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JOURNAL ARTICLE
Takashi Nagasaka, Vivek Patel, Ofir Koren, Alon Shechter, Tarun Chakravarty, Wen Cheng, Hideki Ishii, Hasan Jilaihawi, Mamoo Nakamura, Raj R Makkar
INTRODUCTION: Paravalvular leak (PVL) is a severe complication of transcatheter aortic valve replacement (TAVR) that can lead to poor outcomes. TAVR-in-TAVR is a promising treatment for PVL; however, reports on its safety or efficacy are limited. In this study, we aimed to investigate the clinical outcomes of TAVR-in-TAVR using balloon-expandable prostheses for PVLs after TAVR. METHODS: We retrospectively analyzed data from patients who underwent TAVR-in-TAVR using balloon-expandable Sapien prostheses for PVL after an initial TAVR at our institution...
2024: Frontiers in Cardiovascular Medicine
#2
JOURNAL ARTICLE
Alessia Cavallo, Emanuela Camera, Grazia Bottillo, Miriam Maiellaro, Mauro Truglio, Federico Marini, Marlène Chavagnac-Bonneville, Aurélie Fauger, Eric Perrier, Flavia Pigliacelli, Mauro Picardo, Antonio Cristaudo, Maria Mariano
Atopic dermatitis (AD) is a composite disease presenting disruption of the skin permeability barrier (SPB) in the stratum corneum (SC). Recent evidence supports derangement of the sebaceous gland (SG) activity in the AD pathomechanisms. The objective of this study was to delineate profiles of both sebaceous and epidermal lipids and of aminoacids from SG-rich (SGR) and SG-poor (SGP) areas in AD. Both sebum and SC were sampled from SGR areas, while SC was sampled also from SGP areas in 54 adult patients with AD, consisting of 34 and 20 subjects, respectively with and without clinical involvement of face, and in 44 age and sex-matched controls...
March 2024: Experimental Dermatology
#3
JOURNAL ARTICLE
Clemens Eckel, Won-Keun Kim, Dagmar Sötemann, Christina Grothusen, Vedat Tiyerili, Guido Dohmen, Matthias Renker, Efstratios I Charitos, Christian W Hamm, Yeong-Hoon Choi, Albrecht Elsässer, Helge Möllmann, Johannes Blumenstein
BACKGROUND: Comparative data on transcatheter self-expanding ACURATE neo2 (NEO2) and balloon-expandable SAPIEN 3 Ultra prostheses in technically challenging anatomy of severe aortic valve calcified aortic annuli are scarce. METHODS: A total of 1987 patients with severe native aortic stenosis treated with the self-expanding NEO2 (n=1457) or balloon-expandable SAPIEN 3 Ultra (n=530) from January 2017 to April 2023 were evaluated. The primary end point was procedural outcome according to the Valve Academic Research Consortium 3 definitions...
March 26, 2024: Circulation. Cardiovascular Interventions
#4
JOURNAL ARTICLE
Rob Eerdekens, Suzanne Kats, Janneke Pc Grutters, Michelle Green, Judith Shore, Pascal Candolfi, Wija Oortwijn, Pim Van Der Harst, Pim Tonino
BACKGROUND: There is growing evidence to support the benefits of transcatheter aortic valve implantation (TAVI) over surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis (sSAS) who are at high- or intermediate-risk of surgical mortality. The PARTNER 3 trial showed clinical benefits with SAPIEN 3 TAVI compared with SAVR in patients at low risk of surgical mortality. Whether TAVI is also cost-effective compared with SAVR for low-risk patients in the Dutch healthcare system remains uncertain...
March 26, 2024: Cost Effectiveness and Resource Allocation: C/E
#5
JOURNAL ARTICLE
Georgios Chalikias, Soultana Foutzitzi, Dimitrios Stakos, Dimitrios Tziakas
An 83-year-old man with severe aortic stenosis underwent implantation of a 29-mm SAPIEN-3 (Edwards Lifesciences) transcatheter aortic valve (TAV) appropriately sized for an aortic annulus area of 543.6 mm2.
