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https://www.readbyqxmd.com/read/29768347/a-retrospective-study-of-alendronate-for-the-treatment-of-ankylosing-spondylitis
#1
Gang Li, Chang-An Lv, Li Tian, Lian-Jin Jin, Wei Zhao
This retrospective study assessed the effect of alendronate for treating patients with ankylosing spondylitis (AS).Eighty-six patients with AS were included in this retrospective study, and were divided into 2 groups. Forty-six patients in the intervention group received alendronate plus vitamin D (400 mg/day) and calcium (500 mg/day), while 40 patients in the control group received vitamin D and calcium only, the same dose as the intervention group. The primary outcome included bone densitometry. The secondary outcomes consisted of quality of life, measured by Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire, disease activity, measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and functional status, measured by Bath Ankylosing Spondylitis Functional Index (BASFI), as well as the adverse events (AEs)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29754330/gender-differences-in-axial-spondyloarthritis-women-are-not-so-lucky
#2
REVIEW
T Rusman, R F van Vollenhoven, I E van der Horst-Bruinsma
PURPOSE OF REVIEW: Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gender distribution. The purpose of this review is to aggregate the existing data on gender differences in axSpA in order to increase the awareness that female axSpA patients are still under-recognized...
May 12, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29751976/high-prevalence-of-hidradenitis-suppurativa-symptoms-in-axial-spondyloarthritis-patients-a-possible-new-extra-articular-manifestation
#3
Angelique Rondags, Suzanne Arends, Freke R Wink, Barbara Horváth, Anneke Spoorenberg
BACKGROUND: Spondyloarthritis (SpA), a chronic inflammatory, rheumatic disease, and hidradenitis suppurativa (HS), a chronic, debilitating, inflammatory skin disease, share several clinical and pathophysiological features, such as the association with inflammatory bowel disease and elevated cytokine levels IL-17 and TNF-α. Recently, SpA was reported to be more prevalent (2.3-28.2%) in patients with HS than in the general population. Conversely, the prevalence of HS in SpA is not exactly known...
March 20, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29750059/serum-il-6-correlates-with-axial-mobility-index-bath-ankylosing-spondylitis-metrology-index-in-brazilian-patients-with-ankylosing-spondylitis
#4
Cristina F Rabelo, Talita Siara Almeida Baptista, Laura Esteves Petersen, Moisés Evandro Bauer, Mauro Waldemar Keiserman, Henrique Luiz Staub
Introduction: Ankylosing spondylitis (AS) is a chronic disease featuring axial changes, peripheral arthritis and systemic involvement. Proinflammatory cytokines are probably involved in AS pathogenesis. The relationship of circulating cytokines with instruments of AS evaluation is an open field of research. Objective: The aim of this study was to compare serum levels of cytokines in AS patients and healthy controls, and search for correlations of cytokines with indexes of disease activity and quality of life...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29745878/should-over-treatment-of-axial-spondyloarthritis-with-biologics-remain-a-concern-after-the-issue-of-the-new-asas-criteria-data-from-regisponserbio-spanish-register-of-biological-therapy-in-spondyloarthritides
#5
Mireia Moreno, Jordi Gratacós, Victoria Navarro-Compán, Eugenio de Miguel, Pilar Font, Teresa Clavaguera, Luis Francisco Linares, Beatriz Joven, Xavier Juanola
OBJECTIVES: To study whether disease status at treatment initiation has changed after the issue of the ASAS classification criteria. METHODS: REGISPONSERBIO registers patients with axial spondyloarthritis (axSpA) on biological treatment since 2013. It includes patients starting biological treatment (incident) or already on biological therapies (prevalent). Patients in both groups were compared in terms of: age at disease onset and at treatment start, disease duration, gender, HLA-B27, body mass index (BMI), BASDAI, BASFI, C-reactive protein, ESR, metrological data, ASQoL, WAPAI, extra-articular manifestations, comorbidities, radiological study, type of biological treatment and concomitant treatments...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29743324/spondyloarthritis-in-the-democratic-republic-of-the-congo-a-prospective-hospital-based-study
