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Respiratory AND newborn

Y Hodovanets, A Babintseva, L Agafonova, O Makarova, A Frunza
Newborns are especially prone to oxidative stress (OS). Many free radical-mediated diseases have been described in newborns including bronchopulmonary dysplasia, respiratory distress syndrome, encephalopathy, and kidney injury. Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns. 67 critically sick full-term neonates were enrolled in the study including 31 newborns with AKI (group I) and 36 newborns without AKI (group II)...
May 2018: Georgian Medical News
Hiroyuki Tsuda, Tomomi Kotani, Tomoko Nakano, Kenji Imai, Takafumi Ushida, Akihiro Hirakawa, Fumie Kinoshita, Yuichiro Takahashi, Shigenori Iwagaki, Fumitaka Kikkawa
BACKGROUND: Whether or not the period of fetal lung maturity differs between twin and singleton pregnancies has not been clarified. We examined whether or not fetal lung maturity and fetal lung absorption are achieved earlier in twin fetuses than in singleton fetuses. METHODS: We registered 454 singleton pregnancies and 398 twin pregnancies with no congenital abnormalities affecting the respiratory function or neonatal deaths. All patients were delivered by Caesarean section without labor between 24 and 38 gestational weeks...
June 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Serena de Gelidi, Nima Seifnaraghi, Andy Bardill, Andrew Tizzard, Yu Wu, Erich Sorantin, Sven Nordebo, Andreas Demosthenous, Richard H Bayford
Newborns with lung immaturity often require continuous monitoring and treatment of their lung ventilation in intensive care units, especially if born preterm. Recent studies indicate that Electrical Impedance Tomography (EIT) is feasible in newborn
 infants and children, and can quantitatively identify changes in regional lung aeration and ventilation following alterations to respiratory conditions. Information on the patient-specic shape of the torso and its role in minimizing the artefacts in the
 reconstructed images can improve the accuracy of the clinical parameters obtained from EIT...
June 12, 2018: Physiological Measurement
Ruchi Amin, Marjorie J Arca
BACKGROUND: The use of neurally adjusted ventilator assist (NAVA) in congenital diaphragmatic hernia (CDH) patients has been historically deemed unwise, since the trigger for breaths is the electromyographic activity of the diaphragmatic muscle. We report on our NAVA experience in CDH patients. METHODS: We performed an IRB-approved retrospective review of newborns from 1/1/2012-1/1/2017 at a Level I Children's Surgery Center undergoing CDH repair. Data obtained included demographics, defect type and repair, respiratory support, and outcomes...
May 19, 2018: Journal of Pediatric Surgery
André Moraes Freitas, Ricardo Mörschbächer, Mariana R Thorell, Ernani Luis Rhoden
Background and objectives: Advances in neonatal care promoted increased survival rates of preterm infants, with a consequent increase in the number of children affected by retinopathy of prematurity (ROP). This study estimates the incidence of ROP and evaluates potential risk factors associated. Methods: A retrospective cohort study of preterm infants born in a tertiary neonatal intensive care unit was conducted from March 2005 to August 2015. Six hundred and thirty-nine newborns were included based on the following criteria: infants born with less than 32 weeks' gestation or birth weight below 1500 g; or neonates born with 32-37 weeks' gestation or birth weight above 1500 g and any of the following associated: multiple gestation, respiratory distress syndrome, sepsis, blood transfusions or intraventricular hemorrhage...
2018: International Journal of Retina and Vitreous
Kamalesh K Gulia, Velayudhan Mohan Kumar
In contrast to newborns, who spend 16-20 h in sleep each day, adults need only about sleep daily. However, many elderly may struggle to obtain those 8 h in one block. In addition to changes in sleep duration, sleep patterns change as age progresses. Like the physical changes that occur during old age, an alteration in sleep pattern is also a part of the normal ageing process. As people age, they tend to have a harder time falling asleep and more trouble staying asleep. Older people spend more time in the lighter stages of sleep than in deep sleep...
May 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Sara A Taleb, Asmaa A Al Thani, Khalid Al Ansari, Hadi M Yassine
Respiratory syncytial virus continues to pose a serious threat to the pediatric populations worldwide. With a genomic makeup of 15,200 nucleotides, the virus encodes for 11 proteins serving as envelope spikes, inner envelope proteins, and non-structural and ribonucleocapsid complexes. The fusion (F) and attachment (G) surface glycoproteins are the key targets for neutralizing antibodies. The highly variable G with altered glycosylations and the conformational alternations of F create challenges for vaccine development...
