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https://www.readbyqxmd.com/read/28814540/autism-spectrum-disorder-in-fragile-x-syndrome-cooccurring-conditions-and-current-treatment
#1
Walter E Kaufmann, Sharon A Kidd, Howard F Andrews, Dejan B Budimirovic, Amy Esler, Barbara Haas-Givler, Tracy Stackhouse, Catharine Riley, Georgina Peacock, Stephanie L Sherman, W Ted Brown, Elizabeth Berry-Kravis
BACKGROUND AND OBJECTIVE: Individuals with fragile X syndrome (FXS) are frequently codiagnosed with autism spectrum disorder (ASD). Most of our current knowledge about ASD in FXS comes from family surveys and small studies. The objective of this study was to examine the impact of the ASD diagnosis in a large clinic-based FXS population to better inform the care of people with FXS. METHODS: The study employed a data set populated by data from individuals with FXS seen at specialty clinics across the country...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28814539/forward-a-registry-and-longitudinal-clinical-database-to-study-fragile-x-syndrome
#2
Stephanie L Sherman, Sharon A Kidd, Catharine Riley, Elizabeth Berry-Kravis, Howard F Andrews, Robert M Miller, Sharyn Lincoln, Mark Swanson, Walter E Kaufmann, W Ted Brown
BACKGROUND AND OBJECTIVE: Advances in the care of patients with fragile X syndrome (FXS) have been hampered by lack of data. This deficiency has produced fragmentary knowledge regarding the natural history of this condition, healthcare needs, and the effects of the disease on caregivers. To remedy this deficiency, the Fragile X Clinic and Research Consortium was established to facilitate research. Through a collective effort, the Fragile X Clinic and Research Consortium developed the Fragile X Online Registry With Accessible Research Database (FORWARD) to facilitate multisite data collection...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28813024/advances-in-understanding-of-penile-carcinogenesis-the-search-for-actionable-targets
#3
REVIEW
Juan Chipollini, Sharon Chaing, Mounsif Azizi, Laura C Kidd, Patricia Kim, Philippe E Spiess
Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcinoma is the most common variant with distinct precancerous lesions before development into invasive disease. Involvement of the inguinal lymph nodes is the most important prognostic factor in PeCa, and once disease is present outside the groin, prognosis is poor. Metastatic PeCa is challenging to treat and often requires multidisciplinary approaches in management. Due to its rarity, molecular understanding of the disease continues to be limited with most studies based on small, single center series...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28809125/post-chemotherapy-perforation-in-cats-with-discrete-intermediate-or-large-cell-gastrointestinal-lymphoma
#4
Zachary Crouse, Brenda Phillips, Andi Flory, Jennifer Mahoney, Keith Richter, Linda Kidd
Objectives Gastrointestinal (GI) perforation is a well-described complication of GI lymphoma in people, commonly occurring within days of initiation of chemotherapy. There are no studies documenting the prevalence of GI perforation in cats with intermediate- or large-cell GI lymphoma or whether it is associated with induction of chemotherapy. The objectives of this study were to document the prevalence and timing of post-chemotherapy perforation in cats with discrete GI masses caused by intermediate- or large-cell lymphoma...
August 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28808123/-i-didn-t-know-i-needed-a-poet
#5
Monica Kidd
No abstract text is available yet for this article.
August 14, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28802993/microbial-community-structure-and-activity-in-trace-element-contaminated-soils-phytomanaged-by-gentle-remediation-options-gro
#6
M Touceda-González, Á Prieto-Fernández, G Renella, L Giagnoni, A Sessitsch, G Brader, J Kumpiene, I Dimitriou, J Eriksson, W Friesl-Hanl, R Galazka, J Janssen, M Mench, I Müller, S Neu, M Puschenreiter, G Siebielec, J Vangronsveld, P S Kidd
Gentle remediation options (GRO) are based on the combined use of plants, associated microorganisms and soil amendments, which can potentially restore soil functions and quality. We studied the effects of three GRO (aided-phytostabilisation, in situ stabilisation and phytoexclusion, and aided-phytoextraction) on the soil microbial biomass and respiration, the activities of hydrolase enzymes involved in the biogeochemical cycles of C, N, P, and S, and bacterial community structure of trace element contaminated soils (TECS) from six field trials across Europe...
