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https://www.readbyqxmd.com/read/29686921/axial-spondyloarthritis-and-autosomal-dominant-polycystic-kidney-disease-in-two-siblings-a-rare-cooccurrence
#1
Ozan Volkan Yurdakul, Abdulkerim Furkan Tamer, Okan Küçükakkaş, Aylin Rezvani
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequently occurring hereditary kidney disease, and axial spondyloarthritis (SpA) is one of the most frequently occurring rheumatic diseases. Treatment-related decisions for axial SpA may pose a challenge in case of renal involvement. The authors describe two siblings with cooccurrence of these two diseases. The association of these two diseases is not well known. Practitioners should monitor renal function in SpA patients and take treatment-related decisions regarding renal involvement...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29564981/synthesis-cyclooxygenase-2-inhibition-anti-inflammatory-evaluation-and-docking-study-of-substituted-n-3-4-5-trimethoxyphenyl-benzo-d-oxazole-derivatives
#2
Avneet Kaur, Sharad Wakode, Dharam Pal Pathak, Vidushi Sharma, Ashok K Shakya
BACKGROUND: Non-steroidal anti-inflammatory drugs are widely used for many years, but the chronic use of NSAID's leads to gastric side effects, ulceration and kidney problems. These side effects are due to non-selective inhibition of COX-2 along with COX-1. Therefore, it is imperative to develop novel and selective COX-2 inhibitors Objective: In this paper wehave synthesized a series of novel hybrids comprising of substituted-N-(3,4,5-trimethoxyphenyl)-benzo[d]oxazole derivatives and screened for the treatment of inflammation...
March 21, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29563839/acetaminophen-administration-and-the-risk-of-acute-kidney-injury-a-self-controlled-case-series-study
#3
Shusuke Hiragi, Hiroyuki Yamada, Tatsuo Tsukamoto, Kazuki Yoshida, Naoya Kondo, Takeshi Matsubara, Motoko Yanagita, Hiroshi Tamura, Tomohiro Kuroda
Background: Acetaminophen (APAP) is frequently used for analgesia and is considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for the kidneys. However, there is little epidemiological evidence of the association between APAP and acute kidney injury (AKI). Objectives: To examine the association between APAP and AKI using the self-controlled case series (SCCS) method, which is a novel strategy to control between-person confounders by comparing the risk and reference periods in each patient...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29562792/paracetamol-treatment-for-patent-ductus-arteriosus-practice-and-attitudes-in-australia-and-new-zealand
#4
L A Dowd, B J Wheeler, H S Al-Sallami, R S Broadbent, L K Edmonds, N J Medlicott
AIM: To describe the current clinical practices and attitudes of neonatologists towards paracetamol treatment of PDA in Australia (AU) and New Zealand (NZ). METHOD: A web-based survey of all neonatologists registered under the 2017 Australia New Zealand Neonatal Network (ANZNN) was conducted. RESULTS: The response rate for the survey was 67%, (141/210). Of those respondents, 37% stated their unit had a written policy outlining how to treat patent ductus arteriosus (PDA)...
April 3, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29553279/trends-in-opioid-and-nonsteroidal-anti-inflammatory-use-and-adverse-events
#5
Veronica Fassio, Sherrie L Aspinall, Xinhua Zhao, Donald R Miller, Jasvinder A Singh, Chester B Good, Francesca E Cunningham
OBJECTIVES: To describe the prevalence and incidence of opioid and nonsteroidal anti-inflammatory drug (NSAID) use before and since the start of the Veterans Health Administration (VHA) Opioid Safety Initiative (OSI) and to assess rates of adverse events (AEs). STUDY DESIGN: Historical cohort study. METHODS: The OSI began in August 2012 and was fully implemented by the end of fiscal year (FY) 2013. The study timeframe was categorized into baseline (FY 2011-2012), transition (FY 2013), and postimplementation (FY 2014-2015) phases...
