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https://www.readbyqxmd.com/read/28239752/potential-and-limitations-of-cochrane-reviews-in-pediatric-cardiology-a-systematic-analysis
#1
Martin Poryo, Sara Khosrawikatoli, Hashim Abdul-Khaliq, Sascha Meyer
Evidence-based medicine has contributed substantially to the quality of medical care in pediatric and adult cardiology. However, our impression from the bedside is that a substantial number of Cochrane reviews generate inconclusive data that are of limited clinical benefit. We performed a systematic synopsis of Cochrane reviews published between 2001 and 2015 in the field of pediatric cardiology. Main outcome parameters were the number and percentage of conclusive, partly conclusive, and inconclusive reviews as well as their recommendations and their development over three a priori defined intervals...
February 27, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28239318/maternal-and-fetal-outcomes-in-pregnant-japanese-women-with-inflammatory-bowel-disease-our-experience-with-a-series-of-23-cases
#2
Naoki Minami, Minoru Matsuura, Yorimitsu Koshikawa, Satoshi Yamada, Yusuke Honzawa, Shuji Yamamoto, Hiroshi Nakase
BACKGROUND/AIMS: Our physicians work to expand the possibilities to treat female patients with inflammatory bowel disease (IBD) who wish to become pregnant. Although many drugs, including 5-aminosalicylate (5-ASA), corticosteroids, immunomodulators, and biologics, are used safely during pregnancy, few reports have described the therapeutic regimen throughout pregnancy and the management of patients who relapse during pregnancy precisely. The aim of this study was to assess the management of patients with IBD during pregnancy...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28238681/early-amplitude-integrated-electroencephalography-for-monitoring-neonates-at-high-risk-for-brain-injury
#3
Gabriel Fernando Todeschi Variane, Maurício Magalhães, Renato Gasperine, Heitor Castelo Branco Rodrigues Alves, Thiago Luiz Pereira Donoso Scoppetta, Rodrigo de Jesus Gonçalves Figueredo, Francisco Paulo Martins Rodrigues, Alexandre Netto, Marcelo Jenne Mimica, Clery Bernardi Gallacci
OBJECTIVE: This study aimed to correlate amplitude-integrated electroencephalography findings with early outcomes, measured by mortality and neuroimaging findings, in a prospective cohort of infants at high risk for brain injury in this center in Brazil. METHODS: This blinded prospective cohort study evaluated 23 preterm infants below 31 weeks of gestational age and 17 infants diagnosed with hypoxic-ischemic encephalopathy secondary to perinatal asphyxia, with gestational age greater than 36 weeks, monitored with amplitude-integrated electroencephalography in a public tertiary center from February 2014 to January 2015...
February 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28238479/differential-effects-of-the-single-family-room-neonatal-intensive-care-unit-on-18-to-24-month-bayley-scores-of-preterm-infants
#4
Betty Vohr, Elisabeth McGowan, Leslie McKinley, Richard Tucker, Lenore Keszler, Barbara Alksninis
OBJECTIVES: To determine the effects of human milk and social/environmental disparities on developmental outcomes of infants born preterm cared for in a single-family room (SFR) neonatal intensive care unit (NICU). STUDY DESIGN: Outcomes were compared between infants weighing ≤1250 g cared for in an open-bay NICU (1/2007-8/2009) (n = 394) and an SFR NICU (1/2010-12/2011) (n = 297). Human milk provision at 1 week, 4 weeks and discharge, and 4 week volume (mL/kg/day) were analyzed...
February 24, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28238222/calcium-and-phosphorus-supplementation-of-human-milk-for-preterm-infants
#5
REVIEW
Jane E Harding, Jess Wilson, Julie Brown
BACKGROUND: Preterm infants are born with low skeletal stores of calcium and phosphorus. Preterm human milk provides insufficient calcium and phosphorus to meet the estimated needs of preterm infants for adequate growth. Supplementation of human milk with calcium and phosphorus may improve growth and development of preterm infants. OBJECTIVES: To determine whether addition of calcium and phosphorus supplements to human milk leads to improved growth and bone metabolism of preterm infants without significant adverse effects...
