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https://www.readbyqxmd.com/read/29141201/cardiovascular-risk-and-statin-eligibility-of-young-adults-after-an-myocardial-infarction-partners-young-mi-registry
#1
Avinainder Singh, Bradley L Collins, Ankur Gupta, Amber Fatima, Arman Qamar, David Biery, Julio Baez, Mary Cawley, Josh Klein, Jon Hainer, Jorge Plutzky, Christopher P Cannon, Khurram Nasir, Marcelo F Di Carli, Deepak L Bhatt, Ron Blankstein
BACKGROUND: Despite significant progress in primary prevention, the rate of MI has not declined in young adults. OBJECTIVES: We aimed to evaluate statin eligibility based on the 2013 American College of Cardiology / American Heart Association (ACC/AHA) guidelines for treatment of blood cholesterol and 2016 United States Preventive Services Task Force (USPSTF) recommendations for statin use in primary prevention in a cohort of adults who experienced a first-time myocardial infarction (MI) at a young age...
November 8, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29137927/the-cholesterol-lowering-effect-of-statins-is-potentiated-by-whole-grains-intake-the-polish-norwegian-study-pons
#2
Georgeta D Vaidean, Marta Manczuk, Sandeep S Vansal, Jacqueline Griffith
BACKGROUND: Hypercholesterolemia treatment guidelines emphasize an adequate whole grains (WG) intake, alone or complementary to pharmacological treatment. We conducted this study to compare the prevalence of adequate WG intake and levels of blood lipids according to the statin/WG intake status. METHODS: This cross-sectional analysis of a community-based study included 12,754 men and women, age 45-64. Statin use over past 30days was recorded by trained nurses. Food intake over past 12months was assessed by a validated food-frequency questionnaire...
November 11, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29130272/effects-of-guideline-and-formulary-changes-on-statin-prescribing-in-the-veterans-affairs
#3
Adam A Markovitz, Rob G Holleman, Timothy P Hofer, Eve A Kerr, Mandi L Klamerus, Jeremy B Sussman
OBJECTIVE: To compare the effects of two sequential policy changes-the addition of a high-potency statin to the Department of Veterans Affairs (VA) formulary and the release of the American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines-on VA provider prescribing. DATA SOURCES/STUDY SETTING: Retrospective analysis of 1,100,682 VA patients, 2011-2016. STUDY DESIGN: Interrupted time-series analysis of changes in prescribing of moderate-to-high-intensity statins among high-risk patients and across high-risk subgroups...
December 2017: Health Services Research
https://www.readbyqxmd.com/read/29130053/treatment-gaps-found-in-the-management-of-type-2-diabetes-at-a-community-health-centre-in-johannesburg-south-africa
#4
Yacob Pinchevsky, Neil Butkow, Tobias Chirwa, Frederick Raal
Aims: The management of cardiometabolic goals or "ABCs" (HbA1c, blood pressure (BP), and cholesterol) ultimately determines the morbidity and mortality outcomes in patients with type 2 diabetes mellitus (T2DM). We sought to determine if patients with T2DM attending an urbanized public sector community health centre (CHC) were having their ABCs measured, were treated with appropriate cardioprotective agents and finally, were achieving guideline-based targets. Methods and Results: A cross-sectional record review of 519 patients was conducted between May and August 2015...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29129396/sex-difference-between-target-levels-of-cholesterol-related-parameters-and-post-pci-long-term-clinical-outcomes-from-the-fu-registry
#5
Yuta Matsuoka, Amane Ike, Masahiro Ogawa, Kouki Gondo, Kazuyuki Shirai, Makoto Sugihara, Daisuke Nose, Hiroaki Nishikawa, Atsushi Iwata, Akira Kawamura, Ken Mori, Bo Zhang, Shin'ichiro Yasunaga, Shin-Ichiro Miura, Keijiro Saku
BACKGROUND: Since single lipid parameters are too weak to predict the risk of coronary artery disease, we examined whether the allocation of patients into four groups based on achievement of the target levels set by the Japan Atherosclerosis Guidelines at the time of percutaneous coronary intervention (PCI) would reveal different long-term (5 years) clinical outcomes in males and females. METHODS: The results of a 5-year follow-up study are summarized as FU-Registry, Long-Term Clinical Outcome Results...
