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High dose influenza vaccine

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https://www.readbyqxmd.com/read/28958811/parental-perceptions-of-childhood-seasonal-influenza-vaccination-in-singapore-a-cross-sectional-survey
#1
Mabel S F Low, Hweeyong Tan, Mikael Hartman, Clarence C Tam, Cheehow Hoo, Jiaqing Lim, Simin Chiow, Simin Lee, Renzhi Thng, Mingzhe Cai, Yanru Tan, Jingzhan Lock
PURPOSE: Seasonal influenza vaccination is recommended in children aged 6-59months, but little is known about child vaccination coverage and determinants in Asian settings. We report the results of a survey of knowledge, attitudes, practices, and determinants of child influenza vaccination in Singapore. METHODS: In December 2015-March 2016, we conducted a survey of 332 parents of children aged 6months to 5years attending pre-schools. We assessed child influenza vaccine coverage and parental knowledge, attitudes, and practices of child influenza vaccination...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28958701/influenza-vaccine-mediated-protection-in-older-adults-impact-of-influenza-infection-cytomegalovirus-serostatus-and-vaccine-dosage
#2
Shahzma Merani, George A Kuchel, Alison Kleppinger, Janet E McElhaney
Age-related changes in T-cell function are associated with a loss of influenza vaccine efficacy in older adults. Both antibody and cell-mediated immunity plays a prominent role in protecting older adults, particularly against the serious complications of influenza. High dose (HD) influenza vaccines induce higher antibody titers in older adults compared to standard dose (SD) vaccines, yet its impact on T-cell memory is not clear. The aim of this study was to compare the antibody and T-cell responses in older adults randomized to receive HD or SD influenza vaccine as well as determine whether cytomegalovirus (CMV) serostatus affects the response to vaccination, and identify differences in the response to vaccination in those older adults who subsequently have an influenza infection...
September 25, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28957006/recombinant-avian-paramyxovirus-serotypes-2-6-and-10-as-vaccine-vectors-for-highly-pathogenic-avian-influenza-in-chickens-with-antibodies-against-newcastle-disease-virus
#3
Ryota Tsunekuni, Hirokazu Hikono, Taichiro Tanikawa, Riho Kurata, Takaaki Nakaya, Takehiko Saito
Recombinant Newcastle disease virus (rNDV) expressing the hemagglutinin of highly pathogenic avian influenza virus (HPAIV HA) induces protective immunity against HPAIV in chickens. However, the efficacy of rNDV vectors is hampered when chickens are pre-immune to NDV, and most commercial chickens are routinely vaccinated against NDV. We recently showed that avian paramyxovirus serotypes 2, 6, and 10 (APMV-2, APMV-6, and APMV-10), which belong to the same genus as NDV, have low cross-reactivity with anti-NDV antisera...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28941982/immune-efficacy-of-an-adenoviral-vector-based-swine-influenza-vaccine-against-antigenically-distinct-h1n1-strains-in-mice
#4
Yunpu Wu, Dawei Yang, Bangfeng Xu, Wenhua Liang, Jinyu Sui, Yan Chen, Huanliang Yang, Hualan Chen, Ping Wei, Chuanling Qiao
Avian-like H1N1 swine influenza viruses are prevalent in pigs and have occasionally crossed the species barrier and infected humans, which highlights the importance of preventing swine influenza. Human adenovirus serotype 5 (Ad5) has been tested in human influenza vaccine clinical trials and has exhibited a reliable safety profile. Here, we generated a replication-defective, recombinant adenovirus (designated as rAd5-avH1HA) expressing the hemagglutinin gene of an avian-like H1N1 virus (A/swine/Zhejiang/199/2013, ZJ/199/13)...
