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https://www.readbyqxmd.com/read/28527570/mechanisms-of-glucocorticoid-action-during-development
#1
Jonathan T Busada, John A Cidlowski
Glucocorticoids are primary stress hormones produced by the adrenal cortex. The concentration of serum glucocorticoids in the fetus is low throughout most of gestation but surge in the weeks prior to birth. While their most well-known function is to stimulate differentiation and functional development of the lungs, glucocorticoids also play crucial roles in the development of several other organ systems. Mothers at risk of preterm delivery are administered glucocorticoids to accelerate fetal lung development and prevent respiratory distress...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28525961/passive-and-active-immunization-against-respiratory-syncytial-virus-for-the-young-and-old
#2
Tonya Villafana, Judith Falloon, M Pamela Griffin, Qing Zhu, Mark T Esser
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants worldwide and also causes significant disease in the elderly. Despite 60 years of RSV research and vaccine development, there is only one approved medicine to prevent RSV infections. Palivizumab, a monoclonal antibody (mAb) against the RSV fusion (F) protein, is indicated for preterm infants and children at high-risk for RSV infections. It is an active time in RSV vaccine and mAb development with 14 vaccines and 2 mAbs currently being tested in clinical trials as of 13 February 2017...
May 19, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28521272/impact-of-prematurity-on-exercise-capacity-and-agility-of-children-and-youth-aged-8-to-18
#3
Tatjana Robič Pikel, Gregor Starc, Janko Strel, Marjeta Kovač, Janez Babnik, Petra Golja
BACKGROUND: Preterm (PT) birth and low birth mass (LBW) can impair growth and development of children and may therefore affect their physical performance up to adulthood. AIMS: Our aim was to evaluate long-term consequences of prematurity, especially (an)aerobic exercise capacity and agility up to adulthood, by comparing premature and full-term (FT) individuals. STUDY DESIGN, SUBJECTS: From 474 subjects born in 1987, who were enrolled into a longitudinal study, 396 (178 PT and 218 FT (with 127 of them LBW)) were followed-up into their early adulthood...
May 15, 2017: Early Human Development
https://www.readbyqxmd.com/read/28520902/early-acquisition-of-pneumocystis-jirovecii-colonization-and-potential-association-with-respiratory-distress-syndrome-in-preterm-newborn-infants
#4
Pilar Rojas, Vicente Friaza, Elisa Garcia, Carmen de la Horra, Sergio L Vargas, Enrique J Calderón, Antonio Pavón
Background: Pneumocystis pneumonia is a well-recognized lung disease of premature and malnourished babies. Even though, serologic studies have shown that children are exposed to Pneumocystis jirovecii early in life the epidemiology of human P. jirovecii infection and the host-microorganism relationship in infancy remain poorly understood. The aim of the present study was to investigate the prevalence of P. jirovecii colonization in preterm infants and its possible association with medical complications...
May 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28514958/neonatal-respiratory-morbidity-following-exposure-to-chorioamnionitis
#5
Amy Metcalfe, Sarka Lisonkova, Yasser Sabr, Amelie Stritzke, K S Joseph
BACKGROUND: There are conflicting results in the literature on the impact of chorioamnionitis on neonatal respiratory morbidities. However, most studies are based on small clinical samples and fail to account for the competing risk of perinatal death. This study aimed to determine whether chorioamnionitis affects the incidence of respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) after accounting for the increased risk of death. METHODS: Retrospective cohort study using linked birth and infant death registration and hospitalization records from Washington State between 2002 and 2011 (n = 763,671 singleton infants and n = 56,537 singleton preterm infants)...
May 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28514777/direct-measurement-of-tissue-oxygenation-in-neonates-via-resonance-raman-spectroscopy-a-pilot-study
#6
Anjali Iyengar, Andrew Gaillardetz, Hocine Tighiouart, Betsabee Castillo, Padraic Romfh, Jonathan M Davis
BACKGROUND: The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures. Resonance Raman spectroscopy noninvasively measures tissue oxygenation (RRS-StO2). Peripheral tissue oxygenation using this novel technology has not been described in neonates. OBJECTIVES: To examine the relationship between short-term RRS-StO2 measurements and central venous saturation (ScvO2) and pulse oximetry (SpO2) in preterm and term neonates...
