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https://www.readbyqxmd.com/read/29793176/non-ldl-dyslipidemia-is-prevalent-in-the-young-and-determined-by-lifestyle-factors-and-age-the-lifelines-cohort
#1
Jeroen K de Vries, Jan W Balder, Michelle J Pena, Petra Denig, Andries J Smit
BACKGROUND AND AIMS: Non-LDL dyslipidemia (NLD) confers cardiovascular risk, and prevalence rates appear to be high in elderly populations. Small cohorts have identified several lifestyle, anthropometric, and medical factors associated with NLD. We aimed to assess sex- and age-specific prevalence of NLD in a contemporary population cohort (n = 167 729), and to identify independent determinants of NLD, focusing on lifestyle, anthropometric, and medical factors. METHODS: The prevalence of NLD was assessed per 10-year age intervals in adults without cardiovascular disease not using lipid-modifying drugs from the Dutch LifeLines cohort...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29792380/alirocumab-as-add-on-therapy-to-statins-current-evidence-and-clinical-potential
#2
Johann Auer, Robert Berent
Atherosclerotic cardiovascular diseases (ASCVDs) are associated with a substantial mortality, physical morbidity, and mental disability. Elevated plasma low-density lipoprotein cholesterol (LDL-C) levels play a major role in the pathophysiology of ASCVDs. Statins have been shown to reduce ASCVD risk and associated events and are recommended as first-line therapy for treatment of hypercholesterolemia by current international guidelines. The key issue is to attain guideline-recommended LDL-C levels (below 70 mg/dl) for patients at very high cardiovascular risk...
May 1, 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/29792202/the-effects-of-a-lifestyle-focused-text-messaging-intervention-on-adherence-to-dietary-guideline-recommendations-in-patients-with-coronary-heart-disease-an-analysis-of-the-text-me-study
#3
Karla Santo, Karice Hyun, Laura de Keizer, Aravinda Thiagalingam, Graham S Hillis, John Chalmers, Julie Redfern, Clara K Chow
BACKGROUND: A healthy diet is an important component of secondary prevention of coronary heart disease (CHD). The TEXT ME study was a randomised clinical trial of people with CHD that were randomised into standard care or a text-message programme in addition to standard care. This analysis aimed to: 1) assess the effects of the intervention onadherence to the dietary guideline recommendations; 2) assess the consistency of effect across sub-groups; and 3) assess whether adherence to the dietary guideline recommendations mediated the improvements in objective clinical outcomes...
May 23, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29792133/impact-of-collaborative-shared-medical-appointments-on-diabetes-outcomes-in-a-family-medicine-clinic
#4
Melody L Hartzler, McKenzie Shenk, Julie Williams, James Schoen, Thomas Dunn, Douglas Anderson
Purpose The purpose of this study is to evaluate the impact of a collaborative diabetes shared medical appointment on patient outcomes in an urban family medicine practice. Methods Fifty-nine patients were enrolled to participate in multiple shared medical appointments (SMAs) over 12 months. Baseline data included hemoglobin (A1C), lipids, systolic blood pressure (SBP), weight, adherence to American Diabetes Association (ADA) guidelines, and surveys, including the Problem Areas in Diabetes (PAID-2) scale and the Spoken Knowledge in Low Literacy in Diabetes Scale (SKILLD)...
May 1, 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29791169/-epicardial-fat-and-osteoprotegerin-does-a-mutual-relation-exist-pilot-study
#5
Markéta Sovová, Eliška Sovová, Jana Zapletalová, Markéta Kaletová, David Stejskal, Milan Sova, Michal Konečný, Vlastimil Procházka, Drahomíra Vrzalová, Lea Zarivnijová
INTRODUCTION: Epicardial fat (EPI) plays important role in development of metabolic and cardiovascular diseases. According to population studies EPI represents independent risk factor of cardiovascular diseases (CVD) and also for neoplasms. Osteoprotegerin (OPG) is a glycoprotein which have role in regulation of immune and cardiovascular systems. High serum levels of OPG are connected with high cardiovascular risk. The aim of our study was to evaluate possible correlation between EPI and OPG level in asymptomatic relatives of patients with CVD...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29783064/aerobic-resistance-or-combined-training-a-systematic-review-and-meta-analysis-of-exercise-to-reduce-cardiovascular-risk-in-adults-with-metabolic-syndrome
#6
Michael A Wewege, Jeanette M Thom, Kerry-Anne Rye, Belinda J Parmenter
BACKGROUND AND AIMS: Exercise is beneficial to individuals with metabolic syndrome (MetS). An understudied group, who represent the majority of the MetS population, are individuals who have not developed diabetes. This review examined aerobic, resistance and combined (aerobic + resistance) exercise for cardiovascular risk factors in MetS without diabetes. METHODS: Eight electronic databases were searched up to September 2017 for randomised controlled trials >4 weeks in duration that compared an exercise intervention to the non-exercise control in MetS without diabetes...
