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https://www.readbyqxmd.com/read/29237481/retraction-note-transgenic-mice-overexpressing-the-als-linked-protein-matrin-3-develop-a-profound-muscle-phenotype
#1
Christina Moloney, Sruti Rayaprolu, John Howard, Susan Fromholt, Hilda Brown, Matt Collins, Mariela Cabrera, Colin Duffy, Zoe Siemienski, Dave Miller, Maurice S Swanson, Lucia Notterpek, David R Borchelt, Jada Lewis
The authors are retracting this article. The article describes mice expressing wild-type human MATR3. However, since publication the authors have become aware that all of the lines of mice described express human MATR3 containing the F115C mutation. Transgenic mice expressing wild-type and mutant Matrin were created simultaneously in their laboratory and, at a crucial stage of generating the DNA for embryo injection, as confirmed by an investigation by the University of Florida, the DNA preparations were accidentally mislabelled...
December 13, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29236492/pimentelamines-a-c-indole-alkaloids-isolated-from-the-leaves-of-the-australian-tree-flindersia-pimenteliana
#2
Luke P Robertson, Sandra Duffy, Yun Wang, Dongdong Wang, Vicky M Avery, Anthony R Carroll
Three members of a new class of ascorbic acid-adduct indole alkaloids (1-3), a new prenylated indole alkaloid (4), and five known compounds (5-9) were isolated from the leaves of Flindersia pimenteliana. The structures of 1-4 were elucidated on the basis of their (+)-HRESIMS and 2D NMR spectroscopic data. Antiplasmodial activity was also reported for the natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum with IC50 values ranging from 0.19 to 3.6 μM.
December 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29228180/longitudinal-structural-and-molecular-neuroimaging-in-agrammatic-primary-progressive-aphasia
#3
Katerina A Tetzloff, Joseph R Duffy, Heather M Clark, Edythe A Strand, Mary M Machulda, Christopher G Schwarz, Matthew L Senjem, Robert I Reid, Anthony J Spychalla, Nirubol Tosakulwong, Val J Lowe, Clifford R Jack, Keith A Josephs, Jennifer L Whitwell
The agrammatic variant of primary progressive aphasia affects normal grammatical language production, often occurs with apraxia of speech, and is associated with left frontal abnormalities on cross-sectional neuroimaging studies. We aimed to perform a detailed assessment of longitudinal change on structural and molecular neuroimaging to provide a complete picture of neurodegeneration in these patients, and to determine how patterns of progression compare to patients with isolated apraxia of speech (primary progressive apraxia of speech)...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29225503/advection-and-taylor-aris-dispersion-in-rivulet-flow
#4
F H H Al Mukahal, B R Duffy, S K Wilson
Motivated by the need for a better understanding of the transport of solutes in microfluidic flows with free surfaces, the advection and dispersion of a passive solute in steady unidirectional flow of a thin uniform rivulet on an inclined planar substrate driven by gravity and/or a uniform longitudinal surface shear stress are analysed. Firstly, we describe the short-time advection of both an initially semi-infinite and an initially finite slug of solute of uniform concentration. Secondly, we describe the long-time Taylor-Aris dispersion of an initially finite slug of solute...
November 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29222583/correction-to-pioglitazone-reduces-cold-induced-brown-fat-glucose-uptake-despite-induction-of-browning-in-cultured-human-adipocytes-a-randomised-controlled-trial-in-humans
#5
Rebecca K C Loh, Melissa F Formosa, Nina Eikelis, David A Bertovic, Mitchell J Anderson, Shane A Barwood, Shane Nanayakkara, Neale D Cohen, Andre La Gerche, Anne T Reutens, Kenneth S Yap, Thomas W Barber, Gavin W Lambert, Martin H Cherk, Stephen J Duffy, Bronwyn A Kingwell, Andrew L Carey
The baseline insulin data given in Table 1 for the placebo group were incorrectly reported as 51 ± 10 pmol/l instead of 48 ± 10 pmol/l. This mistake also impacts on data reported in Table 4.
