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Cervical intraepithelial neoplasia

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https://www.readbyqxmd.com/read/28812024/influence-of-human-papillomavirus-infection-on-the-natural-history-of-cervical-intraepithelial-neoplasia-1-a-meta-analysis
#1
REVIEW
Mingzhu Liu, Xiaolong Yan, Mei Zhang, Xiaoju Li, Shugang Li, Mingxia Jing
OBJECTIVE: To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. METHODS: Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811980/erap1-overexpression-in-hpv-induced-malignancies-a-possible-novel-immune-evasion-mechanism
#2
Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K Grabowska, Angelika B Riemer
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. To date, the APM had not been studied systematically in a large array of HPV(+) tumor samples. Therefore in this study, systematic expression analysis of the APM was performed on the mRNA and protein level in a comprehensive collection of HPV16(+) cell lines...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28807346/application-of-a-time-resolved-fluoroimmunoassay-for-detection-of-p16ink4a-in-cervix
#3
Li Ding, Qiong Chen, Wanting Fan, Xianjin Zou
OBJECTIVE: To establish a time-resolved fluoroimmunoassay (TRFIA) method to detect p16INK4a. METHODS: 119 cases of exfoliative cells following Thinprep cytologic test (TCT) test were selected for TRFIA and biopsy tissues of these patients according to TCT results were collected for immunohistochemical (IHC) staining. RESULTS: There were 40 cases with cervicitis, 16 cases of cervical intraepithelial neoplasia grade 1 (CIN1), 15 cases of CIN2, 26 cases of CIN3, and 22 cases of squamous cell carcinoma (SCC)...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28797154/-to-analyse-the-histopathological-results-of-patients-with-hpv16-18-positive-and-colposcopic-suspicious-lesions
#4
J X Zhang, T P Zheng, J Liu, Q X Wang, Y X Zhan, Z Y Zhang
Objective: To explore the value of histopathologic diagnosis after colposcopy for high-risk HPV16/18 positive patients with negative cytology or atypical squamous cells of undetermined significance (ASCUS) for early screening of cervical lesions. Methods: A retrospective study of cervical histopathologic diagnosis in the HPV16/18 positive patients received colposcopy evaluation before got the histology was carried out between January 2014 and January 2016. The cytology of the patients should be negative or ASCUS...
July 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28796882/cytology-versus-hpv-testing-for-cervical-cancer-screening-in-the-general-population
#5
REVIEW
George Koliopoulos, Victoria N Nyaga, Nancy Santesso, Andrew Bryant, Pierre Pl Martin-Hirsch, Reem A Mustafa, Holger Schünemann, Evangelos Paraskevaidis, Marc Arbyn
BACKGROUND: Cervical cancer screening has traditionally been based on cervical cytology. Given the aetiological relationship between human papillomavirus (HPV) infection and cervical carcinogenesis, HPV testing has been proposed as an alternative screening test. OBJECTIVES: To determine the diagnostic accuracy of HPV testing for detecting histologically confirmed cervical intraepithelial neoplasias (CIN) of grade 2 or worse (CIN 2+), including adenocarcinoma in situ, in women participating in primary cervical cancer screening; and how it compares to the accuracy of cytological testing (liquid-based and conventional) at various thresholds...
August 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28795241/papillomavirus-genotyping-on-formaldehyde-fixed-paraffin-embedded-tissues-in-vulvar-intraepithelial-neoplasia
#6
S Mazellier, B Dadone-Montaudie, A Chevallier, C Loubatier, S Vitale, N Cardot-Leccia, K Angeli, C Trastour, J Delotte, V Giordanengo, D Ambrosetti
PURPOSE: Few studies have described the epidemiology of human papillomavirus (HPV) in vulvar intraepithelial neoplasia (VIN). The aim of this study was to genotype HPV on formalin fixed paraffin-embedded tissues in VIN lesions. METHODS: A 5-year retrospective study was conducted by including all patients attending the teaching hospital of Nice with a diagnosis of VIN between 1st January 2010 and 31st December 2014. For all patients, HPV genotyping was performed with the PapilloCheck(®) microarray kit, routinely used on cervical cytology samples, and optimized for formaldehyde fixed paraffin-embedded tissues in VIN...
