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https://www.readbyqxmd.com/read/28931102/-areas-and-challenges-of-oncopsychological-rehabilitation
#1
Péter Kovács, Zsuzsa Koncz, Julianna Peti, Anna Gõdény, Dóra Horváth, Csilla Gerlinger, Katalin Lacsán, Petra Molnár, Ágnes Riskó
Patients with cancer present a number of different difficulties that adversely affect their health care and recovery (e.g. poor communication with physicians, lack of knowledge about their illness and its management, financial problems). Furthermore, mental health problems, such as distress, depression and anxiety, are common amongst patients with cancer. These mental health problems are additional contributors to functional impairment in carrying out family, work, and other social roles, poor adherence to medical treatments, and adverse medical outcomes...
September 20, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28931098/-differential-diagnosis-and-treatment-of-nausea-and-vomiting-associated-with-cancer-or-its-treatment
#2
Csaba Simkó
Nausea and vomiting are frequent and fearful issues both of cancer itself and its treatment, resulting in reduced quality of life, hospitalization and unnecessary medical investigations. Unconventionally, the author discusses the treatment-related and non-treatment-related complaints together, so as to give an integrated approach to this problem. Different types of nausea/vomiting and important causes are explained by discussion of the pathophysiology and clinical symptoms. Different classes of antiemetics are detailed, emphasizing the evolving role of olanzapine in the treatment of both the acute and delayed type of chemotherapy-induced nausea/vomiting...
September 20, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28931096/-nutrition-therapy-of-cancer-patients
#3
József Lövey
The majority of cancer patients becomes malnourished during the course of their disease. Malnutrition deteriorates the efficiency of all kinds of oncologic interventions. As a consequence of it, treatment-related toxicity increases, hospital stay is lengthened, chances of cure and survival as well as the quality of life of the patients worsen. Nutritional status therefore influences all aspects of outcome of oncology care. In spite of this the use of nutritional therapy varies across health care providers but its application is far from being sufficient during active oncology interventions as well as rehabilitation and supportive care...
September 20, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28931045/effect-of-extracytoplasmic-function-sigma-factors-on-autoaggregation-hemagglutination-and-cell-surface-properties-of-porphyromonas-gingivalis
#4
Kazutaka Fujise, Yuichiro Kikuchi, Eitoyo Kokubu, Kazuko Okamoto-Shibayama, Kazuyuki Ishihara
Porphyromonas gingivalis is a bacterium frequently isolated from chronic periodontal lesions and is involved in the development of chronic periodontitis. To colonize the gingival crevice, P. gingivalis has to adapt to environmental stresses. Microbial gene expression is regulated by transcription factors such as those in two-component systems and extracytoplasmic function (ECF) sigma factors. ECF sigma factors are involved in the regulation of environmental stress response genes; however, the roles of individual ECF sigma factors are largely unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28931004/the-logic-of-the-floral-transition-reverse-engineering-the-switch-controlling-the-identity-of-lateral-organs
#5
Jean-Louis Dinh, Etienne Farcot, Charlie Hodgman
Much laboratory work has been carried out to determine the gene regulatory network (GRN) that results in plant cells becoming flowers instead of leaves. However, this also involves the spatial distribution of different cell types, and poses the question of whether alternative networks could produce the same set of observed results. This issue has been addressed here through a survey of the published intercellular distribution of expressed regulatory genes and techniques both developed and applied to Boolean network models...
September 20, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28930921/sham-opioids-relieve-multidimensional-aspects-of-chronic-back-pain
#6
Luana Colloca
No abstract text is available yet for this article.
October 2017: Pain
https://www.readbyqxmd.com/read/28930919/2017-military-supplement-mini-review-perfluorocarbons-oxygen-transport-and-microcirculation-in-low-flow-states-in-vivo-and-in-vitro-studies
#7
Ivo P Torres Filho
The in vivo study of microvascular oxygen transport requires accurate and challenging measurements of several mass transfer parameters. Although recommended, blood flow and oxygenation are typically not measured in many studies where treatments for ischemia are tested. Therefore, the aim of this communication is to briefly review cardinal aspects of oxygen transport, and the effects of perfluorocarbon treatment on blood flow and oxygenation based mostly on studies performed in our laboratory. Since physiologically relevant events in oxygen transport take place at the microvascular level, we implemented the phosphorescence quenching technique coupled with non-invasive intravital videomicroscopy for quantitative evaluation of these events in vivo...
