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https://www.readbyqxmd.com/read/29792716/options-to-improve-the-quality-of-kidney-grafts-from-expanded-criteria-donors-experimental-study
#1
J Molacek, V Opatrný, V Treska, R Matejka, O Hes
INTRODUCTION: There is a worldwide discrepancy between the number of donors and the number of organs needed for transplantation, leading to certain expansion of criteria, resulting in acceptance of donor organs. This means that organs with worse parenchymal qualities may be harvested for transplantation. One possibility, how to ameliorate the quality of these organs, is to change the concept of their preservation during cold ischemia or even after sudden circulatory arrest, prior to the collection of the organ itself...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29792262/chronic-kidney-disease-as-a-cardiovascular-risk-factor-lessons-from-kidney-donors
#2
REVIEW
Anna M Price, Nicola C Edwards, Manvir K Hayer, William E Moody, Richard P Steeds, Charles J Ferro, Jonathan N Townend
Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease but is often associated with other risks such as diabetes and hypertension and can be both a cause and an effect of cardiovascular disease. Although epidemiologic data of an independent association of reduced glomerular filtration rate with cardiovascular risk are strong, causative mechanisms are unclear. Living kidney donors provide a useful model for assessing the "pure" effects of reduced kidney function on the cardiovascular system...
May 9, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29791583/what-we-know-and-do-not-know-about-women-and-kidney-diseases-questions-unanswered-and-answers-unquestioned-reflection-on-world-kidney-day-and-international-woman-s-day
#3
G B Piccoli, M Al Rukhaimi, Zhi-Hong Liu, E Zakharova, A Levin
Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically women's kidney health on the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29791069/rethinking-performance-benchmarks-in-kidney-transplantation
#4
EDITORIAL
Kyle H Sheetz, Michael J Englesbe
Transplantation is a highly regulated field. Transplant centers answer to local, regional, and national authorities responsible for ensuring that patients have access to providers who give them the best chance at a good outcome. It is plausible that these efforts have contributed to improvements in kidney transplant outcomes over time. One-year patient and graft survival in the United States (U.S.) both now exceed 93%. Perhaps just as important, outcomes are more consistent. In one recent study, short-term survival rates following deceased donor kidney transplant only differed by 3% between low- and high-performing centers (1)...
May 23, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29791039/racial-differences-in-completion-of-the-living-kidney-donor-evaluation-process
#5
Komal Kumar, James M Tonascia, Abimereki D Muzaale, Tanjala S Purnell, Shane E Ottmann, Fawaz Al Ammary, Mary G Bowring, Anna Poon, Elizabeth A King, Allan B Massie, Eric K H Chow, Alvin G Thomas, Hao Ying, Marvin Borja, Jonathan M Konel, Macey Henderson, Andrew M Cameron, Jacqueline M Garonzik-Wang, Dorry L Segev
Racial disparities in living donor kidney transplantation (LDKT) persist but the most effective target to eliminate these disparities remains unknown. One potential target could be delays during completion of the live donor evaluation process. We studied racial differences in progression through the evaluation process for 247 African American (AA) and 664 non-AA living donor candidates at our center between January 2011-March 2015. AA candidates were more likely to be obese (38% vs. 22%: p<0.001), biologically-related (66% vs...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29790388/graft-function-assessment-in-mouse-models-of-single-and-dual-kidney-transplantation
#6
Lei Wang, Ximing Wang, Shan Jiang, Jin Wei, Jacentha Buggs, Liying Fu, Jie Zhang, Ruisheng Liu
Animal models of kidney transplantation (KTX) are widely used in studying immune response of hosts to implanted grafts. Additionally, KTX can be used in generating kidney-specific knockout animal models by transplantation of kidneys from donors with global knockout of a gene to wild type recipients or vise verse. Dual kidney transplantation (DKT) provides a more physiological environment for recipients than single kidney transplantation (SKT). However, DKT in mice is rare due to technical challenges. In this study, we successfully performed DKT in mice and compared the hemodynamic response and graft function with SKT...
May 23, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29790290/tacrolimus-prevents-von-willebrand-factor-secretion-by-allostimulated-human-glomerular-endothelium
#7
S Béland, O Désy, R V Ung, P Vallin, E Latulippe, J Riopel, S A De Serres
Little is known about the endothelial injury caused directly by circulating donor-specific antibodies during antibody-mediated rejection. Von Willebrand factor (vWF) is a highly thrombotic glycoprotein stored in Weibel-Palade bodies in endothelial cells. It has been shown that its secretion is triggered by allostimulation. Calcineurin-like phosphatases regulate pathways involved in vWF secretion. Therefore, we hypothesized that tacrolimus would prevent alloantibody-induced glomerular lesions in part via inhibition of vWF secretion from endothelial cells...
