keyword
MENU ▼
Read by QxMD icon Read
search

Cervical intraepithelial neoplasia

keyword
https://www.readbyqxmd.com/read/29165793/risk-of-preterm-birth-in-women-with-cervical-intraepithelial-neoplasia-grade-one-a-population-based-cohort-study
#1
Annu Heinonen, Mika Gissler, Jorma Paavonen, Anna-Maija Tapper, Maija Jakobsson
INTRODUCTION: In this population based register study our objective was to explore the association of cervical intraepithelial neoplasia, grade 1 (CIN1) and loop electrosurcigal excision procedure (LEEP) with preterm birth (PTB). MATERIAL AND METHODS: Our population consisted of 4 759 women diagnosed for CIN1 during 1997-2009 and their 3 021 subsequent deliveries analyzed by LEEP and parity. Hospital Discharge Register was used to identify women diagnosed for CIN1 and this data were linked with the Medical Birth Register data...
November 22, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29159802/adenovirus-vector-based-prime-boost-vaccination-via-heterologous-routes-induces-cervicovaginal-cd8-t-cell-responses-against-hpv16-oncoproteins
#2
Nicolas Çuburu, Selina Khan, Cynthia D Thompson, Rina Kim, Jort Vellinga, Roland Zahn, Douglas R Lowy, Gert Scheper, John T Schiller
Recent advances in immunotherapy against cancer underscore the importance of T lymphocytes and tumor microenvironment, but few vaccines targeting cancer have been approved likely due in part to the dearth of common tumor antigens, insufficient immunogenicity and the evolution of immune evasion mechanisms during the progression to malignancy. Human papillomaviruses (HPV) are the primary etiologic agents of cervical cancer and progression from persistent HPV-infection to cervical intraepithelial lesions and eventually cancer requires persistent expression of the oncoproteins E6 and E7...
November 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29157955/development-of-a-goat-model-for-evaluation-of-withaferin-a-cervical-implants-for-the-treatment-of-cervical-intraepithelial-neoplasia
#3
Leslie C Sherwood, Farrukh Aqil, Manicka V Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay Srivastava, Inder P Singh, Scott Cambron, Martin O'Toole, Wendy Spencer, Lynn P Parker, Ramesh C Gupta
Cervical cancer is caused by human papillomavirus (HPV). The disease develops over many years through a series of precancerous lesions. Cervical cancer can be prevented by HPV-vaccination, screening and treatment of precancer before development of cervical cancer. The treatment of high-grade cervical dysplasia (CIN(2+)) has traditionally been by cervical conization. Surgical procedures are associated with increased risk of undesirable side effects including bleeding, infection, scarring (stenosis), infertility and complications in later pregnancies...
November 17, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29152130/the-association-between-polymorphisms-in-microrna-genes-and-cervical-cancer-in-a-chinese-han-population
#4
Li Chuanyin, Wang Xiaona, Yan Zhiling, Zhang Yu, Liu Shuyuan, Yang Jie, Hong Chao, Shi Li, Yang Hongying, Yao Yufeng
Several studies have confirmed the crucial roles of microRNAs (miRNAs) in cancer occurrence. In addition, single nucleotide polymorphisms (SNPs) in miRNA genes have been associated with various cancers. The aim of the present study was to investigate the association of SNPs in miRNA genes with cervical intraepithelial neoplasia (CIN) and cervical cancer in a Chinese Han population. We searched SNPs in nineteen miRNAs by sequencing healthy individuals (n=50). Then, a total of 400 patients with CIN, 609 patients with cervical cancer and 583 healthy individuals were recruited to genotype the SNPs using a Taqman assay...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151975/clinical-significance-of-cd163-and-cd68-tumor-associated-macrophages-in-high-risk-hpv-related-cervical-cancer
#5
Xiao-Jing Chen, Ling-Fei Han, Xiang-Guang Wu, Wen-Fei Wei, Lan-Fang Wu, Hong-Yan Yi, Rui-Ming Yan, Xiang-Yang Bai, Mei Zhong, Yan-Hong Yu, Li Liang, Wei Wang
Objective. To explore the influence of M2-polarized tumor-associated macrophages (TAMs) on high-risk human papillomavirus (hr-HPV)-related cervical carcinogenesis and metastasis. Methods. CD68+ and CD163+ macrophages were examined immunohistochemically in a series of 130 samples, including 26 cases of normal cervical tissues, 59 cases of cervical intraepithelial neoplasia (CIN), and 45 cases of squamous cell carcinoma (SCC), and the results were statistically analyzed. The macrophage count was corrected for the epithelial and stromal compartments respectively...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151910/role-and-importance-of-the-expression-of-transcription-factor-foxc2-in-cervical-cancer
#6
Jing Wang, Xiujuan Yue
