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Elizabeth M Winter, Natasha M Appelman-Dijkstra
Context: Parathyroid hormone-related protein (PTH-rP)-induced hypercalcemia or pseudophyperparathyroidism during pregnancy is a condition that can result in serious fetal and maternal complications. Among others, breast tissue might be the cause of this PTH-rP production, in which case medical treatment is possible, as we describe in this case. Setting: A 32-year-old woman presented in the 15th week of pregnancy with massive enlargement of breasts and abdominal pain due to severe hypercalcemia, hypercalciuria, and suppressed PTH...
December 1, 2017: Journal of Clinical Endocrinology and Metabolism
Lillian M Lai, Ralph S Lachman
BACKGROUND: Although mucolipidosis type II has similar metabolic abnormalities to those found in all the mucopolysaccharidoses and mucolipidoses, there are distinctive diagnostic radiographic changes of mucolipidosis II in the perinatal/newborn/infant period. OBJECTIVE: To describe the early characteristic radiographic changes of mucolipidosis II and to document when these changes manifest and resolve. MATERIALS AND METHODS: We retrospectively reviewed radiographs and clinical records of 19 cases of mucolipidosis II from the International Skeletal Dysplasia Registry (1971-present; fetal age to 2½ years)...
November 2016: Pediatric Radiology
R P Willig, N G Mitskevich
Hyperparathyroidism is a rare finding in children. It is a typical sign of vitamin D-deficiency caused by different reasons. It may also be due to calcium wasting syndromes, and it can rarely be induced by adenomas of the parathyroid glands and in parathormone receptor mutations (pseudohyperparathyroidism). A 12-year old Gambian girl living in Hamburg, Germany, was developing abdominal and joint pain. Serum analysis revealed low serum-calcium, significantly elevated parathormone and decreased vitamin D. Immigrant rickets was assumed...
April 2011: Georgian Medical News
Kelly Hopper, Pablo Morales, Anapatricia Garcia, Joseph Wagner
An 8.5-mo-old female rhesus macaque was examined for an apparent lump on the right arm, below the elbow. The macaque showed no signs of pain or discomfort. Examination revealed that the lump was actually a bend in the forearm. Radiography demonstrated that some of the long bones of the animal were bowed. Differential diagnoses included rickets, hyperparathyroidism, pseudohyperparathyroidism, and a growth dysplasia. No other similar abnormalities in animals from that cage or any other enclosure in our large colony were observed...
November 2010: Journal of the American Association for Laboratory Animal Science: JAALAS
Grace David-Vizcarra, Julie Briody, Jenny Ault, Michael Fietz, Janice Fletcher, Ravi Savarirayan, Meredith Wilson, Jim McGill, Matthew Edwards, Craig Munns, Melanie Alcausin, Sara Cathey, David Sillence
AIM: To assess the natural history and impact of the secondary bone disease observed in patients with mucolipidosis (ML) II and III. METHODS: Affected children and adults were ascertained from clinical genetics units around Australia and New Zealand. Diagnoses were confirmed by the National Referral Laboratory in Adelaide. The study encompassed all patients ascertained between 1975 and 2005. Data focussing on biochemical parameters at diagnosis, and longitudinal radiographic findings were sought for each patient...
June 2010: Journal of Paediatrics and Child Health
Katerina Konupcíková, Jirí Masopust, Martin Valis, Jirí Horácek
Fahr's disease is characterized by idiopathic calcification of the basal ganglia and other brain regions. Clinically it may be accompanied by extrapyramidal and behavioural disorders. In Fahr's syndrome, the same pathology is due to another well-defined disease. Calcium/phosphate metabolic disorders, e.g. hypoparathyroidism or pseudohyperparathyroidism, may be involved. Here, we report a case of 62-year-old man presenting with severe dementia but only mild movement disorders and mild calcium metabolism abnormalities...
August 2008: Neuro Endocrinology Letters
No abstract text is available yet for this article.
December 1959: Revista da Associação Médica Brasileira
No abstract text is available yet for this article.
August 7, 1964: Medizinische Klinik
No abstract text is available yet for this article.
November 1964: Cancer
No abstract text is available yet for this article.
February 3, 1962: British Medical Journal (1857-1980)
No abstract text is available yet for this article.
1957: Schweizerische Zeitschrift Für Pathologie und Bakteriologie. Revue Suisse de Pathologie et de Bactériologie
N Leone, W Debernardi-Venon, A Marzano, M Massari, M Rizzetto
Many syndromes reflecting impaired metabolism have been described in association with primary neoplastic diseases. Hypercalcaemia secondary to malignancy without bone metastases and with normal parathyroid glands has been described as "pseudohyperparathyroidism". Differentiation from primary hyperparathyroidism is difficult and care should be taken to exclude an occult malignancy prior to surgical exploration for a parathyroid adenoma. Hypercalcaemia associated with hepatocellular carcinoma is not uncommon...
