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https://www.readbyqxmd.com/read/27911110/mannose-binding-lectin-deficiency-in-brazilian-patients-with-spondyloarthritis
#1
Thelma L Skare, Renato Nisihara, Juliana Z Cieslinski, João O Zeni, Henrique N Rasera, Iara Messias-Reason, Shirley R R Utiyama
BACKGROUND: Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE: To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical profile of these diseases. METHODS: We studied 89 SpA patients and 89 healthy individuals, paired for age and gender. MBL serum levels were measured by ELISA test...
December 2, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27909080/ankylosing-spondylitis-versus-nonradiographic-axial-spondyloarthritis-comparison-of-tumor-necrosis-factor-inhibitor-effectiveness-and-effect-of-hla-b27-status-an-observational-cohort-study-from-the-nationwide-danbio-registry
#2
Bente Glintborg, Inge J Sørensen, Mikkel Østergaard, Lene Dreyer, Abdiweli A Mohamoud, Niels S Krogh, Oliver Hendricks, Lis S Andersen, Johnny L Raun, Marcin R Kowalski, Laura Danielsen, Randi Pelck, Henrik Nordin, Jens K Pedersen, Dorte G A Kraus, Susan R Christensen, Inger M J Hansen, Jakob Esbesen, Annette Schlemmer, Anne G Loft, Nabil Al Chaer, Lone Salomonsen, Merete L Hetland
OBJECTIVE: To compare baseline disease activity and treatment effectiveness in biologic-naive patients with nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) who initiate tumor necrosis factor inhibitor (TNFi) treatment and to study the role of potential confounders (e.g., HLA-B27 status). METHODS: Observational cohort study based on prospectively registered data in the nationwide DANBIO registry. We used Kaplan-Meier plots, Cox, and logistic regression analyses to study the effect of diagnosis (nr-axSpA vs AS) and potential confounders (sex/age/start yr/HLA-B27/disease duration/TNFi-type/smoking/baseline disease activity) on TNFi adherence and response [e...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27908311/obesity-decreases-clinical-efficacy-and-levels-of-adalimumab-in-patients-with-ankylosing-spondylitis
#3
José Rosas, Francisca Llinares-Tello, José Miguel Senabre-Gallego, Xavier Barber-Vallés, Gregorio Santos-Soler, Esteban Salas-Heredia, Ana Pons Bas, Catalina Cano Pérez, Mario García-Carrasco
OBJECTIVES: Obesity can be a factor that affects response to anti-TNF drugs. However, studies on patients with ankylosing spondylitis (AS) are rare. We aimed to determine whether obesity affects serum levels of adalimumab (ADL), and immunogenicity and clinical efficacy of the drug in patients with AS. METHODS: A cross-sectional study on 57 patients with axial AS receiving ADL was conducted. They received DMARD per standard of care at their rheumatologist's discretion...
November 13, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27899002/in-axial-spondyloarthritis-never-smokers-ex-smokers-and-current-smokers-show-a-gradient-of-increasing-disease-severity-results-from-the-scotland-registry-for-ankylosing-spondylitis-siras
#4
Gareth T Jones, Tiara Ratz, Linda E Dean, Gary J Macfarlane, Fabiola Atzeni
Objectives To examine the relationship between smoking, smoking cessation, and disease characteristics/quality of life (QoL) in spondyloarthritis. Methods The Scotland Registry for Ankylosing Spondylitis collects data from clinically diagnosed patients with spondyloarthritis. Clinical data, including Bath Ankylosing Spondylitis indices of disease activity (BASDAI) and function (BASFI), was obtained from medical records. Postal questionnaires provided information on smoking status and QoL (Ankylosing Spondylitis QoL questionnaire; ASQoL)...
November 29, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27887637/clinical-improvement-and-reduction-in-serum-calprotectin-levels-after-an-intensive-exercise-programme-for-patients-with-ankylosing-spondylitis-and-non-radiographic-axial-spondyloarthritis
#5
Andrea Levitova, Hana Hulejova, Maja Spiritovic, Karel Pavelka, Ladislav Senolt, Marketa Husakova
BACKGROUND: The efficacy of exercise therapy for ankylosing spondylitis (AS) is well-documented, but dearth of information is for non-radiographic axial spondyloarthritis (nr-axSpA). Biomarkers like serum calprotectin, interleukins IL-6, IL-17 and tumour necrosis factor (TNF)-α may reflect the disease activity of axial spondyloarthritis (axSpA). In this study, we investigated clinical and laboratory parameters of both axSpA subgroups in response to intensive physical exercise. METHODS: Altogether, 46 patients with axSpA, characterised according to the Assessment of SpondyloArthritis International Society criteria as having nr-axSpA or AS underwent 6-month exercise programme...
