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adjuvant treatment breast cancer

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https://www.readbyqxmd.com/read/29666928/implications-of-esr1-mutations-in-hormone-receptor-positive-breast-cancer
#1
REVIEW
Tomás Reinert, Rodrigo Gonçalves, José Bines
Endocrine treatment resistance eventually develops during adjuvant and even more often during hormonal treatment for advanced breast cancer (ABC). An ESR1 gene mutation, which encodes for the estrogen receptor (ER) protein, is one of the potential mechanisms of therapy resistance. The ESR1 mutations result in conformational changes in the ER leading to subsequent estrogen-independent transcriptional activity. These mutations are found at a lower level in early stage when compared to metastatic BC, more often through selective pressure after aromatase inhibitor (AI) treatment...
April 17, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29663927/encapsulation-of-5-flurouracil-into-plga-nanofibers-and-enhanced-anticancer-effect-in-combination-with-ajwa-dates-extract-phoenix-dactylifera-l
#2
Fazal Khan, Musab Aldhahri, Mohammad Asif Hussain, Kalamegam Gauthaman, Adnan Memic, Adel Abuzenadah, Taha Kumosani, Elie Barbour, Nazeeh Shuja Alothmany, Rabah Wasil Aldhaheri
Side effects connected with chemotherapeutic agents used in cancer treatment has led to alternative modalities of combinatorial therapies in an attempt to reduce the drug dosage and associated risks. In the current study we evaluated the potential use of Ajwa Dates Extract (ADE), reported to have anti-cancer effects, as an adjuvant therapy in combination with 5-flurouracil (5FU) against the human-breast-adenocarcinoma cell line (MFC-7) in vitro. The effects of ADE alone and in combination with 5-FU were evaluated in terms of cell viability and cytotoxicity...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29661777/interferon-stimulated-genes-are-involved-in-cross-resistance-to-radiotherapy-in-tamoxifen-resistant-breast-cancer
#3
Annemarie E M Post, Marcel Smid, Anika Nagelkerke, John W M Martens, Johan Bussink, Fred Cjg Sweep, Paul N Span
PURPOSE: Treatment resistance is a main cause of adverse disease outcome in breast cancer patients. Here we aimed to investigate common features in tamoxifen-resistant and radioresistant breast cancer, since tamoxifen-resistant breast cancer cells are cross-resistant to irradiation in vitro. EXPERIMENTAL DESIGN: RNA sequencing of tamoxifen-resistant and radioresistant breast cancer cells was performed and validated by quantitative PCR. Pathways were further investigated in vitro and in breast cancer patient cohorts to establish their relation with treatment resistance...
April 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29661243/effect-of-neoadjuvant-chemotherapy-regimen-on-relapse-free-survival-among-patients-with-breast-cancer-achieving-a-pathologic-complete-response-an-early-step-in-the-de-escalation-of-neoadjuvant-chemotherapy
#4
Anna Weiss, Sami I Bashour, Kenneth Hess, Alastair M Thompson, Nuhad K Ibrahim
BACKGROUND: Patients with breast cancer who have a pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) have improved survival. We hypothesize that once pCR has been achieved, there is no difference in subsequent postsurgical recurrence-free survival (RFS), whichever NACT regimen is used. METHODS: Data from patients with breast cancer who achieved pCR after NACT between 1996 and 2011 were reviewed. RFS was estimated by the Kaplan-Meier method, and differences between groups were assessed using log-rank testing...
April 16, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29660599/dosage-dependent-reduction-of-macular-pigment-optical-density-in-female-breast-cancer-patients-receiving-tamoxifen-adjuvant-therapy
#5
I-Liang Lim, Angela Voon Pei Loo, Visvaraja Subrayan, Tsung Fei Khang, Mee Hoong See, Adlinda Alip, Nur Aishah Mohd Taib
It is now increasingly common for breast cancer patients to receive adjuvant tamoxifen therapy for a period of up to 10 years. As survival rate increases, managing tamoxifen ocular toxicities is important for patients' quality of life. Macular pigments in photoreceptor cells protect against free radical damage, which can cause macular degeneration. By reducing macular pigment concentration, tamoxifen may increase the risk of macular degeneration. Here, we compared macular pigment optical density (MPOD) and central macular thickness between breast cancer patients on tamoxifen adjuvant therapy (n = 70), and a control group (n = 72)...
