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Interleukin-10

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https://www.readbyqxmd.com/read/28719891/serum-interleukin-10-levels-correlate-with-cerebrospinal-fluid-amyloid-beta-deposition-in-alzheimer-disease-patients
#1
Lucio D'Anna, Samir Abu-Rumeileh, Martina Fabris, Cinzia Pistis, Antonio Baldi, Nova Sanvilli, Francesco Curcio, Gian Luigi Gigli, Sebastiano D'Anna, Mariarosaria Valente
BACKGROUND AND OBJECTIVE: In Alzheimer disease (AD) inflammation becomes evident throughout the course of the disease. However, the association between inflammation, cognitive impairment, and cerebrospinal biomarkers (Aβ42, t-tau, p-tau181, and Aβ42/p-tau181 ratio) is poorly understood. METHODS: A large panel of inflammatory cytokines (interleukin [IL]-1β, IL-1ra, IL-2, IL-4, IL-6, IL-10, IL-17, interferon-γ, tumor necrosis factor-α, and vascular endothelial growth factor) was analyzed using a multiplex immunoassay in 27 patients with a diagnosis of AD dementia and in 18 control subjects...
July 19, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/28719789/waist-to-height-ratio-in-indian-women-comparison-with-traditional-indices-of-obesity-association-with-inflammatory-biomarkers-and-lipid-profile
#2
Sharvari Dilip Malshe, Shobha Anand Udipi
We compared waist-to-height ratio (WHtR) with traditional anthropometric indices in healthy women aged 21 to 45 years from urban slums of Mumbai city, India. Lipid profile and inflammatory markers were measured in a subsample of 200 women, and their relationship with WHtR was examined. Mean WHtR was 0.50 ± 0.1, but a little more than half (51.9%) of the women had WHtR ≥0.50. WHtR could correctly identify centrally obese adult women, even when they were categorized as healthy or normal according to body mass index, waist circumference, waist to hip ratio, and percentage body fat...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28713893/interleukin%C3%A2-6-rna-knockdown-ameliorates-acute-lung-injury-induced-by-intestinal-ischemia-reperfusion-in-rats-by-upregulating-interleukin%C3%A2-10-expression
#3
Bing Yuan, Liu-Lin Xiong, Mu-Dong Wen, Piao Zhang, Hong-Yu Ma, Ting-Hua Wang, Yun-Hui Zhang
Acute lung injury (ALI) is a common complication following intestinal ischemia/reperfusion (II/R) injury and contributes to the associated high mortality rate. However, the underlying mechanism is poorly understood and treatments are limited. RNA interference (RNAi) has been demonstrated to provide a promising disease treatment strategy both in vitro and in vivo. Therefore, the present study aimed to test whether blocking the proinflammatory cytokine IL‑6 by RNAi may protect the lungs from remote organ injury following II/R, and to investigate the potential underlying mechanisms...
July 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713870/il-10-induces-a-stat3-dependent-autoregulatory-loop-in-th2-cells-that-promotes-blimp-1-restriction-of-cell-expansion-via-antagonism-of-stat5-target-genes
#4
Amanda C Poholek, Dragana Jankovic, Alejandro V Villarino, Franziska Petermann, Angela Hettinga, Dror S Shouval, Scott B Snapper, Susan M Kaech, Stephen R Brooks, Golnaz Vahedi, Alan Sher, Yuka Kanno, John J O'Shea
Blimp-1 expression in T cells extinguishes the fate of T follicular helper cells, drives terminal differentiation, and limits autoimmunity. Although various factors have been described to control Blimp-1 expression in T cells, little is known about what regulates Blimp-1 expression in T helper 2 (TH2) cells and the molecular basis of its actions. We report that signal transducer and activator of transcription 3 (STAT3) unexpectedly played a critical role in regulating Blimp-1 in TH2 cells. Furthermore, we found that the cytokine interleukin-10 (IL-10) acted directly on TH2 cells and was necessary and sufficient to induce optimal Blimp-1 expression through STAT3...
October 2016: Science Immunology
https://www.readbyqxmd.com/read/28712480/bee-venom-acupuncture-reduces-interleukin-6-increases-interleukin-10-and-induces-locomotor-recovery-in-a-model-of-spinal-cord-compression
#5
Raquel Nascimento de Souza, Fernanda Kohn Silva, Magda Alves de Medeiros
Spinal cord injuries (SCIs) initiate a series of molecular and cellular events in which inflammatory responses can lead to major neurological dysfunctions. The present study aims to investigate whether bee venom (BV) acupuncture applied at acupoints ST36 (Zusanli) and GV3 (Yaoyangquan) could minimize locomotor deficits and the magnitude of neural tissue losses, and change the balance between pro- and anti-inflammatory cytokines after an SCI by compression. Wistar rats were subjected to an SCI model by compression in which a 2-French Fogarty embolectomy catheter was inflated in the extradural space...
