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acute tubulointerstitial nephritis

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https://www.readbyqxmd.com/read/27900940/acute-kidney-injury-in-allopurinol-induced-dress-syndrome-a-case-report-of-concurrent-tubulointerstitial-nephritis-and-kidney-limited-necrotizing-vasculitis%C3%A2
#1
Anthony J Esposito, Ryan C Murphy, Mirna N Toukatly, Osama W Amro, Bryan R Kestenbaum, Behzad Najafian
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal adverse drug reaction with variable renal involvement. We report the case of a man who presented with allopurinol-induced DRESS and acute kidney injury (AKI) requiring hemodialysis. Kidney biopsy revealed eosinophilic tubulointerstitial nephritis and necrotizing vasculitis of the intralobular arteries without systemic markers of vasculitis. After cyclophosphamide and glucocorticoids, his symptoms and AKI resolved. To our knowledge, this is the first case of kidney-limited necrotizing vasculitis, questioning whether a biopsy should be routinely performed in patients with DRESS accompanied by severe AKI...
November 30, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27884304/a-remedy-for-kidney-disease-successfully-alters-the-cold-shock-protein-response-during%C3%A2-inflammation
#2
Sabine Brandt, Peter R Mertens
Kidneys undergoing acute inflammatory responses are characterized by cell infiltration and a cytokinergic milieu. The hazard resides in the perpetuation of inflammation and ensuing fibrosis. In this issue of Kidney International, Wang et al.(4) identify the cold shock Y-box binding protein-1 as the key orchestrator of cell infiltration in experimental tubulointerstitial nephritis following ureteral obstruction. Intriguingly, a small molecule previously designed to interfere with Y-box binding protein-1 interactions mediates an anti-inflammatory response and halts fibrogenesis...
December 2016: Kidney International
https://www.readbyqxmd.com/read/27876011/nivolumab-associated-acute-glomerulonephritis-a-case-report-and-literature-review
#3
Kyungsuk Jung, Xu Zeng, Marijo Bilusic
BACKGROUND: Immune checkpoint inhibitors are changing the landscape of oncology treatment as they are significantly improving treatment for multiple malignancies. Nivolumab, an anti-programmed death 1 antibody, is a US Food and Drug Administration-approved treatment for melanoma, non-small cell lung cancer, and kidney cancer but can result in a spectrum of autoimmune side effects. Adverse effects can occur within any organ system in the body including the colon, lung, liver, endocrine systems, or kidneys...
November 22, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27867184/a-rare-case-of-tubulointerstitial-nephritis-and-uveitis-syndrome-treated-with-a-multi-specialty-approach
#4
Boonkit Purt, Siri Hiremath, Sarah Smith, Sergul Erzurum, Erdal Sarac
BACKGROUND It is important for an ophthalmologist and nephrologist to look for hidden causes of uveitis and nephritis, respectively. Delay in diagnosis leads to increased morbidity and failure to systemically manage the patient results in future recurrence of disease. It is likely that TINU remains underdiagnosed and could potentially account for some of the cases of idiopathic uveitis, especially when greater than 50% of uveitis cases have no identifiable cause. Fewer than 300 cases of tubulointerstitial nephritis and uveitis (TINU) syndrome have been reported...
November 21, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27821911/acute-alloxan-toxicity-causes-granulomatous-tubulointerstitial-nephritis-with-severe-mineralization
#5
Lianshan Zhang, Yui Terayama, Taiki Nishimoto, Yasushi Kodama, Kiyokazu Ozaki
Alloxan had been recognized as having a direct nephrotoxic effect different from its diabetogenic action. We encountered previously unreported granulomatous tubulointerstitial nephritis with severe luminal and interstitial mineralization in one diabetic rat after one week of alloxan administration. Histopathologically, many dilated and occluded proximal and distal tubules were segmentally observed in the cortex and outer medulla. The tubular lumen contained minerals and cell debris. Tubular epithelial cells were degenerated and piled up, and they protruded into the lumen, where they enveloped minerals...
