keyword
MENU ▼
Read by QxMD icon Read
search

Cervical intraepithelial neoplasia

keyword
https://www.readbyqxmd.com/read/28723743/analysis-of-hpv-distribution-in-patients-with-cervical-precancerous-lesions-in-western-china
#1
Kemin Li, Rutie Yin, Qingli Li, Danqing Wang
Cervical human papillomavirus (HPV) infection is a dangerous disease, whose subtypes exhibit different distribution patterns in particular countries, regions, and races. In this study, the HPV distribution in patients with cervical precancerous lesions in Western China was investigated to assess a probability for prevention of cervical cancer and the clinical application of an HPV vaccine in China. The retrospective study of patients with different HPV subtypes and cervical precancerous lesions, who have undergone loop eelectrosurgical excision procedure, cold knife conization, or a total hysterectomy in our hospital from January 2016 to August 2016, was performed...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28720454/comparative-accuracy-of-pap-smear-and-hpv-screening-in-ubon-ratchathani-in-thailand
#2
Suleeporn Sangrajrang, Piyawat Laowahutanont, Metee Wongsena, Richard Muwonge, Anant Karalak, Weerawut Imsamran, Virginia Senkomago, Rengaswamy Sankaranarayanan
We evaluate the potential for using high-risk human papillomavirus (hr-HPV) testing-based screening for cervical intraepithelial neoplasia (CIN) in routine health services in Thailand; its accuracy in comparison to that of conventional cytology (CC); and the utility of HPV16/18 positive results and liquid-based cytology (LBC) triage for HPV-positive women in the detection of high-grade CIN. Women aged 30-60 years in Ubon Ratchathani province, Thailand were screened with CC and hr-HPV testing and those abnormal on either tests were referred for colposcopy and/or directed biopsies...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720450/detection-of-cervical-precancerous-lesions-with-aptima-hpv-assays-using-surepath-preservative-fluid-specimens
#3
Max Chernesky, Dan Jang, Nick Escott, Jodi Gilchrist, Jenny Li, Laurie Elit, Alice Lytwyn, Marek Smieja, Sam Ratnam, Manuel Arias, Damon Getman, Barbara Weinbaum, Brett Kirkconnell, Janel Dockter
SurePath specimens from women referred to colposcopy were treated with Aptima Transfer Solution (ATS) before testing in Aptima HPV (AHPV) and Aptima HPV 16, 18/45 (AHPV-GT) assays. Untreated SurePath specimens were tested with the cobas HPV test. PreservCyt specimens were assessed for cytology and tested with AHPV. High-grade cervical intraepithelial neoplasia lesions served as the reference standard. Excellent agreement (95.5%; k=0.91) was observed for ATS-treated SurePath specimens between Tigris and Panther systems and between the PreservCyt and ATS-treated SurePath specimens (91...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28717723/cervical-abnormalities-in-south-african-women-living-with-hiv-with-high-screening-and-referral-rates
#4
Ingrid T Katz, Lisa M Butler, Tamaryn L Crankshaw, Alexi A Wright, Karen Bramhill, Dominick A Leone, Janet Giddy, Sean Mould
PURPOSE: To determine the prevalence of screening, cervical dysplasia, and malignancy on the basis of histologic diagnoses from colposcopy and large loop excision of the transformation zone among women living with HIV (WLWH) who attended an urban antiretroviral treatment (ART) clinic in KwaZulu-Natal, South Africa. MATERIALS AND METHODS: We performed a retrospective cohort study to examine a random sample of 462 WLWH during a 5-year period from 2004 to 2009. Women on ART for < 3 months were excluded...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716490/-self-evaluation-of-conization-indications-since-the-introduction-of-the-french-colposcopy-and-cervico-vaginal-pathology-quality-charter-in-2%C3%A2-colposcopy-centers
#5
M Lallemant, C Baeza, C Monnin, M Malincenco, C Gay
OBJECTIVES: Analyze the efficiency of the implementation of the colposcopy and cervico-vaginal pathology quality charter. The question was to determine whether the criteria of more than 70% of excisional conizations containing CIN2+ lesions (cervical intraepithelial neoplasia 2 or 3 or carcinoma in situ) had been reached and demonstrate a reduction of the conization rate is possible. METHODS: An epidemiological descriptive, retrospective and multicenter study was performed in "Nord Franche-Comté Hospitals" (Belfort and Montbéliard, France) during the period from November 2013 to January 2015...
