keyword
MENU ▼
Read by QxMD icon Read
search

Cervical intraepithelial neoplasia

keyword
https://www.readbyqxmd.com/read/29783805/-correlation-analysis-of-expression-of-hpv-l1-with-langerhans-cell-and-ki-67-index-in-cervical-intraepithelial-neoplasia
#1
L Zhang, Y M Song, D L Gao, H X Zhang, S L Li
No abstract text is available yet for this article.
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29778314/trends-in-high-grade-cervical-cancer-precursors-in-the-human-papillomavirus-vaccine-era
#2
Fredrick Oakley, Mohamed M Desouki, Manideepthi Pemmaraju, Julia M Gargano, Lauri E Markowitz, Martin Steinau, Elizabeth R Unger, Yuwei Zhu, Oluwole Fadare, Marie R Griffin
INTRODUCTION: The 2006 introduction of human papillomavirus vaccine targeted against genotypes 6, 11, 16, and 18 should result in decreased cervical dysplasia in vaccinated women. However, new cervical cancer guidelines to increase screening intervals complicate interpretation of trends. The hypothesis is that cervical dysplasia would decrease only in young vaccine-eligible women, and not older women. METHODS: The authors identified Davidson County, Tennessee, women aged 18-39 years with cervical intraepithelial neoplasia (CIN) grade 2 or greater and adenocarcinoma in situ, denoted as CIN2+, through pathology reports from laboratories serving this population...
May 16, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29774090/strong-sod2-expression-and-hpv-16-18-positivity-are-independent-events-in-cervical-cancer
#3
Silvia Helena Rabelo-Santos, Lara Termini, Enrique Boccardo, Sophie Derchain, Adhemar Longatto-Filho, Maria Antonieta Andreoli, Maria Cecília Costa, Rafaella Almeida Lima Nunes, Liliana Aparecida Lucci Ângelo-Andrade, Luisa Lina Villa, Luiz Carlos Zeferino
It is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasia grade 3 (CIN3), squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Strong SOD2 expression was significantly higher in ADC (82%) than CIN3 (52%) or SCC (64%)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29770625/risks-of-cervical-intraepithelial-neoplasia-grade-3-or-invasive-cancers-in-ascus-women-with-different-management-a-population-based-cohort-study
#4
Yi Jou Tai, Yun Yuan Chen, Huang Cheng Hsu, Chun Ju Chiang, San Lin You, Chi An Chen, Wen Fang Cheng
OBJECTIVE: To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements. METHODS: Women with their first diagnosis of ASCUS cytology were retrieved from the national cervical cancer screening database and linked to the national health insurance research database to identify the management of these women. The incidences of developing cervical intraepithelial neoplasia grade 3 and invasive cervical cancer (CIN3+) were calculated, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model...
March 20, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29770617/the-use-of-conization-to-identify-and-treat-severe-lesions-among-prediagnosed-cin1-and-2-patients-in-japan
#5
Mikio Mikami, Masae Ikeda, Hidetaka Sato, Haruko Iwase, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi
OBJECTIVE: To evaluate the clinical efficiency of identifying patients with suspicious severe lesions by conization among prediagnosed cervical intraepithelial neoplasia (CIN) 1 and 2 patients in Japan. METHODS: The data in a Japanese nation-wide registry for cervical cancer (2009 and 2011) was collected to analyze the clinical efficacy of pre- and postdiagnosis for 13,215 Japanese women who underwent treatment by conization. Their preoperative and postoperative histologic findings and clinical outcomes were evaluated using standard statistical procedures including clinical and demographic characteristics...
March 8, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29768678/the-ideal-strategy-for-cervical-cancer-screening-in-japan-result-from-the-fukui-cervical-cancer-screening-study
#6
T Kurokawa, T Onuma, A Shinagawa, Y Chino, M Kobayashi, Y Yoshida
OBJECTIVE: The aims of the Fukui Cervical Cancer Screening (FCCS) study are to determine the frequency of women with high-risk HPV (hrHPV), whether HPV16 or HPV18 (HPV16/18), in the Japanese cancer screening population for the first time and to identify the best strategy for cervical cancer screening in Japan. METHODS: This study enrolled 7,584 women ≥25 years of age who were undergoing routine screening. All women underwent liquid-based cytology and cobas HPV tests...