The aim of the present study was to investigate the relationship between the expression of transcription factor forkhead box C2 (FOXC2) and the clinical features of cervical cancer. A total of 66 patients with cervical cancer, 42 patients with cervical intraepithelial neoplasia (CIN) and 25 patients with cervical inflammation were enrolled. The positive expression rates and expression levels of mRNA of FOXC2, E-cadherin, N-cadherin, vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 (SDF-1), Notch protein and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) in cervical tissues were detected using immunohistochemistry and RT-PCR...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29144557/penile-warty-mucoepidermoid-carcinoma-with-features-of-stratified-mucin-producing-intraepithelial-lesion-and-invasive-stratified-mucin-producing-carcinoma
#7
Kenji Yorita, Naoto Kuroda, Takushi Naroda, Masato Tamura, Chisato Ohe, Mukul Divatia, Mahul B Amin, Antonio L Cubilla, Dimitry V Kazakov, Ondrej Hes, Michael Michal, Michal Michal
AIMS: Stratified mucin-producing intraepithelial lesion (SMILE) and invasive stratified mucin-producing carcinoma (ISMC) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE/ISMC features. METHODS AND RESULTS: A 62-year-old Japanese man had a glans penis lesion of one and a half years duration, suggesting malignancy. Partial penectomy and left inguinal lymphadenectomy were performed...
November 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29143102/diagnostic-performance-of-hpv-e6-e7-mrna-assay-for-detection-of-cervical-high-grade-intraepithelial-neoplasia-and-cancer-among-women-with-ascus-papanicolaou-smears
#8
Chenchen Ren, Yuanhang Zhu, Li Yang, Xiaoan Zhang, Ling Liu, Chunying Ren
PURPOSE: The aim of this study was to investigate the clinical performance of high risk (HR) HPV E6/E7 mRNA assay in detecting cervical high-grade intraepithelial neoplasia and cancer among women with atypical squamous cells of undetermined significance (ASCUS) Papanicolaou (Pap) smears. METHODS: A total of 160 patients with ASCUS who underwent HR-HPV DNA assay, HR-HPV E6/E7 mRNA assay and colposcopy biopsy at Third Affiliated Hospital of Zhengzhou University, China, from December 2015 to March 2017, were enrolled...
November 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29140880/high-risk-human-papillomavirus-determination-in-formalin-fixed-paraffin-embedded-cervical-tissue-using-the-roche-cobas-4800-system-a-comparative-study-with-liquid-based-cytology
#9
Juan C Tardío, Olivia Cambero, Carolina Sánchez-Estévez, Ana B Sánchez-García, Fernando Angulo, Amalia Moreno
Roche cobas 4800 human papillomavirus (HPV) test is an automated real-time polymerase chain reaction-based system that allows the simultaneous detection of 14 human papillomavirus high-risk (HR-HPV) genotypes. This test is Food and Drug Administration approved since 2011 for HPV determination in liquid-based cytologic samples, but a clinically validated technique for formalin-fixed, paraffin-embedded (FFPE) tissue specimens is presently not commercially available. In our laboratory, we have developed an HPV detection procedure in FFPE tissue by cobas 4800 HPV test...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29136403/high-grade-cervical-intraepithelial-neoplasia-in-human-papillomavirus-self-sampling-of-screening-non-attenders
#10
J U H Lam, K M Elfström, D M Ejegod, H Pedersen, C Rygaard, M Rebolj, E Lynge, K E Juul, S K Kjær, J Dillner, J Bonde
BACKGROUND: Self-sampling for human papillomavirus (HPV) offered to women who do not participate in cervical cancer screening is an increasingly popular method to increase screening coverage. The rationale behind self-sampling is that unscreened women harbour a high proportion of undetected precancer lesions. Here, we compare the cervical intraepithelial neoplasia grade 2 or worse (⩾CIN2) detection rate between non-attenders who participated in self-sampling and women attending routine screening...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29131134/mannose-binding-lectin-is-not-acting-as-a-biomarker-for-the-progression-of-pre-invasive-lesions-of-invasive-cervical-cancer
#11
Carlos Afonso Maestri, Renato Nisihara, Guilherme P Ramos, Hellen Weinschutz Mendes, Iara Messias-Reason, Newton Sérgio de Carvalho
OBJECTIVE: To evaluate serum concentrations of mannose binding lectin (MBL) in women presenting with different human papilloma virus (HPV)-associated cervical lesions. SUBJECTS AND METHODS: A total of 364 women, who underwent screening for cervical cancer or treatment at Erasto Gaertner Cancer Hospital (HEG), Curitiba, Southern region, Brazil, were enrolled in the study. Based on latest cervical colposcopy-guided biopsy results, the women were divided into four groups: cervical intraepithelial neoplasia (CIN) CIN-I (n=54); CIN-II (n=72); CIN-III (n=145) and invasive cancer (n=93)...