November 25, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27881910/low-dose-modified-release-prednisone-in-axial-spondyloarthritis-3-month-efficacy-and-tolerability
#6
Francesca Bandinelli, Francesco Scazzariello, Emanuela Pimenta da Fonseca, Mittermayer Barreto Santiago, Claudio Marcassa, Francesca Nacci, Marco Matucci Cerinic
BACKGROUND: Oral glucocorticoids (GCs) have been shown to be effective in reducing the inflammatory symptoms of rheumatoid arthritis, but their use is not supported by evidence in spondyloarthritis (SpA). Modified-release (MR) oral prednisone taken at bedtime has been shown to be more effective than immediate-release prednisone taken in the morning. The efficacy of low-dose MR prednisolone in patients with SpA is unknown. PATIENTS AND METHODS: This single-center cohort study retrospectively assessed the effectiveness and safety of 12-week low-dose MR prednisone (5 mg daily, bedtime administration) in GC-naïve adult patients with symptomatic axial SpA...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27869581/physical-activity-in-ankylosing-spondylitis-evaluation-and-analysis-of-an-ehealth-tool
#7
Jess Shelagh Tyrrell, Clare Helen Redshaw
BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory condition characterised by spinal arthritis and exercise is often recommended to reduce the symptoms and improve mobility. However, very little evidence exists for the value of exercise in AS. OBJECTIVES: Firstly, this pilot study aimed to evaluate an eHealth tool, the AS Observer, specifically designed to monitor symptoms, quality of life and physical activity in AS, in terms of patient experience and suitability in generating data for epidemiological studies...
July 4, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/27865027/assessment-of-active-and-inactive-sacroiliitis-in-patients-with-ankylosing-spondylitis-using-quantitative-dynamic-contrast-enhanced-mri
#8
Mengchao Zhang, Le Zhou, Ning Huang, Hong Zeng, Songyan Liu, Lin Liu
PURPOSE: To investigate the feasibility of using quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to differentiate the active and inactive stage of sacroiliitis and the correlation between quantitative parameters and disease activity as measured by clinical scores. MATERIALS AND METHODS: Forty-two patients with ankylosing spondylitis underwent DCE-MRI on a 3.0T MRI unit. According to the results of the blood sedimentation rate (ESR), C-reactive protein (CRP), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the patients were grouped into inactive and active groups...
November 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27860306/validity-and-reliability-of-the-health-assessment-questionnaire-among-patients-with-spondyloarthritis-in-singapore
#9
Yu Heng Kwan, Warren Fong, Nai Lee Lui, Si Ting Yong, Yin Bun Cheung, Rahul Malhotra, Julian Thumboo, Truls Østbye
AIM: The Health Assessment Questionnaire (HAQ) is a popular tool used to measure disability. Few studies have assessed its psychometric properties in patients with spondyloarthritis (SpA). We therefore aimed to assess the reliability and validity of the HAQ in patients with SpA in Singapore. METHOD: Cross-sectional data from a registry of 196 patients with SpA recruited from a dedicated tertiary referral clinic in Singapore from 2011 to 2014 was used. Analyses were guided by the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) framework...
November 14, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27852321/work-productivity-is-associated-with-disease-activity-and-functional-ability-in-italian-patients-with-early-axial-spondyloarthritis-an-observational-study-from-the-space-cohort
#10
Manouk de Hooge, Roberta Ramonda, Mariagrazia Lorenzin, Paola Frallonardo, Leonardo Punzi, Augusta Ortolan, Andrea Doria
BACKGROUND: Spondyloarthritis often affects young people, typically in their working years. The aim of our study was to investigate work productivity and its relationship with disease activity and physical functioning in Italian patients with axial spondyloarthritis (axSpA) with chronic back pain (CBP) for ≥3 months and ≤2 years, and onset  < 45 years of age. METHODS: Baseline absenteeism, presenteeism, work productivity loss (assessed by the Work Productivity and Activity Impairment questionnaire (WPAI)), and disease activity (assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)/Ankylosing Spondylitis Disease Activity Score (ASDAS)) and functional ability (assessed by the Bath Ankylosing Spondylitis Disease Functional Index (BASFI)) of patients with axSpA (rheumatologist's diagnosis) included in the Italian section of the Spondyloarthritis Caught Early (SPACE) cohort were collected...