March 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29547895/gout-state-of-the-art-after-a-decade-of-developments
#6
Tristan Pascart, Frédéric Lioté
This review article summarizes the relevant English literature on gout from 2010 through April 2017. It emphasizes that the current epidemiology of gout indicates a rising prevalence worldwide, not only in Western countries but also in Southeast Asia, in close relationship with the obesity and metabolic syndrome epidemics. New pathogenic mechanisms of chronic hyperuricaemia focus on the gut (microbiota, ABCG2 expression) after the kidney. Cardiovascular and renal comorbidities are the key points to consider in terms of management...
March 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29529172/prescription-of-high-risk-medications-among-patients-with-chronic-kidney-disease-a-cross-sectional-study-from-the-washington-wyoming-alaska-montana-and-idaho-region-practice-and-research-network
#7
Janelle Guirguis-Blake, Gina A Keppel, John Holmes, Rex W Force, William Kriegsman, Laura-Mae Baldwin
Background: Patients with chronic kidney disease (CKD) are at high risk for adverse drug events related to medication dosing errors and prescriptions for relatively contraindicated medications, such as non-steroidal anti-inflammatory drugs (NSAIDs). Objectives: To examine the scope of and variation in prescribing relatively contraindicated medications and medications above the recommended dose levels among patients with stage III/IV CKD in primary care practice...
February 26, 2018: Family Practice
https://www.readbyqxmd.com/read/29521084/novel-engineered-microgels-with-amphipathic-network-structures-for-simultaneous-tumor-and-inflammation-depression
#8
Xianjing Zhou, Yanxin Qi, Zhijun Zhang, Jingjing Nie, Yubin Huang, Bin-Yang Du
A novel engineered microgels with amphipathic network structures were designed and synthesized by copolymerizing N-isopropylacrylamide (NIPAm), 1-vinylimidazole (VIM) and 2-(cinnamoyloxy) ethyl methacrylate (CEMA) in the presence of 1, 6-dibromohexane. The engineered microgels possess hydrophilic quaternization crosslinking structures and hydrophobic crosslinking inner nanodomains, which are suitable for loading and simultaneous release of hydrophilic non-steroidal anti-inflammatory drug (NSAID), diclofenac sodium (DS), and hydrophobic antic cancer drug, doxorubicin (DOX), respectively...
March 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29497028/nonsteroidal-anti-inflammatory-drugs-and-analgesics-use-by-kidney-transplant-recipients
#9
Maria Mulka-Gierek, Bartosz Foroncewicz, Leszek Pączek, Elżbieta Wawiórko, Joanna Kamińska, Maciej Kosieradzki, Piotr Małkowski, Bianka Małczuk, Sławomir Nazarewski, Krzysztof Mucha
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics are the most commonly used drugs and are increasingly available over-the-counter (OTC). In certain groups of patients, including kidney transplant recipients, their use may be complicated by adverse effects or drug interactions. The aim of our study was to assess the causes and frequency of OTC NSAIDs or analgesics use, as well as the awareness of related side effects. MATERIAL AND METHODS We enrolled 94 randomly selected kidney transplant recipients, who represented 5% of all kidney transplant recipients at our center...
March 2, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29467030/drug-discontinuation-before-contrast-procedures-and-the-effect-on-acute-kidney-injury-and-other-clinical-outcomes-a-systematic-review-protocol
#10
Swapnil Hiremath, Jeanne Françoise Kayibanda, Benjamin J W Chow, Dean Fergusson, Greg A Knoll, Wael Shabana, Brianna Lahey, Olivia McBride, Alexandra Davis, Ayub Akbari
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is defined as worsening of renal function after the administration of iodinated contrast material. In patients with cardiovascular disease, kidney disease, and/or diabetes, renin-angiotensin system blockers, non-steroidal anti-inflammatory drugs, diuretics, and metformin can increase the risk of CI-AKI when undergoing contrast imaging. Despite CI-AKI being the leading iatrogenic cause of acute kidney injury, there is a lack of sufficient scientific evidence supporting which drugs should be stopped, when they should be stopped, and when they should be resumed...
