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https://www.readbyqxmd.com/read/28634161/oncolytic-adenovirus-expressing-bispecific-antibody-targets-t-cell-cytotoxicity-in-cancer-biopsies
#1
Joshua D Freedman, Joachim Hagel, Eleanor M Scott, Ioannis Psallidas, Avinash Gupta, Laura Spiers, Paul Miller, Nikolaos Kanellakis, Rebecca Ashfield, Kerry D Fisher, Margaret R Duffy, Leonard W Seymour
Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express a bispecific single-chain antibody, secreted from infected tumour cells into the microenvironment. This bispecific T-cell engager (BiTE) binds to EpCAM on target cells and cross-links them to CD3 on T cells, leading to clustering and activation of both CD4 and CD8 T cells. BiTE transcription can be controlled by the virus major late promoter, limiting expression to cancer cells that are permissive for virus replication...
June 20, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28629419/effect-of-beta-blockers-on-exacerbation-rate-and-lung-function-in-chronic-obstructive-pulmonary-disease-copd
#2
Sean Duffy, Robert Marron, Helen Voelker, Richard Albert, John Connett, William Bailey, Richard Casaburi, J Allen Cooper, Jeffrey L Curtis, Mark Dransfield, MeiLan K Han, Barry Make, Nathaniel Marchetti, Fernando Martinez, Stephen Lazarus, Dennis Niewoehner, Paul D Scanlon, Frank Sciurba, Steven Scharf, Robert M Reed, George Washko, Prescott Woodruff, Charlene McEvoy, Shawn Aaron, Don Sin, Gerard J Criner
BACKGROUND: Beta-blockers are commonly prescribed for patients with cardiovascular disease. Providers have been wary of treating chronic obstructive pulmonary disease (COPD) patients with beta-blockers due to concern for bronchospasm, but retrospective studies have shown that cardio-selective beta-blockers are safe in COPD and possibly beneficial. However, these benefits may reflect symptom improvements due to the cardiac effects of the medication. The purpose of this study is to evaluate associations between beta-blocker use and both exacerbation rates and longitudinal measures of lung function in two well-characterized COPD cohorts...
June 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28625374/change-the-management-of-patients-with-heart-failure-rationale-and-design-of-the-champ-hf-registry
#3
Adam D DeVore, Laine Thomas, Nancy M Albert, Javed Butler, Adrian F Hernandez, J Herbert Patterson, John A Spertus, Fredonia B Williams, Stuart J Turner, Wing W Chan, Carol I Duffy, Kevin McCague, Xiaojuan Mi, Gregg C Fonarow
Heart failure (HF) with reduced ejection fraction (HFrEF) is a common and costly condition that diminishes patients' health status and confers a poor prognosis. Despite the availability of multiple guideline-recommended pharmacologic and cardiac device therapies for patients with chronic HFrEF, outcomes remain suboptimal. Currently, there is limited insight into the rationale underlying clinical decisions by health care providers and patient factors that guide the use and intensity of outpatient HF treatments...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28621643/the-clinical-effectiveness-of-different-surveillance-strategies-to-prevent-colorectal-cancer-in-people-with-intermediate-grade-colorectal-adenomas-a-retrospective-cohort-analysis-and-psychological-and-economic-evaluations
#4
Wendy Atkin, Amy Brenner, Jessica Martin, Katherine Wooldrage, Urvi Shah, Fiona Lucas, Paul Greliak, Kevin Pack, Ines Kralj-Hans, Ann Thomson, Sajith Perera, Jill Wood, Anne Miles, Jane Wardle, Benjamin Kearns, Paul Tappenden, Jonathan Myles, Andrew Veitch, Stephen W Duffy
BACKGROUND: The UK guideline recommends 3-yearly surveillance for patients with intermediate-risk (IR) adenomas. No study has examined whether or not this group has heterogeneity in surveillance needs. OBJECTIVES: To examine the effect of surveillance on colorectal cancer (CRC) incidence; assess heterogeneity in risk; and identify the optimum frequency of surveillance, the psychological impact of surveillance, and the cost-effectiveness of alternative follow-up strategies...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28621602/resolution-of-nonurine-transudative-pleural-effusion-in-a-cat-after-removal-of-a-hydronephrotic-kidney
#5
Maura E Duffy, Andrew J Specht, Ahmira R Torres, May-Li Cuypers
CASE DESCRIPTION A 3-year-old spayed female Bengal cat was evaluated because of a history of bilateral pleural effusion and hydronephrosis of the right kidney. CLINICAL FINDINGS Cytologic analysis of a pleural fluid sample revealed characteristics of a pure transudate with a high percentage of lymphocytes. Results of fluid biochemical testing were not consistent with urine or chyle. Serum biochemical analysis and echocardiography yielded no evidence of hypoalbuminemia or high hydrostatic pressure secondary to cardiac disease...
