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Cervical intraepithelial neoplasia

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https://www.readbyqxmd.com/read/28229232/comparison-of-cure-rates-in-women-treated-with-cold-coagulation-versus-lletz-cervical-treatment-for-cin2-3-on-pretreatment-cervical-punch-biopsies-a-retrospective-cohort-study
#1
Dimitrios Papoutsis, Martyn Underwood, William Parry-Smith, Jane Panikkar
PURPOSE: To compare the cure rates between women who were treated with cold-coagulation versus large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia grade 2 (CIN2) or 3 (CIN3) on pretreatment cervical punch biopsies. METHODS: This was a retrospective cohort study of women having had a single cervical treatment for CIN2 or CIN3 on pretreatment cervical punch biopsies between 2010 and 2011. The cure rates were defined as the absence of any dyskaryosis (mild/moderate/severe) on cytology tests during follow-up and were determined at 6 and 12 months after treatment...
February 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28221188/treatment-of-cervical-intraepithelial-neoplasia-patients-preferences-for-surgery-or-immunotherapy-with-imiquimod
#2
Margot M Koeneman, Brigitte A Essers, Cornelis G Gerestein, Anna J M van de Sande, Rogier J N T M Litjens, Dieuwke Boskamp, Medi F J Goossens, Heleen J Beekhuizen, Roy F P M Kruitwagen, Arnold J Kruse, Carmen D Dirksen
OBJECTIVE: Imiquimod has been studied as a noninvasive pharmacological treatment alternative to large loop excision of the transformation zone (LLETZ) for high-grade cervical intraepithelial neoplasia (CIN), to prevent long-term obstetric complications from surgical treatment. This study aims to investigate womens' preferences for treatment of high-grade CIN with imiquimod or LLETZ. METHODS: A labeled discrete choice experiment was conducted among 100 women with abnormal cervical cytology in 5 hospitals in the Netherlands between March 2014 and December 2015...
February 17, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28214205/synchronous-carcinosarcoma-of-the-uterine-cervix-with-adenoid-basal-carcinoma-and-cervical-intraepithelial-neoplasia-iii-a-case-report-and-literature-review
#3
Yuan Lin, Hanrui Chen, Ziyin Ye, Li Ding, Qinghua Cao, Ling Xue
Carcinosarcoma and adenoid basal carcinoma (ABC) are both rare lesions in uterine cervix. There were only 5 cases of cervical carcinosarcoma combined with ABC and/without cervical intraepithelial neoplasia (CIN) reported in English literature. These limited studies showed that there was a strong association between HPV, carcinosarcoma, ABC and CIN, suggesting a common etiology for these lesions. Here, we present the case of a 65-year-old woman with cervical carcinosarcoma combined with ABC and CIN III. However, HPV-16, 18, 31 and 33 was negative in the cervical carcinosarcoma tissue by in situ hybridization detection...
February 7, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28214204/detection-of-occult-endocervical-glandular-dysplasia-in-cervical-conization-specimens-for-squamous-lesions
#4
F Sopracordevole, N Clemente, L Alessandrini, J Di Giuseppe, F Cigolot, M Buttignol, A Ciavattini, V Canzonieri
The aim of this work was to evaluate the incidence of occult cervical glandular intraepithelial neoplasia (CGIN) and adenocarcinoma of the cervix (AC) in women treated with CO2-laser conization for cervical intraepithelial neoplasia (CIN) or squamocellular cervical cancer (SCC). The medical records of all women with a histological diagnosis of squamous lesions of the uterine cervix (persistent CIN1, CIN2, CIN3 and SCC) who were subsequently treated with CO2-laser conization at our institution, during the period from January 1991 to December 2014, were analyzed in a retrospective case series...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28213874/disease-burden-of-human-papillomavirus-infection-in-the-netherlands-1989-2014-the-gap-between-females-and-males-is-diminishing
#5
Scott A McDonald, Venetia Qendri, Johannes Berkhof, Hester E de Melker, Johannes A Bogaards
PURPOSE: Besides cervical cancer, HPV infection is linked to a multitude of diseases in both males and females, suggesting that vaccination programmes should be re-evaluated, with a judicious assessment made of the disease burden stratified by sex, age, and genotype. Projections of burden into the near future are also needed to provide a benchmark for evaluating the impact of vaccination programmes, and to assess the need for scaling-up preventive measures. METHODS: Using the disability-adjusted life-years (DALY) measure, we estimated the total HPV-associated disease burden in the Netherlands...
