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Sarah Kidd, Virginia B Bowen, Elizabeth A Torrone, Gail Bolan
BACKGROUND: Recent increases in reported congenital syphilis have led to an urgent need to identify interventions that will have the greatest impact on congenital syphilis prevention. We sought to create a congenital syphilis prevention cascade using national syphilis surveillance data to (1) estimate the proportion of potential congenital syphilis cases averted with current prevention efforts, and (2) develop a classification framework to better describe why reported cases were not averted...
March 14, 2018: Sexually Transmitted Diseases
Irena F Creed, Ann-Kristin Bergström, Charles G Trick, Nancy B Grimm, Dag O Hessen, Jan Karlsson, Karen A Kidd, Emma Kritzberg, Diane M McKnight, Erika C Freeman, Oscar E Senar, Agneta Andersson, Jenny Ask, Martin Berggren, Mehdi Cherif, Reiner Giesler, Erin R Hotchkiss, Pirkko Kortelainen, Monica M Palta, Tobias Vrede, Gesa A Weyhenmeyer
Northern ecosystems are experiencing some of the most dramatic impacts of global change on Earth. Rising temperatures, hydrological intensification, changes in atmospheric acid deposition and associated acidification recovery, and changes in vegetative cover are resulting in fundamental changes in terrestrial-aquatic biogeochemical linkages. The effects of global change are readily observed in alterations in the supply of dissolved organic matter (DOM) - the messenger between terrestrial and lake ecosystems - with potentially profound effects on the structure and function of lakes...
March 15, 2018: Global Change Biology
Maureen H Murray, Anjelika D Kidd, Shannon E Curry, Jeffrey Hepinstall-Cymerman, Michael J Yabsley, Henry C Adams, Taylor Ellison, Catharine N Welch, Sonia M Hernandez
Many wildlife species shift their diets to use novel resources in urban areas. The consequences of these shifts are not well known, and consumption of reliable-but low quality-anthropogenic food may present important trade-offs for wildlife health. This may be especially true for carnivorous species such as the American white ibis ( Eudocimus albus ), a nomadic wading bird which has been increasingly observed in urban parks in South Florida, USA. We tested the effects of anthropogenic provisioning on consumer nutrition (i...
May 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Susan Cha, James M Matthias, Mohammad Rahman, Julia A Schillinger, Bruce W Furness, River A Pugsley, Sarah Kidd, Kyle T Bernstein, Thomas A Peterman
BACKGROUND: Health departments prioritize investigations of reported reactive serologic tests based on age, sex, and titer using reactor grids. We wondered how reactor grids are used in different programs, and if administratively closing investigations of low-titer tests could lead to missed primary syphilis cases. METHODS: We obtained a convenience sample of reactor grids from 13 health departments. Interviews with staff from several jurisdictions described the role of grids in surveillance and intervention...
March 9, 2018: Sexually Transmitted Diseases
F Scheffler, S Kilian, B Chiliza, L Asmal, L Phahladira, S du Plessis, M Kidd, R M Murray, M Di Forti, S Seedat, R Emsley
While acute cannabis use stimulates appetite, general population studies suggest that chronic use is associated with reduced risk of obesity and other cardiometabolic risk factors. In this study we investigated changes in body mass index (BMI), fasting blood glucose and lipids, and rates of metabolic syndrome risk factors in cannabis users vs. non-users in 109 minimally treated patients with first-episode schizophrenia, schizophreniform or schizo-affective disorder who were treated according to a standardized treatment regime with depot antipsychotic medication over 12 months...
March 6, 2018: Schizophrenia Research
L B Lopes, C C Abreu, C F Souza, L E R Guimaraes, A A Silva, F Aguiar-Alves, K O Kidd, S Kmoch, A J Bleyer, J R Almeida
Autosomal dominant tubulointerstitial kidney disease (ADTKD) is characterized by autosomal dominant inheritance, progressive chronic kidney disease, and a bland urinary sediment. ADTKD is most commonly caused by mutations in the UMOD gene encoding uromodulin (ADTKD-UMOD). We herein report the first confirmed case of a multi-generational Brazilian family with ADTKD-UMOD, caused by a novel heterozygous mutation (c.163G>A, GGC→AGC, p.Gly55Ser) in the UMOD gene. Of 41 family members, 22 underwent genetic analysis, with 11 individuals found to have this mutation...