November 16, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27837263/the-effectiveness-of-specific-exercise-types-on-cardiopulmonary-functions-in-patients-with-ankylosing-spondylitis-a-systematic-review
#11
REVIEW
Ismail Saracoglu, Gamze Kurt, Eda Ozge Okur, Emrah Afsar, Gulce Kallem Seyyar, Bilge Basakci Calik, Ferruh Taspinar
The aim of this review was to assess the effectiveness of specific exercise types on pulmonary functions, aerobic and functional capacity in patients with ankylosing spondylitis (AS). A systematic search of Cochrane Database of Systematic Review, MEDLINE (EBSCO), Physiotherapy Evidence Database (PEDro), CINAHL (EBSCO), PUBMED, AMED, EMBASE (OVID) was conducted in January 2016. The outcome measures were spirometric measurements, chest expansion, 6 minute walk distance (6MWD), pVO2, Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)...
November 11, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27816498/increased-expression-of-tipe2-mrna-in-pbmcs-of-patients-with-ankylosing-spondylitis-is-negatively-associated-with-the-disease-severity
#12
Peiqing Zhao, Lianqing Wang, Xinxin Xiang, Xiaowei Zhang, Qiaoli Zhai, Xifa Wu, Tao Li
Ankylosing spondylitis (AS) is an autoimmune disease and characterized by chronic inflammatory arthritis. Tumor necrosis factor α induced protein-8 like-2 (TIPE2) is responsible for maintaining immune homeostasis by inhibiting the secretion of inflammatory cytokines in the condition of inflammation. However, whether TIPE2 participates in the development of AS remains unknown. In this study, we measured the mRNA expression of TIPE2 and TIPE1 in peripheral blood mononuclear cells (PBMCs) from 45 AS patients and 40 healthy controls by qRT-PCR...
November 2, 2016: Human Immunology
https://www.readbyqxmd.com/read/27815702/increasing-smoking-intensity-is-associated-with-increased-disease-activity-in-axial-spondyloarthritis
#13
Sizheng Zhao, Benjamin Challoner, Mohammed Khattak, Robert J Moots, Nicola J Goodson
A history of ever-smoking appears to be associated with a more severe disease phenotype in axial spondyloarthritis (axSpA). However, evidence is sparse for the effect of increased smoking exposure on disease outcomes or whether smoking reduction or cessation improves outcomes. The aim of this study was to explore whether a dose-response relationship exists between pack-years and disease activity and functional impairment in axSpA. Consecutive patients meeting ASAS criteria for axial SpA were recruited from a spondyloarthritis service...
November 4, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27803139/physical-function-and-spinal-mobility-remain-stable-despite-radiographic-spinal-progression-in-patients-with-ankylosing-spondylitis-treated-with-tnf-%C3%AE-inhibitors-for-up-to-10-years
#14
Denis Poddubnyy, Aleksandra Fedorova, Joachim Listing, Hildrun Haibel, Xenofon Baraliakos, Jürgen Braun, Joachim Sieper
OBJECTIVE: The aim of the study was to investigate the effect of radiographic spinal progression and disease activity on function and spinal mobility in patients with ankylosing spondylitis (AS) treated with tumor necrosis factor-α (TNF-α) inhibitors for up to 10 years. METHODS: Patients with AS who participated in 2 longterm open-label extensions of clinical trials with TNF-α inhibitors (43 receiving infliximab and 17 receiving etanercept) were included in this analysis based on the availability of spinal radiographs performed at baseline and at a later timepoint (yr 2, 4, 6, 8, and 10) during followup...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27800496/serum-hmgb1-serves-as-a-novel-laboratory-indicator-reflecting-disease-activity-and-treatment-response-in-ankylosing-spondylitis-patients
#15
Chenqiong Wang, Ye Miao, Xuefen Wu, Yishu Huang, Mengchen Sun, Yingzi Zhu, Fang Zheng, Wei Sun, Lingli Dong
Objective. High mobility group box 1 (HMGB1) is a late inflammatory factor participating in the pathogenesis of various autoimmune and inflammatory diseases. In the current study, we analyzed the association between serum levels of HMGB1 and clinical features of AS patients before and during treatment. Methods. Serum HMGB1 was detected in 147 AS patients and 61 healthy controls using ELISA. We evaluated the association between HMGB1 and extra-articular manifestations as well as disease severity indices. Among these AS patients, 41 patients received close follow-up at 1, 3, and 6 months after treatment...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27782869/assessment-of-semaphorin-3a-and-its-role-in-bone-remodelling-in-a-group-of-ankylosing-spondylitis-patients
#16
Fabio Massimo Perrotta, Fulvia Ceccarelli, Cristiana Barbati, Tania Colasanti, Monica Montepaone, Cristiano Alessandri, Guido Valesini, Ennio Lubrano
OBJECTIVES: Several molecules are involved in the pathogenesis of new bone formation in ankylosing spondylitis (AS). The aim of the present study was to evaluate serum levels of semaphoring 3A in AS and to investigate any correlations with radiographic damage, disease activity, function and treatment. METHODS: AS patients who fulfilled the modified New York criteria were enrolled for this study. Healthy subjects were also enrolled as control group. BASDAI, ASDAS-CRP, BASMI, BASFI, patients and physician VAS, C-reactive protein and erythrocyte sedimentation rate were evaluated at baseline visit...