February 21, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29461420/the-effect-of-ibuprofen-on-muscle-hematological-and-renal-function-hydric-balance-pain-and-performance-during-intense-long-distance-running
#11
Raphael Fabricio de Souza, Dihogo Gama de Matos, Alexandre Reis Pires Ferreira, Philip Chilibeck, Natalie de Almeida Barros, Alan Santos de Oliveira, Luana Mendonça Cercato, Danielle Soares da Silva, Felipe José Aidar
The aim of this study was to investigate the effect of prophylactic use of nonsteroidal anti-inflammatory drugs (NSAID, i.e. Ibuprofen) on physical performance, vertical jump, muscle biomarkers, liver, kidney, acute pain and hydration status of participants in the 42 km Trail Running Challenge, a long-distance race integrated over mountain routes. The sample consisted of 20 males randomly divided into two groups: a control group (CG) and an experimental group (EG) with 12 completing the race (41.1±8.8 y; 75...
February 14, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29460083/kidney-function-and-use-of-nonsteroidal-anti-inflammatory-drugs-among-elderly-people-a-cross-sectional-study-on-potential-hazards-for-an-at-risk-population
#12
Sara Modig, Sölve Elmståhl
Background Renal elimination normally decreases with age. Nonsteroidal antiinflammatory drugs (NSAIDs) carry a risk of additional kidney damage. Objective The aims of this study were to assess the prevalence of NSAIDs in the elderly (aged ≥ 65) population in Sweden, explore reasons for any possible differences in the level of use and assess their kidney functions. Setting Data were obtained from the cohort study Good Aging in Skåne, Sweden. Patients aged 65 or more were included. Methods Medication lists were collected as well as variables such as cognition and education levels...
February 19, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29382434/diclofenac-acetaminophen-combination-induced-acute-kidney-injury-in-postoperative-pain-relief
#13
Yan Zhu, Ping Xu, Qing Wang, Jian-Quan Luo, Yi-Wen Xiao, Yi-Yi Li, Yan-Gang Zhou, Andrew Cave, Hoan Linh Banh
PURPOSE: The objective of this study was to determine: 1) the incidence and the risk factors of diclofenac/acetaminophen combination as a single agent induced Acute Kidney Injury (AKI) in postoperative pain relief 2) the average cost and length of hospital stay for patients in AKI group and non-AKI group. METHODS: All patients with no prior history of chronic kidney disease (CKD) and normal serum creatinine [44~130 μmol /l] who received diclofenac and acetaminophen combination as a single agent intramuscularly (IM) between January and December 2015 in The Second Xiangya Hospital, Changsha, Hunan, China were included in this retrospective own-control study...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29284721/migraine-and-subsequent-chronic-kidney-disease-risk-a-nationwide-population-based-cohort-study
#14
Shuo-Chun Weng, Chia-Lin Wu, Chew-Teng Kor, Ping-Fang Chiu, Ming-Ju Wu, Chia-Chu Chang, Der-Cherng Tarng
OBJECTIVE: We compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine and matched controls without migraine in this large-scale retrospective cohort study. DESIGN: Population-based cohort study. SETTING: 8880 subjects with migraine and 503 070 subjects without migraine were enrolled between January 1, 2000 and December 31, 2013, all diagnosed to be without kidney disease. All the participants were registered in the National Health Insurance Research Database...