November 9, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29129260/lipid-management-in-contemporary-community-practice-results-from-the-provider-assessment-of-lipid-management-palm-registry
#6
Ann Marie Navar, Tracy Y Wang, Shuang Li, Jennifer G Robinson, Anne C Goldberg, Salim Virani, Veronique L Roger, Peter W F Wilson, Joseph Elassal, L Veronica Lee, Eric D Peterson
BACKGROUND: The latest cholesterol guidelines have shifted focus from achieving low-density lipoprotein cholesterol (LDL-C) targets toward statin use and intensity guided by atherosclerotic cardiovascular disease (ASCVD) risk. METHODS: Statin use and intensity were evaluated in 5,905 statin-eligible primary or secondary prevention patients from 138 PALM Registry practices. RESULTS: Overall, 74.7% of eligible adults were on statins; only 42...
November 2017: American Heart Journal
https://www.readbyqxmd.com/read/29122809/eligibility-for-pcsk9-inhibitors-according-to-american-college-of-cardiology-acc-and-european-society-of-cardiology-european-atherosclerosis-society-esc-eas-guidelines-after-acute-coronary-syndromes
#7
Baris Gencer, Konstantinos C Koskinas, Lorenz Räber, Alexios Karagiannis, David Nanchen, Reto Auer, David Carballo, Sebastian Carballo, Roland Klingenberg, Dik Heg, Christian M Matter, Thomas F Lüscher, Nicolas Rodondi, François Mach, Stephan Windecker
BACKGROUND: The American College of Cardiology (ACC) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) have recently published recommendations for the use of proprotein convertase subtilisin/kexin-9 (PCSK9) inhibitors in situations of very high risk. We aim to assess in the real world the suitability of PCSK9 inhibitors for acute coronary syndromes. METHODS AND RESULTS: We analyzed a prospective Swiss cohort of 2023 patients hospitalized for acute coronary syndromes between 2009 and 2014 with available data for low-density lipoprotein cholesterol and lipid-lowering therapy at 1 year...
November 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29117276/clinical-efficacy-and-safety-of-evolocumab-in-high-risk-patients-receiving-a-statin-secondary-analysis-of-patients-with-low-ldl-cholesterol-levels-and-in-those-already-receiving-a-maximal-potency-statin-in-a-randomized-clinical-trial
#8
Robert P Giugliano, Anthony Keech, Sabina A Murphy, Kurt Huber, S Lale Tokgozoglu, Basil S Lewis, Jorge Ferreira, Armando Lira Pineda, Ransi Somaratne, Peter S Sever, Terje R Pedersen, Marc S Sabatine
Importance: Current guidelines for atherosclerotic cardiovascular disease focus on high-intensity statins and targeting or using a threshold low-density lipoprotein cholesterol (LDL-C) level of less than 70 mg/dL for the highest-risk patients. Whether further reduction of LDL-C beyond these boundaries would be beneficial is unknown. Objective: To compare outcomes of evolocumab vs placebo in patients with stable atherosclerotic cardiovascular disease and a baseline LDL-C of less than 70 mg/dL and in those receiving background treatment with a maximal-potency statin...
November 8, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29116404/review-of-cardiometabolic-effects-of-prescription-omega-3-fatty-acids
#9
REVIEW
Megan F Burke, Frances M Burke, Daniel E Soffer
PURPOSE OF REVIEW: Populations with significant dietary fish intake tend to have lower cardiovascular (CV) risk and demonstrable physiologic differences including lower lipid/lipoprotein levels and other direct and indirect effects on the arterial wall and inhibiting factors that promote atherosclerosis. Treatment with high doses of pharmacologic-grade omega-3 fatty acid (n-3FA) supplements achieves significant reductions in triglycerides (TG), non-high-density lipoprotein- (non-HDL-) and TG-rich lipoprotein- (TRL-) cholesterol levels...
November 7, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29108840/use-of-the-coronary-artery-calcium-score-in-discussion-of-initiation-of-statin-therapy-in-primary-prevention
#10
Erin D Michos, Michael J Blaha, Roger S Blumenthal
Clinical guidelines for instituting pharmacotherapy for the primary prevention of atherosclerotic cardiovascular disease (ASCVD), specifically lipid management and aspirin, have long been based on absolute risk. However, lipid management in the current era remains challenging to both patients and clinicians in the setting of somewhat discordant recommendations from various organizations. All guidelines endorse the use of statins for primary prevention for those at sufficient absolute risk, and treatment recommendations are generally "risk-based" rather than exclusively targeting specific low-density lipoprotein cholesterol levels...
