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https://www.readbyqxmd.com/read/28339744/determining-the-analytical-specificity-of-pcr-based-assays-for-the-diagnosis-of-ia-what-is-aspergillus
#1
C Oliver Morton, P Lewis White, Rosemary A Barnes, Lena Klingspor, Manuel Cuenca-Estrella, Katrien Lagrou, Stéphane Bretagne, Willem Melchers, Carlo Mengoli, Angela M Caliendo, Massimo Cogliati, Yvette Debets-Ossenkopp, Rebecca Gorton, Ferry Hagen, Catriona Halliday, Petr Hamal, Kathleen Harvey-Wood, Katia Jaton, Gemma Johnson, Sarah Kidd, Martina Lengerova, Cornelia Lass-Florl, Chris Linton, Laurence Millon, C Orla Morrissey, Melinda Paholcsek, Alida Fe Talento, Markus Ruhnke, Birgit Willinger, J Peter Donnelly, Juergen Loeffler
A wide array of PCR tests has been developed to aid the diagnosis of invasive aspergillosis (IA), providing technical diversity but limiting standardisation and acceptance. Methodological recommendations for testing blood samples using PCR exist, based on achieving optimal assay sensitivity to help exclude IA. Conversely, when testing more invasive samples (BAL, biopsy, CSF) emphasis is placed on confirming disease, so analytical specificity is paramount. This multicenter study examined the analytical specificity of PCR methods for detecting IA by blind testing a panel of DNA extracted from a various fungal species to explore the range of Aspergillus species that could be detected, but also potential cross reactivity with other fungal species...
October 7, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28339302/driver-trust-in-five-driver-assistance-technologies-following-real-world-use-in-four-production-vehicles
#2
David G Kidd, Jessica B Cicchino, Ian J Reagan, Laura B Kerfoot
OBJECTIVES: Information about drivers' experiences with driver assistance technologies in real driving conditions is sparse. This study characterized driver interactions with forward collision warning, adaptive cruise control, active lane keeping, side-view assist, and lane departure warning systems following real-world use. METHODS: Fifty-four Insurance Institute for Highway Safety employees participated and drove a 2016 Toyota Prius, 2016 Honda Civic, 2017 Audi Q7, or 2016 Infiniti QX60 for up to several weeks...
March 1, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28327512/prevalence-and-determinants-of-suboptimal-vitamin-d-levels-in-a-multiethnic-asian-population
#3
Ryan Eyn Kidd Man, Ling-Jun Li, Ching-Yu Cheng, Tien Yin Wong, Ecosse Lamoureux, Charumathi Sabanayagam
This population-based cross-sectional study examined the prevalence and risk factors of suboptimal vitamin D levels (assessed using circulating 25-hydroxycholecalciferol (25(OH)D)) in a multi-ethnic sample of Asian adults. Plasma 25(OH)D concentration of 1139 Chinese, Malay and Indians (40-80 years) were stratified into normal (≥30 ng/mL), and suboptimal (including insufficiency and deficiency, <30 ng/mL) based on the 2011 Endocrine Society Clinical Practice Guidelines. Logistic regression models were used to assess the associations of demographic, lifestyle and clinical risk factors with the outcome...
March 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28320379/mirnas-associated-with-prostate-cancer-risk-and-progression
#4
REVIEW
Hung N Luu, Hui-Yi Lin, Karina Dalsgaard Sørensen, Olorunseun O Ogunwobi, Nagi Kumar, Ganna Chornokur, Catherine Phelan, Dominique Jones, LaCreis Kidd, Jyotsna Batra, Kosj Yamoah, Anders Berglund, Robert J Rounbehler, Mihi Yang, Sang Haak Lee, Nahyeon Kang, Seung Joon Kim, Jong Y Park, Giuliano Di Pietro
Prostate cancer is the most common malignancy among men in the US. Though considerable improvement in the diagnosis of prostate cancer has been achieved in the past decade, predicting disease outcome remains a major clinical challenge. Recent expression profiling studies in prostate cancer suggest microRNAs (miRNAs) may serve as potential biomarkers for prostate cancer risk and disease progression. miRNAs comprise a large family of about 22-nucleotide-long non-protein coding RNAs, regulate gene expression post-transcriptionally and participate in the regulation of numerous cellular processes...