September 19, 2017: Shock
https://www.readbyqxmd.com/read/28930888/what-matters-most-to-whom-racial-ethnic-and-language-differences-in-the-health-care-experiences-most-important-to-patients
#8
Rebecca L Collins, Ann Haas, Amelia M Haviland, Marc N Elliott
BACKGROUND: Some aspects of patient experience are more strongly related to overall ratings of care than others, reflecting their importance to patients. However, little is known about whether the importance of different aspects of this experience differs across subgroups. OBJECTIVES: To determine whether the aspects of health care most important to patients differ according to patient race, ethnicity, and language preference. RESEARCH DESIGN: In response to the 2013 Medicare Consumer Assessment of Health Plans Study (CAHPS) survey, patients rated their overall health care and completed items measuring five patient experience domains...
September 19, 2017: Medical Care
https://www.readbyqxmd.com/read/28930825/acinar-cell-carcinoma-of-the-pancreas-presenting-as-diffuse-pancreatic-enlargement-two-case-reports-and-literature-review
#9
Yaping Luo, Guilan Hu, Yanru Ma, Ning Guo, Fang Li
RATIONALE: Pancreatic acinar cell carcinoma (ACC) is a rare malignant tumor of exocrine pancreas. It is typically a well-marginated large solid mass arising in a certain aspect of the pancreas. Diffuse involvement of ACC in the pancreas is very rare, and may simulate pancreatitis in radiological findings. We report 2 cases of ACC presenting as diffuse enlargement of the pancreas due to tumor involvement without formation of a distinct mass. PATIENT CONCERNS: The patients consisted of a 41-year-old man with weight loss and a 77-year-old man who was asymptomatic...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930704/holding-ashley-x-bestowing-identity-through-caregiving-in-profound-intellectual-disability
#10
Lisa Freitag, Joan Liaschenko
The controversy over the so-called Ashley Treatment (AT), a series of medical procedures that inhibited both growth and sexual development in the body of a profoundly intellectually impaired girl, usually centers either on Ashley's rights, including a right to an intact, unaltered body, or on Ashley's parents' rights to make decisions for her. The claim made by her parents, that the procedure would improve their ability to care for her, is often dismissed as inappropriate or, at best, irrelevant. We argue, however, that caregiving is a central issue in the controversy, as Ashley's need for caregiving is a defining characteristic of her life...
2017: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/28930675/dynamic-rearrangement-of-cell-states-detected-by-systematic-screening-of-sequential-anticancer-treatments
#11
Simon Koplev, James Longden, Jesper Ferkinghoff-Borg, Mathias Blicher Bjerregård, Thomas R Cox, Janine T Erler, Jesper T Pedersen, Franziska Voellmy, Morten O A Sommer, Rune Linding
Signaling networks are nonlinear and complex, involving a large ensemble of dynamic interaction states that fluctuate in space and time. However, therapeutic strategies, such as combination chemotherapy, rarely consider the timing of drug perturbations. If we are to advance drug discovery for complex diseases, it will be essential to develop methods capable of identifying dynamic cellular responses to clinically relevant perturbations. Here, we present a Bayesian dose-response framework and the screening of an oncological drug matrix, comprising 10,000 drug combinations in melanoma and pancreatic cancer cell lines, from which we predict sequentially effective drug combinations...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28930668/aspects-of-sexual-precocity-and-morphometry-of-uterus-placenta-and-embryos-fetuses-in-piau-breed-and-commercial-line-gilts
#12
José Carlos Montes, Jurandy Mauro Penitente-Filho, Simone Eliza Facioni Guimarães, Paulo Sávio Lopes, Breno Soares Camilo, Hugo Hideki Shiomi, Daniel Araújo Lima, Rogério Oliveira Pinho, Jhonata Vieira Tavares do Nascimento Pereira, Denise Silva Okano, Karine Assis Costa, José Domingos Guimarães
In view of the importance of the genetic material of local breeds in the swine industry and the lack of information about reproductive performance of Piau females, two experiments were conducted to evaluate puberty and sexual maturity as well as the morphometry of embryos/fetuses, placenta and uterus during the first 90 days of gestation in Piau breed and Commercial line gilts. In experiment I, 37 Piau and 25 commercial line gilts were used. From the 120 days of age, detection of estrus was performed using mature boars from the first to third estrus of each gilt...
September 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/28930633/controlled-orientation-of-droplets-in-ellipsoid-filled-polymeric-emulsions-by-particle-parameters-and-flow-conditions
#13
Chaoying Mao, Yajiang Huang, Junlong Yang, Miqiu Kong, Yuan Wang, Qi Yang, Guangxian Li
The effect of particle parameters (aspect ratio, AR, and concentration) and flow conditions (gap spacing and shear rate) on droplet orientation deformation behavior in polystyrene (PS) particle-filled binary polymeric emulsions is investigated by using rheo-optical technique and confocal microscopy. Interesting vorticity orientation behavior is achieved by tailoring experimental conditions to gain rigid anisotropic droplets during slow confined shear flow. PS ellipsoids with high AR are found to reside both at the fluid interface in a monolayer side-on state and inside droplets, leading to the formation of rigid anisotropic droplets due to interfacial/bulk jamming effect at appropriate particle concentrations...