April 13, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29656223/delay-of-adjuvant-radiotherapy-due-to-postoperative-complications-after-oncoplastic-breast-conserving-surgery
#6
Nadine S Hillberg, Marleen A J Meesters-Caberg, Jop Beugels, Bjorn Winkens, Yvonne L J Vissers, Tom J M van Mulken
BACKGROUND: In the past a mastectomy was the first approach of treating breast cancer. Oncoplastic techniques combined with breast conserving surgery (BCS) and radiotherapy has become an alternative to mastectomy in patients with non-metastasized breast cancer. The aim of this study was to analyse the amount and types of complications occurring after oncoplastic BCS before and after adjuvant radiotherapy and the delay of adjuvant therapy due to the complications. METHOD: A retrospective study based on all patients who received immediate oncoplastic BCS by a plastic surgeon at two medical hospitals in The Netherlands between 2013 and 2015...
April 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29651596/predictors-of-attendance-to-an-oncologist-referred-exercise-program-for-women-with-breast-cancer
#7
Kelcey A Bland, Sarah E Neil-Sztramko, Amy A Kirkham, Alis Bonsignore, Cheri L Van Patten, Donald C McKenzie, Karen A Gelmon, Kristin L Campbell
PURPOSE: While exercise is associated with numerous benefits in women with breast cancer, adherence to exercise training concurrent to cancer treatment is challenging. We aimed to identify predictors of attendance to an oncologist-referred exercise program offered during and after adjuvant breast cancer treatment. METHODS: Women with early-stage breast cancer receiving chemotherapy (n = 68) enrolled in the Nutrition and Exercise During Adjuvant Treatment (NExT) study...
April 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29651367/-lazarus-response-to-olaparib-in-a-virtually-chemonaive-breast-cancer-patient-carrying-gross-brca2-gene-deletion
#8
Vladimir M Moiseyenko, Vyacheslav A Chubenko, Fedor V Moiseyenko, Lyudmila A Zagorskaya, Yuliya A Zaytseva, Nataliya E Gesha, Evgeny N Zykov, Valeriya I Ni, Elena V Preobrazhenskaya, Anna P Sokolenko, Evgeny N Imyanitov
This report describes an estrogen receptor-positive breast cancer patient, who relapsed at two and a half years after the completion of adjuvant chemotherapy while being on the aromatase inhibition. Based on the clinical evidence for potential sensitivity of the tumor to hormone ablation, everolimus was added to continuing exemestane treatment. Oral chemotherapy was administered at further disease progression, however, it lasted only for 10 days due to rapidly deteriorating condition of the patient. BRCA test was performed just before the failure of endocrine therapy and revealed a gross deletion within BRCA2 gene...
February 4, 2018: Curēus
https://www.readbyqxmd.com/read/29650905/-a-case-of-her2-positive-breast-cancer-with-liver-metastases-showing-three-years-of-complete-response-to-combination-therapy-with-trastuzumabplus-pertuzumab
#9
Yuri Fujimoto, Kazushige Yamaguchi, Ayako Ueno, Reo Sakurai, Yoshio Nagahisa, Shiro Imai, Kazuyuki Kawamoto
A 48-year-old woman with severe interstitial pneumonitis was diagnosed with right breast cancer(invasive ductal carcinoma, T1aN1M0, ER+, PgR-, HER2 3+)and underwent modified radical mastectomy.The patient was administered tamoxifen as adjuvant therapy.However, 1 year after the mastectomy, multiple liver metastases were found and the patient received 2 anti-HER2 agents, trastuzumab and pertuzumab.A complete response(CR)was observed with the disappearance of the liver metastases in 7 months.CR was maintained for 2 years after the initiation of treatment, and then, we started trastuzumab monotherapy, which has resulted in long-term disease control...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650388/evaluation-at-3-years-of-concurrent-bevacizumab-and-radiotherapy-for-breast-cancer-results-of-a-prospective-study
#10
A Dautruche, L Belin, P Cottu, P Bontemps, C Lemanski, B de la Lande, P Baumann, F Missohou, C Lévy, K Peignaux, A Reynaud-Bougnoux, F Denis, A Gobillion, V Pernin, Y Kirova
PURPOSE: To determine the 3 years late toxicity among patients with non-metastatic breast cancer who received concurrent bevacizumab and locoregional radiotherapy. MATERIAL AND METHODS: This is a single-arm, multicentre, prospective study, of the toxicity of adjuvant concomitant association of bevacizumab and radiotherapy in patients with breast cancer. Toxicity was assessed by the Common Terminology Criteria for Adverse Events version 3.0 during the radiotherapy and follow-up clinics at 12 and 36 months after its completion...