October 26, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27749225/flare-in-axial-spondyloarthritis-investigation-of-meaningful-changes-in-symptomatic-outcome-measures
#17
Maxime Dougados, Emily Wood, Laure Gossec, Désirée van der Heijde, Isabelle Logeart
OBJECTIVES: To assess symptomatic outcomes associated with flare after discontinuation of non-steroidal anti-inflammatory drugs (NSAIDs) in axial spondyloarthritis (axSpA). METHODS: Patients with NSAID-refractory axSpA discontinued NSAIDs, restarted if symptoms recurred, and self-recorded Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). 75th percentiles were calculated for changes in BASDAI total and components from NSAID discontinuation to resumption...
September 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27749222/long-term-drug-survival-and-clinical-effectiveness-of-etanercept-treatment-in-patients-with-ankylosing-spondylitis-in-daily-clinical-practice
#18
Suzanne Arends, Elisabeth Brouwer, Monique Efde, Eveline van der Veer, Hendrika Bootsma, Freke Wink, Anneke Spoorenberg
OBJECTIVES: Randomised controlled trials and open-label extension studies have demonstrated the clinical efficacy and safety of tumour necrosis factor-alpha (TNF-α) blocking therapy in pre-selected study patients with ankylosing spondylitis (AS). Our aim was to investigate the 7-year drug survival and clinical effectiveness of etanercept treatment in AS patients in daily clinical practice. METHODS: Consecutive AS patients from the prospective observational GLAS cohort who started etanercept because of active disease were included and evaluated over 7 years according to a fixed protocol...
October 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27747533/predictors-of-atherosclerosis-in-ankylosing-spondylitis
#19
Inderjeet Verma, Pawan Krishan, Ashit Syngle
OBJECTIVE: Accelerated atherosclerosis associated with an enhanced inflammatory state, which characterizes ankylosing spondylitis (AS), is the leading cause of increased cardiovascular risk. The objective of this study was to assess carotid intima-media thickness (CIMT) as a surrogate for subclinical atherosclerosis in AS patients and its possible correlation with disease-related clinical parameters. METHODS: We performed a prospective study of 30 consecutive patients meeting modified New York criteria for AS compared to 25 controls matched for age and sex...
December 2015: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27747513/real-life-experience-of-first-course-of-anti-tnf-treatment-in-ankylosing-spondylitis-patients-in-brazil
#20
Marina Amaral de Ávila de Machado, Alessandra Maciel Almeida, Adriana Maria Kakehasi, Francisco de Assis Acurcio
INTRODUCTION: In Brazil, patients with ankylosing spondylitis (AS) have access to free-of-charge comprehensive therapeutic care through the Brazilian National Health System. We collected prospective data on patients with AS receiving anti-tumor necrosis factor (anti-TNF) therapy through the Brazilian National Health System in Belo Horizonte City in order to evaluate the effectiveness, quality-of-life outcomes and safety of this therapy. METHODS: This was a prospective study that included 87 patients receiving their first course of anti-TNF agents (adalimumab, etanercept or infliximab)...
June 2016: Rheumatology and Therapy
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