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basiliximab and lymphopenia

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https://www.readbyqxmd.com/read/20136785/the-number-of-circulating-recent-thymic-emigrants-is-severely-reduced-1-year-after-a-single-dose-of-alemtuzumab-in-renal-transplant-recipients
#1
Mirko Scarsi, Nicola Bossini, Fabio Malacarne, Francesca Valerio, Silvio Sandrini, Paolo AirĂ²
To better understand the kinetics of the delayed reconstitution of peripheral CD4+ T-cells after depletion with a single administration of alemtuzumab (AL) for renal transplantation, we evaluated in these patients the percentage and absolute number of recent thymic emigrants (RTEs) CD4+ T cells, together with naive and memory subsets, defined by the analysis of CD31, CD45RA and CCR7 expression, and compared with patients treated with a nondepleting protocol based on basiliximab, and with healthy controls. In AL-treated patients, the number of circulating CD4+ T cells was greatly reduced 1 year after the infusion (P < 0...
August 2010: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/20112478/thymoglobulin-new-approaches-to-optimal-outcomes
#2
REVIEW
Andreea Delia Moicean, Anca Maria Popp, Ioanel Sinescu
Thymoglobulin has a proven safety and efficacy profile both as treatment of acute rejection and as induction therapy in organ transplantation. The most common adverse events associated with Thymoglobulin are cytokine release syndrome, thrombocytopenia, and lymphopenia. Results of early studies showed an increased rate of cytomegalovirus disease associated with Thymoglobulin treatment, but recent studies indicate that routine administration of modern antiviral prophylaxis can reduce this risk. More research comparing Thymoglobulin with basiliximab will help individualize regimens by matching the choice of induction agent with the risk profile of each transplant recipient...
July 2009: Journal of Medicine and Life
https://www.readbyqxmd.com/read/19715923/delayed-graft-function-is-reduced-with-antithymocyte-globulin-induction-in-pediatric-kidney-transplantation
#3
R Vilalta, E Lara, A Madrid, S Chocron, A Vazquez, A Casquero, J Nieto
Reduction of delayed graft function (DGF) is critical to the success of renal transplantation. We report graft outcomes with antithymocyte globulin (ATG) induction compared with using interleukin-2 receptor antagonist basiliximab (IL-2RA). Twelve pediatric patients received a pediatric deceased donor kidney. We treated them with ATG (group A, ATG; n = 6) or IL-2RA (group B, n = 6). DGF was observed in 0 cases (group A) and in 6 cases (group B), which showed a mean of 7 +/- 3 days (P < .001). In group A, lymphopenia occurred routinely resolving after 3-6 months, none with serious infection...
July 2009: Transplantation Proceedings
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