March 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28212672/cytokeratin7-and-cytokeratin19-expression-in-high-grade-cervical-intraepithelial-neoplasm-and-squamous-cell-carcinoma-and-their-possible-association-in-cervical-carcinogenesis
#6
Hojung Lee, Hyekyung Lee, Yong Kyun Cho
BACKGROUND: High risk human papillomavirus (HR HPV) infects cells at the squamocolumnar junction (SCJ) of the cervix, causing cancer. Cytokeratin (CK)7 is an SCJ marker, and stains cervical neoplasia. CK19 is a binding partner of CK7 and expressed in cervical cancer. Despite this possible association between CK7/CK19 and cervical cancer, not much is known about the mechanism of CK7/CK19 involvement in HR HPV-mediated cervical carcinogenesis. METHODS: We analyzed the expression pattern of CK7, CK19, and p16 by using immunohistochemistry and HPV infection by in situ hybridization in 25 cases of high grade cervical intraepithelial neoplasia (CIN3) and in 30 cases of squamous cell carcinoma (SCC)...
February 17, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28196844/cervical-cancer-incidence-after-normal-cytological-sample-in-routine-screening-using-surepath-thinprep-and-conventional-cytology-population-based-study
#7
Kirsten Rozemeijer, Steffie K Naber, Corine Penning, Lucy I H Overbeek, Caspar W N Looman, Inge M C M de Kok, Suzette M Matthijsse, Matejka Rebolj, Folkert J van Kemenade, Marjolein van Ballegooijen
Objective To compare the cumulative incidence of cervical cancer diagnosed within 72 months after a normal screening sample between conventional cytology and liquid based cytology tests SurePath and ThinPrep.Design Retrospective population based cohort study.Setting Nationwide network and registry of histo- and cytopathology in the Netherlands (PALGA), January 2000 to March 2013.Population Women with 5 924 474 normal screening samples (23 833 123 person years).Exposure Use of SurePath or ThinPrep versus conventional cytology as screening test...
February 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28181670/risk-of-persistent-or-recurrent-neoplasia-in-conservatively-treated-women-with-cervical-adenocarcinoma-in-situ-with-negative-histological-margins
#8
Aime Munro, Jim Codde, Katrina Spilsbury, Colin J R Stewart, Nerida Steel, Yee Leung, Jason Tan, Stuart G Salfinger, Ganendra R Mohan, James B Semmens, Paul A Cohen
INTRODUCTION: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of adenocarcinoma-in-situ (AIS) are uncertain. This study aims to investigate the risk of persistent or recurrent cervical neoplasia (AIS, adenocarcinoma and/or high-grade cervical squamous intraepithelial neoplasia (CIN)) and compliance with follow-up recommendations in conservatively treated women with AIS and negative histopathological margins...
February 9, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28181356/cd40-polymorphism-in-cervical-carcinoma-in-a-subset-of-malaysian-population
#9
Purushotham Krishnappa, Hong Mun Kong, Ibtisam Binti Mohamad, Kenny Voon, Sushela Devi Somanath
AIM: The aim of this study was to determine the allelic frequency of single nucleotide polymorphisms (SNPs) in the human CD40 gene in cervical cancer. METHODS: A total of 200 cases were selected from the records of the Department of Pathology, Hospital Tuanku Jaafar, Seremban, Malaysia. The samples were collected in three separate groups: cervicitis (n = 61), cervical intraepithelial neoplasia (n = 69), and cervical carcinoma (n = 70). The patients' demographic data and the respective paraffin-embedded tissue samples from Hospital Tuanku Jaafar, Seremban were obtained upon consent...
February 8, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28170083/detection-of-cervical-intraepithelial-neoplasia-with-hpve6-e7-mrna-among-women-with-atypical-squamous-cells-of-unknown-significance
#10
Ya Li, Shouhua Rong, Yanfang Zhi, Cui Qiu, Tingting Fan, Xiaofu Li
OBJECTIVE: To compare E6/E7 mRNA and HPV DNA assays for evaluating women with atypical cells of undetermined significance (ASCUS). METHODS: The present prospective study enrolled patients with ASCUS undergoing HPV testing at Third Affiliated Hospital of Zhengzhou University, China, between September 1, 2013, and January 31, 2016. Patients with positive HPV DNA test results underwent screening by E6/E7 mRNA assay, and the accuracy of HPV DNA and E6/E7 mRNA testing were compared, with histology used for definitive diagnoses...
