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https://www.readbyqxmd.com/read/29679848/a-deep-boltzmann-machine-driven-level-set-method-for-heart-motion-tracking-using-cine-mri-images
#1
Jian Wu, Thomas R Mazur, Su Ruan, Chunfeng Lian, Nalini Daniel, Hilary Lashmett, Laura Ochoa, Imran Zoberi, Mark A Anastasio, H Michael Gach, Sasa Mutic, Maria Thomas, Hua Li
Heart motion tracking for radiation therapy treatment planning can result in effective motion management strategies to minimize radiation-induced cardiotoxicity. However, automatic heart motion tracking is challenging due to factors that include the complex spatial relationship between the heart and its neighboring structures, dynamic changes in heart shape, and limited image contrast, resolution, and volume coverage. In this study, we developed and evaluated a deep generative shape model-driven level set method to address these challenges...
April 6, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29679719/localization-of-cholecystokinin-in-the-zebrafish-retina-from-larval-to-adult-stage
#2
M C Guerrera, F Abbate, G Di Caro, G P Germanà, M Levanti, V Micale, G Montalbano, R Laurà, A Germanà, U Muglia
The peptide hormone cholecistokinin (CCK) plays a key role in the central and peripheral nervous system. It is known to be involved in the digestive physiology and in the regulation of food intake. Moreover, the CCK expression has also been detected in the retina of different vertebrates, including fish, although its biological activity in this tissue remains to be elucidated. In literature no data are yet available about the CCK-immunoreactivity in the zebrafish retina during development. Therefore, the aim of the study was to investigate the distribution of sulfated cholecystokinin octapeptide (CCK8-S) as a well preserved form during evolution in the zebrafish retina from 3days post hatching (dph) until adult stage, using immunohistochemistry in order to elucidate the potential role of this protein in the development and maintenance of normal retinal homeostasis...
April 18, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29678724/thyroid-hormone-actions-on-male-reproductive-system-of-teleost-fish
#3
REVIEW
Aldo Tovo-Neto, Maira da Silva Rodrigues, Hamid R Habibi, Rafael Henrique Nóbrega
Thyroid hormones (THs) play important roles in the regulation of many biological processes of vertebrates, such as growth, metabolism, morphogenesis and reproduction. An increasing number of studies have been focused on the involvement of THs in the male reproductive system of vertebrates, in particular of fish. Therefore, this mini-review aims to summarize the main findings on THs role in male reproductive system of fish, focusing on sex differentiation, testicular development and spermatogenesis. The existing data in the literature have demonstrated that THs exert their roles at the different levels of the hypothalamic-pituitary-gonadal (HPG) axis...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29678686/trends-in-vena-cava-filter-insertions-and-prophylactic-use
#4
John R Power, Kenneth R Nakazawa, Ageliki G Vouyouka, Peter L Faries, Natalia N Egorova
BACKGROUND: Prophylactic vena cava filter (VCF) use in patients without venous thromboembolism is common practice despite ongoing controversy. Thorough analysis of the evolution of this practice is lacking. We describe trends in VCF use and identify events associated with changes in practice. METHODS: Using the National Inpatient Sample, we conducted a retrospective observational study of U.S. adult hospitalizations from 2000 to 2014. Trends in prophylactic VCF insertion were analyzed both across the entire study population and within subgroups according to trauma status and type of concurrent surgery...
April 17, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29678149/comparative-mitochondrial-genomics-of-cryptophyte-algae-gene-shuffling-and-dynamic-mobile-genetic-elements
#5
Jong Im Kim, Hwan Su Yoon, Gangman Yi, Woongghi Shin, John M Archibald
BACKGROUND: Cryptophytes are an ecologically important group of algae comprised of phototrophic, heterotrophic and osmotrophic species. This lineage is of great interest to evolutionary biologists because their plastids are of red algal secondary endosymbiotic origin. Cryptophytes have a clear phylogenetic affinity to heterotrophic eukaryotes and possess four genomes: host-derived nuclear and mitochondrial genomes, and plastid and nucleomorph genomes of endosymbiotic origin. RESULTS: To gain insight into cryptophyte mitochondrial genome evolution, we sequenced the mitochondrial DNAs of five species and performed a comparative analysis of seven genomes from the following cryptophyte genera: Chroomonas, Cryptomonas, Hemiselmis, Proteomonas, Rhodomonas, Storeatula and Teleaulax...