August 9, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28791267/atypical-squamous-cells-of-undetermined-significance-and-low-grade-squamous-intraepithelial-lesion-triage-in-korean-women-revisiting-the-2012-american-society-of-colposcopy-and-cervical-pathology-screening-guidelines
#7
Ji Yeon Hyun, Kyung-Jin Min, Sun Young Yang, Jae-Kwan Lee, Jin Hwa Hong
OBJECTIVE: To determine whether triage for atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) from the updated American Society for Colposcopy and Cervical Pathology cervical cancer screening guidelines is applicable in Korean women. METHODS: We investigated women with ASC-US or LSIL including referred from local hospitals visited for cervical cancer screening at Korea University Guro Hospital from February 2004 to December 2014...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28780541/associations-between-highly-active-antiretroviral-therapy-and-the-presence-of-hpv-premalignant-and-malignant-cervical-lesions-in-sub-saharan-africa-a-systematic-review-current-evidence-and-directions-for-future-research
#8
Sonia Menon, Rodolfo Rossi, Natasha Zdraveska, Mbabazi Kariisa, Sushama D Acharya, Davy Vanden Broeck, Steven Callens
OBJECTIVES: In sub-Saharan Africa, substantial international funding along with evidence-based clinical practice have resulted in an unparalleled scale-up of access to antiretroviral treatment at a higher CD4 count. The role and timing of highly active antiretroviral therapy (HAART) in mediating cervical disease remains unclear. The aim of this article is to systematically review all evidence pertaining to Africa and identify research gaps regarding the epidemiological association between HAART use and the presence of premalignant/malignant cervical lesions...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28774281/frequency-of-human-papillomavirus-in-women-attending-cervical-cancer-screening-program-in-chile
#9
Priscilla Brebi, Carmen Gloria Ili, Alejandra Andana, Doris Menzel, Jaime Lopez, Pablo Guzman, Angelica Melo, Kurt Buchegger, Juan C Roa
BACKGROUND: Human papillomavirus (HPV) is the etiological factor for cervical cancer and its precursor lesions. The characterization of HPV genotypes in preneoplastic lesions and cervical cancer could establishes the effectiveness of vaccination plan in Chilean population. The aim of this study was to determine HPV frequency in a group of women including in a cervical screening program in the public health care system in Chile. METHODS: We analyzed 985 cervical smears samples from women with different histological diagnosis, attending to public health care in Temuco-Chile between 2004 and 2012, to detect HPV genotypes, through PCR followed by reverse line blotting assay...
August 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28767912/translation-and-cultural-adaptation-of-the-functional-assessment-of-chronic-illness-therapy-cervical-dysplasia-facit-cd-to-evaluate-quality-of-life-in-women-with-cervical-intraepithelial-neoplasia
#10
Cristiane Menezes Sirna Fregnani, José Humberto Tavares Guerreiro Fregnani, Carlos Eduardo Paiva, Eliane Marçon Barroso, Mayara Goulart de Camargos, Audrey Tieko Tsunoda, Adhemar Longatto-Filho, Bianca Sakamoto Ribeiro Paiva
Objective: To translate and perform the cultural adaptation of the tool Functional Assessment of Chronic Illness Therapy - Cervical Dysplasia (FACIT-CD) to the Portuguese language. Methods: A descriptive cross-sectional study, with translation and cultural adaptation of the assessment tool performed according to international guidelines and the Functional Assessment of Chronic Illness Therapy (FACIT) protocol group. It involved eight experts, six from Brazil, one from Portugal and one from the United States...