May 18, 2017: Neonatology
https://www.readbyqxmd.com/read/28501874/screening-tool-for-early-postnatal-prediction-of-retinopathy-of-prematurity-in-preterm-newborns-step-rop
#7
Caroline A Ricard, Christiane E L Dammann, Olaf Dammann
BACKGROUND: Retinopathy of prematurity (ROP) is a disorder of the preterm newborn characterized by neurovascular disruption in the immature retina that may cause visual impairment and blindness. OBJECTIVE: To develop a clinical screening tool for early postnatal prediction of ROP in preterm newborns based on risk information available within the first 48 h of postnatal life. METHODS: Using data submitted to the Vermont Oxford Network (VON) between 1995 and 2015, we created logistic regression models based on infants born <28 completed weeks gestational age...
May 13, 2017: Neonatology
https://www.readbyqxmd.com/read/28493508/apgar-score-components-at-5-minutes-risks-and-prediction-of-neonatal-mortality
#8
Sven Cnattingius, Mikael Norman, Fredrik Granath, Gunnar Petersson, Olof Stephansson, Thomas Frisell
BACKGROUND: The Apgar score consists of five components: heart rate, respiratory effort, muscle tone, reflex irritability, and colour. Although the Apgar score has been used for 60 years, the specific contribution of the Apgar score components with respect to risks and prediction of neonatal mortality remains unknown. Likewise, the value of reduced scores (including less than five Apgar score components) has rarely been investigated. METHODS: In a population-based cohort study of 148 765 liveborn singleton infants in Sweden 2008-2013, we investigated components of Apgar score at 5 min with respect to relative risks and prediction (using ROC curves, sensitivity, and positive predictive values) of neonatal mortality...
May 11, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28492159/iloprost-instillation-in-two-neonates-with-pulmonary-hypertension
#9
Sezin Unal, Selma Aktas, Meltem Aksu, Ibrahim M Hirfanoglu, Yildiz Atalay, Canan Turkyilmaz
Pulmonary hypertension may coexist with certain diseases in neonates. Iloprost inhalation is one of the treatments which cause selective pulmonary vasodilatation. Inhalation is not an easy way of drug administration in mechanically ventilated infants; as some exhibit desaturations during inhalation. Moreover, inhalation of drug requires cessation of mechanical ventilation, if patient is on high frequency oscillatory ventilation. We presented two patients with pulmonary hypertension; term baby with congenital diaphragmatic hernia and preterm baby with respiratory distress syndrome; who had iloprost instillation during mechanical ventilation treatment...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28488361/clonidine-for-sedation-and-analgesia-for-neonates-receiving-mechanical-ventilation
#10
REVIEW
Olga Romantsik, Maria Grazia Calevo, Elisabeth Norman, Matteo Bruschettini
BACKGROUND: Although routine administration of pharmacologic sedation or analgesia during mechanical ventilation in preterm neonates is not recommended, its use in clinical practice remains common. Alpha-2 agonists, mainly clonidine and dexmedetomidine, are used as adjunctive (or alternative) sedative agents alongside opioids and benzodiazepines. Clonidine has not been systematically assessed for use in neonatal sedation during ventilation. OBJECTIVES: To assess whether clonidine administered to term and preterm newborn infants receiving mechanical ventilation reduces morbidity and mortality rates...
