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https://www.readbyqxmd.com/read/27005501/short-communication-rheological-properties-of-blood-serum-of-rats-after-irradiation-with-different-gamma-radiation-doses-in-vivo
#1
Mohamed Anwar K Abdelhalim, Sherif Aa Moussa, Al-Ayed Ms
The blood serum rheological properties open the door to find suitable radio-protectors and convenient therapy for many cases of radiation exposure. The present study aimed to investigate the rheological properties of rat blood serum at wide range of shear rates after whole body irradiation with different gamma radiation doses in vivo. Healthy male rats were divided into five groups; one control group and 4 irradiated groups. The irradiation process was carried out using Co60 source with dose rate of 0.883cG/sec...
January 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26944191/mnte-2-pyp-reduces-prostate-cancer-growth-and-metastasis-by-suppressing-p300-activity-and-p300-hif-1-creb-binding-to-the-promoter-region-of-the-pai-1-gene
#2
Qiang Tong, Michael R Weaver, Elizabeth A Kosmacek, Brian P O'Connor, Laura Harmacek, Sujatha Venkataraman, Rebecca E Oberley-Deegan
To improve radiation therapy-induced quality of life impairments for prostate cancer patients, the development of radio-protectors is needed. Our previous work has demonstrated that MnTE-2-PyP significantly protects urogenital tissues from radiation-induced damage. So, in order for MnTE-2-PyP to be used clinically as a radio-protector, it is fully necessary to explore the effect of MnTE-2-PyP on human prostate cancer progression. MnTE-2-PyP inhibited prostate cancer growth in the presence and absence of radiation and also inhibited prostate cancer migration and invasion...
May 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/25992214/radio-protective-role-of-antioxidant-agents
#3
REVIEW
Alireza Shirazi, Ehsan Mihandoost, Seied Rabie Mahdavi, Mehran Mohseni
Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related problems. Results of experimental research show that antioxidant nutrients, such as vitamin E and herbal products and melatonin, are protective against the damaging effects of radiation, with less toxicity and side effects...
October 2, 2012: Oncology Reviews
https://www.readbyqxmd.com/read/25685729/lycopene-as-a-carotenoid-provides-radioprotectant-and-antioxidant-effects-by-quenching-radiation-induced-free-radical-singlet-oxygen-an-overview
#4
REVIEW
Jalil Pirayesh Islamian, Habib Mehrali
Radio-protectors are agents that protect human cells and tissues from undesirable effects of ionizing radiation by mainly scavenging radiation-induced free radicals. Although chemical radio-protectors diminish these deleterious side effects they induce a number of unwanted effects on humans such as blood pressure modifications, vomiting, nausea, and both local and generalized cutaneous reactions. These disadvantages have led to emphasis on the use of some botanical radio-protectants as alternatives. This review has collected and organized studies on a plant-derived radio-protector, lycopene...
2015: Cell Journal
https://www.readbyqxmd.com/read/24772948/protective-effect-of-some-amino-acids-synthesized-derivatives-and-their-chelates-on-escherichia-coli-under-x-ray-irradiation
#5
G Kirakosyan, H Torgomyan, M Malakyan, S Bajinyan, A Trchounian
The protective effects of novel synthesized derivatives of some amino acids--nicotinyl-L-tyrosinate and nicotinyl-L-tryptophanate schiff bases and their Cu(II) and Mn(II) chelates on growth, survival and membrane-associated ATPase activity of E. coli under X-ray irradiation were investigated. The specific growth rate and survival of E. coli were decreased at 10, 20 and 30 Gy doses. However, as 30 Gy was found to be the most effective irradiation dose, it was chosen for studying the radio-protective properties of different compounds...
