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chronic pulmonar pulmonary disease

Renata Spósito Roxo, Vivian Bertoni Xavier, Luiz Antônio Miorin, Andrea Olivares Magalhães, Yvoty Alves Dos Santos Sens, Vera Lúcia Dos Santos Alves
Introduction: Literature shows that patients undergoing hemodialysis present poor physical conditioning and low tolerance to exercise. They may also suffer from respiratory dysfunctions. The purpose of this study was to evaluate the effects of neuromuscular electrical stimulation on pulmonary function and functional capacity of patients with chronic kidney disease on hemodialysis. Methods: Forty adult patients with chronic kidney disease on hemodialysis were prospectively studied and randomized into two groups (control n = 20 and treatment n = 20)...
July 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
R K Osman, K Mortimer, G Bjune, A I El Sony
Background: Chronic respiratory disease (CRD) causes substantial morbidity and mortality. Although the global CRD epidemic collides with the tuberculosis (TB) epidemic in many low- and middle-income country settings, the risk of TB-associated CRD is not well described in countries with a high burden of TB. Methods: We recruited 136 patients with a history of sputum smear-positive pulmonary TB (PTB) from the TB clinic at Omdurman Teaching Hospital in Khartoum, Sudan, and 136 age- and sex-matched community controls, between 28 July 2013 and 30 December 2013...
September 2016: Public Health Action
M Guimarães, A Bugalho, A S Oliveira, J Moita, A Marques
There are currently no reliable instruments for assessing the onset and progression of chronic obstructive pulmonary disease (COPD) or predicting its prognosis. Currently, a comprehensive assessment of COPD including several objective and subjective parameters is recommended. However, the lack of biomarkers precludes a correct assessment of COPD severity, which consequently hampers adequate therapeutic approaches and COPD control. In the absence of a definition of "well-controlled disease", a consensus regarding COPD control will be difficult to reach...
May 2016: Revista Portuguesa de Pneumologia
A J Ferreira, A Reis, N Marçal, P Pinto, C Bárbara
Current guidelines differ slightly on the recommendations for treatment of Chronic Obstructive Pulmonary Disease (COPD) patients, and although there are some undisputed recommendations, there is still debate regarding the management of COPD. One of the hindrances to deciding which therapeutic approach to choose is late diagnosis or misdiagnosis of COPD. After a proper diagnosis is achieved and severity assessed, the choice between a stepwise or "hit hard" approach has to be made. For GOLD A patients the stepwise approach is recommended, whilst for B, C and D patients this remains debatable...
July 2016: Revista Portuguesa de Pneumologia
E Fragoso, S André, J P Boleo-Tomé, V Areias, J Munhá, J Cardoso
Chronic Obstructive Pulmonary Disease (COPD) phenotypes have become increasingly recognized as important for grouping patients with similar presentation and/or behavior, within the heterogeneity of the disease. The primary aim of identifying phenotypes is to provide patients with the best health care possible, tailoring the therapeutic approach to each patient. However, the identification of specific phenotypes has been hindered by several factors such as which specific attributes are relevant, which discriminant features should be used for assigning patients to specific phenotypes, and how relevant are they to the therapeutic approach, prognostic and clinical outcome...
March 2016: Revista Portuguesa de Pneumologia
J Ferreira, M Drummond, N Pires, G Reis, C Alves, C Robalo-Cordeiro
There is currently no consensus on the treatment sequence in chronic obstructive pulmonary disease (COPD), although it is recognized that early diagnosis is of paramount importance to start treatment in the early stages of the disease. Although it is fairly consensual that initial treatment should be with an inhaled short-acting beta agonist, a short-acting muscarinic antagonist, a long-acting beta-agonist or a long-acting muscarinic antagonist. As the disease progresses, several therapeutic options are available, and which to choose at each disease stage remains controversial...
January 2016: Revista Portuguesa de Pneumologia
Nívia L Nonato, Oliver A Nascimento, Rogelio P Padilla, Maria M de Oca, Carlos Tálamo, Gonzalo Valdivia, Carmen Lisboa, Maria V López, Bartolomé Celli, Ana Maria B Menezes, José R Jardim
Patients with chronic obstructive pulmonary disease (COPD) usually complain of symptoms such as cough, sputum, wheezing, and dyspnea. Little is known about clinical symptoms in individuals with restrictive ventilatory impairment. The aim of this study was to compare the prevalence and type of respiratory symptoms in patients with COPD to those reported by individuals with restrictive ventilatory impairment in the Proyecto Latinoamericano de Investigacion en Obstruccion Pulmonar study. Between 2002 and 2004, individuals ≥40 years of age from five cities in Latin America performed pre and post-bronchodilator spirometry and had their respiratory symptoms recorded in a standardized questionnaire...