June 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28708587/sodium-fluoride-induces-renal-inflammatory-responses-by-activating-nf-%C3%AE%C2%BAb-signaling-pathway-and-reducing-anti-inflammatory-cytokine-expression-in-mice
#6
Qin Luo, Hengmin Cui, Huidan Deng, Ping Kuang, Huan Liu, Yujiao Lu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao
Fluoride is widely distributed in the environment and often results in adverse health effects on animals and human beings. It has been proved that fluoride can induce inflammatory responses in vitro. However, very limited reports are focused on fluoride-induced inflammatory responses in vivo. In this study, mice were used to investigate sodium fluoride (NaF) induced renal inflammatory responses and the potential mechanism by using the methods of pathology, biochemistry, enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (qRT-PCR) and western blot...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28707331/epstein-barr-virus-lytic-cycle-involvement-in-diffuse-large-b-cell-lymphoma
#7
Melina Cohen, Aldana Georgina Vistarop, Fuad Huaman, Marina Narbaitz, Fernanda Metrebian, Elena De Matteo, María Victoria Preciado, Paola Andrea Chabay
Epstein-Barr virus (EBV)-mediated B cell transformation is achieved predominantly through the action of latent proteins, but recent evidence suggests that lytic EBV replication has also a certain pathogenic role in lymphomagenesis, at least in the early phases of cell transformation. Particularly, in diffuse large B cell lymphoma (DLBCL), the EBV lytic cycle is by and large unexplored, so to disclose lytic cell contribution to lymphomagenesis, our aim was to evaluate viral early and late lytic gene expression in relation to several immune response markers in a series of EBV+ DLBCL from Argentina...
July 14, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28702476/regulatable-transgene-expression-for-prevention-of-chemotherapy-induced-peripheral-neuropathy
#8
Daisuke Kawata, Zetang Wu
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating complication associated with drug treatment of cancer for which there are no effective strategies of prevention or treatment. In this study, we examined the effect of intermittent expression of neurotophin-3 (NT-3) or interleukin-10 (IL-10) from replication-defective herpes simplex virus (HSV)-based regulatable vectors delivered by subcutaneous inoculation to the dorsal root ganglion (DRG) on the development of paclitaxel-induced peripheral neuropathy...
September 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28700093/interleukin-10-release-from-astrocytes-suppresses-neuronal-apoptosis-via-the-tlr2-nf%C3%AE%C2%BAb-pathway-in-a-neonatal-rat-model-of-hypoxic-ischemic-brain-damage
#9
Mu Lan He, Ze Yu Lv, Xia Shi, Ting Yang, Yun Zhang, Ting-Yu Li, Jie Chen
The biological function of Interleukin-10 (IL-10) and the relationship between IL-10 secretion and the Toll-like receptor 2 (TLR2) expression levels in the central nervous system following hypoxic-ischemic brain damage (HIBD) are poorly understood. Here, we intend to elucidate the biological function and mechanism of IL-10 secretion following HIBD. In the current study, we used a neonatal rat model of HIBD and found that rats injected with adeno-associated virus (AAV)-IL-10-shRNA (short hairpin RNA) exhibited partially impaired learning and memory function compared to rats administered AAV-control-shRNA...
July 12, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28696534/a-fusion-protein-of-interleukin-4-and-interleukin-10-protects-against-blood-induced-cartilage-damage-in-vitro-and-in-vivo
#10
Lize F D van Vulpen, Jelena Popov-Celeketic, Monique E R van Meegeren, Katja Coeleveld, Jacob M van Laar, C Erik Hack, Roger E G Schutgens, Simon C Mastbergen, Floris P J G Lafeber
BACKGROUND: Joint damage still causes significant morbidity in hemophilia. It results from synovial inflammation and direct cartilage-degenerating properties of blood components. Interleukin (IL)-4 and IL-10 have been shown to protect cartilage from blood-induced damage. Recently an IL4-10 fusion protein has been developed to combine the function of IL-4 and IL-10 and increase their bioavailability. OBJECTIVES: In this study it is evaluated whether this IL4-10 fusion protein protects against blood-induced joint damage...