March 19, 2024: Journal of Invasive Cardiology
#6
Kazuki Mizutani, Masafumi Ueno, Genichi Sakaguchi, Gaku Nakazawa
BACKGROUND: There are a few case reports regarding transcatheter aortic valve implantation (TAVI) for deteriorated surgical homograft. CASE SUMMARY: We present a case of severe structural valve deterioration (SVD) of homograft surgical aortic valve presenting severe aortic regurgitation in an 84-year-old man with decompensated heart failure. We performed TAVI in homograft valve using 23 mm SAPIEN3 Ultra RESILIA. The resulting grade of paravalvular regurgitation was trace, the post-operative effective orifice area (EOA) was 1...
March 2024: European Heart Journal. Case Reports
#7
JOURNAL ARTICLE
David Meier, Daire Grant, Chris Frawley, Mariama Akodad, Uri Landes, Arif A Kokhar, Dariusz Dudek, Isaac George, Michael J Rinaldi, Won-Keun Kim, Steven J Yakubov, Paul Sorajja, Giuseppe Tarantini, David A Wood, John G Webb, Stephanie L Sellers, Janarthanan Sathananthan
BACKGROUND: There are limited data regarding treatment for failed balloon-expandable transcatheter heart valves (THVs) in redo-transcatheter aortic valve implantation (TAVI). AIMS: We aimed to assess THV performance, neoskirt height and expansion when performing redo-TAVI with the ACURATE platform inside a SAPIEN 3 (S3) compared to redo-TAVI with an S3 in an S3. METHODS: Redo-TAVI was performed on the bench using each available size of the S3, the ACURATE neo2 (ACn2) and the next-generation ACURATE Prime XL (AC XL) implanted at 2 different depths within 20 mm/23 mm/26 mm/29 mm S3s serving as the "failed" index THV...
March 18, 2024: EuroIntervention
#8
JOURNAL ARTICLE
Anoop N Koshy, Gilbert H L Tang, Sahil Khera, Manish Vinayak, Megan Berdan, Sneha Gudibendi, Amit Hooda, Lucy Safi, Stamatios Lerakis, George D Dangas, Samin K Sharma, Annapoorna S Kini, Parasuram Krishnamoorthy
BACKGROUND: Redo-transcatheter aortic valve replacement (TAVR) can pin the index transcatheter heart valve leaflets open leading to sinus sequestration and restricting coronary access. The impact of initial implant depth and commissural alignment on redo-TAVR feasibility is unclear. We sought to determine the feasibility of redo-TAVR and coronary access after SAPIEN 3 (S3) TAVR stratified by implant depth and commissural alignment. METHODS: Consecutive patients with native valve aortic stenosis were evaluated using multidetector computed tomography...
March 2024: Circulation. Cardiovascular Interventions
#9
Victor H Molina-Lopez, Eduardo Partida-Rodriguez, Jaime Rivera-Babilonia, Luis Rodriguez-Ospina
This study examines a complex scenario of structural valve degeneration (SVD) in a high surgical-risk patient with a previously implanted 25 mm Carpentier-Edwards (CE) Perimount Magna Ease 3300 (Irvine, CA: Edwards Lifesciences) surgical bioprosthetic valve (SAV), the patient presented with both paravalvular leak (PVL) and central prosthetic valve insufficiency (PVI). The patient was considered for a transaortic valve-in-valve (ViV) intervention with a self-expanding 29 mm Evolut R valve (Minneapolis, MN: Medtronic)...
February 2024: Curēus
#10
JOURNAL ARTICLE
Yang Li, Yizhong Wang, Cankun Wang, Anjun Ma, Qin Ma, Bingqiang Liu
In this study, we introduce TESA (weighted two-stage alignment), an innovative motif prediction tool that refines the identification of DNA-binding protein motifs, essential for deciphering transcriptional regulatory mechanisms. Unlike traditional algorithms that rely solely on sequence data, TESA integrates the high-resolution chromatin immunoprecipitation (ChIP) signal, specifically from ChIP-exonuclease (ChIP-exo), by assigning weights to sequence positions, thereby enhancing motif discovery. TESA employs a nuanced approach combining a binomial distribution model with a graph model, further supported by a "bookend" model, to improve the accuracy of predicting motifs of varying lengths...