May 3, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29782556/the-effects-of-probiotics-supplementation-on-metabolic-health-in-pregnant-women-an-evidence-based-meta-analysis
#7
Jia Zheng, Qianyun Feng, Sheng Zheng, Xinhua Xiao
The prevalence of maternal obesity and gestational diabetes mellitus (GDM) is increasing rapidly. Probiotics supplementation have been shown to improve metabolic health in humans. In our study, we aimed to evaluate the effects of probiotics supplementation on metabolic health and pregnancy complications in pregnant women. The literature search, data extraction and quality assessment were performed, and data were synthesized in accordance with standardized guidelines. Ten randomized clinical trials with eligible data were included in our meta-analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29779453/association-between-thyroid-dysfunction-and-lipid-profiles-differs-according-to-age-and-gender-results-from-the-korean-national-health-and-nutrition-examination-survey
#8
Hye-Seon Oh, Hyemi Kwon, Jonghwa Ahn, Eyun Song, Suyeon Park, Mijin Kim, Minkyu Han, MinJi Jeon, Won Gu Kim, Won Bae Kim, YoungKee Shong, Eun-Jung Rhee, Tae Yong Kim
<i>Background</i> Lipid profiles of men and women change differently during the aging process. Guidelines recommend that dyslipidemia patients should consider screening for hypothyroidism without consideration of age or gender. <i>Methods</i> Data from the sixth Korean National Health and Nutrition Examination were used. A total of 4,275 participants without thyroid disease and without a past history of dyslipidemia or dyslipidemia medication were evaluated. We analyzed the association between thyroid dysfunction and lipid profiles (total cholesterol [TC], low-dense lipoprotein cholesterol [LDLC], and triglyceride [TG]) by age and gender...
May 19, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29774988/differences-in-primary-cardiovascular-disease-prevention-between-the-2013-and-2016-cholesterol-guidelines-and-impact-of-the-2017-hypertension-guideline-in-the-united-states
#9
Brent M Egan, Jiexiang Li, Robert A Davis, Kevin A Fiscella, Jonathan N Tobin, Daniel W Jones, Angelo Sinopoli
The US Preventive Services Task Force cholesterol guideline recommended statins for fewer adults than the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline by setting a higher 10-year atherosclerotic cardiovascular disease threshold (≥10.0% vs ≥7.5%) and requiring concomitant diabetes mellitus, hypertension, dyslipidemia, or cigarette smoking. The 2017 ACC/AHA hypertension guideline lowered the hypertension threshold, increasing 2016 guideline statin-eligible adults. Cross-sectional data on US adults aged 40 to 75 years enabled estimated numbers for the 2013 guideline and 2016 guideline with hypertension thresholds of ≥140/≥90 mm Hg and ≥130/80 mm Hg, respectively, on: (1) untreated, statin-eligible adults for primary atherosclerotic cardiovascular disease prevention (25...
May 18, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29762264/achieving-guideline-driven-high-intensity-statin-dose-in-cardiac-rehabilitation-patients-with-coronary-artery-disease
#10
Jonathan Lin, Alexandra Banathy, Carla Winters, Lars Andersen, Cindy Hudson, Heidi Testa, Joy Reardon, Peter Alagona
PURPOSE: The 2013 American College of Cardiology/American Heart Association Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults recommends high-intensity statin therapy in patients aged ≤75 y with clinical coronary artery disease (CAD). The effectiveness of cardiac rehabilitation (CR) in lipid management and guideline adherence is unknown. The purpose of this study is to determine whether CR participation affects guideline-driven achievement for statin use...
