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https://www.readbyqxmd.com/read/29047071/category-effects-on-stimulus-estimation-shifting-and-skewed-frequency-distributions-a-reexamination
#1
Sean Duffy, John Smith
Duffy, Huttenlocher, Hedges, and Crawford (Psychonomic Bulletin & Review, 17(2), 224-230, 2010) report on experiments where participants estimate the lengths of lines. These studies were designed to test the category adjustment model (CAM), a Bayesian model of judgments. The authors report that their analysis provides evidence consistent with CAM: that there is a bias toward the running mean and not recent stimuli. We reexamine their data. First, we attempt to replicate their analysis, and we obtain different results...
October 18, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29046921/pioglitazone-reduces-cold-induced-brown-fat-glucose-uptake-despite-induction-of-browning-in-cultured-human-adipocytes-a-randomised-controlled-trial-in-humans
#2
Rebecca K C Loh, Melissa F Formosa, Nina Eikelis, David A Bertovic, Mitchell J Anderson, Shane A Barwood, Shane Nanayakkara, Neale D Cohen, Andre La Gerche, Anne T Reutens, Kenneth S Yap, Thomas W Barber, Gavin W Lambert, Martin H Cherk, Stephen J Duffy, Bronwyn A Kingwell, Andrew L Carey
AIMS/HYPOTHESIS: Increasing brown adipose tissue (BAT) activity is a possible therapeutic strategy to increase energy expenditure and glucose and lipid clearance to ameliorate obesity and associated comorbidities. The thiazolidinedione (TZD) class of glucose-lowering drugs increase BAT browning in preclinical experimental models but whether these actions extend to humans in vivo is unknown. The aim of this study was to determine the effect of pioglitazone treatment on adipocyte browning and adaptive thermogenesis in humans...
October 18, 2017: Diabetologia
https://www.readbyqxmd.com/read/29046554/the-veiled-ecological-danger-of-rising-sea-levels
#3
Steven L Chown, Grant A Duffy
No abstract text is available yet for this article.
September 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/29046430/path-perturbation-detection-tasks-reduce-mstd-neuronal-self-movement-heading-responses
#4
William K Page, Charles J Duffy
We presented optic flow and real movement heading stimuli while recording MSTd neuronal activity. Monkeys were alternately engaged in three tasks: visual detection of optic flow heading perturbations, vestibular detection of real movement heading perturbations, and auditory detection of brief tones. Push-button RTs were fastest for tones, and slower for visual and vestibular heading perturbations, suggesting that the tone detection task was easier. Neuronal heading selectivity was strongest during the tone detection task, and weaker during the visual and vestibular heading perturbation detection tasks...
October 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29044588/a-uniform-method-for-the-simultaneous-blood-group-phenotyping-of-fy-a-fy-b-jk-a-jk-b-s-s%C3%AC-p1-k-applying-lateral-flow-technique
#5
A Caesar, S Meyer, N Trost, K Neuenschwander, C Geisen, B M Frey, C Gassner, P Schwind
BACKGROUND AND OBJECTIVES: A lateral flow assay for simultaneous blood group typing of ABO, RhD, C, E, c, e, Cw and K with stable end-point and without centrifugation is in routine use since several years (MDmulticard(®) ). The typing of extended phenotype parameters belonging to the Duffy, Kidd, MNSs blood group systems and others, however, has not yet been demonstrated for this technique. Reliable detection of Fy(x) , a weak Fy(b) phenotype with a pronounced quantitative reduction of the number of Fy(b) antigens on the erythrocyte surface, remains a weakness of current serological blood grouping techniques...