May 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28487624/clara-cell-protein-expression-in-mechanically-ventilated-term-and-preterm-infants-with-respiratory-distress-syndrome-and-at-risk-of-bronchopulmonary-dysplasia-a-pilot-study
#11
José Guzmán-Bárcenas, Antonio Calderón-Moore, Héctor Baptista-González, Claudine Irles
The aim of this pilot study was to determine Clara cell protein (CC16) concentration in bronchoalveolar lavages (BAL) fluid from full-term and preterm (<37 weeks' gestational age) neonates requiring respiratory support, having symptoms of neonatal respiratory distress syndrome, and at risk of bronchopulmonary dysplasia (BPD). We hypothesized that CC16 may be predictive of BPD diagnosis regardless of gestational age. BAL fluid CC16 was measured by ELISA at birth and at day 7 of life. Both groups that developed BPD showed significantly decreased BAL fluid CC16 levels compared to those infants that did not develop the disease...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28486361/universal-cervical-length-screening-and-antenatal-corticosteroid-timing
#12
Nicole Sahasrabudhe, Catherine Igel, Ghislaine C Echevarria, Peʼer Dar, Diana Wolfe, Peter S Bernstein, Robert Angert, Ashlesha Dayal, Patience Gallagher, Mara Rosner
OBJECTIVE: To evaluate the relationship between universal transvaginal screening for short cervical length in the second trimester and the timing of antenatal corticosteroids. METHODS: We performed a retrospective cohort study of patients with nonanomalous singleton gestations and spontaneous preterm birth between 24 and 34 weeks of gestation after the initiation of a universal transvaginal cervical length screening program between October 2012 and August 2015. Our primary outcome was antenatal corticosteroid administration to a delivery interval of fewer than 7 days...
May 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28483192/no-association-between-influenza-vaccination-during-pregnancy-and-adverse-birth-outcomes
#13
Ousseny Zerbo, Sharareh Modaressi, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Bruce Fireman, Nicola P Klein, Roger Baxter
BACKGROUND: Pregnant women are recommended to receive inactivated influenza vaccination anytime during pregnancy. Studies have investigated the impact of influenza vaccination during pregnancy on birth outcomes and results on preterm birth have been inconsistent. METHODS: We conducted a retrospective cohort study among children born at a gestational age≥24weeks from January 1, 2010 to December 31, 2015 at Kaiser Permanente Northern California facilities (KPNC)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28477341/inflation-pressures-and-times-during-initial-resuscitation-of-preterm-infants
#14
Prashanth Bhat, Katie Hunt, Christopher Harris, Vadivelam Murthy, Anthony D Milner, Anne Greenough
BACKGROUND: The optimal combination of inflation pressures and times to produce adequate expiratory tidal volumes during initial resuscitation in prematurely born infants has not been determined. Our aim was to assess combinations of inflation pressures and times and the resulting expiratory tidal volume levels using a respiratory function monitor. METHODS: Sixty-four infants born before 34 weeks of gestation were studied. The infants were divided according to whether the inflation pressures (PIP-PEEP) were less than or >20 cm H2 O during the first five inflations delivered by a face mask and those groups were subdivided according to whether the inflation times were less than or > 1...
May 6, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28474588/comparative-efficacy-and-safety-of-caffeine-and-aminophylline-for-apnea-of-prematurity-in-preterm-%C3%A2-34-weeks-neonates-a-randomized-controlled-trial
#15
M Shivakumar, P Jayashree, Muhammad Najih, Leslie Edward Simon Lewis, Ramesh Bhat Y, Asha Kamath, - Shashikala
OBJECTIVE: To compare the efficacy and safety of standard doses of Caffeine and Aminophylline for Apnea of prematurity. STUDY DESIGN: Randomized controlled trial. SETTING: Tertiary-care referral centre and a teaching institution in Southern India. Trial was conducted from February 2012 to January 2015. PARTICIPANTS: 240 preterm (≤34 wk) neonates with apnea of prematurity. INTERVENTIONS: Neonates randomized into two groups: Caffeine group received loading dose of caffeine citrate (20 mg/kg) followed by 5 mg/kg/day maintenance dose every 24 hour...
April 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28472058/poractant-alfa-versus-bovine-lipid-extract-surfactant-for-infants-24-0-to-31-6-weeks-gestational-age-a-randomized-controlled-trial
#16
Brigitte Lemyre, Christoph Fusch, Georg M Schmölzer, Nicole Rouvinez Bouali, Deepti Reddy, Nicholas Barrowman, Nicole Huneault-Purney, Thierry Lacaze-Masmonteil
OBJECTIVES: To compare the efficacy and safety of poractant alfa and bovine lipid extract surfactant in preterm infants. STUDY DESIGN: Randomized, partially-blinded, multicenter trial. Infants <32 weeks needing surfactant before 48 hours were randomly assigned to receive poractant alfa or bovine lipid extract surfactant. The primary outcome was being alive and extubated at 48 hours post-randomization. Secondary outcomes included need for re-dosing, duration of respiratory support and oxygen, bronchopulmonary dysplasia, mortality and complications during administration...
