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https://www.readbyqxmd.com/read/28283746/predictors-for-permanent-pacemaker-implantation-in-patients-undergoing-transfemoral-aortic-valve-implantation-with-the-edwards-sapien-3-valve
#1
Birgid Gonska, Julia Seeger, Mirjam Keßler, Alexander von Keil, Wolfgang Rottbauer, Jochen Wöhrle
BACKGROUND: Predictors for the need of permanent pacemaker implantation (PPMI) in the context of transcatheter aortic valve implantation (TAVI) are not well defined yet. We evaluated the impact of conduction disturbances, calcium volume of the device landing zone, oversizing and implantation depth on PPMI after TAVI with the balloon-expandable Edwards Sapien 3 (ES3). METHODS AND RESULTS: 335 consecutive patients undergoing transfemoral TAVI with the ES3 for the treatment of symptomatic severe aortic stenosis were included (clinicaltrials NCT02162069)...
March 10, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28279501/long-term-follow-up-after-trans-catheter-tricuspid-valve-in-valve-replacement-with-balloon-expandable-aortic-valves
#2
Roberto Scarsini, Mattia Lunardi, Gabriele Pesarini, Fausto Castriota, Mauro Feola, Valeria Ferrero, Giuseppe Faggian, Corrado Vassanelli, Flavio Ribichini
BACKGROUND: Transcatheter tricuspid VIV replacement has been proposed as a feasible option for high-risk patients with previous tricuspid valve replacement that undergo valve degeneration causing refractory heart failure. However, little is known about the long-term outcome of patients treated with transcatheter tricuspid VIV. We evaluate the safety of transcatheter tricuspid valve-in-valve (VIV) replacement by using balloon-expandable aortic valve stents and the long-term follow-up. METHODS AND RESULTS: From January 2013 to March 2016, 4 patients underwent transcatheter tricuspid VIV in our center using balloon-expandable Edwards Sapien-XT and Sapien-3 valves...
February 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28279376/trials-testing-the-value-of-imaging-use-in%C3%A2-valve-disease-and-in-transcatheter-valvular-interventions
#3
REVIEW
Jonathon Leipsic, Jeroen J Bax, John G Webb, Randolph Martin, Philipp Blanke
The role of imaging in the diagnosis of valvular heart disease is well established through years of investigation and validation. However, the role of imaging in guiding the treatment decision-making for valvular heart disease is less well established, and there is a striking paucity of randomized trial data to help inform these decisions. Given this relative absence of randomized trial data, the present article highlights some of the most important knowledge gaps and defines meaningful opportunities for the field to help advance the care of patients with valvular heart disease in a cost-effective fashion...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28279319/infective-endocarditis-risk-after-percutaneous-pulmonary-valve-implantation-with-the-melody-and%C3%A2-sapien%C3%A2-valves
#4
Sebastien Hascoet, Lucia Mauri, Caroline Claude, Emmanuelle Fournier, Julie Lourtet, Jean-Yves Riou, Philippe Brenot, Jérôme Petit
OBJECTIVES: This study compared the risk of infective endocarditis (IE) after percutaneous pulmonary valve implantation (PPVI) with the Sapien and Melody valves. BACKGROUND: The incidence of IE after PPVI is estimated at 3% per year with the Melody valve. The Sapien valve is a more recently marketed valve used for PPVI. METHODS: We retrospectively included consecutive patients who underwent PPVI at a single center between 2008 and 2016. IE was diagnosed using the modified DUKE criteria...
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28258051/transcatheter-heart-valve-selection-and-permanent-pacemaker-implantation-in-patients-with-pre-existent-right-bundle-branch-block
#5
Lennart van Gils, Didier Tchetche, Thibault Lhermusier, Masieh Abawi, Nicolas Dumonteil, Ramón Rodriguez Olivares, Javier Molina-Martin de Nicolas, Pieter R Stella, Didier Carrié, Peter P De Jaegere, Nicolas M Van Mieghem
BACKGROUND: Right bundle branch block is an established predictor for new conduction disturbances and need for a permanent pacemaker (PPM) after transcatheter aortic valve replacement. The aim of the study was to evaluate the absolute rates of transcatheter aortic valve replacement related PPM implantations in patients with pre-existent right bundle branch block and categorize for different transcatheter heart valves. METHODS AND RESULTS: We pooled data on 306 transcatheter aortic valve replacement patients from 4 high-volume centers in Europe and selected those with right bundle branch block at baseline without a previously implanted PPM...
