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https://www.readbyqxmd.com/read/29245065/diclofenac-induced-renal-toxicity-in-female-wistar-albino-rats-is-protected-by-the-pre-treatment-of-aqueous-leaves-extract-of-madhuca-longifolia-through-suppression-of-inflammation-oxidative-stress-and-cytokine-formation
#1
Jerine Peter S, Sabina Evan Prince
CONTEXT: Kidney has a vital role in renal clearance, maintenance of blood pressure, elimination of toxic products and formation of prostaglandins. Certain medications are known to cause renal injury on its frequent usage and high dosage. Diclofenac is a non-steroidal anti-inflammatory drug which is used in the treatment of pain and arthritis. Madhuca longifolia is a deciduous tree which is known to the have anti-microbial, anti-ulcer, hepatoprotective, anti-diabetic, anti-inflammatory and analgesic activity...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29226327/medication-use-and-kidney-cancer-survival-a-population-based-study
#2
Madhur Nayan, David N Juurlink, Peter C Austin, Erin M Macdonald, Antonio Finelli, Girish S Kulkarni, Robert J Hamilton
Several studies demonstrate that use of commonly-prescribed medications is associated with improved survival in various malignancies. Methods of classifying medication use in many of these studies, however, do not account for intermittent or cumulative use. Moreover, there are limited data in kidney cancer. Therefore, we performed a population-based cohort study utilizing healthcare databases in Ontario, Canada. We identified patients aged ≥65 with an incident diagnosis of kidney cancer between 1997-2013 and examined use of nine putative anti-neoplastic medications using prescription claims...
December 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29214511/managing-gout-flares-in-the-elderly-practical-considerations
#3
Abhishek Abhishek
Gout is common in the elderly, affecting an estimated 4.7 million people aged > 60 years in the USA alone. The incidence and prevalence of gout increases, and male predisposition to gout reduces, with increasing age. The elderly have more comorbidities, and gout manifests differently, with more frequent involvement of knees, ankles, and wrists at disease onset, systemic upset, and tophi. Comorbidities and polypharmacy make the management of gout flares challenging in this population. Intra-articular corticosteroid injection remains the treatment of choice for accessible joints, oral prednisolone is preferred over low-dose colchicine, and non-steroidal anti-inflammatory drugs (NSAIDs) are best avoided...
December 6, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29202670/cardiovascular-safety-of-non-steroidal-anti-inflammatory-drugs-revisited
#4
Chris Walker, Luigi M Biasucci
Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used to treat inflammatory pain for decades. More recently, newer NSAIDs were developed to target the inducible isoform of cyclooxygenase (COX), COX-2, with the aim of reducing gastrointestinal toxicity. While the COX-2 selective inhibitors were effective in reducing pain and gastrointestinal harm, they soon were associated with an increased risk of adverse cardiovascular events. Initially, the view emerged that selective inhibition of COX-2, and sparing of COX-1, was responsible for the increased cardiovascular harm observed...
December 5, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29187701/association-between-concomitant-use-of-acyclovir-or-valacyclovir-with-nsaids-and-an-increased-risk-of-acute-kidney-injury-data-mining-of-fda-adverse-event-reporting-system
#5
Zhihua Yue, Jinhai Shi, Haona Li, Huiyi Li
NSAIDs are likely to be used concomitantly with acyclovir or valacyclovir in clinical practice, but the study on the safety of such combinations was seldom reported. The objective of the study was to investigate reports of acute kidney injury(AKI) events associated with the concomitant use of oral acyclovir or valacyclovir with an NSAID by using the United States Food and Drug Administration(FDA) Adverse Event Reporting System (AERS) database between January 2004 and June 2012. The frequency of AKI events in patients while simultaneously taking either acyclovir or valacyclovir and an NSAID was compared using the Chi-square test...