June 6, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Othmane Alaoui
We report the case of a newborn male admitted on the first day of his life with temporo-occipital swelling detected at birth. Clinical examination showed conscious, hemodynamically and respiratory stable, afebrile, vigorous and responsive newborn; craniofacial examination objectified soft, mobile, temporo-occipital mass covered by the scalp measuring 10 cm along its longer left paramedian axis (A). Craniocerebral CT scan showed large heterogeneous left subgaleal parietal-temporal-occipital mass measuring 40/80 mm, suggesting a tumor of soft tissue components of the scalp (B)...
2018: Pan African Medical Journal
Alessandro Perri, Riccardo Riccardi, Rossella Iannotta, Domenico V Di Molfetta, Roberta Arena, Giovanni Vento, Enrico Zecca
OBJECTIVES: We aim to verify the diagnostic accuracy of a lung ultrasonography (LUS) score to early predict the need for surfactant therapy in newborns with respiratory distress syndrome (RDS), and to compare it with a chest X-ray score. METHODS: In this prospective diagnostic accuracy study we included all newborns admitted for respiratory distress and initially treated with nasal CPAP. LUS was performed within 2 h from nasal CPAP positioning and in any case before surfactant administration...
June 5, 2018: Pediatric Pulmonology
Mihir R Atreya, John M Lorenz, Vivek Narendran
BACKGROUND: Bubble continuous positive airway pressure (bCPAP) is a simple, safe, and cost-effective strategy to provide respiratory support to newborns with respiratory distress syndrome in resource-limited settings. PURPOSE: To understand whether implementation of bCPAP, relative to other modes of respiratory support in the care of newborns with respiratory distress syndrome, increases positive attitudes about its potential for consistent and widespread use among providers in neonatal intensive care units (NICUs) of lower middle-income countries...
May 31, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Fabiola Castorena-Torres, Mario René Alcorta-García, Víctor Javier Lara-Díaz
Both transient tachypnea of the newborn and neonatal respiratory distress syndrome have been associated with changes in gene expression of aquaporine-5 (AQP5) and the β subunit of the epithelial sodium channel (β-ENaC) in the respiratory epithelium. Gastric aspirate (GA) obtained immediately after birth could represent a new source for gene expression analysis for these respiratory diseases. The aims of this study were to determine the feasibility of estimating AQP5 and β-ENaC gene expression in exfoliated respiratory epithelial cells from the GA of term neonates, and to compare the values with those found in scraped nasal epithelial cells, previously validated as a surrogate for distal lung epithelium in terms of ionic channel activity...
April 2018: Heliyon
Angelo Nicolosi, Laura Cardoit, Pierrick Pasquereau, Christèle Jaillet, Muriel Thoby-Brisson, Laurent Juvin, Didier Morin
Due to their extremely small size that gives them unique physicochemical properties, nanoparticles (NPs) are used in the production of everyday materials. However, NPs can accumulate in body organs and could cause various diseases. Moreover, NPs that cross biological membranes such as the blood-brain barrier can aggregate in the brain and potentially produce neuronal damage. Although studies have reported the effects of diverse NPs on the bioelectrical properties of individual neurons, their potential influences on the operation of whole neuronal networks have not been documented...
May 31, 2018: Neurotoxicology
Emily M Siebers, Melinda J Choi, Jennifer A Tinklenberg, Margaret J Beatka, Samuel Ayres, Hui Meng, Daniel C Helbling, Akiko Takizawa, Brian Bennett, Alexander M Garces, Luiz-Gabriel Dias Duarte Machado, David Dimmock, Melinda R Dwinell, Aron M Geurts, Michael W Lawlor
Mitochondrial diseases (MDs) result from alteration of the mitochondrial respiratory chain (MRC) function. Despite the prevalence of MDs in the population, the paucity of animal models available limits the understanding of these disorders. Mutations in SDHA, a gene that codes for the alpha subunit of succinate dehydrogenase (SDH), can cause some forms of MD. SDHA is a crucial contributor to MRC function. In order to expand the range of MD animal models available, we attempted to generate a Sdha knockout rat...
May 8, 2018: Journal of Neuropathology and Experimental Neurology
Clarissa Gutiérrez Carvalho, Renato Soibelmann Procianoy, Eurico Camargo Neto, Rita C Silveira
Ventilator-induced lung injury is well recognized, and appropriate arterial saturation target is unknown, so gentle modes of ventilation and minimizing oxidative stress have been well studied. Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1 β , IL-10, and IL-8 and TNF- α in preterm newborns under mechanical ventilation (MV) in their first two days. Methods . Prospective cohort including neonates with severe respiratory distress...
