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https://www.readbyqxmd.com/read/29457539/vocalization-development-in-common-marmosets-for-neurodegenerative-translational-modeling
#1
Corinne A Jones, Mary K Duffy, Sarah A Hoffman, Nancy J Schultz-Darken, Katarina M Braun, Michelle R Ciucci, Marina E Emborg
Objectives In order to facilitate the study of vocalizations in emerging genetic common marmoset models of neurodegenerative disorders, we aimed to analyze call-type changes across age in a translational research environment. We hypothesized that acoustic parameters of vocalizations would change with age, reflecting growth of the vocal apparatus and a maturation of control needed to make adult-like calls. Methods Nineteen developing common marmosets were longitudinally video- and audio-recorded between the ages of 1-149 days in a naturalistic setting without any vocalization elicitation protocol...
February 19, 2018: Neurological Research
https://www.readbyqxmd.com/read/29451323/-18f-av-1451-tau-pet-and-primary-progressive-aphasia
#2
Keith A Josephs, Peter R Martin, Hugo Botha, Christopher G Schwarz, Joseph R Duffy, Heather M Clark, Mary M Machulda, Jonathan Graff-Radford, Stephen D Weigand, Matthew L Senjem, Rene L Utianski, Daniel A Drubach, Bradley F Boeve, David T Jones, David S Knopman, Ronald C Petersen, Clifford R Jack, Val J Lowe, Jennifer L Whitwell
OBJECTIVES: To assess [ 18 F]AV-1451 tau-PET uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic and agrammatic), examine regional uptake patterns of [ 18 F]AV-1451 independent of clinical diagnosis, and compare the diagnostic utility of [ 18 F]AV-1451, [ 18 F]-fluorodeoxygluclose (FDG)-PET and MRI to differentiate the PPA variants. METHODS: We performed statistical parametric mapping of [ 18 F]AV-1451 across 40 PPA patients (logopenic-PPA=14, semantic-PPA=13 and agrammatic-PPA=13) compared to 80 cognitively normal, PiB-negative controls, age and gender matched 2:1...
February 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29441647/methods-for-addressing-innocent-bystanders-when-evaluating-safety-of-concomitant-vaccines
#3
Shirley V Wang, Abdurrahman Abdurrob, Julia Spoendlin, Edwin Lewis, Sophia R Newcomer, Bruce Fireman, Matthew F Daley, Jason M Glanz, Jonathan Duffy, Eric S Weintraub, Martin Kulldorff
PURPOSE: The need to develop methods for studying the safety of childhood immunization schedules has been recognized by the Institute of Medicine and Department of Health and Human Services. The recommended childhood immunization schedule includes multiple vaccines in a visit. A key concern is safety of concomitant (same day) versus separate day vaccination. This paper addresses a methodological challenge for observational studies using a self-controlled design to investigate the safety of concomitant vaccination...
February 13, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29439382/the-impact-of-occupational-splash-sharps-and-needlestick-injuries-ssnis-on-the-quality-of-life-of-healthcare-workers-in-a-kenyan-university-hospital
#4
George Ongete, Francis John Raymond Duffy
BACKGROUND: Infection as a consequence of splash sharps and needlestick injuries (SSNIs) is a hazard faced by healthcare workers. Little is known about the impact this has on quality of life particularly in countries where the risk of infection is high. OBJECTIVE: This study aims to describe the impact SSNIs have on the quality of life of healthcare workers in Kenya, where blood borne illness prevalence is high. METHODS: A hospital-wide survey of a facility in Nairobi was conducted...
2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29435786/standards-of-evidence-for-conducting-and-reporting-economic-evaluations-in-prevention-science
#5
D Max Crowley, Kenneth A Dodge, W Steven Barnett, Phaedra Corso, Sarah Duffy, Phillip Graham, Mark Greenberg, Ron Haskins, Laura Hill, Damon E Jones, Lynn A Karoly, Margaret R Kuklinski, Robert Plotnick
Over a decade ago, the Society for Prevention Research endorsed the first standards of evidence for research in preventive interventions. The growing recognition of the need to use limited resources to make sound investments in prevention led the Board of Directors to charge a new task force to set standards for research in analysis of the economic impact of preventive interventions. This article reports the findings of this group's deliberations, proposes standards for economic analyses, and identifies opportunities for future prevention science...