August 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28800337/the-new-zealand-neuromuscular-disease-patient-registry-five-years-and-a-thousand-patients
#7
Miriam J Rodrigues, Gina L O'Grady, Graeme Hammond-Tooke, Alexa Kidd, Donald O Love, Ronelle K Baker, Richard H Roxburgh
The New Zealand Neuromuscular Disease Patient Registry has been recruiting for five years. Its primary aim is to enable people with neuromuscular disease to participate in research including clinical trials. It has contributed data to large anonymised cohort studies and many feasibility studies, and has provided practical information and advice to researchers wanting to work with people with neuromuscular conditions. 1019 people have enrolled since the Registry's launch in August 2011 with over 70 different diagnoses...
August 11, 2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28792943/discovery-of-aspergillus-frankstonensis-sp-nov-during-environmental-sampling-for-animal-and-human-fungal-pathogens
#8
Jessica J Talbot, Jos Houbraken, Jens C Frisvad, Robert A Samson, Sarah E Kidd, John Pitt, Sue Lindsay, Julia A Beatty, Vanessa R Barrs
Invasive fungal infections (IFI) due to species in Aspergillus section Fumigati (ASF), including the Aspergillus viridinutans species complex (AVSC), are increasingly reported in humans and cats. The risk of exposure to these medically important fungi in Australia is unknown. Air and soil was sampled from the domiciles of pet cats diagnosed with these IFI and from a nature reserve in Frankston, Victoria, where Aspergillus viridinutans sensu stricto was discovered in 1954. Of 104 ASF species isolated, 61% were A...
2017: PloS One
https://www.readbyqxmd.com/read/28774723/environments-tune-and-select-cellular-diversity
#9
Brian A Kidd
Technical advances in single-cell sequencing data and their application to greater samples is revealing substantial cell-to-cell variation in expression levels and propagation of this variation between molecules across cells. New quantitative approaches that apply mechanistic and statistical models in a systems-wide approach are illuminating the drivers of phenotypic diversity.
July 31, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/28765355/oxygen-requirements-for-acutely-and-critically-ill-patients
#10
EDITORIAL
Debra Siela, Michelle Kidd
Oxygen administration is often assumed to be required for all patients who are acutely or critically ill. However, in many situations, this assumption is not based on evidence. Injured body tissues and cells throughout the body respond both beneficially and adversely to delivery of supplemental oxygen. Available evidence indicates that oxygen administration is not warranted for patients who are not hypoxemic, and hyperoxia may contribute to increased tissue damage and mortality. Nurses must be aware of implications related to oxygen administration for all types of acutely and critically ill patients...
