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https://www.readbyqxmd.com/read/29221741/balloon-expandable-transaortic-transcatheter-aortic-valve-implantation-with-or-without-predilation
#1
Nikolaos Bonaros, Markus Kofler, Derk Frank, Riccardo Cocchieri, Dariusz Jagielak, Marco Aiello, Joel Lapeze, Mika Laine, Sidney Chocron, Douglas Muir, Walter Eichinger, Matthias Thielmann, Louis Labrousse, Vinayak Bapat, Kjell Arne Rein, Jean-Philippe Verhoye, Gino Gerosa, Hardy Baumbach, Cornelia Deutsch, Peter Bramlage, Martin Thoenes, Mauro Romano
OBJECTIVE: It has been reported that balloon aortic valvuloplasty immediately before transfemoral or transapical transcatheter aortic valve implantation has mostly little to no clinical value. We aimed to provide data on the need for balloon aortic valvuloplasty in patients undergoing transaortic transcatheter aortic valve implantation. METHODS: Patients undergoing transaortic transcatheter aortic valve implantation with the Edwards SAPIEN XT (Nyon, Switzerland) or 3 transcatheter heart valve were prospectively included at 18 sites across Europe...
November 2, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221668/sumoylation-of-smad-4-ameliorates-the-oxidative-stress-induced-apoptosis-in-osteoblasts
#2
Dianhui Xiu, Zongqiang Wang, Lu Cui, Jinlan Jiang, Haishan Yang, Guifeng Liu
Oxidative stress-induced mitochondrial function and cell apoptosis to osteoblasts, plays a critical role in the pathophysiology of osteoporosis. However, mechanisms underlying such process remain not yet clear. We aims in this study to investigate a possible role of SMAD (the mothers against decapentaplegic homolog 4 (SMAD4) in the oxidative stress-induced apoptosis, in homo sapiens osteoblast hFOB1.19 cells. Results demonstrated that the treatment with more than 100μM H2O2 significantly downregulated the cellular viability, whereas markedly induced apoptosis in hFOB1...
December 5, 2017: Cytokine
https://www.readbyqxmd.com/read/29205396/imaging-based-predictors-of-permanent-pacemaker-implantation-after-transcatheter-aortic-valve-replacement
#3
Jared M Routh, Lee Joseph, Brodie R Marthaler, Prashant D Bhave
BACKGROUND: Cardiac conduction abnormalities requiring PPM implantation are major complications of TAVR. We aimed to investigate whether the relationship between prosthetic valve size and cardiac-gated computed tomography (CT) based aortic root complex measurements can aid in recognizing patients at risk for permanent pacemaker (PPM) implantation post-transcatheter aortic valve replacement (TAVR). METHODS: We included 83 of 114 consecutive patients who underwent TAVR with the Edwards Sapien valve at our institution...
December 5, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29203295/deployment-of-a-sapien-3-transcatheter-valve-for-severe-tricuspid-insufficiency-in-a-patient-with-non-obstructive-cor-triatriatum-dexter
#4
Jeremy M Bennett, Irida Nikolla, Antonio Hernandez
No abstract text is available yet for this article.
May 17, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29195844/leaflet-thrombosis-following-transcatheter-aortic-valve-implantation
#5
M Marwan, N Mekkhala, M Göller, J Röther, D Bittner, A Schuhbaeck, M Hell, G Muschiol, J Kolwelter, R Feyrer, C Schlundt, S Achenbach, M Arnold
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is increasingly being offered to high-risk patients with symptomatic aortic valve stenosis. Recent reports have suggested a high incidence of subclinical leaflet thrombosis following bioprosthestic aortic valve replacement. We report the frequency and clinical presentation of leaflet thrombosis identified by cardiac CT in patients referred for follow-up contrast enhanced CT angiography following TAVI. METHODS: 91 consecutive patients referred for follow-up contrast-enhanced CT angiography following TAVI were screened for inclusion in this analysis...
