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https://www.readbyqxmd.com/read/29220722/circulating-mirnas-expression-profiling-in-drug-resistant-epilepsy-up-regulation-of-mir-301a-3p-in-a-case-of-sudden-unexpected-death
#1
Maria De Matteis, Giovanni Cecchetto, Giada Munari, Laura Balsamo, Marina Paola Gardiman, Renzo Giordano, Guido Viel, Matteo Fassan
Sudden and unexpected death in epilepsy (SUDEP) represents one of the most challenging fields for clinical, forensic and preventative pathology. Several authors have emphasized the search of innovative biomarkers related to drug-resistance for an appropriate risk stratification in these patients. However, no reliable biomarker has been implemented into clinical practice, so far. Herein, we present a case of SUDEP due to drug-resistant mesial temporal lobe epilepsy (MTLE) in which we performed miRNA expression profiling (miR-301a-3p, miR-194-5p, miR-30b-5p, mIR-342-5p, and miR-4446-3p) from both the plasma and the temporal lobe in comparison to ten autopsies for traumatic or asphyxia deaths...
December 4, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29214569/rare-disease-biospecimens-and-patient-registries-interoperability-for-research-promotion-a-european-example-eurobiobank-and-spainrdr-bioner
#2
Yaffa R Rubinstein, Manuel Posada de la Paz, Marina Mora
Well-annotated and properly preserved specimens are crucial both for diagnostic purposes and for use in basic and pre-clinical research, and are especially important for rare disease (RD) studies. Several consortia have been established in the recent years in order to facilitate research and to maximise access to rare biological samples and data stored in rare disease biobanks and registries, among them the EuroBioBank network and the Spain National Rare Disease Registry (RDR) and Biobank (BioNER).EuroBioBank, established in 2001, was the first network of RD biobanks to operate in Europe as a service distributing human DNA, cells, and tissue to the scientific community conducting research on rare diseases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29207588/traceback-leveraging-archived-biospecimens-to-identify-mutation-carriers
#3
EDITORIAL
Goli Samimi, Mark E Sherman
No abstract text is available yet for this article.
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29190767/high-dna-stability-in-white-blood-cells-and-buffy-coat-lysates-stored-at-ambient-temperature-under-anoxic-and-anhydrous-atmosphere
#4
Anne-Lise Fabre, Aurélie Luis, Marthe Colotte, Sophie Tuffet, Jacques Bonnet
Conventional storage of blood-derived fractions relies on cold. However, lately, ambient temperature preservation has been evaluated by several independent institutions that see economic and logistic advantages in getting rid of the cold chain. Here we validated a novel procedure for ambient temperature preservation of DNA in white blood cell and buffy coat lysates based on the confinement of the desiccated biospecimens under anoxic and anhydrous atmosphere in original hermetic minicapsules. For this validation we stored encapsulated samples either at ambient temperature or at several elevated temperatures to accelerate aging...
2017: PloS One
https://www.readbyqxmd.com/read/29152064/development-of-a-population-based-cancer-case-control-study-in-southern-china
#5
Weimin Ye, Ellen T Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Liming Liang, Ingemar Ernberg, Thomas L Vaughan, Guangwu Huang, Yi Zeng, Yi-Xin Zeng, Hans-Olov Adami
With its population of over 1.3 billion persons, China offers abundant opportunities to discover causes of disease. However, few rigorous population-based case-control studies have as yet been conducted in mainland China. We conducted a population-based case-control study of nasopharyngeal carcinoma in Guangdong Province and Guangxi Autonomous Region. We collected questionnaires and biospecimens from incident cases recruited between March 2010 and December 2013, and population-based controls between November 2010 and November 2014...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29148940/a-functional-approach-to-assessing-consent-for-biospecimen-research
#6
Holly Fernandez Lynch
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148831/is-your-biobank-up-to-standards-a-review-of-the-national-canadian-tissue-repository-network-required-operational-practice-standards-and-the-controlled-documents-of-a-certified-biobank
#7
Victoria Hartman, Tania Castillo-Pelayo, Sindy Babinszky, Simon Dee, Jodi Leblanc, Lise Matzke, Sheila O'Donoghue, Jane Carpenter, Candace Carter, Amanda Rush, Jennifer Byrne, Rebecca Barnes, Anne-Marie Mes-Messons, Peter Watson
Ongoing quality management is an essential part of biobank operations and the creation of high quality biospecimen resources. Adhering to the standards of a national biobanking network is a way to reduce variability between individual biobank processes, resulting in cross biobank compatibility and more consistent support for health researchers. The Canadian Tissue Repository Network (CTRNet) implemented a set of required operational practices (ROPs) in 2011 and these serve as the standards and basis for the CTRNet biobank certification program...
