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Red blood cell antigen

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https://www.readbyqxmd.com/read/28719385/prevention-of-hemolytic-disease-of-the-fetus-and-newborn-what-have-we-learned-from-animal-models
#1
Yoelys Cruz-Leal, Danielle Marjoram, Alan H Lazarus
PURPOSE OF REVIEW: This review aims to highlight recent advances in our understanding of how anti-red blood cell (RBC) antibodies prevent erythrocyte immunization with an emphasis on new murine models. RECENT FINDINGS: New murine models with clinically relevant human erythrocyte antigens have been used to understand the alloimmunization process and its inhibition. The search to elucidate the mechanism of action of IgG-mediated inhibition of erythrocyte alloimmunization has provided new evidence in support of a potential role for epitope masking, immune deviation and/or antigen modulation in this process...
July 20, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28718464/-dissertation-25-years-after-date-48-the-effect-of-saliva-on-the-colonisation-of-oral-bacteria
#2
A J M Ligtenberg
In the research that formed the basis of the dissertation 'Intervention of saliva in the colonization process of oral bacteria' from 1992, the aggregation or clustering of oral bacteria by saliva was investigated. This prevents bacterial colonisation in the mouth. Major individual differences in aggregation activity of different saliva samples were found to exist, partly determined by the blood group of the saliva donor. As well as being found in red blood cells, AB0 blood group antigens also appear on salivary glycoproteins...
July 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28717357/high-levels-of-cxcl8-and-low-levels-of-cxcl9-and-cxcl10-in-women-with-maternal-rhd-alloimmunization
#3
Juliana Araújo de Carvalho Schettini, Thomás Virgílio Gomes, Alexandra Karla Santos Barreto, Claudeir Dias da Silva Júnior, Marina da Matta, Isabela Cristina Neiva Coutinho, Maria do Carmo Valgueiro Costa de Oliveira, Leuridan Cavalcante Torres
Maternal RhD alloimmunization is an inflammatory response against protein antigens in fetal red blood cells (RBC). However, not all women become alloimmunized when exposed to RhD(+) fetal RBC. Thus, this study aimed to evaluate levels of inflammatory chemokines in RhD(-) pregnant women with erythrocyte alloimmunization. CXCL8, CXCL9, CCL5, and CXCL10 levels were determined from cell culture supernatants by flow cytometry in 46 (30 non-alloimmunized RhD(-) and 16 previously alloimmunized RhD(-)) pregnant women...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28698207/strict-tropism-for-cd71-cd234-human-reticulocytes-limits-plasmodium-cynomolgi-s-zoonotic-potential
#4
Varakorn Kosaisavee, Rossarin Suwanarusk, Adeline C Y Chua, Dennis E Kyle, Benoit Malleret, Rou Zhang, Mallika Imwong, Rawiwan Imerbsin, Ratawan Ubalee, Hugo Sámano-Sánchez, Bryan K S Yeung, Jessica Ong, Eric Lombardini, François Nosten, Kevin S W Tan, Pablo Bifani, Georges Snounou, Laurent Rénia, Bruce Russell
Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P. cynomolgi, can infect humans experimentally. In Malaysia, where both species are common, zoonotic knowlesi malaria has recently become dominant, and cases are recorded throughout the region. By contrast, to date only a single case of naturally acquired P. cynomolgi has been found in humans. In this study we show that whereas P. cynomolgi merozoites invade monkey red blood cells (RBCs) indiscriminately in vitro, for humans they are restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy antigen/chemokine receptor (DARC or CD234)...
July 11, 2017: Blood
https://www.readbyqxmd.com/read/28686149/enhanced-opsonisation-of-rhesus-d-positive-human-red-blood-cells-by-recombinant-polymeric-immunoglobulin-g-anti-g-antibodies
#5
Dylana Díaz-Solano, Jaheli Fuenmayor, Ramon F Montaño
BACKGROUND: Anti-RhD antibodies (anti-D) are important in the prophylaxis of haemolytic disease of the foetus and newborn (HDFN) due to RhD incompatibility. Current preparations of anti-D are sourced from hyperimmune human plasma, so its production carries a risk of disease and is dependent on donor availability. Despite the efforts to develop a monoclonal preparation with similar prophylactic properties to the plasma-derived anti-D, no such antibody is yet available. Here we studied the agglutinating, opsonic and haemolytic activities of two recombinant polymeric immunoglobulins (Ig) against the G antigen of the Rh complex...
