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Red blood cell antigen

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https://www.readbyqxmd.com/read/29240292/molecular-mechanism-for-the-red-blood-cell-senescence-clock
#1
REVIEW
Katherine E Badior, Joseph R Casey
Lacking protein synthesis machinery and organelles necessary for autophagy or apoptosis, aged red blood cells (RBCs) are marked by circulating auto-antibodies for macrophage-mediated clearance. The antigen recognized by these auto-antibodies is the major protein of the RBC membrane, Band 3. To ensure regulation and specificity in clearance, the molecular "clock" must mark senescent cells in a way that differentiates them from younger cells, to prevent premature clearance. Predominant models of Band 3 senescence signaling are reviewed, and merits are discussed in light of the recently published crystal structure of the Band 3 membrane domain...
December 14, 2017: IUBMB Life
https://www.readbyqxmd.com/read/29226260/a-novel-rapid-direct-haemagglutination-inhibition-assay-for-measurements-of-humoral-immune-response-against-non-haemagglutinating-fowlpox-virus-strains-in-vaccinated-chickens
#2
Philemon N Wambura, Alexanda Mzula
Fowlpox (FP) is a serious disease in chickens caused by Fowlpox virus (FPV). One method currently used to control FPV is vaccination followed by confirmation that antibody titres are protective using the indirect haemagglutination assay (IHA). The direct haemagglutination inhibition (HI) assay is not done because most FPV strains do not agglutinate chicken red blood cells (RBCs). A novel FPV strain TPV-1 which agglutinates chicken RBCs was discovered recently and enabled a direct HI assay to be conducted using homologous sera...
October 2017: Heliyon
https://www.readbyqxmd.com/read/29213331/noninvasive-prenatal-diagnosis-of-fetal-aneuploidy-by-circulating-fetal-nucleated-red-blood-cells-and-extravillous-trophoblasts-using-silicon-based-nanostructured-microfluidics
#3
Chung-Er Huang, Gwo-Chin Ma, Hei-Jen Jou, Wen-Hsiang Lin, Dong-Jay Lee, Yi-Shing Lin, Norman A Ginsberg, Hsin-Fu Chen, Frank Mau-Chung Chang, Ming Chen
Background: Noninvasive prenatal testing (NIPT) based on cell-free DNA in maternal circulation has been accepted worldwide by the clinical community since 2011 but limitations, such as maternal malignancy and fetoplacental mosaicism, preclude its full replacement of invasive prenatal diagnosis. We present a novel silicon-based nanostructured microfluidics platform named as "Cell Reveal™" to demonstrate the feasibility of capturing circulating fetal nucleated red blood cells (fnRBC) and extravillous cytotrophoblasts (EVT) for cell-based noninvasive prenatal diagnosis (cbNIPD)...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29211247/immunoproteomics-of-plasmodium-falciparum-infected-red-blood-cell-membrane-fractions
#4
Fernanda J Cabral, Luciana G Vianna, Marcia M Medeiros, Bianca Cechetto Carlos, Rosimeire D Martha, Nadia Maria Silva, Luiz Hildebrando P da Silva, Rodrigo G Stabeli, Gerhard Wunderlich
BACKGROUND: The surface of infected red blood cells (iRBCs) has been widely investigated because of the molecular complexity and pathogenesis mechanisms involved. Asymptomatic individuals are important in the field because they can perpetuate transmission as natural reservoirs and present a challenge for diagnosing malaria because of their low levels of circulating parasites. Recent studies of iRBC antibody recognition have shown that responses are quantitatively similar in symptomatic and asymptomatic infections, but no studies have characterised the plasmodial proteins targeted by this response...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29210083/a-novel-association-between-high-red-blood-cell-alloimmunization-rates-and-hereditary-hemorrhagic-telangiectasia
#5
Yan Zheng, Jeffrey Pollak, Katharine Henderson, Jeanne E Hendrickson, Christopher A Tormey
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder associated with multiple arteriovenous malformations. HHT patients may require red blood cell (RBC) transfusion due to spontaneous hemorrhage or surgical bleeding. Because HHT-associated hemorrhage often occurs in submucosa we hypothesized that RBC alloimmunization rates in HHT patients may be higher than those observed in other transfused patients and investigated this in a retrospective study. STUDY DESIGN AND METHODS: Eighty-five patients with HHT who were transfused at our tertiary care facility were identified...
