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https://www.readbyqxmd.com/read/28633556/oxidative-stress-and-dna-damage-in-newborns-born-to-mothers-with-hyperglycemia-%C3%A2-a-prospective-cohort-study
#1
K Dulasi Durga, B Adhisivam, G Vidya, B Vishnu Bhat, Bobby Zachariahc, Chand Parkashd
BACKGROUND: Hyperglycemic mothers have increased oxidative stress during pregnancy which can adversely affect the outcome in their neonates Objectives: To measure the oxidative stress and DNA damage in newborns born to mothers with hyperglycemia and correlate their immediate outcome with the amount of oxidative stress and DNA damage. METHODS: This prospective cohort study conducted in a tertiary care teaching hospital, south India included 3 groups - newborns born to pregestational diabetic mothers (PGDM), gestational diabetic mothers (GDM) and euglycemic mothers with 24 newborns in each...
June 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28629514/erythropoietin-mediated-regulation-of-central-respiratory-command
#2
Tommy Seaborn, Céline Caravagna
Erythropoietin (Epo) is a cytokine expressed throughout the body, including in the central nervous system where it can act as a breathing modulator in the central respiratory network. In vitro, Epo allows maintaining the activity of respiratory neurons during acute hypoxia, resulting in inhibition of the hypoxia-induced rhythm depression. In vivo, Epo action on the central respiratory command results in enhancement of the acute hypoxic ventilatory response, allowing a better oxygenation of the body by improvement of gases exchanges in the lungs...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28626595/williams-beuren-syndrome-and-congenital-lobar-emphysema-uncommon-association-with-common-pathology
#3
Timothy Andrew Walsh, Krishna Revanna Gopagondanahalli, Atul Malhotra
INTRODUCTION: Congenital lobar emphysema (CLE) and Williams-Beuren Syndrome are two rare conditions that have only been reported together in a single case study. CASE PRESENTATION: We report another case of a male Caucasian newborn with nonspecific initial respiratory distress, with detection of CLE on repeat chest X-ray on Day 25 of life and concurrent ventricular septal defect, supravalvular aortic stenosis, and branch pulmonary stenosis, in whom a 7q11.23 deletion consistent with Williams-Beuren Syndrome was made...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28626374/bochdalek-hernia-in-an-adult-with-upper-gastrointestinal-bleeding
#4
Mohammed Al-Dugdugi, Abdulhameed Alhazmi, Abdulhadi Khaliel, Luis Perez
Bochdalek hernia (BH) can be a life-threatening condition in infants. Approximately 85.3% of newborns with a BH are immediately at high risk and have a high mortality rate due to respiratory insufficiency [Kocakusak et al.: Hernia 2005;9: 284-287]. However, BH is almost asymptomatic in adults and discovered only incidentally [Wilkins et al.: Clin Imaging 1994;18: 224-229]. Complicated BH in adults might present with visceral incarceration and lethal complications. Upper gastrointestinal bleeding and acute pancreatitis are rarely reported in the literature as complications of BH in adults...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28624306/preclinical-assessment-of-safety-of-maternal-vaccination-against-respiratory-syncytial-virus-rsv-in-cotton-rats
#5
Jorge C G Blanco, Lioubov M Pletneva, Raymonde O Otoa, Mira C Patel, Stefanie N Vogel, Marina S Boukhvalova
Maternal immunization directed to control RSV infection in newborns and infants is an appealing vaccination strategy currently under development. In this work we have modeled maternal vaccination against RSV in cotton rats (CR) to answer two fundamental questions on maternal vaccine safety. We tested (i), whether a known, unsafe RSV vaccine (i.e., FI-RSV Lot 100 vaccine) induces vaccine enhanced disease in the presence of passively transferred, RSV maternal immunity, and (ii) whether the same FI-RSV vaccine could induce vaccine enhanced disease in CR litters when used to immunize their RSV-primed mothers...
June 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28621252/clinical-course-of-community-acquired-respiratory-syncytial-virus-pneumonia-in-newborns-hospitalized-in-neonatal-intensive-care-unit
#6
Selmin Karademir, Tamer Yoldaş
No abstract text is available yet for this article.
March 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28614426/incidental-finding-in-a-newborn-with-respiratory-distress
#7
Natália Noronha, Pedro Pires Epifânio, Patrícia Vaz Silva, António Pires, António Marinho, Eduardo Castela
No abstract text is available yet for this article.
June 12, 2017: Einstein
https://www.readbyqxmd.com/read/28612543/-the-improvement-in-the-primary-culture-of-alveolar-epithelial-type-of-rats
#8
Ling Jiang, Yuan-Dong Hu, Fei-Fei Xu, Ting-Hua Wang
OBJECTIVES: To improve the method of culturing and obtain purified alveolar epithelial type1 (AT1) cells of SD rats. METHODS: 1 d newborn SD rats were applied for cell culture and brains were decapitated for lung tissues obtaining after respiratory cessation. Collagenase1and DNase1 were used to digest and isolate cells. Then, cells were put into the plate coated with type1 rat tail collagen and different adherence was used to purify cells. Meanwhile, culture medium replacement was conducted after 48 h...