November 17, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29147853/biospecimen-donation-among-black-and-white-breast-cancer-survivors-opportunities-to-promote-precision-medicine
#8
Vanessa B Sheppard, Alejandra Hurtado-de-Mendoza, Yun-Ling Zheng, Ying Wang, Kristi D Graves, Tania Lobo, Hanfei Xu, Yvonne Jennings, Dennis Tolsma, Martha Trout, Brandi E Robinson, Brittany McKinnon, Mahlet Tadesse
PURPOSE: Advances in precision medicine (PM) have potential to reduce and/or eliminate breast cancer disparities in both treatment and survivorship. However, compared to white Americans, black Americans are often underrepresented in genetic research. This report assessed factors that influence receipt of buccal cells via saliva kits. METHODS: This prospective study recruited women with confirmed hormonal-positive (HR+) breast cancer (BC). A standardized telephone survey collected sociodemographic, socio-cultural (e...
November 16, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29124112/concise-informed-consent-to-increase-data-and-biospecimen-access-may-accelerate-innovative-alzheimer-s-disease-treatments
#9
REVIEW
Ann M Hake, Penny A Dacks, Stephen P Arnerić
Introduction: Informed consent forms that restrict the distribution of data and samples have been an impediment to advancing Alzheimer's disease (AD) understandings and treatments. The Coalition Against Major Disease public-private partnership developed concise addenda to responsibly broaden data access of informed consent forms. Methods: Coalition Against Major Disease members identified key elements for ensuring data and biospecimen access, and patient privacy protection according to applicable US law...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29117024/behavioral-genetics-in-criminal-and-civil-courts
#10
Maya Sabatello, Paul S Appelbaum
Although emerging findings in psychiatric and behavioral genetics create hope for improved prevention, diagnosis, and treatment of disorders, the introduction of such data as evidence in criminal and civil proceedings raises a host of ethical, legal, and social issues. Should behavioral and psychiatric genetic data be admissible in judicial proceedings? If so, what are the various means for obtaining such evidence, and for what purposes should its admission be sought and permitted? How could-and should-such evidence affect judicial outcomes in criminal and civil proceedings? And what are the potential implications of using behavioral and psychiatric genetic evidence for individuals and communities, and for societal values of equality and justice? This article provides an overview of the historical and current developments in behavioral genetics...
November 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29105802/circulating-micrornas-and-treatment-response-in-the-phase-ii-swog-s0925-study-for-patients-with-new-metastatic-hormone-sensitive-prostate-cancer
#11
Heather H Cheng, Melissa Plets, Hongli Li, Celestia S Higano, Catherine M Tangen, Neeraj Agarwal, Nicholas J Vogelzang, Maha Hussain, Ian M Thompson, Muneesh Tewari, Evan Y Yu
BACKGROUND: Previous studies suggest circulating, blood-based microRNAs (miRNAs) may serve as minimally invasive prostate cancer biomarkers, however there is limited data from prospective clinical trials. Here, we explore the role of candidate plasma miRNAs as potential biomarkers in the SWOG 0925 randomized phase II study of androgen deprivation combined with cixutumumab versus androgen deprivation alone in patients with new metastatic hormone-sensitive prostate cancer. METHODS: Correlative biospecimens, including circulating tumor cells (CTCs) and plasma for miRNA analysis, were collected at baseline and after 12 weeks on treatment from 50 patients enrolled on SWOG 0925...
