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https://www.readbyqxmd.com/read/28655206/deficient-emotion-processing-is-associated-with-everyday-functioning-capacity-in-hiv-associated-neurocognitive-disorder
#1
Jonathan M Grabyan, Erin E Morgan, Marizela V Cameron, Javier Villalobos, Igor Grant, Steven Paul Woods
Objective: Emotion processing has received little research focus in HIV, but emerging evidence suggests that abilities such as facial affect discrimination may be features of HIV-associated neurocognitive disorder (HAND). The present study hypothesized that individuals with HAND would evidence an emotion processing deficit relative to cognitively unimpaired individuals with HIV and seronegative comparison participants on a task assessing these abilities. Moreover, it was expected that this deficit would be significantly associated with social aspects of everyday functioning...
June 26, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28655166/communication-in-multiple-sclerosis-pragmatic-deficit-and-its-relation-with-cognition-and-social-cognition
#2
Antonio Carotenuto, Giorgio Arcara, Giuseppe Orefice, Ilaria Cerillo, Valentina Giannino, Mario Rasulo, Rosa Iodice, Valentina Bambini
Objective: Cognitive functions have been largely investigated in multiple sclerosis. Less attention has been paid to social communication abilities, despite their presumptive affect on quality of life. We run the first comprehensive assessment of pragmatic skills in multiple sclerosis, evaluating also the relationship between pragmatics and other cognitive domains. Methods: Forty-two multiple sclerosis patients and 42 controls were tested for pragmatic abilities, neuro-cognition, social cognition, depression, and fatigue...
June 26, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28655091/-outcomes-of-lenalidomide-based-treatment-for-57-patients-of-relapsed-or-refractory-multiple-myeloma
#3
S H Deng, Y Xu, W W Sui, G An, X H Mao, Z J Li, D H Zou, L G Qiu
Objective: To investigate the clinical efficacy and safety of lenalidomide (Revlimid, R) -based chemotherapy in the treatment of relapsed/refractory multiple myeloma (MM) patients. Methods: 57 consecutively relapsed/refractory MM patients were retrospectively analyzed from June 2013 to February 2016. All the patients received lenalidomide-based chemotherapy. Results: ① 60.4% patients had international staging system (ISS) stage Ⅲ, 37.9% patients had revised international staging system (R-ISS) stage Ⅲ, and 53...
June 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28655038/kinematic-analysis-of-speech-sound-sequencing-errors-induced-by-delayed-auditory-feedback
#4
Gabriel J Cler, Jackson C Lee, Talia Mittelman, Cara E Stepp, Jason W Bohland
Purpose: Delayed auditory feedback (DAF) causes speakers to become disfluent and make phonological errors. Methods for assessing the kinematics of speech errors are lacking, with most DAF studies relying on auditory perceptual analyses, which may be problematic, as errors judged to be categorical may actually represent blends of sounds or articulatory errors. Method: Eight typical speakers produced nonsense syllable sequences under normal and DAF (200 ms). Lip and tongue kinematics were captured with electromagnetic articulography...
June 22, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28654945/quantification-and-systematic-characterization-of-stuttering-like-disfluencies-in-acquired-apraxia-of-speech
#5
Dallin J Bailey, Michael Blomgren, Catharine DeLong, Kiera Berggren, Julie L Wambaugh
Purpose: The purpose of this article is to quantify and describe stuttering-like disfluencies in speakers with acquired apraxia of speech (AOS), utilizing the Lidcombe Behavioural Data Language (LBDL). Additional purposes include measuring test-retest reliability and examining the effect of speech sample type on disfluency rates. Method: Two types of speech samples were elicited from 20 persons with AOS and aphasia: repetition of mono- and multisyllabic words from a protocol for assessing AOS (Duffy, 2013), and connected speech tasks (Nicholas & Brookshire, 1993)...
June 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28654939/speech-versus-speaking-the-experiences-of-people-with-parkinson-s-disease-and-implications-for-intervention
#6
Kathryn Yorkston, Carolyn Baylor, Deanna Britton
Purpose: In this project, we explore the experiences of people who report speech changes associated with Parkinson's disease as they describe taking part in everyday communication situations and report impressions related to speech treatment. Method: Twenty-four community-dwelling adults with Parkinson's disease took part in face-to-face, semistructured interviews. Qualitative research methods were used to code and develop themes related to the interviews. Results: Two major themes emerged...