December 8, 2017: Diabetologia
https://www.readbyqxmd.com/read/29219448/improving-the-functional-control-of-aged-ferroelectrics-using-insights-from-atomistic-modeling
#6
J B J Chapman, R E Cohen, A V Kimmel, D M Duffy
We provide a fundamental insight into the microscopic mechanisms of the aging processes. Using large-scale molecular dynamics simulations of the prototypical ferroelectric material PbTiO_{3}, we demonstrate that the experimentally observed aging phenomena can be reproduced from intrinsic interactions of defect dipoles related to dopant-vacancy associates, even in the absence of extrinsic effects. We show that variation of the dopant concentration modifies the material's hysteretic response. We identify a universal method to reduce loss and tune the electromechanical properties of inexpensive ceramics for efficient technologies...
October 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29217556/coherent-nanoparticles-in-calcite
#7
Dorothy M Duffy
No abstract text is available yet for this article.
December 8, 2017: Science
https://www.readbyqxmd.com/read/29215826/when-is-the-need-for-speed
#8
Jeffrey M Goodloe, Curtis L Knoles, Duffy McAnallen, Matthew L Cox, David S Howerton
No abstract text is available yet for this article.
February 2017: JEMS: a Journal of Emergency Medical Services
https://www.readbyqxmd.com/read/29214056/strength-in-numbers-an-international-consensus-conference-to-develop-a-novel-approach-to-care-delivery-for-young-adults-with-type-1-diabetes-the-d1-now-study
#9
M C O'Hara, L Hynes, M O'Donnell, C Keighron, G Allen, A Caulfield, C Duffy, M Long, M Mallon, M Mullins, G Tonra, M Byrne, S F Dinneen
Plain English summary: Many young adults with type 1 diabetes struggle with the day-to-day management of their condition. They often find it difficult to find the time to attend their clinic appointments and to meet with their diabetes healthcare team. Young adults living with type 1 diabetes are not routinely involved in research that may help improve health services other than being invited to take part in studies as research participants. A 3-day international conference was held in Galway in June 2016 called "Strength In Numbers: Teaming up to improve the health of young adults with type 1 diabetes"...
2017: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29212726/rapid-evolution-rescues-hosts-from-competition-and-disease-but-despite-a-dilution-effect-increases-the-density-of-infected-hosts
#10
Alexander T Strauss, Jessica L Hite, Marta S Shocket, Carla E Cáceres, Meghan A Duffy, Spencer R Hall
Virulent parasites can depress the densities of their hosts. Taxa that reduce disease via dilution effects might alleviate this burden. However, 'diluter' taxa can also depress host densities through competition for shared resources. The combination of disease and interspecific competition could even drive hosts extinct. Then again, genetically variable host populations can evolve in response to both competitors and parasites. Can rapid evolution rescue host density from the harm caused by these ecological enemies? How might such evolution influence dilution effects or the size of epidemics? In a mesocosm experiment with planktonic hosts, we illustrate the joint harm of competition and disease: hosts with constrained evolutionary ability (limited phenotypic variation) suffered greatly from both...