August 2015: Chronic Respiratory Disease
Graciane Laender Moreira, Beatriz Martins Manzano, Mariana Rodrigues Gazzotti, Oliver Augusto Nascimento, Rogelio Perez-Padilla, Ana Maria Baptista Menezes, José Roberto Jardim
OBJECTIVE: To determine the underdiagnosis rate in new COPD cases at the end of a nine-year follow-up period-in the study designated "Projeto Latino-Americano de Investigação em Obstrução Pulmonar" (PLATINO, Latin-American Pulmonary Obstruction Investigation Project)-and compare that with the underdiagnosis rate during the initial phase of the study, as well as to identify the clinical features exhibited by the subjects who were not diagnosed until the end of the follow-up phase. METHODS: The study population comprised the 1,000 residents of the city of São Paulo, Brazil, who took part in the PLATINO study...
January 2014: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Yousser Mohammad, Rafea Shaaban, Bassam Abou Al-Zahab, Nikolai Khaltaev, Jean Bousquet, Basim Dubaybo
BACKGROUND: The burden of chronic respiratory disease (CRD) is alarming. International studies suggest that women with CRD are undersurveyed and underdiagnosed by physicians worldwide. It is unclear what the prevalence of CRD is in the general population of Syria, particularly among women, since there has never been a survey on CRD in this nation. The purpose of this study was to investigate the impact of different patterns of smoking on CRD in women. MATERIALS AND METHODS: We extracted data on smoking patterns and outcome in women from the Global Alliance Against Chronic Respiratory Diseases survey...
2013: International Journal of Chronic Obstructive Pulmonary Disease
Jade Ghosn, Jean-Paul Viard
Vitamin D plays a role in the synthesis of antibacterial peptids and in autophagy. Several studies have shown that low levels of vitamin D are associated with the susceptibility and the severity of acute infections on one hand, and with an unfavorable outcome of some chronic infections (such as HIV infection). Vitamin D supplementation improves response to treatment of some viral (such as chronic hepatitis C infection) or bacterial infections (such as pulmonar tuberculosis). Vitamin D supplementation demonstrated no benefit in reducing the incidence of pulmonary infections...
October 2013: La Presse Médicale
J Díez-Manglano, F López-García, J Barquero-Romero, N Galofré-Alvaro, L Montero-Rivas, P Almagro-Mena, J B Soriano
AIM: Osteoporosis is a frequent comorbidity in patients with chronic obstructive pulmonary disease (COPD). We have studied the risk of major osteoporotic fracture and hip fracture in patients with COPD. PATIENTS AND METHODS: A multicenter cross-sectional study was performed in Spain in 26 hospitals of 16 regional communities. Patients diagnosed with COPD who required admission to the Internal Medicine Service due to exacerbation of their respiratory disease were enrolled...
October 2011: Revista Clínica Española
André Volschan, Denilson Albuquerque, Bernardo Rangel Tura, Marcos Knibel, José Péricles Esteves, Luiz Carlos Bodanese, Francisco Silveira, João Pantoja, Paulo Cesar Pereira da Silva e Souza, João Mansur, Evandro Tinoco Mesquita
BACKGROUND: Pulmonary embolism is associated with high mortality in patients with hypotension or circulatory shock. However, the association between some clinical variables and mortality is still unclear in hemodynamically stable patients. OBJECTIVES: To derive an in-hospital mortality risk stratification model in hemodynamically stable patients with pulmonary embolism. METHODS: This is a prospective multicenter cohort study of 582 consecutive patients admitted in emergency units or intensive care units with clinically suspected pulmonary embolism and whose diagnosis was confirmed by one or more of the following tests: pulmonary arteriography, spiral CT angiography, magnetic resonance angiography, Doppler echocardiography, pulmonary scintigraphy, or venous duplex scan...
August 2009: Arquivos Brasileiros de Cardiologia
John Hebert da Silva Felix, Paulo César Cortez, Rodrigo Carvalho Sousa Costa, Simone Castelo Branco Fortaleza, Eanes Delgado Barros Pereira, Marcelo Alcantara Holanda
OBJECTIVE: To present a locally developed system of computer vision for use with HRCT images, designated SIStema para a Detecção e a quantificação de Enfisema Pulmonar (SISDEP, System to Detect and Quantify Pulmonary Emphysema), and to compare this system with a freeware system tool. METHODS: Thirty-three HRCT images scanned at the apex, hilum and base of the lungs of 11 patients with COPD were analyzed. The SISDEP was compared with the Osiris Medical Imaging Software Program regarding lung parenchyma segmentation, precision of the measurement of the cross-sectional area of the lungs in mm(2), mean lung density (MLD), relative area (RA) of the lung occupied by voxels with attenuation values < -950 hounsfield units (RA -950), 15th percentile point (Perc15) and visualization of hyperinflated areas using a color mask...