June 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28654743/territorial-differences-in-years-of-life-lost-due-to-premature-mortality-in-inhabitants-of-poland
#7
Małgorzata Pikala, Monika Burzyńska, Irena Maniecka-Bryła
INTRODUCTION: Reduction of social and territorial differences with regards to health of a population is one of the most crucial global problems of public health. An analysis of years of life lost focuses on social and economic aspects of premature mortality. AIM: The aim of the study is to analyze territorial differences in years of life lost due to premature mortality in inhabitants of various regions of Polan d, according to the most important causes of death, with consideration given to classification categories of ICD-10...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/28654703/development-of-a-forecasting-model-for-brucellosis-spreading-in-the-italian-cattle-trade-network-aimed-to-prioritise-the-field-interventions
#8
L Savini, L Candeloro, A Conte, F De Massis, A Giovannini
Brucellosis caused by Brucella abortus is an important zoonosis that constitutes a serious hazard to public health. Prevention of human brucellosis depends on the control of the disease in animals. Livestock movement data represent a valuable source of information to understand the pattern of contacts between holdings, which may determine the inter-herds and intra-herd spread of the disease. The manuscript addresses the use of computational epidemic models rooted in the knowledge of cattle trade network to assess the probabilities of brucellosis spread and to design control strategies...
2017: PloS One
https://www.readbyqxmd.com/read/28654610/what-s-new-in-syndromic-craniosynostosis-surgery
#9
Jesse A Taylor, Scott P Bartlett
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand the role of prenatal screening and counseling of parents of unborn children with syndromic craniosynostosis. 2. Recognize the genetic abnormalities, craniofacial phenotype, associated anomalies, and challenges associated with each of the five major forms of syndromic craniosynostosis. 3. Identify the pros and cons associated with timing and types of cranial vault remodeling techniques in this patient population...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654473/regenerative-rehabilitation-combining-stem-cell-therapies-and-activity-dependent-stimulation
#10
Chet T Moritz, Fabrisia Ambrosio
The number of clinical trials in regenerative medicine is burgeoning, and stem cell/tissue engineering technologies hold the possibility of becoming the standard of care for a multitude of diseases and injuries. Advances in regenerative biology reveal novel molecular and cellular targets, with potential to optimize tissue healing and functional recovery, thereby refining rehabilitation clinical practice. The purpose of this review is to (1) highlight the potential for synergy between the fields of regenerative medicine and rehabilitation, a convergence of disciplines known as regenerative rehabilitation; (2) provide translational examples of regenerative rehabilitation within the context of neuromuscular injuries and diseases; and (3) offer recommendations for ways to leverage activity dependence via combined therapy and technology, with the goal of enhancing long-term recovery...
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654364/practical-implications-of-the-2016-revision-of-the-world-health-organization-classification-of-lymphoid-and-myeloid-neoplasms-and-acute-leukemia
#11
John P Leonard, Peter Martin, Gail J Roboz
A major revision of the WHO classification of lymphoid and myeloid neoplasms and acute leukemia was released in 2016. A key motivation for this update was to include new information available since the 2008 version with clinical relevance for the diagnosis, prognosis, and therapy of patients. With > 100 entities described, it is important for the clinician to understand features that may be important in daily practice, whereas researchers need to incorporate the new classification scheme into study development and analysis...
June 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28654313/oral-insulin-delivery-in-a-physiologic-context
#12
Ehud Arbit, Miriam Kidron
Insulin remains indispensable to the treatment of diabetes, but its availability in injectable form only has hampered its timely and broader use. The development of an oral insulin remains an ultimate goal to both enhance ease of use, and to provide therapeutic advantages rooted in its direct delivery to the portal vein and liver. By mimicking the physiological path taken by pancreatic insulin, oral insulin is expected to have a distinct effect on the hepatic aspect of carbohydrate metabolism, hepatic insulin resistance, and, at the same time, avoid hyperinsulinemia and minimize the risk of hypoglycemia...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28654076/a-method-to-test-the-efficacy-of-handwashing-for-the-removal-of-emerging-infectious-pathogens
#13
Marlene K Wolfe, Daniele S Lantagne
Handwashing is widely recommended to prevent infectious disease transmission. However, little comparable evidence exists on the efficacy of handwashing methods in general. Additionally, little evidence exists comparing handwashing methods to determine which are most efficacious at removing infectious pathogens. Research is needed to provide evidence for the different approaches to handwashing that may be employed during infectious disease outbreaks. Here, a laboratory method to assess the efficacy of handwashing methods at removing microorganisms from hands and their persistence in rinse water is described...
June 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654068/fabrication-of-3d-carbon-microelectromechanical-systems-c-mems
#14
Bidhan Pramanick, Sergio O Martinez-Chapa, Marc Madou, Hyundoo Hwang
A wide range of carbon sources are available in nature, with a variety of micro-/nanostructure configurations. Here, a novel technique to fabricate long and hollow glassy carbon microfibers derived from human hairs is introduced. The long and hollow carbon structures were made by the pyrolysis of human hair at 900 °C in a N2 atmosphere. The morphology and chemical composition of natural and pyrolyzed human hairs were investigated using scanning electron microscopy (SEM) and electron-dispersive X-ray spectroscopy (EDX), respectively, to estimate the physical and chemical changes due to pyrolysis...