November 28, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29178625/ileus-management-international-imagine-protocol-for-a-multicentre-observational-study-of-ileus-after-colorectal-surgery
#6
(no author information available yet)
AIM: The management of postoperative ileus (POI) following colorectal surgery remains controversial. It is the commonest complication after elective colorectal resection and is associated with an increased incidence of postoperative adverse events. The prevention and management of POI remains unstandardised. This study aims to describe an international profile of gastrointestinal recovery after colorectal surgery and will assess the role of non-steroidal anti-inflammatory drugs (NSAIDs), when used as postoperative analgesia, in expediting the return of gastrointestinal function...
November 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29174580/a-systematic-review-and-meta-analysis-comparing-the-efficacy-of-nonsteroidal-anti-inflammatory-drugs-opioids-and-paracetamol-in-the-treatment-of-acute-renal-colic
#7
REVIEW
Sameer A Pathan, Biswadev Mitra, Peter A Cameron
CONTEXT: Renal colic is a common, acute presentation of urolithiasis that requires immediate pain relief. European Association of Urology guidelines recommend nonsteroidal anti-inflammatory drugs (NSAIDs) as the preferred analgesia. However, the fear of NSAID adverse effects and the uncertainty about superior analgesic effect have maintained the practice of advocating intravenous opioids as the initial analgesia. OBJECTIVE: The objective of this systematic review and meta-analysis was to compare the safety and efficacy of NSAIDs with opioids and paracetamol (acetaminophen) for the management of acute renal colic...
November 21, 2017: European Urology
https://www.readbyqxmd.com/read/29163153/ketogal-a-derivative-ketorolac-molecule-with-minor-ulcerogenic-and-renal-toxicity
#8
Roberto Russo, Carmen De Caro, Bice Avallone, Salvatore Magliocca, Maria Nieddu, Gianpiero Boatto, Roberta Troiano, Rosario Cuomo, Carla Cirillo, Carmen Avagliano, Claudia Cristiano, Giovanna La Rana, Giovanni Sarnelli, Antonio Calignano, Maria G Rimoli
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activity, present on the Italian market since 1991. Despite the excellent therapeutic activity, the chronic use of ketorolac has long been limited owing to the high incidence of gastrointestinal and kidney side events. In our previous study, we demonstrated that ketorolac-galactose conjugate (ketogal), synthesized and tested in a single-dose study, was able to reduce ulcerogenicity, while preserving the high pharmacological efficacy of its parent drug...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29154782/neutrophil-depletion-protects-against-zomepirac-induced-acute-kidney-injury-in-mice
#9
Shohei Yamashita, Shingo Oda, Hideko Endo, Koichi Tsuneyama, Tsuyoshi Yokoi
Acyl glucuronide (AG) metabolites of carboxylic acid-containing drugs have been implicated in drug toxicity. Zomepirac (ZP) is a non-steroidal anti-inflammatory drug that was withdrawn from the market because of anaphylactic reactions and renal injury. We recently established a novel mouse model of ZP-induced kidney injury by increasing zomepirac acyl-glucuronide (ZP-AG) concentration via pretreatment with tri-O-tolyl phosphate, a nonselective esterase inhibitor, and l-buthionine-(S,R)-sulfoximine, a glutathione synthesis inhibitor...