December 6, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29208441/european-position-statement-on-lung-cancer-screening
#11
REVIEW
Matthijs Oudkerk, Anand Devaraj, Rozemarijn Vliegenthart, Thomas Henzler, Helmut Prosch, Claus P Heussel, Gorka Bastarrika, Nicola Sverzellati, Mario Mascalchi, Stefan Delorme, David R Baldwin, Matthew E Callister, Nikolaus Becker, Marjolein A Heuvelmans, Witold Rzyman, Maurizio V Infante, Ugo Pastorino, Jesper H Pedersen, Eugenio Paci, Stephen W Duffy, Harry de Koning, John K Field
Lung cancer screening with low-dose CT can save lives. This European Union (EU) position statement presents the available evidence and the major issues that need to be addressed to ensure the successful implementation of low-dose CT lung cancer screening in Europe. This statement identified specific actions required by the European lung cancer screening community to adopt before the implementation of low-dose CT lung cancer screening. This position statement recommends the following actions: a risk stratification approach should be used for future lung cancer low-dose CT programmes; that individuals who enter screening programmes should be provided with information on the benefits and harms of screening, and smoking cessation should be offered to all current smokers; that management of detected solid nodules should use semi-automatically measured volume and volume-doubling time; that national quality assurance boards should be set up to oversee technical standards; that a lung nodule management pathway should be established and incorporated into clinical practice with a tailored screening approach; that non-calcified baseline lung nodules greater than 300 mm3, and new lung nodules greater than 200 mm3, should be managed in multidisciplinary teams according to this EU position statement recommendations to ensure that patients receive the most appropriate treatment; and planning for implementation of low-dose CT screening should start throughout Europe as soon as possible...
December 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29204812/tumor-screening-in-beckwith-wiedemann-syndrome-parental-perspectives
#12
Kelly A Duffy, Katheryn L Grand, Kristin Zelley, Jennifer M Kalish
Children with Beckwith-Wiedemann Syndrome (BWS) and Isolated Hemihypertrophy (IHH) are at an increased risk for developing tumors. Tumor screening in this population is currently being reassessed by several groups and the effect on patients and patient-families has been argued both as a reason to screen and not to screen. Parental perspectives on this topic have never been systematically addressed for the BWS population. Here, we conducted a parent-based survey to evaluate knowledge and attitudes toward tumor screening in patients affected by BWS/IHH...
December 4, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29204062/hepatitis-b-virus-outreach-to-immigrant-population-in-greater-boston-area-key-to-improving-hepatitis-b-knowledge
#13
Raissa Djoufack, Scarlett Se Yun Cheon, Aisha Mohamed, Fatou Faye, Korka Diouf, Richard Colvin, James Morrill, Ann-Marie Duffy-Keane, Ponni Perumalswami, Gonzague Jourdain, Dahlene Fusco
AIM: To characterize the understanding of hepatitis B virus (HBV) and determine if outreach improves HBV understanding among Greater Boston Area immigrants. METHODS: Six outreach sessions were held in various community venues in the Greater Boston Area. Verbal consent was obtained from participants prior to starting each session. Each session included a pre-session questionnaire, followed by a teaching session, and then a post-session questionnaire. In person interpreters were present for translation during the teaching session and assistance for questionnaire completion when needed...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29200047/analysis-of-health-behavior-theories-for-clustering-of-health-behaviors
#14
Seung Hee Choi, Sonia A Duffy
OBJECTIVES: The objective of this article was to review the utility of established behavior theories, including the Health Belief Model, Theory of Reasoned Action, Theory of Planned Behavior, Transtheoretical Model, and Health Promotion Model, for addressing multiple health behaviors among people who smoke. It is critical to design future interventions for multiple health behavior changes tailored to individuals who currently smoke, yet it has not been addressed. METHODS: Five health behavior theories/models were analyzed and critically evaluated...
October 2017: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/29198986/australian-trends-in-procedural-characteristics-and-outcomes-in-patients-undergoing-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction
#15
Sinjini Biswas, Stephen J Duffy, Jeffrey Lefkovits, Nick Andrianopoulos, Angela Brennan, Antony Walton, William Chan, Samer Noaman, James A Shaw, Luke Dawson, Andrew Ajani, David J Clark, Melanie Freeman, Chin Hiew, Ernesto Oqueli, Christopher M Reid, Dion Stub
Over the last decade, systems of care for ST-elevation myocardial infarction (STEMI) have evolved to try to improve outcomes and timely access to percutaneous coronary intervention (PCI). There have also been advances in PCI techniques and adjunctive pharmacotherapies. In this study, we sought to determine temporal changes in practices and clinical outcomes of PCI in patients with STEMI. We prospectively collected data on 8,412 consecutive patients undergoing PCI for STEMI between 2005 and 2016 in the multicenter Melbourne Interventional Group registry...
