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timing of intracranial hemorrhage neonate

Qianwei Chen, Zhou Feng, Qiang Tan, Jing Guo, Jun Tang, Liang Tan, Hua Feng, Zhi Chen
Post-hemorrhagic hydrocephalus (PHH), also referred to as progressive ventricular dilatation, is caused by disturbances in cerebrospinal fluid (CSF) flow or absorption following hemorrhage in the brain. As one of the most serious complications of neonatal/adult intraventricular hemorrhage (IVH), subarachnoid hemorrhage (SAH), and traumatic brain injury (TBI), PHH is associated with increased morbidity and disability of these events. Common sequelae of PHH include neurocognitive impairment, motor dysfunction, and growth impairment...
April 15, 2017: Journal of the Neurological Sciences
Kristen Rundell, Bethany Panchal
In the United States, preterm delivery is the leading cause of neonatal morbidity and is the most common reason for hospitalization during pregnancy. The rate of preterm delivery (before 37 weeks' gestation) has been declining since 2007. Clinical diagnosis of preterm labor is made if there are regular contractions and concomitant cervical change. Less than 10% of women with a clinical diagnosis of preterm labor will deliver within seven days of initial presentation. Women with a history of spontaneous preterm delivery are 1...
March 15, 2017: American Family Physician
Sarah Lee, David M Mirsky, Lauren A Beslow, Catherine Amlie-Lefond, Amy R Danehy, Laura Lehman, Nicholas V Stence, Arastoo Vossough, Max Wintermark, Michael J Rivkin
PURPOSE: To provide consensus-based, suggested imaging protocols to facilitate the accurate and timely diagnosis of a neonate with symptoms concerning for stroke. METHODS: The Writing Group, an international collaboration of pediatric neurologists and neuroradiologists with expertise in perinatal and childhood stroke, participated in a series of pediatric stroke neuroimaging symposia. These discussions, in conjunction with extensive literature review, led to a consensus for imaging protocols to guide practitioners in the diagnosis of neonatal stroke subtypes as defined by the National Institute of Neurological Disorders and Stroke Common Data Elements...
January 26, 2017: Pediatric Neurology
Sabahattin Ertugrul, Fesih Aktar, Ilyas Yolbas, Ahmet Yilmaz, Bilal Elbey, Ahmet Yildirim, Kamil Yilmaz, Recep Tekin
BACKGROUND: Healthcare-associated bloodstream infections (HCA-BSI) are a major cause of morbidity and mortality in neonatal intensive care units (NICUs). OBJECTIVES: We aimed to determine the causative organisms and risk factors of HCA-BSIs in NICUs. METHODS: This study was performed between January 2011 and December 2014 in the neonatal intensive care unit of Dicle university, Turkey. The study consisted of 126 patients (infected group) with positive blood culture and 126 randomly selected patients (uninfected control group) with negative blood culture after four days of hospitalization...
October 2016: Iranian Journal of Pediatrics
Hirofumi Inoue, Shin-Ichi Terachi, Takeshi Uchiumi, Tetsuji Sato, Michiyo Urata, Masataka Ishimura, Yui Koga, Taeko Hotta, Toshiro Hara, Dongchon Kang, Shouichi Ohga
BACKGROUND: Severe protein C (PC) deficiency is a rare heritable thrombophilia leading to thromboembolic events during the neonatal period. It remains unclear how individuals with complete PC gene (PROC) defects develop or escape neonatal stroke or purpura fulminans (PF). PROCEDURE: We studied the onset of disease and the genotype of 22 PC-deficient patients with double mutations in PROC based on our cohort (n = 12) and the previous reports (n = 10) in Japan. RESULTS: Twenty-two patients in 20 unrelated families had 4 homozygous and 18 compound heterozygous mutations...
January 23, 2017: Pediatric Blood & Cancer
Wu Qiu, Yimin Chen, Jessica Kishimoto, Sandrine de Ribaupierre, Bernard Chiu, Aaron Fenster, Jing Yuan
Preterm neonates with a very low birth weight of less than 1,500 g are at increased risk for developing intraventricular hemorrhage (IVH). Progressive ventricle dilatation of IVH patients may cause increased intracranial pressure, leading to neurological damage, such as neurodevelopmental delay and cerebral palsy. The technique of 3D ultrasound (US) imaging has been used to quantitatively monitor the ventricular volume in IVH neonates, which may elucidate the ambiguity surrounding the timing of interventions in these patients as 2D clinical US imaging relies on linear measurement and visual estimation of ventricular dilation from a series of 2D slices...