April 9, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29649080/investigating-changes-in-weight-and-body-composition-among-women-in-adjuvant-treatment-for-breast-cancer-a-scoping-review
#11
Birgith Pedersen, Charlotte Delmar, Tamás Lörincz, Ursula Falkmer, Mette Grønkjær
BACKGROUND: Despite several investigations, findings on weight changes during and after adjuvant treatment for breast cancer are diverse and point in several directions. OBJECTIVE: The aims of this study were to investigate changes in weight and body composition associated with contemporary anticancer medication and to examine factors that might influence the assessment and diversity of the findings. METHODS: This article used the method of a scoping review to map the body of literature...
April 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29644338/hypothesis-can-the-abscopal-effect-explain-the-impact-of-adjuvant-radiotherapy-on-breast-cancer-mortality
#12
REVIEW
Ismail Jatoi, John R Benson, Ian Kunkler
Radiotherapy is an integral component of loco-regional therapy for breast cancer. Randomized controlled trials indicate that increasing the extent of extirpative surgery primarily reduces the risk of local recurrences, while the addition of radiotherapy to surgery can also reduce the risk of distant recurrences, thereby lowering breast cancer-specific mortality. This may suggest an "abscopal" effect beyond the immediate zone of loco-regional irradiation that favorably perturbs the natural history of distant micrometastases...
2018: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29628986/chronological-improvement-in-survival-of-patients-with-breast-cancer-a-large-scale-single-center-study
#13
Sae Byul Lee, Guiyun Sohn, Jisun Kim, Il Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sung-Bae Kim, Sei-Hyun Ahn
Purpose: This study aimed to chronologically evaluate survival of patients with breast cancer in Korea and investigate the observed changes during the last 20 years. We also sought to determine factors that may influence outcomes and changes in the duration of survival over time. Methods: We retrospectively analyzed a total of 10,988 patients with breast cancer who were treated at our institution between January 1993 and December 2008. We divided the study period into three periods (P1, 1993-1997; P2, 1998-2002; and P3, 2003-2008)...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29627925/spirituality-in-african-american-breast-cancer-patients-implications-for-clinical-and-psychosocial-care
#14
Vanessa B Sheppard, Robin Walker, Winifred Phillips, Victoria Hudson, Hanfei Xu, Mark L Cabling, Jun He, Arnethea L Sutton, Jill Hamilton
Spirituality has been shown to be important to many individuals dealing with a cancer diagnosis. While African-American breast cancer survivors have been reported to have higher levels of spirituality compared to White women, little is known about how levels of spirituality may vary among African-American breast cancer survivors. The aims of this study were to examine factors associated with spirituality among African-American survivors and test whether spirituality levels were associated with women's attitudes about treatment or health care...
April 7, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29623820/chickpea-lectin-inhibits-human-breast-cancer-cell-proliferation-and-and-induces-apoptosis-through-cell-cycle-arrest
#15
Neha Gupta, Prakash S Bisen, Sameer Suresh Bhagyawant
BACKGROUND: Breast cancer demands safe adjuvant to overcome the side effects of standard drug tomoxifen. Diet derived bioactive compounds are reported to exhibit modulation of tumor growth leading to cell death. Chickpea is a protein rich edible legume with several bioactive compounds that includes lectin as well. Characterization of chickpea lectin and its effect against cancer cell has been investigated in this study. METHOD: Cicer arietinum L. lectin (CAL) agglutinating trypsin-treated rabbit blood cells was purified employing DEAE-cellulose and SP-sephadex ion exchange chromatography...