October 2016: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/27781207/reversal-of-gastric-bypass-resolves-hyperoxaluria-and-improves-oxalate-nephropathy-secondary-to-roux-en-y-gastric-bypass
#6
Varun Agrawal, Jonathan B Wilfong, Christopher E Rich, Pamela C Gibson
Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) increases the risk for kidney injury. Medical therapies for hyperoxaluria have limited efficacy. A 65-year-old female was evaluated for acute kidney injury [AKI, serum creatinine (Cr) 2.1 mg/dl, baseline Cr 1.0 mg/dl]. She did not have any urinary or gastrointestinal symptoms or exposure to nephrotoxic agents. Sixteen months prior to this evaluation, she underwent RYGB for morbid obesity. Her examination was unremarkable for hypertension or edema and there was no protein or blood on urine dipstick...
September 2016: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/27737399/acute-tubulointerstitial-nephritis-with-severe-renal-impairment-associated-with-multisystem-igg4-related-disease
#7
Rafael Coimbra Ferreira Beltrame, Maurício Friderichs, Bárbara Rayanne Fior, Pedro Guilherme Schaefer, Gustavo Gomes Thomé, Dirceu Reis da Silva, Elvino José Guardão Barros, Renato Seligman, Francisco Veríssimo Veronese
The IgG4-related disease has a wide clinical spectrum where multiple organs can be affected, and the diagnosis depends on typical histopathological findings and an elevated IgG4 expression in plasma cells in the affected tissue. We describe the clinical presentation and evolution of a patient with acute tubulointerstitial nephritis, severe kidney failure and systemic manifestations such as lymphadenomegaly and chronic pancreatitis. The diagnosis was confirmed by the clinical picture and kidney and lymph node histopathology, in which immunohistochemistry of the lymphoid tissue showed policlonality and increased expression of IgG4, with a IgG4/total IgG ratio > 80%...
July 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/27735794/acute-tubulointerstitial-nephritis-a-case-series-and-long-term-renal-outcomes
#8
Aysel Taktak, Nermin Uncu, Banu Acar, Şemsa Çaycı, Arzu Ensari, Gökçe Gür, Adem Köksoy, Nilgün Çakar
Acute tubulointerstitial nephritis (TIN) is a common cause of acute renal impairment, characterized by the infiltration of inflammatory cells in the interstitium of the kidney. We retrospectively reviewed the medical records of 19 acute TIN patients attended to our Pediatric Nephrology department between April 1999 and April 2014. Nineteen patients (7 boys and 12 girls) were evaluated. The median age was 14 years (range 7-19). Five were diagnosed as TIN histopathologically, fourteen patients were diagnosed as clinically...
November 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27707584/epithelial-mesenchymal-transition-in-pediatric-nephropathies
#9
Laura Penna Rocha, Samuel Cavalcante Xavier, Fernanda Rodrigues Helmo, Juliana Reis Machado, Fernando Silva Ramalho, Marlene Antônia Dos Reis, Rosana Rosa Miranda Corrêa
INTRODUCTION: Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells may express mesenchymal cell markers with subsequent change in their functions, and it may be part of the etiopathogenesis of kidney disease. OBJECTIVE: The aim of this study was to evaluate the immunexpression of some EMT inducers and markers in frequent nephropathies in pediatric patients. METHODS: 59 patients aged 2-18 years old were selected and divided into 6 groups of frequent nephropathies in children and adolescents, as well as one control group...
September 22, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27629781/eosinophilic-tubulointerstitial-nephritis-on-treatment-with-isotretinoin
#10
Gulsah Kaya Aksoy, Mustafa Koyun, Bahar Akkaya, Elif Comak, Atilla Gemici, Sema Akman
: Drug-related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen-year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood urea nitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2...