October 1999: Italian Journal of Gastroenterology and Hepatology
N Frank, J F Hawkins, L L Couëtil, J T Raymond
A 17-year-old pony mare was admitted for evaluation of progressive enlargement of the facial bones during the preceding 9 months. Laboratory testing revealed that the pony had hypercalcemia, hypophosphatemia, high urinary fractional excretion of phosphorus, and high serum concentration of intact parathyroid hormone (185.1 pmol/L; reference range, 0.25 to 2.0 pmol/L). On the basis of these findings, a diagnosis of primary hyperparathyroidism was made by ruling out nutritional secondary hyperparathyroidism, chronic renal disease, and pseudohyperparathyroidism resulting from neoplasia...
January 1, 1998: Journal of the American Veterinary Medical Association
H Mönig, K P Föh, H M Schulte, R Simon
A 25-year-old man was hospitalized because of dyspnoea and retrosternal pain. There were clinical and radiological signs of severe left ventricular failure which within a few hours necessitated artificial ventilation. A year before he had been diagnosed as having pseudohyperparathyroidism and disseminated encephalomyelitis. Administration of calcium and vitamin D was only partially efficacious. On admission the calcium concentration was 1.5 mmol/l. The severe left ventricular failure did not respond adequately to the usual therapeutic measures including artificial ventilation and catecholamines...
September 23, 1994: Deutsche Medizinische Wochenschrift
M A Beebe
No abstract text is available yet for this article.
July 1980: Modern Veterinary Practice
R C Hickey, N A Samaan, G L Jackson
Breast cancer is the malignant neoplasm most commonly associated with hypercalcemia. At the University of Texas M. D. Anderson Hospital, Houston, during the fiscal year 1977 to 1978, of 16,887 patients having calcium determinations, 7.8% had hypercalcemia. From 1969 to 1979, 13 patients had proved and three had presumed primary hyperparathyroidism associated with breast cancer. Two other patients had pseudohyperparathyroidism. Selective neck vein catheterization was used in 17 of the 18 patients and helped localize and confirm the diagnosis of primary hyperparathyroidism...
May 1981: Archives of Surgery
G Lum, S J Deshotels
A logical, systematic approach to the interpretation of diagnostic biochemical profiles in patients with hypercalcemia has been attempted through the use of algorithms (decision trees). A tentative algorithm (ALG-I) and an expanded and modified version (ALG-II) were compared for effectiveness in tests of 80 patients with hypercalcemia at Charity Hospital in New Orleans. The overwhelming majority (69%) of these patients had malignant disease. Comparative performance indicated that the modified algorithm (ALG-II) assigned the correct diagnostic categories in 66% of cases, compared with 53% for ALG-I, but the clinical performance of ALG-I improved (agreement rate of 60%) when it was assumed that patients with malignancy could have coexisting hyperparathyroidism or pseudohyperparathyroidism...
October 1982: American Journal of Clinical Pathology
B Tennant, P Bettleheim, J J Kaneko
Chronic renal failure associated with hypercalcemia and hypophosphatemia was diagnosed in 6 horses. The renal lesions in 5 of the horses were classified as chronic glomerulonephritis and in the sixth, as chronic interstitial nephritis/pyelonephritis. There was no evidence of primary hyperparathyroidism or pseudohyperparathyroidism, thus suggesting that hypercalcemia associated with advanced renal failure in horses is related to a unique role of the equine kidney in calcium homeostasis.
March 15, 1982: Journal of the American Veterinary Medical Association
J T Yarrington, W E Hoffman, D Macy, C Hawker
Hypercalcemia, normo- or hypophosphatemia, and increased urinary calcium clearance were observed in 8 dogs with malignant disease consisting of lymphosarcoma (n = 4), lymphogenous leukemia with bone involvement (n = 2), or carcinoma arising in the perianal region (n = 2). Parathyroid glands from these dogs had a normal or atrophic microscopic appearance. Ultrastructurally, the chief cells of the parathyroid glands had small cytoplasmic areas devoid of secretory granules and containing few organelles associated with hormonal synthesis, which is indicative of an inactive phase of the secretory cycle...
February 1981: American Journal of Veterinary Research
V K Mittal, P Ghosh, R Mohindra
No abstract text is available yet for this article.
February 1983: British Journal of Urology
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