March 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28248409/immediate-and-long-term-outcomes-of-percutaneous-transcatheter-pulmonary-valve-implantation
#6
Roland Fiszer, Paweł Dryżek, Małgorzata Szkutnik, Sebastian Góreczny, Alexandra Krawczuk, Jadwiga Moll, Tomasz Moszura, Szymon Pawlak, Jacek Białkowski
BACKGROUND: Transcutaneous pulmonary valve replacement (TPVR) has become an alternative to heart surgery for patients after previous right ventricular outflow tract (RVOT) or pulmonary artery (PA) surgical interventions. The objective was to present immediate and long-term outcomes of transcutaneous pulmonary valve replacement. METHODS: Between 06/2009 and 06/2016, 46 patients underwent TPVR. Initial diagnoses included tetralogy of Fallot, common arterial trunk, transposition of great arteries post Rastelli correction, left ventricle outflow obstruction after Ross operation, pulmonary atresia, and isolated dysplastic pulmonary valve stenosis...
March 1, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28247468/discovery-and-quantitative-structure-activity-relationship-study-of-lepidopteran-hmg-coa-reductase-inhibitors-as-selective-insecticides
#7
Yang-Yang Zang, Yuan-Mei Li, Yue Yin, Shan-Shan Chen, Zhen-Peng Kai
BACKGROUND: In the previous study, we have demonstrated that insect 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) can be a potential selective insecticide target. Three series of inhibitors were designed based on the difference of HMGR structures from Homo sapiens and Manduca sexta with the aim for discovering potent selective insecticide candidate. RESULTS: Bioassay in vitro showed that gem-difluoromethylenated statin analogs have potent effects on JH biosynthesis of M...
March 1, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28209261/the-feasibility-of-transcatheter-aortic-valve-implantation-using-the-edwards-sapien-3-for-patients-with-severe-bicuspid-aortic-stenosis
#8
Takahide Arai, Thierry Lefèvre, Thomas Hovasse, Marie-Claude Morice, Mauro Romano, Hakim Benamer, Philippe Garot, Kentaro Hayashida, Erik Bouvier, Bernard Chevalier
BACKGROUND: There are currently only limited data focusing on transcatheter aortic valve implantation (TAVI) for bicuspid aortic valves (BAV) patients using the Edwards SAPIEN (Irvine, CA, USA) 3 (S3) valve. The aim of this study was to evaluate the feasibility and efficacy of TAVI using the S3 in patients with BAV. METHODS: A total of 153 TAVI cases performed with the S3 were included. BAV was detected by multidetector computed tomography (MDCT) in 10 (7%) patients...
February 10, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28180241/leaflet-protrusion-into-left-main-coronary-artery-detected-by-intravascular-ultrasound-after-transcatheter-aortic-valve-implantation-with-sapien-3
#9
Shunsuke Kubo, Yasushi Fuku, Takeshi Shimamoto, Tsuyoshi Goto, Kazushige Kadota
No abstract text is available yet for this article.
February 9, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28179071/the-bh4-domain-of-bcl-2-orthologues-from-different-classes-of-vertebrates-can-act-as-an-evolutionary-conserved-inhibitor-of-ip3-receptor-channels
#10
Hristina Ivanova, Tomas Luyten, Elke Decrock, Tim Vervliet, Luc Leybaert, Jan B Parys, Geert Bultynck
Ca(2+) signalling plays an important role in various physiological processes in vertebrates. In mammals, the highly conserved anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein is an important modulator of the inositol 1,4,5-trisphosphate receptor (IP3R), i.e. the main intracellular Ca(2+) - release channel located at the endoplasmic reticulum (ER). The Bcl-2 Homology (BH) 4 domain of Bcl-2 (BH4-Bcl-2) is a critical determinant for inhibiting IP3Rs, by directly targeting a region in the modulatory domain of the receptor (domain 3)...
January 25, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28164008/transcatheter-aortic-valve-replacement-with-the-sapien-3-valve-preparing-the-field-for-the-final-expansion
#11
EDITORIAL
Jean-Michel Paradis, Josep Rodés-Cabau
No abstract text is available yet for this article.