2018: Journal of Immunology Research
Min Yang, Xiao-Bo Fan, Jiang-Nan Wu, Ji-Mei Wang
Assisted reproductive technology (ART) has been widely used among women with infertility. However, the association of ART with birth defects and stillbirth remains controversial and has rarely been reported in China. A retrospective cohort study of 112,043 pregnant women and 114,522 newborns from 2006 to 2016 was performed. Compared to spontaneously conceived infants, ART-conceived infants had a higher likelihood of any birth defect, with an adjusted odds ratio (OR) of 2.10 (95% confidence interval, 1.63-2...
May 29, 2018: Scientific Reports
T Arun Babu, Y Soliman, K Mohammad
Persistent pulmonary hypertension of newborn (PPHN) is a very rare manifestation of congenital cytomegalovirus (CMV) infection. PPHN associated with CMV can be severe but is usually transient and responds well to antiviral therapy. We report a rare case of PPHN that occurred in the setting of fulminant congenital CMV infection and successful treatment with antiviral therapy along with review of the very few cases reported in literature. A male appropriate for gestational Age (AGA) newborn developed rapidly progressive respiratory distress starting at 11 hours of life requiring ventilatory support and 100% oxygen...
May 23, 2018: Journal of Neonatal-perinatal Medicine
Hsin-Hang Chen, Mei-Hua Hsu, Tsu-Lan Wu, Hsin-Chieh Li, Chyi-Liang Chen, Rajendra Prasad Janapatla, Lin-Hui Su, Cheng-Hsun Chiu
BACKGROUND: Streptococcus pneumoniae is one of the most common pathogens to cause mucosal and invasive infection in humans. Most of the infection could be prevented through immunization by vaccines containing capsular polysaccharides but some infection may be caused by unencapsulated strains. METHODS: Clinical isolates of S.pneumoniae from January 2012 to December 2015 at Chang Gung Memorial Hospital, Taiwan. Serotyping by PCR method was performed. Clinical and laboratory information of patients infected by non-typeable pneumococci (NTP) were collected and analyzed...
May 14, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Alan T N Tita, Kathleen A Jablonski, Jennifer L Bailit, William A Grobman, Ronald J Wapner, Uma M Reddy, Michael W Varner, John M Thorp, Kenneth J Leveno, Steve N Caritis, Jay D Iams, George Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa
BACKGROUND: Studies of early term birth after demonstrated fetal lung maturity show that respiratory and other outcomes are worse with early term birth (370 -386 ) even after demonstrated fetal lung maturity when compared with full term birth (390 -406 ). However these studies included medically indicated births and are therefore potentially limited by confounding by the indication for delivery. Thus the increase in adverse outcomes might be due to the indication for early term birth rather than the early term birth itself...
May 22, 2018: American Journal of Obstetrics and Gynecology
Anna Maria Hibbs, Kristie Ross, Leigh Ann Kerns, Carol Wagner, Mamta Fuloria, Sharon Groh-Wargo, Teresa Zimmerman, Nori Minich, Curtis Tatsuoka
Importance: Black infants born preterm face high rates of recurrent wheezing throughout infancy. Vitamin D supplementation has the potential to positively or negatively affect wheezing through modulation of the pulmonary and immune systems. Objective: To assess the effectiveness of 2 vitamin D dosing strategies in preventing recurrent wheezing. Design, Setting, and Participants: A randomized clinical trial enrolled 300 black infants born at 28 to 36 weeks' gestation between January 2013 and January 2016 at 4 sites in the United States, and followed them up through March 2017...
May 22, 2018: JAMA: the Journal of the American Medical Association
Madeleine C Murphy, Christian Heiring, Nicoletta Doglioni, Daniele Trevisanuto, Mats Blennow, Kajsa Bohlin, Gianluca Lista, Ilaria Stucchi, Colm P F O'Donnell
Importance: Treatment options for a symptomatic pneumothorax in newborns include needle aspiration (NA) and chest drain (CD) insertion. There is little consensus as to the preferred treatment, reflecting a lack of evidence from clinical trials. Objective: To investigate whether treating pneumothoraces diagnosed on chest radiography (CR) in newborns receiving respiratory support with NA results in fewer infants having CDs inserted within 6 hours of diagnosis. Design, Setting, and Participants: This randomized clinical trial was conducted from October 7, 2013, to December 21, 2016...
May 14, 2018: JAMA Pediatrics
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