March 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28601952/an-in-vitro-experimental-model-for-analysis-of-central-control-of-sympathetic-nerve-activity
#9
Yuji Oyama, Kamon Iigaya, Yoshino Minoura, Toshitaka Okabe, Masahiko Izumizaki, Hiroshi Onimaru
Newborn rat brainstem-spinal cord preparations are useful for in vitro analysis of various brainstem functions including respiratory activity. When studying the central control of sympathetic nerve activity (SNA), it is important to record peripheral outputs of the SNA. We developed an in vitro preparation in which neuronal connections between the cardiovascular center in the medulla and SNA peripheral outputs are preserved. Zero- to 1-day-old rats were deeply anesthetized with isoflurane, and the brainstem and spinal cord were isolated with a partial right thoracic cage to record sympathetic nerve discharge from the right thoracic sympathetic nerve trunk (T9-T11)...
June 10, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28600701/the-impact-of-exposure-to-antidepressant-medications-during-pregnancy-on-neonatal-outcomes-a-review-of-retrospective-database-cohort-studies
#10
REVIEW
Casey R Tak, Kathleen M Job, Katie Schoen-Gentry, Sarah C Campbell, Patrick Carroll, Maged Costantine, Diana Brixner, Angela K Birnbaum, Catherine M T Sherwin
INTRODUCTION: Concerns with prescription antidepressant use in pregnant women have instigated the examination of potential associations between fetal exposure to antidepressant medication and outcomes including preterm delivery, congenital malformations, perinatal and post-natal adverse events, persistent pulmonary hypertension, and mortality. The retrospective cohort model is an often utilized study design. The objective of this review is to evaluate the literature on antidepressant use in pregnancy conducted as retrospective cohorts in national/regional medical, or claims databases that assess neonatal and infant outcomes for agreement between studies, ultimately providing a methodological and outcomes summary for future scientific endeavors...
June 9, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28598702/a-safe-and-efficient-bcg-vectored-vaccine-to-prevent-the-disease-caused-by-the-human-respiratory-syncytial-virus
#11
Emma Rey-Jurado, Jorge Soto, Nicolás Gálvez, Alexis M Kalergis
The human Respiratory Syncytial Virus (hRSV) causes lower respiratory tract infections including pneumonia and bronchiolitis. Such infections also cause a large number of hospitalizations and affects mainly newborns, young children and the elderly worldwide. Symptoms associated with hRSV infection are due to an exacerbated immune response characterized by low levels of IFN-γ, recruitment of neutrophils and eosinophils to the site of infection and lung damage. Although hRSV is a major health problem, no vaccines are currently available...
June 9, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28595292/neonatal-outcomes-associated-with-placental-abruption
#12
Katheryne L Downes, Edmond D Shenassa, Katherine L Grantz
Placental abruption, early separation of the placenta, is associated with preterm birth and perinatal mortality, but associations with other neonatal morbidities remains under-studied. We examined the association between abruption and newborn outcomes. We analyzed n = 223,341 singleton deliveries from the Consortium on Safe Labor Study, a retrospective, multi-site, observational study (2002-2008) of electronic medical records in the U.S. Adjusted relative risks (RR), incident ratio ratios and 99% confidence intervals (CI) were estimated...
June 8, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28593892/neonatal-hypoglycemia-risk-factors-and-outcomes
#13
Orhideja Stomnaroska, Elizabeta Petkovska, Snezana Jancevska, Dragan Danilovski
BACKGROUND AND AIMS: Severe neonatal hypoglycemia (HG) leads to neurologic damage, mental retardation, epilepsy, personality disorders, impaired cardiac performance and muscle weakness. We aimed to assess the clinical characteristics of children with hypoglycemia in a random population of newborns. PATIENTS, METHODS AND RESULTS: We investigated 84 patients (M:F=35:48) born at the University Clinic for Gynecology and Obstetrics in Skopje (hospitalized in the NICU) who were found to have hypoglycemia...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28583603/influence-of-prenatal-maternal-corticosteroid-therapy-on-clinical-and-metabolic-features-and-pulmonary-function-of-preterm-newborn-puppies
#14
F M Regazzi, L C G Silva, C F Lúcio, G A L Veiga, D S R Angrimani, D Kishi, M M M Barbosa, C I Vannucchi
Although the effects of antenatal corticosteroid therapy in clinical improvement and pulmonary maturation in preterm have been described, little is known on premature newborn puppies. This study aimed to evaluate the effect of maternal administration of a single dose of prenatal betamethasone on lung function of preterm newborn puppies in the first hours of life, especially from the clinical point of view and acid-base balance. A prospective study was conducted involving 21 puppies allocated into three experimental groups: Term Group (63 days post-ovulation), Preterm-Treated Group (57 days post-ovulation and maternal administration of a single dose of 0...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28576637/the-diagnosis-of-cystic-fibrosis
#15
Kris De Boeck, Francois Vermeulen, Lieven Dupont
Establishing the diagnosis of cystic fibrosis (CF) is straight forward in the majority of patients: they present with a clear clinical picture (most frequently chronic respiratory symptoms plus malabsorption), the sweat chloride value is>60mmol/L and two known disease causing CFTR mutations are identified. In less than 5% of subjects, mainly those with a milder or limited phenotype, the diagnostic process is more complex, because initial diagnostic test results are inconclusive: sweat chloride concentration in the intermediate range, less than 2 CF causing mutations identified or both...