November 9, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29193386/on-structure-and-reaction-mechanism-of-human-acireductone-dioxygenase
#6
Anna Maria Miłaczewska, Ewa Kot, José A Amaya, Thomas M Makris, Marcin Zając, Józef Korecki, Aleksandr Chumakov, Bartosz Trzewik, Sylwia Kędracka-Krok, Władek Minor, Maksymilian Chruszcz, Tomasz Maciej Borowski
Acireductone dioxygenase (ARD) is an intriguing enzyme from the methionine salvage pathway capable of catalyzing two different oxidation reactions with the same substrate, depending on the type of the metal ion in the active site. To date, the structural information regarding ARD-acireductone complex is limited and the reaction mechanisms are still under debate. In this contribution we report results of joint experimental and computational studies undertaken to advance our knowledge about ARD. We have determined a structure of ARD from Homo sapiens with selenomethionine...
November 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29191782/comparison-of-the-hemodynamic-performance-of-the-balloon-expandable-sapien-3-versus-self-expandable-evolut-r-transcatheter-valve-a-case-matched-study
#7
Eduardo Enríquez-Rodríguez, Ignacio J Amat-Santos, Pilar Jiménez-Quevedo, Irene Martín-Morquecho, Gabriela Tirado-Conte, María José Pérez-Vizcayno, José Juan Gómez de Diego, Roman Arnold, Andrés Aldazábal, Paol Rojas, Alberto de Agustín, María Del Trigo, Hipólito Gutiérrez, José A San Román, Carlos Macaya, Luis Nombela-Franco
INTRODUCTION AND OBJECTIVES: The SAPIEN 3 (S3) valve and the Medtronic Evolut R (EVR) are second-generation transcatheter valves, designed to further reduce the rate of paravalvular aortic regurgitation (AoR). The aim of this study was to compare the 2 devices in terms of valve performance in a case-matched study with independent echocardiographic analysis. METHODS: Of a population of 201 patients who underwent transcatheter aortic valve implantation, 144 patients (S3, n = 80; EVR, n = 64) were matched according to aortic annulus diameter and aortic valve calcium score, as assessed by computed tomography...
November 27, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29185181/efficacy-and-safety-of-transcatheter-aortic-valve-implantation-with-edwards-sapien-3-and-xt-in-smaller-asian-anatomy
#8
Makoto Nakashima, Yusuke Watanabe, Hirofumi Hioki, Yugo Nara, Fukuko Nagura, Naoyoshi Hosogoe, Hideyuki Kawashima, Akihisa Kataoka, Shuji Otsuki, Kumiko Konno, Hiroyuki Kyono, Naoyuki Yokoyama, Ken Kozuma
We aimed to compare the efficacy and safety of transcatheter aortic valve implantation (TAVI) using Edwards SAPIEN 3 (S3) valve and SAPIEN XT) in smaller anatomy. The new generation S3 TAVI device has been used worldwide; however, its efficacy and safety in smaller Asian anatomy remain unknown. Between February 2014 and March 2017, 166 consecutive patients (S3, 54; XT, 112) were treated with balloon-expandable TAVI in a single center and their outcomes were analyzed. Median patient age was 85 (range: 81-88) years and mean body surface area was 1...
November 28, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29182764/balloon-expandable-transapical-transcatheter-aortic-valve-implantation-with-or-without-predilation-of-the-aortic-valve-results-of-a-multicentre-registry
#9
Justus Strauch, Daniel Wendt, Anno Diegeler, Martin Heimeshoff, Steffen Hofmann, David Holzhey, Frank Oertel, Thorsten Wahlers, Jana Kurucova, Martin Thoenes, Cornelia Deutsch, Peter Bramlage, Holger Schröfel
OBJECTIVES: To assess safety and efficacy of transapical transcatheter aortic valve implantation (TA-TAVI) in the absence of predilation using balloon aortic valvuloplasty (BAV). Predilation of the stenosed valve using BAV is a routine step in TA-TAVI; however, evidence supporting its clinical value is lacking, and several studies have linked it with higher complication rates. METHODS: A prospective, two-armed, multicentre registry (EASE-IT TA) to gather data on patients undergoing TA-TAVI with or without BAV, using the Edwards SAPIEN 3 valve was designed...
November 22, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29177619/two-step-approach-to-avoid-obstruction-of-the-coronary-ostium-during-transcatheter-aortic-valve-implantation-with-the-sapien-3
#10
Eiji Taguchi, Yutaka Konami, Hiroto Suzuyama, Yoko Horibata, Koichi Nakao, Tomohiro Sakamoto
No abstract text is available yet for this article.
