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Red blood cell antigen

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https://www.readbyqxmd.com/read/29469208/molecular-characterization-and-multidisciplinary-management-of-gerbich-hemolytic-disease-of-the-newborn
#1
Rebecca N Levitt, Elise Gourri, Christoph Gassner, Grace Banez-Sese, Abdus Salam, Gregory A Denomme, Elizabeth Yang
Gerbich (Ge) antigens are high frequency red cell antigens expressed on glycophorin C (GYPC) and glycophorin D. Hemolytic disease of the fetus and newborn (HDFN) due to Gerbich antibody is rare and presents a clinical challenge, as Gerbich negative blood is scarce. We report a case of HDFN due to maternal Ge3 negative phenotype and anti-Ge3 alloimmunization, successfully managed by transfusion of maternal blood. Molecular testing revealed that the mother has homozygous deletion of exon 3 of GYPC, the father is homozygous wildtype for GYPC, and the infant is obligate heterozygote expressing Ge3...
February 22, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29464723/a-unique-major-histocompatibility-complex-class-ii-binding-register-correlates-with-hla-dr11-associated-immunogenicity-of-the-major-k-blood-group-antigen
#2
Devi Gunasekera, James C Zimring, Kathleen P Pratt
BACKGROUND: Kell is a glycoprotein expressed on red blood cells (RBCs). Its K and k variants contain either Met (K antigen) or Thr (k antigen) at Position 193, respectively. Development of anti-K after K-mismatched antigen exposure via blood transfusions or pregnancy can destroy RBCs, leading to hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. The immunogenicity of overlapping 15-mer Kell peptides with M193 or T193 at every possible position was investigated previously...
February 20, 2018: Transfusion
https://www.readbyqxmd.com/read/29446013/chronic-graft-specific-cell-mediated-immune-response-toward-candidate-xenogeneic-biomaterial
#3
Katherine V Gates, Leigh G Griffiths
Despite rabbits becoming an increasingly popular animal model, a flow cytometry panel that combines T cell markers (CD3, CD4, CD8, CD25, FOXP3) with a method for monitoring proliferation is lacking in this species. It has been shown that the rabbit model can be used to identify xenoantigens within bovine pericardium (BP), a common biological heart valve replacement material; however, these methods rely on monitoring the humoral immune response. The development of a rabbit T cell proliferation assay has utility in monitoring graft-specific cell-mediated immune responses toward bovine pericardium...
February 14, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29445378/fc-glycosylation-in-human-igg1-and-igg3-is-similar-for-both-total-and-anti-red-blood-cell-anti-k-antibodies
#4
Myrthe E Sonneveld, Carolien A M Koeleman, H Rosina Plomp, Manfred Wuhrer, C Ellen van der Schoot, Gestur Vidarsson
After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. The quality of the IgG-Fc-glycosylation has important functional consequences, which have been found to be skewed toward low fucosylation in some antigen-specific immune responses. This increases the affinity to IgG1-Fc-receptor (FcγR)IIIa/b and thereby directly affects downstream effector functions and disease severity. To date, antigen-specific IgG-glycosylation have not been analyzed for IgG3...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29441590/the-prevalence-immunogenicity-and-evanescence-of-alloantibodies-to-mut-and-mur-antigens-of-gp-mur-red-blood-cells-in-a-southeast-asian-patient-cohort
#5
Veera Sekaran Nadarajan
BACKGROUND: Antibodies to Mi a , MUT, and Mur are among the most frequently identified alloantibodies in Southeast Asia. Understanding the characteristics of these antibodies in terms of induction and evanescence would aid in optimizing methods for their detection. STUDY DESIGN AND METHODS: Antibody testing results between the years 2013 and 2015 with relevant patient demographic data and red blood cell (RBC) transfusion history were retrieved. Cumulative alloimmunization incidence and evanescence to MUT and Mur were estimated by Kaplan-Meier analysis in relation to the number of RBC units transfused and time...
