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https://www.readbyqxmd.com/read/29151276/microbial-growth-in-building-material-samples-and-occupants-health-in-severely-moisture-damaged-homes
#1
K Järvi, A Hyvärinen, M Täubel, A M Karvonen, M Turunen, K Jalkanen, R Patovirta, T Syrjänen, J Pirinen, H Salonen, A Nevalainen, J Pekkanen
There is no commonly approved approach to detect and quantify the health relevant microbial exposure in moisture damaged buildings. In 39 single-family homes with severe moisture damage, we studied whether concentrations of viable microbes in building material samples are associated with health among 71 adults and 68 children, assessed with symptoms questionnaires, exhaled NO and peak expiratory flow (PEF) variability. Symptoms were grouped into three scores: upper respiratory symptoms, lower respiratory symptoms and general symptoms...
November 19, 2017: Indoor Air
https://www.readbyqxmd.com/read/29151248/adiponectin-and-vitamin-d-binding-protein-are-independently-associated-at-birth-in-both-mothers-and-neonates
#2
Spyridon N Karras, Stergios Α Polyzos, Danforth A Newton, Carol L Wagner, Bruce W Hollis, Jody van den Ouweland, Erdinc Dursun, Duygu Gezen-Ak, Kalliopi Kotsa, Cedric Annweiler, Declan P Naughton
CONTEXT: Adult body fat is associated with birth anthropometry, suggesting a role for metabolic regulators including vitamin D and the adipokines-adiponectin and irisin-which have been reported to interact but, as yet, data remain controversial. OBJECTIVE: To study (i) the relationship between vitamin D, its binding protein (VDBP) and the adipokines, adiponectin, and irisin in mothers and neonates at birth and (ii) their effects on neonate anthropometric outcomes...
November 18, 2017: Endocrine
https://www.readbyqxmd.com/read/29151239/increased-serum-3-carboxy-4-methyl-5-propyl-2-furanpropanoic-acid-cmpf-levels-are-associated-with-glucose-metabolism-in-chinese-pregnant-women
#3
J Yi, H Jin, R Zhang, S Zhang, P Chen, X Yu, X Zhang
PURPOSE: Previous studies have found that 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) was associated with diabetes. This study aimed to investigate the relationship between abnormal increased CMPF levels and gestational diabetes mellitus (GDM). METHODS: We recruited 828 pregnant women, and all of them underwent an oral glucose tolerance test (OGTT). We screened out 141 GDM patients and 230 pregnant women with normal glucose tolerance as controls. The serum CMPF concentration in participants was measured, and the relationship between the serum CMPF concentration and various parameters and biochemical indices was analyzed...
November 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29151198/high-substance-use-and-hiv-risk-behavior-among-young-argentine-men-who-have-sex-with-men
#4
Iván C Balán, Timothy Frasca, María A Pando, Rubén O Marone, Victoria Barreda, Curtis Dolezal, Alex Carballo-Diéguez, María M Ávila
In the United States young men who have sex with men have higher rates of substance use, higher HIV incidence, and less frequent HIV testing than their heterosexual counterparts and older MSM. Less is known about comparable populations in Latin America. As part of an epidemiological study, MSM were recruited through Respondent Driven Sampling in the metropolitan area of Buenos Aires, Argentina and answered a computerized behavioral survey. From the total of 500 MSM enrolled, a sub-sample of 233 aged 18-25 was analyzed...
