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Respiration AND preterm

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https://www.readbyqxmd.com/read/29701312/tidal-breath-eno-measurements-in-a-cohort-of-unsedated-hospitalized-neonates-a-method-validation
#1
Birgitte J Schmidt, Pauline S Reim, Andreas K Jensen, Per Albertsen, Gorm Greisen, Inger M Jørgensen
AIM: Exhaled Nitric oxide (eNO) is an inflammatory marker. In 2002 Hall et al. [J Appl Physiol. 92:59-66] established an infant eNO measurement method, fulfilling four criteria of feasibility: simple, non-invasive, without impact on the natural breathing pattern, and accounting for flow by NO output (V'NO). Although tidal breathing is accepted as an eNO measurement method in uncooperative patients, it is seldom used outside research labs. The variability and lack of validated methods have restrained from exploring the area in preterm and term neonates the last years...
April 27, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29628967/augmentation-of-respiratory-muscle-activities-in-preterm-infants-with-feeding-desaturation
#2
Dong Rak Kwon, Gi Young Park, Ji Eun Jeong, Woo Taek Kim, Eun Joo Lee
Purpose: Frequent desaturation due to immature incoordination of suck-swallow-breathing in preterm infants can influence multiple organs such as the heart, lungs, and brain, which can then affect growth and development. Most notably in preterm infants, feeding desaturation may even affect pulmonary function during gavage feeding. Because respiratory muscle activities may reflect the work required during respiration, we evaluated the differences in these activities between full-term and preterm infants with feeding desaturation, and investigated the correlations with clinical variables...
March 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29447932/determining-the-venous-oxygen-reservoir-a-novel-hypothetical-approach-to-titration-of-supplemental-oxygen-in-preterm-newborns
#3
Chad C Andersen, Nicolette A Hodyl, Nina M Ziegler, Michael J Stark
While normal oxygen saturation is commonly thought to be a marker of normal oxygenation, cutaneous saturation does not account for the sufficiency of oxygen within each cell or that of the system overall. Rather, cutaneous oximetry simply defines the saturation of haemoglobin (Hb) with oxygen in a pulsatile vessel. Assessment of sufficiency is best determined by measurement of the amount of oxygen left over following aerobic respiration. This left over oxygen is 'stored' on Hb in the venous compartment and can be calculated as the venous oxygen content...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29390342/the-predictive-value-of-early-oral-motor-assessments-for-neurodevelopmental-outcomes-of-moderately-and-late-preterm-infants
#4
Xianhong Zhang, Mei Zhou, Huaying Yin, Ying Dai, Yuwei Li
Oral motor assessment is used to identify abnormal sucking patterns which may reflect neurodevelopmental problems in preterm infants, but few studies have focused on moderately and late preterm infants. We enrolled 118 moderately and late preterm infants (mean gestational age, 35.04 weeks; mean birth weight, 2347.59 g) and analyzed the relationship between the Neonatal Oral-Motor Assessment Scale scores of these infants and the Chinese revision of Bayley Scales of Infant Development outcomes at 6 months corrected age...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29345197/neonatal-hyperoxia-depletes-pulmonary-vein-cardiomyocytes-in-adult-mice-via-mitochondrial-oxidation
#5
Min Yee, Ethan David Cohen, William Domm, George A Porter, Andrew N McDavid, Michael A O'Reilly
Supplemental oxygen given to preterm infants has been associated with permanently altering postnatal lung development. Now that these individuals are reaching adulthood, there is growing concern that early-life oxygen exposure may also promote cardiovascular disease through poorly understood mechanisms. We previously reported that adult mice exposed to 100% oxygen between postnatal days 0-4 develop pulmonary hypertension defined pathologically by capillary rarefaction, dilation of arterioles and veins, cardiac failure, and a reduced lifespan...