February 13, 2018: Transfusion
https://www.readbyqxmd.com/read/29435077/clinical-value-of-the-preoperative-neutrophil-to-lymphocyte-ratio-and-red-blood-cell-distribution-width-in-patients-with-colorectal-carcinoma
#6
Fuyan Han, Xuming Shang, Furong Wan, Zhanfeng Liu, Wenjun Tian, Dan Wang, Yiqing Liu, Yong Wang, Bingchang Zhang, Ying Ju
The aim of the present study was to investigate the clinical value of the preoperative neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) in the peripheral blood of colorectal carcinoma (CRC) patients. Clinical data obtained from 240 patients with CRC undergoing radical surgical resection in Shandong Provincial Hospital Affiliated to Shandong University (Jinan, Shandong, China) between January 2011 and April 2015 were retrospectively analyzed. Data were also collected from 110 patients with colon polyps and 48 healthy volunteers to serve as controls for comparative analysis...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29422913/identifying-potential-plasmodium-vivax-sporozoite-stage-vaccine-candidates-an-analysis-of-genetic-diversity-and-natural-selection
#7
Diego Garzón-Ospina, Sindy P Buitrago, Andrea E Ramos, Manuel A Patarroyo
Parasite antigen genetic diversity represents a great obstacle when designing a vaccine against malaria caused by Plasmodium vivax. Selecting vaccine candidate antigens has been focused on those fulfilling a role in invasion and which are conserved, thus avoiding specific-allele immune responses. Most antigens described to date belong to the blood stage, thereby blocking parasite development within red blood cells, whilst studying antigens from other stages has been quite restricted. Antigens from different parasite stages are required for developing a completely effective vaccine; thus, pre-erythrocyte stage antigens able to block the first line of infection becoming established should also be taken into account...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29406082/survival-time-and-effect-of-selected-predictor-variables-on-survival-in-owned-pet-cats-seropositive-for-feline-immunodeficiency-and-leukemia-virus-attending-a-referral-clinic-in-northern-italy
#8
Eva Spada, Roberta Perego, Elena Assunta Sgamma, Daniela Proverbio
Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are among the most important feline infectious diseases worldwide. This retrospective study investigated survival times and effects of selected predictor factors on survival time in a population of owned pet cats in Northern Italy testing positive for the presence of FIV antibodies and FeLV antigen. One hundred and three retrovirus-seropositive cats, 53 FIV-seropositive cats, 40 FeLV-seropositive cats, and 10 FIV+FeLV-seropositive cats were included in the study...
February 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29392728/soluble-antigens-in-plasma-allow-mismatched-transfusion-without-hemolysis
#9
James Sikora, Jason Gregory, Alan George, Simon Clayton, Baiming Zou, Matthew Robinson, Faisal Mukhtar, Joseph P Pelletier
BACKGROUND: Universal plasma is a scarce resource when a massive transfusion protocol has been initiated. Previous studies have reported success using group A plasma in place of the universal plasma, group AB. It is unclear why there are not more reports of hemolytic reactions occurring from this practice. One possible explanation is the presence of water-soluble antigens in the patient plasma that bind to, and neutralize, the soluble antibodies present in the transfused plasma. STUDY DESIGN AND METHODS: Expired units of plasma were used to make dilutions that consisted of mixtures of group A and B plasma and saline...
February 1, 2018: Transfusion
https://www.readbyqxmd.com/read/29386549/comparison-of-a-pcr-assay-using-novel-selective-primers-with-current-methods-in-terms-of-abo-blood-phenotyping-in-rhesus-macaques
#10
Yun-Jung Choi, Rae Hyung Ryu, Hye-Jin Park, Jae-Il Lee
Nonhuman primates are important animal models in transplantation. To prevent fatal transplantation-induced immune responses, it is necessary to accurately phenotype the monkey ABH antigens, which are the same as those in humans but (unlike in humans) are not expressed on red blood cells (RBCs). We compared the ability of two established ABO-typing methods, namely, serological testing and immunohistochemistry (IHC), and our novel polymerase chain reaction (PCR)-based assay to type 66 rhesus monkeys. The serological test assessed the ability of monkey sera to hemagglutinate human RBCs...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29380052/immune-challenges-decrease-biliverdin-concentration-in-the-spleen-of-northern-bobwhite-quail-colinus-virginianus
#11
Melissa P Homsher, Michael T Astor, Justin K Hines, Michael W Butler
Most antioxidants have multiple functions; in addition to minimizing oxidative damage, many antioxidants have immune-modulating properties. For example, biliverdin is produced in the liver and spleen from the breakdown of heme, and has putative immune-suppressing and antioxidant properties. However, the majority of these properties have been investigated in vitro or in mammalian models, in which biliverdin reductase converts virtually all biliverdin to bilirubin. Thus, biliverdin's physiological roles remain largely untested...