#6
Pierrot Lebughe, Kurt de Vlam, Rene Westhovens, Jean-Marie Mbuyi-Muamba, Jean Jacques Malemba
OBJECTIVES: To determine the spectrum of spondyloarthritis (SpA) in outpatients with symptoms of rheumatism attending two rheumatology practices in the Democratic Republic of the Congo. DESIGN: A descriptive prospective multicentre outpatient study. SETTING: The present study analysed 6 months data (from 1 December 2012 till 31 May 2013). PARTICIPANTS: Nine hundred and eighty-four consecutive outpatients were studied...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29735967/clinical-efficacy-of-modified-yanghe-decoction-in-ankylosing-spondylitis-a-randomized-controlled-trial
#7
Yiquan Wang, Xiaoli Xiao
BACKGROUND This study evaluated the effects of Modified Yanghe Decoction on pain, disease activity, and functional capacity, and its safety in subjects with ankylosing spondylitis (AS). MATERIAL AND METHODS A randomized, controlled study of subjects with AS was conducted over 8 weeks to compare the efficacy of the Modified Yanghe Decoction to celecoxib-sulfasalazine therapy. Subjects were evaluated at visit 1, and at weeks 4 and 8 of the trial. The Bath ankylosing spondylitis disease activity index (BASDAI), nocturnal back pain (NBP), total back pain (TBP), patient global disease activity (PGDA), the Bath ankylosing spondylitis functional index (BASFI), and the Bath ankylosing spondylitis metrology index (BASMI) were measured at each time point...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29731839/high-frequency-of-circulating-follicular-helper-t-cells-is-correlated-with-b-cell-subtypes-in-patients-with-ankylosing-spondylitis
#8
Siqi Long, Li Ma, Dongsheng Wang, Xianwen Shang
T follicular helper (Tfh) cells are known to support effector B cells and enhance autoimmunity; however, the association between the Tfh cells and B cells in ankylosing spondylitis (AS) is unclear. The aim of the present study was to measure the frequency of circulating cluster of differentiation (CD)4+ C-X-C chemokine receptor type 5 (CXCR5)+ Tfh cells and B cell subtypes in peripheral blood from patients with AS, and evaluate the correlation of these factors. Percentages of peripheral blood circulating CD4+ CXCR5+ Tfh cells and B cell subtypes were measured via flow cytometry and the disease activity of individual patients was measured using the Bath AS Disease Activity Index (BASDAI)...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29714437/the-association-of-neuropathic-pain-and-disease-activity-functional-level-and-quality-of-life-in-patients-with-ankylosing-spondylitis-a-cross-sectional-study
#9
Duygu Geler-Külcü, Sevilay Batıbay, Gülcan Öztürk, Nilgün Mesci
Background/aim: Increased neuropathic pain (NP) symptoms are seen in rheumatologic diseases such as fibromyalgia, osteoarthritis, and rheumatoid arthritis, but no studies have demonstrated a relationship between ankylosing spondylitis (AS) and NP except for a brain imaging study. The aim of this study was to estimate the presence of NP in patients with AS and to investigate how NP was related to disease activity, functional status, and quality of life. Materials and methods: A total of 100 AS patients (71 males and 29 females; median age: 37 years, range: 18–71 years) were included in the study...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713968/association-of-neuropathic-like-pain-characteristics-with-clinical-and-radiographic-features-in-patients-with-ankylosing-spondylitis
#10
Jung-Hye Choi, Sang-Heon Lee, Hae-Rim Kim, Kyung-Ann Lee
Ankylosing spondylitis (AS) is a chronic, progressive, and inflammatory disorder and causes chronic back pain. It is not unusual for patients with AS to have symptoms similar to neuropathic pain. We aimed to investigate the neuropathic pain (NeP) component in patients with AS using the painDETECT questionnaire (PD-Q) and to assess the relation between NeP and the disease characteristics of AS. A single-center prospective study was performed, including 105 patients. Patients with AS completed three questionnaires: PD-Q, Beck Depression Inventory (BDI), and Euro Quality of Life (EQ-5D) questionnaires...