November 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29151191/silica-nanoparticle-exposure-inducing-granulosa-cell-apoptosis-and-follicular-atresia-in-female-balb-c-mice
#5
Jianhui Liu, Man Yang, Li Jing, Lihua Ren, Jialiu Wei, Jin Zhang, Feng Zhang, Junchao Duan, Xianqing Zhou, Zhiwei Sun
Given that the effects of ultrafine fractions (< 0.1 μm) on reproductive diseases are gaining attention, this study aimed to explore the influence of silica nanoparticle (SiNP)-induced female reproductive dysfunction. In this study, 80 female mice were randomly divided into four groups including a control group and three concentrations of SiNP groups (7, 21, 35 mg/kg). Mice were exposed to the vehicle control and silica nanoparticles by tracheal perfusion every 3 days a total of five times in 15 days...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29151189/the-environmental-pollutant-bde-209-regulates-no-cgmp-signaling-through-activation-of-nmda-receptors-in-neurons
#6
Jingsi Chen, Xiuying Li, Xiaomei Li, Dunjin Chen
The common flame retardant decabrominated diphenyl ether (BDE-209) is a persistent organic pollutant. Epidemiological studies have revealed that prenatal or postnatal exposure to BDE-209 can result in delayed cognitive development, and BDE-209 has been shown to be toxic to cultured neurons with maturation interference effects. However, its neurotoxic mechanism remains unclear. Nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling plays an important role in regulating neuronal maturation. We examined the influence of BDE-209 (100, 200, and 400 nM) on NO production and cGMP levels signaling in rodent neurons in vitro, with or without pretreatment N-methyl-D-aspartate (NMDA) receptor antagonism...
November 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29151188/dry-flue-gas-desulfurization-by-product-application-effects-on-plant-uptake-and-soil-storage-changes-in-a-managed-grassland
#7
Jason R Burgess-Conforti, Kristofor R Brye, David M Miller, Erik D Pollock, Lisa S Wood
Environmental regulations mandate that sulfur dioxide (SO2) be removed from the flue gases of coal-fired power plants, which results in the generation of flue gas desulfurization (FGD) by-products. These FGD by-products may be a viable soil amendment, but the large amounts of trace elements contained in FGD by-products are potentially concerning. The objective of this study was to evaluate the effects of land application of a high-Ca dry FGD (DFGD) by-product on trace elements in aboveground biomass and soil...
November 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29151187/spatial-distributions-of-hexachlorobutadiene-in-agricultural-soils-from-the-yangtze-river-delta-region-of-china
#8
Jianteng Sun, Lili Pan, Yu Zhan, Lizhong Zhu
Hexachlorobutadiene (HCBD) is one of the persistent organic pollutants (POPs) listed by the Stockholm Convention and poses potential risks to human health and ecosystems. To reveal the regional-scale pollution status of HCBD in agricultural soils from fast-developing areas, an extensive investigation was conducted in the core Yangtze River Delta (YRD), China. The detectable concentrations of HCBD in 241 soil samples ranged from 0.07 to 8.47 ng g(-1) dry weight, with an average value of 0.32 ng g(-1) and a detection rate of 59...
November 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29151186/biochar-effects-on-uptake-of-cadmium-and-lead-by-wheat-in-relation-to-annual-precipitation-a-3-year-field-study
#9
Fengfeng Sui, Jing Zuo, De Chen, Lianqing Li, Genxing Pan, David E Crowley
Biochar has been widely studied for its ability to reduce plant uptake of heavy metals by lowering metal bioavailabilities through adsorption and pH-driven fixation reactions. However, the long-term effect of biochar on heavy metal bioavailabilities in alkaline soils under natural redox condition is rarely studied. Here, we report a study examining the effects of biochar on bioavailability and partitioning of cadmium (Cd) and lead (Pb) among different soil fractions over 3 years in a field study with wheat (Triticum aestivum L...
November 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29151185/mercury-in-organs-of-pacific-walruses-odobenus-rosmarus-divergens-from-the-bering-sea
#10
Alexey M Trukhin, Mikhail V Simokon
The Pacific walrus (Odobenus rosmarus divergens) is still used as an important source of protein-rich food by indigenous peoples of Chukotka, Alaska, and other Arctic regions. Total mercury (THg) concentration was measured in eight internal organs of walruses. Samples were taken from 22 individuals (11 males and 11 females). Age of the animals ranged from 1 to 30 years. All the walruses were harvested by local hunters from the coastal waters off the Chukchi Peninsula (Russia) during the autumn of 2011. Total mercury concentration in the samples was determined by atomic absorption method...