July 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28615382/factors-influencing-the-gut-microbiota-inflammation-and-type-2-diabetes
#6
REVIEW
Li Wen, Andrew Duffy
The gut microbiota is a complex community of bacteria residing in the intestine. Animal models have demonstrated that several factors contribute to and can significantly alter the composition of the gut microbiota, including genetics; the mode of delivery at birth; the method of infant feeding; the use of medications, especially antibiotics; and the diet. There may exist a gut microbiota signature that promotes intestinal inflammation and subsequent systemic low-grade inflammation, which in turn promotes the development of type 2 diabetes...
June 14, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28614990/screening-organization-and-recall-rate-in-a-regional-breast-screening-programme
#7
Tina Beruchashwili, Rema Gvamichava, Stephen W Duffy
Objective To use results on recall rates from a regional non-population-based breast screening programme to inform practice in a planned national population-based programme. Methods We analysed data on rates of recall for further assessment in 27,327 mammographic screening episodes in 2015-2016 in the breast screening programme in the city of Tbilisi, Georgia. Screening was done by two-view digital mammography with double reading in women aged 40-70, and further assessment took place at the same clinic and during the same visit as the initial screening mammogram...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28614791/human-vaccination-against-plasmodium-vivax-duffy-binding-protein-induces-strain-transcending-antibodies
#8
Ruth O Payne, Sarah E Silk, Sean C Elias, Kathryn H Milne, Thomas A Rawlinson, David Llewellyn, A Rushdi Shakri, Jing Jin, Geneviève M Labbé, Nick J Edwards, Ian D Poulton, Rachel Roberts, Ryan Farid, Thomas Jørgensen, Daniel Gw Alanine, Simone C de Cassan, Matthew K Higgins, Thomas D Otto, James S McCarthy, Willem A de Jongh, Alfredo Nicosia, Sarah Moyle, Adrian Vs Hill, Eleanor Berrie, Chetan E Chitnis, Alison M Lawrie, Simon J Draper
BACKGROUND: Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with clinical immunity, but it is unknown whether these responses can be induced by human vaccination...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28604189/utility-of-single-energy-and-dual-energy-computed-tomography-in-clot-characterization-an-in-vitro-study
#9
Waleed Brinjikji, Gregory Michalak, Ramanathan Kadirvel, Daying Dai, Michael Gilvarry, Sharon Duffy, David F Kallmes, Cynthia McCollough, Shuai Leng
Background and purpose Because computed tomography (CT) is the most commonly used imaging modality for the evaluation of acute ischemic stroke patients, developing CT-based techniques for improving clot characterization could prove useful. The purpose of this in-vitro study was to determine which single-energy or dual-energy CT techniques provided optimum discrimination between red blood cell (RBC) and fibrin-rich clots. Materials and methods Seven clot types with varying fibrin and RBC densities were made (90% RBC, 99% RBC, 63% RBC, 36% RBC, 18% RBC and 0% RBC with high and low fibrin density) and their composition was verified histologically...
June 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28599431/the-expression-of-duffy-antigen-receptor-for-chemokines-by-epithelial-ovarian-cancer-decreases-growth-potential
#10
Qinyi Zhu, Lu Jiang, Xipeng Wang
Epithelial ovarian cancer (EOC) is one of the main causes of cancer-associated mortality in females with gynecological malignancies. Duffy antigen receptor for chemokines (DARC) has previously been reported to be involved in tumor growth and the inhibition of tumor metastasis. However, the association between DARC and EOC remains unknown. The aim of the present study was to investigate the expression of DARC in the SKOV3 human epithelial ovarian cancer cell line with the establishment of a subcutaneous model in nude mice...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28597547/controlled-growth-of-monocrystalline-organo-lead-halide-perovskite-and-its-application-in-photonic-devices
#11
Wenxin Mao, Jialu Zheng, Yupeng Zhang, Anthony S R Chesman, Qingdong Ou, Jamie Hicks, Feng Li, Ziyu Wang, Brenton Graystone, Toby Bell, Mathias Uller Rothmann, Noel Duffy, Yibing Cheng, Leone Spiccia, Qiaoliang Bao, Udo Bach
Organo-lead halide perovskites as a new class of exceptional optoelectronic materials has been found use in many applications. However, conventional methods for forming single crystals of OHPs afford limited control over the product morphology, rendering the assembly of defined microstructures difficult. We overcame this by synthesising for the first time (MA)[PbBr3]·DMF (1), and demonstrating its facile transformation into monocrystalline MAPbBr3 microplatelets, which exhibit excellent waveguiding porperty with an ultra-low propagation loss of 0...
