J T Yarrington, W E Hoffman, D Macy, C Hawker
Hypercalcemia, normo- or hypophosphatemia, and increased urinary calcium clearance were observed in 8 dogs with malignant disease consisting of lymphosarcoma (n = 4), lymphogenous leukemia with bone involvement (n = 2), or carcinoma arising in the perianal region (n = 2). Parathyroid glands from these dogs had a normal or atrophic microscopic appearance. Ultrastructurally, the chief cells of the parathyroid glands had small cytoplasmic areas devoid of secretory granules and containing few organelles associated with hormonal synthesis, which is indicative of an inactive phase of the secretory cycle...
February 1981: American Journal of Veterinary Research