November 3, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29104037/critical-review-of-2016-acc-guidelines-on-therapies-for-cholesterol-lowering-with-reference-to-laboratory-testing
#11
REVIEW
Stanley S Levinson
INTRODUCTION: This review discusses new guidelines that were released in 2016 and 2017 for assessing risk of coronary disease (ASCVD) and treatments and that appear to have replaced the 2013 guidelines which superseded the National Cholesterol Education Program Adult Treatment Panel Guidelines (ATP). To put the new guidelines in prospective, I briefly review the history of prior guidelines. The newest guidelines seem to support the idea that elevated LDL cholesterol (C) is a cause of ASCVD...
November 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29103310/comparison-of-adherence-to-the-2013-acc-aha-cholesterol-guideline-in-a-teaching-versus-nonteaching-outpatient-clinic
#12
Angela Cheng-Lai, Jessica Snead, Christina Ng, Caroline Verges, Philip Chung
BACKGROUND: Little information is available regarding prescribers' adherence rate to the 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guideline, especially that from a teaching versus a nonteaching setting. OBJECTIVES: We aim to evaluate adherence rates to the 2013 ACC/AHA cholesterol guideline in a teaching versus a nonteaching practice site. In addition, the impact of a pharmacist-led seminar on adherence rate to the guideline was assessed...
November 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29096861/current-insights-into-the-german-lipoprotein-apheresis-registry-glar-almost-5-years-on
#13
V J J Schettler, C L Neumann, C Peter, T Zimmermann, U Julius, E Roeseler, F Heigl, P Grützmacher, H Blume
BACKGROUND: In recent years the Federal Joint Committee (G-BA), a paramount decision-making body of the German health care system required a reassessment of the approval of chronic lipoprotein apheresis therapy for regular reimbursement. Since 2005 an interdisciplinary German apheresis working group has been established by members of both German Societies of Nephrology. In 2009 the working group completed the indication for lipoprotein apheresis with respect to current cardiovascular guidelines and current scientific knowledge for the registry...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29096835/rationale-and-design-of-multiselect-a-european-multicenter-study-on-the-effect-of-lipoprotein-a-elimination-by-lipoprotein-apheresis-on-cardiovascular-outcomes
#14
Bernd Hohenstein, Ulrich Julius, Peter Lansberg, Beate Jaeger, Klaus-Peter Mellwig, Norbert Weiss, Xina Graehlert, Ingo Roeder, Wolfgang Ramlow
BACKGROUND: Dyslipidemia is a well-known risk factor for atherosclerosis and subsequent cardiovascular disease (CVD). While low density lipoprotein cholesterol (LDL-C) is well-established and taken into consideration for risk management and therapy, lipoprotein(a) is another established CVD risk factor frequently not undergoing screening due to a lack of medical treatment options. For patients suffering from CVD due to massive elevation of Lp(a) in presence of normal LDL-C levels, lipoprotein apheresis is the only available treatment option...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29095052/current-european-guidelines-for-management-of-cardiovascular-disease-is-medical-treatment-in-nearly-half-a-population-realistic
#15
Johan L Vinther, Rikke K Jacobsen, Torben Jørgensen
Background Health checks of the general population are widely used to prevent cardiovascular diseases, but are the current clinical guidelines from the European Society of Cardiology (ESC) suitable for screening the general population? Design A cross-sectional, population-based study of 978 men and women aged 40-65 years examined in 2010-2011 was used to estimate the proportion of the general Danish population fulfilling the criteria from the clinical guidelines from the ESC on medical treatment and lifestyle intervention to prevent cardiovascular disease...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29093432/european-society-of-cardiology-esc-annual-congress-report-from-barcelona-2017
#16
Kimio Satoh, Jun Takahashi, Yasuharu Matsumoto, Shunsuke Tatebe, Tatsuo Aoki, Yoku Kikuchi, Kiyotaka Hao, Kazuma Ohyama, Masamichi Nogi, Akira Suda, Shintaro Kasahara, Koichi Sato, Sadamitsu Ichijo, Hiroaki Shimokawa
From August 26th to 30th, the 2017 Annual Congress of the European Society of Cardiology (ESC 2017) was held in Barcelona, Spain. Despite the terrorism tradegy just before the ESC congress, the congress attracted many medical professionals from all over the world to discuss the recent topics in cardiovascular medicine in more than 500 sessions, including COMPASS (Cardiovascular OutcoMes for People using Anticoagulation StrategieS Trial), CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study), and ORION (which assessed the effect of a novel siRNA inhibitor to PCSK9 on reductions in low-density lipoprotein cholesterol)...