January 18, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29206066/magnesium-induces-preconditioning-of-the-neonatal-brain-via-profound-mitochondrial-protection
#6
Gabriella Koning, Anna-Lena Leverin, Syam Nair, Leslie Schwendimann, Joakim Ek, Ylva Carlsson, Pierre Gressens, Claire Thornton, Xiaoyang Wang, Carina Mallard, Henrik Hagberg
Magnesium sulphate (MgSO4 ) given to women in preterm labor reduces cerebral palsy in their offspring but the mechanism behind this protection is unclear, limiting its effective, safe clinical implementation. Previous studies suggest that MgSO4 is not neuroprotective if administered during or after the insult, so we hypothesised that MgSO4 induces preconditioning in the immature brain. Therefore, we administered MgSO4 at various time-points before/after unilateral hypoxia-ischemia (HI) in seven-day-old rats...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29190622/classifying-apnea-of-prematurity-by-transcutaneous-electromyography-of-the-diaphragm
#7
Juliette V Kraaijenga, Gerard J Hutten, Cornelia G de Waal, Frans H de Jongh, Wes Onland, Anton H van Kaam
BACKGROUND: Treatment of apnea is highly dependent on the type of apnea. Chest impedance (CI) has inaccuracies in monitoring respiration, which compromises accurate apnea classification. Electrical activity of the diaphragm measured by transcutaneous electromyography (EMG) is feasible in preterm infants and might improve the accuracy of apnea classification. OBJECTIVES: To compare the accuracy of apnea classification based on diaphragmatic EMG (dEMG) and CI tracings in preterm infants...
2018: Neonatology
https://www.readbyqxmd.com/read/29099422/short-article-the-endoscopic-and-histologic-findings-of-infants-who-have-experienced-brief-resolved-unexplained-events
#8
Chaowapong Jarasvaraparn, Maria B R Gallegos, Madhuri S Mulekar, Bin Wang, David A Gremse, Karen D Crissinger
INTRODUCTION: A brief resolved unexplained event (BRUE) describes an event associated with a change in muscle tone, color, respiration, and responsiveness that is unexplained after an appropriate examination. Some infants with higher risk BRUE may undergo endoscopy as part of their evaluation. OBJECTIVE: This retrospective study aimed to identify the endoscopic findings in infants who have experienced a higher risk BRUE. We also compared the characteristics, prenatal, natal, and postnatal risk factors between 23 infants who underwent endoscopic evaluation and 23 race-matched/sex-matched/term-matched/preterm-matched infants who did not undergo endoscopic evaluation...
February 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29073688/-does-a-higher-ambient-temperature-in-the-delivery-room-prevent-hypothermia-in-preterm-infants-1500%C3%A2-g
#9
Janaina Kristina Isabel Johannsen, Matthias Vochem, Patrick Neuberger
Aim Because hypothermia in the preterm infant immediately after delivery can cause an increase in morbidity and mortality in the newborn period, one of the most important goals is preventing hypothermia in preterm infants. There is sufficient data on prevention methods such as warming respirator gas, radiant heat sources, warmed blankets, sterile polyethylene bags, etc. However no general recommendation of the optimal environmental temperature in the delivery room exists. Methods We compared the rectal body temperature of VLBW infants on admission to the NICU, born in delivery rooms with an ambient temperature of 28°C vs...
October 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/29064171/breath-detection-by-transcutaneous-electromyography-of-the-diaphragm-and-the-graseby-capsule-in-preterm-infants
#10
Cornelia G de Waal, Juliette V Kraaijenga, Gerard J Hutten, Frans H de Jongh, Anton H van Kaam
OBJECTIVE: To compare triggering, breath detection and delay time of the Graseby capsule (GC) and transcutaneous electromyography of the diaphragm (dEMG) in spontaneous breathing preterm infants. METHODS: In this observational study, a 30 minutes respiration measurement was conducted by respiratory inductance plethysmography (RIP), the GC, and dEMG in stable preterm infants. Triggering was investigated with an in vitro set-up using the Infant Flow(®) SiPAP(TM) system...