April 30, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29691772/evaluation-of-quality-of-life-in-patients-with-axial-spondyloarthritis-and-its-association-with-disease-activity-functionality-mobility-and-structural-damage
#11
Clementina López-Medina, Juan L Garrido-Castro, Juan Castro-Jiménez, Cristina González-Navas, Jerusalem Calvo-Gutiérrez, M Carmen Castro-Villegas, Rafaela Ortega-Castro, Alejandro Escudero-Contreras, Pilar Font-Ugalde, Eduardo Collantes-Estévez
To evaluate quality of life (QoL) in patients with axial spondyloarthritis (axSpA) and its association with disease activity, functionality, structural damage, and spinal mobility, using patient-reported outcomes. This was an observational, cross-sectional, and single-center study in which 100 consecutive patients with axSpA were included. We obtained from all patients' sociodemographic data and values related to disease activity, functionality, structural damage, mobility, and quality of life. The Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) was considered as the primary outcome...
April 24, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29690706/-the-analysis-of-clinical-characteristics-and-disease-activity-in-ankylosing-spondylitis-patients-with-hyperuircemia
#12
X J Zhang, X M Cui, R Y Chen, H T Sun, J J Zhou, L D Jiang
Objective: to investigate the clinical characteristics and disease activity in ankylosing spondylitis (AS) patients with hyperuricemia. Method: Laboratory tests, magnetic resonance imaging, disease activity and functional index of AS patients from Fudan University Zhongshan Hospital were collected. T test, square test were applied to investigate the difference between AS patients with hyperuricemia and AS patients with normal serum uric acid in clinical characteristics and disease activity in AS patients. Result: Among all the AS patients, 23...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29665824/inflammatory-back-pain-in-psoriatic-arthritis-is-significantly-more-responsive-to-corticosteroids-compared-to-back-pain-in-ankylosing-spondylitis-a-prospective-open-labelled-controlled-pilot-study
#13
Muhammad Haroon, Muddassar Ahmad, Muhammad Nouman Baig, Olivia Mason, John Rice, Oliver FitzGerald
BACKGROUND: The efficacy of corticosteroids in patients with psoriatic arthritis (PsA) and inflammatory back pain has not been studied to date. In this controlled trial, we aimed to investigate the comparative performance of corticosteroids in patients with active axial-PsA (AxPsA) versus those with active ankylosing spondylitis (AS). METHODS: Patients with AxPsA and AS (naïve to biologic therapies), who not only had clinically active disease, but also had bone marrow oedema on magnetic resonance imaging of the sacroiliac joints, were recruited...
April 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29657148/the-prevalence-of-renal-impairment-in-patients-with-spondyloarthritis-results-from-the-international-asas-comospa-study
#14
Marion Couderc, Bruno Pereira, Anna Molto, Aurélien Tiple, Martin Soubrier, Maxime Dougados
OBJECTIVE: To assess the prevalence and association of renal dysfunction in patients with spondyloarthritis (SpA). METHODS: The ASAS-COMOSPA (Assessment of Spondyloarthritis international Society-COMOrbidities in SPondyloArthritis) was an international study (22 participating countries from 4 continents) investigating comorbidities in SpA. Renal function was assessed based on estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease equation...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29625390/dysfunction-of-regulatory-t-cells-in-patients-with-ankylosing-spondylitis-is-associated-with-a-loss-of-tim-3
#15
Mingfei Wang, Chengyi Liu, Allen Bond, Jun Yang, Xu Zhou, Jian Wang, Bin Ji
An expansion of regulatory T cells (Tregs) in ankylosing spondylitis (AS) was observed. However, AS patients continue to exhibit aberrant inflammation. In this study, we collected PBMCs from 26 AS patients and 26 healthy controls, and investigated the functional capacity of Treg cells from these subjects. In AS patients, the frequency of CD4+ CD25+ Foxp3+ CD127- Treg cells was slightly increased compared to healthy controls, but the level of Foxp3 MFI in AS patient CD4+ CD25+ Foxp3+ CD127- Treg cells was significantly lower than that in healthy control CD4+ CD25+ Foxp3+ CD127- Treg cells...