November 25, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29172210/latest-generation-of-balloon-expandable-valve-the-edwards-sapien-3-valve-less-paravalvular-regurgitation-but-higher-transvalvular-pressure-gradients
#11
Kaveh Eghbalzadeh, Elmar W Kuhn, Anton Sabashnikov, Carolyn Weber, Parwis Baradaran Rahmanian, Florian Siedek, Victor Mauri, Tanja Rudolph, Stephan Baldus, Navid Madershahian, Thorsten C Wahlers
No abstract text is available yet for this article.
November 24, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29161307/repeat-polymorphisms-in-the-homo-sapiens-heme-oxygenase-1-gene-in-diabetic-and-idiopathic-gastroparesis
#12
Simon J Gibbons, Madhusudan Grover, Kyoung Moo Choi, Akhilesh Wadhwa, Adeel Zubair, Laura A Wilson, Yanhong Wu, Thomas L Abell, William L Hasler, Kenneth L Koch, Richard W McCallum, Linda A B Nguyen, Henry P Parkman, Irene Sarosiek, William J Snape, James Tonascia, Frank A Hamilton, Pankaj J Pasricha, Gianrico Farrugia
BACKGROUND: Idiopathic and diabetic gastroparesis in Homo sapiens cause significant morbidity. Etiology or risk factors have not been clearly identified. Failure to sustain elevated heme oxygenase-1 (HO1) expression is associated with delayed gastric emptying in diabetic mice and polymorphisms in the HO1 gene (HMOX1, NCBI Gene ID:3162) are associated with worse outcomes in other diseases. AIM: Our hypothesis was that longer polyGT alleles are more common in the HMOX1 genes of individuals with gastroparesis than in controls without upper gastrointestinal motility disorders...
2017: PloS One
https://www.readbyqxmd.com/read/29157596/molecular-epidemiology-and-phylogenetic-analysis-of-human-papillomavirus-infection-in-women-with-cervical-lesions-and-cancer-from-the-coastal-region-of-ecuador
#13
Cesar H Bedoya-Pilozo, Lex G Medina Magües, Maylen Espinosa-García, Martha Sánchez, Johanna V Parrales Valdiviezo, Denisse Molina, María A Ibarra, María Quimis-Ponce, Karool España, Karla E Párraga Macias, Nancy V Cajas Flores, Solon A Orlando, Jorge A Robalino Penaherrera, Peter Chedraui, Saul Escobar, Rita D Loja Chango, Cecibel Ramirez-Morán, Jasson Espinoza-Caicedo, Sunny Sánchez-Giler, Celia M Limia, Yoan Alemán, Yudira Soto, Vivian Kouri, Andrés C A Culasso, Inés Badano
The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases...
November 17, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29153810/edwards-sapien-3-valve-for-mitral-replacement-in-a-child-after-melody-valve-endocarditis
#14
Matteo Trezzi, Enrico Cetrano, Roberta Iacobelli, Adriano Carotti
We present the surgical implantation in mitral position of the Edwards Sapien 3 valve for prosthetic valve endocarditis in a severely ill child after multiple valve replacements. The procedure was safely performed and provided adequate hemodynamic results in the short term. This report highlights the excellent potential of Sapien 3 valve for the treatment of mitral valve disease in children with a mitral valve annulus of appropriate size. Of note, the use of the Sapien 3 valve should be considered when a bioprosthesis is required at the time of valve re-replacement...
December 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29153740/cost-effectiveness-of-transcatheter-aortic-valve-implantation-in-patients-with-aortic-stenosis-in-japan
#15
Satoshi Kodera, Arihiro Kiyosue, Jiro Ando, Issei Komuro
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a less invasive treatment for elderly patients with aortic stenosis. However, the cost of TAVI is a major issue. This study analyzed the cost effectiveness of TAVI in Japan. METHODS: We developed an economic model to evaluate the quality-adjusted life years (QALYs) and costs of TAVI, surgical aortic valve replacement (SAVR), and medical therapy over a 10-year time horizon from the perspective of Japanese public healthcare payers...