November 7, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29126708/incomplete-excision-of-cervical-precancer-as-a-predictor-of-treatment-failure-a-systematic-review-and-meta-analysis
#12
Marc Arbyn, Charles W E Redman, Freija Verdoodt, Maria Kyrgiou, Menelaos Tzafetas, Sadaf Ghaem-Maghami, Karl-Ulrich Petry, Simon Leeson, Christine Bergeron, Pekka Nieminen, Jean Gondry, Olaf Reich, Esther L Moss
BACKGROUND: Incomplete excision of cervical precancer is associated with therapeutic failure and is therefore considered as a quality indicator of clinical practice. Conversely, the risk of preterm birth is reported to correlate with size of cervical excision and therefore balancing the risk of adequate treatment with iatrogenic harm is challenging. We reviewed the literature with an aim to reveal whether incomplete excision, reflected by presence of precancerous tissue at the section margins, or post-treatment HPV testing are accurate predictors of treatment failure...
November 7, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29120834/cervical-cancer-screening-in-the-national-breast-and-cervical-cancer-early-detection-program-nbccedp-in-four-us-affiliated-pacific-islands-between-2007-and-2015
#13
Virginia Senkomago, Janet Royalty, Jacqueline W Miller, Lee E Buenconsejo-Lum, Vicki B Benard, Mona Saraiya
BACKGROUND: Cervical cancer incidence in the US-Affiliated Pacific Islands (USAPIs) is double that of the US mainland. American Samoa, Commonwealth of Northern Mariana Islands (CNMI), Guam and the Republic of Palau receive funding from the Centers for Disease Control (CDC) National Breast and Cervical Cancer Early Detection Program (NBCCEDP) to implement cervical cancer screening to low-income, uninsured or under insured women. The USAPI grantees report data on screening and follow-up activities to the CDC...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29118475/histological-follow-up-in-patients-with-atypical-glandular-cells-on-pap-smears
#14
Gokhan Boyraz, Derman Basaran, Mehmet Coskun Salman, Akbar Ibrahimov, Sevgen Onder, Orkun Akman, Nejat Ozgul, Kunter Yuce
Context: Atypical glandular cells (AGCs) result in the Papanicolaou (Pap) smear may be associated with significant genital and nongenital neoplastic processes. Aims: To evaluate the underlying histopathology in women who had AGCs on Pap smears. Settings and Design: Retrospective cross-sectional study. Patients and Methods: Clinicopathological data of patients who had AGC on Pap smears and underwent histological workup between January 2004 and December 2014 were retrieved from the computerized database of a tertiary care center...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29115500/roles-and-mechanisms-of-trpc3-and-the-plc%C3%AE-pkc-cpi-17-signaling-pathway-in-regulating-parturition
#15
Jing Chen, Dongming Zheng, Hong Cui, Sishi Liu, Lijuan Zhang, Caixia Liu
The aim of the current study was to investigate the role of phospholipase C (PLC)γ/protein kinase C (PKC)/C‑kinase‑activated protein phosphatase‑1 (CPI‑17) signaling pathways in uterine smooth muscle during parturition. Samples of uterine tissue were collected from pregnant patients who underwent a caesarean section for preterm delivery, full‑term delivery with labor onset, full‑term delivery without labor onset, and from a non‑pregnant control group undergoing surgery for cervical intraepithelial neoplasia III...
