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Diclofenac sodium topical gel

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https://www.readbyqxmd.com/read/27887033/skin-irritation-and-sensitization-potential-of-fixed-dose-combination-of-diclofenac-1-and-menthol-3-topical-gel-results-of-two-phase-i-patch-studies
#1
D Jeffery Liu, A Collaku, J S Dosik
Phase I, randomized, controlled patch studies were conducted to evaluate skin sensitization and irritation potential of a new gel formulation containing 1% diclofenac and 3% menthol as a fixed-combination product.In study A, healthy volunteers were exposed to 4 test patches containing 1% diclofenac+3% menthol, diclofenac, menthol, or placebo gels during an induction (nine 48 to 72-h applications) and challenge phase (one 48-h application). Some subjects were re-challenged to evaluate suspected sensitization...
November 25, 2016: Drug Research
https://www.readbyqxmd.com/read/27882527/diclofenac-induced-allergic-contact-dermatitis-a-series-of-four-patients
#2
Sandra Jerkovic Gulin, Anca Chiriac
Allergic contact dermatitis is an immune-mediated antigen-specific skin reaction to an allergenic chemical that corresponds to a delayed-type hypersensitivity response (type IV reaction). Allergic contact dermatitis should be suspected when skin lesions are localized to the site of previous applications of the culprit drug. Lesions appear after re-exposure in susceptible persons, with delayed onset (more than 24 h after exposure). The gold standard for diagnosis is patch (epicutaneous) testing; identification and removal of any potential causal agents is crucial...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27789369/gellan-gum-fluid-gels-for-topical-administration-of-diclofenac
#3
Mohammed H Mahdi, Barbara R Conway, Thomas Mills, Alan M Smith
Diclofenac topical formulations are often preferred for drug administration to patients who experience serious GIT problems. Absorption of the drug through the skin, however, can be challenging due to the natural protective feature of the stratum corneum (SC). In this article, fluid gels prepared from gellan gum were explored as a topical drug delivery vehicle. Rheological analysis of the formulations showed that it was possible to produce a topical gel with a viscosity and the mechanical strength similar to that of the commercially available Voltaren(®) gel using 1% w/w of a 50:50 low acyl/high acyl (LA/HA) gellan blend...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27689135/topical-colchicine-gel-versus-diclofenac-sodium-gel-for-the-treatment-of-actinic-keratoses-a-randomized-double-blind-study
#4
Gita Faghihi, Azam Elahipoor, Fariba Iraji, Shadi Behfar, Bahareh Abtahi-Naeini
Introduction. Actinic keratoses (AKs), a premalignant skin lesion, are a common lesion in fair skin. Although destructive treatment remains the gold standard for AKs, medical therapies may be preferable due to the comfort and reliability .This study aims to compare the effects of topical 1% colchicine gel and 3% diclofenac sodium gel in AKs. Materials and Methods. In this randomized double-blind study, 70 lesions were selected. Patients were randomized before receiving either 1% colchicine gel or 3% diclofenac sodium cream twice a day for 6 weeks...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27617470/diclofenac-sodium-3-gel-for-darier-s-disease-treatment
#5
Sergio Santos-Alarcon, Celia Sanchis-Sanchez, Almudena Mateu-Puchades
BACKGROUND: Darier's disease (DD) is an autosomal dominant skin disorder which causative gene, ATP2A2, is located atchromosome 12q23-24. The lesions of DD are skin-coloured to brown, hyperkeratotic, greasy papules that coalesce into warty plaques commonly involving the seborrhoeic areas of the trunk and face, especially the scalp margins, temples, ears, and scalp. The most common complaint associated with the disease is itching, with exacerbations attributed to heat, sweating, sunlight, lithium, steroid therapy, stress, and menstruation OBJECTIVES: We report a patient with DD treated with topical diclofenac sodium 3%...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27412526/variability-in-conditioned-pain-modulation-predicts-response-to-nsaid-treatment-in-patients-with-knee-osteoarthritis
#6
Robert R Edwards, Andrew J Dolman, Marc O Martel, Patrick H Finan, Asimina Lazaridou, Marise Cornelius, Ajay D Wasan