May 22, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29790212/dopamine-in-transplantation-written-off-or-comeback-with-novel-indication
#8
REVIEW
Peter Schnuelle, Urs Benck, Benito A Yard
Renal-dose dopamine has fallen out of favor in the intensive care unit (ICU) during past years due to its ineffectiveness to prevent impending or to ameliorate overt renal failure in the critically ill. By contrast, growing evidence indicates that low-dose dopamine administered to the stable organ donor after brain death confirmation improves the clinical course of transplanted organs after kidney and heart transplantation. Ensuring a thorough monitoring for potential circulatory side effects, employment of dopamine at a dose of 4 μg/kg per minute is safe in the deceased donor...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29790081/transplant-renal-vein-thrombosis-in-a-recipient-with-aberrant-venous-anatomy
#9
Lyndsey Thiessen, Sarah MacDonell, Chris Wall, Preman Jacob, Ahmed Shoker, Michael A J Moser
Renal vein thrombosis in a transplanted kidney is an uncommon but critical complication that can result in graft loss if management is delayed. A 31-year-old male with known atresia of the inferior vena cava who received a deceased donor renal transplant 7 years previously presented to hospital with severe graft site pain and a week of nausea, vomiting, and chills. Serum creatinine was markedly elevated from baseline. Sonographic examination revealed external iliac vein thrombosis with extension of the thrombus into the transplant renal vein...
May 22, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29789431/clinical-and-pathology-findings-associate-consistently-with-larger-glomerular-volume
#10
Aleksandar Denic, Jerry Mathew, Venkata V Nagineni, R Houston Thompson, Bradley C Leibovich, Lilach O Lerman, John C Lieske, Mariam P Alexander, Joshua J Augustine, Walter K Kremers, Andrew D Rule
Background Glomerular volume increases when demand exceeds nephron supply, which may lead to glomerulosclerosis. It is unclear if determinants of glomerular volume are consistent between populations that differ by severity of comorbidities. Methods We studied kidney biopsy specimens from living kidney donors ( n =2453) and patients who underwent radical nephrectomy for a renal tumor ( n =780). We scanned specimen sections into high-resolution digital images, manually traced glomerular profiles, and calculated mean glomerular volumes using the Weibel-Gomez stereologic formula (separately for nonsclerosed glomeruli and globally sclerosed glomeruli)...
May 22, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29788896/association-between-delayed-graft-function-dgf-biomarkers-and-long-term-outcomes-after-living-donor-kidney-transplantation
#11
Zahra Sahraei, Mona Mehdizadeh, Jamshid Salamzadeh, Mohsen Nafar, Azadeh Eshraghi
BACKGROUND AND OBJECTIVES: The Association between preoperative Urine Neutrophil Gelatinase-associated Lipocalin (uNGAL) and interlukin-18 (uIL-18) with poor 1-year allograft function has been shown in deceased-donor kidney transplant recipients previously, and also these markers could predict 3-month allograft function. However, it is unknown whether there is any association between these postoperative biomarkers with important recipient outcomes beyond this time in live-donor transplants...
May 21, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29787519/population-health-ethnicity-and-rate-of-living-donor-kidney-transplantation
#12
Rhiannon D Reed, Deirdre Sawinski, Brittany A Shelton, Paul A MacLennan, Michael Hanaway, Vineeta Kumar, Dustin Long, Robert S Gaston, Meredith L Kilgore, Bruce A Julian, Cora E Lewis, Jayme E Locke
BACKGROUND: Living donor kidney transplantation has declined in the United States since 2004, but the relationship between population characteristics and rate of living donation is unknown. The goal of our study was to use data on general population health and socioeconomic status to investigate the association with living donation. METHODS: This cross-sectional, ecological study used population health and socioeconomic status data from the CDC Behavioral Risk Factor Surveillance System (BRFSS) to investigate the association with living donation...
May 22, 2018: Transplantation
https://www.readbyqxmd.com/read/29786954/urinary-metabolites-predict-prolonged-duration-of-delayed-graft-function-in-dcd-kidney-transplant-recipients
#13
S Kostidis, J R Bank, D Soonawala, E Nevedomskaya, C van Kooten, O A Mayboroda, J W de Fijter
Extending kidney donor criteria, including donation after circulatory death (DCD), has resulted in increased rates of delayed graft function (DGF) and primary nonfunction. Here, we used Nuclear Magnetic Resonance (NMR) spectroscopy to analyze the urinary metabolome of DCD transplant recipients at multiple time points (days 10, 42, 180 and 360 after transplantation). The aim was to identify markers that predict prolonged duration of functional DGF (fDGF). Forty-seven metabolites were quantified and their levels were evaluated in relation to fDGF...
