Marianne Westberg, Frede Frihagen, Ole-Christian Brun, Wender Figved, Bjarne Grøgaard, Haldor Valland, Helge Wangen, Finnur Snorrason
BACKGROUND: Surgical site infection (SSI) is a feared complication in hip arthroplasty, especially following femoral neck fracture in the elderly, associated with substantially increased morbidity, mortality, and costs. Gentamicin-containing collagen sponges are widely used for prevention of SSIs, but their effectiveness in joint replacement surgery remains unclear. METHODS: We performed a multicenter, randomized trial between February 2011 and July 2013. Eligible patients with femoral neck fracture undergoing hemiarthroplasty were randomly assigned to receive either intravenous antimicrobial prophylaxis alone or with the addition of 2 gentamicin-containing collagen sponges into the hip joint perioperatively...
June 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America