December 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29055243/physiological-vital-sign-ranges-in-newborns-from-34-weeks-gestation-a-systematic-review
#11
REVIEW
Michelle Paliwoda, Karen New, Mark Davies, Fiona Bogossian
CONTEXT: The birth process and the moments thereafter are a crucial time for newborns as they adapt to extra uterine life. The adaptive process begins immediately and can take a number of days to complete. The process involves initiating and maintaining respirations, thermoregulation, and the change from foetal circulation to newborn circulation. The majority of newborns successfully adapt to extra uterine life, some experience difficulty. Early warning tools may assist clinicians identify early signs of failure to adapt and/or deterioration but these are dependent on 'Normal' vital sign reference ranges for triggering an escalation of care...
January 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29046872/swallow-breath-interaction-and-phase-of-respiration-with-swallow-during-non-nutritive-suck-in-infants-affected-by-neonatal-abstinence-syndrome
#12
Eric W Reynolds, Debbie Grider, Cynthia S Bell
BACKGROUND: The development of suck-swallow-breath rhythms during non-nutritive suck (NNS) may be an indicator of neurologic integrity. We have described swallow-breath (SwBr) interaction and phase of respiration (POR) with swallow during NNS in low-risk preterm (LRP) infants. NNS in infants with neonatal abstinence syndrome (NAS) has not been described with our method. METHOD: Suckle, swallow, thoracic motion, and nasal airflow were measured during NNS in 10 infants with NAS and 12 unaffected infants (control)...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28748430/inicu-integrated-neonatal-care-unit-capturing-neonatal-journey-in-an-intelligent-data-way
#13
Harpreet Singh, Gautam Yadav, Raghuram Mallaiah, Preetha Joshi, Vinay Joshi, Ravneet Kaur, Suneyna Bansal, Samir K Brahmachari
Neonatal period represents first 28 days of life, which is the most vulnerable time for a child's survival especially for the preterm babies. High neonatal mortality is a prominent and persistent problem across the globe. Non-availability of trained staff and infrastructure are the major recognized hurdles in the quality care of these neonates. Hourly progress growth charts and reports are still maintained manually by nurses along with continuous calculation of drug dosage and nutrition as per the changing weight of the baby...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28700565/nasal-continuous-positive-airway-pressure-influences-bottle-feeding-in-preterm-lambs
#14
Nathalie Samson, Audrey Michaud, Rahmeh Othman, Charlène Nadeau, Stéphanie Nault, Danny Cantin, Michaël Sage, Céline Catelin, Jean-Paul Praud
BackgroundIn preterm infants, the time from initiation to full oral feeding can take weeks, which represents a very worrisome problem in neonatal medicine. Although current knowledge suggests that oral feeding should be introduced early, this is often delayed due to the need for prolonged nasal continuous positive airway pressure (nCPAP). Indeed, most caregivers fear that nCPAP could disrupt sucking-swallowing-breathing coordination and induce tracheal aspiration. The goal of the present study was to assess the impact of nCPAP delivered by the Infant Flow System on the physiology of sucking-swallowing-breathing coordination during bottle-feeding in preterm lambs over 24 h...
December 2017: Pediatric Research
https://www.readbyqxmd.com/read/28654562/cardio-respiratory-events-and-inflammatory-response-after-primary-immunization-in-preterm-infants-32-weeks-gestational-age-a-randomized-controlled-study
#15
RANDOMIZED CONTROLLED TRIAL
Wissal Ben Jmaa, Alfredo I Hernández, Megan R Sutherland, Anik Cloutier, Nathalie Germain, Christian Lachance, Brigitte Martin, Marc H Lebel, Patrick Pladys, Anne Monique Nuyt
BACKGROUND: Inflammation may depress respiration in neonates. This study aimed to establish a link between postimmunization inflammation and cardio-respiratory events (CREs). METHODS: Randomized double-blind controlled study of infants born < 32 weeks gestation receiving the 2 months vaccine, which comprised diphtheria and tetanus toxoids and acellular pertussis adsorbed combined with inactivated poliomyelitis vaccines and Haemophilus b conjugate and the pneumococcal conjugate 10-valent vaccines...