BACKGROUND: Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinical pain measures, it is unknown whether individual variability in quantitative sensory testing (QST) responses at baseline can prospectively predict analgesic treatment responses. METHOD: Patients with knee OA (n = 35) were compared on QST responses to a demographically-matched pain-free control group (n = 39), after which patients completed a month-long treatment study of diclofenac sodium topical gel (1 %), applied up to 4 times daily...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27260133/development-of-gellan-gum-containing-formulations-for-transdermal-drug-delivery-component-evaluation-and-controlled-drug-release-using-temperature-responsive-nanogels
#7
Carlos A Carmona-Moran, Oleksandra Zavgorodnya, Andrew D Penman, Eugenia Kharlampieva, S Louis Bridges, Robert W Hergenrother, Jasvinder A Singh, Timothy M Wick
Enhancing skin permeation is important for development of new transdermal drug delivery formulations. This is particularly relevant for non-steroidal anti-inflammatory drugs (NSAIDs). To address this, semisolid gel and solid hydrogel film formulations containing gellan gum as a gelling agent were developed and the effects of penetration enhancers (dimethyl sulfoxide, isopropyl alcohol and propylene glycol) on transport of the NSAID diclofenac sodium was quantified. A transwell diffusion system was used to accelerate formulation development...
July 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27142000/preliminary-investigation-of-the-effects-of-topical-mixture-of-lawsonia-inermis-l-and-ricinus-communis-l-leaves-extract-in-treatment-of-osteoarthritis-using-mia-model-in-rats
#8
Atousa Ziaei, Shamim Sahranavard, Mohammad Javad Gharagozlou, Mehrdad Faizi
BACKGROUND: Many plants have been introduced in Iranian traditional medicine for treatment of different joint problems including knee pain. Topical application of the mixture of Lawsonia inermis L. leaves (Henna) with aqueous extract of Ricinus communis L. leaves have been mentioned to have significant effects on reducing knee pain. The present study was designed to evaluate the analgesic and anti-inflammatory effects of the mixture of these two herbs in male rats. METHODS: We induced knee osteoarthritis as a model of chronic pain by intra-articular injection of mono sodium iodoacetate (MIA)...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27067393/the-effect-of-topical-diclofenac-3-and-calcitriol-3%C3%A2-%C3%AE-g-g-on-superficial-basal-cell-carcinoma-sbcc-and-nodular-basal-cell-carcinoma-nbcc-a-phase-ii-randomized-controlled-trial
#9
Tjinta Brinkhuizen, Kiki J A Frencken, Patty J Nelemans, Marlou L S Hoff, Nicole W J Kelleners-Smeets, Axel Zur Hausen, Michiel P J van der Horst, Dorit Rennspiess, Véronique J L Winnepenninckx, Maurice A M van Steensel, Klara Mosterd
BACKGROUND: Nonsteroidal anti-inflammatory drugs and vitamin-D derivatives can target signaling pathways activated in basal cell carcinoma (BCC). OBJECTIVE: We investigated the efficacy of topically applied diclofenac sodium 3% gel, calcitriol 3 μg/g ointment, and a combination of both in superficial BCC (sBCC) and nodular BCC. METHODS: Patients with a primary, histologically proven sBCC (n = 64) or nodular BCC (n = 64) were randomized to topical diclofenac, calcitriol, combination of both, or no topical treatment (control group)...
July 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27021759/evaluation-of-resource-utilization-and-treatment-patterns-in-patients-with-actinic-keratosis-in-the-united-states
#10
COMPARATIVE STUDY
Carl V Asche, Panagiotis Zografos, Jenny M Norlin, Bill Urbanek, Carl Mamay, Charles Makin, Sandra Erntoft, Chi-Chang Chen, Dionne M Hines, Daniel Mark Siegel
OBJECTIVE: To compare health care resource utilization and treatment patterns between patients with actinic keratosis (AK) treated with ingenol mebutate gel (IngMeb) and those treated with other field-directed AK therapies. METHODS: A retrospective, propensity-score-matched, cohort study compared refill/repeat and adding-on/switching patterns and outpatient visits and prescriptions (health care resource utilization) over 6 months in patients receiving IngMeb versus those receiving imiquimod, 5-fluorouracil, diclofenac sodium, and methyl aminolevulinate or aminolevulinic acid photodynamic therapy (MAL/ALA-PDT)...