November 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29151158/guidelines-to-reach-high-quality-purified-recombinant-proteins
#11
REVIEW
Carla Oliveira, Lucília Domingues
The final goal in recombinant protein production is to obtain high-quality pure protein samples. Indeed, the successful downstream application of a recombinant protein depends on its quality. Besides production, which is conditioned by the host, the quality of a recombinant protein product relies mainly on the purification procedure. Thus, the purification strategy must be carefully designed from the molecular level. On the other hand, the quality control of a protein sample must be performed to ensure its purity, homogeneity and structural conformity, in order to validate the recombinant production and purification process...
November 18, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29151140/effects-of-oxygen-availability-on-oxidative-stress-biomarkers-in-the-mediterranean-mussel-mytilus-galloprovincialis
#12
Alessia Giannetto, Maria Maisano, Tiziana Cappello, Sabrina Oliva, Vincenzo Parrino, Antonino Natalotto, Giuseppe De Marco, Salvatore Fasulo
In aquatic environments, hypoxia and oxygen-deficient areas are increasing worldwide. Transitions in oxygen levels can influence the production of reactive oxygen species (ROS), eventually leading to oxidative stress. The transcriptional response of oxidative stress biomarkers was evaluated by qPCR in gill tissue from Mytilus galloprovincialis experimentally subjected to 48-h air exposure followed by 48-h re-oxygenation, as compared to normoxic control mussels. Superoxide dismutases (CuZnsod and Mnsod), catalase (cat), and glutathione S-transferase (gst) were over-expressed early after 8-h air exposure and returned to normoxic levels during re-oxygenation...
November 18, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/29151137/blood-brain-barrier-transport-and-neuroprotective-potential-of-blackberry-digested-polyphenols-an-in-vitro-study
#13
Inês Figueira, Lucélia Tavares, Carolina Jardim, Inês Costa, Ana P Terrasso, Andreia F Almeida, Coen Govers, Jurriaan J Mes, Rui Gardner, Jörg D Becker, Gordon J McDougall, Derek Stewart, Augusto Filipe, Kwang S Kim, Dora Brites, Catarina Brito, M Alexandra Brito, Cláudia N Santos
PURPOSE: Epidemiological and intervention studies have attempted to link the health effects of a diet rich in fruits and vegetables with the consumption of polyphenols and their impact in neurodegenerative diseases. Studies have shown that polyphenols can cross the intestinal barrier and reach concentrations in the bloodstream able to exert effects in vivo. However, the effective uptake of polyphenols into the brain is still regarded with some reservations. Here we describe a combination of approaches to examine the putative transport of blackberry-digested polyphenols (BDP) across the blood-brain barrier (BBB) and ultimate evaluation of their neuroprotective effects...
November 18, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29151127/permeability-of-hair-to-cadmium-copper-and-lead-in-five-species-of-terrestrial-mammals-and-implications-in-biomonitoring
#14
A N Rendón-Lugo, P Santiago, I Puente-Lee, L León-Paniagua
The capacity of mammal hair to absorb toxic metals and its utility in biomonitoring has been broadly studied. Though these metal-binding properties has generally been attributed to the sulphur contained in cysteine, an amino acid that forms part of keratin, there are not many experimental studies that analyze the role of sulphur in the external deposition of potentially toxic metallic elements in order to better understand the potential of hair in biomonitoring and generate better tools for differentiating between internal and external deposition of contaminants...
November 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29151108/a-phenomenological-account-of-sensorimotor-difficulties-in-autism-intentionality-movement-and-proprioception
#15
Till D A Grohmann
During the last decades, the focus in autism research has been progressively extended. Today it offers a large amount of material on sensorimotor disturbances as well as perceptive-cognitive preferences of people with autism. However, there are more and more critical voices against an intellectualist perspective in the cognitive sciences. The "enactive approach" as well as a new "movement perspective" to autism challenge the view of autism as a mere "cognitive" disturbance. They criticize the conception of a cognizing subject which is only interested in the world in as much as she/he can extract knowledge and organize it rationally...