May 30, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28680086/host-age-and-expression-of-genes-involved-in-red-blood-cell-invasion-in-plasmodium-falciparum-field-isolates
#6
Aida Valmaseda, Quique Bassat, Pedro Aide, Pau Cisteró, Alfons Jiménez, Aina Casellas, Sonia Machevo, Ruth Aguilar, Betuel Sigaúque, Virander S Chauhan, Christine Langer, James Beeson, Chetan Chitnis, Pedro L Alonso, Deepak Gaur, Alfredo Mayor
Plasmodium falciparum proteins involved in erythrocyte invasion are main targets of acquired immunity and important vaccine candidates. We hypothesized that anti-parasite immunity acquired upon exposure would limit invasion-related gene (IRG) expression and affect the clinical impact of the infection. 11 IRG transcript levels were measured in P. falciparum isolates by RT-PCR, and IgG/IgM against invasion ligands by Luminex®, in 50 Mozambican adults, 25 children with severe malaria (SM) and 25 with uncomplicated malaria (UM)...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679662/measuring-the-plasmodium-falciparum-hrp2-protein-in-blood-from-artesunate-treated-malaria-patients-predicts-post-artesunate-delayed-hemolysis
#7
Papa Alioune Ndour, Sébastien Larréché, Oussama Mouri, Nicolas Argy, Frédérick Gay, Camille Roussel, Stéphane Jauréguiberry, Claire Perillaud, Dominique Langui, Sylvestre Biligui, Nathalie Chartrel, Audrey Mérens, Eric Kendjo, Aniruddha Ghose, Md Mahtab Uddin Hassan, Md Amir Hossain, Hugh W F Kingston, Katherine Plewes, Arjen M Dondorp, Martin Danis, Sandrine Houzé, Serge Bonnefoy, Marc Thellier, Charles J Woodrow, Pierre A Buffet
Artesunate, the recommended drug for severe malaria, rapidly clears the malaria parasite from infected patients but frequently induces anemia-called post-artesunate delayed hemolysis (PADH)-for which a simple predictive test is urgently needed. The underlying event in PADH is the expulsion of artesunate-exposed parasites from their host erythrocytes by pitting. We show that the histidine-rich protein 2 (HRP2) of the malaria parasite Plasmodium falciparum persists in the circulation of artesunate-treated malaria patients in Bangladesh and in French travelers who became infected with malaria in Africa...
July 5, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28669524/from-genetic-variability-to-phenotypic-expression-of-blood-group-systems
#8
L Raud, C Férec, Y Fichou
More than 300 red blood cell (RBC) antigens belonging to 36 blood group systems have been officially reported in humans by the International Society of Blood Transfusion (ISBT). Phenotypic variability is directly linked to the expression of the 41 blood group genes. The Rh blood group system, which is composed of 54 antigens, is the most complex and polymorphic system. Many rare genetic variants within the RH (RHD and RHCE) genes, involving various mutational mechanisms (single-nucleotide substitutions, short insertions/deletions, rearrangements, large deletions), have been reported in the literature and reference databases...
June 29, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28668608/babesia-bovis-bov57-a-theileria-parva-p67-homolog-is-an-invasion-related-neutralization-sensitive-antigen
#9
Takahiro Ishizaki, Thillaiampalam Sivakumar, Kyoko Hayashida, Hitoshi Takemae, Bumduuren Tuvshintulga, Tserendorj Munkhjargal, Azirwan Guswanto, Ikuo Igarashi, Naoaki Yokoyama
Babesia bovis BOV57, which is a homolog of the Theileria parva vaccine candidate antigen P67, is expressed in both the tick and blood stages of the life cycle of this parasite. However, the vaccine potential of BOV57 remained to be investigated. In the present study, we generated recombinant BOV57 (rBOV57) and prepared polyclonal antibodies against rBOV57 in mice and rabbits. Indirect immunofluorescence assays conducted with the mouse anti-rBOV57 antibody demonstrated that BOV57 localized at the apical end of paired merozoites in infected bovine red blood cells, whereas the antigen was found in the parasite membrane around the apical end of intraerythrocytic single and extracellular merozoites...