October 31, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29198366/the-effectiveness-of-self-compassion-and-self-esteem-writing-tasks-in-reducing-body-image-concerns
#16
Veya Seekis, Graham L Bradley, Amanda Duffy
This study investigated whether single-session self-compassion and self-esteem writing tasks ameliorate the body image concerns evoked by a negative body image induction. Ninety-six female university students aged 17-25 years (Mage=19.45, SD=1.84) were randomly assigned to one of three writing treatment groups: self-compassion, self-esteem, or control. After reading a negative body image scenario, participants completed scales measuring state body appreciation, body satisfaction, and appearance anxiety. They then undertook the assigned writing task, and completed the three measures again, both immediately post-treatment and at 2-week follow-up...
December 2017: Body Image
https://www.readbyqxmd.com/read/29194667/evaluation-of-the-impact-of-banking-umbilical-cord-blood-units-with-high-cell-dose-for-ethnically-diverse-patients
#17
Gretta Stritesky, Kimberly Wadsworth, Merry Duffy, Kelly Buck, Jason Dehn
BACKGROUND: Umbilical cord blood units provide an important stem cell source for transplantation, particularly for patients of ethnic diversity who may not have suitably matched available, adult-unrelated donors. However, with the cost of cord blood unit acquisition from public banks significantly higher than that for adult-unrelated donors, attention is focused on decreasing cost yet still providing cord blood units to patients in need. Historical practices of banking units with low total nucleated cell counts, including units with approximately 90 × 107 total nucleated cells, indicates that most banked cord blood units have much lower total nucleated cell counts than are required for transplant...
December 1, 2017: Transfusion
https://www.readbyqxmd.com/read/29192106/dart-a-new-look-at-the-2-week-wait-suspected-cancer-referral-process
#18
Rob Eastham, Sean Duffy, Catherine Foster, Andrew Beaumont
No abstract text is available yet for this article.
December 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29190506/mammographic-density-and-breast-cancer-risk-in-breast-screening-assessment-cases-and-women-with-a-family-history-of-breast-cancer
#19
Stephen W Duffy, Oliver W E Morrish, Prue C Allgood, Richard Black, Maureen G C Gillan, Paula Willsher, Julie Cooke, Karen A Duncan, Michael J Michell, Hilary M Dobson, Roberta Maroni, Yit Y Lim, Hema N Purushothaman, Tamara Suaris, Susan M Astley, Kenneth C Young, Lorraine Tucker, Fiona J Gilbert
BACKGROUND: Mammographic density has been shown to be a strong independent predictor of breast cancer and a causative factor in reducing the sensitivity of mammography. There remain questions as to the use of mammographic density information in the context of screening and risk management, and of the association with cancer in populations known to be at increased risk of breast cancer. AIM: To assess the association of breast density with presence of cancer by measuring mammographic density visually as a percentage, and with two automated volumetric methods, Quantra™ and VolparaDensity™...
November 27, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29188764/assessing-the-performance-of-methodological-search-filters-to-improve-the-efficiency-of-evidence-information-retrieval-five-literature-reviews-and-a-qualitative-study
#20
Carol Lefebvre, Julie Glanville, Sophie Beale, Charles Boachie, Steven Duffy, Cynthia Fraser, Jenny Harbour, Rachael McCool, Lynne Smith
BACKGROUND: Effective study identification is essential for conducting health research, developing clinical guidance and health policy and supporting health-care decision-making. Methodological search filters (combinations of search terms to capture a specific study design) can assist in searching to achieve this. OBJECTIVES: This project investigated the methods used to assess the performance of methodological search filters, the information that searchers require when choosing search filters and how that information could be better provided...
November 2017: Health Technology Assessment: HTA
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