March 20, 2017: BMC Urology
https://www.readbyqxmd.com/read/28317619/membranoproliferative-glomerulonephritis-in-pregnancy
#5
Devika Nair, Laura Kidd, N Kevin Krane
BACKGROUND: Membranoproliferative glomerulonephritis (MPGN) is an uncommon form of glomerulonephritis and it can be particularly difficult to predict outcomes and manage women with this disorder during pregnancy. MATERIALS AND METHODS: The management of 3 successful pregnancies in women with MPGN from 1 center and previously described cases from the world literature are reviewed. This includes a number of large studies of pregnancy in women with underlying glomerular disease as well as small case series and individual reports...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28303075/epistemic-injustice-and-illness
#6
Ian James Kidd, Havi Carel
This article analyses the phenomenon of epistemic injustice within contemporary healthcare. We begin by detailing the persistent complaints patients make about their testimonial frustration and hermeneutical marginalization, and the negative impact this has on their care. We offer an epistemic analysis of this problem using Miranda Fricker's account of epistemic injustice. We detail two types of epistemic injustice, testimonial and hermeneutical, and identify the negative stereotypes and structural features of modern healthcare practices that generate them...
February 2017: Journal of Applied Philosophy
https://www.readbyqxmd.com/read/28301670/mns-duffy-and-kell-blood-groups-among-the-uygur-population-of-xinjiang-china
#7
G Y Lin, X L Du, J J Shan, Y N Zhang, Y Q Zhang, Q H Wang
Human blood groups are a significant resource for patients, leading to a fierce international competition in the screening of rare blood groups. Some rare blood group screening programs have been implemented in western countries and Japan, but not particularly in China. Recently, the genetic background of ABO and Rh blood groups for different ethnic groups or regions in China has been focused on increasingly. However, rare blood groups such as MN, Duffy, Kidd, MNS, and Diego are largely unexplored. No systematic reports exist concerning the polymorphisms and allele frequencies of rare blood groups in China's ethnic minorities such as Uygur and Kazak populations of Xinjiang, unlike those on the Han population...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28293026/therapy-the-role-of-liquid-biopsies-to-manage-and-predict-prrt-for-nets
#8
Mark Kidd, Irvin M Modlin
No abstract text is available yet for this article.
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28284753/effects-of-nebulised-magnesium-sulphate-on-inflammation-and-function-of-the-guinea-pig-airway
#9
Dawn L Turner, William R Ford, Emma J Kidd, Kenneth J Broadley, Colin Powell
Magnesium sulphate is a potential treatment for acute severe asthma. However, the mechanisms and dose-response relationships are poorly understood. The first objective of this study was to examine whether inhaled magnesium sulphate exerts bronchodilator activity measured as bronchoprotection against histamine-induced bronchoconstriction in conscious guinea-pigs alone and combined with salbutamol. Secondly, we examined whether inhaled magnesium sulphate inhibits airways inflammation and function in models of neutrophilic and eosinophilic lung inflammation induced, respectively, by inhaled lipopolysaccharide or the inhaled antigen, ovalbumin (OVA)...
March 8, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28284384/autosomal-dominant-tubulointerstitial-kidney-disease
#10
REVIEW
Anthony J Bleyer, Kendrah Kidd, Martina Živná, Stanislav Kmoch
There are 3 major forms of autosomal dominant tubulointerstitial kidney disease (ADTKD): ADTKD due to UMOD mutations, MUC1 mutations, and mutations in the REN gene encoding renin. Lack of knowledge about these conditions contributes to frequent nondiagnosis, but with even limited knowledge, nephrologists can easily obtain a diagnosis and improve patient care. There are 3 cardinal features of these disorders: (1) the conditions are inherited in an autosomal dominant manner and should be considered whenever both a parent and child suffer from kidney disease; the presence of even more affected family members provides further support...