April 20, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29677922/implementing-an-antibiotic-stewardship-information-system-to-improve-hospital-infection-control-a-co-design-process
#6
Mélanie R Maia, Alexandra Simões, Luís V Lapão
HAITooL information system design and implementation was based on Design Science Research Methodology, ensuring full participation, in close collaboration, of researchers and a multidisciplinary team of healthcare professionals. HAITooL enables effective monitoring of antibiotic resistance, antibiotic use and provides an antibiotic prescription decision-supporting system by clinicians, strengthening the patient safety procedures. The design, development and implementation process reveals benefits in organizational and behavior change with significant success...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677685/on-the-phylogenetic-position-of-the-genus-raphidocystis-haptista-centroplasthelida-with-notes-on-the-dimorphism-in-centrohelid-life-cycle
#7
Vasily V Zlatogursky, Daria Drachko, Vladimir I Klimov, Yegor Shishkin
Centrohelid heliozoan Raphidocystis glabra was reisolated for the first time after initial description and put into a clonal culture. Its correct identification was confirmed by scanning and transmission electron microscopy of scales. The first light microscopy data from the living cells were obtained. Phylogenetic analysis of its position using 18S rDNA sequences was also performed. This species branches inside of the Polyplacocystis clade, being closely related to the strain HLO4. The latter was isolated from the same sample with R...
April 5, 2018: European Journal of Protistology
https://www.readbyqxmd.com/read/29677183/divergent-genome-evolution-caused-by-regional-variation-in-dna-gain-and-loss-between-human-and-mouse
#8
Reuben M Buckley, R Daniel Kortschak, David L Adelson
The forces driving the accumulation and removal of non-coding DNA and ultimately the evolution of genome size in complex organisms are intimately linked to genome structure and organisation. Our analysis provides a novel method for capturing the regional variation of lineage-specific DNA gain and loss events in their respective genomic contexts. To further understand this connection we used comparative genomics to identify genome-wide individual DNA gain and loss events in the human and mouse genomes. Focusing on the distribution of DNA gains and losses, relationships to important structural features and potential impact on biological processes, we found that in autosomes, DNA gains and losses both followed separate lineage-specific accumulation patterns...
April 20, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29677104/morphological-evolution-of-vertically-standing-molybdenum-disulfide-nanosheets-by-chemical-vapor-deposition
#9
Song Zhang, Jiajia Liu, Karla Hernandez Ruiz, Rong Tu, Meijun Yang, Qizhong Li, Ji Shi, Haiwen Li, Lianmeng Zhang, Takashi Goto
In this study, we demonstrated the chemical vapor deposition (CVD) of vertically standing molybdenum disulfide (MoS₂) nanosheets, with an unconventional combination of molybdenum hexacarbonyl (Mo(CO)₆) and 1,2-ethanedithiol (C₂H₆S₂) as the novel kind of Mo and S precursors respectively. The effect of the distance between the precursor’s outlet and substrates (denoted as d ) on the growth characteristics of MoS₂, including surface morphology and nanosheet structure, was investigated. Meanwhile, the relationship between the structure characteristics of MoS₂ nanosheets and their catalytic performance for hydrogen evolution reaction (HER) was elucidated...
April 20, 2018: Materials
https://www.readbyqxmd.com/read/29675614/short-term-outcomes-of-sleeve-gastrectomy-conversion-to-r-y-gastric-bypass-multi-center-retrospective-study
#10
Cristian Eugeniu Boru, Francesco Greco, Piero Giustacchini, Marco Raffaelli, Gianfranco Silecchia
INTRODUCTION: The outcomes of failed laparoscopic sleeve gastrectomies (LSG) converted to laparoscopic standard R-Y gastric bypass (LRYGB) in case of insufficient weight loss (IWL), weight regain (WR), and/or severe gastro-esophageal reflux disease (GERD) are scanty. PURPOSE: To evaluate incidence, indications, and short-term outcomes of LSG conversion to LRYGB in three bariatric centers. METHODS: Patients operated between January 2012 and December 2016 by primary LSG, with mean follow-up of 24 months and converted to LRYGB for IWL, WR, and/or GERD, were retrospectively analyzed for demographics, operative details, perioperative complications, comorbidities evolution, and further WL...