February 12, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29435209/the-relative-contribution-of-diurnal-and-nocturnal-pollinators-to-plant-female-fitness-in-a-specialized-nursery-pollination-system
#6
Giovanni Scopece, Lucia Campese, Karl J Duffy, Salvatore Cozzolino
Plants involved in specialized pollinator interactions, such as nursery pollination, may experience trade-offs in their female fitness, as the larvae of their pollinators may also consume seeds produced by the flowers they pollinate. These interactions could potentially shift between mutualism and parasitism, depending on the presence and abundance of both the nursery pollinator and of other pollinators. We investigated the fitness trade-off in a Mediterranean plant (Silene latifolia), which has a specialist nocturnal nursery pollinator moth (Hadena bicruris) and is also visited by several diurnal pollinators...
February 2018: AoB Plants
https://www.readbyqxmd.com/read/29434602/identification-of-a-novel-cd8-t-cell-epitope-derived-from-plasmodium-berghei-protective-liver-stage-antigen
#7
Alexander Pichugin, Stasya Zarling, Leah Perazzo, Patrick Emmet Duffy, Hidde Lolke Ploegh, Urszula Krzych
We recently identified novel Plasmodium berghei (Pb) liver stage (LS) genes that as DNA vaccines significantly reduce Pb LS parasite burden (LPB) in C57Bl/6 (B6) mice through a mechanism mediated, in part, by CD8 T cells. In this study, we sought to determine fine antigen (Ag) specificities of CD8 T cells that target LS malaria parasites. Guided by algorithms for predicting MHC class I-restricted epitopes, we ranked sequences of 32 Pb LS Ags and selected ~400 peptides restricted by mouse H-2Kb and H-2Db alleles for analysis in the high-throughput method of caged MHC class I-tetramer technology...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29425093/in-memoriam-james-m-melius-md-drph
#8
Philip J Landrigan, Knut Ringen, Richard M Duffy
No abstract text is available yet for this article.
February 8, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29422513/genetic-relatedness-reveals-total-population-size-of-white-sharks-in-eastern-australia-and-new-zealand
#9
R M Hillary, M V Bravington, T A Patterson, P Grewe, R Bradford, P Feutry, R Gunasekera, V Peddemors, J Werry, M P Francis, C A J Duffy, B D Bruce
Conservation concerns exist for many sharks but robust estimates of abundance are often lacking. Improving population status is a performance measure for species under conservation or recovery plans, yet the lack of data permitting estimation of population size means the efficacy of management actions can be difficult to assess, and achieving the goal of removing species from conservation listing challenging. For potentially dangerous species, like the white shark, balancing conservation and public safety demands is politically and socially complex, often leading to vigorous debate about their population status...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29422046/easy-and-fast-method-for-expression-and-native-extraction-of-plasmodium-vivax-duffy-binding-protein-fragments
#10
Darwin Andrés Moreno-Pérez, Luis Alfredo Baquero, Maritza Bermúdez, Laura Alejandra Gómez-Muñoz, Yahson Varela, Manuel Alfonso Patarroyo
BACKGROUND: The Plasmodium vivax Duffy binding protein (PvDBP) has been the most studied ligand binding human reticulocytes to date. This molecule has a cysteine-rich domain in region II (RII) which has been used as control for evaluating the target cell binding activity of several parasite molecules. However, obtaining rPvDBP-RII in a soluble form using the Escherichia coli expression system usually requires laborious and time-consuming steps for recovering the molecule's structure and function, considering it is extracted from inclusion bodies...