March 1, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Peter A Larson, John B Moldovan, Naveen Jasti, Jeffrey M Kidd, Christine R Beck, John V Moran
Human Long interspersed element-1 (L1) retrotransposons contain an internal RNA polymerase II promoter within their 5' untranslated region (UTR) and encode two proteins, (ORF1p and ORF2p) required for their mobilization (i.e., retrotransposition). The evolutionary success of L1 relies on the continuous retrotransposition of full-length L1 mRNAs. Previous studies identified functional splice donor (SD), splice acceptor (SA), and polyadenylation sequences in L1 mRNA and provided evidence that a small number of spliced L1 mRNAs retrotransposed in the human genome...
March 5, 2018: PLoS Biology
Shazia Moeen, Nazish Farooq, Romana Irshad, Muhammad Ashfaq, Umer Farooq, Muhammad Idris
BACKGROUND: Lifelong transfusions are life savers for thalassaemia patients but are associated with many complications. Alloimmunization is a major problem for blood banks. Antigens of foreign red blood cells induce the formation of antibodies in patients suffering from thalassaemia. The purpose of this study was to examine the frequency of red cell alloantibodies and to express the type of these antibodies in thalassaemia patients. METHODS: Patients that have received multiple transfusions were included in this study...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
Sarah E Kidd, Catriona L Halliday, Arthur J Morris, Sharon C-A Chen
No abstract text is available yet for this article.
February 27, 2018: Pathology
Virginia Best, Jayne B Ahlstrom, Christine R Mason, Elin Roverud, Tyler K Perrachione, Gerald Kidd, Judy R Dubno
The ability to identify who is talking is an important aspect of communication in social situations and, while empirical data are limited, it is possible that a disruption to this ability contributes to the difficulties experienced by listeners with hearing loss. In this study, talker identification was examined under both quiet and masked conditions. Subjects were grouped by hearing status (normal hearing/sensorineural hearing loss) and age (younger/older adults). Listeners first learned to identify the voices of four same-sex talkers in quiet, and then talker identification was assessed (1) in quiet, (2) in speech-shaped, steady-state noise, and (3) in the presence of a single, unfamiliar same-sex talker...
February 2018: Journal of the Acoustical Society of America
Jan Hovener, Andrey N Pravdivtsev, Bryce Kidd, C Russel Bowers, Stefan Glöggler, Kirill V Kovtunov, Markus Plaumann, Rachel Katz-Brull, Kai Buckenmaier, Alexej Jerschow, Francesca Reineri, Thomas Theis, Roman V Shchepin, Shawn Wagner, Niki M M Zacharias, Pratip Bhattacharya, Eduard Y Chekmenev
NMR is one of the most versatile and useful physical effects used for human imaging, chemical analysis and the elucidation of molecular structures. Yet, the full potential of NMR is hardly ever used, because only a small fraction of the nuclear spin ensemble is polarized - i.e. aligned with the applied static magnetic field. This fraction is termed nuclear spin polarization P. As a result, no more than a few parts per million of all nuclear spins effectively contribute to the signal in all magnetic fields (B0) available for NMR or MRI today...
February 27, 2018: Angewandte Chemie
Lisa Bodei, Mark S Kidd, Aviral Singh, Wouter A van der Zwan, Stefano Severi, Ignat A Drozdov, Jaroslaw Cwikla, Richard P Baum, Dik J Kwekkeboom, Giovanni Paganelli, Eric P Krenning, Irvin M Modlin
BACKGROUND: Peptide receptor radionuclide therapy (PRRT) utilizes somatostatin receptor (SSR) overexpression on neuroendocrine tumors (NET) to deliver targeted radiotherapy. Intensity of uptake at imaging is considered related to efficacy but has low sensitivity. A pretreatment strategy to determine individual PRRT response remains a key unmet need. NET transcript expression in blood integrated with tumor grade provides a PRRT predictive quotient (PPQ) which stratifies PRRT "responders" from "non-responders"...
February 26, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Shaun Lawicki, Emily A Coberly, Laura A Lee, Mary Johnson, Quentin Eichbaum
BACKGROUND: The Kidd-null phenotype, Jk(a-b-), occurs in individuals who do not express the JK glycoprotein. Jk(a-b-) individuals can make an antibody against the Jk3 antigen, a high-incidence antigen present in more than 99.9% of most populations. This presents many challenges to the blood bank including identification of the antibody, masking of other antibodies, and how to provide transfusion support given the rarity of Jk3-negative blood products. Kidd antibodies may cause acute and delayed hemolytic reactions as well as hemolytic disease of the fetus and newborn (HDFN)...
February 25, 2018: Transfusion
Zheng Wang, Guanglin He, Tao Luo, Xueying Zhao, Jing Liu, Mengge Wang, Di Zhou, Xu Chen, Chengtao Li, Yiping Hou
The Tibeto-Burman language, one subfamily of the Sino-Tibetan languages, is spoken by over 60 million people all over East Asia. Yet the ethnic origin and genetic architecture of Tibeto-Burman speaking populations remain largely unexplored. In the present study, 169 Chinese individuals from Tibeto-Burman speaking populations (two ethnic groups: Tibetan and Yi) in four different geographic regions in western China were analyzed using the Precision ID Ancestry Panel (165 AISNPs) and the Ion PGM System. The performance and corresponding forensic statistical parameters of this AISNPs panel were investigated...