November 6, 2017: Prostate
https://www.readbyqxmd.com/read/29073807/an-assessment-of-a-shortened-consent-form-for-the-storage-and-research-use-of-residual-newborn-screening-blood-spots
#12
Erin Rothwell, Aaron Goldenberg, Erin Johnson, Naomi Riches, Beth Tarini, Jeffrey R Botkin
As state newborn screening programs develop approaches to parental permission for the storage and use of residual dried newborn screening samples, it is important to understand how the public comprehends the consent elements. Focus groups in Utah, California, and Michigan ( n = 7 groups, 69 participants) were conducted to evaluate the language on a shortened consent form. Outcomes from the analysis included barriers to conceptualizing biospecimen research, the overly cautious tone and awkwardness of the consent form, and perceptions of community versus individual benefit...
October 1, 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/29065913/urine-s100-proteins-as-potential-biomarkers-of-lupus-nephritis-activity
#13
Jessica L Turnier, Ndate Fall, Sherry Thornton, David Witte, Michael R Bennett, Simone Appenzeller, Marisa S Klein-Gitelman, Alexei A Grom, Hermine I Brunner
BACKGROUND: Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both serum and urine as potential biomarkers of global and renal system-specific disease activity in childhood-onset systemic lupus erythematosus (cSLE). METHODS: In this multicenter study, S100 proteins were measured in the serum and urine of four cSLE cohorts and healthy control subjects using commercial enzyme-linked immunosorbent assays...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065378/clinical-relevance-of-molecular-diagnostics-in-gastrointestinal-gi-cancer-european-society-of-digestive-oncology-esdo-expert-discussion-and-recommendations-from-the-17th-european-society-for-medical-oncology-esmo-world-congress-on-gastrointestinal-cancer-barcelona
#14
REVIEW
Alexander Baraniskin, Jean-Luc Van Laethem, Lucjan Wyrwicz, Ulrich Guller, Harpreet S Wasan, Tamara Matysiak-Budnik, Thomas Gruenberger, Michel Ducreux, Fatima Carneiro, Eric Van Cutsem, Thomas Seufferlein, Wolff Schmiegel
BACKGROUND AND SCOPE: In the epoch of precision medicine and personalised oncology, which aims to deliver the right treatment to the right patient, molecular genetic biomarkers are a topic of growing interest. The aim of this expert discussion and position paper is to review the current status of various molecular tests for gastrointestinal (GI) cancers and especially considering their significance for the clinical routine use. METHODOLOGY: Opinion leaders and experts from diverse nationalities selected on scientific merit were asked to answer to a prepared set of questions about the current status of molecular diagnostics in different GI cancers...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29064256/long-term-stability-of-human-plasma-metabolites-during-storage-at-80-%C3%A2-c
#15
Mark Haid, Caroline Muschet, Simone Wahl, Werner Römisch-Margl, Cornelia Prehn, Gabriele Möller, Jerzy Adamski
Prolonged storage of biospecimen can lead to artificially altered metabolite concentrations and thus bias data analysis in metabolomics experiments. To elucidate the potential impact of long-term storage on the metabolite profile, a pooled human plasma sample was aliquoted and stored at 80 °C. During a time period of five years, 1012 of the aliquots were measured with the Biocrates AbsoluteIDQ® p180 targeted-metabolomics assay at 193 time points. Modelling the concentration courses over time revealed that 55 out of 111 metabolites remained stable...