June 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28596615/assessing-national-biodiversity-trends-for-rocky-and-coral-reefs-through-the-integration-of-citizen-science-and-scientific-monitoring-programs
#12
Rick D Stuart-Smith, Graham J Edgar, Neville S Barrett, Amanda E Bates, Susan C Baker, Nicholas J Bax, Mikel A Becerro, Just Berkhout, Julia L Blanchard, Daniel J Brock, Graeme F Clark, Antonia T Cooper, Tom R Davis, Paul B Day, J Emmett Duffy, Thomas H Holmes, Steffan A Howe, Alan Jordan, Stuart Kininmonth, Nathan A Knott, Jonathan S Lefcheck, Scott D Ling, Amanda Parr, Elisabeth Strain, Hugh Sweatman, Russell Thomson
Reporting progress against targets for international biodiversity agreements is hindered by a shortage of suitable biodiversity data. We describe a cost-effective system involving Reef Life Survey citizen scientists in the systematic collection of quantitative data covering multiple phyla that can underpin numerous marine biodiversity indicators at high spatial and temporal resolution. We then summarize the findings of a continental- and decadal-scale State of the Environment assessment for rocky and coral reefs based on indicators of ecosystem state relating to fishing, ocean warming, and invasive species and describing the distribution of threatened species...
February 1, 2017: Bioscience
https://www.readbyqxmd.com/read/28596308/mismatch-repair-deficiency-predicts-response-of-solid-tumors-to-pd-1-blockade
#13
Dung T Le, Jennifer N Durham, Kellie N Smith, Hao Wang, Bjarne R Bartlett, Laveet K Aulakh, Steve Lu, Holly Kemberling, Cara Wilt, Brandon S Luber, Fay Wong, Nilofer S Azad, Agnieszka A Rucki, Dan Laheru, Ross Donehower, Atif Zaheer, George A Fisher, Todd S Crocenzi, James J Lee, Tim F Greten, Austin G Duffy, Kristen K Ciombor, Aleksandra D Eyring, Bao H Lam, Andrew Joe, S Peter Kang, Matthias Holdhoff, Ludmila Danilova, Leslie Cope, Christian Meyer, Shibin Zhou, Richard M Goldberg, Deborah K Armstrong, Katherine M Bever, Amanda N Fader, Janis Taube, Franck Housseau, David Spetzler, Nianqing Xiao, Drew M Pardoll, Nickolas Papadopoulos, Kenneth W Kinzler, James R Eshleman, Bert Vogelstein, Robert A Anders, Luis A Diaz
The genomes of cancers deficient in mismatch repair (MMR) contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers with MMR deficiency were sensitive to immune checkpoint blockade with anti-PD-1 antibodies. We have expanded this study to now evaluate efficacy of PD-1 blockade in patients with advanced MMR-deficient cancers across 12 different tumor types. Objective radiographic responses were observed in 53% of patients and complete responses were achieved in 21% of patients...
June 8, 2017: Science
https://www.readbyqxmd.com/read/28591513/unravelling-the-molecular-basis-of-high-affinity-nanobodies-against-hiv-p24-in-vitro-functional-structural-and-in-silico-insights
#14
Eleanor Ruth Gray, Jennifer Clare Brookes, Christophe Caillat, Valérian Turbé, Benjamin Lj Webb, Luke A Granger, Benjamin Saul Miller, Laura E McCoy, Mohamed El Khattabi, C Theo Verrips, Robin A Weiss, Dorothy M Duffy, Winfried Weissenhorn, Rachel A McKendry
Preventing the spread of infectious diseases remains an urgent priority worldwide and this is driving the development of advanced nanotechnology to diagnose infections at the point of care. Herein we report the creation of a library of novel nanobody capture ligands to detect p24, one of the earliest markers of HIV infection. We demonstrate that these nanobodies, one tenth the size of conventional antibodies, exhibit high sensitivity and broad specificity to global HIV-1 subtypes. Biophysical characterisation indicates strong 690pM binding constants and fast kinetic on-rates, one to two orders of magnitude better than monoclonal antibody comparators...