March 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26506138/efficacy-and-safety-of-diclofenac-sodium-2-topical-solution-for-osteoarthritis-of-the-knee-a-randomized-double-blind-vehicle-controlled-4-week-study
#11
RANDOMIZED CONTROLLED TRIAL
L Tyler Wadsworth, Jeffrey D Kent, Robert J Holt
OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are standard therapy for osteoarthritis (OA). Topically applied NSAIDs reduce systemic exposure compared with oral NSAIDS, and European guidelines recommend their use. The NSAID diclofenac is available in a range of topical formulations. Diclofenac 1% gel and 1.5% four times daily and 2% twice daily (BID) solutions are approved to reduce pain from OA of the knee(s). The objective of this study was to investigate the efficacy and safety of diclofenac sodium 2% topical solution BID versus vehicle control solution for treating pain associated with OA of the knee...
2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26352120/retrospective-evaluation-on-the-analgesic-activities-of-2-compounded-topical-creams-and-voltaren-gel-in-chronic-noncancer-pain
#12
John C Somberg, Janos Molnar
Pharmacologic treatment of chronic pain is challenging. Oral therapy may require multiple medications; each has side effects, dose limitations, and limited efficacy. Compounded topical formulations have evolved as potential treatment options. The objective of this study was to evaluate the efficacy of 2 compounded topical creams, "Cream I" and "Cream II," in patients with chronic extremity, joint, musculoskeletal, neuropathic, or other chronic topical pain conditions and compare their efficacy with Voltaren gel...
September 2015: American Journal of Therapeutics
https://www.readbyqxmd.com/read/25963327/advances-in-nsaid-development-evolution-of-diclofenac-products-using-pharmaceutical-technology
#13
REVIEW
Roy Altman, Bill Bosch, Kay Brune, Paola Patrignani, Clarence Young
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many traditional NSAIDs, diclofenac inhibits cyclooxygenase (COX)-2 enzyme with greater potency than it does COX-1. Similar to other NSAIDs, diclofenac is associated with serious dose-dependent gastrointestinal, cardiovascular, and renal adverse effects. Since its introduction in 1973, a number of different diclofenac-containing drug products have been developed with the goal of improving efficacy, tolerability, and patient convenience...
May 2015: Drugs
https://www.readbyqxmd.com/read/25853969/transdermal-absorption-enhancing-effect-of-the-essential-oil-of-rosmarinus-officinalis-on-percutaneous-absorption-of-na-diclofenac-from-topical-gel
#14
Jafar Akbari, Majid Saeedi, Davood Farzin, Katayoun Morteza-Semnani, Zahra Esmaili
CONTEXT: Rosemary essential oil has been used topically for several purposes (analgesic, anti acne, and anti-inflammatory) in Iranian traditional medicine. OBJECTIVES: This investigation aimed to study the effect of essential oil of Rosmarinus officinalis L. (Lamiaceae) on the transdermal absorption of Na diclofenac from topical gel. MATERIAL AND METHODS: Diclofenac sodium topical gel was prepared with HPMC K4M and Carbopol 934P as a gelling agent, and several vehicles...
2015: Pharmaceutical Biology
https://www.readbyqxmd.com/read/25758411/effect-of-microporation-on-passive-and-iontophoretic-delivery-of-diclofenac-sodium
#15
Hiren Patel, Abhay Joshi, Amit Joshi, Grazia Stagni
Skin pretreatment with a microneedle roller (microporation (MP)) appears a simple and inexpensive technique to increase transdermal delivery of topically applied drug products. This study investigates the effect of MP on the passive and iontophoretic delivery of diclofenac (DCF) by quantifying dermis and plasma levels of DCF in a rabbit model. New Zealand albino female rabbits received either: (i) a topical application of 4 g of Voltaren® 1% gel with or without pretreatment with a microroller (0.5 mm needle length; density 23 microneedles per cm(2) area) or (ii) a DCF solution (40 mg/2...
