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https://www.readbyqxmd.com/read/28551917/-holocaust-doctors-survivors-in-israel-1945-1952-from-early-positions-to-professional-integration
#1
Rachel Herzog
INTRODUCTION: The encounter between Holocaust doctor survivors and the Israeli society was part of the whole encounter between Holocaust survivors and the Israeli society. The present thesis aimed at evaluating the integration process of Holocaust doctor survivors in the Israeli health care system from 1945 until the end of 1952. Between these years about 1350 doctors arrived in Israel, the vast majority of them Holocaust survivors. CONCLUSIONS: Their rapid entrance to work provided the healthcare system with professional manpower, contributing their share during a tough period of the nation's history...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551911/-extrinsic-and-intrinsic-factors-for-falls-that-caused-hip-fracture
#2
Atzmon Tsur, Nael Shakeer, Zvi Segal, Dorit Itah, Dana Eluz
INTRODUCTION: Among the reasons described as possibly causing falls in older and elderly people are extrinsic factors such as bumping into objects, slipping on a wet floor, etc., and intrinsic factors - those that occur suddenly without warning. OBJECTIVES: To investigate the connection between the reasons for falls, extrinsic or intrinsic and different medical and nonmedical factors. METHODS: The survey included 82 people, 53 women and 29 men, who fell and broke their hip, underwent surgery, and were treated at the Rehabilitation Department...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551909/-dermatological-diseases-in-elderly-hospitalized-patients-in-the-galilee-medical-center-comparison-between-two-age-groups
#3
Maayan Lahav Sher, Orly Yakir, Ora Bitterman-Deutsch
INTRODUCTION: Although dermatologic conditions bring relatively few people to the Emergency Department, hospitalized patients, especially older people, often suffer from skin problems that contribute to their morbidity. AIMS: We wanted to identify the frequency, clinical course, treatment and influence on hospitalization of dermatologic conditions in patients hospitalized in internal and geriatric departments in Galilee Medical Center. We concentrated on two groups of adults, aged 40-65 years (adult group) and above 65 years (elderly group), in order to understand differences in the cause of referral, type of diagnosis and mode of treatment...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551896/-review-of-common-pathogens-in-the-bone-and-blood-cultures-and-antibiotic-treatment-in-patients-with-sternal-osteomyelitis
#4
Michal Benkler, Ori Shulman, Yoav Avrahamy, David Mendes, Yoav Arus, Ron Fishel, Amos Leviav, Dana Egozi
AIMS: This study concentrates on microbiological data collection of deep sternal wounds to delineate early and correct antibiotic therapy. BACKGROUND: Deep sternal wound infection, mediastinitis and sternal osteomyelitis are devastating and life-threatening complications of median-sternotomy incisions after cardiac surgical procedures. The incidence of surgical wound infection in sternotomies should be similar to that in any clean surgical procedure (i.e. approximately 2%)...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551882/medical-geology-of-endemic-goiter-in-kalutara-sri-lanka-distribution-and-possible-causes
#5
G W A R Fernando, P L C L Liyanage, Anushka Upamali Rajapaksha, Meththika Vithanage
This study assesses the distribution of goiter in the Kalutara District, Sri Lanka in order to find causative factors for the occurrence of goiter even after the salt iodization. A questionnaire survey was conducted at the household level and at the same time iodine and selenium levels of the water sources were analyzed. Questionnaire survey results indicated the highest numbers of goiter patients in the northern part where the lowest were found in the southern sector which may be due to the presence of acid sulfate soils...
May 27, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28551875/non-ureolytic-calcium-carbonate-precipitation-by-lysinibacillus-sp-ys11-isolated-from-the-rhizosphere-of-miscanthus-sacchariflorus
#6
Yun Suk Lee, Hyun Jung Kim, Woojun Park
Although microbially induced calcium carbonate precipitation (MICP) through ureolysis has been widely studied in environmental engineering fields, urea utilization might cause environmental problems as a result of ammonia and nitrate production. In this study, many non-ureolytic calcium carbonate-precipitating bacteria that induced an alkaline environment were isolated from the rhizosphere of Miscanthus sacchariflorus near an artificial stream and their ability to precipitate calcium carbonate minerals with the absence of urea was investigated...