October 16, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29043830/red-blood-cell-phenotype-prevalence-in-blood-donors-who-self-identify-as-hispanic
#6
Chelsea A Sheppard, Nicole L Bolen, Beth Eades, Gorka Ochoa-Garay, Mark H Yazer
Molecular genotyping platforms provide a quick, high-throughput method for identifying red blood cell units for patients on extended phenotype-matching protocols, such as those with sickle cell disease or thalassemia. Most of the antigen prevalence data reported are for non-Hispanic populations. Therefore, this study sought to determine the phenotype prevalence in a single blood center's Hispanic population and to compare those results with previously reported rates in non-Hispanic donor populations. We performed a retrospective review of all serologic and molecular typing from donors who self-reported as Hispanic...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29043827/stability-guidelines-for-dithiothreitol-treated-red-blood-cell-reagents-used-for-antibody-detection-methods-in-patients-treated-with-daratumumab
#7
Wendy L Disbro
Daratumumab (DARA), a drug used to treat patients with multiple myeloma, causes interference in pre-transfusion testing. Samples from patients receiving DARA exhibit panreactivity in antibody detection and identification tests with red blood cells (RBCs). Many hospitals are sending these samples to reference laboratories. Dithiothreitol (DTT), a sulfhydryl chemical treatment of RBCs, negates this reactivity. This study investigated the stability of the antigens on DTT-treated RBCs to determine if large quantities of RBCs could be treated at one time, stored, and used for testing at a later time...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29043613/the-chromosome-transmission-fidelity-assay-for-measuring-chromosome-loss-in-yeast
#8
Supipi Duffy, Philip Hieter
The budding yeast Saccharomyces cerevisiae has served as an excellent model system for studying highly conserved biological pathways including pathways involved in genome transmission and maintenance. The Chromosome Transmission Fidelity (CTF) colony color assay was developed to assess chromosome instability (CIN) in yeast, by monitoring the loss or gain during cell division of an artificial chromosome fragment carrying a visual marker. The CTF assay monitors changes in chromosome number, allowing the detection of mutants that exhibit increased rates of chromosome nondisjunction or chromosome loss...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29040338/classifying-dermoscopic-patterns-of-naevi-in-a-case-control-study-of-melanoma
#9
Seamus R McWhirter, David L Duffy, Katie J Lee, Glen Wimberley, Philip McClenahan, Natalie Ling, Marco Ardigo, Helmut Schaider, H Peter Soyer, Richard A Sturm
Changes in dermoscopic patterns of naevi may be associated with melanoma; however, there is no consensus on which dermoscopic classification system is optimal. To determine whether different classification systems give comparable results and can be combined for analysis, we applied two systems to a case-control study of melanoma with 1037 participants: 573 classified using a "1/3 major feature" system, 464 classified based on rules of appearance, and 263 classified with both criteria. There was strong correlation for non-specific (Spearman R = 0...
2017: PloS One
https://www.readbyqxmd.com/read/29038118/introduction-to-chronobiology
#10
Sandra J Kuhlman, L Michon Craig, Jeanne F Duffy
A diverse range of species, from cyanobacteria to humans, evolved endogenous biological clocks that allow for the anticipation of daily variations in light and temperature. The ability to anticipate regular environmental rhythms promotes optimal performance and survival. Herein we present a brief historical timeline of how circadian concepts and terminology have emerged since the early observation of daily leaf movement in plants made by an astronomer in the 1700s.
October 16, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29030992/inadequate-safety-reporting-in-pre-eclampsia-trials-a-systematic-evaluation
#11
James M N Duffy, Martin Hirsch, Louise Pealing, Marian Showell, Khalid S Khan, Sue Ziebland, Richard J McManus
BACKGROUND: Randomised trials and their syntheses in meta-analyses offer a unique opportunity to assess the frequency and severity of adverse reactions. OBJECTIVE: To assess safety reporting in pre-eclampsia trials. SEARCH STRATEGY: Systematic search using bibliographic databases, including Cochrane Central Register of Controlled Trials, Embase, and MEDLINE, from inception to August 2017. SELECTION CRITERIA: Randomised trials evaluating anticonvulsant or antihypertensive medication for pre-eclampsia...
October 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29024716/accelerated-humoral-renal-allograft-rejection-due-to-hla-c14-mediated-allosensitization-to-hla-bw6
#12
Stephen P Persaud, Brian Duffy, Donna L Phelan, Thalachallour Mohanakumar, Rowena Delos Santos, Joseph P Gaut, Chang Liu
OBJECTIVES: To investigate immunological mechanisms underlying accelerated antibody-mediated rejection (AMR) of a living-related renal allograft in a patient with no detectable antibodies to donor human leukocyte antigens (HLA) in pre-transplant sera. METHODS: Pre- and post-transplant HLA antibody specificities were determined by single-antigen bead assay, and crossmatching was performed by flow cytometry- and complement-dependent cytotoxicity-based methods. Intermediate- and high-resolution HLA typing were performed by molecular methods...
October 9, 2017: Human Immunology
https://www.readbyqxmd.com/read/29023717/recovery-from-the-anatomical-effects-of-long-term-monocular-deprivation-in-cat-lateral-geniculate-nucleus
#13
Kevin R Duffy, Ming-Fai Fong, Donald E Mitchell, Mark F Bear
Monocular deprivation (MD) imposed early in postnatal life elicits profound structural and functional abnormalities throughout the primary visual pathway. The ability of MD to modify neurons within the visual system is restricted to a so-called critical period that, for cats, peaks at about one postnatal month and declines thereafter so that by about 3 months of age MD has little effect. Recovery from the consequences of MD likewise adheres to a critical period that ends by about 3 months of age, after which the effects of deprivation are thought to be permanent and without capacity for reversal...