April 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29615661/microbiota-composition-may-predict-anti-tnf-alpha-response-in-spondyloarthritis-patients-an-exploratory-study
#16
Thomas Bazin, Katarzyna B Hooks, Thomas Barnetche, Marie-Elise Truchetet, Raphaël Enaud, Christophe Richez, Maxime Dougados, Christophe Hubert, Aurélien Barré, Macha Nikolski, Thierry Schaeverbeke
Spondyloarthritis (SpA) pathophysiology remains largely unknown. While the association with genetic factors has been established for decades, the influence of gut microbiota is only an emerging direction of research. Despite the remarkable efficacy of anti-TNF-α treatments, non-responders are frequent and no predictive factors of patient outcome have been identified. Our objective was to investigate the modifications of intestinal microbiota composition in patients suffering from SpA three months after an anti-TNF-α treatment...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29609207/open-label-non-mandatory-transitioning-from-originator-etanercept-to-biosimilar-sb4-6-month-results-from-a-controlled-cohort-study
#17
Lieke Tweehuysen, Victor Jb Huiskes, Bart Jf van den Bemt, Johanna E Vriezekolk, Steven Teerenstra, Frank Hj van den Hoogen, Cornelia H van den Ende, Alfons A den Broeder
OBJECTIVE: To evaluate the effects of non-mandatory transitioning from originator etanercept (ENB) to biosimilar etanercept (SB4) on drug survival and effectiveness in a controlled cohort study of patients with an inflammatory rheumatic disease. METHODS: In 2016, 642 ENB-treated patients were asked to transition to SB4 by a structured communication strategy with opt-out option. Consenting patients were eligible for the current study [BIO-SPAN]. ENB-treated patients in 2014 were recruited as historical cohort...
April 2, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29593551/retinal-vessel-diameters-and-physical-activity-in-patients-with-mild-to-moderate-rheumatic-disease-without-cardiovascular-comorbidities
#18
Arne Deiseroth, Thimo Marcin, Colette Berger, Denis Infanger, Juliane Schäfer, Bettina Bannert, Arno Schmidt-Trucksäss, Reinhard E Voll, Diego Kyburz, Henner Hanssen
Objectives: Low-grade systemic inflammation is responsible for atherosclerotic lesions in patients with rheumatic diseases. Vascular dysfunction is a precursor of atherosclerosis and can be improved by physical activity (PA). Our aim was to asses micro- and macrovascular function as well as PA and cardiorespiratory fitness (CRF) in patients with rheumatic diseases in the absence of cardiovascular (CV) comorbidities compared to controls. Methods: Fifty-one patients without CV comorbidities were compared to 35 controls...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29589132/smoking-quantity-determines-disease-activity-and-function-in-chinese-patients-with-ankylosing-spondylitis
#19
Hui Zhang, Wei Wan, Jing Liu, Shengming Dai, Yaohong Zou, Qiaoxia Qian, Yue Ding, Xia Xu, Hengdong Ji, Hongjun He, Qi Zhu, Chengde Yang, Shuang Ye, Lindi Jiang, Jianping Tang, Qiang Tong, Dongyi He, Dongbao Zhao, Yuan Li, Yanyun Ma, Jingru Zhou, Zhendong Mei, Xiangxiang Chen, Ziyu Yuan, Juan Zhang, Xiaofeng Wang, Yajun Yang, Li Jin, Ying Gao, Xiaodong Zhou, John D Reveille, Hejian Zou, Jiucun Wang
The objective of this study was to systemically and comprehensively evaluate the associations between smoking and disease outcomes in patients with ankylosing spondylitis (AS). Information on smoking, clinical features, and sociodemographic characteristics was collected by a questionnaire administered directly to the patient. Group differences were analyzed by t test or chi-square test. Logistic regression analysis was conducted with the Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), C-reactive protein, and erythrocyte sedimentation rate as the dependent variables and different stratification of smoking duration, smoking intensity, and cumulative smoking as independent variables...
March 27, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29560939/-effectiveness-of-the-tenoxicam-in-patients-with-ankylosing-spondylitis
#20
I Z Gaydukova, A V Aparkina, E V Khondkaryan, A P Rebrov
AIM: To study the changes in pain syndrome and its characteristic in patients with ankylosing spondylitis (AS) who received tenoxicam after non-effective treatment with NSAIDs on the 'on-demand' basis. MATERIAL AND METHODS: Forty patients with AS, who had BASDAI ≥4.0 at baseline and after 52 weeks of NSAIDs on the 'on-demand' basis, were randomized into 2 groups: 30 patients were prescribed 20 mg of tenoxicam oraly per day, 10 patients continued previous therapy...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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