Joe W Chiles, Ava C Wilson, Rachel Tindal, Kaleen Lavin, Samuel Windham, Harry B Rossiter, Richard Casaburi, Anna Thalacker-Mercer, Thomas W Buford, Rakesh Patel, J Michael Wells, Marcas M Bamman, Beatriz Y Hanaoka, Mark Dransfield, Merry-Lynn N McDonald
BACKGROUND: Skeletal muscle dysfunction is a common extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD). Alterations in skeletal muscle myosin heavy chain expression, with reduced type I and increased type II myosin heavy chain expression, are associated with COPD severity when studied in largely male cohorts. The objectives of this study were (1) to define an abnormal myofibre proportion phenotype in both males and females with COPD and (2) to identify transcripts and transcriptional networks associated with abnormal myofibre proportion in COPD...
April 22, 2024: Journal of Cachexia, Sarcopenia and Muscle