February 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28237510/retrospective-evaluation-of-a-national-guideline-to-prevent-neonatal-hypoglycemia
#6
Annett Helleskov Rasmussen, Sonja Wehberg, Jesper Fenger-Groen, Henrik Thybo Christesen
BACKGROUND: Hypoglycemia is common in neonates and may cause adverse neurological outcomes. Guidelines should aim to prevent repeated hypoglycemic episodes in risk groups, but they are not usually stratified according to the severity of hypoglycemia risk, which may lead to inappropriate and redundant interventions. We evaluated the effect of a national prevention guideline stratified according to mild, moderate, and severe risks of hypoglycemia. METHODS: From national registers, a population cohort of 22,725 neonates was identified retrospectively before and after implementation of a national guideline...
January 24, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28237375/maternal-mental-health-and-neonatal-intensive-care-unit-discharge-readiness-in-mothers-of-preterm-infants
#7
Elisabeth C McGowan, Nan Du, Katheleen Hawes, Richard Tucker, Melissa O'Donnell, Betty Vohr
OBJECTIVE: To evaluate associations between maternal mental health disorders (MHDs) and discharge readiness for mothers of infants born preterm (<37 weeks). We hypothesized that mothers with a history of MHDs would report decreased perceptions of neonatal intensive care unit (NICU) discharge readiness compared with mothers without a history. STUDY DESIGN: Mothers of infants born preterm in the NICU >5 days between 2012 and 2015 and participating in a transition home program completed a discharge readiness questionnaire measuring perceptions of staff support, infant well-being (medical stability), maternal well-being (emotional readiness/competency), and maternal comfort (worry about infant)...
February 22, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28235686/the-effects-of-massage-therapy-in-hospitalized-preterm-neonates-a-systematic-review
#8
REVIEW
María José Álvarez, Daniel Fernández, Juan Gómez-Salgado, Dolores Rodríguez-González, María Rosón, Santiago Lapeña
OBJECTIVE: The aim of this study was to perform a systematic review to identify, evaluate and summarise studies on the administration of therapeutic massage to preterm neonates during their stay in the NICU, and to assess their methodological quality. DESIGN: systematic review following PRISMA statements guidelines. DATA SOURCES: A comprehensive search was performed including relevant articles between January 2004 and December 2013, using the following electronic databases: Medline, PEDro, Web of Science and Scopus...
February 14, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28231658/-relationship-between-reproductive-history-and-preterm-births-in-the-last-pregnancy-in-shaanxi-province
#9
B W Qin, J Ying, Q Lei, P F Qu, F L Lei, J M Li, H Yan
Objective: To analyze the incidence of preterm delivery among single live neonates and the association between maternal reproductive history and preterm birth. Methods: A questionnaire survey was conducted on reproductive history among women at childbearing age who were selected through multi-stage stratified random sampling method in Shaanxi, during 2010-2013. Samples would include women at childbearing age and in pregnancy or having had definite pregnancy outcomes. Results: A total of 29 608 women at childbearing age with their infants, were studied...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231603/the-effect-of-birth-order-on-neonatal-morbidity-and-mortality-in-very-preterm-twins
#10
Elad Mei-Dan, Jyotsna Shah, Shoo Lee, Prakesh S Shah, Kellie E Murphy
Objective  This retrospective cohort study examined the effect of birth order on neonatal morbidity and mortality in very preterm twins. Study Design Using 2005 to 2012 data from the Canadian Neonatal Network, very preterm twins born between 24 (0/7) and 32 (6/7) weeks of gestation were included. Odds of morbidity and mortality of second-born cotwins compared with first-born cotwins were examined by matched-pair analysis. Outcomes were neonatal death, severe brain injury (intraventricular hemorrhage grade 3 or 4 or persistent periventricular echogenicity), bronchopulmonary dysplasia, severe retinopathy of prematurity (ROP) (> stage 2), necrotizing enterocolitis (≥ stage 2), and respiratory distress syndrome (RDS)...