May 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29762428/outcomes-of-conservative-management-of-high-grade-squamous-intraepithelial-lesions-in-young-women
#7
Marette H Lee, Sarah J Finlayson, Ksenia Gukova, Gillian Hanley, Dianne Miller, Leslie Ann Sadownik
OBJECTIVE: The aim of the study was to determine regression rates of cervical intraepithelial neoplasia (CIN) 2 and 3 in women younger than 24 years, followed conservatively for up to 24 months. MATERIALS AND METHODS: This is a retrospective chart review of colposcopy patients in clinic database based on the following: (1) younger than 24 years at first visit; (2) first visit January 1, 2010, to May 31, 2013, and at least 1 follow-up visit after diagnosis; (3) histologic diagnosis of CIN2+; and (4) optimal conservative management (observation for up to 24 months or to 24 years, whichever occurred first)...
May 4, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29752912/association-between-viral-loads-of-different-oncogenic-human-papillomavirus-types-and-the-degree-of-cervical-lesions-in-the-progression-of-cervical-cancer
#8
Wei Wang, Xian-Hui Zhang, Mei Li, Chong-Hua Hao, Zhi-Min Zhao, Hong-Ping Liang
OBJECTIVE: In this study we determined the frequency of the most prevalent human papillomavirus (HPV) types in China and evaluated the association between viral loads of different oncogenic HPV types and the severity of disease. METHODS: We enrolled 15,518 women for this study and 3199 of them (20.61%) were identified as positive by a PCR assay, that can simultaneously quantify and genotype HPV. RESULTS: The viral loads of HPV 16, 31, 35, 52, 58, 39, and 56 were lower for women with normal cytology compared to those with disease progression; viral loads were not appreciable for HPV 33, 18, 45, 59, 68, 53, 66, and 51...
May 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29747434/the-impact-of-human-papilloma-viruses-matrix-metallo-proteinases-and-hiv-protease-inhibitors-on-the-onset-and-progression-of-uterine-cervix-epithelial-tumors-a-review-of-preclinical-and-clinical-studies
#9
REVIEW
Giovanni Barillari, Paolo Monini, Cecilia Sgadari, Barbara Ensoli
Infection of uterine cervix epithelial cells by the Human Papilloma Viruses (HPV) is associated with the development of dysplastic/hyperplastic lesions, termed cervical intraepithelial neoplasia (CIN). CIN lesions may regress, persist or progress to invasive cervical carcinoma (CC), a leading cause of death worldwide. CIN is particularly frequent and aggressive in women infected by both HPV and the Human Immunodeficiency Virus (HIV), as compared to the general female population. In these individuals, however, therapeutic regimens employing HIV protease inhibitors (HIV-PI) have reduced CIN incidence and/or clinical progression, shedding light on the mechanism(s) of its development...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29747338/-role-of-hpv-viral-loads-in-random-biopsy-under-normal-colposcopy
#10
X Q Xu, L Zhang, S Y Hu, Remila Rezhake, X L Zhao, F Chen, X Zhang, Q J Pan, Y L Qiao, F H Zhao
Objective: To explore the role of HPV viral loads in random biopsy under normal colposcopy. Methods: 908 atypical squamous cells of undetermined significance (ASC-US) and HPV positive women, recruited in cluster sampling in 9 provinces including 5 urban areas and 9 rural areas in China from 1999 to 2008 and meeting the inclusion and exclusion criteria were included in this analysis. According to relative light units/cutoff (RLU/CO) value, subjects were stratified as low (286 cases), intermediate (311 cases) and high (311 cases) viral load groups...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29746625/extended-human-papillomavirus-genotype-distribution-and-cervical-cytology-results-in-a-large-cohort-of-chinese-women-with-invasive-cervical-cancers-and-high-grade-squamous-intraepithelial-lesions
#11
Wei Jiang, R Marshall Austin, Lei Li, Kaixuan Yang, Chengquan Zhao
Objectives: To study the human papillomavirus (HPV) genotype distribution of cervical cancer (CxCa) and cervical intraepithelial neoplasia grade 2/3 (CIN2/3) in China and to evaluate cotesting of HPV and cytology in CxCa screening. Methods: Patients with histopathologic CxCa and CIN 2/3 diagnoses reported between January 2012 and June 2016 and extended HPV genotype testing in the prior 6 months were documented in the institute. Available prior Papanicolaou (Pap) test results were also documented...