March 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28283819/neurological-complications-of-beh%C3%A3-et-s-syndrome
#11
D P Kidd
In this review of the neurological complications of Behçet's syndrome, the clinical features and epidemiology of the systemic disease are summarised before a discussion of the neurological syndromes which may develop is made. Neurological involvement occurs in 9% of cases, and is equally prevalent in each geographical area. Vascular complications occur in 14%, in whom thrombosis of the venous sinuses or cerebral veins occurs, and intracranial hypertension, venous infarction and parenchymal haemorrhage may develop...
March 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28279406/preprocedure-evaluation-of-a-dysfunctional-dialysis-access
#12
Keith B Quencer, Jason Kidd, Thomas Kinney
Given the many different types of hemodialysis access and the various problems that can occur in each, a structured approach should be taken in the preprocedure evaluation of patients referred for hemodialysis access intervention. Abnormalities detected on surveillance or monitoring trigger referrals for evaluation and intervention in hopes of preventing thrombosis or underdialysis. Familiarity with surveillance and monitoring findings not only facilitates better communication with nephrologists but also helps the interventionalist surmise where the site of stenosis might be and which stenoses are clinically relevant...
March 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/28279308/detection-of-somatic-variants-in-peripheral-blood-lymphocytes-using-a-next-generation-sequencing-multigene-pan-cancer-panel
#13
Bradford Coffee, Hannah C Cox, John Kidd, Scott Sizemore, Krystal Brown, Susan Manley, Debora Mancini-DiNardo
Next Generation Sequencing (NGS) multigene panels, which are routinely used to assess hereditary cancer risk, can detect both inherited germline variants and somatic variants in cancer-risk genes. We evaluated the frequency and distribution of likely somatic Pathogenic and Likely Pathogenic variants (PVs) detected in >220,000 individuals who underwent clinical testing with a 25-gene panel between September 2013 and March 2016. Likely somatic PVs are defined as variants with NGS read frequencies from 10% to 30%...
February 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28273168/within-host-whole-genome-analysis-of-an-antibiotic-resistant-pseudomonas-aeruginosa-strain-sub-type-in-cystic-fibrosis
#14
Laura J Sherrard, Anna S Tai, Bryan A Wee, Kay A Ramsay, Timothy J Kidd, Nouri L Ben Zakour, David M Whiley, Scott A Beatson, Scott C Bell
A Pseudomonas aeruginosa AUST-02 strain sub-type (M3L7) has been identified in Australia, infects the lungs of some people with cystic fibrosis and is associated with antibiotic resistance. Multiple clonal lineages may emerge during treatment with mutations in chromosomally encoded antibiotic resistance genes commonly observed. Here we describe the within-host diversity and antibiotic resistance of M3L7 during and after antibiotic treatment of an acute pulmonary exacerbation using whole genome sequencing and show both variation and shared mutations in important genes...
2017: PloS One
https://www.readbyqxmd.com/read/28272534/genetics-of-the-peloponnesean-populations-and-the-theory-of-extinction-of-the-medieval-peloponnesean-greeks
#15
George Stamatoyannopoulos, Aritra Bose, Athanasios Teodosiadis, Fotis Tsetsos, Anna Plantinga, Nikoletta Psatha, Nikos Zogas, Evangelia Yannaki, Pierre Zalloua, Kenneth K Kidd, Brian L Browning, John Stamatoyannopoulos, Peristera Paschou, Petros Drineas
Peloponnese has been one of the cradles of the Classical European civilization and an important contributor to the ancient European history. It has also been the subject of a controversy about the ancestry of its population. In a theory hotly debated by scholars for over 170 years, the German historian Jacob Philipp Fallmerayer proposed that the medieval Peloponneseans were totally extinguished by Slavic and Avar invaders and replaced by Slavic settlers during the 6th century CE. Here we use 2.5 million single-nucleotide polymorphisms to investigate the genetic structure of Peloponnesean populations in a sample of 241 individuals originating from all districts of the peninsula and to examine predictions of the theory of replacement of the medieval Peloponneseans by Slavs...