2017: PloS One
https://www.readbyqxmd.com/read/28471526/preterm-infants-at-discharge-nap-polysomnography-versus-24-hour-oximetry
#17
Tamsin Roberts, Angela Campbell, Peter Larsen, Dawn Elder
AIM: This study aimed to determine whether measures of intermittent hypoxia derived from 24-hour oximetry correlate with measures of apnoea derived from modified nap polysomnography undertaken for preterm infants before discharge. METHODS: Infants born ≤32 weeks gestation were recruited from the Neonatal Intensive Care Unit, and had a modified polysomnography to assess their respiratory stability once they were ≥35 weeks postmenstrual age. Infants were defined as unstable if they had more than 10 obstructive events per hour or any apnoea of > 20 seconds in length...
May 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28465315/a-first-in-human-clinical-study-of-a-new-sp-b-and-sp-c-enriched-synthetic-surfactant-chf5633-in-preterm-babies-with-respiratory-distress-syndrome
#18
David G Sweet, Mark A Turner, Zbyněk Straňák, Richard Plavka, Paul Clarke, Ben J Stenson, Dominique Singer, Rangmar Goelz, Laura Fabbri, Guido Varoli, Annalisa Piccinno, Debora Santoro, Christian P Speer
OBJECTIVE: CHF5633 (Chiesi Farmaceutici S.p.A., Parma, Italy) is the first fully synthetic surfactant enriched by peptide analogues of two human surfactant proteins. We planned to assess safety and tolerability of CHF5633 and explore preliminary efficacy. DESIGN: Multicentre cohort study. PATIENTS: Forty infants from 27(+0) to 33(+6) weeks gestation with respiratory distress syndrome requiring fraction of inspired oxygen (FiO2) ≥0.35 were treated with a single dose of CHF5633 within 48 hours after birth...
May 2, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28462606/perinatal-outcome-in-pregnancy-with-polyhydramnios-in-comparison-with-normal-pregnancy-in-department-of-obstetrics-at-shiraz-university-of-medical-sciences
#19
Nasrin Asadi, Azadeh Khalili, Zahra Zarei, Arsalan Azimi, Maryam Kasraeian, Leila Forouginia, Ali Reza Salehi, Reza Ravanbod, Sarah Davoodi, Homeira Vafaei
OBJECTIVE: Polyhydraminos can lead to maternal and fetal complication during pregnancy, so diagnosis and management can decrease some perinatal complications. STUDY DESIGN: 114 singleton pregnancies were diagnosed with idiopathic polyhydramnios in the department of obstetrics at Shiraz University of Medical Sciencesbetween January 2000 and January 2011 were compared with 114 normal pregnancies for their perinatal outcome. Variables include birth weight, admission toneonatal intensive care unit (NICU), meconium staining, respiratory distress, fetal death,neonatal death,low 1 minute and 5minute APGAR score, primary cesarean section(C/S), preterm delivery (<37 weeks),postpartum bleeding and placental abruption...
May 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28459720/intravenous-caffeine-rescue-for-postoperative-hypoventilation-in-a-16-year-old-with-trisomy-10-a-case-report
#20
Michael Evans, Humphrey Lam, Thomas Austin
Trisomy 10 is a rare disorder, with only 35 cases reported in the literature. Anesthetic management may be challenging in this patient population because of craniofacial, cardiac, and renal abnormalities commonly seen in the disorder. We describe a 16-year-old male with an anesthetic history notable for prolonged emergence, postoperative hypoxia, postoperative reintubation, and unexpected hospital admission presenting for dental extraction of impacted teeth. We utilized intravenous caffeine, a respiratory stimulant used in preterm infants, to facilitate recovery from anesthesia...
April 28, 2017: A & A Case Reports
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