November 18, 2017: Psychopathology
https://www.readbyqxmd.com/read/29151081/association-between-standard-laboratory-and-functional-tests-of-coagulation-in-dilutional-coagulopathy-an-in-vitro-study
#16
L J Krzych, P F Czempik
Standard laboratory tests (SLTs) of coagulation are in common use in clinical practice. We aimed to determine the association between SLTs and functional tests of coagulation in blood samples diluted with balanced crystalloid and colloid solutions in an ex vivo setting. The study group comprised 32 healthy young male volunteers. Whole blood samples were diluted at a 4:1 ratio with balanced crystalloid (Plasmalyte®) and two balanced colloids, 6% hydroxyethyl starch 130/0.4 (Volulyte®) and succinylated gelatin (Geloplasma®)...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29151079/mechanisms-of-vasorelaxation-induced-by-total-flavonoids-of-euphorbia-humifusa-in-rat-aorta
#17
T T Wang, Z Q Zhou, S Wang, X W Ji, B Wu, L Y Sun, J F Wen, D G Kang, H S Lee, K W Cho, S N Jin
Euphorbia humifusa Willd. (EH), rich in flavonoids, has long been used for the treatment of bacillary dysentery and enteritis in China, and is known to have antioxidant, hypotensive and hypolipidemic properties. However, the vasorelaxant effect of total flavonoids of EH (TFEH) and action mechanisms are not clearly defined yet. The aim of the present study was to investigate the effects of TFEH on the vascular tension and its underlying mechanisms. Experiments were performed in rat thoracic aorta using the organ bath system...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29151078/therapeutic-effect-of-exogenous-ghrelin-in-the-healing-of-gingival-ulcers-is-mediated-by-the-release-of-endogenous-growth-hormone-and-insulin-like-growth-factor-1
#18
J Cieszkowski, Z Warzecha, P Ceranowicz, D Ceranowicz, B Kusnierz-Cabala, M Pedziwiatr, M Dembinski, T Ambrozy, T Kaczmarzyk, M Pihut, M Wieckiewicz, R Olszanecki, A Dembinski
Ghrelin, an acylated 28-amino acid polypeptide, was primary isolated from the stomach, and the stomach is a main source of circulating ghrelin. Ghrelin strongly and dose-dependently stimulates release of growth hormone from the anterior pituitary, as well as increases food intake and fat deposition. Previous studies showed that ghrelin exhibits protective and therapeutic effect in different parts of the gastrointestinal system, including the oral cavity. The aim of present study was to examine the role of growth hormone and insulin-like growth factor-1 (IGF-1) in the healing of gingival ulcers...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29151073/effect-of-the-different-doses-of-acrylamide-on-acetylocholinoesterase-activity-thiol-groups-malondialdehyde-concentrations-in-hypothalamus-and-selected-muscles-of-mice
#19
M Kopanska, J Czech, P Zagata, L Dobrek, P Thor, G Formicki
Acrylamide is a chemical compound that typically forms in starchy food products during high-temperature cooking, including frying, baking and roasting. Acrylamide is a known lethal neurotoxin. Its discovery in some cooked starchy foods in 2002 prompted concerns about the carcinogenicity of those foods. Little is known about acrylamide's influence on the peripheral nerves. In our research we measured acrylamide's influence on the acetylcholinesterase activity in hypothalamus, heart muscle, skeletal muscles of the thigh and smooth muscle of the small intestine (males, Swiss strain) in relation to the thiol groups and malondialdehyde concentration...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29151070/circadian-rhythms-of-melatonin-and-cortisol-in-manifest-huntington-s-disease-and-in-acute-cortical-ischemic-stroke
#20
A Adamczak-Ratajczak, J Kupsz, M Owecki, D Zielonka, A Sowinska, Z Checinska-Maciejewska, H Krauss, S Michalak, M Gibas-Dorna
Recent studies indicate disruptions to the circadian system in brain injury and neurodegeneration. The results, however, are often not consistent and limited by measurement of only one circadian marker and by infrequent sampling rates. In this study, we examined diurnal rhythmicity in different stages of Huntington (HD) disease and in patients with acute moderate ischemic stroke (AIS) outside the retinohypothalamic pathway by evaluating serum concentrations of melatonin and cortisol at twelve timepoints. All study participants were subjected to the same study protocol of 12-hour light/dark cycle and controlled room conditions...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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