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28162223/impact-of-subclinical-vascular-complications-detected-by-systematic-postprocedural-multidetector-computed-tomography-after-transcatheter-aortic-valve-implantation-using-balloon-expandable-edwards-sapien-xt-heart-valve
#12
Yuki Kakefuda, Kentaro Hayashida, Yoshitake Yamada, Fumiaki Yashima, Taku Inohara, Ryo Yanagisawa, Makoto Tanaka, Takahide Arai, Takashi Kawakami, Yuichiro Maekawa, Hikaru Tsuruta, Yuji Itabashi, Mitsushige Murata, Motoaki Sano, Kazuma Okamoto, Akihiro Yoshitake, Hideyuki Shimizu, Masahiro Jinzaki, Keiichi Fukuda
Complications after transcatheter aortic valve implantation (TAVI) remain an important issue. This study aimed to evaluate the impact of systematic postprocedural multidetector computed tomography (MDCT) to detect subclinical complications after TAVI. From October 2013 to August 2015, a total of 135 patients who underwent transfemoral TAVI (n = 116) or transapical TAVI (n = 19) with Sapien XT and MDCT preprocedure and postprocedure were enrolled. Postprocedural MDCT findings were compared with the preprocedural MDCT findings...
April 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28159378/valve-in-valve-implantation-of-a-sapien-3-transcatheter-heart-valve-for-reduction-of-paravalvular-regurgitation-despite-optimal-placement-of-the-first-transcatheter-heart%C3%A2-valve
#13
Ayoub El Hammiri, Jeannot Potvin, Jean-François Gobeil, Nicolas Noiseux, Louis-Mathieu Stevens, Jean-Bernard Masson
Valve-in-valve implantation is generally successful in reducing paravalvular regurgitation (PVR) in cases in which the first transcatheter heart valve is deployed in a suboptimal location. We describe a case of severe PVR 2 months after implantation of a 26-mm Sapien XT valve (Edwards Lifesciences Inc, Irvine, CA) in the optimal location. Valve-in-valve implantation of a Sapien 3 valve (Edwards Lifesciences Inc), and enough left ventricular outflow tract tissue at the inflow edge the Sapien XT to appose the sealing cuff of the Sapien 3 combined for successful PVR treatment...
November 29, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28128540/determinants-of-aortic-regurgitation-after-transcatheter-aortic-valve-implantation-an-observational-study-using-multi-slice-computed-tomography-msct-guided-sizing
#14
Zouhair Rahhab, Nahid El Faquir, Ramón Rodríguez-Olivares, Claire Ren, Nicolas VAN Mieghem, Marcel L Geleijnse, Carl Schultz, Ron VAN Domburg, Peter P DE Jaegere
BACKGROUND: To explore the determinants of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) using Multi Slice Computed Tomography (MSCT) instead of echocardiography-guided sizing. METHODS: Determinants of AR were assessed in 313 consecutive patients who underwent TAVI with the Medtronic(MCS, n=259) or Edwards Sapien or XT(ESV, n=54) using MSCT- guided sizing. AR was assessed by angiography immediately after TAVI (n=313, Sellers) and by echocardiography at discharge (n=285, VARC-2)...
January 27, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28123149/clinical-outcomes-and-bioprosthetic-valve-function-after-transcatheter-aortic-valve-implantation-under-dual-antiplatelet-therapy-vs-aspirin-alone
#15
Yasuhiro Ichibori, Isamu Mizote, Koichi Maeda, Toshinari Onishi, Tomohito Ohtani, Osamu Yamaguchi, Kei Torikai, Toru Kuratani, Yoshiki Sawa, Satoshi Nakatani, Yasushi Sakata
BACKGROUND: Dual antiplatelet therapy (DAPT) is commonly used after transcatheter aortic valve implantation (TAVI); however, the supporting evidence is limited. To determine if aspirin alone is a better alternative to DAPT, we compared the outcomes of patients treated with DAPT or aspirin alone after TAVI.Methods and Results:We analyzed a total of 144 consecutive patients (92 females, mean age 83±6 years) who underwent implantation of a balloon-expandable transcatheter valve (SAPIEN or SAPIEN XT, Edwards Lifesciences)...