June 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28551857/efficient-enzymatic-degradation-used-as-pre-stage-treatment-for-norfloxacin-removal-by-activated-sludge
#7
Ruinan Zhao, Xiaohong Li, Mancheng Hu, Shuni Li, Quanguo Zhai, Yucheng Jiang
Norfloxacin is often found in wastewater treatment plants, groundwater, and even drinking water causing environmental concerns because of its potential undesirable effects on human health or aquatic ecosystems. However, conventional treatments cannot deal with norfloxacin efficiently. This work proposes an efficiently enzymatic degradation of norfloxacin by chloroperoxidase (CPO). 82.18% degradation efficiency of norfloxacin was achieved after 25 min reaction time at pH 5.0 with an enzyme concentration of 1...
May 27, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28551824/the-role-of-the-atp2c1-gene-in-hailey-hailey-disease
#8
REVIEW
Hao Deng, Heng Xiao
Hailey-Hailey disease (HHD) is a rare autosomal dominant acantholytic dermatosis, characterized by a chronic course of repeated and exacerbated skin lesions in friction regions. The pathogenic gene of HHD was reported to be the ATPase calcium-transporting type 2C member 1 gene (ATP2C1) located on chromosome 3q21-q24. Its function is to maintain normal intracellular concentrations of Ca(2+)/Mn(2+) by transporting Ca(2+)/Mn(2+) into the Golgi apparatus. ATP2C1 gene mutations are reportedly responsible for abnormal cytosolic Ca(2+)/Mn(2+) levels and the clinical manifestations of HHD...
May 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28551817/discovery-of-novel-inhibitors-for-leishmania-nucleoside-diphosphatase-kinase-ndk-based-on-its-structural-and-functional-characterization
#9
Arjun K Mishra, Nidhi Singh, Pragati Agnihotri, Shikha Mishra, Saurabh P Singh, Bala K Kolli, Kwang Poo Chang, Amogh A Sahasrabuddhe, M I Siddiqi, J Venkatesh Pratap
Nucleoside diphosphate kinases (NDKs) are ubiquitous enzymes that catalyze the transfer of the γ-phosphate moiety from an NTP donor to an NDP acceptor, crucial for maintaining the cellular level of nucleoside triphosphates (NTPs). The inability of trypanosomatids to synthesize purines de novo and their dependence on the salvage pathway makes NDK an attractive target to develop drugs for the diseases they cause. Here we report the discovery of novel inhibitors for Leishmania NDK based on the structural and functional characterization of purified recombinant NDK from Leishmania amazonensis...
May 27, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28551786/mitochondrial-bioenergetics-during-ischemia-and-reperfusion
#10
Alicia E Consolini, María I Ragone, Patricia Bonazzola, Germán A Colareda
During ischemia and reperfusion (I/R) mitochondria suffer a deficiency to supply the cardiomyocyte with chemical energy, but also contribute to the cytosolic ionic alterations especially of Ca(2+). Their free calcium concentration ([Ca(2+)]m) mainly depends on mitochondrial entrance through the uniporter (UCam) and extrusion in exchange with Na(+) (mNCX) driven by the electrochemical gradient (ΔΨm). Cardiac energetic is frequently estimated by the oxygen consumption, which determines metabolism coupled to ATP production and to the maintaining of ΔΨm...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551775/lbec0101-a-proposed-etanercept-biosimilar-pharmacokinetics-immunogenicity-and-tolerability-profiles-compared-with-a-reference-biologic-product-in-healthy-male-subjects
#11
Heechan Lee, Hyewon Chung, SeungHwan Lee, Howard Lee, Sung Mo Yang, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu
OBJECTIVES: We performed this study to compare the pharmacokinetic (PK), immunogenicity, and tolerability profiles of etanercept between LBEC0101, a proposed biosimilar, and Enbrel(®), the reference biological product. METHODS: A randomized, double-blind, single-dose, two-treatment, two-period, two-sequence, crossover study was conducted in 48 healthy males. In each period, a single dose of LBEC0101 or Enbrel(®) was subcutaneously injected at 25 mg and serial blood samples for PK evaluation were collected up to 648 h post-dose...