April 20, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29675381/anterior-and-posterior-capsule-densitometry-levels-after-femtosecond-laser-assisted-cataract-surgery
#11
Txomin Alberdi, Javier Mendicute, Lucía Bascarán, Olatz Barandika, Javier Ruiz-Ederra
AIM: To analyze and compare five different variables over one year follow-up (1wk, 1, 3, 6 and 12mo): anterior capsule (AC), and posterior capsule (PC) area densitometry values, AC and PC linear densitometry values, and AC opening area reduction ratio after femtosecond laser-assisted cataract surgery. METHODS: This was a prospective comparative study. Seventy-one patients underwent femtosecond laser-assisted cataract surgery on single eye between June 2014 and December 2015...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675356/-in-vivo-fluorescence-imaging-of-hepatocellular-carcinoma-using-a-novel-gpc3-specific-aptamer-probe
#12
Menglong Zhao, Lili Dong, Zhuang Liu, Shuohui Yang, Weizhong Wu, Jiang Lin
Background: Glypican-3 (GPC3) is highly expressed in most of the hepatocellular carcinomas (HCCs), even in small HCCs. It may be used as a potential biomarker for early detection of HCC. The aptamer is a promising targeting agent with unique advantages over antibody. This study was to introduce a novel GPC3 specific aptamer (AP613-1), to verify its specific binding property in vitro , and to evaluate its targeting efficiency in vivo by performing near-infrared (NIR) fluorescence imaging on an HCC xenograft model...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29675170/femtosecond-stimulated-raman-evidence-for-charge-transfer-character-in-pentacene-singlet-fission
#13
Stephanie M Hart, W Ruchira Silva, Renee R Frontiera
Singlet fission is a spin-allowed process in which an excited singlet state evolves into two triplet states. We use femtosecond stimulated Raman spectroscopy, an ultrafast vibrational technique, to follow the molecular structural evolution during singlet fission in order to determine the mechanism of this process. In crystalline pentacene, we observe the formation of an intermediate characterized by pairs of excited state peaks that are red- and blue-shifted relative to the ground state features. We hypothesize that these features arise from the formation of cationic and anionic species due to partial transfer of electron density from one pentacene molecule to a neighboring molecule...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674994/a-cross-sectional-study-on-cerebral-hemodynamics-after-mild-traumatic-brain-injury-in-a-pediatric-population
#14
Corey M Thibeault, Samuel Thorpe, Michael J O'Brien, Nicolas Canac, Mina Ranjbaran, Ilyas Patanam, Artin Sarraf, James LeVangie, Fabien Scalzo, Seth J Wilk, Ramon Diaz-Arrastia, Robert B Hamilton
The microvasculature is prominently affected by traumatic brain injury (TBI), including mild TBI (concussion). Assessment of cerebral hemodynamics shows promise as biomarkers of TBI, and may help inform development of therapies aimed at promoting neurologic recovery. The objective of this study was to assess the evolution in cerebral hemodynamics observable with transcranial Doppler (TCD) ultrasound in subjects suffering from a concussion at different intervals during recovery. Pediatric subjects between the ages of 14 and 19 years clinically diagnosed with a concussion were observed at different points post-injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29674745/publisher-correction-the-sea-lamprey-germline-genome-provides-insights-into-programmed-genome-rearrangement-and-vertebrate-evolution
#15
Jeramiah J Smith, Nataliya Timoshevskaya, Chengxi Ye, Carson Holt, Melissa C Keinath, Hugo J Parker, Malcolm E Cook, Jon E Hess, Shawn R Narum, Francesco Lamanna, Henrik Kaessmann, Vladimir A Timoshevskiy, Courtney K M Waterbury, Cody Saraceno, Leanne M Wiedemann, Sofia M C Robb, Carl Baker, Evan E Eichler, Dorit Hockman, Tatjana Sauka-Spengler, Mark Yandell, Robb Krumlauf, Greg Elgar, Chris T Amemiya
In the version of this article initially published, the present addresses for authors Dorit Hockman and Chris Amemiya were switched. The error has been corrected in the HTML and PDF versions of the article.