July 14, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28705710/using-p16-immunohistochemistry-to-classify-morphologic-cervical-intraepithelial-neoplasia-2-correlation-of-ambiguous-staining-patterns-with-hpv-subtypes-and-clinical-outcome
#6
Yuxin Liu, Mahfood Alqatari, Kieran Sultan, Fei Ye, Dana Gao, Keith Sigel, David Zhang, Tamara Kalir
P16(INK4a) immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. While most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It is unclear whether ambiguous p16 immunoreactivity indicates oncogenic HPV infection or risk of progression. Herein, we compared HPV genotypes and subsequent High-grade Squamous Intraepithelial Lesion (HSIL) outcomes among 220 cervical biopsies with a differential diagnosis of Cervical Intraepithelial Neoplasia 2 (CIN 2) based on hematoxylin and eosin morphology and varying degrees of p16 immunoreactivity...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28697900/the-distribution-of-human-papillomavirus-genotypes-in-cervical-cancer-and-intraepithelial-neoplasia-lesions-among-chinese-women-in-yunnan-province
#7
Li Yuanyue, Zulqarnain Baloch, Nafeesa Yasmeen, Yuan Tao, Wu Xiaomei, Xia Xueshan
This study was designed to explore baseline data about the prevalence and distribution of human papillomavirus (HPV) genotypes among Chinese women who had cervical intraepithelial lesions and cervical cancer. A total of 511 patients were recruited, and biopsy samples were collected from these patients. Polymerase chain reaction was used to detect HPV-positive samples, and the HPV GenoArray kit was used for genotyping. A total of 23 genotypes were detected, including 13 that were high risk-HPV (HR-HPV), 3 that were potential high risk-HPV (PHR-HPV) and 7 that were low risk-HPV (LR-HPV)...
July 8, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28693176/flexible-magnifying-endoscopy-with-narrow-band-imaging-for-the-diagnosis-of-uterine-cervical-tumors-a-cooperative-study-among-gastrointestinal-endoscopists-and-gynecologists-to-explore-a-novel-microvascular-classification-system
#8
Noriko Nishiyama, Kenji Kanenishi, Hirohito Mori, Hideki Kobara, Shintaro Fujihara, Taiga Chiyo, Nobuya Kobayashi, Tae Matsunaga, Maki Ayaki, Tatsuo Yachida, Ayako Fujimori, Makoto Oryu, Chiaki Tenkumo, Megumi Ishibashi, Uiko Hanaoka, Toshiyuki Hata, Yumi Miyai, Kyuichi Kadota, Reiji Haba, Tsutomu Masaki
Narrow band imaging with magnifying endoscopy (NBI-ME), which is useful for the assessment of micro-vessels, has excellent diagnostic potential for early gastrointestinal epithelial neoplasia. Conventional diagnostic tools for uterine cervical epithelial tumors are still unsatisfactory. An accurate diagnostic tool for uterine cervical epithelial tumors is required to preserve the reproductive ability of young women with uterine cervical tumors. Flexible NBI-ME was performed in patients with cervical squamous cell lesions that required further examinations based on their Pap smear results (cytology ≥ low-grade squamous intraepithelial lesion) at Kagawa University Hospital between April 2014 and April 2015...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693008/two-landmark-studies-published-in-1976-1977-paved-the-way-for-the-recognition-of-human-papillomavirus-as-the-major-cause-of-the-global-cancer-burden
#9
Kari J Syrjänen
Two groundbreaking reports were published in Acta Cytologica at the transition of 1976 to 1977. One appeared in the last issue of 1976 [Meisels and Fortin: Acta Cytol 1976;20:505-509] and the other in the first issue of 1977 [Purola and Savia: Acta Cytol 1977;21:26-31]. Today, 40 years later, it is not an overstatement to conclude that these are the two most influential studies ever published in this journal. Two reports with a similar content being published so close together (in the same journal) raised the question "Which of the two reports was truly submitted first?" In this commentary, this enigma is clarified beyond reasonable doubt, based on the well-considered testimonial of Prof...