May 27, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28551746/occurrence-removal-and-risk-assessment-of-antibiotics-in-12-wastewater-treatment-plants-from-dalian-china
#12
Xin Zhang, Hongxia Zhao, Juan Du, Yixuan Qu, Chen Shen, Feng Tan, Jingwen Chen, Xie Quan
In this study, the occurrence and removal efficiencies of 31 antibiotics, including 11 sulfonamides (SAs), five fluoroquinolones (FQs), four macrolides (MLs), four tetracyclines (TCs), three chloramphenicols (CAPs), and four other antibiotics (Others), were investigated in 12 municipal wastewater treatment plants (WWTPs) in Dalian, China. A total of 29 antibiotics were detected in wastewater samples with the concentration ranging from 63.6 to 5404.6 ng/L. FQs and SAs were the most abundant antibiotic classes in most wastewater samples, accounting for 42...
May 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28551742/human-health-risk-exposure-with-respect-to-particulate-bound-polycyclic-aromatic-hydrocarbons-at-mine-fire-affected-coal-mining-complex
#13
Debananda Roy, Yong-Chil Seo, Sweta Sinha, Abir Bhattacharya, Gurdeep Singh, Pallab Kr Biswas
Particulate-bound poly-aromatic hydrocarbons (PAHs) are of great concern due to their mutagenicity and carcinogenicity effect on human health. In this context, identification, quantification and inhalation cancer risk (ICR) assessment due to PM10- and PM2.5-bound PAHs has been carried out at six monitoring stations in a critically polluted Jharia coalfield/Dhanbad City. Identification of pollution sources at study area has been performed by using PCA statistical methods. Air quality index (AQI) and air quality health index (AQHI) were calculated based on the concentration levels of PM10...
May 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28551741/soil-calcium-significantly-promotes-uptake-of-inorganic-arsenic-by-garland-chrysanthemum-chrysanthemuml-coronarium-fertilized-with-chicken-manure-bearing-roxarsone-and-its-metabolites
#14
Lixian Yao, Lianxi Huang, Cuihua Bai, Zhaohuan He, Changmin Zhou
Roxarsone (ROX), a widely used feed organoarsenic additive, occurs as itself and its metabolites in animal manure that is commonly land used as fertilizer. Soil property impacts arsenic (As) speciation and bioavailability. Fourteen soils across China were used to conduct culture experiments to investigate As uptake by garland chrysanthemum (ChrysanthemumL coronarium), with the soils fertilized with chicken manure bearing ROX and its metabolites. The results show As(III) was the sole As form in garland chrysanthemum shoots, and As(III) and As(V) occurred in roots...
May 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28551699/the-role-of-somatostatin-in-glp-1-induced-inhibition-of-glucagon-secretion-in-mice
#15
Anne Ørgaard, Jens J Holst
AIMS/HYPOTHESIS: Glucagon-like peptide-1 (GLP-1) receptor agonists are currently used for the treatment of type 2 diabetes. Their main mechanism of action is enhancement of glucose-induced insulin secretion (from increased beta cell glucose sensitivity) and inhibition of glucagon secretion. The latter has been demonstrated to account for about half of their blood glucose-lowering activity. Whereas the effect of GLP-1 on insulin secretion is clearly dependent on ambient glucose concentrations and has been described in detail, the mechanism responsible for the inhibitory effect of GLP-1 on glucagon secretion is heavily debated...