February 23, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28230835/sudden-versus-gradual-pressure-wean-from-nasal-cpap-in-preterm-infants-a-randomized-controlled-trial
#11
S Amatya, M Macomber, A Bhutada, D Rastogi, S Rastogi
OBJECTIVE: In preterm infants, nasal continuous positive airway pressure (NCPAP) is widely used for treatment of respiratory distress syndrome. However, the strategies for successfully weaning infants off NCPAP are still not well defined and there remains considerable variation between the methods. The objective of this study is to determine whether gradual weaning of NCPAP pressure is more successful than sudden weaning off NCPAP to room air. STUDY DESIGN: A randomized controlled trial was conducted in a level 3 neonatal intensive care unit on 70 preterm neonates who were born between 26 and 32 weeks gestation and required NCPAP for at least 48 h...
February 23, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28229835/-neurodevelopmental-outcomes-of-very-preterm-or-very-low-birth-weigth-infants-comparison-of-monochorionic-and-dichorionic-twins-with-singletons
#12
Adelaide Taborda, Guiomar Oliveira
INTRODUCTION: Twins are associated with a delayed development and cerebral palsy. The purpose of this work was to compare the neurologic morbidity in very preterm or very low birth weight dichorionic and monochorionic twins with singletons. MATERIAL AND METHODS: We conducted a retrospective cohort study of livebirths lowest through 32 weeks of gestation or very low weight infants admitted to Neonatal Intensive Care Unit of a level III hospital, between 2006 and 2010...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229280/posterior-urethral-valve-in-fetuses-evidence-for-the-role-of-inflammatory-molecules
#13
Érica Leandro Marciano Vieira, Natalia Pessoa Rocha, Fernando Macedo Bastos, Kátia Daniela da Silveira, Alamanda K Pereira, Eduardo Araújo Oliveira, Débora Marques de Miranda, Ana Cristina Simões E Silva
BACKGROUND: The aim of this cross-sectional study was to investigate inflammatory biomarkers in urine samples of 24 fetuses with posterior urethral valve (PUV) collected at 22 ± 4 weeks of gestation and to compare the findings with measurements in urine samples of 22 male healthy preterm neonates at 23 ± 4 weeks (control group). METHODS: Inflammatory biomarkers in urine were measured using a cytometric bead array [interleukin (IL)-2, IL-4, IL-6, IL-10, interferon (IFN)-γ, soluable tumor necrosis factor receptor (TNFR) 1, sTNFR2, monocyte chemoattractant protein-1/chemokine ligand 2 (MCP-1/CCL2), eotaxin/CCL11 and interferon gamma-induced protein/10/C-X-C motif chemokine 10 (IP-10/CXCL10)] and ELISA assays [TNF, IL-8/CXCL8 and transforming growth factor-beta (TGF-β)]...
February 22, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28228969/prevention-and-treatment-of-neonatal-nosocomial-infections
#14
REVIEW
Jayashree Ramasethu
Nosocomial or hospital acquired infections threaten the survival and neurodevelopmental outcomes of infants admitted to the neonatal intensive care unit, and increase cost of care. Premature infants are particularly vulnerable since they often undergo invasive procedures and are dependent on central catheters to deliver nutrition and on ventilators for respiratory support. Prevention of nosocomial infection is a critical patient safety imperative, and invariably requires a multidisciplinary approach. There are no short cuts...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28228752/intestinal-microbiota-and-weight-gain-in-preterm-neonates
#15
Silvia Arboleya, Pablo Martinez-Camblor, Gonzalo Solís, Marta Suárez, Nuria Fernández, Clara G de Los Reyes-Gavilán, Miguel Gueimonde
The involvement of the gut microbiota on weight-gain and its relationship with childhood undernutrition and growth has been reported. Thus, the gut microbiota constitutes a potential therapeutic target for preventing growth impairment. However, our knowledge in this area is limited. In this study we aimed at evaluating the relationship among early microbiota, growth, and development in preterm infants. To this end we assessed the levels of specific microorganisms by qPCR, and those of short chain fatty acids by mean of gas-chromatography, in feces from 63 preterm newborns and determined their weight-gain during the first months...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28228499/neonatal-morbidity-and-1-year-survival-of-extremely-preterm-infants
#16
Hans Jorgen Stensvold, Claus Klingenberg, Ragnhild Stoen, Dag Moster, Kristin Braekke, Hans Jorgen Guthe, Henriette Astrup, Siren Rettedal, Morten Gronn, Arild E Ronnestad
OBJECTIVE: To determine 1-year survival and major neonatal morbidities (intracranial hemorrhage grade >2, cystic periventricular leukomalacia, retinopathy of prematurity grade >2, necrotizing enterocolitis, severe bronchopulmonary dysplasia) among extremely preterm infants in Norway in 2013-2014, and to compare the results to the first Norwegian Extreme Prematurity Study 1999-2000 and similar contemporary European population-based studies. METHODS: Population-based study of all infants born at 22 through 26 weeks' gestation in Norway in 2013-2014...