November 14, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29142967/association-of-nonsteroidal-anti-inflammatory-drug-use-with-stroke-among-dialysis-patients
#10
Chih-Cheng Hsu, Yu-Kang Chang, Yueh-Han Hsu, Yu-Ru Lo, Jia-Sin Liu, Chao A Hsiung, Hui-Ju Tsai
Introduction: Limited studies have evaluated risk of stroke associated with the use of NSAIDs in patients with end-stage kidney disease. We examined the adverse effects of selective and nonselective NSAID use on the risk of stroke in dialysis patients. Methods: A case-crossover study was conducted using medical claims data from the National Health Insurance Research Database in Taiwan. We identified patients with ischemic and hemorrhagic stroke (defined as International Classification of Diseases, 9th revision, Clinical Modification codes 433, 434, and 436 for ischemic stroke and 430 and 431 for hemorrhagic stroke) from inpatient claims during the period from 2003 to 2012...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29116624/the-concomitant-use-of-diuretics-non-steroidal-anti-inflammatory-drugs-and-angiotensin-converting-enzyme-inhibitors-or-angiotensin-receptor-blockers-triple-whammy-extreme-heat-and-in-hospital-acute-kidney-injury-in-older-medical-patients
#11
Arduino A Mangoni, Feruza Kholmurodova, Lidia Mayner, Paul Hakendorf, Richard J Woodman
INTRODUCTION: We investigated whether the concomitant use of diuretics, non-steroidal anti-inflammatory drugs, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (triple whammy, TW) predicts in-hospital acute kidney injury (AKI) and whether admission during recorded periods of extreme heat influences this association. METHODS: We retrospectively collected data on patient characteristics and use of TW/non-TW drugs on admission, AKI (increase in serum creatinine ≥ 27 µmol/l either within the first 48 h of admission or throughout hospitalization, primary outcome), length of stay (LOS), and mortality (secondary outcomes) in medical patients ≥65 years admitted (1) during five consecutive heat waves (HWs) between 2007 and 2009 (n = 382) or (2) either before or after each HW, matched for HW period, age, and admission day of the week (non-HW, controls, n = 1339)...
November 7, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29089041/the-increasing-rates-of-acute-interstitial-nephritis-in-australia-a-single-centre-case-series
#12
Gregory J Wilson, Adrian L Kark, Leo P Francis, Wendy Hoy, Helen G Healy, Andrew J Mallett
BACKGROUND: The Australian Institute of Health and Welfare's first report into acute kidney injury demonstrated a significant increase in the incidence of acute-tubulo interstitial nephritis, the ICD-10 code representing both acute interstitial nephritis and pyelonephritis, in women aged less than 55 years. In contrast, recent case series have reported rising rates of drug induced acute interstitial nephritis predominantly among elderly patients. Due to several limitations with the Australian Institute of Health and Welfare report, this new trend requires further investigation to determine if rates of acute interstitial nephritis are truly increasing among younger Australian women...
October 31, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29081218/effects-of-aspirin-nonsteroidal-anti-inflammatory-drugs-statin-and-cox2-inhibitor-on-the-developments-of-urological-malignancies-a-population-based-study-with-10-year-follow-up-data-in-korea
#13
Minyong Kang, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Chang Wook Jeong
Purpose: The purpose of this study was to determine the impact of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), statin and cyclooxygenase 2 (COX-2) inhibitor on the development of kidney, prostate and urothelial cancers by analyzing the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC) database. Materials and Methods: Among a representative sample cohort of 1,025,340 participants in NHIS-NSC database in 2002, we extracted data of 799,850 individuals who visited the hospital more than once, and finally included 321,122 individuals aged 40 and older...
October 27, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29035197/drug-induced-kidney-injury-a-large-case-series-from-the-berlin-case-control-surveillance-study%C3%A2
#14
Antonios Douros, Elisabeth Bronder, Andreas Klimpel, Christiane Erley, Edeltraut Garbe, Reinhold Kreutz
OBJECTIVES: Drug-induced kidney injury (DIKI) may affect patients regardless of their baseline kidney function. Therefore, this study evaluated DIKI in patients with or without previous chronic kidney disease (CKD). MATERIALS AND METHODS: Potential DIKI cases were ascertained using the network of the Berlin Case-Control Surveillance Study in all 51 Berlin hospitals from April 2010 until December 2011. Via face-to-face interviews and medical chart reviews, information on all previous drug intake, comorbidities, and demographics was gathered...
October 16, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29030657/meloxicam-and-risk-of-myocardial-infarction-a-population-based-nested-case-control-study
#15
Deepan Dalal, Maureen Dubreuil, Christine Peloquin, Tuhina Neogi, Yuqing Zhang, Hyon Choi, David Felson
Certain non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with an increased risk of myocardial infarction (MI), a risk linked to cyclo-oxygenase-2 inhibition. There are limited studies assessing the risk of MI associated with meloxicam, an increasingly popular drug with COX-2 inhibiting properties. A nested matched case-control study using The Health Improvement Network, a UK population-based database was conducted. NSAID users between 35 and 89 years of age with at least 1 year enrollment in the cohort were included...