June 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653965/factors-influencing-the-underreporting-of-concussion-in-sports-a-qualitative-study-of-minor-hockey-participants
#15
Michael D Cusimano, Jane Topolovec-Vranic, Stanley Zhang, Sarah J Mullen, Mattew Wong, Gabriela Ilie
OBJECTIVE: The present study is to identify factors contributing to underreporting of concussion in adolescent athletes. DESIGN: Qualitative interviews. SETTING: Participants were interviewed in an office environment. PARTICIPANTS: Interviews were conducted with 31 minor hockey players, 10 parents, 6 coaches, 4 trainers, 2 managers, and one game official. Players were 13 to 15 year old. With selective sampling, an inductive approach of analyzing the interviews was undertaken and themes were identified and analyzed...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653957/the-lifecycle-of-the-ebola-virus-in-host-cells
#16
REVIEW
Dong-Shan Yu, Tian-Hao Weng, Xiao-Xin Wu, Frederick X C Wang, Xiang-Yun Lu, Hai-Bo Wu, Nan-Ping Wu, Lan-Juan Li, Hang-Ping Yao
Ebola haemorrhagic fever causes deadly disease in humans and non-human primates resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However, the mechanisms of EBOV lifecycle in host cells, including viral entry, membrane fusion, RNP formation, GP-tetherin interaction, and VP40-inner leaflet association remain poorly understood. This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28653940/review-medication-errors-and-strategies-for-their-prevention
#17
Muhammad Kashif Riaz, Mohammad Riaz, Abida Latif
Medication errors occur every day causing injury to the patients and even deaths. The health care professionals are not fully aware of the damages done by medication errors in terms of patients' discomfort and economic burden. There is a need to provide information about medication errors to health care providers. This article reviews research done on the various aspects of medication errors. The research work done on prescribing errors, transcribing errors, dispensing errors, administration errors and discharged summaries errors have been examined...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653867/association-between-the-single-assessment-numeric-evaluation-and-the-western-ontario-and-mcmaster-universities-osteoarthritis-index
#18
Brian Pietrosimone, Brittney A Luc, Austin Duncan, Susan A Saliba, Joseph M Hart, Christopher D Ingersoll
CONTEXT:   Patient-reported outcomes (PROs) evaluate how patients describe symptoms as well as level of physical function or quality of life. The Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index is one of the most common PROs used to assess disability in patients with knee osteoarthritis (OA), yet the Single Assessment Numeric Evaluation (SANE) is a single-question instrument that may improve the efficiency associated with the measurement of patient function. OBJECTIVE:   To determine the associations between (1) SANEFunction and the physical dysfunction subsection of the WOMAC index (WOMACDysfunction) before rehabilitation and after a 4-week therapeutic exercise intervention as well as (2) the percentage change in SANEFunction and WOMACDysfunction in people with knee OA after 4 weeks of therapeutic exercise...
June 2, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28653822/uniform-growth-of-sub-5-nanometer-high-%C3%AE%C2%BA-dielectrics-on-mos2-using-plasma-enhanced-atomic-layer-deposition
#19
Katherine M Price, Kirstin E Schauble, Felicia A McGuire, Damon B Farmer, Aaron D Franklin
Regardless of the application, MoS2 requires encapsulation or passivation with a high-quality dielectric, whether as an integral aspect of the device (as with top-gated field-effect transistors (FETs)) or for protection from ambient conditions. However, the chemically inert surface of MoS2 prevents uniform growth of a dielectric film using atomic layer deposition (ALD)-the most controlled synthesis technique. In this work, we show that a plasma-enhanced ALD (PEALD) process, compared to traditional thermal ALD, substantially improves nucleation on MoS2 without hampering its electrical performance, and enables uniform growth of high-κ dielectrics to sub-5 nm thicknesses...
June 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28653790/vigirank-for-statistical-signal-detection-in-pharmacovigilance-first-results-from-prospective-real-world-use
#20
Ola Caster, Lovisa Sandberg, Tomas Bergvall, Sarah Watson, G Niklas Norén
PURPOSE: vigiRank is a data-driven predictive model for emerging safety signals. In addition to disproportionate reporting patterns, it also accounts for the completeness, recency, and geographic spread of individual case reporting, as well as the availability of case narratives. Previous retrospective analysis suggested that vigiRank performed better than disproportionality analysis alone. The purpose of the present analysis was to evaluate its prospective performance. METHODS: The evaluation of vigiRank was based on real-world signal detection in VigiBase...
June 27, 2017: Pharmacoepidemiology and Drug Safety
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