September 20, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28934770/seasonal-influenza-and-vaccination-strategies-is-a-paradigm-shift-needed-a-synopsis-of-the-3rd-new-zealand-influenza-symposium-november-2016
#5
Nadia A Charania, Diana Murfitt, Nikki Turner
Influenza continues to be a global public health problem despite the availability of preventive vaccines and public health vaccination programmes. This paper presents a synopsis of the 3rd New Zealand Influenza Symposium (NZiS) that was hosted by the Immunisation Advisory Centre (IMAC) in November 2016. Experts and service providers convened to discuss current issues in the prevention and management of influenza. One of the key topics discussed was the use of novel vaccines, such as adjuvanted and high-dose vaccines, and antiviral prophylaxis to protect young children and the elderly...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934456/cross-reactive-antibody-responses-to-novel-h5nx-influenza-viruses-following-homologous-and-heterologous-prime-boost-vaccination-with-a-prepandemic-stockpiled-a-h5n1-vaccine-in-humans
#6
Min Z Levine, Crystal Holiday, Feng Liu, Stacie Jefferson, Eric Gillis, Abbie R Bellamy, Terrence Tumpey, Jacqueline M Katz
Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.3.4.4) caused outbreaks in US poultry. We evaluated the potential of a stockpiled A(H5N1) A/Anhui/1/2005 (clade 2.3.4) vaccine to elicit cross-reactive antibody responses to these emerging viruses. Sera from subjects who received 2 doses of MF59-adjuvanted A/Anhui/1/2005, or 1 dose of MF59-adjuvanted A/Anhui/1/2005 following priming with a clade 1 vaccine were characterized by microneutralization assays and modified hemagglutination inhibition (HI) assays...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934453/an-adjuvanted-a-h5n1-subvirion-vaccine-elicits-virus-specific-antibody-response-and-improves-protection-against-lethal-influenza-viral-challenge-in-mouse-model-of-protein-energy-malnutrition
#7
Enitra N Jones, Samuel Amoah, Weiping Cao, Suryaprakash Sambhara, Shivaprakash Gangappa
Background: Protein energy malnutrition (PEM) increases susceptibility to infectious diseases, including influenza infection, but no studies have addressed the potential influences of PEM on the immunogenicity and protective efficacy of avian influenza A(H5N1) vaccine. Methods: We investigated the role of PEM on vaccine-mediated protection after a lethal challenge with recombinant A(H5N1) virus using isocaloric diets providing either adequate protein (AP; 18% protein) or very low protein (VLP; 2% protein) in an established murine model of influenza vaccination...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931425/neutralizing-immune-responses-induced-by-oligomeric-h5n1-hemagglutinins-from-plants
#8
Hoang Trong Phan, Thuong Thi Ho, Ha Hoang Chu, Trang Huyen Vu, Ulrike Gresch, Udo Conrad
Plant-based transient expression is an alternative platform to produce hemagglutinin-based subunit vaccines. This production system provides not only fast and effective response in the context of a pandemic but also enables the supply of big volume vaccines at low cost. Crude plant extracts containing influenza hemagglutinin are considered to use as vaccine sources because of avoidance of related purification steps resulting in low cost production allowing veterinary applications. Highly immunogenic influenza hemagglutinins are urgently required to meet these pre-conditions...
September 20, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28928207/a-perfect-storm-increased-colonization-and-failure-of-vaccination-leads-to-severe-secondary-bacterial-infection-in-influenza-virus-infected-obese-mice
#9
Erik A Karlsson, Victoria A Meliopoulos, Nicholas C van de Velde, Lee-Ann van de Velde, Beth Mann, Geli Gao, Jason Rosch, Elaine Tuomanen, Jon McCullers, Peter Vogel, Stacey Schultz-Cherry
Obesity is a risk factor for developing severe disease following influenza virus infection; however, the comorbidity of obesity and secondary bacterial infection, a serious complication of influenza virus infections, is unknown. To fill this gap in knowledge, lean and obese C57BL/6 mice were infected with a nonlethal dose of influenza virus followed by a nonlethal dose of Streptococcus pneumoniae Strikingly, not only did significantly enhanced death occur in obese coinfected mice compared to lean controls, but also high mortality was seen irrespective of influenza virus strain, bacterial strain, or timing of coinfection...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28917539/hemagglutinin-specific-cd4-t-cell-responses-following-2009-ph1n1-inactivated-split-vaccine-inoculation-in-humans
#10
Shuguang Tan, Shihong Zhang, Bin Wu, Yingze Zhao, Wei Zhang, Min Han, Ying Wu, Guoli Shi, Yingxia Liu, Jinghua Yan, Guizhen Wu, Hua Wang, George F Gao, Fengcai Zhu, William J Liu
Influenza A virus remains a major threat to public health, and the inactivated split-virus vaccine is the most prevalent vaccine used worldwide. However, our knowledge about cellular immune responses to the inactivated influenza virus vaccine and its correlation with humoral responses are yet limited, which has restricted our understanding of the vaccine's protective mechanisms. Herein, in two clinical trials, T-cell responses specific for both previously identified human leucocyte antigen (HLA)-I-restricted epitopes from influenza virus and hemagglutinin (HA) protein were longitudinally investigated before, during, and after a two-dose vaccination with the inactivated 2009 pandemic H1N1 (2009-pH1N1) vaccine...