June 28, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28668325/igg-opsonization-of-merozoites-multiple-immune-mechanisms-for-malaria-vaccine-development
#10
REVIEW
Danika L Hill, Louis Schofield, Danny W Wilson
Global eradication of the human-infecting malaria parasite Plasmodium falciparum, the major cause of malaria mortality, is unlikely to be achieved without an effective vaccine. However, our limited understanding of how protective immune responses target malaria parasites in humans, and how to best elicit these immune responses through vaccination, has hampered vaccine development. The red blood cell invading stage of the parasite lifecycle (merozoite) displays antigens that are attractive vaccine candidates as they are accessible to antibodies and raise high antibody titres in naturally immune individuals...
June 29, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28664822/passenger-lymphocyte-syndrome-in-the-abo-incompatible-kidney-transplant-recipient-receiving-rituximab
#11
Shunji Nishide, Junji Uchida, Kazuya Kabei, Tomoaki Iwai, Nobuyuki Kuwabara, Toshihide Naganuma, Norihiko Kumada, Yoshiaki Takemoto, Tatsuya Nakatani
Passenger lymphocyte syndrome is a rare but important disease in which the donor lymphocytes produce antibodies to the red blood cell antigens of the recipient, causing alloimmune hemolysis. It occurs in ABO blood group-mismatched solid-organ and/or bone marrow transplant. We report a case of passenger lymphocyte syndrome occurring after ABO-incompatible kidney transplant. The recipient received rituximab as a desensitization protocol. On posttransplant day 18, the recipient showed a fall in her hemoglobin levels without identifiable bleeding source and an elevation of total bilirubin...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28662088/automated-interpretation-of-influenza-hemagglutination-inhibition-hai-assays-is-plate-tilting-necessary
#12
Garrett Wilson, Zhiping Ye, Hang Xie, Steven Vahl, Erica Dawson, Kathy Rowlen
The hemagglutination inhibition assay (HAI) is widely used to evaluate vaccine-induced antibody responses as well as to antigenically characterize influenza viruses. The results of an HAI assay are based on an endpoint titration where the titers are generally manually interpreted and recorded by a well-trained expert. For serological applications, the lack of standardization in endpoint interpretation and interference from non-specific inhibitors in clinical samples can translate into a high degree of variability in the results...
2017: PloS One
https://www.readbyqxmd.com/read/28657767/recognizing-and-resolving-abo-discrepancies
#13
Geralyn M Meny
Patient samples are routinely typed for ABO prior to transfusion. Determining the ABO group requires both red blood cell (RBC) antigen typing for A and B (forward type) and testing for anti-A and anti-B in the plasma (reverse type). An ABO discrepancy exists when the result of an ABO RBC typing, or forward type, does not agree with the result of the plasma typing, or reverse type. This brief review examines several causes of ABO discrepancies encountered in the clinical transfusion service. Options for resolving these discrepancies are presented, including a discussion of which discrepancies should be resolved using molecular testing...
June 2017: Immunohematology
https://www.readbyqxmd.com/read/28657766/a-suspected-delayed-hemolytic-transfusion-reaction-mediated-by-anti-joa
#14
Ryan P Jajosky, Wendy C Lumm, Scott C Wise, Roni J Bollag, James F Shikle
A 32-year-old African-American woman with a history of sickle cell disease presented for surgical evaluation of left total hip arthroplasty due to avascular necrosis of the femoral head. In anticipation of a complex orthopedic procedure, pre-surgical blood work was ordered. The patient's Fenwal blood sample typed as group O, D+. Although the patient had a history of anti-Fya, the antibody identification was inconclusive, so the workup was sent to a reference laboratory. The patient was last transfused with red blood cells (RBCs) 2 years earlier, but had no history of transfusion reactions...
June 2017: Immunohematology
https://www.readbyqxmd.com/read/28657765/the-fors-awakens-review-of-a-blood-group-system-reborn
#15
Annika K Hult, Martin L Olsson
The presence of the FORS1 antigen on red blood cells was discovered relatively recently, and in 2012, the International Society of Blood Transfusion (ISBT) acknowledged FORS as blood group system number 031. This rare antigen is carried by a glycosphingolipid and formed by elongation of the P antigen. Most people have naturally occurring anti-FORS1 in their plasma. The clinical significance of these antibodies is unknown in the transfusion setting, but they can hemolyze FORS1+ erythrocytes in the presence of complement in vitro...