July 11, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28692545/selection-of-women-at-risk-for-cervical-cancer-in-an-hiv-infected-south-african-population
#10
Marjolein Van Zummeren, Wieke W Kremer, Matthys C Van Aardt, Erika Breytenbach, Karin L Richter, Lawrence Rozendaal, Birgit I Witte, Lise M A de Strooper, Albertus T Hesselink, Daniëlle A M Heideman, Peter J F Snijders, Renske D M Steenbergen, Greta Dreyer, Chris J L M Meijer
OBJECTIVE: Cervical cancer is the leading cause of cancer-related death in women in South Africa. This study evaluates DNA methylation levels in cervical (pre)cancer and aims to assess the value of high-risk human papillomavirus (hrHPV) testing and methylation analysis, alone or in combination, on physician-taken cervical scrapes to detect cervical cancer, and cervical intraepithelial neoplasia grade 3 (CIN3) in an HIV-infected South African population. DESIGN: Prospective observational multi-centre cohort study...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28691644/distribution-and-attribution-of-high-risk-human-papillomavirus-genotypes-in-cervical-precancerous-lesions-in-china
#11
Wenpeng Wang, Jusheng An, Yan Song, Minjie Wang, Manni Huang, Lingying Wu
While human papillomavirus vaccine was recently approved by China Food and Drug Administration, mapping of high-risk human papillomavirus distribution and attribution in cervical precancerous lesions in China becomes critical in development of a high-risk human papillomavirus-based cervical cancer screening and prevention strategy. In total, 1016 patients with cervical precancerous lesions diagnosed in the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences were analyzed retrospectively, including 111 patients with low-grade squamous intraepithelial lesions and 905 patients with high-grade squamous intraepithelial lesions...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28678394/risk-of-persistent-or-recurrent-cervical-neoplasia-in-patients-with-pure-adenocarcinoma-in-situ-ais-or-mixed-ais-and-high-grade-cervical-squamous-neoplasia-cervical-intraepithelial-neoplasia-grades-2-and-3-cin-2-3-a-population-based-study
#12
Elizabeth Codde, Aime Munro, Colin J R Stewart, Katrina Spilsbury, Shirley Bowen, Jim Codde, Nerida Steel, Yee Leung, Jason Tan, Stuart G Salfinger, Ganendra R Mohan, Paul A Cohen
OBJECTIVE: To compare outcomes of patients with pure AIS and mixed AIS/CIN 2/3 lesions including the incidence of AIS persistence, recurrence and progression to adenocarcinoma. DESIGN: Retrospective cohort study. SETTING: Statewide population in Western Australia. POPULATION: Women diagnosed with AIS between 2001 and 2012. METHODS: We conducted a retrospective, population-based cohort study. MAIN OUTCOME MEASURES: De-identified linked data were utilized to ascertain the association between patient age at excisional treatment, margin status, lesion type, lesion size, and risk of persistent AIS (defined as the presence of AIS <12 months from treatment), recurrent AIS (≥12 months post treatment), and adenocarcinoma...
July 5, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28675291/efficacy-of-carboxymethyl-beta-glucan-in-cervical-intraepithelial-neoplasia-a-retrospective-case-control-study
#13
Patrizia Stentella, Alberto Biamonti, Carlo Carraro, Paolo Inghirami, Pasquale Mancino, Daniela Pietrangeli, Sergio Votano, Paola Lazzari, Caterina DE Medici
BACKGROUND: Persistent human papillomavirus (HPV) infection constitutes the principal risk factor for the development of cervical intraepithelial neoplasia (CIN) and cervical cancer. For this reason, new drugs have been studied to support the host immune system against the HPV infection. The aim of this retrospective, case-control study was to detect the efficacy and safety of carboxymethyl β-glucan (Colpofix®) gel as adjuvant therapy in HPV infection. METHODS: The medical records of patients attending the Colposcopy Service of four hospitals in Rome from 2011 to 2013 were collected...
October 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28670823/stratifying-hpv-positive-women-for-cin3-risk-after-one-and-two-rounds-of-hpv-based-screening
#14
Nienke J Veldhuijzen, Nicole J Polman, Peter J F Snijders, Chris J L M Meijer, Johannes Berkhof
A main challenge of human papilloma (HPV)-based screening for cervical cancer is to adequately identify HPV-positive women at highest risk of cervical intraepithelial neoplasia grade 3 or worse, CIN3+. The prognostic value of currently used adjunct markers (HPV16/18 genotyping and reflex cytology) may change after multiple rounds of HPV-based screening because of a change in the proportion of HPV-positive women with incident infections. To this end, we re-analyzed results from the POBASCAM trial (Population Based Screening Study Amsterdam)...