August 2017: Critical Care Nurse
https://www.readbyqxmd.com/read/28758567/the-benefit-of-a-visually-guided-beamformer-in-a-dynamic-speech-task
#11
Virginia Best, Elin Roverud, Timothy Streeter, Christine R Mason, Gerald Kidd
The aim of this study was to evaluate the performance of a visually guided hearing aid (VGHA) under conditions designed to capture some aspects of "real-world" communication settings. The VGHA uses eye gaze to steer the acoustic look direction of a highly directional beamforming microphone array. Although the VGHA has been shown to enhance speech intelligibility for fixed-location, frontal targets, it is currently not known whether these benefits persist in the face of frequent changes in location of the target talker that are typical of conversational turn-taking...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/28752018/project-house-water-a-novel-interdisciplinary-framework-to-assess-the-environmental-and-socioeconomic-consequences-of-flood-related-impacts
#12
Sarah E Crawford, Catrina Brüll Nee Cofalla, Benedikt Aumeier, Markus Brinkmann, Elisa Classen, Verena Esser, Caroline Ganal, Elena Kaip, Roger Häussling, Frank Lehmkuhl, Peter Letmathe, Anne-Katrin Müller, Ilja Rabinovitch, Klaus Reicherter, Jan Schwarzbauer, Marco Schmitt, Georg Stauch, Matthias Wessling, Süleyman Yüce, Markus Hecker, Karen A Kidd, Rolf Altenburger, Werner Brack, Holger Schüttrumpf, Henner Hollert
Protecting our water resources in terms of quality and quantity is considered one of the big challenges of the twenty-first century, which requires global and multidisciplinary solutions. A specific threat to water resources, in particular, is the increased occurrence and frequency of flood events due to climate change which has significant environmental and socioeconomic impacts. In addition to climate change, flooding (or subsequent erosion and run-off) may be exacerbated by, or result from, land use activities, obstruction of waterways, or urbanization of floodplains, as well as mining and other anthropogenic activities that alter natural flow regimes...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28751241/flexibility-assessment-of-the-unfused-thoracic-segments-above-the-potential-upper-instrumented-vertebra-using-the-supine-side-bending-radiographs-in-lenke-5-and-6-curves-for-adolescent-idiopathic-scoliosis-patients
#13
Mun Keong Kwan, Chee Kidd Chiu, Teik Seng Chan, Siti Mariam Abd Gani, Tan Shurn Heng, Chris Yin Wei Chan
BACKGROUND CONTEXT: Selection of UIV for Lenke 5 and 6 curves remains debatable, and several authors had described different selection strategies. OBJECTIVE: This study analyzed the flexibility of the unfused thoracic segments above the 'potential upper instrumented vertebrae (UIV)' (T1 to T12) and its compensatory ability in Lenke 5 and 6 curves using supine side bending (SSB) radiographs. STUDY DESIGN: Retrospective study PATIENT SAMPLE: 100 patients OUTCOME MEASURES: The ability of the unfused thoracic segments above the 'potential upper instrumented vertebrae (UIV)' i...
July 24, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28751228/consideration-of-patient-and-disease-characteristics-in-selecting-radiation-regimens-for-treatment-of-bone-metastases
#14
Yufei Liu, Rie von Eyben, Elizabeth A Kidd
PURPOSE: Radiation therapy is one of the mainstays of treatment for painful bone metastases; however, the optimal fractionation and dosing of radiation for a given patient and disease characteristics are still subject to debate. METHODS AND MATERIALS: We retrospectively examined 475 patients who received radiation for bone metastases at our institution from 2009 through 2014 and evaluated survival outcomes based on parameters of their first treatment course and patient demographics...
June 23, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28749823/rates-of-primary-and-secondary-syphilis-among-white-and-black-non-hispanic-men-who-have-sex-with-men-us-states-2014
#15
Jeremy A Grey, Kyle T Bernstein, Patrick S Sullivan, Sarah E Kidd, Thomas L Gift, Eric W Hall, Abigail Hankin-Wei, Hillard S Weinstock, Eli S Rosenberg
BACKGROUND: Men who have sex with men (MSM) in the United States experience an approximately 100-fold greater rate of primary and secondary (P&S) syphilis diagnoses compared to men who have sex with women only. As in the general population, racial/ethnic disparities in P&S syphilis diagnosis rates may exist among MSM, but MSM-specific P&S syphilis rates by race/ethnicity are unavailable. We enhanced a published modeling approach to estimate area-level MSM populations by race/ethnicity and provide the first estimates of P&S syphilis among black and white non-Hispanic MSM...