September 2009: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Maria Montes de Oca, Carlos Tálamo, Ronald J Halbert, Rogelio Perez-Padilla, Maria Victorina Lopez, Adriana Muiño, José Roberto B Jardim, Gonzalo Valdivia, Julio Pertuzé, Dolores Moreno, Ana Maria B Menezes
BACKGROUND: Recurrent exacerbations are common in COPD patients. Limited information exists regarding exacerbation frequency in COPD patients from epidemiologic studies. We examined the frequency of self-reported exacerbations and the factors influencing exacerbation frequency among COPD patients in a population-based study conducted in Latin America. METHODS: We used a post-bronchodilator FEV(1)/FVC ratio of < 0.70 to define COPD. Exacerbation was self-reported and defined by symptoms (deterioration of breathing symptoms that affected usual daily activities or caused missed work)...
July 2009: Chest
Judith Garcia-Aymerich, Alvar Agustí, Joan A Barberà, José Belda, Eva Farrero, Antoni Ferrer, Jaume Ferrer, Juan B Gáldiz, Joaquim Gea, Federico P Gómez, Eduard Monsó, Josep Morera, Josep Roca, Jaume Sauleda, Josep M Antó
A functional definition of chronic obstructive pulmonary disease (COPD) based on airflow limitation has largely dominated the field. However, a view has emerged that COPD involves a complex array of cellular, organic, functional, and clinical events, with a growing interest in disentangling the phenotypic heterogeneity of COPD. The present review is based on the opinion of the authors, who have extensive research experience in several aspects of COPD. The starting assumption of the review is that current knowledge on the pathophysiology and clinical features of COPD allows us to classify phenotypic information in terms of the following dimensions: respiratory symptoms and health status, acute exacerbations, lung function, structural changes, local and systemic inflammation, and systemic effects...
March 2009: Archivos de Bronconeumología
A S Buist, W M Vollmer, M A McBurnie
SETTING: Burden of Obstructive Lung Disease (BOLD) Initiative sites worldwide. OBJECTIVE: To measure the prevalence of chronic obstructive pulmonary disease (COPD) and its risk factors, investigate variation in prevalence across countries and develop standardized methods that can be used in industrialized and developing countries. DESIGN: Non-institutionalized adults aged > or =40 years were recruited using population-based sampling plans...
July 2008: International Journal of Tuberculosis and Lung Disease
Laura Barcelona, Marcelo Marín, Daniel Stamboulian
Betalactamases production is one of the main bacterial resistance mechanisms to betalactam antibiotics. The use of bectalactamases inhibitors combined with betalactam antibiotics allows the inactivation of certain betalactamases produced by Gram positive, Gram negative and anaerobic organisms, and even by mycobacteria. Betalactamases inhibitors are an improved therapeutic alternative compared with the other betalactam since, in most cases, they cover a wider antimicrobial spectrum than their analogues. Betalactamases enzimatic activity is specifically directed to the betalactam ring hydrolisis, producing a compound without antibacterial activity...
2008: Medicina
Cristiane Luchese, Ricardo Brandão, Renata de Oliveira, Cristina W Nogueira, Francielli Weber Santos
This study was designed to examine if diphenyl diselenide (PhSe)(2), an organoselenium compound, attenuates pulmonar and cerebral oxidative stress caused by sub-chronic exposure to CdCl(2). Male adult Swiss albino mice received CdCl(2) (10 micromol/kg, subcutaneously), 5 times/week, for 4 weeks. (PhSe)(2) (10 micromol/kg or 20 micromol/kg, orally) was given concomitantly with CdCl(2) to mice. A number of toxicological parameters in lung and brain of mice were examined including delta-aminolevulinic acid dehydratase (delta-ALA-D), superoxide dismutase (SOD) and catalase activities, lipid peroxidation, non-protein thiols (NPSH) and ascorbic acid content...
September 28, 2007: Toxicology Letters
Carlos Tálamo, Maria Montes de Oca, Ron Halbert, Rogelio Perez-Padilla, José Roberto B Jardim, Adriana Muiño, Maria Victorina Lopez, Gonzalo Valdivia, Julio Pertuzé, Dolores Moreno, Ana Maria B Menezes
BACKGROUND: COPD is a major worldwide problem with a rising prevalence. Despite its importance, there is a lack of information regarding underdiagnosis and misdiagnosis of COPD in different countries. As part of the Proyecto Latinoamericano de Investigación en Obstrucción Pulmonar study, we examined the relationship between prior diagnostic label and airway obstruction in the metropolitan areas of five Latin American cities (São Paulo, Santiago, Mexico City, Montevideo, and Caracas)...
January 2007: Chest
Ana Maria Baptista Menezes, José Roberto Jardim, Rogelio Pérez-Padilla, Aquiles Camelier, Fernanda Rosa, Oliver Nascimento, Pedro Curi Hallal
Chronic obstructive pulmonary disease (COPD) is now a major public health concern; deaths attributable to COPD in Latin America have increased by 65.0% in the last decade. This study was aimed at evaluating COPD prevalence and associated factors in adults (> 40 years) living in Greater Metropolitan São Paulo, Brazil. The study is part of the Proyecto Latinoamericano de Investigación en Obstrucción Pulmonar (The PLATINO Project), a multi-center survey on COPD burden in Latin America, with São Paulo as the first center where the project has been carried out...
September 2005: Cadernos de Saúde Pública
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