July 3, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28669173/flow-cytometric-analysis-of-dna-ploidy-in-liquid-based-cytology-for-cervical-pre-cancer-and-cancer
#15
Sridhar Mishra, Namrata P Awasthi, Nuzhat Husain, Akansha Anand, Yashodhara Pradeep, Roohi Ansari, Sarita Saxena
Background: DNA ploidy analysis of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer samples by flow cytometry (FCM) has been established as an aid to prognostic assessment. Liquid based cytology (LBC) increases diagnostic specificity by using ancillary techniques that provide information beyond morphology. The present study was undertaken to assess DNA ploidy in LBC samples as an adjunct for early detection of cervical pre-cancer and cancer. Methods: DNA ploidy assessment was performed on LBC samples of 50 cases and 31 controls...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28658331/evaluation-of-telomerase-htert-ki67-and-p16ink4a-expressions-in-low-and-high-grade-cervical-intraepithelial-lesions
#16
Ana Paula Szezepaniak Goulart, Manoel Afonso Guimarães Gonçalves, Vinicius Duval DA-Silva
Objective : to study the association between the histological grading of cervical intraepithelial neoplasia (CIN I, CIN II and CIN III) and the immunohistochemical expression for p16ink4a, hTert and Ki67, as well as to evaluate the relationship of these markers with the risk of recurrence after surgical treatment. Methods : we studied a historical cohort of 94 women with intraepithelial lesions CIN I (low grade), CIN II and CIN III (high grades) submitted to conization or electrosurgical excision of the transformation zone...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28657227/prospective-comparison-of-hybrid-capture-2-and-spf%C3%A2-%C3%A2-lipa-for-carcinogenic-human-papillomavirus-detection-and-risk-prediction-of-cervical-cancer-a-population-based-cohort-study-in-china
#17
Li Dong, Rui Mei Feng, Li Zhang, Xiao Qian Xu, Xue Lian Zhao, Margaret Zhuoer Wang, You Lin Qiao, Fang Hui Zhao
OBJECTIVE: To investigate the extent of the cross-reactivity of hybrid capture 2 (HC2) assay and evaluate the potential effect of cross-reactivity on the long-term risk for cervical cancer and precancers. METHODS: Based on the Shanxi Province Cervical Cancer Screening Study-I (SPOCCS-I) cohort from 2005 to 2014 in Shanxi, China, SPF10-line probe assay (LiPA) was performed in all 598 HC2 positive and 300 random-selected HC2 negative cervical specimens. Ten-year cumulative incidence rate (CIR) of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) of these two tests was evaluated using Kaplan-Meier methods...
June 5, 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28657217/role-of-active-and-passive-smoking-in-high-risk-human-papillomavirus-infection-and-cervical-intraepithelial-neoplasia-grade-2-or-worse
#18
Rui Mei Feng, Shang Ying Hu, Fang Hui Zhao, Rong Zhang, Xun Zhang, Asya Izraelit Wallach, You Lin Qiao
OBJECTIVE: We performed a pooled analysis to examine cigarette smoking and household passive smoke exposure in relation to the risk of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia grade 2+ (CIN2+). METHODS: Data were pooled from 12 cross-sectional studies for cervical cancer screenings from 10 provinces of China in 1999-2007. A total of 16,422 women were analyzed, along with 2,392 high-risk-HPV (hr-HPV) positive women and 381 CIN2+ cases...
March 24, 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28656100/efficacy-of-human-papillomavirus-l1-protein-vaccines-cervarix-and-gardasil-in-reducing-the-risk-of-cervical-intraepithelial-neoplasia-a-meta-analysis
#19
REVIEW
Mohammad Reza Haghshenas, Tahoora Mousavi, Motahareh Kheradmand, Mahdi Afshari, Mahmood Moosazadeh
Human papillomavirus (HPV) can induce cervical intraepithelial neoplasia (CIN). Vaccination against HPV can play an important role in CIN prevention. This study aims to estimate the efficacy of L1 protein vaccines (Cervarix and Gardasil) in CIN 1, 2, 3 risk reduction using meta-analysis. Relevant articles were identified by two independent researchers searching international databanks. After application of inclusion/exclusion criteria and quality assessment, eligible articles were entered into the final meta-analysis...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28655061/outcomes-in-women-with-cytology-showing-atypical-squamous-cells-of-undetermined-significance-with-vs-without-human-papillomavirus-testing
#20
Jack Cuzick, Orrin Myers, Ji-Hyun Lee, Yang Shi, Julia C Gage, William C Hunt, Michael Robertson, Cosette M Wheeler
Importance: Little is known about the long-term yield of high-grade cervical intraepithelial neoplasia (CIN) and the influence on biopsy and treatment rates of human papillomavirus (HPV) triage of cytology showing atypical squamous cells of undetermined significance (hereafter ASC-US cytology). Objective: To examine 5-year outcomes after ASC-US cytology with vs without HPV testing. Design, Setting, and Participants: In this observational study, all cervical cytology and HPV testing reports from January 1, 2007, to December 31, 2012, were obtained for women throughout New Mexico and linked to pathology reports...
June 22, 2017: JAMA Oncology
keyword
keyword
116378
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"