Maria Garcia-Bonilla, Alexander T Yahanda, Albert M Isaacs, Brandon Baksh, S Hassan A Akbari, Haley Botteron, Diego M Morales, Rowland H Han, James P McAllister Ii, Amit M Mathur, Jennifer M Strahle, Christopher D Smyser, David D Limbrick
BACKGROUND: Interpretation of cerebrospinal fluid (CSF) studies can be challenging in preterm infants. We hypothesized that intraventricular hemorrhage (IVH), post-hemorrhagic hydrocephalus (PHH), and infection (meningitis) promote pro-inflammatory CSF conditions reflected in CSF parameters. METHODS: Biochemical and cytological profiles of lumbar CSF and peripheral blood samples were analyzed for 81 control, 29 IVH grade 1/2 (IVH1/2 ), 13 IVH grade 3/4 (IVH3/4 ), 15 PHH, 20 culture-confirmed bacterial meningitis (BM), and 27 viral meningitis (VM) infants at 36...
February 21, 2024: Fluids and Barriers of the CNS