November 16, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29151491/early-safety-and-efficacy-of-transcatheter-aortic-valve-implantation-for-asian-nonagenarians-from-kmh-registry
#16
Mizuki Miura, Shinichi Shirai, Yukari Uemura, Hiroyuki Jinnouchi, Takashi Morinaga, Akihiro Isotani, Shun Watanabe, Masaomi Hayashi, Norihiko Kamioka, Atsushi Nagasawa, Shinichi Kakumoto, Katsuhiro Seo, Yoshio Arai, Michiya Hanyu, Kenji Ando
As Japan has one of the most rapidly aging populations in the world, transcatheter aortic valve implantation (TAVI) is likely to be performed in increasing numbers of older people. There is little information on either the efficacy or the safety of TAVI in nonagenarians in Asia.From October 2013 to June 2015, 112 consecutive patients underwent TAVI with Edwards SAPIEN XT valves in our institution. We compared 25 patients aged at least 90 years (mean 91.6 ± 1.7 years) with 87 patients aged under 90 years (mean 82...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29128473/transfemoral-aortic-valve-implantation-is-more-successful-with-the-edwards-sapien-3-compared-with-the-edwards-xt-for-the-treatment-of-symptomatic-severe-aortic-stenosis
#17
Birgid Gonska, Julia Seeger, Alexander Junker, Christoph Rodewald, Ulrike Trepte, Dominik Scharnbeck, Wolfgang Rottbauer, Jochen Wöhrle
BACKGROUND: Residual aortic regurgitation (AR) after transfemoral aortic valve implantation (TAVI) is associated with increased mortality. The new Edwards Sapien 3 valve (ES3) is designed to reduce paravalvular AR. AIM: To compare a new-generation and a late-generation balloon-expandable transcatheter heart valve. METHODS: In this study, 100 consecutive patients treated with the ES3 for symptomatic native severe aortic stenosis were compared with 100 consecutive patients treated with the Edwards Sapien XT valve (EXT); all valves were implanted via transfemoral access...
November 8, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29105689/-feasibility-and-safety-of-right-subclavian-access-for-edwards-sapien-3-balloon-expandable-transcatheter-aortic-valve-implantation
#18
Alessandro Iadanza, Marco Solari, Enrico Tucci, Carlo Pierli
Despite the technical advancements in transcatheter aortic valve implantation (TAVI), this procedure in patients with peripheral artery disease remains challenging and requires a patient-tailored management by the Heart Team. In-depth assessment of the patient's vascular anatomy is of utmost importance for the management of TAVI procedures with the aim to use the less invasive approach according to the specific patient characteristics. The trans-subclavian approach should be the preferred option in patients with femoral arterial disease undergoing TAVI; however, self-expandable valves have potential limitations, as in case of ascending aorta dilation and high implantation...
October 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29103606/comparison-of-1-year-survival-and-frequency-of-paravalvular-leakage-using-the-sapien-3-versus-the-sapien-xt-for-transcatheter-aortic-valve-implantation-for-aortic-stenosis
#19
Alexander Meyer, Axel Unbehaun, Mohanad Hamandi, Simon H Sündermann, Semih Buz, Christoph Klein, Christof Stamm, Volkmar Falk, Jörg Kempfert
Transcatheter aortic valve implantation shortcomings such as relevant paravalvular leakage (PVL) have been shown to negatively impact survival. The Sapien 3 prosthesis has added features to address these problems. We compared the functional performance of the Sapien 3 (S3) and its predecessor Sapien XT (XT), with a particular focus on PVL. We analyzed 601 patients presenting with severe native aortic valve stenosis treated with either Sapien XT (n = 405, 2011 to 2014, mean STS-PROM [Society of Thoracic Surgeons predicted risk of mortality] 11...
October 9, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29068137/clinical-and-procedural-outcomes-with-the-sapien-3-versus-the-sapien-xt-prosthetic-valves-in-transcatheter-aortic-valve-replacement-a-systematic-review-and-meta-analysis
#20
Ramyashree Tummala, Kinjal Banerjee, Kesavan Sankaramangalam, Stephanie Mick, Amar Krishnaswamy, Jonathon White, Maan Fares, Anand Mehta, Zoran Popovic, Lars G Svensson, Samir R Kapadia
OBJECTIVES: The SAPIEN 3 valve (S3V) was designed to overcome the shortcomings of its predecessor, the SAPIEN XT (SXT) valve. We conducted a meta-analysis to compare their clinical outcomes and procedural characteristics. METHODS: PUBMED, EMBASE, and Cochrane CENTRAL were searched by two independent reviewers. The clinical outcomes of interest were paravalvular leakage (PVL), major vascular complications (MVC), bleeding, acute kidney injury (AKI), device success, need for post dilation all-cause mortality and procedural details...
October 25, 2017: Catheterization and Cardiovascular Interventions
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