March 8, 2024: Patterns
#11
JOURNAL ARTICLE
Viktória Stanová, Régis Rieu, Lionel Thollon, Erwan Salaun, Josep Rodés-Cabau, Nancy Côté, Diego Mantovani, Philippe Pibarot
BACKGROUND: It is unknown whether bioprostheses used for transcatheter aortic valve implantation will have similar long-term durability as those used for surgical aortic valve replacement. Repetitive mechanical stress applied to the valve leaflets, particularly during diastole, is the main determinant of structural valve deterioration. Leaflet mechanical stress cannot be measured in vivo. The objective of this in vitro/in silico study was thus to compare the magnitude and regional distribution of leaflet mechanical stress in old vs new generations of self-expanding (SE) vs balloon expandable (BE) transcatheter heart valves (THVs)...
March 2024: Structural heart: the journal of the Heart Team
#12
JOURNAL ARTICLE
Andrea Scotti, Matteo Sturla, Giuliano Costa, Francesco Saia, Thomas Pilgrim, Mohamed Abdel-Wahab, Philippe Garot, Caterina Gandolfo, Luca Branca, Ignacio Amat Santos, Darren Mylotte, Francesco Bedogni, Ole De Backer, Luis Nombela Franco, John Webb, Flavio Luciano Ribichini, Andrea Mainardi, Stefano Andreaggi, Alessandro Mazzapicchi, Daijiro Tomii, Pietro Laforgia, Stefano Cannata, Claudia Fiorina, Simone Fezzi, Enrico Criscione, Mattia Lunardi, Enrico Poletti, Mattia Mazzucca, Angelo Quagliana, Nicholas Montarello, Breda Hennessey, Matias Mon-Noboa, Myriam Akodad, David Meier, Federico De Marco, Marianna Adamo, Carmelo Sgroi, Claudia Maria Reddavid, Roberto Valvo, Orazio Strazzieri, Silvia Crescenzia Motta, Valentina Frittitta, Elena Dipietro, Alessandro Comis, Chiara Melfa, Mariachiara Calì, Sofia Sammartino, Giulia Laterra, Holger Thiele, Lars Sondergaard, Corrado Tamburino, Marco Barbanti, Azeem Latib
BACKGROUND: The performance of latest iteration transcatheter aortic valve replacement platforms in patients with small aortic anatomy remains underexplored. OBJECTIVES: The aim of this study was to evaluate effectiveness and performance between the self-expanding (SE) Evolut PRO and PRO+ and the balloon-expandable (BE) SAPIEN ULTRA in patients with small aortic annuli. METHODS: Data from the OPERA-TAVI (Comparative Analysis of Evolut PRO vs...
March 11, 2024: JACC. Cardiovascular Interventions
#13
REVIEW
Adham H El Sherbini, Maria Servito, Ali Zidan, Salma Elsherif, Grace Ko, Islam Y Elgendy, Lina Ya'Qoub
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is a reasonable therapeutic approach among patients with symptomatic severe aortic stenosis irrespective of surgical risk. Data regarding sex-specific differences in the outcomes with newer generation valves are limited. METHODS: Electronic databases were searched for studies assessing sex differences in the outcomes of patients undergoing TAVR with newer generation valves (SAPIEN 3 or Evolut). Random effects model was constructed for summary estimates...
March 10, 2024: Catheterization and Cardiovascular Interventions
#14
JOURNAL ARTICLE
Right transaxillary transcatheter aortic valve replacement is comparable to left despite challenges.
Daniel McGrath, Hansuh Lee, Charley Sun, Masashi Kawabori, Yong Zhan
OBJECTIVES: Transaxillary access is the most popular alternative to transfemoral transcatheter aortic valve replacement. Although left transaxillary access is generally preferred, right transaxillary transcatheter aortic valve replacement could be challenging because of the opposing axillary artery and aortic curvatures, which may warrant procedural modifications to improve alignment. Our aim is to compare our single center's outcomes for left and right transaxillary access groups and to evaluate procedural modifications for facilitating right transaxillary transcatheter aortic valve replacement...