July 26, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28748740/the-use-of-fluoroscopic-guided-percutaneous-pedicle-screws-in-the-upper-thoracic-spine-t1-t6-is-it-safe
#16
Mun Keong Kwan, Chee Kidd Chiu, Chris Yin Wei Chan, Reza Zamani, Nils Hansen-Algenstaedt
PURPOSE: This study analysed the accuracy and safety of the fluoroscopic guided percutaneous screws in the upper thoracic vertebrae (T1-T6). METHODS: Computed tomography scans from 74 patients were retrospectively evaluated between January 2008 and December 2012. Pedicle perforations were classified by two types of grading systems. For medial, lateral, superior and inferior perforations: grade 0 - no violation; grade 1 - <2 mm; grade 2 - 2-4 mm and grade 3 - >4 mm...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28739796/multicenter-and-international-study-of-mic-mec-distributions-for-definition-of-epidemiological-cutoff-values-ecvs-for-species-of-sporothrix-identified-by-molecular-methods
#17
A Espinel-Ingroff, D P B Abreu, R Almeida-Paes, R S N Brilhante, A Chakrabarti, A Chowdhary, F Hagen, S Córdoba, G M Gonzalez, N P Govender, J Guarro, E M Johnson, S E Kidd, S A Pereira, A M Rodrigues, S Rozental, M W Szeszs, R Ballesté Alaniz, A Bonifaz, L X Bonfietti, L P Borba-Santos, J Capilla, A L Colombo, M Dolande, M G Isla, M S C Melhem, A C Mesa-Arango, M M E Oliveira, M M Panizo, Z Pires de Camargo, R M Zancope-Oliveira, J F Meis, J Turnidge
Clinical and Laboratory Standards Institute (CLSI) conditions for testing the susceptibilities of pathogenic Sporothrix species to antifungal agents are based on a collaborative study that evaluated five clinically relevant isolates of Sporothrix schenckii sensu lato and some antifungal agents. With the advent of molecular identification, there are two basic needs: to confirm the suitability of these testing conditions for all agents and Sporothrix species and to establish species-specific epidemiologic cutoff values (ECVs) or breakpoints (BPs) for these species...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28732524/how-to-choose-the-best-journal-for-your-case-report
#18
EDITORIAL
Richard A Rison, Jennifer Kelly Shepphird, Michael R Kidd
Since the establishment of the Journal of Medical Case Reports in 2006, the number of journals that publish case reports has increased rapidly, and most of these journals are open access. Open access publishing usually requires authors to pay publication fees while offering the articles online, free of charge, and free of most copyright and licensing restrictions. The movement for open access has gained support in the research community, with the publishers BioMed Central and PLOS ONE becoming leaders in scientific publishing in their number of articles and citations...
July 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28726808/prevalence-of-germ-line-mutations-in-cancer-genes-among-pancreatic-cancer-patients-with-a-positive-family-history
#19
Kari G Chaffee, Ann L Oberg, Robert R McWilliams, Neil Majithia, Brian A Allen, John Kidd, Nanda Singh, Anne-Renee Hartman, Richard J Wenstrup, Gloria M Petersen
PurposePanel-based genetic testing has identified increasing numbers of patients with pancreatic ductal adenocarcinoma (PDAC) who carry germ-line mutations. However, small sample sizes or number of genes evaluated limit prevalence estimates of these mutations. We estimated prevalence of mutations in PDAC patients with positive family history.MethodsWe sequenced 25 cancer susceptibility genes in lymphocyte DNA from 302 PDAC patients in the Mayo Clinic Biospecimen Resource for Pancreatic Research Registry. Kindreds containing at least two first-degree relatives with PDAC met criteria for familial pancreatic cancer (FPC), while the remaining were familial, but not FPC...
July 20, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28719574/ancient-european-dog-genomes-reveal-continuity-since-the-early-neolithic
#20
Laura R Botigué, Shiya Song, Amelie Scheu, Shyamalika Gopalan, Amanda L Pendleton, Matthew Oetjens, Angela M Taravella, Timo Seregély, Andrea Zeeb-Lanz, Rose-Marie Arbogast, Dean Bobo, Kevin Daly, Martina Unterländer, Joachim Burger, Jeffrey M Kidd, Krishna R Veeramah
Europe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic remains and having been the centre of modern dog breed creation. Here we sequence the genomes of an Early and End Neolithic dog from Germany, including a sample associated with an early European farming community. Both dogs demonstrate continuity with each other and predominantly share ancestry with modern European dogs, contradicting a previously suggested Late Neolithic population replacement. We find no genetic evidence to support the recent hypothesis proposing dual origins of dog domestication...
July 18, 2017: Nature Communications
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