March 8, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28260586/molecular-epidemiology-of-pseudomonas-aeruginosa-bloodstream-infection-isolates-in-a-non-outbreak-setting
#16
Kate L McCarthy, Tim J Kidd, David L Paterson
PURPOSE: The molecular epidemiology of Pseudomonas aeruginosa bloodstream infection (BSI) isolates has received limited attention. This study aims to characterize the molecular relationship of P. aeruginosa BSI isolates in the non-outbreak setting at a single tertiary healthcare facility. METHODOLOGY:   P. aeruginosa BSI isolates from patients who were admitted to the Royal Brisbane and Women's Hospital over a 13 month period from November 2009 were identified retrospectively from the Pathology Queensland Clinical and Scientific Information System...
March 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28258231/antibiotic-tolerance-and-the-alternative-lifestyles-of-staphylococcus-aureus
#17
REVIEW
Long M G Bui, Brian P Conlon, Stephen P Kidd
Staphylococcus aureus has an incredible ability to survive, either by adapting to environmental conditions or defending against exogenous stress. Although there are certainly important genetic traits, in part this ability is provided by the breadth of modes of growth S. aureus can adopt. It has been proposed that while within their host, S. aureus survives host-generated and therapeutic antimicrobial stress via alternative lifestyles: a persister sub-population, through biofilm growth on host tissue or by growing as small colony variants (SCVs)...
February 28, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/28253016/fragmented-inclusion-community-participation-and-lesbian-gay-bisexual-trans-and-queer-people-with-diagnoses-of-schizophrenia-and-bipolar-disorder
#18
Merrick Pilling, Meg Howison, Tyler Frederick, Lori Ross, Chyrell D Bellamy, Larry Davidson, Kwame McKenzie, Sean A Kidd
Community participation is often cited as a crucial component of wellness for people with mental health diagnoses. Few studies explore community participation from the perspective of lesbian, gay, bisexual, trans, and queer (LGBTQ) people with diagnoses of schizophrenia and bipolar disorder. This article describes an in-depth qualitative study with 16 LGBTQ people; 18 social service workers; and 2 key informants in Toronto, Ontario that examined access to communities for LGBTQ people with mental health diagnoses...
March 2, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28252377/understanding-perceptions-of-community-participation-in-persons-with-severe-mental-illness-a-mixed-methods-approach
#19
Angela K Day, Rajiv Lalla, Tyler Frederick, Lesley A Tarasoff, Gursharan Virdee, Kwame McKenzie, William Zahn, Sean A Kidd
OBJECTIVES: This study aims to measure community participation in persons with severe mental illness (SMI) in Toronto, Ontario and outlines a methodological approach for understanding the dimensions of community participation. METHODS: A mixed methods approach was used to define activity spaces through participatory mapping and a qualitative survey interview for participants (N = 31), selected through a stratified purposeful sampling strategy. Five neighbourhoods in Toronto were sampled in an attempt to obtain an ethnically diverse sample...
March 1, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28249093/exploring-use-of-the-coordinate-response-measure-in-a-multitalker-babble-paradigm
#20
Larry E Humes, Gary R Kidd, Daniel Fogerty
Purpose: Three experiments examined the use of competing coordinate response measure (CRM) sentences as a multitalker babble. Method: In Experiment I, young adults with normal hearing listened to a CRM target sentence in the presence of 2, 4, or 6 competing CRM sentences with synchronous or asynchronous onsets. In Experiment II, the condition with 6 competing sentences was explored further. Three stimulus conditions (6 talkers saying same sentence, 1 talker producing 6 different sentences, and 6 talkers each saying a different sentence) were evaluated with different methods of presentation...
March 1, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
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