March 9, 2024: General Thoracic and Cardiovascular Surgery
#15
JOURNAL ARTICLE
Curtiss T Stinis, Amr E Abbas, Paul Teirstein, Raj R Makkar, Christine J Chung, Vijay Iyer, Philippe Généreux, Robert M Kipperman, John K Harrison, G Chad Hughes, Jefferson M Lyons, Ayaz Rahman, Nikolaos Kakouros, Jennifer Walker, David K Roberts, Pei-Hsiu Huang, Biswajit Kar, Abhijeet Dhoble, Daniel P Logsdon, Puneet K Khanna, Joseph Aragon, James M McCabe
BACKGROUND: The fifth-generation SAPIEN 3 Ultra Resilia valve (S3UR) incorporates several design changes as compared with its predecessors, the SAPIEN 3 (S3) and SAPIEN 3 Ultra (S3U) valves, including bovine leaflets treated with a novel process intended to reduce structural valve deterioration via calcification, as well as a taller external skirt on the 29-mm valve size to reduce paravalvular leak (PVL). The clinical performance of S3UR compared with S3 and S3U in a large patient population has not been previously reported...
February 29, 2024: JACC. Cardiovascular Interventions
#16
JOURNAL ARTICLE
Xinmei Yang, Yuyun Dong, Yu Wang, Shanxin Liu, Xiaohong Huang, Youhua Huang, Qiwei Qin
Stimulator of interferon gene (STING) plays a crucial role in the innate immune response against viral and bacterial pathogens. However, its function in largemouth bass iridovirus (LMBV) infection remains uncertain. Here, a STING homolog (MsSTING) from largemouth bass (Micropterus salmoides) was cloned and characterized. MsSTING encoded a 407-amino-acid polypeptide, which shared 84.08% and 41.45% identity with golden perch (Perca flavescens) and human (Homo sapiens) homologs, respectively. MsSTING contained four transmembrane domains and a conserved C-terminal domain...
March 5, 2024: Fish & Shellfish Immunology
#17
JOURNAL ARTICLE
Christophe Dubois, Tom Adriaenssens, Lieven Annemans, Johan Bosmans, Britt Callebaut, Pascal Candolfi, Kristoff Cornelis, Alexis Delbaere, Michelle Green, Joelle Kefer, Patrizio Lancellotti, Michael Rosseel, Judith Shore, Jan Van Der Heyden, Sebastian Vermeersch, Eric Wyffels
BACKGROUND: Transcatheter aortic valve implantation (TAVI) with the SAPIEN 3 device has recently shown significant clinical benefits, compared to surgical aortic valve replacement (SAVR), in patients at low risk for surgical mortality (PARTNER 3 trial, NCT02675114). Currently in Belgium, TAVI use is restricted to high-risk or inoperable patients with severe symptomatic aortic stenosis (sSAS). This cost-utility analysis aimed to assess whether TAVI with SAPIEN 3 could lead to potential cost-savings compared with SAVR, in the low-risk sSAS population in Belgium...
February 2024: Acta Cardiologica
#18
Ijeoma Orabueze, Olushola Ogunleye, Mark Harrison
The pathophysiology of aortic valve stenosis is degenerative and calcific. It may be exacerbated by atherosclerotic processes characterized by lipid accumulation and inflammation. When the stenosis gets hemodynamically severe, the valves would need to be replaced. They could be replaced using mechanical or bioprosthetic heart valves. Balloon-expandable (BE) transcatheter heart valves (THVs) were compared to the self-expanding (SE) THVs and it was found that the rate of bioprosthetic valve failure was low over a five-year period...
February 2024: Curēus
#19
JOURNAL ARTICLE
Parker J Nichols, Robb Welty, Jeffrey B Krall, Morkos A Henen, Quentin Vicens, Beat Vögeli
The left-handed Z-conformation of nucleic acids can be adopted by both DNA and RNA when bound by Zα domains found within a variety of viral and innate immune response proteins. While Z-form adoption is preferred by certain sequences, such as the commonly studied (CpG)n repeats, Zα has been reported to bind to a wide range of sequence contexts. Studying how Zα interacts with B-/A-form helices prior to their conversion to the Z-conformation is challenging as binding coincides with Z-form adoption...
March 4, 2024: Biochemistry
#20
Victor H Molina-Lopez, Ismael Ortiz-Cartagena, Josue Mercado-Crespo, Miguel A Campos-Esteve
Transcatheter aortic valve replacement (TAVR) has increasingly become a fundamental approach for treating aortic valve stenosis (AVS), especially in high surgical risk patients. This case study underscores the criticality of meticulous procedural planning and precise valve selection in patients with severe AVS compounded by obesity. We report a case of a patient who, after receiving a 26 mm Edwards Sapiens 3 valve, presented with worsening exertional dyspnea and a declining indexed effective orifice area (EOAi)...
January 2024: Curēus
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