July 11, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28694775/yoga-meditation-and-mind-body-health-increased-bdnf-cortisol-awakening-response-and-altered-inflammatory-marker-expression-after-a-3-month-yoga-and-meditation-retreat
#11
B Rael Cahn, Matthew S Goodman, Christine T Peterson, Raj Maturi, Paul J Mills
Thirty-eight individuals (mean age: 34.8 years old) participating in a 3-month yoga and meditation retreat were assessed before and after the intervention for psychometric measures, brain derived neurotrophic factor (BDNF), circadian salivary cortisol levels, and pro- and anti-inflammatory cytokines. Participation in the retreat was found to be associated with decreases in self-reported anxiety and depression as well as increases in mindfulness. As hypothesized, increases in the plasma levels of BDNF and increases in the magnitude of the cortisol awakening response (CAR) were also observed...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28692940/betulinic-acid-and-fluvastatin-exhibits-synergistic-effect-on-toll-like-receptor-4-mediated-anti-atherogenic-mechanism-in-type-ii-collagen-induced-arthritis
#12
Limi Elizabeth Mathew, Vrinda Rajagopal, Helen A
Cardiovascular disease (CVD) is a major problem during rheumatoid arthritis which leads to morbidity and mortality in arthritic patients. So the present study emphasizes combinatorial effect of Betulinic acid, a triterpenoid and fluvastatin, an HMG CoA reductase inhibitor on atherogenesis during arthritis. Arthritis was induced by bovine type II collagen dissolved in 0.01M acetic acid at a concentration of 4mg/mL and emulsified in equal volume of incomplete Freund's adjuvant. Betulinic acid (2mg/kg) and fluvastatin (5mg/kg) alone and in combination was administered orally from day 14 to 60...
July 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28692323/identifying-inhibitors-of-inflammation-a-novel-high-throughput-maldi-tof-screening-assay-for-salt-inducible-kinases-siks
#13
Rachel E Heap, Anthony G Hope, Lesley-Anne Pearson, Kathleen M S E Reyskens, Stuart P McElroy, C James Hastie, David W Porter, J Simon C Arthur, David W Gray, Matthias Trost
Matrix-assisted laser desorption/ionization time-of-flight (MALDI TOF) mass spectrometry has become a promising alternative for high-throughput drug discovery as new instruments offer high speed, flexibility and sensitivity, and the ability to measure physiological substrates label free. Here we developed and applied high-throughput MALDI TOF mass spectrometry to identify inhibitors of the salt-inducible kinase (SIK) family, which are interesting drug targets in the field of inflammatory disease as they control production of the anti-inflammatory cytokine interleukin-10 (IL-10) in macrophages...
July 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28691653/molecular-biochemical-characterization-and-assessment-of-immunogenic-potential-of-cofactor-independent-phosphoglycerate-mutase-against-leishmania-donovani-a-step-towards-exploring-novel-vaccine-candidate
#14
Rati Tandon, Sharat Chandra, Rajendra Kumar Baharia, Pragya Misra, Sanchita DAS, Keerti Rawat, Mohammad Imran Siddiqi, Shyam Sundar, Anuradha Dube
Despite immense efforts, vaccine against visceral leishmaniasis has yet not been developed. Earlier our proteomic study revealed a novel protein, cofactor-independent phoshoglycerate mutase (LdiPGAM), an important enzyme in glucose metabolism, in T helper cells type 1 (Th1) stimulatory region of soluble Leishmania donovani antigen. In this study, LdiPGAM was biochemically and molecularly characterized and evaluated for its immunogenicity and prophylactic efficacy against L. donovani. Immunogenicity of recombinant LdiPGAM (rLdiPGAM) was initially assessed in naïve hamsters immunized with it by analysing mRNA expression of inducible nitric oxide (NO) synthase (iNOS) and other Th1/T helper cells type 2 cytokines, which revealed an upregulation of Th1 cytokines along with iNOS...
July 10, 2017: Parasitology
https://www.readbyqxmd.com/read/28688647/effect-of-hypothermia-on-splenic-leukocyte-modulation-and-survival-duration-in-severely-septic-rats
#15
Rhett N Willis, Eric J Charles, Christopher A Guidry, Mahendra D Chordia, Stephen W Davies, Zequan Yang, Robert G Sawyer
BACKGROUND: Therapeutic hypothermia (HT) in severe septic shock is associated with prolonged survival. We hypothesized that moderate HT would prolong survival and modulate the inflammatory response in rats with septic shock by exerting its therapeutic effect on splenic leukocytes. MATERIALS AND METHODS: Severe septic shock was created in rats by cecal ligation and incision (CLI). One hour after CLI or laparotomy, rats were randomized to sham, normothermia (NT), or 4 h of HT followed by 2 h of rewarming...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28683149/tlr2-and-interleukin-10-are-involved-in-bacteroides-fragilis-mediated-prevention-of-dss-induced-colitis-in-gnotobiotic-mice
#16
Yi-Chih Chang, Yung-Hao Ching, Chien-Chao Chiu, Ju-Yun Liu, Shao-Wen Hung, Wen-Ching Huang, Yen-Te Huang, Hsiao-Li Chuang
BACKGROUND AND AIMS: Bacteroides fragilis (BF) are Gram-negative anaerobe symbionts present in the colon. Recent studies have reported the beneficial role of BF in maintaining intestinal homeostasis, stimulating host immunologic development, and preventing infectious colitis caused by pathogenic bacteria. Our previous studies showed that monocolonization of germ-free mice with BF significantly reduced colon inflammations and damage. METHODS: In order to investigate the Toll-like receptor-2 (TLR2), TLR4, and interleukin 10 (IL-10) molecular signaling pathways involved in BF-mediated prevention of dextran sulfate sodium (DSS)-induced colitis...