October 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28609542/effect-of-single-use-laser-cut-slow-flow-nipples-on-respiration-and-milk-ingestion-in-preterm-infants
#16
Katlyn E McGrattan, David H McFarland, Jesse C Dean, Elizabeth Hill, David R White, Bonnie Martin-Harris
Purpose: Single-use, laser-cut, slow-flow nipples were evaluated for their effect on respiration and milk ingestion in 13 healthy preterm infants (32.7-37.1 weeks postmenstrual age) under nonlaboratory, clinical conditions. Method: The primary outcomes of minute ventilation and overall milk transfer were measured by using integrated nasal airflow and volume-calibrated bottles during suck bursts and suck burst breaks during slow-flow and standard-flow nipple bottle feedings...
August 15, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28600392/physical-stimulation-of-newborn-infants-in-the-delivery-room
#17
Vincent D Gaertner, Sophie A Flemmer, Laila Lorenz, Peter G Davis, C Omar Farouk Kamlin
OBJECTIVE: Neonatal resuscitation guidelines recommend that newborn infants are stimulated to assist with the establishment of regular respirations. The mode, site of application and frequency of stimulations are not stipulated in these guidelines. The effectiveness of stimulation in improving neonatal transition outcomes is poorly described. METHODS: We conducted a retrospective review of video recordings of neonatal resuscitation at a tertiary perinatal centre...
March 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28419371/sleep-a-window-into-autonomic-control-in-children-born-preterm-and-growth-restricted
#18
Stephanie R Yiallourou, Euan M Wallace, Christie Whatley, Alexsandria Odoi, Samantha Hollis, Aidan J Weichard, Jayan Shivanandhan Muthusamy, Suraj Varma, James Cameron, Om Narayan, Rosemary S C Horne
Study Objectives: Preterm birth and fetal growth restriction (FGR) are both associated with risk of hypertension in adulthood. Mechanisms leading to this pathology are unclear. In children aged 5-12 years, who were born preterm and FGR, we used sleep as a tool to assess autonomic control with assessment of cardiovascular structure and function. Methods: Eighteen children born preterm and FGR, 15 children born preterm with appropriate birth weights for gestational age (AGA), and 20 AGA term-born children were studied...
May 1, 2017: Sleep
https://www.readbyqxmd.com/read/28268474/improving-heart-rate-estimation-in-preterm-infants-with-bivariate-point-process-analysis-of-heart-rate-and-respiration
#19
Alan H Gee, Riccardo Barbieri, David Paydarfar, Premananda Indic
Accurate estimation of heart rate dynamics in preterm infants is important for predicting recurrent episodes of severe bradycardia. We hypothesize that estimation of heart rate can be improved by including respiration as a state variable, based on mechanisms that underlie cardio-respiratory coherence. For ten preterm infants, we demonstrate that including respiration as a covariate improves estimation accuracy by an average of 11% across bradycardia severity, and reduces the maximum error by 8%. We also find that cardio-respiratory coherence increases in low frequency content just prior to severe bradycardia...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226647/improving-heart-rate-estimation-in-preterm-infants-with-bivariate-point-process-analysis-of-heart-rate-and-respiration
#20
Alan H Gee, Riccardo Barbieri, David Paydarfar, Premananda Indic, Alan H Gee, Riccardo Barbieri, David Paydarfar, Premananda Indic, David Paydarfar, Riccardo Barbieri, Alan H Gee, Premananda Indic
Accurate estimation of heart rate dynamics in preterm infants is important for predicting recurrent episodes of severe bradycardia. We hypothesize that estimation of heart rate can be improved by including respiration as a state variable, based on mechanisms that underlie cardio-respiratory coherence. For ten preterm infants, we demonstrate that including respiration as a covariate improves estimation accuracy by an average of 11% across bradycardia severity, and reduces the maximum error by 8%. We also find that cardio-respiratory coherence increases in low frequency content just prior to severe bradycardia...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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