Jian-hui Chang, Heng Zhang, Fang-xia Guan, Yue-ying Wang, De-guan Li, Hong-ying Wu, Cheng-chun Wang, Chang-hui Zhou, Zhi-bin Zhai, Lu Lu, Xiao-chun Wang, Qi Hou, Ai-min Meng
This study is to investigate the protective effects of the SB203580 against radiation induced mortality and intestinal injury of mice. A total of 67 male C57BL/6 mice (20.0-22.0 g) were matched according to body weight and randomly assigned to one of three groups: control, total body irradiation exposure (IR, 7.2 Gy) only, and IR (7.2 Gy) + SB203580 (15 mg x kg(-1)). 30 days survival rate was observed in the experiment. In intestinal injury experiment, the expression levels of caspase-3, Ki67, p53 and p-p38 were assayed in the mice intestine crypts...
April 2011: Yao Xue Xue Bao, Acta Pharmaceutica Sinica