August 2013: Indian Journal of Biochemistry & Biophysics
https://www.readbyqxmd.com/read/24698988/ayurveda-for-chemo-radiotherapy-induced-side-effects-in-cancer-patients
#6
REVIEW
Kashinath Metri, Hemant Bhargav, Praerna Chowdhury, Prasad S Koka
Chemotherapy drugs and radiotherapy are highly toxic and both damage adjacent healthy cells. Side effects may be acute (occurring within few weeks after therapy), intermediate or late (occurring months or years after the therapy). Some important side effects of chemotherapy are: nausea, vomiting, diarrhea, mucositis, alopecia, constipation etc; whereas radiation therapy though administered locally, can produce systemic side effects such as fatigue, anorexia, nausea, vomiting, alteration in the taste, sleep disturbance, headache, anemia, dry skin, constipation etc...
2013: Journal of Stem Cells
https://www.readbyqxmd.com/read/24692054/isofraxidin-a-potent-reactive-oxygen-species-ros-scavenger-protects-human-leukemia-cells-from-radiation-induced-apoptosis-via-ros-mitochondria-pathway-in-p53-independent-manner
#7
Peng Li, Qing-Li Zhao, Li-Hua Wu, Paras Jawaid, Yu-Fei Jiao, Makoto Kadowaki, Takashi Kondo
Ionizing radiation (IR) leads to oxidizing events such as excessive reactive oxygen species (ROS) in the exposed cells, resulting in further oxidative damage to lipids, proteins and DNA. To screen the potential radio-protective drug, the intracellular ROS was measured in irradiated U937 cells pretreated with 80 candidate traditional herbal medicine, respectively. Isofraxidin (IF) was one possible radio-protector in these 80 drugs. This study investigated the radio-protective role of IF, a Coumarin compound, in human leukemia cell lines, for the first time...
June 2014: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/23708058/the-oxidative-damages-caused-by-ultraviolet-radiation-type-c-uvc-to-a-tropical-rodent-funambulus-pennanti-role-of-melatonin
#8
Soumik Goswami, Shweta Sharma, Chandana Haldar
Data suggests that UV radiation causes oxidative damage of the cells due to the release of inflammatory cytokines which in turn generates reactive oxygen species (ROS) that damages lipids, proteins and DNA. On the other hand, melatonin a potent antioxidant from the pineal gland under most of the conditions acts as a free radical scavenger. Our data suggests that melatonin pre-treatment (s.c. injections) significantly protected the diurnal squirrels from oxidative damages caused by UVC irradiation of 1528 mJ cm(-2) that induced suppression of delayed type hypersensitivity (DTH) responses...
August 5, 2013: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/23314761/dose-dependent-response-of-tumor-vasculature-to-radiation-therapy-in-combination-with-sunitinib-depicted-by-three-dimensional-high-frequency-power-doppler-ultrasound
#9
Ahmed El Kaffas, Anoja Giles, Gregory J Czarnota
PURPOSE: Large doses of radiation (8-20 Gy) preferentially target tumor vasculature. This vascular response is suggested to regulate tumor response to radiotherapy. Here, we investigate the relative contributions of direct cell killing by radiation versus tumor cell death due to radiation effects on the vasculature. We also examine Sunitinib's mechanism of action as a tumor radiosensitizer. EXPERIMENTAL DESIGN: MDA-MB-231 xenografts were treated with radiation doses of 2-16 Gy alone, or in combination with bFGF (endothelial radio-protector) or Sunitinib as pharmacological modulators of the vasculature...
April 2013: Angiogenesis
https://www.readbyqxmd.com/read/23116308/recent-progress-in-studying-curcumin-and-its-nano-preparations-for-cancer-therapy
#10
REVIEW
Jieying Liu, Siyuan Chen, Li Lv, Lei Song, Shengrong Guo, Shengtang Huang
A hydrophobic polyphenol compound extracted from turmeric, curcumin has been widely utilized as traditional medicines for centuries in China and India. Over the last decades, because of its low toxicity, extensive studies have been focused on its physicochemical properties and pharmacological activities on various diseases, such as cancer, cardio-vascular disease, inflammatory bowel, wound healing, Alzheimer's disease, rheumatoid arthritis, and diabetes. In particular, bioactivities of curcumin as an effective chemopreventive agent, chemo-/radio-sensitizer for tumor cells, and chemo-/radio-protector for normal organs, are of extraordinary research interests in the literature...