April 6, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29622383/invasive-breast-carcinoma-tumor-size-on-core-needle-biopsy-analysis-of-practice-patterns-and-effect-on-final-pathologic-tumor-stage
#16
Emmanuel Agosto-Arroyo, Maryam Tahmasbi, Sameer Al Diffalha, Laila Khazai, Yin Xiong, Marilin Rosa
INTRODUCTION: In the absence of nodal metastasis, pathologic tumor (pT) size remains one of the most important factors in adjuvant treatment decisions and patient prognosis in breast cancer. The aim of this study was to evaluate the effect of core needle biopsy (CNB) tumor size on final pT stage. MATERIALS AND METHODS: Our information system was searched to identify all patients who underwent excisional procedures for invasive breast carcinoma from January 1, 2014 to December 31, 2015...
March 5, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29621991/adjuvant-trastuzumab-duration-trials-in-her2-positive-breast-cancer-what-results-would-be-practice-changing-persephone-investigator-questionnaire-prior-to-primary-endpoint-results
#17
Louise Hiller, Janet A Dunn, Shrushma Loi, Anne-Laure Vallier, Donna L Howe, David A Cameron, David Miles, Andrew M Wardley, Helena M Earl
BACKGROUND: Twelve months treatment is the current standard of care for adjuvant trastuzumab in patients with HER2 positive early breast cancer however the optimal duration is not known. Persephone is a non-inferiority randomised controlled trial comparing 6- to 12-months of trastuzumab. In this trial there will be a trade-off between a possible small decrease in disease-free survival (DFS) with 6-months and reduced cardiotoxicity and cost. METHODS: A structured questionnaire asked clinicians who had recruited patients into the Persephone trial about their prior beliefs with regards to the clinical effectiveness of trastuzumab and cardiotoxicity profile, in the comparison of 6- and 12-month durations...
April 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29615063/prediction-of-treatment-responses-to-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer-by-analysis-of-immune-checkpoint-protein-expression
#18
Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: "Avoiding immune destruction" has recently been established as one of the hallmarks of cancer. The programmed cell death (PD)-1/programmed cell death-ligand (PD-L) 1 pathway is an important immunosuppression mechanism that allows cancer cells to escape host immunity. The present study investigated how the expressions of these immune checkpoint proteins affected responses to neo-adjuvant chemotherapy (NAC) in breast cancer. METHODS: A total of 177 patients with resectable early-stage breast cancer were treated with NAC...
April 4, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29614997/cancer-patients-knowledge-about-their-disease-and-treatment-before-during-and-after-treatment-a-prospective-longitudinal-study
#19
Ola Berger, Bjørn Henning Grønberg, Jon Håvard Loge, Stein Kaasa, Kari Sand
BACKGROUND: Knowledge about disease and treatment is necessary before patients can consent to treatment. One of the few established instruments for evaluating whether sufficient information has been provided, is the EORTC QLQ-INFO25 questionnaire which was developed to measure how patients perceive information. The aim of this study was to investigate whether cancer patients' level of knowledge about their disease and treatment was associated with their perception of and satisfaction with the information...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29611754/experience-with-eribulin-in-triple-negative-metastatic-breast-cancer-case-studies
#20
Maria Isabel Gallegos Sancho, Raúl Márquez-Vázquez, Alfonso Sánchez-Muñoz
Triple-negative breast cancers are defined as tumors negative for estrogen receptors, progesterone receptors and human EGFR2. These tumors exhibit diverse biological behavior and have a poor prognosis; chemotherapy is the mainstay of treatment. The first case involves a young woman with cerebral and cerebellar metastases who achieved a persistent objective response to fourth-line eribulin. In the second case, a woman who became metastatic during adjuvant therapy with anthracyclines and taxanes, and was refractory to capecitabine + bevacizumab, achieved a partial response and local symptom improvement with eribulin + bevacizumab...
March 2018: Future Oncology
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