February 22, 2017: Pediatrics
https://www.readbyqxmd.com/read/28225489/immunoregulation-effects-of-different-%C3%AE-%C3%AE-t-cells-and-toll-like-receptor-signaling-pathways-in-neonatal-necrotizing-enterocolitis
#17
Lei Hui, Yi Dai, Zhi Guo, Jiahui Zhang, Fang Zheng, Xiangli Bian, Zhimin Wu, Qin Jiang, Miaomiao Guo, Ke Ma, Jinping Zhang
The aim of the study was to observe cytokine and T-cell-related toll-like-receptor (TLR) changes in intestinal samples of neonatal necrotizing enterocolitis patients.Four necrotic bowels were collected from neonatal NEC patients with gestational ages of 28 to 29 weeks in our hospital, whereas 4 neonatal patients who underwent intestinal atresia surgery served as the controls. Intestinal flora was examined and IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ, and IL-17 expressions in resected intestine samples, as well as in isolated gamma delta T (γδT) cells, were analyzed immunohistochemically and via quantitative RT-PCR...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28224678/microbiome-autoimmunity-allergy-and-helminth-infection-the-importance-of-the-pregnancy-period
#18
Xian Chen, Su Liu, Qiao Tan, Yehuda Shoenfeld, Yong Zeng
Pregnancy is a special physical period in reproductive age women, which has a beneficial influence on the course of certain autoimmune diseases. It has been recently suggested that the microbiome undergoes profound changes during pregnancy that are associated with host physiological and immunological adaptations. The maternal microbiome remodeling during pregnancy is an active response of the mother, possibly to alter immune system status and to facilitate metabolic and immunological adaptations, which are needed for a successful pregnancy...
February 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28224332/association-of-single-nucleotide-polymorphisms-of-il23r-and-il17-with-necrotizing-enterocolitis-in-premature-infants
#19
Jiayi Tian, Yanjun Liu, Yanfang Jiang, Haohan Zhou, Tong Zhu, Xiaoqi Zhao, Liping Peng, Chaoying Yan
Necrotizing enterocolitis (NEC) is a severe gastrointestinal inflammatory disease in neonates, particularly in preterm infants. The interleukin (IL) 23/IL17 axis has been shown to play an important role in the gastrointestinal inflammation. However, the association of gene polymorphisms in the IL23/IL17 axis and the development of NEC remains unknown. In this study, we aimed to explore a possible genetic role of IL23R and IL17 in the development of NEC. We identified single nucleotide polymorphisms (SNPs) in IL23R (rs10889677), IL17A (rs2275913), and IL17F (rs763780) by polymerase chain reaction and Sanger sequencing...
February 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28224121/immunological-defects-in-neonatal-sepsis-and-potential-therapeutic-approaches
#20
REVIEW
Steven L Raymond, Julie A Stortz, Juan C Mira, Shawn D Larson, James L Wynn, Lyle L Moldawer
Despite advances in critical care medicine, neonatal sepsis remains a major cause of morbidity and mortality worldwide, with the greatest risk affecting very low birth weight, preterm neonates. The presentation of neonatal sepsis varies markedly from its presentation in adults, and there is no clear consensus definition of neonatal sepsis. Previous work has demonstrated that when neonates become septic, death can occur rapidly over a matter of hours or days and is generally associated with inflammation, organ injury, and respiratory failure...
2017: Frontiers in Pediatrics
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