July 9, 2016: Medical Image Analysis
Meena Khandelwal, Vanitha B Revanasiddappa, Sindy C Moreno, Gunda Simpkins, Stuart Weiner, Thomas Westover
INTRODUCTION: Current ACOG technical bulletin #144, 2014 states "Women with monoamniotic twin gestations should undergo cesarean delivery to avoid an umbilical cord complication of the nonpresenting twin at the time of the initial twin's delivery." To assess feasibility of vaginal delivery, we compared neonatal outcomes after attempted VD versus planned cesarean delivery (CD). METHODS: This retrospective cohort study from 2 tertiary-care centers, reviewed all viable MoMo twin pregnancies beyond 24 weeks gestation, delivered over last 15 years...
May 2016: Obstetrics and Gynecology
Qi-Jun Wu, Li-Li Li, Jing Li, Chen Zhou, Yan-Hong Huang
To investigate the rate and time trends of neonatal mortality from 1997 to 2014 in Shenyang, which were previously rarely reported upon by developing countries, data on 4719 neonatal deaths (0-28 days) and 970,583 live births from the Shenyang Women and Children Health Care Centre were analyzed. Neonatal mortality rates (per 1000 live births), percent change, and annual percent change (APC) were calculated. During the observation period, neonatal mortality in Shenyang significantly decreased by 7.04%, 8.33%, and 5...
March 29, 2016: Oncotarget
Xueyan Wang, Chao Zhang, Meiying Liang, Xiaohong Zhang, Jianliu Wang, Xia Zhang
OBJECTIVE: To explore the pregnancy outcomes of women with pancytopenia and the risk factors for the adverse perinatal outcomes. METHODS: A total of 106 pregnant women with pancytopenia were admitted to Peking University People's Hospital from Jan. 2005 to Sep. 2014. The clinical data and the pregnancy outcomes were reviewed retrospectively to investigate the risk factors for the adverse perinatal outcomes. RESULTS: (1 ) Eighty-four patients were found pancytopenia before pregnancy while 22 were found for the first time during pregnancy...
December 2015: Zhonghua Fu Chan Ke za Zhi
Celso Moura Rebello, Luciene Ferreira do Amaral Nacif, Alice D Agostini Deutsch, Ângela Tavares Paes
OBJECTIVE: To correlate the timing of treatment using exogenous surfactant with the main variables related to respiratory distress syndrome or prematurity. METHODS: A historic cohort study between January 1, 2004 and June 30, 2007, including very low birth weight newborns (birth weight <1,500 g) admitted to the hospital and who required surfactant therapy. Newborns were divided into three study groups: early (treatment during the first two hours); intermediate (treatment between two and six hours) and late (treatment after six hours)...
September 2010: Einstein
Edyta Zielonka-Lamparska, Andrzej Paweł Wieczorek
Due to the possibility to examine at the patient bedside or incubator, ultrasound imaging of the central nervous system, particularly through the anterior fontanelle, is the most common diagnostic examination performed in neonates and infants with neurological problems. Despite its common application, this method has certain limitations. These limitations are associated with cross-sections of the cerebral structures that can be obtained when examining through the anterior fontanelle. The aim of the paper was to assess the usefulness of three dimensional sonography of the central nervous system in neonates and infants in the assessment of intracranial bleeding and its consequences when examined through the anterior fontanelle...
December 2013: Journal of Ultrasonography
Jian Wang, Xuehua Liu, Tong Zhu, Chaoying Yan
OBJECTIVE: To find more effective diagnosis and treatment of NRDS through comparatively analyzing the different gestational neonates with respiratory distress syndrome in risk factors, clinical characteristics, treatment and prognosis. METHODS: The clinical data of 232 neonates were retrospectively analyzed who had been admitted into the neonatal intensive care unit and diagnosed with NRDS from January 2008 to December 2010. These cases were divided into three groups according to gestational age, which included full-term group, late preterm and early preterm group...
2015: International Journal of Clinical and Experimental Medicine
Yimin Chen, Wu Qiu, Jessica Kishimoto, Yuan Gao, Rosa H M Chan, Sandrine de Ribaupierre, Aaron Fenster, Bernard Chiu
PURPOSE: Intraventricular hemorrhage (IVH) is a major cause of brain injury in preterm neonates. Three dimensional ultrasound (US) imaging systems have been developed to visualize 3D anatomical structure of preterm neonatal intracranial ventricular system with IVH and ventricular dilation. To allow quantitative analysis, the ventricle system is required to be segmented accurately and efficiently from 3D US images. Although semiautomatic segmentation algorithms have been developed, local segmentation accuracy and variability associated with these algorithms should be evaluated statistically before they can be applied in clinical settings...