February 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29421483/effect-of-suckler-cow-vaccination-against-glycoprotein-e-ge-negative-bovine-herpesvirus-type-1-bohv-1-on-passive-immunity-and-physiological-response-to-subsequent-bovine-respiratory-disease-vaccination-of-their-progeny
#11
Bernadette Earley, Katie Tiernan, Catherine Duffy, Amanda Dunn, Sinead Waters, Steven Morrison, Mark McGee
The study objectives were: 1) to characterise the development of immunocompetence in beef suckler calves from birth to three months of age, and 2) to trace glycoprotein E (gE)-negative bovine herpesvirus type 1 (BoHV-1) antibodies from dam to calf and subsequent vaccination against pneumonia. Thirty multiparous beef suckler, spring-calving cows, consisting of two genotypes were involved; Limousin×Friesian (LF) and Charolais×Limousin (CL). Cows were immunised against the inactivated antigen strain of BoHV-1 (gE- (IBR marker vaccine) at day -84 and received a booster at day -56 relative to the expected calving date (d 0)...
January 10, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29420756/potent-plasmodium-falciparum-gametocytocidal-compounds-identified-by-exploring-the-kinase-inhibitor-chemical-space-for-dual-active-antimalarials
#12
Mariëtte E van der Watt, Janette Reader, Alisje Churchyard, Sindisiwe H Nondaba, Sonja B Lauterbach, Jandeli Niemand, Sijuade Abayomi, Riëtte A van Biljon, Jessica I Connacher, Roelof D J van Wyk, Claire Le Manach, Tanya Paquet, Diego González Cabrera, Christel Brunschwig, Anjo Theron, Sonia Lozano-Arias, Janneth F I Rodrigues, Esperanza Herreros, Didier Leroy, James Duffy, Leslie J Street, Kelly Chibale, Dalu Mancama, Theresa L Coetzer, Lyn-Marie Birkholtz
Objectives: Novel chemical tools to eliminate malaria should ideally target both the asexual parasites and transmissible gametocytes. Several imidazopyridazines (IMPs) and 2-aminopyridines (2-APs) have been described as potent antimalarial candidates targeting lipid kinases. However, these have not been extensively explored for stage-specific inhibition of gametocytes in Plasmodium falciparum parasites. Here we provide an in-depth evaluation of the gametocytocidal activity of compounds from these chemotypes and identify novel starting points for dual-acting antimalarials...
February 6, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29419941/toward-the-full-spectrum-of-genes-for-human-skin-colour
#13
Richard A Sturm, David L Duffy
Humans across the globe shows a remarkable diversity in colouration of skin, hair and eyes (Jablonski & Chaplin, 2017) reflecting adaption of pigmentation genes within populations to their environment (Sturm & Duffy, 2012), as well as other evolutionary forces. Skin colour is highly correlated with incident levels of solar UV, and this has led to hypotheses that the need for vitamin D synthesis and protection from photolysis of folate are major balancing selective pressures modulating melanogenesis in the epidermis necessary for both healthy bones at high Northern latitudes experiencing low solar irradiance, but also shielding the skin from the high equatorial sun exposure...
February 8, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29418003/in-vitro-evaluation-of-chitosan-copper-chelate-gels-as-a-multimicronutrient-feed-additive-for-cattle
#14
Ciara Duffy, E Dolores O' Riordan, Michael O' Sullivan, Jean-Christophe Jacquier
BACKGROUND: Effective micronutrient supplementation strategies are critical to ensure optimal health and productivity in livestock. The objective of this study was to develop a copper and vitamin (multimicronutrient) delivery system based on chitosan gel beads, and test its suitability, in vitro, for use as a cattle feed additive. RESULTS: Chitosan was chelated with copper sulphate to produce millimetre-scale gel matrices (~2mm). The copper content was significantly increased (from 61 to 95mg...