September 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28930594/lipid-metabolism-and-transport-define-longevity-of-the-yeast-saccharomyces-cerevisiae
#14
Darya Mitrofanova, Pamela Dakik, Melissa McAuley, Younes Medkour, Karamat Mohammad, Vladimir I Titorenko
Emergent evidence indicates that certain aspects of lipid synthesis, degradation and interorganellar transport play essential roles in modulating the pace of cellular aging in the budding yeast Saccharomyces cerevisiae. The molecular mechanisms underlying the vital roles of lipid metabolism and transport in defining yeast longevity have begun to emerge. The scope of this review is to critically analyze recent progress in understanding such mechanisms.
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930591/lipoprotein-a-and-cardiovascular-disease-current-state-and-future-directions-for-an-enigmatic-lipoprotein
#15
Anum Saeed, Salim S Virani
Lipoprotein (a) (Lp (a)) is a complex polymorphic lipoprotein. Although structurally similar to low-density lipoprotein, Lp(a) has a glycoprotein, apolipoprotein(a) (apo(a)), attached to the apolipoprotein B-100 component. Several unique properties of Lp(a) can be attributed to the presence of apo(a). Several decades of research has improved our understanding of the structure, biochemistry, and pathophysiology of Lp(a) associated diseases. Genetic, epidemiological, and translational data indicate that elevated Lp(a) levels are likely in the causal pathway for atherosclerotic cardiovascular diseases as well as calcification of the aortic valves...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930585/leishmaniasis-treatment-update-of-possibilities-for-drug-repurposing
#16
Valter Viana Andrade-Neto, Edezio Ferreira Cunha-Junior, Viviane Dos Santos Faioes, Thais Pereira Martins, Raphaela Lopes Silva, Leonor Laura Leon, Eduardo Caio Torres-Santos
The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania  parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930572/immune-response-to-systemic-inflammation-in-the-intestinal-microcirculation
#17
Taylor Thorburn, Maral Aali, Christian Lehmann
Systemic inflammation is characterized by acute or chronic dysregulation of the host immune response. The intestine plays an important role in systemic inflammation. Disturbances in the intestinal microcirculation due to infiltration of immune cells during systemic inflammation can increase bacterial translocation from the gut to the circulation and aggravate the pathological condition. Therefore, the intestinal microcirculation is relevant with respect to two aspects - as pathophysiological trigger and therapeutic target in systemic inflammation...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930555/the-forgotten-modified-lipoprotein-subspecies
#18
Ahmed Bakillah, Mohamed Zaiou
Insights from preclinical and clinical studies have attempted to highlight the importance of modified lipoprotein particles in the pathogenesis of cardiovascular diseases (CVD). However, evidence is not conclusive. Since there is a relative dearth of clinical research in collecting useful information from traditional advanced lipoproteins testing, this present editorial introduces the aim of a special issue on modified lipoproteins as potential biomarkers for CVD. This issue aims at gathering a selection of insightful articles that address major challenges related to potential clinical use of modified lipoproteins as new CVD biomarkers...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930451/a-biomimetic-stress-sensitive-hydrogel-controlled-by-dna-nanoswitches
#19
Swapneel R Deshpande, Roel Hammink, Frank H T Nelissen, Alan E Rowan, Hans A Heus
One of the most intriguing and important aspects of biological supramolecular materials is its ability to adapt macroscopic properties in response to environmental cues for controlling cellular processes. Recently, bulk matrix stiffness, in particular stress sensitivity, has been established as a key mechanical cue in cellular function and development. However, stress-stiffening capacity and the ability to control and exploit this key characteristic is relatively new to the field of biomimetic materials. In this work, DNA-responsive hydrogels, composed of semiflexible PIC polymers equipped with DNA cross-linkers, were engineered to create mimics of natural biopolymer networks that capture these essential elastic properties and can be controlled by external stimuli...
September 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28930428/ion-transport-in-confined-geometries-below-the-nanoscale-access-resistance-dominates-protein-channel-conductance-in-diluted-solutions
#20
Antonio Alcaraz, M Lidón López, María Queralt-Martín, Vicente M Aguilella
Synthetic nanopores and mesoscopic protein channels have common traits like the importance of electrostatic interactions between the permeating ions and the nanochannel. Ion transport at the nanoscale occurs under confinement conditions so that the usual assumptions made in microfluidics are challenged, among others, by interfacial effects such as access resistance (AR). Here we show that a sound interpretation of electrophysiological measurements in terms of channel ion selective properties requires the consideration of interfacial effects, up to the point that they dominate protein channel conductance in diluted solutions...
September 20, 2017: ACS Nano
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