October 11, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29020221/systemic-inflammatory-response-to-malaria-during-pregnancy-is-associated-with-pregnancy-loss-and-preterm-delivery
#14
Michal Fried, Jonathan D Kurtis, Bruce Swihart, Sunthorn Pond-Tor, Amadou Barry, Youssoufa Sidibe, Santara Gaoussou, Moussa Traore, Sekouba Keita, Almahamoudou Mahamar, Oumar Attaher, Adama B Dembele, Kadidia B Cisse, Bacary S Diarra, Moussa B Kanoute, Alassane Dicko, Patrick E Duffy
Background: Pregnancy malaria (PM) is associated with a proinflammatory immune response characterized by increased levels of cytokines and chemokines such as tumor necrosis factor-α, interferon-γ, interleukin 10 (IL-10), and CXCL9. These changes are associated with poor outcomes including low birthweight delivery and maternal anemia. However, it is unknown if inflammatory pathways during malaria are related to pregnancy loss and preterm delivery (PTD). Methods: Cytokine and chemokine levels were measured in maternal peripheral blood at enrollment, gestational week 30-32, and delivery, and in placental blood, of 638 women during a longitudinal cohort study in Ouelessebougou, Mali...
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28991844/criterion-based-assessment-in-a-norm-based-world-how-can-we-move-past-grades
#15
Anne G Pereira, Majka Woods, Andrew P J Olson, Suzanne van den Hoogenhof, Briar L Duffy, Robert Englander
In the United States, the medical education community has begun a shift from the Flexnerian time-based model to a competency-based medical education model. The graduate medical education (GME) community is substantially farther along in this transition than is the undergraduate medical education (UME) community.GME has largely adopted the use of competencies and their attendant milestones and increasingly is employing the framework of entrustable professional activities (EPAs) to assess trainee competence. The UME community faces several challenges to successfully navigating a similar transition...
October 3, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28990906/plasmodium-vivax-infection-in-duffy-negative-people-in-africa
#16
Peter A Zimmerman
No abstract text is available yet for this article.
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28988174/the-prognostic-significance-of-smoking-cessation-after-acute-coronary-syndromes-an-observational-multicentre-study-from-the-melbourne-interventional-group-registry
#17
Matias B Yudi, Omar Farouque, Nick Andrianopoulos, Andrew E Ajani, Katie Kalten, Angela L Brennan, Jeffrey Lefkovits, Chin Hiew, Ernesto Oqueli, Christopher M Reid, Stephen J Duffy, David J Clark
OBJECTIVE: We aim to ascertain the prognostic significance of persistent smoking and smoking cessation after an acute coronary syndrome (ACS) in the era of percutaneous coronary intervention (PCI) and optimal secondary prevention pharmacotherapy. METHODS: Consecutive patients from the Melbourne Interventional Group registry (2005-2013) who were alive at 30 days post-ACS presentation were included in our observational cohort study. Patients were divided into four categories based on their smoking status: non-smoker; ex-smoker (quit >1 month before ACS); recent quitter (smoker at presentation but quit by 30 days) and persistent smoker (smoker at presentation and at 30 days)...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28984865/malaria-in-pregnancy-the-relevance-of-animal-models-for-vaccine-development
#18
Justin Doritchamou, Andrew Teo, Michal Fried, Patrick E Duffy
Malaria during pregnancy due to Plasmodium falciparum or P. vivax is a major public health problem in endemic areas, with P. falciparum causing the greatest burden of disease. Increasing resistance of parasites and mosquitoes to existing tools, such as preventive antimalarial treatments and insecticide-treated bed nets respectively, is eroding the partial protection that they offer to pregnant women. Thus, development of effective vaccines against malaria during pregnancy is an urgent priority. Relevant animal models that recapitulate key features of the pathophysiology and immunology of malaria in pregnant women could be used to accelerate vaccine development...
October 6, 2017: Lab Animal
https://www.readbyqxmd.com/read/28983206/response-to-phrase-truncation-in-pubmed-searches
#19
COMMENT
Steven Duffy, Shelley de Kock, Kate Misso, Caro Noake, Janine Ross, Lisa Stirk
No abstract text is available yet for this article.
October 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28978474/precocious-interleukin-21-expression-in-naive-mice-identifies-a-natural-helper-cell-population-in-autoimmune-disease
#20
Elisabeth A Marnik, Xulong Wang, Thomas J Sproule, Giljun Park, Gregory J Christianson, Sarah Kate Lane-Reticker, Shweta Jain, Theodore Duffy, Hongsheng Wang, Gregory W Carter, Herbert C Morse, Derry C Roopenian
Interleukin 21 (IL-21) plays key roles in humoral immunity and autoimmune diseases. It is known to function in mature CD4(+) T follicular B cell helper (TFH) cells, but its potential involvement in early T cell ontogeny is unclear. Here, we find that a significant population of newly activated thymic and peripheral CD4(+) T cells functionally expresses IL-21 soon after birth. This naturally occurring population, termed natural (n)TH21 cells, exhibits considerable similarity to mature TFH cells. nTH21 cells originating and activated in the thymus are strictly dependent on autoimmune regulator (AIRE) and express high levels of NUR77, consistent with a bias toward self-reactivity...
October 3, 2017: Cell Reports
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