September 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28903749/modelling-the-effects-of-booster-dose-vaccination-schedules-and-recommendations-for-public-health-immunization-programs-the-case-of-haemophilus-influenzae-serotype-b
#11
Nadia A Charania, Seyed M Moghadas
BACKGROUND: Haemophilus influenzae serotype b (Hib) has yet to be eliminated despite the implementation of routine infant immunization programs. There is no consensus regarding the number of primary vaccine doses and an optimal schedule for the booster dose. We sought to evaluate the effect of a booster dose after receiving the primary series on the long-term disease incidence. METHODS: A stochastic model of Hib transmission dynamics was constructed to compare the long-term impact of a booster vaccination and different booster schedules after receiving the primary series on the incidence of carriage and symptomatic disease...
September 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28899814/single-immunization-with-mf59-adjuvanted-inactivated-whole-virion-h7n9-influenza-vaccine-provides-early-protection-against-h7n9-virus-challenge-in-mice
#12
Haiyan Chang, Jie Duan, Peng Zhou, Ling Su, Dan Zheng, Fenghua Zhang, Fang Fang, Xiaoman Li, Ze Chen
H7N9 influenza infection in humans would result in severe respiratory illness. Vaccination is the best way to prevent influenza virus. In this paper, we investigated the effect of early protection provided by inactivated whole-virion H7N9 influenza vaccine in a mouse model. Mice were immunized intramuscularly once with different doses of inactivated whole-virion H7N9 influenza vaccine alone or in combination with MF59 adjuvant. Specific IgM and IgG antibody titers in sera of mice were detected by ELISA 3, 5 and 7days after immunization...
September 9, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28890196/cost-effectiveness-and-public-health-impact-of-alternative-influenza-vaccination-strategies-in-high-risk-adults
#13
Jonathan M Raviotta, Kenneth J Smith, Jay DePasse, Shawn T Brown, Eunha Shim, Mary Patricia Nowalk, Angela Wateska, Glenson S France, Richard K Zimmerman
PURPOSE: High-dose trivalent inactivated influenza vaccine (HD-IIV3) or recombinant trivalent influenza vaccine (RIV) may increase influenza vaccine effectiveness (VE) in adults with conditions that place them at high risk for influenza complications. This analysis models the public health impact and cost-effectiveness (CE) of these vaccines for 50-64year-olds. METHODS: Markov model CE analysis compared 5 strategies in 50-64year-olds: no vaccination; only standard-dose IIV3 offered (SD-IIV3 only), only quadrivalent influenza vaccine offered (SD-IIV4 only); high-risk patients receiving HD-IIV3, others receiving SD-IIV3 (HD-IIV3 & SD-IIV3); and high-risk patients receiving HD-IIV3, others receiving SD-IIV4 (HD-IIV3 & SD-IIV4)...
October 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28883971/vaccination-of-hiv-infected-pregnant-women-implications-for-protection-of-their-young-infants
#14
REVIEW
Ziyaad Dangor, Marta C Nunes, Gaurav Kwatra, Sanjay G Lala, Shabir A Madhi
BACKGROUND: The prevention of mother to child transmission of HIV has resulted in reduced burden of pediatric HIV-infection, but the prevalence of maternal HIV infection remains high in sub-Saharan African countries. HIV-exposed-uninfected infants have an increased risk of morbidity and mortality due to infectious diseases than HIV-unexposed infants, particularly during the first six months of life, which in part might be due to lower levels of pathogen-specific protective antibodies acquired transplacentally from their mothers...
2017: Tropical Diseases, Travel Medicine and Vaccines
https://www.readbyqxmd.com/read/28866291/a-single-dose-and-long-lasting-vaccine-against-pandemic-influenza-through-the-controlled-release-of-a-heterospecies-tandem-m2-sequence-embedded-within-detoxified-bacterial-outer-membrane-vesicles
#15
Hannah C Watkins, Catalina L Pagan, Hannah R Childs, Sara Posada, Annie Chau, Jose Rios, Cassandra Guarino, Matthew P DeLisa, Gary R Whittaker, David Putnam
The influenza A virus undergoes genetic drift and shift, leaving the general population susceptible to emerging pandemic strains, despite seasonal flu vaccination. Here we describe a single dose influenza vaccine derived from recombinant outer membrane vesicles (rOMVs) that display an antigen-mapped heterospecies tandem sequence of the M2 protein from the influenza A virus, released over 30days from poly(lactic-co-glycolide) (PLGA) microparticles. Four weeks post vaccination, BALB/c mice developed high anti-M2e IgG titers that were equivalent to those generated at 8weeks in a typical prime/boost vaccine regimen...