April 16, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29746299/suppressive-antiretroviral-therapy-associates-with-effective-treatment-of-high-grade-cervical-intraepithelial-neoplasia
#12
Christina Carlander, Philippe Wagner, Astrid van Beirs, Aylin Yilmaz, Kristina Elfgren, Joakim Dillner, Anders Sönnerborg, Pär Sparén
OBJECTIVES: To assess if women living with HIV (WLWH) have poorer outcome after treatment of cervical intraepithelial neoplasia (CIN2+) than HIV-negative women and to identify predictors of CIN2+ treatment failure and recurrence in WLWH. DESIGN: Population-based cohort study with follow-up between 1983 and 2015. METHODS: The Swedish National HIV Registry, the Swedish Population Registry and the Swedish National Cervical Screening Registry were linked to identify all women in Stockholm and Gothenburg counties (Sweden) living with HIV and diagnosed with CIN2+ (n = 179) sometime between 1983 and 2014...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29744680/association-of-antibody-to-e2-protein-of-human-papillomavirus-and-p16-ink4a-with-progression-of-hpv-infected-cervical-lesions
#13
Jureeporn Chuerduangphui, Chamsai Pientong, Piyawut Swangphon, Sanguanchoke Luanratanakorn, Ussanee Sangkomkamhang, Thumwadee Tungsiriwattana, Pilaiwan Kleebkaow, Ati Burassakarn, Tipaya Ekalaksananan
Human papillomavirus (HPV) E2 and L1 proteins are expressed in cervical cells during the lytic stage of infection. Overexpression of p16INK4A is a biomarker of HPV-associated cervical neoplasia. This study investigated antibodies to HPV16 E2, HPV16 L1, and p16INK4A in sera from women with no squamous intraepithelial lesion (No-SIL) of the cervix, low-grade SIL, high-grade SIL, and cervical squamous cell carcinoma (SCC). HPV DNA was detected by polymerase chain reaction. Anti-E2, -L1, and -p16INK4A antibodies in sera were determined by western blot...
May 9, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29740819/prophylactic-vaccination-against-human-papillomaviruses-to-prevent-cervical-cancer-and-its-precursors
#14
REVIEW
Marc Arbyn, Lan Xu, Cindy Simoens, Pierre Pl Martin-Hirsch
BACKGROUND: Persistent infection with high-risk human papillomaviruses (hrHPV) types is causally linked with the development of cervical precancer and cancer. HPV types 16 and 18 cause approximately 70% of cervical cancers worldwide. OBJECTIVES: To evaluate the harms and protection of prophylactic human papillomaviruses (HPV) vaccines against cervical precancer and HPV16/18 infection in adolescent girls and women. SEARCH METHODS: We searched MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase (June 2017) for reports on effects from trials...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29734247/clinical-and-economic-value-of-p16ink4a-for-the-differential-diagnosis-of-morphologic-cervical-intraepithelial-neoplasia-2
#15
Vanina S Fishkel, Fernando C Monge, Felicitas M von Petery, Karen E Tapper, Teresa M Peña, Florencia Torres, Fernando A Poletta, Jorge F Elgart, Alejandra Avagnina, Valeria Denninghoff
The detection of high-grade intraepithelial lesions requires highly sensitive and specific methods that allow more accurate diagnoses. This contributes to a proper management of preneoplastic lesions, thus avoiding overtreatment. The purpose of this study was to analyze the value of immunostaining for p16 in the morphologic assessment of cervical intraepithelial neoplasia 2 lesions, to help differentiate between low-grade (p16-negative) and high-grade (p16-positive) squamous intraepithelial lesions. The direct medical cost of the treatment of cervical intraepithelial neoplasia 2 morphologic lesions was estimated...