June 2017: Immunohematology
https://www.readbyqxmd.com/read/28657763/the-vel-blood-group-system-a-review
#16
Jill R Storry, Thierry Peyrard
The blood group antigen Vel has been one of immunohematology's greatest enigmas: the variation in antigen strength from one individual to another, the property of anti-Vel to readily hemolyze Vel+ red blood cells (RBCs), and the difficulty to screen for sufficient numbers of Vel- blood donors had made Vel a tough nut to crack. In 2013, a small, previously unknown protein called small integral membrane protein 1 (SMIM1) was identified on the RBC by three independent research groups using different approaches, and all three groups demonstrated that Vel- RBCs lacked SMIM1...
June 2017: Immunohematology
https://www.readbyqxmd.com/read/28655551/adult-venous-endothelium-is-a-niche-for-highly-proliferative-and-vasculogenic-endothelial-colony-forming-cells
#17
Linden Green, Richard H Ofstein, Brian Rapp, M Reza Saadatzadeh, Janak R Bhavsar, Andres Fajardo, Michael C Dalsing, David A Ingram, Michael P Murphy
OBJECTIVE: Postnatal resident endothelium of blood vessels has been proposed to represent terminally differentiated tissue that does not replicate. We previously isolated endothelial colony-forming cells (ECFCs) from human umbilical cord blood (CB) and term placenta by using colony-forming assays and immunocytochemistry. We showed that ECFCs are highly proliferative and form functioning vessels in vivo, the defining characteristics of a true endothelial progenitor cell. This exploratory investigation was conducted to determine whether the endothelium of healthy adult blood vessels contained resident ECFCs...
June 24, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28653406/an-exonic-missense-mutation-c-28g-a-is-associated-with-weak-b-blood-group-by-affecting-rna-splicing-of-the-abo-gene
#18
Xiaohong Cai, Chengrui Qian, Wenman Wu, Hang Lei, Qiulan Ding, Wei Zou, Dong Xiang, Xuefeng Wang
BACKGROUND: The amino acid substitutions caused by ABO gene mutations are usually predicted to impact glycosyltransferase's function or its biosynthesis. Here we report an ABO exonic missense mutation that affects B-antigen expression by decreasing the mRNA level of the ABO gene rather than the amino acid change. STUDY DESIGN AND METHODS: Serologic studies including plasma total GTB transfer capacity were performed. The exon sequences of the ABO gene were analyzed by Sanger sequencing...
June 26, 2017: Transfusion
https://www.readbyqxmd.com/read/28653329/acquired-rhd-mosaicism-identifies-fibrotic-transformation-of-thrombopoietin-receptor-mutated-essential-thrombocythemia
#19
Celina Montemayor-Garcia, Rebecca Coward, Maher Albitar, Rupa Udani, Prachi Jain, Eleftheria Koklanaris, Minoo Battiwalla, Siobán Keel, Harvey G Klein, A John Barrett, Sawa Ito
BACKGROUND: Acquired copy-neutral loss of heterozygosity has been described in myeloid malignant progression with an otherwise normal karyotype. CASE REPORT: A 65-year-old woman with MPL-mutated essential thrombocythemia and progression to myelofibrosis was noted upon routine pretransplant testing to have mixed field reactivity with anti-D and an historic discrepancy in RhD type. The patient had never received transfusions or transplantation. RESULTS: Gel immunoagglutination revealed group A red blood cells and a mixed-field reaction for the D phenotype, with a predominant D-negative population and a small subset of circulating red blood cells carrying the D antigen...
June 26, 2017: Transfusion
https://www.readbyqxmd.com/read/28651884/-transfusions-in-myelodysplastic-syndromes
#20
C Rose
PRBC transfusion remains the mainstay of treatment of anemia in MDS after failure of erythropoiesis stimulating agents. The most common transfusion trigger in transfusion-dependent MDS patients is 80g/L. This level is based only on expert consensus; a randomized controlled trial comparing restrictive against liberal policy is required to evaluate potential impact of transfusion policy on with QoL and survival. Prophylactic antigen matching for RhCE and K must be used in order to reduce the risk of red blood cell (RBC) alloimmunization...
June 23, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
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