December 2017: Rheumatology International
https://www.readbyqxmd.com/read/29023532/risk-factors-for-gallstones-and-kidney-stones-in-a-cohort-of-patients-with-inflammatory-bowel-diseases
#16
Stefania Fagagnini, Henriette Heinrich, Jean-Benoît Rossel, Luc Biedermann, Pascal Frei, Jonas Zeitz, Marianne Spalinger, Edouard Battegay, Lukas Zimmerli, Stephan R Vavricka, Gerhard Rogler, Michael Scharl, Benjamin Misselwitz
BACKGROUND: Gallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications. OBJECTIVES: Identifying risk factors for gallstones and kidney stones in IBD patients. METHODS: Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of diseases characteristics with gallstones and kidney stones in univariate and multivariate logistic regression analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28989019/drug-disease-interaction-effect-of-inflammation-and-nonsteroidal-anti-inflammatory-drugs-on-cytochrome-p450-metabolites-of-arachidonic-acid
#17
Ali Aghazadeh-Habashi, Waheed Asghar, Fakhreddin Jamali
Inflammatory conditions increase cardiovascular (CV) risk. Some nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to treat pain and inflammation are also associated with CV complications. Inflammation, but not NSAIDs, disrupts the balance of vasodilator and vasoconstrictor components of the renin-angiotensin system within the heart. Herein, we report the effect of both inflammation and NSAIDs (rofecoxib, celecoxib, and meloxicam) on the physiologically active cytochrome P450 metabolites of arachidonic acid (ArA) in the rat with adjuvant arthritis...
October 6, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28975090/chronic-dietary-oxalate-nephropathy-after-intensive-dietary-weight-loss-regimen
#18
Gebran Khneizer, Ahmad Al-Taee, Meher S Mallick, Bahar Bastani
BACKGROUND: Hyperoxaluria has been associated with nephrolithiasis as well as acute and chronic kidney disease. We present a case of end stage renal failure caused by excessive dietary oxalate intake in a dietary weight loss regimen. CASE PRESENTATION: A 51-year-old Caucasian male with the past medical history of type 2 diabetes mellitus, gout, hypertension and morbid obesity was referred to the primary care clinic after being found pale and easily fatigued. The patient had lost 36 kg over a 7-month period by implementing exercise and intense dietary measures that included 6 meals of spinach, kale, berries, and nuts...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28972983/gabapentin-opioids-and-the-risk-of-opioid-related-death-a-population-based-nested-case-control-study
#19
Tara Gomes, David N Juurlink, Tony Antoniou, Muhammad M Mamdani, J Michael Paterson, Wim van den Brink
BACKGROUND: Prescription opioid use is highly associated with risk of opioid-related death, with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first opioid prescription. Although gabapentin is widely perceived as safe, drug-induced respiratory depression has been described when gabapentin is used alone or in combination with other medications. Because gabapentin and opioids are both commonly prescribed for pain, the likelihood of co-prescription is high...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28956324/treatment-with-allopurinol-is-associated-with-lower-risk-of-acute-kidney-injury-in-patients-with-gout-a-retrospective-analysis-of-a-nested-cohort
#20
Fernando Perez-Ruiz
INTRODUCTION: Gout is characterized by recurrent episodes of acute inflammation of joint structures, called gout flares, and flares are commonly treated with nonsteroidal anti-inflammatory drugs (NSAIDs). The objective of the study was to evaluate risk factors associated with acute kidney injury (AKI) attributed to NSAIDs in a cohort of patients who were exposed to NSAIDs to treat gout flares prior to urate-lowering therapy. METHODS: Retrospective analysis of a nested cohort of 983 gout patients in whom general variables (age, gender, renal function, ethanol intake, hypertension, hyperlipidemia, diabetes, vascular events, diuretic use) and also variables related to gout and severity of gout (serum urate levels, number for flares per year, presence of tophi, joint distribution, X-ray involvement, previous urate-lowering therapy) were available for analysis...
December 2017: Rheumatology and Therapy
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