell, Alessia McGowan, Danielle McLaughlin, Rebecca McIlhenny, Brittany McQueen, Yohannes Mebrahtu, Martina Mensi, Christy Lai Ming Hui, Yi Nam Suen, Stephanie Ming Yin Wong, Neal Morrell, Mariam Omar, Alice Partridge, Christina Phassouliotis, Anna Pichiecchio, Pierluigi Politi, Christian Porter, Umberto Provenzani, Nicholas Prunier, Jasmine Raj, Susan Ray, Victoria Rayner, Manuel Reyes, Kate Reynolds, Sage Rush, Cesar Salinas, Jashmina Shetty, Callum Snowball, Sophie Tod, Gabriel Turra-Fariña, Daniela Valle, Simone Veale, Sarah Whitson, Alana Wickham, Sarah Youn, Francisco Zamorano, Elissa Zavaglia, Jamie Zinberg, Scott W Woods, Martha E Shenton
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community...
March 7, 2024: Schizophrenia Bulletin
#37
JOURNAL ARTICLE
Richard McEnhill, Holly Borghese, Sarah A Moore
INTRODUCTION: Veterinary biobanks store samples for future use and distribute samples to academic researchers and industry entities; however, informed consent provided by owners for pets contributing to biobanks can be complicated by limited understanding of goals, purpose, and logistics of biobanking. METHODS: This survey-based study aimed to gather feedback from pet owners on how they viewed allowing their pet to contribute to a veterinary biobank, with the goal of identifying opportunities to improve education, awareness of veterinary biobanking initiatives, and the consent processes...
2024: Frontiers in Veterinary Science
#38
JOURNAL ARTICLE
Nameer Al-Yousif, Seyed M Nouraie, Matthew J Broerman, Yingze Zhang, Tomeka L Suber, John Evankovich, William G Bain, Georgios D Kitsios, Bryan J McVerry, Faraaz A Shah
BACKGROUND: Glucocorticoids are commonly used in patients with or at-risk for acute respiratory distress syndrome (ARDS), but optimal use remains unclear despite well-conducted clinical trials. We performed a secondary analysis in patients previously enrolled in the Acute Lung Injury and Biospecimen Repository at the University of Pittsburgh. The primary aim of our study was to investigate early changes in host response biomarkers in response to real-world use of glucocorticoids in patients with acute respiratory failure due to ARDS or at-risk due to a pulmonary insult...
March 5, 2024: Intensive Care Medicine Experimental
#39
REVIEW
Maria Iacobescu, Cristina Pop, Alina Uifălean, Cristina Mogoşan, Diana Cenariu, Mihnea Zdrenghea, Alina Tănase, Jon Thor Bergthorsson, Victor Greiff, Mihai Cenariu, Cristina Adela Iuga, Ciprian Tomuleasa, Dan Tătaru
Despite the numerous advantages of allogeneic hematopoietic stem cell transplants (allo-HSCT), there exists a notable association with risks, particularly during the preconditioning period and predominantly post-intervention, exemplified by the occurrence of graft-versus-host disease (GVHD). Risk stratification prior to symptom manifestation, along with precise diagnosis and prognosis, relies heavily on clinical features. A critical imperative is the development of tools capable of early identification and effective management of patients undergoing allo-HSCT...
2024: Frontiers in Immunology
#40
JOURNAL ARTICLE
Maryam Hashemian, Hossein Poustchi, Maryam Sharafkhah, Akram Pourshams, Fatemeh Mohammadi-Nasrabadi, Azita Hekmatdoost, Reza Malekzadeh
BACKGROUND: An association has already been hypothesized between iron, copper, and magnesium status assessed through food frequency questionnaires (FFQs) and the risk of esophageal squamous cell carcinoma (ESCC). However, self-reported dietary assessment methods are prone to measurement errors. We studied the association between iron, copper, and magnesium status and ESCC risk, using hair samples as a long exposure biomarker. METHODS: We designed a nested case-control study within the Golestan Cohort Study, that recruited about 50000 participants in 2004-2008, and collected biospecimens at baseline...
December 1, 2023: Archives of Iranian Medicine
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