November 2, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29092883/a-systematic-review-and-meta-analysis-of-nutrition-therapy-compared-with-dietary-advice-in-patients-with-type-2-diabetes
#17
Grith Møller, Henning Keinke Andersen, Ole Snorgaard
Background: Despite recommendations, many patients with type 2 diabetes receive dietary advice from nurses or doctors instead of individualized nutrition therapy (INT) that is provided by a dietitian.Objective: We performed a meta-analysis to compare the effect of INT that is provided by a registered dietitian with the effect of dietary advice that is provided by other healthcare professionals.Design: A systematic review was conducted of Cochrane library databases, EMBASE, CINAHL, and MEDLINE in the period 2004-2017 for guidelines, reviews, and randomized controlled trials (RCTs) that assessed the outcomes glycated hemoglobin (HbA1c), weight, body mass index (BMI; in kg/m(2)), and LDL cholesterol...
November 1, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29083942/regular-aerobic-exercise-and-blood-pressure-in-east-asians-a-meta-analysis-of-randomized-controlled-trials
#18
Yutaka Igarashi, Nobuhiko Akazawa, Seiji Maeda
The aim of this meta-analysis was to evaluate the effects of regular aerobic exercise on blood pressure in East Asians. The inclusion criteria of the randomized controlled trials were healthy East Asian adults, exercise group performing regular aerobic exercise and control group not exercising, and a description of the mean systolic blood pressure or diastolic blood pressure at rest. This study included 31 study groups and 1994 subjects. Pooled changes in blood pressure showed significant reductions (systolic blood pressure: -4...
October 30, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29082640/achieving-ada-ispad-clinical-guideline-goals-is-associated-with-higher-insulin-sensitivity-and-cardiopulmonary-fitness-in-adolescents-with-type-1-diabetes-results-from-resistance-to-insulin-in-type-1-and-type-2-diabetes-resistant-and-effects-of-metformin-on
#19
Petter Bjornstad, Melanie Cree-Green, Amy Baumgartner, Gregory Coe, Yesenia Garcia Reyes, Michal Schäfer, Laura Pyle, Judith G Regensteiner, Jane Eb Reusch, Kristen J Nadeau
OBJECTIVE: Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be associated with better insulin sensitivity (IS) and cardiopulmonary fitness. METHODS: IS was quantified as glucose infusion rate (GIR) from a hyperinsulinemic-euglycemic clamp in youth with type 1 diabetes from the RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) (n = 86) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) (n = 41) cohorts (n = 127; age 15...
October 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29077762/awareness-treatment-and-control-of-dyslipidemia-in-rural-south-africa-the-haalsi-health-and-aging-in-africa-a-longitudinal-study-of-an-indepth-community-in-south-africa-study
#20
Sheridan Reiger, Thiago Veiga Jardim, Shafika Abrahams-Gessel, Nigel J Crowther, Alisha Wade, F Xavier Gomez-Olive, Joshua Salomon, Stephen Tollman, Thomas A Gaziano
Dyslipidemia is a primary driver for chronic cardiovascular conditions and there is no comprehensive literature about its management in South Africa. The objective of this study was to assess the prevalence, awareness, treatment, and control of dyslipidemia in rural South Africa and how they are impacted by different behaviors and non-modifiable factors. To fulfill this objective we recruited for this cohort study adults aged ≥40 years residing in the Agincourt sub-district of Mpumalanga Province. Data collection included socioeconomic and clinical data, anthropometric measures, blood pressure (BP), HIV-status, point-of-care glucose and lipid levels...
2017: PloS One
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