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https://www.readbyqxmd.com/read/28070634/increasing-the-reference-populations-for-the-55-aisnp-panel-the-need-and-benefits
#1
Andrew J Pakstis, Longli Kang, Lijun Liu, Zhiying Zhang, Tianbo Jin, Elena L Grigorenko, Frank R Wendt, Bruce Budowle, Sibte Hadi, Mariam Salam Al Qahtani, Niels Morling, Helle Smidt Mogensen, Goncalo E Themudo, Usha Soundararajan, Haseena Rajeevan, Judith R Kidd, Kenneth K Kidd
Ancestry inference for an individual can only be as good as the reference populations with allele frequency data on the SNPs being used. If the most relevant ancestral population(s) does not have data available for the SNPs studied, then analyses based on DNA evidence may indicate a quite distantly related population, albeit one among the more closely related of the existing reference populations. We have added reference population allele frequencies for 14 additional population samples (with >1100 individuals studied) to the 125 population samples previously published for the Kidd Lab 55 AISNP panel...
January 9, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28069305/use-of-plant-growth-promoting-bacterial-strains-to-improve-cytisus-striatus-and-lupinus-luteus-development-for-potential-application-in-phytoremediation
#2
María Balseiro-Romero, Panagiotis Gkorezis, Petra S Kidd, Jonathan Van Hamme, Nele Weyens, Carmen Monterroso, Jaco Vangronsveld
Plant growth promoting (PGP) bacterial strains possess different mechanisms to improve plant development under common environmental stresses, and are therefore often used as inoculants in soil phytoremediation processes. The aims of the present work were to study the effects of a collection of plant growth promoting bacterial strains on plant development, antioxidant enzyme activities and nutritional status of Cytisus striatus and/or Lupinus luteus plants a) growing in perlite under non-stress conditions and b) growing in diesel-contaminated soil...
January 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28065763/the-kidd-jk-blood-group-system
#3
REVIEW
Shaun Lawicki, Randal B Covin, Amy A Powers
The Kidd blood group system was discovered in 1951 and is composed of 2 antithetical antigens, Jk(a) and Jk(b), along with a third high-incidence antigen, Jk3. The Jk3 antigen is expressed in all individuals except those with the rare Kidd-null phenotype. Four Kidd phenotypes are therefore possible: Jk(a+b-), Jk(a-b+), Jk(a+b+), and Jk(a-b-). The glycoprotein carrying the Kidd antigens is a 43-kDa, 389-amino acid protein with 10 membrane-spanning domains which functions as a urea transporter on endothelial cells of the renal vasa recta as well as erythrocytes...
November 9, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28051114/novel-therapeutics-identification-for-fibrosis-in-renal-allograft-using-integrative-informatics-approach
#4
Li Li, Ilana Greene, Benjamin Readhead, Madhav C Menon, Brian A Kidd, Andrew V Uzilov, Chengguo Wei, Nimrod Philippe, Bernd Schroppel, John Cijiang He, Rong Chen, Joel T Dudley, Barbara Murphy
Chronic allograft damage, defined by interstitial fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure. Few effective therapeutic options are available to prevent the progression of IF/TA. We applied a meta-analysis approach on IF/TA molecular datasets in Gene Expression Omnibus to identify a robust 85-gene signature, which was used for computational drug repurposing analysis. Among the top ranked compounds predicted to be therapeutic for IF/TA were azathioprine, a drug to prevent acute rejection in renal transplantation, and kaempferol and esculetin, two drugs not previously described to have efficacy for IF/TA...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28049708/modeling-human-population-separation-history-using-physically-phased-genomes
#5
Shiya Song, Elzbieta Sliwerska, Sarah Emery, Jeffrey M Kidd
Phased haplotype sequences are a key component in many population genetic analyses since variation in haplotypes reflects the action of recombination, selection, and changes in population size. In humans, haplotypes are typically estimated from unphased sequence or genotyping data using statistical models applied to large reference panels. To assess the importance of correct haplotype phase on population history inference, we performed fosmid pool sequencing and resolved phased haplotypes of five individuals from diverse African populations (including Yoruba, Esan, Gambia, Maasai, and Mende)...
January 2017: Genetics
https://www.readbyqxmd.com/read/28032616/electronic-structure-of-multi-walled-carbon-fullerenes
#6
Keith Doore, Matthew Cook, Eric Clausen, Pavel V Lukashev, Tim E Kidd, Andrew J Stollenwerk
Despite an enormous amount of research on carbon based nanostructures, relatively little is known about the electronic structure of multi-walled carbon fullerenes, also known as carbon onions. In part, this is due to the very high computational expense involved in estimating electronic structure of large molecules. At the same time, experimentally, the exact crystal structure of the carbon onion is usually unknown, and therefore one relies on qualitative arguments only. In this work we present the results of a computational study on a series of multi-walled fullerenes and compare their electronic structures to experimental data...