May 12, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29759108/a-western-dietary-pattern-is-prospectively-associated-with-cardio-metabolic-traits-and-incidence-of-the-metabolic-syndrome
#11
Isabel Drake, Emily Sonestedt, Ulrika Ericson, Peter Wallström, Marju Orho-Melander
The aim of this study was to derive dietary patterns associated with cardio-metabolic traits and to examine whether these predict prospective changes in these traits and incidence of the metabolic syndrome (iMetS). Subjects from the Malmö Diet and Cancer Study cardiovascular cohort without cardio-metabolic disease and related drug treatments at baseline (n 4071; aged 45-67 years, 40 % men) were included. We applied reduced rank regression on thirty-eight foods to derive patterns that explain variation in response variables measured at baseline (waist circumference, TAG, HDL- and LDL-cholesterol, systolic and diastolic blood pressure, fasting glucose and insulin)...
May 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29753234/effect-of-short-term-hazelnut-consumption-on-dna-damage-and-oxidized-ldl-in-children-and-adolescents-with-primary-hyperlipidemia-a-randomized-controlled-trial
#12
Federica Guaraldi, Valeria Deon, Cristian Del Bo', Stefano Vendrame, Marisa Porrini, Patrizia Riso, Ornella Guardamagna
Children with primary hyperlipidemia are prone to develop premature atherosclerosis, possibly associated with increased oxidative stress. Nutritional therapy is the primary strategy in the treatment of hyperlipidemia and associated conditions. Dietary interventions with bioactive-rich foods, such as nuts, may contribute to the modulation of both lipid profile and the oxidative/antioxidant status. Our study aimed to assess the impact of a dietary intervention with hazelnuts on selected oxidative stress markers in children and adolescents with primary hyperlipidemia...
March 20, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29751285/improving-identification-and-management-of-familial-hypercholesterolaemia-in-primary-care-pre-and-post-intervention-study
#13
Stephen Weng, Joe Kai, Jennifer Tranter, Jo Leonardi-Bee, Nadeem Qureshi
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) is a major cause of premature heart disease but remains unrecognised in most patients. This study investigated if a systematic primary care-based approach to identify and manage possible FH improves recommended best clinical practice. METHODS: Pre- and post-intervention study in six UK general practices (population 45,033), which invited patients with total cholesterol >7.5 mmol/L to be assessed for possible FH...
April 30, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29749101/understanding-patient-adherence-and-concerns-with-statins-and-medication-discussions-with-physicians-action-a-survey-on-the-patient-perspective-of-dialogue-with-healthcare-providers-regarding-statin-therapy
#14
Eliot A Brinton
BACKGROUND: Statin therapy is used first-line for cholesterol lowering and prevention of atherosclerotic cardiovascular disease (CVD), but side effects and the potential for drug-drug interactions may complicate its use. Provider-patient communication is essential for shared decision-making, which, in turn, is recommended by guidelines to reduce or overcome these challenges. Unfortunately, relatively little is known about provider-patient communication surrounding statin use. METHOD: We conducted an online survey of 5,014 patients, U...
May 10, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29748356/variation-in-lipid-lowering-therapy-use-in-patients-with-low-density-lipoprotein-cholesterol-%C3%A2-190-mg-dl-insights-from-the-national-cardiovascular-data-registry-practice-innovation-and-clinical-excellence-registry
#15
Salim S Virani, Kevin F Kennedy, Julia M Akeroyd, Pamela B Morris, Vera A Bittner, Frederick A Masoudi, Neil J Stone, Laura A Petersen, Christie M Ballantyne
BACKGROUND: Patients with low-density lipoprotein cholesterol (LDL-C) ≥190 mg/dL are at high risk of atherosclerotic cardiovascular disease events. Treatment guidelines recommend intensive treatment in these patients. Variation in the use of lipid-lowering therapies (LLTs) in these patients in a national sample of cardiology practices is not known. METHODS AND RESULTS: Using data from the American College of Cardiology National Cardiovascular Data Registry-Practice Innovation and Clinical Excellence registry, we assessed the proportion of patients with LDL-C ≥190 mg/dL (n=49 447) receiving statin, high-intensity statin, LLT associated with ≥50% LDL-C lowering, ezetimibe, or a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor between January 2013 and December 2016...