May 4, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29728572/identification-of-mirnas-in-cervical-mucus-as-a-novel-diagnostic-marker-for-cervical-neoplasia
#16
Satoshi Kawai, Takuma Fujii, Iwao Kukimoto, Hiroya Yamada, Naoki Yamamoto, Makoto Kuroda, Sayaka Otani, Ryoko Ichikawa, Eiji Nishio, Yutaka Torii, Aya Iwata
microRNAs (miRNAs) play important roles in regulation of gene expression during cervical carcinogenesis. We investigated expression profiles of miRNAs in cervical cancer and its precursor lesions by utilizing cervical mucus. Cervical mucus was collected from 230 patients with a normal cervix, cervical intraepithelial neoplasia (CIN), squamous cell carcinoma (SCC), or adenocarcinoma (AD). The levels of miRNA in the mucus were quantified by miRNA array and real-time reverse-transcriptase polymerase chain reaction (RT-PCR)...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29721172/loss-of-nuclear-notch1-but-not-its-negative-regulator-numb-is-an-independent-predictor-of-cervical-malignancy
#17
Elenaé Vázquez-Ulloa, Ana Clara Ramos-Cruz, Diddier Prada, Alejandro Avilés-Salas, Alma Delia Chávez-Blanco, Luis A Herrera, Marcela Lizano, Adriana Contreras-Paredes
The participation of NOTCH signaling in invasive cervical cancer (ICC) remains controversial since both tumor suppressive and oncogenic properties have been described. Additionally, the role of NUMB, a negative regulator of NOTCH, remains unclear in ICC. We aimed to investigate the role of NOTCH1 and NUMB expression and their localization in cervical intraepithelial neoplasia (CIN) and ICC samples. A total of 144 biopsies were obtained from the Instituto Nacional de Cancerología, México from 2004 to 2017, and were subjected to immunohistochemistry for NOTCH1 and NUMB...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29720427/up-regulation-of-inflammation-related-lncrna-il7r-predicts-poor-clinical-outcome-of-patients-with-cervical-cancer
#18
Yangyang Fan, Yan Nan, Juanjuan Huang, Hui Zhong, Weidong Zhou
The long-term chronic inflammation of cervical intraepithelial neoplasia (CIN) induces the initiation and progression of cervical cancer. Long non-coding RNAs (LncRNAs) are being identified to be involved into inflammation and carcinogenesis and could function as cancer biomarkers in clinical. However, the significance of inflammation-related LncRNA (e.g. LncRNA-IL7R) in cervical cancer is limited. We here investigated the clinical role of inflammation-related LncRNA-IL7R (Lnc-IL7R) in healthy cervical tissue (n=15), CIN 1/2/3 (n=35), cervical cancer (n=70), and clarified its function via knockdown in vitro and in vivo The results showed that the expression of Lnc-IL7R was increased from normal tissues to neoplastic lesions and cervical cancer...
May 2, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29719625/host-chemokine-signature-as-a-biomarker-for-the-detection-of-pre-cancerous-cervical-lesions
#19
Ramya Bhatia, Kim Kavanagh, June Stewart, Sharon Moncur, Itziar Serrano, Duanduan Cong, Heather A Cubie, Juergen G Haas, Camille Busby-Earle, Alistair R W Williams, Sarah E M Howie, Kate Cuschieri
Background: The ability to distinguish which hrHPV infections predispose to significant disease is ever more pressing as a result of the increasing move to hrHPV testing for primary cervical screening. A risk-stratifier or "triage" of infection should ideally be objective and suitable for automation given the scale of screening. Results: CCL2, CCL3, CCL4, CXCL1, CXCL8 and CXCL12 emerged as the strongest, candidate biomarkers to detect underlying disease [cervical intraepithelial neoplasia grade 2 or worse (CIN2+)]...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29712686/cdk9-inhibitor-fit-039-suppresses-viral-oncogenes-e6-and-e7-and-has-a-therapeutic-effect-on-hpv-induced-neoplasia
#20
Masahiko Ajiro, Hiroyuki Sakai, Hiroshi Onogi, Makoto Yamamoto, Eriko Sumi, Teruo Sawada, Takashi Nomura, Kenji Kabashima, Takamitsu Hosoya, Masatoshi Hagiwara
PURPOSE: Cervical cancer is one of the leading causes of cancer deaths among women worldwide. The purpose of this study is to assess the therapeutic effect of the newly developed cyclin-dependent kinase 9 (CDK9) inhibitor FIT-039 on cervical neoplasia induced by human papillomavirus (HPV) infection. EXPERIMENTAL DESIGN: We examined FIT-039 for its effect on HPV gene expression in HPV+ cervical cancer cells. Primary keratinocytes monolayer and organotypic raft culture models were used to evaluate HPV viral replication and cervical intraepithelial neoplasia (CIN) phenotypes...
April 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
keyword
keyword
116378
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"