February 22, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28024253/language-use-statistics-and-prototypical-grapheme-colours-predict-synaesthetes-and-non-synaesthetes-word-colour-associations
#7
Stephanie C Goodhew, Evan Kidd
Synaesthesia is the neuropsychological phenomenon in which individuals experience unusual sensory associations, such as experiencing particular colours in response to particular words. While it was once thought the particular pairings between stimuli were arbitrary and idiosyncratic to particular synaesthetes, there is now growing evidence for a systematic psycholinguistic basis to the associations. Here we sought to assess the explanatory value of quantifiable lexical association measures (via latent semantic analysis; LSA) in the pairings observed between words and colours in synaesthesia...
December 23, 2016: Acta Psychologica
https://www.readbyqxmd.com/read/28011157/increased-identification-of-candidates-for-high-risk-breast-cancer-screening-through-expanded-genetic-testing
#8
Eric T Rosenthal, Brent Evans, John Kidd, Krystal Brown, Heidi Gorringe, Michael van Orman, Susan Manley
PURPOSE: Breast MRI screening is recommended for women with a >20% lifetime risk for breast cancer on the basis of estimates derived from risk models dependent largely on family history. Alternatively, a >20% lifetime risk can be established through genetic testing of BRCA1 and BRCA2, as well as a growing selection of other genes associated with inherited breast cancer risk. The aim of this study was to quantify the impact of testing for genes other than BRCA1/2 and the extent to which mutation carriers in these genes would have been identified as candidates for enhanced screening on the basis of family history alone...
December 20, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28007780/ficin-treated-red-cells-help-identify-clinically-significant-alloantibodies-masked-as-reactions-of-undetermined-specificity-in-gel-microtubes
#9
Ben C Hill, Courtney A Hanna, Jill Adamski, Huy P Pham, Marisa B Marques, Lance A Williams
Non-specific antibodies or antibodies of undetermined significance (AUS) often pose problems for a blood bank technologist and physician. It is well known that antibodies can weaken and evanesce over time, thus eluding detection by routine blood bank techniques. Special enhancement techniques exist (eg, ficin treatment); however, they are often underutilized due to concerns over expense. Ficin is known to enhance reactivity caused by antibodies in the ABO, Rh, Kidd, Lewis, I, and P blood group systems, while destroying reactivity of antibodies in the Duffy, and MNS blood group systems...
December 22, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27999143/aspirin-use-and-reduced-risk-of-pancreatic-cancer
#10
Harvey A Risch, Lingeng Lu, Samantha A Streicher, Jing Wang, Wei Zhang, Quanxing Ni, Mark S Kidd, Herbert Yu, Yu-Tang Gao
BACKGROUND: Few options besides the avoidance of smoking and obesity are available to prevent pancreatic cancer. The association between aspirin use and risk of pancreatic cancer has been inconsistent across studies. METHODS: We performed a population-based study of 761 case and 794 control subjects frequency matched on sex and age during 2006 to 2011 in Shanghai, China. Participants were asked about episodes of regular use of aspirin, tablets per day or week, and ages that the use started and stopped...
January 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27995865/the-molecular-epidemiology-of-pseudomonas-aeruginosa-bloodstream-infection-isolates-in-a-non-outbreak-setting
#11
Kate L McCarthy, Tim J Kidd, David L Paterson
The molecular epidemiology of Pseudomonas aeruginosa bloodstream infection (BSI) isolates has received limited attention. This study aims to characterise the molecular relationship of P. aeruginosa bloodstream infection isolates in the non-outbreak setting at a single tertiary healthcare facility. P. aeruginosa BSI isolates from patients who were admitted to the Royal Brisbane and Women's Hospital over a 13 month period from November 2009 were identified retrospectively from the Pathology Queensland Clinical and Scientific Information System...
December 19, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27995435/beliefs-in-antiretroviral-treatment-and-self-efficacy-in-hiv-management-are-associated-with-distinctive-hiv-treatment-trajectories
#12
Limin Mao, John de Wit, Philippe Adam, Jeffrey J Post, Sean Slavin, Aaron Cogle, Edwina Wright, Michael Kidd
An online survey was conducted among people living with HIV (PLHIV) in Australia to discern key factors associated with distinctive ART use patterns. The sample (N = 358), was further divided into three groups: those on ART continuously since initiation (n = 208, 58.1%); those on ART intermittently (n = 117, 32.7%); and those not on ART at the time of survey (n = 33, 9.2%). ART non-users were the most likely to hold serious concerns about ART that outweighed perceived necessities (benefits) from ART (AOR = 0...
December 19, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27995319/prediction-of-biogeographical-ancestry-from-genotype-a-comparison-of-classifiers
#13
Elaine Y Y Cheung, Michelle Elizabeth Gahan, Dennis McNevin
DNA can provide forensic intelligence regarding a donor's biogeographical ancestry (BGA) and other externally visible characteristics (EVCs). A number of algorithms have been proposed to assign individual human genotypes to a BGA using ancestry informative marker (AIM) panels. This study compares the BGA assignment accuracy of the population clustering program STRUCTURE and three generic classification approaches including a Bayesian algorithm, genetic distance, and multinomial logistic regression (MLR). A selection of 142 ancestry informative single nucleotide polymorphisms (SNPs) were chosen from existing marker panels (SNPforID 34-plex, Eurasiaplex, Seldin, and Kidd's AIM panels) to assess BGA classification at the continental level for Africans, Europeans, East Asians, and Amerindians...