January 29, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29378150/dithiothreitol-treatment-of-red-blood-cells
#12
Carolina B Bub
Dithiothreitol (DTT), a reducing reagent, has multiple applications in blood bank testing. DTT disrupts the bridging of the disulfide bonds between amino acid residues necessary for structural conformation of some proteins and the bonds holding an IgM molecule in the pentameric formation. DTT treatment of red blood cells (RBCs) can denature or modify certain blood group antigens-in particular, those in the Kell, Lutheran, YT, JMH, LW, Cromer, Indian, Dombrock, and Knops systems-and prevent recognition by the corresponding antibodies...
December 2017: Immunohematology
https://www.readbyqxmd.com/read/29378146/anti-vel-alloimmunization-and-severe-hemolytic-disease-of-the-fetus-and-newborn
#13
Kenneth J Moise, Yisel Morales, Marsha F Bertholf, Susan N Rossmann, Yu Bai
Only rare cases of anti-Vel-associated mild-to-moderate hemolytic disease of the fetus and newborn have been previously reported. No case of fetal anemia requiring prenatal therapy has been noted to date. We report such a case recently encountered at our Fetal Center. Strategies are discussed for managing pregnancy complicated with alloimmunization to an antibody to a high-prevalence antigen, including sources of red blood cells for intrauterine transfusions.
December 2017: Immunohematology
https://www.readbyqxmd.com/read/29378145/assessment-of-common-red-blood-cell-pretreatments-to-yield-an-accurate-serologic-antigen-phenotype-compared-with-genotypepredicted-phenotype
#14
Trina Horn, Janis Hamilton, Joanne Kosanke, Virginia W Hare, Wendy Kluver, Wendy Beres, Sandra Nance, Margaret A Keller
For patients requiring multiple transfusions and patients with positive direct antiglobulin tests (DATs), an extended red blood cell (RBC) phenotype can provide valuable information and help to determine the risk of forming alloantibodies. In some instances, the phenotype may be used for prophylactic matching. Phenotyping in this patient population is often hindered by the presence of circulating donor cells and/or by a positive DAT. Several methods, such as EDTA glycine acid (EGA) treatment to remove IgG, hypotonic saline wash to separate autologous RBCs, or reticulocyte separation, are often used in these situations to isolate patient RBCs for serologic phenotyping...
December 2017: Immunohematology
https://www.readbyqxmd.com/read/29365318/recipient-priming-to-one-rbc-alloantigen-directly-enhances-subsequent-alloimmunization-in-mice
#15
Seema R Patel, Ashley Bennett, Kathryn Girard-Pierce, Cheryl L Maier, Satheesh Chonat, Connie M Arthur, Patricia E Zerra, Amanda Mener, Sean R Stowell
Individuals that become immunized to red blood cell (RBC) alloantigens can experience an increased rate of antibody formation to additional RBC alloantigens following subsequent transfusion. Despite this, how an immune response to one RBC immunogen may impact subsequent alloimmunization to a completely different RBC alloantigen remains unknown. Our studies demonstrate that Kell blood group antigen (KEL) RBC transfusion in the presence of inflammation induced by poly (I:C) (PIC) not only enhances anti-KEL antibody production through a CD4+ T-cell-dependent process but also directly facilitates anti-HOD antibody formation following subsequent exposure to the disparate HOD (hen egg lysozyme, ovalbumin, fused to human blood group antigen Duffy b) antigen...