November 2015: Medical Physics
Hui-Ling Fu, Li Liu, Juan Zhang, Quan-Li Wang
OBJECTIVE: To investigate the clinical features, prevention and treatment of respiratory distress syndrome (RDS) in neonates of different gestational ages (GA) in the tertiary hospitals in Northwest China. METHODS: A total of 440 neonates diagnosed with RDS between January and December, 2011 in 12 tertiary hospitals in Northwest China were enrolled and classified into three groups: early preterm (GA<34 weeks; n=247), late preterm (GA 34-36(+6) weeks; n=131) and full-term (GA≥37 weeks; n=62)...
October 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Abdullah Ceylan, Suat Gezer, Nihat Demir, Oğuz Tuncer, Erdal Peker, Ercan Kırımi
AIM: Mechanical ventilation is an invasive method and causes to important problems in the respiratory tract and lung parenchyma. The objective of our study was to investigate if administration of early surfactant and nasal continuous positive airway pressure (nCPAP) was superior to delayed surfactant administration and mechanical ventilation. MATERIAL AND METHODS: The study was conducted in the Van 100th Year University, Medical Faculty Hospital, Neonatal Intensive Care Unit...
September 2014: Türk Pediatri Arşivi
Wu Qiu, Jing Yuan, Martin Rajchl, Jessica Kishimoto, Yimin Chen, Sandrine de Ribaupierre, Bernard Chiu, Aaron Fenster
Intraventricular hemorrhage (IVH) or bleed within the cerebral ventricles is a common condition among very low birth weight pre-term neonates. The prognosis for these patients is worsened should they develop progressive ventricular dilatation, i.e., post-hemorrhagic ventricle dilatation (PHVD), which occurs in 10-30% of IVH patients. Accurate measurement of ventricular volume would be valuable information and could be used to predict PHVD and determine whether that specific patient with ventricular dilatation requires treatment...
September 2015: NeuroImage
Ijeoma Esiaba, Danilyn M Angeles, Megan S Holden, John B C Tan, Yayesh Asmerom, Gerald Gollin, Danilo S Boskovic
Germinal matrix intraventricular hemorrhage (IVH) is the most common type of intracranial hemorrhage observed in preterm neonates. It is a precursor of poor neurocognitive development, cerebral palsy, and death. The pathophysiology is not well defined, but damage to the fragile germinal matrix vasculature may be due to free radicals generated during inflammation and as a consequence of ischemia followed by reperfusion. Assessment of the oxidative stress status in these infants is therefore important. Urinary allantoin concentration was measured in preterm neonates as a marker of oxidative stress associated with IVH...
April 2016: Translational Stroke Research
Zhu-Wei Liang, Li Lin, Wan-Li Gao, Li-Min Feng
Intracerebral haemorrhage (ICH) occurring during pregnancy and the puerperium is an infrequent but severe complication with a high mortality and poor prognosis. Until recently, previous studies have mainly focused on the effect of different treatments on prognosis. However, few studies have provided solid evidence to clarify the key predisposing factors affecting the prognosis of ICH. In the present study, based on a unique sample with a high ICH incidence and mortality rate, we described the main clinical characteristics of ICH patients and found that the prognosis of patients who underwent surgical intervention was not better than that of patients who received other treatment modalities...
2015: Scientific Reports
Hua Wang, Li-Zhong Du, Jun Tang, Jin-Lin Wu, De-Zhi Mu
OBJECTIVE: To investigate the clinical efficacy and safety of preferred use of high-frequency oscillatory ventilation (HFOV) in the treatment of neonatal pulmonary hemorrhage. METHODS: The clinical efficacy of preferred use of HFOV (preferred use group) and rescue use of HFOV after conventional mechanical ventilation proved ineffective (rescue use group) in the treatment of 26 cases of neonatal pulmonary hemorrhage was retrospectively analyzed. The oxygenation index (OI), pulmonary hemorrhage time, hospitalization time, ventilation time, oxygen therapy time, complications, and outcome of the two groups were compared...
March 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Eran Barzilay, Shali Mazaki-Tovi, Uri Amikam, Hila de Castro, Jigal Haas, Ram Mazkereth, Eyal Sivan, Eyal Schiff, Yoav Yinon
OBJECTIVE: The purpose of this study was to determine whether planned vaginal delivery is associated with increased risk of perinatal death and morbidity in twin pregnancies that are complicated by a very low birthweight of the second twin. STUDY DESIGN: We conducted a retrospective cohort study of twin pregnancies in which the second twin's birthweight was ≤1500 g. One hundred ninety-three twin gestations met the study criteria; patients were classified into 2 groups according to the planned mode of delivery: (1) cesarean delivery (n = 142) and (2) vaginal delivery (n = 51)...
August 2015: American Journal of Obstetrics and Gynecology
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