2015: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/25746267/characterization-of-supramolecular-gels-based-on-%C3%AE-cyclodextrin-and-polyethyleneglycol-and-their-potential-use-for-topical-drug-delivery
#16
Amornrat Klaewklod, Vimon Tantishaiyakul, Namon Hirun, Tanatchaporn Sangfai, Lin Li
Novel gels were prepared by blending β-cyclodextrin and polyethyleneglycol (PEG) in the presence of K2CO3. The objective of this study was thus to characterize the gels using rheology, modulated temperature differential scanning calorimetry (MTDSC), turbidity measurements, and hot stage microscopy, and then investigate the potential use of the gel for topical drug delivery. Two types of supramolecular gels, GelL and GelH were prepared at a low temperature (below 50 °C) and at a high temperature (above 70 °C), respectively...
May 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/25633158/delayed-onset-muscle-soreness-a-pilot-study-to-assess-analgesic-study-design-features
#17
RANDOMIZED CONTROLLED TRIAL
Neil Singla, Paul J Desjardins, Evelyn B Cosca, Cherri Parulan, Anne Arriaga, Kelly C Poole, Dan M Batz, Phoebe D Chang
Based on a thorough review of the available literature in the delayed-onset muscle soreness (DOMS) model, we identified multiple study design characteristics that are considered to be normative in acute pain research but have not been followed in a majority of published DOMS experiments. We designed an analgesic investigation using the DOMS model that both complied with current scientifically accepted standards for the conduct of analgesic studies and demonstrated reasonable assay sensitivity. This randomized, double-blind, placebo-controlled within-subject study compared the efficacy of topical diclofenac sodium 1% with a matching placebo in reducing pain associated with DOMS...
June 2015: Pain
https://www.readbyqxmd.com/read/25501873/influence-of-colloidal-silicon-dioxide-on-gel-strength-robustness-and-adhesive-properties-of-diclofenac-gel-formulation-for-topical-application
#18
Zheng Lu, Reza Fassihi
The objective of this study is to identify the extent of stiffness, adhesiveness, and thixotropic character of a three-dimensional gel network of a 1% diclofenac sodium topical gel formulation in the presence and absence of colloidal silicon dioxide (CSD) and assess its ease of application and adhesiveness using both objective and subjective analysis. The 1% diclofenac gel was mixed with different amounts of CSD (e.g., 0.5, 1, 2, 3, and 5% w/w) and allowed to equilibrate prior to testing. The texture analyzer in combination with a cone-cap assembly was used to objectively investigate the changes in spreadability and adhesiveness of the gel system before and after addition of CSD...
June 2015: AAPS PharmSciTech
https://www.readbyqxmd.com/read/25319056/development-and-evaluation-of-curcumin-loaded-elastic-vesicles-as-an-effective-topical-anti-inflammatory-formulation
#19
Rumjhum Agrawal, Simarjot Kaur Sandhu, Ikksheta Sharma, Indu Pal Kaur
Curcumin has diverse biological activities including antioxidant and anti-inflammatory activity. However, its clinical use for topical application is limited due to its poor aqueous solubility and thus, minimal cutaneous bioavailability. Elastic vesicles (EVs) of curcumin were prepared to improve its cutaneous bioavailability and to use it for topical anti-inflammatory effect. Ex vivo skin permeation and retention studies were performed to check if incorporation of curcumin into EVs could improve its permeation into and retention in the skin...
April 2015: AAPS PharmSciTech
https://www.readbyqxmd.com/read/25120467/sequential-treatment-of-multiple-actinic-keratoses-with-solaraze-and-actikerall
#20
Thomas Dirschka, John T Lear
Interest is increasing in the use of sequential or combined therapeutic modalities for spot or area treatment of actinic keratoses (AKs) to achieve complete sustained remission. For multiple lesions in a contained area, topical treatment offers less discomfort, better cosmesis and greater patient convenience than destructive/ablative techniques. Twelve patients with multiple grade I and II AK lesions of the scalp (cases 1-10) or the dorsum of the hand (cases 11 and 12), most with a history of recurrence, were treated with Solaraze gel (3% diclofenac sodium in 2...
May 2014: Case Reports in Dermatology
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