June 7, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28587995/duffy-blood-group-system-new-genotyping-method-and-distribution-in-a-brazilian-extra-amazonian-population
#15
Marina Lobato Martins, Adão Rogerio da Silva, Hadassa Campos Santos, Michelle Teodoro Alves, Luciana Cayres Schmidt, Stela Brener Vertchenko, Luci Maria SantAna Dusse, Maria Clara Fernandes da Silva Malta
Duffy blood group system is of interest in several fields of science including transfusion medicine, immunology and malariology. Although some methods have been developed for Duffy polymorphism genotyping, not all of them have been sufficiently described and validated, and all present limitations. At the same time, the frequency of Duffy alleles and antigens in some densely populated regions of the world are still missing. In this study we present new tests for genotyping the major alleles of the Duffy blood system and describe Duffy alleles and antigens in blood donors and transfusion-dependent patients in Minas Gerais, Brazil...
June 3, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28580947/pyrin-only-protein-2-limits-inflammation-but-improves-protection-against-bacteria
#16
Sivakumar Periasamy, Kristen A Porter, Maninjay K Atianand, Hongnga T Le, Sarah Earley, Ellen B Duffy, Matthew C Haller, Heather Chin, Jonathan A Harton
Pyrin domain-only proteins (POPs) are recently evolved, primate-specific proteins demonstrated in vitro as negative regulators of inflammatory responses. However, their in vivo function is not understood. Of the four known POPs, only POP2 is reported to regulate NF-κB-dependent transcription and multiple inflammasomes. Here we use a transgenic mouse-expressing POP2 controlled by its endogenous human promotor to study the immunological functions of POP2. Despite having significantly reduced inflammatory cytokine responses to LPS and bacterial infection, POP2 transgenic mice are more resistant to bacterial infection than wild-type mice...
June 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28579822/quantitative-sensory-testing-measures-individual-pain-responses-in-emergency-department-patients
#17
Kevin J Duffy, Katharyn L Flickinger, Jeffrey T Kristan, Melissa J Repine, Alexandro Gianforcaro, Rebecca B Hasley, Saad Feroz, Jessica M Rupp, Jumana Al-Baghli, Maria L Pacella, Brian P Suffoletto, Clifton W Callaway
BACKGROUND: Refining and individualizing treatment of acute pain in the emergency department (ED) is a high priority, given that painful complaints are the most common reasons for ED visits. Few tools exist to objectively measure pain perception in the ED setting. We speculated that variation in perception of fixed painful stimuli would explain individual variation in reported pain and response to treatment among ED patients. MATERIALS AND METHODS: In three studies, we 1) describe performance characteristics of brief quantitative sensory testing (QST) in 50 healthy volunteers, 2) test effects of 10 mg oxycodone versus placebo on QST measures in 18 healthy volunteers, and 3) measure interindividual differences in nociception and treatment responses in 198 ED patients with a painful complaint during ED treatment...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28569811/linking-the-influence-and-dependence-of-people-on-biodiversity-across-scales
#18
Forest Isbell, Andrew Gonzalez, Michel Loreau, Jane Cowles, Sandra Díaz, Andy Hector, Georgina M Mace, David A Wardle, Mary I O'Connor, J Emmett Duffy, Lindsay A Turnbull, Patrick L Thompson, Anne Larigauderie
Biodiversity enhances many of nature's benefits to people, including the regulation of climate and the production of wood in forests, livestock forage in grasslands and fish in aquatic ecosystems. Yet people are now driving the sixth mass extinction event in Earth's history. Human dependence and influence on biodiversity have mainly been studied separately and at contrasting scales of space and time, but new multiscale knowledge is beginning to link these relationships. Biodiversity loss substantially diminishes several ecosystem services by altering ecosystem functioning and stability, especially at the large temporal and spatial scales that are most relevant for policy and conservation...
May 31, 2017: Nature
https://www.readbyqxmd.com/read/28569193/health-care-utilization-in-patients-with-gout-a-prospective-multicenter-cohort-study
#19
Jasvinder A Singh, Aseem Bharat, Dinesh Khanna, Cleopatra Aquino-Beaton, Jay E Persselin, Erin Duffy, David Elashoff, Puja P Khanna
BACKGROUND: All published studies of health care utilization in gout have been cross-sectional to date, and most used a patient-reported diagnosis of gout. Our objective was to assess health care utilization and its predictors in patients with physician-confirmed gout in a prospective cohort study. METHODS: In a multi-center prospective cohort study of U.S. veterans with rheumatologist-confirmed gout (N = 186; two centers), we assessed patient self-reported overall and gout-specific health care utilization with the Gout Assessment Questionnaire (GAQ) every 3-months for a 9-month period...
May 31, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28564693/vesicular-rash-in-a-neutropenic-infant
#20
Courtney Gwinn, Jason E Hawkes, Keith L Duffy
No abstract text is available yet for this article.
May 31, 2017: JAMA Dermatology
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