December 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29203871/cp-and-cp-pgn-protect-mice-against-mrsa-infection-by-inducing-m1-macrophages
#6
Yang Zhang, Xiang-Xiang Li, Yuan Ma, Jie Xu, Li-Na Zhao, Xue-Feng Qian, Xian-Feng Zhang, Jin-Fang Shi, Qing-Zhen Han
Corynebacterium pyruviciproducens (C. pyruviciproducens, CP), as a newly discovered immunomodulator, has been confirmed to have a stronger immunoregulation than Propionibacterium acnes (P. acnes) of the traditional immune adjuvant, by previous experiments with model antigen ovalbumin and sheep red blood cells. Here, it was designed to assess its ability to resist methicillin-resistant Staphylococcus aureus (MRSA), since MRSA as a vital gram positive pathogen is characterized by high morbidity and mortality...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29194343/blood-mixing-upregulates-platelet-membrane-bound-cd40-ligand-expression-in-vitro-independent-of-abo-compatibility
#7
Go-Shine Huang, Mei-Hua Hu, Tso-Chou Lin, Yi-Chang Lin, Yi-Ting Tsai, Chih-Yuan Lin, Hung-Yen Ke, Xu-Zhi Zheng, Chien-Sung Tsai
Platelets play a central role in the inflammation response via CD40 ligand (CD40L) expression, which may lead to transfusion reactions. The precise role of platelet CD40L-mediated inflammation in transfusion reactions is unclear. Therefore, we assessed the effects of in vitro blood mixing on platelet CD40L expression. In addition, we examined the effect of ABO compatibility on CD40L expression. Donor packed red blood cells were acquired from a blood bank, and recipient blood was obtained from patients undergoing cardiac surgery and prepared as washed platelets...
November 30, 2017: Shock
https://www.readbyqxmd.com/read/29193117/the-development-of-d-antibodies-after-d-mismatched-kidney-transplantation-in-a-setting-of-reduced-immunosuppression
#8
Thomas H P M Habets, Joris Vanderlocht, Ron J M H E Straat, Tim C van Smaalen, Gerard M J Bos, Erik A Beckers, Maarten H L Christiaans, Yvonne M C Henskens
BACKGROUND: D antigens are not taken into account in the allocation of solid organs. Female transplant recipients with D antibodies as a consequence of D-mismatched kidney transplantation may develop hemolytic disease of the fetus and newborn in future pregnancies. We examined D antibody development in transplant recipients who received D-mismatched kidney transplantation in absence of D prophylaxis and in a setting of reduced immunosuppression. STUDY DESIGN AND METHODS: From 1993 until 2015, a total of 1355 kidney patients received transplantations in our center of whom 156 received a D-mismatched graft...
November 29, 2017: Transfusion
https://www.readbyqxmd.com/read/29188625/-identification-of-a-novel-abo-b-a-07-allele
#9
Hong Luo, Guangping Luo, Runqing Zhang, Chunyan Mo, Zhijian Liao
OBJECTIVE: To explore the molecular basis for a novel B(A) phenotype. METHODS: Genomic DNA was abstracted from peripheral blood sample from the proband. ABO genotyping were carried out with sequence specific primer PCR (PCR-SSP). Exons 6 and 7 of the ABO gene were amplified with PCR and sequenced. RESULTS: Anti-A serum could not be adsorbed or eluted by the donor's red blood cells, and no irregular antibodies were found in the plasma. PCR-SSP showed that the ABO genotype of the donor was ABO *B/O...