February 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28168772/evaluation-of-endocervical-curettage-with-conization-in-diagnosis-of-endocervical-lesions
#11
Yukio Suzuki, Tamaki Cho, Tae Mogami, Naho Ruiz Yokota, Tatsuya Matsunaga, Mikiko Asai-Sato, Fumiki Hirahara, Masanori Nojima, Mitsuru Mori, Etsuko Miyagi
AIM: Endocervical curettage (ECC) at the time of conization has been reported to be effective for diagnosing cervical intraepithelial neoplasia and/or early stage cervical cancer. We aimed to verify the accuracy of ECC with conization. METHODS: We retrospectively analyzed the records of 540 patients with suspected neoplastic cervical lesions who underwent conization at the Yokohama City University Hospital from January 2008 to December 2015. To validate the effectiveness of ECC for evaluating endocervical lesions, histopathologic findings from ECC samples were compared with those from endocervical specimens obtained by conization...
February 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28166181/dna-vaccine-encoding-hpv16-oncogenes-e6-and-e7-induces-potent-cell-mediated-and-humoral-immunity-which-protects-in-tumor-challenge-and-drives-e7-expressing-skin-graft-rejection
#12
Janin Chandra, Julie L Dutton, Bo Li, Wai-Ping Woo, Yan Xu, Lynn K Tolley, Michelle Yong, James W Wells, Graham R Leggatt, Neil Finlayson, Ian H Frazer
We have previously shown that a novel DNA vaccine technology of codon optimization and the addition of ubiquitin sequences enhanced immunogenicity of a herpes simplex virus 2 polynucleotide vaccine in mice, and induced cell-mediated immunity when administered in humans at relatively low doses of naked DNA. We here show that a new polynucleotide vaccine using the same technology and encoding a fusion protein of the E6 and E7 oncogenes of high-risk human papillomavirus type 16 (HPV16) is immunogenic in mice. This vaccine induces long-lasting humoral and cell-mediated immunity and protects mice from establishment of HPV16-E7-expressing tumors...
February 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28161543/anal-study-in-immunocompetent-women-with-human-papillomavirus-related-lower-genital-tract-pathology
#13
Concepción Donaire, Marcos Reillo, Juan C Martínez-Escoriza, José A López-Fernández
OBJETIVE: To estimate the prevalence of anal dysplasia in immunocompetent women with cervical intraepithelial dysplasia. STUDY DESIGN: We did a prospective cohort study, in which we enrolled 166 women with gynecological pathology related to human papilloma virus (HPV) infection. All patients underwent an anal cytology and HPV detection. Statistical analysis with a 95% confidence interval was used for prevalence calculations. A Χ2 test and Fisher's exact one were used to determine differences between groups of qualitative variables...
January 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28158224/development-of-a-simple-and-quick-immunochromatography-method-for-detection-of-anti-hpv-16-18-antibodies
#14
Fumiko Endo, Tsutomu Tabata, Daichi Sadato, Machiko Kawamura, Noriyuki Ando, Keisuke Oboki, Masako Ukaji, Kaoru Kobayashi, Yukuharu Kobayashi, Tomoaki Ikeda, Futoshi Shibasaki
Immunochromatography (IC) is widely used to detect target molecules in biological fluids. Since this method can be performed without a special technique or device, IC is a convenient way to assess the existence of antibodies or pathogens such as viruses and bacteria, simply and quickly. In this study, we established an IC method to detect serum antibodies against oncogenic human papillomavirus (HPV)-16 and HPV-18 L1 proteins using recombinant L1 proteins produced by silkworms as antigens. Infection of oncogenic HPVs is a major risk factor of cervical cancer, which is one of the most common cancers in women worldwide...