April 2017: Einstein
https://www.readbyqxmd.com/read/28765084/surveillance-of-high-grade-cervical-cancer-precursors-cin-iii-ais-in-four-population-based-cancer-registries-united-states-2009-2012
#11
Meg Watson, Ashwini Soman, Elaine W Flagg, Elizabeth Unger, Dennis Deapen, Vivien W Chen, Lauren C Peres, Glenn Copeland, Thomas C Tucker, Erin Garnett, Mona Saraiya
Surveillance of cervical intraepithelial neoplasia grade III (CIN III) and adenocarcinoma in situ (AIS) is important for determining the burden of a preventable disease, identifying effects of vaccination on future diagnoses, and developing targeted programs. We analyzed population-based rates of high-grade cervical cancer precursor lesions using data from four central cancer registries (diagnosis years 2009-2012 from Louisiana, Kentucky, Michigan, and diagnosis years 2011-2012 from Los Angeles) by age, race, and histology...
July 29, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28759170/is-oral-contraceptive-use-associated-with-an-increased-risk-of-cervical-cancer-an-evidence-based-meta-analysis
#12
Yunhua Peng, Xingxiu Wang, Huiqin Feng, Ge Yan
AIM: The purpose of this meta-analysis is to synthesize evidence-based case-control studies to evaluate the association between oral contraceptive (OC) use and the risk of cervical cancer. METHODS: Two reviewers independently selected potentially relevant studies through PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang Data, and the Chongqing VIP databases using the core terms cervical intraepithelial neoplasia/ cervix dysplasia/ cervi* AND oral contraceptive in the article titles, abstracts, and keywords...
May 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28758434/-human-papillomavirus-associated-cervix-uteri-morbidity-in-hungary-epidemiology-and-correlation-with-the-hpv-types-and-the-simultaneous-cytological-diagnosis
#13
Zoltán Szentirmay, Zsuzsa Veleczki, Miklós Kásler
INTRODUCTION: Persistent infection of human papillomavirus is known to cause cervical intraepithelial neoplasia or cancer in the cervix uteri and other HPV-associated cancers in different localization. Based on epidemiological and biological data, principally the high risk HPV is responsible for development of cervical these cancers. However, we have no information about the frequently distribution of different HPV types and what is the correlation between the HPV types and cytological diagnosis in cervical intraepithelial neoplasia (CIN)...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28756395/the-impact-of-bivalent-hpv-vaccine-on-cervical-intraepithelial-neoplasia-by-deprivation-in-scotland-reducing-the-gap
#14
Ross L Cameron, Kimberley Kavanagh, D Cameron Watt, Chris Robertson, Kate Cuschieri, Syed Ahmed, Kevin G Pollock
BACKGROUND: Cervical cancer disproportionately affects women from lower socioeconomic backgrounds. A human papillomavirus (HPV) vaccination programme was introduced in Scotland in 2008 with uptake being lower and inequitable in a catch-up cohort run for the first three years of the programme compared with the routine programme. The socioeconomic differences in vaccine uptake have the potential to further increase the inequality gap in regards to cervical disease. METHODS: Vaccination status was linked to demographic, cytological and colposcopic data, which are routinely collected by the Scottish HPV surveillance system...
July 29, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28742203/expression-levels-and-roles-of-emc-6-beclin1-and-rab5a-in-the-cervical-cancer
#15
M-X Shen, J-B Ding
OBJECTIVE: This study is to investigate the role of EMC-6 in the pathogenesis of cervical cancer, especially concerning its relationship with autophagy. PATIENTS AND METHODS: Totally 100 invasive cervical cancer, 80 cervical intraepithelial neoplasia (CIN), and 80 normal cervical tissue samples were obtained. Expression levels of EMC-6, Beclin1, and Rab5a in the tissues were detected by immunohistochemistry. RESULTS: Our results showed that positive staining of EMC-6 was mainly located in the nucleus...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28737306/the-use-of-cold-coagulation-for-the-treatment-of-cervical-intraepithelial-neoplasia
#16
A Wyse, W A Seah, J O'Neill, P Byrne
In 2015, Cold Coagulation was introduced as a treatment for cervical intraepithelial neoplasia (CIN) at our colposcopy clinic. We reviewed the 6-month follow up data of the first 200 women who underwent Cold Coagulation using cytology and HPV status as tests of cure (TOC). A random sample of 200 patients treated by Large Loop Excision of the Transformation Zone (LLETZ) during the same period was used to compare treatment outcome. Six months following treatment,173 (86.5%) of the women treated by CC and 167 (83...