April 19, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29674453/multiple-large-scale-gene-and-genome-duplications-during-the-evolution-of-hexapods
#16
Zheng Li, George P Tiley, Sally R Galuska, Chris R Reardon, Thomas I Kidder, Rebecca J Rundell, Michael S Barker
Polyploidy or whole genome duplication (WGD) is a major contributor to genome evolution and diversity. Although polyploidy is recognized as an important component of plant evolution, it is generally considered to play a relatively minor role in animal evolution. Ancient polyploidy is found in the ancestry of some animals, especially fishes, but there is little evidence for ancient WGDs in other metazoan lineages. Here we use recently published transcriptomes and genomes from more than 150 species across the insect phylogeny to investigate whether ancient WGDs occurred during the evolution of Hexapoda, the most diverse clade of animals...
April 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29673330/modular-assembly-of-transposable-element-arrays-by-microsatellite-targeting-in-the-guayule-and-rice-genomes
#17
José A Valdes Franco, Yi Wang, Naxin Huo, Grisel Ponciano, Howard A Colvin, Colleen M McMahan, Yong Q Gu, William R Belknap
BACKGROUND: Guayule (Parthenium argentatum A. Gray) is a rubber-producing desert shrub native to Mexico and the United States. Guayule represents an alternative to Hevea brasiliensis as a source for commercial natural rubber. The efficient application of modern molecular/genetic tools to guayule improvement requires characterization of its genome. RESULTS: The 1.6 Gb guayule genome was sequenced, assembled and annotated. The final 1.5 Gb assembly, while fragmented (N50  = 22 kb), maps > 95% of the shotgun reads and is essentially complete...
April 19, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29672525/comparative-genomic-and-transcriptomic-analysis-of-selected-fatty-acid-biosynthesis-genes-and-cnl-disease-resistance-genes-in-oil-palm
#18
Rozana Rosli, Nadzirah Amiruddin, Mohd Amin Ab Halim, Pek-Lan Chan, Kuang-Lim Chan, Norazah Azizi, Priscilla E Morris, Eng-Ti Leslie Low, Meilina Ong-Abdullah, Ravigadevi Sambanthamurthi, Rajinder Singh, Denis J Murphy
Comparative genomics and transcriptomic analyses were performed on two agronomically important groups of genes from oil palm versus other major crop species and the model organism, Arabidopsis thaliana. The first analysis was of two gene families with key roles in regulation of oil quality and in particular the accumulation of oleic acid, namely stearoyl ACP desaturases (SAD) and acyl-acyl carrier protein (ACP) thioesterases (FAT). In both cases, these were found to be large gene families with complex expression profiles across a wide range of tissue types and developmental stages...
2018: PloS One
https://www.readbyqxmd.com/read/29671703/my-40-year-perspective-on-hand-surgery
#19
Steven E R Hovius
The author presents his transition of his preferred methods for managing acute trauma and degenerative and congenital conditions of the hand. Based on his career-long experience, he discusses conceptual evolution and current status of treatment of Dupuytren's disease and several congenital anomalies of the hand.
May 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29670448/synopsis-of-the-cyclocephaline-scarab-beetles-coleoptera-scarabaeidae-dynastinae
#20
REVIEW
Matthew R Moore, Ronald D Cave, Marc A Branham
The cyclocephaline scarabs (Scarabaeidae: Dynastinae: Cyclocephalini) are a speciose tribe of beetles that include species that are ecologically and economically important as pollinators and pests of agriculture and turf. We provide an overview and synopsis of the 14 genera of Cyclocephalini that includes information on: 1) the taxonomic and nomenclatural history of the group; 2) diagnosis and identification of immature life-stages; 3) economic importance in agroecosystems; 4) natural enemies of these beetles; 5) use as food by humans; 6) the importance of adults as pollination mutualists; 7) fossil cyclocephalines and the evolution of the group; 8) generic-level identification of adults...
2018: ZooKeys
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