September 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28866290/immunogenicity-safety-and-reactogenicity-of-the-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv-in-2-17-year-old-children-with-asplenia-or-splenic-dysfunction-a-phase-3-study
#16
L Szenborn, I V Osipova, H Czajka, S M Kharit, T Jackowska, N François, M A Habib, D Borys
BACKGROUND: Immunization with pneumococcal vaccines is an important prophylactic strategy for children with asplenia or splenic dysfunction, who are at high risk of bacterial infections (including S. pneumoniae). This study aimed to assess immunogenicity and safety of pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV, GSK) in this at-risk population. METHODS: This phase III, multi-centre, open-label, controlled study, in which at-risk children with asplenia or splenic dysfunction were enrolled (age strata: 2-4, 5-10 and 11-17years), was conducted in Poland and the Russian Federation...
September 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28862177/effect-of-disease-modifying-antirheumatic-drug-therapy-on-immune-response-to-trivalent-influenza-vaccine-in-rheumatoid-arthritis
#17
Vikramraj K Jain, Nandhini Bhashini, L Karthik Balajee, Sujatha Sistla, Subhash Chandra Parija, Vir Singh Negi
BACKGROUND & OBJECTIVES: Patients with autoimmune rheumatic diseases may be at an increased risk of infection due to disease and use of disease-modifying antirheumatic drug (DMARD) therapy. The present study was done to evaluate the immune response to influenza vaccination in patients with rheumatoid arthritis (RA). METHODS: Fifty one RA patients on stable methotrexate (MTX) therapy (≥15 mg/wk), 51 newly diagnosed DMARD-naïve RA patients and 45 healthy controls received a single dose of inactivated seasonal trivalent influenza vaccine...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28844407/novel-hemagglutinin-nanoparticle-influenza-vaccine-with-matrix-m%C3%A2-adjuvant-induces-hemagglutination-inhibition-neutralizing-and-protective-responses-in-ferrets-against-homologous-and-drifted-a-h3n2-subtypes
#18
Gale Smith, Ye Liu, David Flyer, Michael J Massare, Bin Zhou, Nita Patel, Larry Ellingsworth, Maggie Lewis, James F Cummings, Greg Glenn
Influenza viruses frequently acquire mutations undergoing antigenic drift necessitating annual evaluation of vaccine strains. Highly conserved epitopes have been identified in the hemagglutinin (HA) head and stem regions, however, current influenza vaccines induce only limited responses to these conserved sites. Here, we describe a novel seasonal recombinant HA nanoparticle influenza vaccine (NIV) formulated with a saponin-based adjuvant, Matrix-M™. NIV induced hemagglutination inhibition (HAI) and microneutralizing (MN) antibodies against a broad range of influenza A(H3N2) subtypes...
September 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28841693/the-effect-of-aqueous-extract-of-xinjiang-artemisia-rupestris-l-an-influenza-virus-vaccine-adjuvant-on-enhancing-immune-responses-and-reducing-antigen-dose-required-for-immunity
#19
Ailian Zhang, Danyang Wang, Jinyao Li, Feng Gao, Xucheng Fan
Potent adjuvant can improve the effectiveness of vaccines and reduce the antigen doses required for initiating the protective immunity. In this study, we identified that aqueous extract of Artemisia rupestris L. (AEAR) could be employed as an efficient adjuvant for influenza virus vaccine (V) to enhance immune responses and reduce the antigen doses required for initiating immunity, without compromising the immune response. ICR mice were subcutaneously co-administrated with V combined with different concentrations of AEAR demonstrated that 300 μg AEAR could significantly improve hemagglutination inhibition (HI) and increase IgG antibody titers in serum (P<0...
2017: PloS One
https://www.readbyqxmd.com/read/28754488/survey-of-distribution-of-seasonal-influenza-vaccine-doses-in-201-countries-2004-2015-the-2003-world-health-assembly-resolution-on-seasonal-influenza-vaccination-coverage-and-the-2009-influenza-pandemic-have-had-very-little-impact-on-improving-influenza-control
#20
A Palache, A Abelin, R Hollingsworth, W Cracknell, C Jacobs, T Tsai, P Barbosa
There is no global monitoring system for influenza vaccination coverage, making it difficult to assess progress towards the 2003 World Health Assembly (WHA) vaccination coverage target. In 2008, the IFPMA Influenza Vaccine Supply International Task Force (IVS) developed a survey method to assess the global distribution of influenza vaccine doses as a proxy for vaccination coverage rates. The latest dose distribution data for 2014 and 2015 was used to update previous analyses. Data were confidentially collected and aggregated by the IFPMA Secretariat, and combined with previous IFPMA IVS survey data (2004-2013)...
July 25, 2017: Vaccine
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