February 13, 2018: Forensic Science International. Genetics
Tania Pardo, Beatriz Rodríguez-Garrido, Ramez F Saad, Jose Luis Soto-Vázquez, Mariana Loureiro-Viñas, Ángeles Prieto-Fernández, Guillaume Echevarria, Emil Benizri, Petra S Kidd
Nickel (Ni) agromining of ultramafic soils has been proposed as an eco-friendly option for metal recovery, which can also improve the fertility and quality of these low productive soils. The selection of adequate plant species and the analysis of their performance under the different climatic conditions are of interest for optimising the process and evaluating its full viability. A one-year field experiment was carried out to evaluate the viability of the two Ni-hyperaccumulating Mediterranean species, Alyssum murale and Leptoplax emarginata, for agromining purposes in ultramafic soils under a humid-temperate climate...
February 22, 2018: Science of the Total Environment
Andrew C Kidd, Michael McGettrick, Selina Tsim, Daniel L Halligan, Max Bylesjo, Kevin G Blyth
Introduction: Accurate prognostication is difficult in malignant pleural mesothelioma (MPM). We developed a set of robust computational models to quantify the prognostic value of routinely available clinical data, which form the basis of published MPM prognostic models. Methods: Data regarding 269 patients with MPM were allocated to balanced training (n=169) and validation sets (n=100). Prognostic signatures (minimal length best performing multivariate trained models) were generated by least absolute shrinkage and selection operator regression for overall survival (OS), OS <6 months and OS <12 months...
2018: BMJ Open Respiratory Research
Mark Kidd, Irvin M Modlin, Ignat Drozdov, Harry Aslanian, Lisa Bodei, Somer Matar, Kyung-Min Chung
No effective blood biomarker exists to detect and clinically manage bronchopulmonary (BP) neuroendocrine tumors (NET). We developed a blood-based 51 NET-specific transcript set for diagnosis and monitoring and evaluated clinical performance metrics. It accurately diagnosed the tumor and differentiated stable from progressive disease as determined by RECIST criteria. Gene expression was evaluated in: a) publicly available BPNET transcriptomes (GSE35679); b) two BPNET cell-lines; and c) BPNET tissue with paired blood ( n = 7)...
January 23, 2018: Oncotarget
Sarah Kidd, Elizabeth Torrone, John Su, Hillard Weinstock
BACKGROUND: Recent increases in syphilis among men who have sex with men (MSM) are especially concerning, given the biologic and epidemiologic associations between syphilis and HIV infection. We sought to better describe the current epidemiology of primary and secondary (P&S) syphilis and the prevalence of HIV infection among reported P&S syphilis cases by demographic group, including sex of sex partner, in the United States in 2016. METHODS: We reviewed national P&S syphilis case report data from 2016, including available risk factor information such as sex of sex partner and HIV status...
February 15, 2018: Sexually Transmitted Diseases
Chloe Kidd, Natalie J Loxton
The current study aimed to identify how underlying individual differences increases vulnerability to television food advertising. In particular, this study examined how reward sensitivity, a biologically-based predisposition to approach rewards (such as appetitive foods) in the environment, influenced participants' vulnerability to television food advertising and subsequent food consumption. Ninety-eight participants were randomly assigned to a cue condition (food cues versus non-food cues) and then viewed a 30 min documentary interrupted by advertising featuring a mix of food and neutral advertising (food cue condition) or only neutral advertising (non-food cue condition)...
February 16, 2018: Physiology & Behavior
Andrew J Stollenwerk, Eric Clausen, Matthew Cook, Keith Doore, Ryan Holzapfel, Jacob Weber, Rui He, Timothy E Kidd
Ultrasonic agitation is a proven method for breaking down layered materials such as MoS2 into single or few layer nanoparticles. In this experiment, MoS2 powder is sonicated in isopropanol for an extended period of time in an attempt to create particles of the smallest possible size. As expected, the process yielded a significant quantity of nanoscale MoS2 in the form of finite layer sheets with lateral dimensions as small as a few tens of nanometers. Although no evidence was found to indicate a larger the longer sonication times resulted in a significant increase in yield of single layer MoS2, the increased sonication did result in the formation of several types of carbon allotropes in addition to the sheets of MoS2...
May 1, 2018: Journal of Nanoscience and Nanotechnology
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