November 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113275/e6-e7-proteins-are-potential-markers-for-the-screening-and-diagnosis-of-cervical-pre-cancerous-lesions-and-cervical-cancer-in-a-chinese-population
#16
Wen-Jing Shi, Hao Liu, Dan Wu, Zhen-Hua Tang, Yu-Chen Shen, Lin Guo
The present prospective study aimed to evaluate the effects of E6/E7 protein detection by western blotting on cervical cancer (CC) early screening compared with detection by Hybrid Capture 2 (HC2) test and ThinPrep cytological test (TCT) in a Chinese population. A total of 450 cases of cervical intraepithelial neoplasia (CIN) suspected samples (positive in ≥1 indicator of TCT and HC2 test) were recruited from women who were treated at the International Peace Maternity and Child Health Hospital (Shanghai, China) from March 2014 to February 2015...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29113168/negative-correlation-between-x-linked-inhibitors-of-apoptosis-and-second-mitochondria-derived-activator-of-caspase-expression-levels-in-cervical-carcinoma-and-cervical-intraepithelial-neoplasia
#17
Xue-Jing Jin, Ping-Sheng Cai, Shu-Pin Zhu, Li-Jie Wang, Hua Zhu
X-linked inhibitors of apoptosis (XIAP) and second mitochondria-derived activator of caspase (Smac) have been widely reported to serve roles in the development of cervical carcinoma. The present study analyzed the associations between the expression levels of XIAP and Smac in normal cervical epithelium, cervical intraepithelial neoplasia (CIN) and cervical carcinoma. Immunohistochemistry staining of formalin-fixed, paraffin-embedded tissue sections was performed in order to analyze the expression levels of XIAP and Smac in 15 cases of normal cervical tissues, 69 cases of CIN and 76 cases of cervical carcinoma...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112672/diagnosis-of-cervical-precancers-by-endocervical-curettage-at-colposcopy-of-women-with-abnormal-cervical-cytology
#18
Angela Hui-Chia Liu, Joan Walker, Julia C Gage, Michael A Gold, Rosemary Zuna, S Terence Dunn, Mark Schiffman, Nicolas Wentzensen
OBJECTIVE: To evaluate the performance of routine endocervical curettage (ECC) for diagnosing high-grade cervical intraepithelial neoplasia (CIN) 2 or worse and additional precancers not otherwise detected by ectocervical biopsies. METHODS: In a secondary analysis of the Biopsy Study, a cross-sectional study conducted between 2009 and 2012 at the University of Oklahoma Health and Sciences Center that found an incremental increase in detection of cervical precancers by multiple biopsies at colposcopy, ECC was performed in most women aged 30 years or older...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29112652/effect-of-cervical-cancer-screening-programs-on-preterm-birth-a-decision-and-cost-effectiveness-analysis
#19
Esmé I Kamphuis, Steffie K Naber, Noor A Danhof, J Dik F Habbema, Christianne J M de Groot, Ben W J Mol
OBJECTIVE: To assess the effect of age at initiation and interval of cervical cancer screening in women of reproductive age on the risk of future preterm birth and subsequent adverse neonatal outcome relative to maternal life-years gained and cost of both screening and preterm birth. METHODS: In this decision and cost-effectiveness analysis, we compared eight cytology-based screening programs varying in age of onset (21, 24, 25, 27, or 30 years) and screening interval (3 or 5 years) in a fictive cohort of 100,000 women...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29112645/topical-5-fluorouracil-for-women-with-high-grade-vaginal-intraepithelial-neoplasia
#20
Stephen Fiascone, Allison F Vitonis, Sarah Feldman
OBJECTIVE: To examine success rates of 5-fluorouracil, excision, and laser ablation as the initial and secondary management strategies for women with high-grade vaginal intraepithelial neoplasia. METHODS: We conducted a retrospective case series of women referred to a single center for management of biopsy-proven, high-grade vaginal intraepithelial neoplasia between April 1994 and May 2016. Data including demographic characteristics, human papillomavirus risk factors, antecedent Pap cytology, concurrent or prior cervical and vulvar dysplasia, and treatment outcome including follow-up Pap cytology were recorded...
November 3, 2017: Obstetrics and Gynecology
keyword
keyword
116378
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"