December 20, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27989886/intracoronary-imaging-cholesterol-efflux-and-transcriptomes-after-intensive-statin-treatment-the-yellow-ii-study
#14
Annapoorna S Kini, Yuliya Vengrenyuk, Khader Shameer, Akiko Maehara, Meerarani Purushothaman, Takahiro Yoshimura, Mitsuaki Matsumura, Melissa Aquino, Nezam Haider, Kipp W Johnson, Ben Readhead, Brian A Kidd, Jonathan E Feig, Prakash Krishnan, Joseph Sweeny, Milind Mahajan, Pedro Moreno, Roxana Mehran, Jason C Kovacic, Usman Baber, Joel T Dudley, Jagat Narula, Samin Sharma
BACKGROUND: Despite the extensive evidence for the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects in remain elusive. OBJECTIVES: To assess the changes in plaque morphology by intravascular imaging with a comprehensive evaluation of cholesterol efflux capacity (CEC) and peripheral blood mononuclear cells (PBMC) transcriptomics in patients receiving high-dose statin therapy. METHODS: In a prospective study, 85 patients with stable multivessel coronary artery disease underwent percutaneous coronary intervention for a culprit lesion followed by intracoronary multi-modality imaging including optical coherence tomography (OCT) of an obstructive non-culprit lesion (NCL)...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970520/cost-effectiveness-of-brivaracetam-versus-other-antiepileptic-drugs-used-as-adjunctive-treatment-for-focal-seizures-in-the-uk-a-discrete-event-simulation-model
#15
M Charokopou, J Sander, R Saha, S Beard, R Kidd, E Coward, J Plumb
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27969045/the-experience-of-weight-management-in-normal-weight-adults
#16
Cheri Ann Hernandez, David A Hernandez, Christine M Wellington, Art Kidd
BACKGROUND: No prior research has been done with normal weight persons specific to their experience of weight management. PURPOSE: The purpose of this research was to discover the experience of weight management in normal weight individuals. METHOD: Glaserian grounded theory was used. Qualitative data (focus group) and quantitative data (food diary, study questionnaire, and anthropometric measures) were collected. DISCUSSION: Weight management was an ongoing process of trying to focus on living (family, work, and social), while maintaining their normal weight targets through five consciously and unconsciously used strategies...
November 2016: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/27968830/availability-and-use-of-primary-care-facilities-in-china-a-nationwide-representative-survey
#17
William C W Wong, Sunfang Jiang, Jason Ong, Minghui Peng, Eric Wan, Zhanshu Zhu, Cindy L K Lam, Michael Kidd, Martin Roland
BACKGROUND: China introduced a national policy to develop primary care in 2009, with 8669 community health centres (CHCs) established by 2014, employing more than 300 000 staff. However, against a background of the "barefoot doctor" legacy in rural China, mistrust of doctors, and over-reliance on specialist care, these facilities have been underused. This study aimed to evaluate the current quality of CHCs in China, including the organisation and infrastructure, as well as the use and training of the health-care professionals within primary care...
October 2016: Lancet
https://www.readbyqxmd.com/read/27958660/angiotensin-ii-reduces-the-surface-abundance-of-kv1-5-channels-in-arterial-myocytes-to-stimulate-vasoconstriction
#18
Michael W Kidd, Simon Bulley, Jonathan H Jaggar
Smooth muscle cells (myocytes) of resistance-size arteries express several different voltage-dependent K(+) (KV ) channels, including KV 1.5 and KV 2.1, which regulate contractility. Myocyte KV currents are inhibited by vasoconstrictors, including angiotensin II (Ang II), but mechanisms involved are unclear. Here, we tested the hypothesis that Ang II inhibits KV currents by reducing the plasma membrane abundance of KV channels in myocytes. Ang II (2 h) reduced surface and total KV 1.5 protein in rat mesenteric arteries...
December 13, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27939725/response-of-oxidative-stress-transcripts-in-the-brain-of-wild-yellow-perch-perca-flavescens-exposed-to-an-environmental-gradient-of-methylmercury
#19
Stephanie D Graves, Karen A Kidd, Katharina L Batchelar, Andrew M Cowie, Nelson J O'Driscoll, Christopher J Martyniuk
Methylmercury (MeHg) exposure and adverse health effects in fishes have been documented, but the molecular mechanisms involved in toxicity have not been fully characterized. The objectives of the current study were to (1) determine whether total Hg (THg) in the muscle was predictive of MeHg concentrations in the brain of wild female yellow perch (Perca flavescens) collected from four lakes in Kejimkujik National Park, a known biological mercury (Hg) hotspot in Nova Scotia, Canada and (2) to determine whether transcripts involved in the oxidative stress response were altered in abundance in fish collected across five lakes representing a MeHg gradient...
February 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27932831/bernard-geoffrey-norman-smith
#20
E Kidd, L Howe
No abstract text is available yet for this article.
December 9, 2016: British Dental Journal
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