October 24, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29063513/variability-in-c-reactive-protein-is-associated-with-cognitive-impairment-in-women-living-with-and-without-hiv-a-longitudinal-study
#16
Leah H Rubin, Lorie Benning, Sheila M Keating, Philip J Norris, Jane Burke-Miller, Antonia Savarese, Krithika N Kumanan, Saria Awadalla, Gayle Springer, Kathyrn Anastos, Mary Young, Joel Milam, Victor G Valcour, Kathleen M Weber, Pauline M Maki
Despite the availability of effective antiretroviral therapies, cognitive impairment (CI) remains prevalent in HIV-infected (HIV+) individuals. Evidence from primarily cross-sectional studies, in predominantly male samples, implicates monocyte- and macrophage-driven inflammatory processes linked to HIV-associated CI. Thus, peripheral systemic inflammatory markers may be clinically useful biomarkers in tracking HIV-associated CI. Given sex differences in immune function, we focused here on whether mean and intra-individual variability in inflammatory marker-predicted CI in HIV+ and HIV- women...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29046347/investigating-immune-gene-signatures-in-peripheral-blood-from-subjects-with-allergic-rhinitis-undergoing-nasal-allergen-challenge
#17
Young Woong Kim, Amrit Singh, Casey P Shannon, Jenny Thiele, Lisa M Steacy, Anne K Ellis, Helen Neighbour, Daniel R Gliddon, Pascal L C Hickey, Mark Larché, Scott J Tebbutt
Nasal allergen challenge (NAC) is a human model of allergic rhinitis (AR) that delivers standardized allergens locally to the nasal mucosa allowing clinical symptoms and biospecimens such as peripheral blood to be collected. Although many studies have focused on local inflammatory sites, peripheral blood, an important mediator and a component of the systemic immune response, has not been well studied in the setting of AR. We sought to investigate immune gene signatures in peripheral blood collected after NAC under the setting of AR...
October 18, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29040820/systematic-review-of-the-effect-of-enteral-feeding-on-gut-microbiota-in-preterm-infants
#18
Wanli Xu, Michelle Judge, Kendra Maas, Naveed Hussain, Jacqueline M McGrath, Wendy A Henderson, Xiaomei Cong
OBJECTIVE: To examine the effect of feeding type on microbial patterns among preterm infants and to identify feeding factors that promote the colonization of beneficial bacteria. DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, Scopus, and the Cummulative Index of Nursing and Allied Health Literature were thoroughly searched for articles published between January 2000 and January 2017, using the keywords gut microbiome, gut microbiota, enteral microbiome, enteral microbiota, premature infant, preterm infant, extremely low birth weight infant, ELBW infant, very low birth weight infant, feeding, breast milk, breastfeeding, formula, prebiotic, probiotic, and long chain polyunsaturated fatty acid...
October 14, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29038786/micrornas-as-biomarkers-in-thyroid-carcinoma
#19
REVIEW
Marilena Celano, Francesca Rosignolo, Valentina Maggisano, Valeria Pecce, Michelangelo Iannone, Diego Russo, Stefania Bulotta
Optimal management of patients with thyroid cancer requires the use of sensitive and specific biomarkers. For early diagnosis and effective follow-up, the currently available cytological and serum biomarkers, thyroglobulin and calcitonin, present severe limitations. Research on microRNA expression in thyroid tumors is providing new insights for the development of novel biomarkers that can be used to diagnose thyroid cancer and optimize its management. In this review, we will examine some of the methods commonly used to detect and quantify microRNA in biospecimens from patients with thyroid tumor, as well as the potential applications of these techniques for developing microRNA-based biomarkers for the diagnosis and prognostic evaluation of thyroid cancers...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/29030865/the-22rv1-prostate-cancer-cell-line-carries-mixed-genetic-ancestry-implications-for-prostate-cancer-health-disparities-research-using-pre-clinical-models
#20
Leanne Woods-Burnham, Anamika Basu, Christina K Cajigas-Du Ross, Arthur Love, Clayton Yates, Marino De Leon, Sourav Roy, Carlos A Casiano
BACKGROUND: Understanding how biological factors contribute to prostate cancer (PCa) health disparities requires mechanistic functional analysis of specific genes or pathways in pre-clinical cellular and animal models of this malignancy. The 22Rv1 human prostatic carcinoma cell line was originally derived from the parental CWR22R cell line. Although 22Rv1 has been well characterized and used in numerous mechanistic studies, no racial identifier has ever been disclosed for this cell line...
December 2017: Prostate
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