January 23, 2018: Blood Advances
https://www.readbyqxmd.com/read/29337673/evaluation-of-immunomodulatory-effects-of-lamotrigine-in-balb-c-mice
#16
Eman Y Abu-Rish, Shada Y Elhayek, Yehia S Mohamed, Islam Hamad, Yasser Bustanji
Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy. Therefore, the most recent guidelines for immunotoxicological evaluation of drugs were consulted to investigate the immunomodulatory effects of lamotrigine, a newer antiepileptic drug, in BALB/c mice. These included the in vivo effects of lamotrigine on delayed-type hypersensitivity (DTH) response to sheep red blood cell (SRBC) antigens, hemagglutination titer assays and hematological changes...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29330014/frequency-of-red-blood-cell-genotypes-in-multi-transfused-patients-and-blood-donors-from-minas-gerais-southeast-brazil
#17
Vitor Mendonça Alves, Fernanda Bernadelli De Vito, Paulo Roberto Juliano Martins, Sheila Soares Silva, Lilian Castilho, Helio Moraes-Souza
BACKGROUND AND OBJECTIVES: The frequency of red blood cell (RBC) antigens in Brazil varies due to differences in the ethnic groups in different regions; however, these studies have not been performed in Minas Gerais, where African admixture is more prevalent in comparison with other states. Due to these facts, this study aimed to determine the frequency of RBC genotypes on Rh, Kell, Duffy and Kidd systems in blood donors and multi-transfused patients from Minas Gerais, Southeast Brazil...
December 16, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29325918/bioactive-fraction-of-rhodiola-algida-against-chronic-hypoxia-induced-pulmonary-arterial-hypertension-and-its-anti-proliferation-mechanism-in-rats
#18
Xingmei Nan, Shanshan Su, Ke Ma, Xiaodong Ma, Ximeng Wang, Dongzhu Zhaxi, Rili Ge, Zhanqiang Li, Dianxiang Lu
BACKGROUND: Rhodiola algida has long been used to prevent acute and chronic altitude sickness. In our previous study, we screened for a bioactive fraction from R. algida. However, the effects and mechanisms of this bioactive fraction on chronic hypoxia-induced pulmonary arterial hypertension remain to be elucidated. OBJECTIVE: The aim of this study was to determine the effect of bioactive fraction from R. algida (ACRT) on chronic hypoxia-induced pulmonary arterial hypertension (HPAH) and to understand the possible mechanism of its pharmacodynamic actions...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29322074/data-supporting-the-understanding-of-modulatory-function-of-opioid-analgesics-in-mouse-macrophage-activity
#19
Iwona Filipczak-Bryniarska, Katarzyna Nazimek, Bernadeta Nowak, Michael Kozlowski, Magdalena Wąsik, Krzysztof Bryniarski
The data presented herein expand the current understanding of the modulatory function of opioid drugs in mouse macrophage activity described in our relevant research article (Filipczak-Bryniarska et al., 2017) [1], in which we characterize the influence of morphine, buprenorphine and oxycodone on humoral and cell-mediated immune response in mice. Among other things, we have shown the effects of treatment with assayed analgesics on macrophage ability to induce antigen-specific B-cell response to sheep red blood cells as well as to generate reactive oxygen intermediates and nitric oxide...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29299530/evidence-that-the-plasmodium-falciparum-protein-sortilin-potentially-acts-as-an-escorter-for-the-trafficking-of-the-rhoptry-associated-membrane-antigen-to-the-rhoptries
#20
Stéphanie Hallée, Justin A Boddey, Alan F Cowman, Dave Richard
The rhoptry organelle is critical for the invasion of an erythrocyte by the malaria parasite Plasmodium falciparum. Despite their critical roles, the mechanisms behind their biogenesis are still poorly defined. Our earlier work had suggested that the interaction between the glycosylphosphatidylinositol (GPI)-anchored rhoptry-associated membrane antigen (RAMA) and the soluble rhoptry-associated protein 1 was involved in the transport of the latter from the Golgi apparatus to the rhoptry. However, how this protein complex could interact with the intracellular trafficking machinery was unknown at this stage...
January 2018: MSphere
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