May 10, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28730227/hpv-genotyping-and-p16%C3%A3-ki-67-dual-staining-in-the-detection-of-high-grade-cervical-lesion-in-patients-with-lsil-on-pap-smear
#17
Lavinia Cristina Moleriu, Ioan Sas, Adrian Claudiu RaŢiu, Mădălin Marius Margan, Cristina Anamaria Secoşan, Răzvan Ştefan Ilina, Florin George Horhat, Loredana Gabriela Stana, Dorin Grigoraş, LaurenŢiu Cornel Pirtea
p16÷Ki-67 dual-stained cytology, either alone or combined with human papillomavirus (HPV) 16÷18 genotyping, could be a useful tool for triage for colposcopy of HPV-positive patients. Based on this background, we aimed at comparing the diagnostic performance of the p16÷Ki-67 dual staining test, and high-risk HPV test for the detection of high-risk cervical intraepithelial neoplasia (CIN2÷3) in patients diagnosed with low-grade squamous intraepithelial lesion (LSIL) on Pap smear. We performed a retrospective study including 184 patients with LSIL cytology on Pap smear, of which 64 were referred for biopsy after colposcopy...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28723743/analysis-of-hpv-distribution-in-patients-with-cervical-precancerous-lesions-in-western-china
#18
Kemin Li, Rutie Yin, Qingli Li, Danqing Wang
Cervical human papillomavirus (HPV) infection is a dangerous disease, whose subtypes exhibit different distribution patterns in particular countries, regions, and races. In this study, the HPV distribution in patients with cervical precancerous lesions in Western China was investigated to assess a probability for prevention of cervical cancer and the clinical application of an HPV vaccine in China. The retrospective study of patients with different HPV subtypes and cervical precancerous lesions, who have undergone loop eelectrosurgical excision procedure, cold knife conization, or a total hysterectomy in our hospital from January 2016 to August 2016, was performed...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28720454/comparative-accuracy-of-pap-smear-and-hpv-screening-in-ubon-ratchathani-in-thailand
#19
Suleeporn Sangrajrang, Piyawat Laowahutanont, Metee Wongsena, Richard Muwonge, Anant Karalak, Weerawut Imsamran, Virginia Senkomago, Rengaswamy Sankaranarayanan
We evaluate the potential for using high-risk human papillomavirus (hr-HPV) testing-based screening for cervical intraepithelial neoplasia (CIN) in routine health services in Thailand; its accuracy in comparison to that of conventional cytology (CC); and the utility of HPV16/18 positive results and liquid-based cytology (LBC) triage for HPV-positive women in the detection of high-grade CIN. Women aged 30-60 years in Ubon Ratchathani province, Thailand were screened with CC and hr-HPV testing and those abnormal on either tests were referred for colposcopy and/or directed biopsies...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720450/detection-of-cervical-precancerous-lesions-with-aptima-hpv-assays-using-surepath-preservative-fluid-specimens
#20
Max Chernesky, Dan Jang, Nick Escott, Jodi Gilchrist, Jenny Li, Laurie Elit, Alice Lytwyn, Marek Smieja, Sam Ratnam, Manuel Arias, Damon Getman, Barbara Weinbaum, Brett Kirkconnell, Janel Dockter
SurePath specimens from women referred to colposcopy were treated with Aptima Transfer Solution (ATS) before testing in Aptima HPV (AHPV) and Aptima HPV 16, 18/45 (AHPV-GT) assays. Untreated SurePath specimens were tested with the cobas HPV test. PreservCyt specimens were assessed for cytology and tested with AHPV. High-grade cervical intraepithelial neoplasia lesions served as the reference standard. Excellent agreement (95.5%; k=0.91) was observed for ATS-treated SurePath specimens between Tigris and Panther systems and between the PreservCyt and ATS-treated SurePath specimens (91...
June 2017: Papillomavirus Research
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