May 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29741558/effect-of-a-high-egg-diet-on-cardiometabolic-risk-factors-in-people-with-type-2-diabetes-the-diabetes-and-egg-diabegg-study-randomized-weight-loss-and-follow-up-phase
#16
Nicholas R Fuller, Amanda Sainsbury, Ian D Caterson, Gareth Denyer, Mackenzie Fong, James Gerofi, Chloris Leung, Namson S Lau, Kathryn H Williams, Andrzej S Januszewski, Alicia J Jenkins, Tania P Markovic
Background: Some country guidelines recommend that people with type 2 diabetes (T2D) limit their consumption of eggs and cholesterol. Our previously published 3-mo weight-maintenance study showed that a high-egg (≥12 eggs/wk) diet compared with a low-egg diet (<2 eggs/wk) did not have adverse effects on cardiometabolic risk factors in adults with T2D. Objective: The current study follows the previously published 3-mo weight-maintenance study and assessed the effects of the high-egg compared with the low-egg diets as part of a 3-mo weight-loss period, followed by a 6-mo follow-up period for a total duration of 12 mo...
May 7, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29735587/high-dose-versus-low-dose-pitavastatin-in-japanese-patients-with-stable-coronary-artery-disease-real-cad-a-randomized-superiority-trial
#17
Isao Taguchi, Satoshi Iimuro, Hiroshi Iwata, Hiroaki Takashima, Mitsuru Abe, Eisuke Amiya, Takanori Ogawa, Yukio Ozaki, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Tsutomu Yamazaki, Hiroshi Ito, Yutaka Otsuji, Kazuo Kimura, Jun Takahashi, Atsushi Hirayama, Hiroyoshi Yokoi, Kazuo Kitagawa, Takao Urabe, Yasushi Okada, Yasuo Terayama, Kazunori Toyoda, Takehiko Nagao, Masayasu Matsumoto, Yasuo Ohashi, Tetsuji Kaneko, Retsu Fujita, Hiroshi Ohtsu, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Teruo Inoue, Masunori Matsuzaki, Ryozo Nagai
BACKGROUND: Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS: In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese patients with stable coronary artery disease who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were randomized in a 1-to-1 fashion to high-dose (pitavastatin 4 mg/d; n=6526) or low-dose (pitavastatin 1 mg/d; n=6528) statin therapy...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29735484/effect-of-an-sirna-therapeutic-targeting-pcsk9-on-atherogenic-lipoproteins-pre-specified-secondary-end-points-in-orion-1
#18
Kausik K Ray, Robert M Stoekenbroek, David Kallend, Lawrence A Leiter, Ulf Landmesser, R Scott Wright, Peter Wijngaard, John J Kastelein
Background -The ORION-1 trial demonstrated that inclisiran, a small interfering RNA (siRNA) therapeutic that targets PCSK9 mRNA within hepatocytes, produces significant LDL-C reduction. The effects of inclisiran on other lipids are less well described. Methods -ORION-1 was a phase 2 trial assessing 6 different inclisiran dosing regimens vs placebo. Participants with elevated LDL-C despite receiving maximally tolerated statin therapy received a single- (200, 300 or 500mg) or two-dose starting regimen (100, 200 or 300mg on days 1 and 90) of inclisiran or placebo...
May 7, 2018: Circulation
https://www.readbyqxmd.com/read/29733433/statin-therapy-on-glycemic-control-in-type-2-diabetic-patients-a-network-meta-analysis
#19
J Y Cui, R R Zhou, S Han, T S Wang, L Q Wang, X H Xie
WHAT IS KNOWN AND OBJECTIVE: Statins are the cornerstone of primary and secondary prevention of cardiovascular diseases (CVDs) and are effective for the prevention of vascular events in diabetic patients. Diabetes mellitus is an important risk factor for CVDs .The majority of patients with diabetes mellitus benefits from statin therapy. According to the recent clinical guidelines of the American College of Cardiology and the American Heart Association, moderate-intensity or high-intensity statin therapy should be used as the primary prevention for individuals with diabetes mellitus, aged between 40 and 75 years and with low-density lipoprotein cholesterol (LDL-C) from 70 to 189 mg/dL...
May 7, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29730084/effectiveness-of-nurse-led-patient-centered-care-behavioral-risk-modification-on-secondary-prevention-of-coronary-heart-disease-a-systematic-review
#20
REVIEW
Chung-Yan Chiang, Kai-Chow Choi, Ka-Ming Ho, Sau-Fung Yu
BACKGROUND: Despite establishment of advocacies centered on using patient-centered care to improve disease-related behavioral changes and health outcomes, studies have seldom discussed incorporation of patient-centered care concept in the design of secondary cardiac prevention. OBJECTIVES: This review aimed to identify, appraise, and examine existing evidence on the effectiveness of nurse-led patient-centered care for secondary cardiac prevention in patients with coronary heart disease...
April 22, 2018: International Journal of Nursing Studies
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