December 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29181137/transfusion-related-acute-lung-injury-trali-in-two-thalassaemia-patients-caused-by-the-same-multiparous-blood-donor
#10
Annita Kolnagou, Christina N Kontoghiorghe, George J Kontoghiorghes
We report two separate episodes of transfusion-related acute lung injury (TRALI) in two thalassaemia patients who received red blood cell transfusions from the same multiparous donor. Both cases had the same symptomatology and occurred within 60 minutes of transfusion. The patients presented dyspnoea, sweating, fatigue, dizziness, fever, and sense of losing consciousness. The chest x-ray showed a pulmonary oedema-like picture with both lungs filled with fluid. The patients were treated in the intensive therapy unit...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29163500/antibodies-to-senescent-antigen-and-c3-are-not-required-for-normal-red-blood-cell-lifespan-in-a-murine-model
#11
Krystalyn E Hudson, Karen de Wolski, Linda M Kapp, Amanda L Richards, Matthew J Schniederjan, James C Zimring
Red blood cells (RBCs) have a well-defined lifespan, indicating a mechanism by which senescent cells of a certain age are removed from circulation. However, the specifics by which senescent cells are recognized and removed are poorly understood. There are multiple competing hypotheses for this process, perhaps the most commonly cited is that senescent RBCs expose neoantigens [or senescent antigen(s)] that are then recognized by naturally occurring antibodies, which opsonize the senescent cells and result in clearance from circulation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163471/innate-b-1-b-cells-are-not-enriched-in-red-blood-cell-autoimmune-mice-importance-of-b-cell-receptor-transgenic-selection
#12
Amanda L Richards, Heather L Howie, Linda M Kapp, Jeanne E Hendrickson, James C Zimring, Krystalyn E Hudson
Autoimmune hemolytic anemia (AIHA) results from breakdown of humoral tolerance to RBC antigens. Past analyses of B-cell receptor transgenic (BCR-Tg) mice that recognize RBC autoantigens led to a paradigm in which autoreactive conventional B-2 B cells are deleted whereas extramedullary B-1 B cells escape deletion due to lack of exposure to RBCs. However, BCR-Tg mice utilized to shape the current paradigm were unable to undergo receptor editing or class-switching. Given the importance of receptor editing as mechanism to tolerize autoreactive B cells during central tolerance, we hypothesized that expansion of autoreactive B-1 B cells is a consequence of the inability of the autoreactive BCR to receptor edit...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29162636/quantitative-proteomic-profiling-reveals-novel-plasmodium-falciparum-surface-antigens-and-possible-vaccine-candidates
#13
Sandra K Nilsson Bark, Rushdy Ahmad, Kathleen Dantzler, Amanda K Lukens, Mariana De Niz, Matthew J Szucs, Xiaojing Jin, Joanne Cotton, Dietmar Hoffmann, Eva Bric-Furlong, Ray Oomen, Mark Parrington, Dan Milner, Daniel E Neafsey, Steven A Carr, Dyann F Wirth, Matthias Marti
Despite recent efforts towards control and elimination, malaria remains a major public health problem worldwide. Plasmodium falciparum resistance against artemisinin, used in front line combination drugs, is on the rise, and the only approved vaccine shows limited efficacy. Combinations of novel and tailored drug and vaccine interventions are required to maintain the momentum of the current malaria elimination program. Current evidence suggests that strain-transcendent protection against malaria infection can be achieved using whole organism vaccination or with a polyvalent vaccine covering multiple antigens or epitopes...
November 21, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29156611/immunodetection-of-porcine-red-blood-cell-containing-food-ingredients-using-a-porcine-hemoglobin-specific-monoclonal-antibody
#14
Jack A Ofori, Yun-Hwa P Hsieh
Monoclonal antibody (mAb) 24C12-E7 has been found to bind to a 12 kDa antigenic protein in the red blood cell (RBC) of porcine blood. The purpose of this study was to determine the identity of this 12 kDa protein and consequently examine its potential as a marker for monitoring porcine RBC-containing ingredients (PRBCIs) in foods. Proteomic techniques identified the 12 kDa antigenic protein to be a monomer of the tetrameric hemoglobin molecule. Further heat-processing of spray-dried PRBCIs diminishes its detectability...
November 20, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29153948/rh-blood-phenotyping-d-e-e-c-c-microarrays-using-multichannel-surface-plasmon-resonance-imaging
#15
Chinnawut Pipatpanukul, Sasaki Takeya, Akira Baba, Ratthasart Amarit, Armote Somboonkaew, Boonsong Sutapun, Pimpun Kitpoka, Mongkol Kunakorn, Toemsak Srikhirin
The application of Surface Plasmon Resonance Imaging (SPRi) for the detection of transmembrane antigen of the Rhesus (Rh) blood group system is demonstrated. Clinically significant Rh blood group system antigens, including D, C, E, c, and e, can be simultaneously identified via solid phase immobilization assay, which offers significant time savings and assay simplification. Red blood cells (RBCs) flowed through the micro-channel, where a suitable condition for Rh blood group detection was an RBC dilution of 1:10 with a stop-flow condition...