2013: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/21751492/-the-protective-effects-of-sb203580-against-mortality-and-radiation-induced-intestinal-injury-of-mice
#11
Jian-hui Chang, Heng Zhang, Fang-xia Guan, Yue-ying Wang, De-guan Li, Hong-ying Wu, Cheng-chun Wang, Chang-hui Zhou, Zhi-bin Zhai, Lu Lu, Xiao-chun Wang, Qi Hou, Ai-min Meng
This study is to investigate the protective effects of the SB203580 against radiation induced mortality and intestinal injury of mice. A total of 67 male C57BL/6 mice (20.0-22.0 g) were matched according to body weight and randomly assigned to one of three groups: control, total body irradiation exposure (IR, 7.2 Gy) only, and IR (7.2 Gy) + SB203580 (15 mg x kg(-1)). 30 days survival rate was observed in the experiment. In intestinal injury experiment, the expression levels of caspase-3, Ki67, p53 and p-p38 were assayed in the mice intestine crypts...
April 2011: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
https://www.readbyqxmd.com/read/21605919/n-acetyl-cysteine-reduces-chromosomal-dna-damage-in-circulating-lymphocytes-during-cardiac-catheterization-procedures-a-pilot-study
#12
Maria Grazia Andreassi, Angelo Cioppa, Samantha Manfredi, Maria Giovanna Neri, Ilenia Foffa, Eugenio Picano
BACKGROUND: N-acetylcysteine (NAC) is considered a promising radio-protector for its antioxidant and anticarcinogenic properties. We examined the ability of NAC to confer protection against radiation-induced chromosomal DNA damage during cardiac catheterization procedures. METHODS: Sixty-five patients (52 males, age 64.4 ± 11.9 years) undergoing invasive cardiovascular procedures (peripheral transluminal angioplasty, n=45; cardiac resynchronization therapy, n=15 and ablation therapy n=5) were enrolled: 35 patients (26 males, age 63...
November 15, 2012: International Journal of Cardiology
https://www.readbyqxmd.com/read/19481594/chebulagic-acid-a-cox-lox-dual-inhibitor-isolated-from-the-fruits-of-terminalia-chebula-retz-induces-apoptosis-in-colo-205-cell-line
#13
D Bharat Reddy, T C M Reddy, G Jyotsna, Satish Sharan, Nalini Priya, V Lakshmipathi, Pallu Reddanna
ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia chebula has an esteemed origin in Indian mythology; its fruits are used to treat many diseases such as digestive, diabetes, colic pain, chronic cough, sore throat, asthma, etc. AIM OF THE STUDY: The water or ethanolic extracts of the fruits were reported to have anti-oxidant, anti-inflammatory, anti-cancer and radio-protector properties. The present study is to isolate and identify the compounds that inhibit COX and 5-LOX, the key enzymes involved in inflammation and carcinogenesis...
July 30, 2009: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/19056532/effect-of-infliximab-on-the-levels-of-tnf-alpha-and-tgf-beta-in-the-whole-blood-cultures-of-irradiated-patients
#14
RANDOMIZED CONTROLLED TRIAL
Elzbieta Staroslawska, Krzysztof J Czarnocki, Maria Koziol-Montewka, Helena Donica, Agnieszka Magrys
TGF-beta is supposed to be the major cytokine responsible for post-radiation fibrosis of healthy tissues and actively modifies post-radiation changes. The growth of TGF-beta level induces the expression of collagen synthesis gene which triggers off the production of fibrosis of hyaline membranes. The main purpose of this study was to discover the way and methods of reducing post-radiation damage of normal tissues and provide an adequate scientific justification for using Infliximab as an effective radio protector in the neoplasm radiotherapy...