May 30, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28576525/an-analysis-of-hearing-screening-test-results-in-2291-premature-infants-of-chinese-population
#16
Lili Huang, Fei Xiong, Jinrong Li, Fan Yang
OBJECTIVE: The aim of this study was to analyze the hearing screening program among preterm infants as well as to identify risk factors associated with failing primary newborn hearing screening. METHODS: The retrospectively selected population included all preterm infants who had primary hearing screening in a neonatal ward from January 1st, 2013 to December 31st, 2015 at West China Second University Hospital, Sichuan University. The newborn hearing screening (NHS) procedure was performed in all preterm infants by automated auditory brainstem response (AABR)...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28572501/reflex-cardiorespiratory-events-from-esophageal-origin-are-heightened-by-preterm-birth
#17
Stéphanie Nault, Nathalie Samson, Charlène Nadeau, Djamal Djeddi, Jean-Paul Praud
The involvement of gastroesophageal refluxes in cardiorespiratory events of preterm infants remains controversial. While a few studies in full term newborn animals have shown that stimulation of esophageal receptors leads to cardiorespiratory reflexes, the latter remain largely unknown, especially after premature birth. The present study aimed to i) characterize the cardiorespiratory reflexes originating from esophageal receptors in newborn lambs, and ii) test the hypotheses that preterm birth enhances reflex cardiorespiratory inhibition and that C-fibers are involved in these reflexes...
June 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28571898/-recommendations-for-respiratory-support-in-the-newborn-iv-high-frequency-ventilation-ex-utero-intrapartum-treatment-exit-extracorporeal-membrane-oxygenation-ecmo
#18
Félix Castillo Salinas, Dolores Elorza Fernández, Antonio Gutiérrez Laso, Julio Moreno Hernando, Gerardo Bustos Lozano, Manuel Gresa Muñoz, Xavier Miracle Echegoyen
The recommendations included in this document will be part a series of updated reviews of the literature on respiratory support in the newborn infant. These recommendations are structured into 12 modules, and in this work module 8 is presented. Each module is the result of a consensus process amongst all members of the Surfactant and Respiratory Group of the Spanish Society of Neonatology. They represent a summary of the published papers on each specific topic, as well as the clinical experience of each one of the members of the group...
May 29, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28565900/the-impact-of-intrauterine-growth-restriction-on-respiratory-outcomes
#19
Bárbara Oliveira, Filipa Flôr-DE-Lima, Gustavo Rocha, Manuela Rodrigues, Rita Ladeiras, Hercília Guimarães
BACKGROUND: Intrauterine growth restriction (IUGR) is caused by fetal growth below what is normal for its genetic potential. Recent studies have shown a distinct association between changes in umbilical artery flow in IUGR subjects and an increased risk of respiratory morbidity and was to find the impact of IUGR on the respiratory outcomes of premature neonates born with less than 32 weeks gestational age. METHODS: This retrospective cohort study targeted infants born with less than 32 weeks of gestation, admitted at NCIU, between January 2010 and December 2016...
May 31, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28560819/radiographic-assessment-of-pulmonary-fluid-clearance-and-lung-aeration-in-newborn-calves-delivered-by-elective-caesarean-section
#20
M K Abdelmegeid, O Kutasi, M N Nassiff, K Wirth, E Bodai, F Farrag, L Molnár, O Szenci
The aim of this study was to develop a radiographic standard for the assessment of pulmonary fluid clearance and lung aeration in newborn calves. Caesarean-delivered mature calves (n = 9) underwent lung assessment by thoracic radiography as well as arterial and venous blood gas analysis within the first 30 min, 1, 2, 3, 6, 12 and 24 hr after birth. The results indicated that newborn calves delivered by elective Caesarean section suffered from a physiological combined respiratory and metabolic acidosis with the dominance of respiratory acidosis, and an improvement in these conditions was recorded within 24 hr after birth...
May 30, 2017: Reproduction in Domestic Animals, Zuchthygiene
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