November 2, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29150101/lack-of-association-between-kidd-blood-group-system-and-chronic-kidney-disease
#16
Tiago Verri Capriolli, Jeane Eliete Laguila Visentainer, Ana Maria Sell
BACKGROUND: The Kidd blood group system has three antigens, Jk(a), Jk(b) and Jk3, found on red blood cells and on endothelial cells of the inner lining of blood vessels in the renal medulla. These are known as urea transporter B (UT-B). Researchers have found that individuals carrying the Jk(a-b-) or Jk-null (UT-B null) phenotypes have a lower urine-concentrating capability and risk of severe renal impairment. This study evaluated the distribution of the Kidd phenotypes in patients with chronic kidney disease and a possible association of Kidd antigens with the development of renal disease...
October 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29145844/development-and-evaluation-of-an-interferon-gamma-assay-for-the-diagnosis-of-tuberculosis-in-red-deer-experimentally-infected-with-mycobacterium-bovis
#17
María Ángeles Risalde, Jobin Thomas, Iker Sevilla, Miriam Serrano, Jose Antonio Ortíz, Joseba Garrido, Mercedes Domínguez, Lucas Domínguez, Christian Gortázar, Jose Francisco Ruíz-Fons
BACKGROUND: Red deer (Cervus elaphus) is regarded as an epidemiologically relevant host for Mycobacterium bovis (M. bovis) and closely related members of the Mycobacterium tuberculosis complex that cause animal tuberculosis (TB). The standard antemortem screening test for the detection of TB in deer is the intradermal tuberculin skin test, but the detection of interferon-gamma (IFNγ) produced by white blood cells exposed to M. bovis antigens can be used as an alternative or supplemental assay in most TB eradication/control programs...
November 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29117566/cytosolic-recognition-of-rna-drives-the-immune-response-to-heterologous-erythrocytes
#18
Claudia Loetsch, Joanna Warren, Adrienne Laskowski, Rodrigo Vazquez-Lombardi, Christoph Jandl, David B Langley, Daniel Christ, David R Thorburn, David K Ryugo, Jonathan Sprent, Marcel Batten, Cecile King
The archetypal T cell-dependent antigen is sheep red blood cells (SRBCs), which have defined much of what we know about humoral immunity. Early studies using solubilized or sonicated SRBCs argued that the intact structure of SRBCs was important for optimal antibody responses. However, the reason for the requirement of intact SRBCs for the response to polyvalent protein antigen remained unknown. Here, we report that the immune response to SRBCs is driven by cytosolic recognition of SRBC RNA through the RIG-I-like receptor (RLR)-mitochondrial anti-viral signaling adaptor (MAVS) pathway...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29102975/fatal-delayed-haemolytic-transfusion-reaction-in-a-patient-without-previous-transfusions-but-with-an-obstetric-history-of-13-pregnancies
#19
Evgeni Chubar, Naiel Bisharat
Delayed haemolytic transfusion reaction is a rare, life-threatening complication of blood transfusion that has been typically described among patients with sickle cell disease (SCD) due to alloimmunisation induced by their exposure to red blood cell antigens through recurrent transfusions. We report the case of a patient who suffered from fatal delayed haemolytic transfusion reaction (DHTR) occurring 1 week after blood transfusion. Indirect antiglobulin testing confirmed the presence of anti-Kell antibodies that were absent in the pretransfusion sample...
November 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29100811/plasmodium-falciparum-export-protein-pfe60-influences-maurer-s-cleft-architecture-and-virulence-complex-composition
#20
Meng Zhang, Pierre Faou, Alexander G Maier, Melanie Rug
Plasmodium falciparum, the most lethal malaria parasite species for humans, vastly remodels the mature erythrocyte host cell upon invasion for its own survival. Maurer's clefts are membraneous structures established by the parasite in the cytoplasm of infected cells. These organelles are deemed essential for trafficking of virulence complex proteins. The display of the major virulence protein, P. falciparum erythrocyte membrane protein 1 on the surface of the infected red blood cell and the subsequent cytoadhesion of infected cells in the microvasculature of vital organs is the key mechanism that leads to the pathology associated with malaria infection...
November 1, 2017: International Journal for Parasitology
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