2008: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/17537599/irradiation-of-human-insulin-in-aqueous-solution-first-step-towards-radiosterilization
#15
Hélène Terryn, Aubert Maquille, Chantal Houée-Levin, Bernard Tilquin
The degradation of irradiated human insulin in aqueous solutions was investigated in order to protect the protein against ionizing radiation. The influence of the drug concentration, excipients and irradiation temperature were studied. Aqueous solutions at pH 2 were irradiated by gamma rays or by accelerated electrons. Two different high-performance liquid chromatography (HPLC) methods were used: reverse-phase high-performance liquid chromatography (RP-HPLC)/UV and size exclusion liquid chromatography (SEC/UV) to investigate both the fragmentation and the formation of higher molecular weight proteins...
October 1, 2007: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/16860592/protection-against-radiation-oxidative-damage-in-mice-by-triphala
#16
T Sandhya, K M Lathika, B N Pandey, H N Bhilwade, R C Chaubey, K I Priyadarsini, K P Mishra
Protection against whole body gamma-irradiation (WBI) of Swiss mice orally fed with Triphala (TPL), an Ayurvedic formulation, in terms of mortality of irradiated animals as well as DNA damage at cellular level has been investigated. It was found that radiation induced mortality was reduced by 60% in mice fed with TPL (1g/kg body weight/day) orally for 7 days prior to WBI at 7.5 Gy followed by post-irradiation feeding for 7 days. An increase in xanthine oxidoreductase activity and decrease in superoxide dismutase activity was observed in the intestine of mice exposed to WBI, which, however, reverted back to those levels of sham-irradiated controls, when animals were fed with TPL for 7 days prior to irradiation...
October 10, 2006: Mutation Research
https://www.readbyqxmd.com/read/16320718/-morphological-observation-of-amifostine-s-protective-effect-on-radiation-induced-early-middle-ear-injury
#17
Zhongchun Chen, Shengzi Wang, Shuyi Wang, Qingfang Cheng, Shenbin Lu
OBJECTIVE: To assess the radio-protective effect of amifostine on the middle ear in animal models by observing the morphological changes of middle ear mucosa. METHOD: Adult guinea pigs (n=38) were divided into the radiation group, the radiation-amifostine group and the control group. The first two groups were exposed to total 45 Gy of Gamma radiation which was administered to the right ear of each guinea pig with 3.0 Gy/fraction, 5 times per week, using a cobalt-60 machine...
August 2005: Lin Chuang Er Bi Yan Hou Ke za Zhi, Journal of Clinical Otorhinolaryngology
https://www.readbyqxmd.com/read/15304956/detection-of-gamma-irradiation-induced-dna-damage-and-radioprotection-of-compounds-in-yeast-using-comet-assay
#18
COMPARATIVE STUDY
P S Nemavarkar, B K Chourasia, K Pasupathy
The single cell gel electrophoresis assay (SCGE), a very rapid and sensitive method, has been applied to follow gamma-irradiation induced DNA damage in budding yeast, Saccharomyces cerevisiae. Spheroplasting the gamma-irradiated yeast cells by enzyme glusulase, before subjecting them to electrophoresis, resulted in a well-defined appearance of comets. Yeast comets look quite different from mammalian comets. A linear relationship was observed between the doses of irradiation and the tail moments of comets. These studies were extended to follow the action of known radio-protectors, i...
June 2004: Journal of Radiation Research
https://www.readbyqxmd.com/read/14483385/-2-methyl-piperazine-dithioformate-a-new-liver-and-radio-protector
#19
V PALMA, G GALLI, S GARATTINI, R PAOLETTI, R VERTUA
No abstract text is available yet for this article.
November 1961: Arzneimittel-Forschung
https://www.readbyqxmd.com/read/13925430/-the-combination-of-adenosinetriphosphate-and-diphosphopyridine-nucleotide-as-a-radio-protector-of-embryonal-cells
#20
L VERGA, F COUCOURDE
No abstract text is available yet for this article.
December 15, 1961: Bollettino Della Società Italiana di Biologia Sperimentale
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