September 14, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27594450/acute-interstitial-nephritis-in-t-cell-leukemia-in-a-pediatric-patient
#11
Erika Biro, Edit Szikszay, Petronella Pethő-Orosz, László Bigida, György Balla, Tamás Szabó
Acute lymphoid leukemia is the most frequently occurring malignancy in childhood, but acute tubulointerstitial nephritis with associated acute renal failure as the leading manifestation of leukemia is extremely rare. Only a few pediatric cases have been described in the literature. We present a surprising case in which physical examination and initial investigation were not typical for leukemia. Ultrasound showed only modest kidney enlargement while laboratory results indicated acute renal failure. Renal biopsy indicated tubulointerstitial nephritis, and subsequent steroid treatment led to sudden clinical improvement...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27512305/karyomegalic-interstitial-nephropathy-following-ifosfamide-therapy
#12
R Jayasurya, B H Srinivas, M Ponraj, S Haridasan, S Parameswaran, P S Priyamvada
Ifosfamide (IFO), an alkylating agent used for the management of solid organ tumors, can cause reversible Fanconi's syndrome and acute kidney injury. Karyomegalic interstitial nephropathy (KIN) is a rare form of chronic tubulointerstitial nephritis, initially described as a familial nephropathy in adults. So far, four cases of KIN have been reported in pediatric and adolescent population following treatment with IFO. We report a 22-year-old man who developed renal dysfunction following IFO therapy for relapsed Hodgkin's lymphoma...
July 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27504450/coexistence-of-acute-crescent-glomerulonephritis-and-igg4-related-kidney-disease
#13
Zeyuan Lu, Jianyong Yin, Hongda Bao, Qiong Jiao, Huijuan Wu, Rui Wu, Qin Xue, Niansong Wang, Zhigang Zhang, Feng Wang
INTRODUCTION: IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder that may involve almost each organ or system. IgG4-related kidney disease (IgG4-RKD) refers to renal lesions associated with IgG4-RD. The most frequent morphological type of renal lesions is IgG4-related tubulointerstitial nephritis (IgG4-TIN) which is associated with increased IgG4-positive plasma cell infiltration and interstitial fibrosis. CASE REPORT: Herein, we present a rare case with coexisting IgG4-RKD and acute crescent glomerulonephritis with concomitant severe tubulointerstitial lesions instead of classic IgG4-TIN...
May 2016: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/27483570/granulomatous-interstitial-nephritis-associated-with-influenza-a-h1n1-infection-a-case-report
#14
Gordana Milosevski-Lomić, Jasmina Marković-Lipkovski, Mirjana Kostić, Dusan Paripović, Brankica Spasojević-Dimitrijeva, Amira Peco-Antić
INTRODUCTION: The causes of acute tubulointerstitial nephritis can be grouped into four broad categories: medications, infections, immunologic diseases, or idiopathic processes. Here we report a 17-year-old female who developed acute kidney injury (AKI) due to granulomatous interstitial nephritis (GIN) associated with influenza A: H1N1 infection. CASE OUTLINE: The illness presented after two weeks of respiratory tract infection, skin rash and hypermenorrhea. On admission the patient was febrile, with bilateral pedal edema, macular skin rash, and auscultatory finding that suggested pneumonia...
March 2016: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/27437289/synthetic-cannabinoid-induced-acute-tubulointerstitial-nephritis-and-uveitis-syndrome-a-case-report-and-review-of-literature
#15
Ayse Sinangil, Vedat Celik, Alev Kockar, Tevfik Ecder
Tubulointerstitial Nephritis with Uveitis (TINU) syndrome is a rarely seen syndrome. The interstitial nephritis may be with the concurrent uveitis and can also develop before or after uveitis. The syndrome can resolve after elimination of the culprit destructive factors, such as drugs, toxins and immune reaction. Synthetic cannabinoids have emerged as drugs of abuse with increasing popularity among young adults. Recent literature has documented reports of acute kidney injury in association with the use of synthetic cannabinoids; however, there is no report of TINU syndrome development secondary to using of synthetic cannabinoids...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27436034/rare-allergic-reaction-of-the-kidney-sitagliptin-induced-acute-tubulointerstitial-nephritis
#16
Ali A Alsaad, Sarah M Dhannoon, Sally-Ann L Pantin, Ivan E Porter
A 56-year-old man with a history of diabetes mellitus type-2 and stage-2 chronic kidney disease secondary to diabetic nephropathy presented with an acute deterioration of kidney function. Non-invasive work-up failed to reveal the underlying aetiology for the acute kidney failure. Kidney biopsy revealed acute tubulointerstitial nephritis (ATIN) which was attributed to sitagliptin use. Only few case reports have shown this correlation. Our aim is to alert physicians and other providers of the potential effect of sitagliptin to cause ATIN with this biopsy-proven case...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27418141/bioinformatics-facilitating-the-use-of-microarrays-to-delineate-potential-mirna-biomarkers-in-aristolochic-acid-nephropathy
#17
Yana Lv, Yumei Que, Qiao Su, Qiang Li, Xi Chen, Haitao Lu
Aristolochic acid nephropathy (AAN) is a rapidly progressive acute or chronic tubulointerstitial nephritis (TIN). The present study attempted to explore the molecular mechanisms underlying the miRNA-directed development of AAN. Our differentially expressed analysis identified 11 DE-miRNAs and retrieved the target genes of these DE-miRNAs; then, network analysis and functional analysis further identified 6 DE-miRNAs (has-miR-192, has-miR-194, has-miR-542-3p, has-miR-450a, has-miR-584, has-miR-33a) as phenotypic biomarkers of AAN...