2017: PloS One
https://www.readbyqxmd.com/read/28681096/anticonvulsant-effect-of-swertiamarin-against-pilocarpine-induced-seizures-in-adult-male-mice
#17
Xian-Hua Deng, Xiao Zhang, Jing Wang, Peng-Sheng Ma, Lin Ma, Yang Niu, Tao Sun, Ru Zhou, Jian-Qiang Yu
Epilepsy is one of the common and major neurological disorders, approximately a third of the individuals with epilepsy suffer from seizures and not able to successfully respond to available medications. Current study was designed to investigate whether Swertiamarin (Swe) had anticonvulsant activity in the pilocarpine (PILO)-treated mice. Thirty minutes prior to the PILO (280 mg/kg) injection, the mice were administrated with Swe (50, 150, and 450 mg/kg) and valproate sodium (VPA, 200 mg/kg) once. Seizures and electroencephalography (EEG) were observed, and then the mice were killed for Nissl, Fluoro-jade B (FJB) staining...
July 5, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28680752/oral-il-10-suppresses-colon-carcinogenesis-via-elimination-of-pathogeniccd4-t-cells-and-induction-of-antitumor-cd8-t-cell-activity
#18
Tao Gu, Magdia De Jesus, Heather C Gallagher, Thomas P Burris, Nejat K Egilmez
An oral sustained-release formulation of Interleukin-10 suppressed tumor growth and enhanced survival in the APC(min/+)/Bacteroides fragilis spontaneous colon cancer model. Therapeutic benefit was associated with a 5-fold reduction in CD4(+)RORγt(+)Foxp3(-)IL-17(+) T-helper cell, CD4(+)RORγt(+)Foxp3(+)IL-17(+) pathogenic T-regulatory cell and CD4(+)RORγt(-)Foxp3(+)IL-17(-) conventional T-regulatory cell numbers and a concurrent 2-fold enhancement in CD8(+) T-cell activity in the colon. Selective subset depletion and functional blockade studies demonstrated that at steady-state CD4(+)RORγt(+)IL-17(+) T-cell subsets and CD4(+)Foxp3(+) cTreg supported tumorigenesis, whereas CD8(+) cytotoxic T-lymphocytes impeded tumor progression following IL-10 therapy...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28678006/macrophage-dysfunction-initiates-colitis-during-weaning-of-infant-mice-lacking-the-interleukin-10-receptor
#19
Naresh S Redhu, Vasudevan Bakthavatchalu, Evan A Conaway, Dror S Shouval, Amy M Tsou, Jeremy A Goettel, Amlan Biswas, Chuanwu Wang, Michael Field, Werner Muller, Andre Bleich, Ning Li, Georg K Gerber, Lynn Bry, James G Fox, Scott B Snapper, Bruce H Horwitz
Infants with defects in the interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease. Whether IL10R regulates lamina propria macrophage function during infant development in mice and whether macrophage-intrinsic IL10R signaling is required to prevent colitis in infancy is unknown. Here we show that although signs of colitis are absent in IL10R-deficient mice during the first 2 weeks of life, intestinal inflammation and macrophage dysfunction begin during the 3(rd) week of life, concomitant with weaning and accompanying diversification of the intestinal microbiota...
July 5, 2017: ELife
https://www.readbyqxmd.com/read/28677995/role-of-adipocytokines-in-the-pathophysiology-of-migraine-a-cross-sectional-study
#20
Clara Domínguez, Alba Vieites-Prado, María Pérez-Mato, Tomás Sobrino, Xiana Rodríguez-Osorio, Ana López, Francisco Campos, Francisco Martínez, José Castillo, Rogelio Leira
Background Obesity is a risk factor for migraine and headache chronification. Adipocytokines may be involved in this correlation. Objective To relate serum adipocytokine levels to clinical and biochemical parameters associated with migraine. Methods We measured levels of leptin, adiponectin and other inflammatory (interleukin 6, interleukin 10, tumor necrosis factor α, high sensitivity C-reactive protein) and endothelial (pentraxin 3, soluble TNF-like weak inducer of apoptosis) molecules potentially related to migraine pathophysiology in a group of migraine patients (IHS 2013) and healthy controls...
January 1, 2017: Cephalalgia: An International Journal of Headache
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