December 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/29245065/diclofenac-induced-renal-toxicity-in-female-wistar-albino-rats-is-protected-by-the-pre-treatment-of-aqueous-leaves-extract-of-madhuca-longifolia-through-suppression-of-inflammation-oxidative-stress-and-cytokine-formation
#15
Jerine Peter S, Sabina Evan Prince
CONTEXT: Kidney has a vital role in renal clearance, maintenance of blood pressure, elimination of toxic products and formation of prostaglandins. Certain medications are known to cause renal injury on its frequent usage and high dosage. Diclofenac is a non-steroidal anti-inflammatory drug which is used in the treatment of pain and arthritis. Madhuca longifolia is a deciduous tree which is known to the have anti-microbial, anti-ulcer, hepatoprotective, anti-diabetic, anti-inflammatory and analgesic activity...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29226327/medication-use-and-kidney-cancer-survival-a-population-based-study
#16
Madhur Nayan, David N Juurlink, Peter C Austin, Erin M Macdonald, Antonio Finelli, Girish S Kulkarni, Robert J Hamilton
Several studies demonstrate that use of commonly prescribed medications is associated with improved survival in various malignancies. Methods of classifying medication use in many of these studies, however, do not account for intermittent or cumulative use. Moreover, there are limited data in kidney cancer. Therefore, we performed a population-based cohort study utilizing healthcare databases in Ontario, Canada. We identified patients aged ≥65 with an incident diagnosis of kidney cancer between 1997 and 2013 and examined use of nine putative anti-neoplastic medications using prescription claims...
May 1, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29214511/managing-gout-flares-in-the-elderly-practical-considerations
#17
Abhishek Abhishek
Gout is common in the elderly, affecting an estimated 4.7 million people aged > 60 years in the USA alone. The incidence and prevalence of gout increases, and male predisposition to gout reduces, with increasing age. The elderly have more comorbidities, and gout manifests differently, with more frequent involvement of knees, ankles, and wrists at disease onset, systemic upset, and tophi. Comorbidities and polypharmacy make the management of gout flares challenging in this population. Intra-articular corticosteroid injection remains the treatment of choice for accessible joints, oral prednisolone is preferred over low-dose colchicine, and non-steroidal anti-inflammatory drugs (NSAIDs) are best avoided...
December 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29202670/cardiovascular-safety-of-non-steroidal-anti-inflammatory-drugs-revisited
#18
REVIEW
Chris Walker, Luigi M Biasucci
Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used to treat inflammatory pain for decades. More recently, newer NSAIDs were developed to target the inducible isoform of cyclooxygenase (COX), COX-2, with the aim of reducing gastrointestinal toxicity. While the COX-2 selective inhibitors were effective in reducing pain and gastrointestinal harm, they soon were associated with an increased risk of adverse cardiovascular events. Initially, the view emerged that selective inhibition of COX-2, and sparing of COX-1, was responsible for the increased cardiovascular harm observed...
January 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29187701/association-between-concomitant-use-of-acyclovir-or-valacyclovir-with-nsaids-and-an-increased-risk-of-acute-kidney-injury-data-mining-of-fda-adverse-event-reporting-system
#19
Zhihua Yue, Jinhai Shi, Haona Li, Huiyi Li
Nonsteroidal anti-inflammatory drugs (NSAIDs) are likely to be used concomitantly with acyclovir or valacyclovir in clinical practice, but the study on the safety of such combinations was seldom reported. The objective of the study was to investigate reports of acute kidney injury (AKI) events associated with the concomitant use of oral acyclovir or valacyclovir with an NSAID by using the United States Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database between January 2004 and June 2012...
February 1, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29178625/ileus-management-international-imagine-protocol-for-a-multicentre-observational-study-of-ileus-after-colorectal-surgery
#20
S J Chapman
AIM: The management of postoperative ileus following colorectal surgery remains controversial. It is the commonest complication after elective colorectal resection and is associated with an increased incidence of postoperative adverse events. The prevention and management of postoperative ileus remains unstandardized. This study aims to describe an international profile of gastrointestinal recovery after colorectal surgery and will assess the role of non-steroidal anti-inflammatory drugs, when used as postoperative analgesia, in expediting the return of gastrointestinal function...
January 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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