February 8, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29416729/multicomponent-analysis-of-the-tumour-microenvironment-reveals-low-cd8-t-cell-number-low-stromal-caveolin-1-and-high-tenascin-c-and-their-combination-as-significant-prognostic-markers-in-non-small-cell-lung-cancer
#15
David Onion, Mark Isherwood, Naveen Shridhar, Mikalena Xenophontos, Madeleine L Craze, Laura J Day, María A García-Márquez, Robert G Pineda, Alexander M Reece-Smith, John H Saunders, John P Duffy, Richard H Argent, Anna M Grabowska
The complex interplay of the tumour microenvironment (TME) and its role in disease progression and response to therapy is poorly understood. The majority of studies to date focus on individual components or molecules within the TME and so lack the power correlative analysis. Here we have performed a multi-parameter analysis of the TME in 62 resectable non-small cell lung cancer (NSCLC) specimens detailing number and location of immune infiltrate, assessing markers of cancer-associated fibroblasts, caveolin-1 and tenascin-C, and correlating with clinicopathological details, as well as markers of disease progression such as epithelial-to-mesenchymal transition (EMT)...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414811/functional-implications-of-cross-linked-actin-networks-in-trabecular-meshwork-cells
#16
Laura Duffy, Steven O'Reilly
BACKGROUND/AIMS: The Trabecular meshwork (TM) is the tissue responsible for outflow resistance and therefore intraocular pressure. TM cells contain a contractile apparatus that is composed of actin stress fibres which run parallel to the axis of the cell and are responsible for facilitating contraction. Cross-Linked Actin Networks (CLANs) are polygonal arrangements of actin that form a geodesic network found predominantly in TM cells both in situ and in vitro. The aim of this work is to determine the functional significance of CLANs in TM cells and to assess the effect of mechanical stretch stimulation on the induction (or not) of CLANs...
February 1, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29412982/circadian-rhythm-sleep-wake-disorders-in-older-adults
#17
REVIEW
Jee Hyun Kim, Jeanne F Duffy
The timing, duration, and consolidation of sleep result from the interaction of the circadian timing system with a sleep-wake homeostatic process. When aligned and functioning optimally, this allows wakefulness throughout the day and a long consolidated sleep episode at night. Mismatch between the desired timing of sleep and the ability to fall and remain asleep is a hallmark of the circadian rhythm sleep-wake disorders. This article discusses changes in circadian regulation of sleep with aging; how age influences the prevalence, diagnosis, and treatment of circadian rhythm sleep-wake disorders; and how neurologic diseases in older patients affect circadian rhythms and sleep...
March 2018: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29411909/gene-expression-profiles-of-the-meniscus-avascular-phenotype-a-guide-for-meniscus-tissue-engineering
#18
Shawn P Grogan, Stuart F Duffy, Chantal Pauli, Martin K Lotz, Darryl D D'Lima
Avascular (Avas) meniscus regeneration remains a challenge, which is partly a consequence of our limited knowledge of the cells that maintain this tissue region. In this study, we utilized microarrays to characterize gene expression profiles of intact human Avas meniscus tissue and of cells following culture expansion. Using these data, we examined various 3D culture conditions to redifferentiate Avas cells toward the tissue phenotype. RNA was isolated from either the tissue directly or following cell isolation and 2 weeks in monolayer culture...
February 7, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29410432/proliferation-dynamics-of-acute-myeloid-leukaemia-and-haematopoietic-progenitors-competing-for-bone-marrow-space
#19
O Akinduro, T S Weber, H Ang, M L R Haltalli, N Ruivo, D Duarte, N M Rashidi, E D Hawkins, K R Duffy, C Lo Celso
Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood. Combining cell number measurements with a short-timescale dual pulse labelling method, we simultaneously determine the proliferation dynamics of primitive haematopoietic compartments and acute myeloid leukaemia (AML). We observe an unchanging proportion of AML cells entering S phase per hour throughout disease progression, with substantial BM egress at high levels of infiltration...
February 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29407899/the-relationship-between-external-auditory-canal-temperature-and-onset-of-estrus-and-ovulation-in-beef-heifers
#20
Federico Randi, Michael McDonald, Pat Duffy, Alan K Kelly, Patrick Lonergan
The aim of this study was to evaluate the relationship of body temperature fluctuations, as measured by external auditory canal temperature, to the onset of estrus and ovulation. Beef heifers (n = 44, mean age 23.5 ± 0.4 months, mean weight 603.3 ± 5.7 kg) were fitted with a Boviminder® ear tag 2 weeks before the start of the estrous synchronization protocol to allow acclimatization. The device recorded the temperature, accurate to 0.01° Fahrenheit, every 10 min and transmitted the data via a base station over the internet where it could be accessed remotely...
January 9, 2018: Theriogenology
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