May 22, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29786877/morphomic-malnutrition-score-a-standardized-screening-tool-for-severe-malnutrition-in-adults
#14
Christopher Lee, Erica Raymond, Brian A Derstine, Joshua M Glazer, Rebecca Goulson, Avinash Rajasekaran, Jill Cherry-Bukowiec, Grace L Su, Stewart C Wang
BACKGROUND: Granular diagnostic criteria for adult malnutrition are lacking. OBJECTIVE: This study uses analytic morphomics to define the Morphomic Malnutrition Score (MMS), a robust screening tool for severe malnutrition. METHODS: The study population (n = 643) consisted of 2 cohorts: 1) 124 emergency department patients diagnosed with severe malnutrition by a registered dietitian (RD) and an available computed tomography (CT) scan within 2 days of RD evaluation, and 2) 519 adult kidney donor candidates to represent a healthy cohort...
May 22, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29786042/early-immunosuppressive-exposure-of-enteric-coated-mycophenolate-sodium-plus-tacrolimus-associated-with-acute-rejection-in-expanded-criteria-donor-kidney-transplantation
#15
Chen-Guang Ding, Li-Zi Jiao, Feng Han, He-Li Xiang, Pu-Xun Tian, Xiao-Ming Ding, Xiao-Ming Pan, Xiao-Hui Tian, Yang Li, Jin Zheng, Wu-Jun Xue
Background: Immunosuppressive agents are still inefficient in preventing biopsy-proven acute rejection (BPAR) after expanded criteria donor (ECD) kidney transplantation. The aim of this study was to investigate the relationships between early immunosuppressive exposure and the development of BPAR. Methods: We performed a retrospective study of 58 recipients of ECD kidney transplantation treated with enteric-coated-mycophenolate sodium, tacrolimus (Tac), and prednisone...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785719/children-s-experiences-and-expectations-of-kidney-transplantation-a-qualitative-interview-study
#16
Rachael C Walker, Derisha Naicker, Tonya Kara, Suetonia C Palmer
RATIONALE AND OBJECTIVE: Kidney transplantation offers improved quality of life and life expectancy compared with dialysis for children. This study aims to understand the experiences and expectations of children during the kidney transplantation process to inform clinical care. STUDY DESIGN: Face-to-face, semi-structured interviews. SETTING AND PARTICIPANTS: We interviewed 13 children and adolescents aged between 7 and 17 years old in New Zealand who had received a kidney transplantation...
May 21, 2018: Nephrology
https://www.readbyqxmd.com/read/29783575/re-use-and-outcomes-of-kidneys-from-donation-after-circulatory-death-donors-in-the-united-states
#17
David A Goldfarb
No abstract text is available yet for this article.
June 2018: Journal of Urology
https://www.readbyqxmd.com/read/29782007/intraportal-transplantation-of-pancreatic-islets-in-mouse-model
#18
Rahul Khatri, Birte Hussmann, Divya Rawat, Ali Osman Gürol, Thomas Linn
Pancreatic islet transplantation to reduce hyperglycemia is highly successful in rodents with chemically-induced diabetes. The most common transplantation site in experimental islet transplantation is the kidney capsule. However, as less is known about the interaction of pancreatic islets with blood constituents, it also makes sense to utilize the portal vein approach in experimental islet transplantation. This protocol demonstrates an intraportal islet transplantation technique in NMRI nude mice. Streptozotocin (180 mg/kg) is injected intraperitoneally to induce hyperglycemia in recipient mice...
May 5, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781952/optimizing-temperature-and-oxygen-supports-long-term-culture-of-human-islets
#19
Hirotake Komatsu, Jeffrey Rawson, Leonard Medrano, Colin A Cook, Alyssa Barriga, Nelson Gonzalez, Mayra Salgado, Keiko Omori, Fouad Kandeel, Yu-Chong Tai, Yoko Mullen
BACKGROUND: Islet transplantation is a promising treatment for type-1 diabetes; however, donor shortage is a concern. Even when a pancreas is available, low islet yield limits the success of transplantation. Islet culture enables pooling of multiple low-yield isolations into an effective islet mass, but isolated islets rapidly deteriorate under conventional culture conditions. Oxygen depletion in the islet core, which leads to central necrosis and volume loss, is one of the major reasons for this deterioration...
May 16, 2018: Transplantation
https://www.readbyqxmd.com/read/29779841/adrenal-function-after-laparoscopic-nephrectomy-the-zurich-clinical-trial
#20
Hans Albin Gritsch
This manuscript reviews the outcomes of a European clinical trial to evaluate the effects of living kidney donation on adrenal function. The study shows that left-sided donor nephrectomy is associated with transiently reduced adrenocortical responsiveness, which returns to baseline after 28 d.
May 17, 2018: European Urology Focus
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