February 24, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28117281/optimal-sizing-for-sapien-3-transcatheter-aortic-valve-replacement-in-patients-with-or-without-left-ventricular-outflow-tract-calcification
#16
Yoshio Maeno, Yigal Abramowitz, Hasan Jilaihawi, Sharjeel Israr, Sunghan Yoon, Rahul P Sharma, Yoshio Kazuno, Hiroyuki Kawamori, Masaki Miyasaka, Tanya Rami, Geeteshwar Mangat, Nobuyuki Takahashi, Kazuaki Okuyama, Mohammad Kashif, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Raj R Makkar
AIMS: The impact of left ventricular outflow tract calcification (LVOT-CA) on Sapien 3 transcatheter aortic valve replacement (S3-TAVR) is not well understood. The aims of the present study were to determine optimal device sizing for S3-TAVR in patients with or without LVOT-CA and to evaluate the influence of residual paravalvular leak (PVL) on survival after S3-TAVR in these patients. METHODS AND RESULTS: This study analyzed 280 patients (LVOT-CA=144, no LVOT-CA=136) undergoing S3-TAVR...
January 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28108064/stent-and-leaflet-stresses-in-a-26-mm-first-generation-balloon-expandable-transcatheter-aortic-valve
#17
Yue Xuan, Kapil Krishnan, Jian Ye, Danny Dvir, Julius M Guccione, Liang Ge, Elaine E Tseng
OBJECTIVE: Transcatheter aortic valve replacement is established therapy for high-risk and inoperable patients with severe aortic stenosis, but questions remain regarding long-term durability. Valve design influences durability. Increased leaflet stresses in surgical bioprostheses have been correlated with degeneration; however, transcatheter valve leaflet stresses are unknown. From 2007 to 2014, a majority of US patients received first-generation balloon-expandable transcatheter valves...
December 23, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28106026/successful-simultaneous-ipsilateral-stenting-of-common-iliac-artery-stenosis-and-transfemoral-aortic-valve-replacement
#18
Abdullah Nabi Aslan, Hacı Ahmet Kasapkara, Serkan Sivri, Murat Can Güney, Engin Bozkurt
Transcatheter aortic valve replacement (TAVR) was designed to treat elderly patients with severe aortic stenosis at high risk for surgery, and is most commonly performed with retrograde approach through femoral arteries. However, in up to 30% of cases, it is either not possible to use this access route or it is considered to have high risk of vascular injury. Alternative approaches have been described for patients with no suitable femoral access: trans-subclavian, transaortic, or direct aortic access; however, since the introduction of new valves deployed with low-profile delivery systems, another alternative transcatheter approach has been discovered...
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28105998/simultaneous-transfemoral-aortic-and-transseptal-mitral-valve-replacement-utilising-sapien-3-valves-in-native-aortic-and-mitral-valves
#19
Mohammad Bashir, Gardar Sigurdsson, Phillip A Horwitz, Firas Zahr
AIMS: Concomitant severe calcific aortic and mitral stenosis is a relatively uncommon but very challenging valvular heart disease to manage. We sought to evaluate the feasibility of a fully percutaneous approach to replace both stenotic native mitral and aortic valves using SAPIEN 3 valves. METHODS AND RESULTS: An 87-year-old woman with chronic kidney disease stage 3, pul-monary hypertension, chronic obstructive pulmonary disease, a permanent pacemaker, and atrial fibrillation was referred with Class III heart failure symptoms...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28105997/first-successful-transcatheter-double-valve-replacement-from-a-transapical-access-and-nine-month-follow-up
#20
Robert Bauernschmitt, Stefan Bauer, Christian Liewald, Ramiz Emini, Wolfgang Oechsner, Meinrad Beer, Ralf Sodian, Andreas Liebold
AIMS: While TAVI is the treatment of choice in patients with aortic stenosis considered inoperable or at high risk, interventional replacement of the mitral valve is still in the preclinical or early clinical phase. Our aim was to report on the first transcatheter double valve replacement into native valves from a transapical access. METHODS AND RESULTS: A 67-year-old, highly symptomatic female patient considered inoperable due to severe calcification of the mitral annulus and comorbidities was scheduled for transcatheter double valve replacement by the local Heart Team...
January 20, 2017: EuroIntervention
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