May 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/28551698/glucose-metabolism-during-rotational-shift-work-in-healthcare-workers
#16
Anu Sharma, Marcello C Laurenti, Chiara Dalla Man, Ron T Varghese, Claudio Cobelli, Robert A Rizza, Aleksey Matveyenko, Adrian Vella
AIMS/HYPOTHESIS: Shift-work is associated with circadian rhythm disruption and an increased risk of obesity and type 2 diabetes. We sought to determine the effect of rotational shift-work on glucose metabolism in humans. METHODS: We studied 12 otherwise healthy nurses performing rotational shift-work using a randomised crossover study design. On each occasion, participants underwent an isotope-labelled mixed meal test during a simulated day shift and a simulated night shift, enabling simultaneous measurement of glucose flux and beta cell function using the oral minimal model...
May 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/28551696/zinc-finger-e-box-binding-protein-2-zeb2-suppress-apoptosis-of-vascular-endothelial-cells-induced-by-high-glucose-through-mitogen-activated-protein-kinases-mapk-pathway-activation
#17
Lin-Jun Wang, Zi-Heng Wu, Xiang-Tao Zheng, Jian-Yun Long, Yang-Min Dong, Xin Fang
BACKGROUND Hyperglycemia has been confirmed to damage endothelial function of vascular and microvascular. The regulation of zinc finger E-box binding protein 2 (ZEB2) on vascular endothelial cells (VECs) is reported rarely. Our study investigates the role of ZEB2 on the apoptosis of VECs induced by high glucose through MAPK pathway. MATERIAL AND METHODS Downregulated and upregulated expression of ZEB2 in human umbilical vein endothelial cells (HUVECs) were performed by plasmids transfection. HUVECs are respectively treated with different concentrations of glucose (5...
May 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28551695/down-syndrome-increased-risk-of-dementia-and-lipid-disturbances
#18
Anna Kłosowska, Agnieszka Ćwiklińska, Agnieszka Kuchta, Agata Berlińska, Maciej Jankowski, Jolanta Wierzba
Down syndrome (DS) is the most common chromosomal aberration and genetically determined cause of intellectual disability. DS patients often present with some congenital defects and chronic diseases, including early onset dementia, which affects 70% of DS patients over 55 years of age and has a clinical presentation similar to Alzheimer disease (AD). The symptoms of DS originate from excessive genetic material within the "critical region" of the 21st chromosome. The "critical region" encompasses genes potentially associated with increase risk of dementia, e...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28551677/serum-levels-of-igf-1-and-igfbp-3-in-relation-to-clinical-and-pathobiological-aspects-of-head-and-neck-squamous-cell-carcinomas
#19
David Kalfert, Marie Ludvikova, Ondrej Topolcan, Petr Celakovsky, Radek Kucera, Jindra Windrichova, Jaroslav Ludvik, Katerina Skalova, Vlastimil Kulda, Martin Pesta, Jan Plzak
BACKGROUND/AIM: Head and neck squamous cell carcinoma (HNSCC) includes tumors of various anatomical sites sharing multifactorial etiopathogenesis and generally dismal response to conventional treatment. The objective of this study was to determine the clinical significance of serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in HNSCC. PATIENTS AND METHODS: A total of 46 patients, with histologically-confirmed diagnosis of HNSCC (21 oropharyngeal, 21 laryngeal, and 4 hypopharyngeal cancers) were enrolled in this study...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551657/circulating-antibodies-to-linear-peptide-antigens-derived-from-anxa1-and-foxp3-in-lung-cancer
#20
Weili Wang, Wen Zhong, Cairen Chen, Qingyong Meng, Jun Wei
BACKGROUND: Our previous studies revealed that concentrations of circulating antibodies to annexin A1 (ANXA1) and forkhead-box P3 (FOXP3) increased significantly in patients with non-small cell lung cancer (NSCLC). This study was thus undertaken to replicate our initial findings with different sample sets. PATIENTS AND METHODS: Antibodies were tested in 108 patients with NSCLC and 216 controls, who were divided into the discovery (49 vs. 108) and validation (60 vs...
June 2017: Anticancer Research
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