2017: PloS One
https://www.readbyqxmd.com/read/28157250/the-incidence-of-cervical-intraepithelial-neoplasia-in-a-population-of-pregnant-women-with-an-abnormal-cytology
#15
Dominik Pruski, Blanka Malkowska-Walczak, Aleksandra Paluszkiewicz, Witold Kędzia
OBJECTIVES: To assess the incidence of cervical intraepithelial neoplasia - SIL and cervical cancer in a population of pregnant women with an abnormal cytology. MATERIAL AND METHODS: In pregnant women with abnormal cytology results according to The Bethesda System, a verifying diagnostics was carried out, including colposcopy and cervical biopsy. RESULTS: The most common histological and oncologic diagnosis in the whole study group of pregnant women were HGSIL changes, covering cervical intraepithelial neoplasia of medium and high grade - CIN 2 and CIN 3...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28143439/human-papillomavirus-infections-among-women-with-cervical-lesions-and-cervical-cancer-in-eastern-china-genotype-specific-prevalence-and-attribution
#16
Lei Zhang, Qingqing Bi, Hua Deng, Jing Xu, Juan Chen, Meilian Zhang, Xiaofeng Mu
BACKGROUND: Cervical cancer and its precursor, high-grade cervical intraepithelial neoplasia (CIN2/3), are associated with persistent high-risk human papillomavirus (HPV) infection. HPV genotype prevalence varies with severity of cervical lesions, patient age and geographical location. The aim of this study was to investigate HPV genotypes prevalence and attribution according to the severity of cervical lesions among Chinese women. METHOD: A 4-year surveillance study was performed...
January 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28138695/involvement-of-retinoblastoma-associated-protein%C3%A2-48-during-photodynamic-therapy-of-cervical-cancer-cells
#17
Shuxia Wu, Lijun Wang, Xingye Ren, Yulu Pan, Yan Peng, Xiaoyan Zou, Cuige Shi, Youzhong Zhang
5-Aminolevulinic acid-mediated photodynamic therapy (ALA‑PDT) is an effective treatment option for cervical intraepithelial neoplasia, the precancerous lesion of cervical cancer, and early cervical cancer, particularly for young or nulliparous women who want to remain fertile. A previous report described the involvement of histone deacetylases (HDAC) during ALA‑PDT mediated apoptosis in the cerebral cortex of a mouse model. Retinoblastoma‑associated protein 48 (RbAp48), a highly abundant component of HDACs, is a critical mediator that controls the transforming activity of human papillomavirus 16 in cervical cancer cells...
January 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28138337/human-papillomavirus-genotypes-associated-with-cervical-precancerous-lesions-and-cancer-in-the-highest-area-of-cervical-cancer-mortality-longnan-china
#18
Jin Zhao, Zhong Guo, Qiang Wang, Tianbin Si, Shuyan Pei, Chenjing Wang, Hongmei Qu, Jianbin Zhong, Ying Ma, Cong Nie, Dan Zhang
BACKGROUND: The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China. METHODS: Between 2012 to 2016, 329 samples with cervicitis, cervical intraepithelial neoplasia grade 1 to 3 (CINI to III), and invasive squamous cell carcinoma (SCC) were collected. HPV genotypes were examined with a validated kit for 23 different HPV subtypes. RESULTS: Compared to cervicitis, the HPV positivity is significantly higher in CINI, CIN II/III, and SCC (38...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28129439/age-related-changes-in-pre-and-post-conization-hpv-genotype-distribution-among-women-with-high-grade-cervical-intraepithelial-neoplasia
#19
Luca Giannella, Cristina Fodero, Fausto Boselli, Teresa Rubino, Kabala Mfuta, Sonia Prandi
OBJECTIVE: To assess the effect of age on pre- and post-conization HPV genotype distribution. METHOD: The present retrospective observational study included consecutive women with high-grade cervical intraepithelial neoplasia who underwent conization at the Cervical Cancer Screening Centre of Reggio Emilia, Italy, and University Hospital of Modena, Italy, between February 1, 2012, and October 31, 2014. Pre-conization and 6-month post-conization HPV genotyping results were compared between four age groups (<30, 30-39, 40-49, and ≥50 years) and age-related changes in the HPV genotypes present were evaluated...
January 27, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28124442/patterns-of-persistent-hpv-infection-after-treatment-for-cervical-intraepithelial-neoplasia-cin-a-systematic-review
#20
REVIEW
Sarah R Hoffman, Tam Le, Alexandre Lockhart, Ayodeji Sanusi, Leila Dal Santo, Meagan Davis, Dana A McKinney, Meagan Brown, Charles Poole, Corinne Willame, Jennifer S Smith
No abstract text is available yet for this article.
January 25, 2017: International Journal of Cancer. Journal International du Cancer
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