July 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27403615/antineoplastic-treatment-and-renal-injury-an-update-on-renal-pathology-due-to-cytotoxic-and-targeted-therapies
#18
Megan L Troxell, John P Higgins, Neeraja Kambham
Cancer patients experience kidney injury from multiple sources, including the tumor itself, diagnostic procedures, hypovolemia, infection, and drug exposure, superimposed upon baseline chronic damage. This review will focus on cytotoxic or targeted chemotherapy-associated renal injury. In this setting, tubulointerstitial injury and thrombotic microangiopathy (vascular injury) are more common than other forms of kidney injury including glomerular. Cisplatin, pemetrexed, and ifosfamide are well-known causes of acute tubular injury/necrosis...
September 2016: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/27367994/clinicopathologic-characteristics-treatment-and-outcomes-of-tubulointerstitial-nephritis-and-uveitis-syndrome-in-adults-a-national-retrospective-strobe-compliant-study
#19
Mathieu Legendre, Hervé Devilliers, Laurent Perard, Matthieu Groh, Habdelamid Nefti, Bertrand Dussol, Salim Trad, Fatouma Touré, Sébastien Abad, Jean-Jacques Boffa, Luc Frimat, Stéphane Torner, Alexandre Seidowsky, Ziad André Massy, David Saadoun, Virginie Rieu, Yoland Schoindre, Emmanuel Heron, Thierry Frouget, Arnaud Lionet, François Glowacki, Laurent Arnaud, Christiane Mousson, Jean-François Besancenot, Jean-Michel Rebibou, Philip Bielefeld
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, defined by the association of idiopathic acute TINU. The aim of our work was to determine the characteristics of adult TINU syndrome in France, and to assess factors (including treatment) influencing medium-term prognosis.We conducted a nationwide study including 20 French hospitals. Clinical, laboratory, and renal histopathologic data of 41 biopsy-proven TINU syndromes were retrospectively collected. The patients were diagnosed between January 1, 1999 and December 1, 2015...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27282937/clinicopathological-features-of-acute-kidney-injury-associated-with-immune-checkpoint-inhibitors
#20
Frank B Cortazar, Kristen A Marrone, Megan L Troxell, Kenneth M Ralto, Melanie P Hoenig, Julie R Brahmer, Dung T Le, Evan J Lipson, Ilya G Glezerman, Jedd Wolchok, Lynn D Cornell, Paul Feldman, Michael B Stokes, Sarah A Zapata, F Stephen Hodi, Patrick A Ott, Michifumi Yamashita, David E Leaf
Immune checkpoint inhibitors (CPIs), monoclonal antibodies that target inhibitory receptors expressed on T cells, represent an emerging class of immunotherapy used in treating solid organ and hematologic malignancies. We describe the clinical and histologic features of 13 patients with CPI-induced acute kidney injury (AKI) who underwent kidney biopsy. Median time from initiation of a CPI to AKI was 91 (range, 21 to 245) days. Pyuria was present in 8 patients, and the median urine protein to creatinine ratio was 0...
September 2016: Kidney International
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