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High dose influenza vaccine

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https://www.readbyqxmd.com/read/29660994/providing-additional-muscle-for-older-adults-through-optimal-influenza-vaccine-selection
#1
John A Dougherty, Elias B Chahine
Immunization is the best strategy to protect individuals from influenza; however, older adults tend to respond less favorably to vaccines because of immunosenescence. The Centers for Disease Control and Prevention states that any licensed, recommended, and age-appropriate influenza vaccine may be used in older adults despite reasonable evidence suggesting that the high-dose and, to a lesser extent, the adjuvanted and recombinant influenza vaccines provide better protection than the standard-dose vaccines in this vulnerable population...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29624615/efficacy-and-synergy-of-live-attenuated-and-inactivated-influenza-vaccines-in-young-chickens
#2
Hyesun Jang, Mohamed Elaish, Mahesh Kc, Michael C Abundo, Amir Ghorbani, John M Ngunjiri, Chang-Won Lee
Outbreaks of novel highly pathogenic avian influenza viruses have been reported in poultry species in the United States since 2014. These outbreaks have proven the limitations of biosecurity control programs, and new tools are needed to reinforce the current avian influenza control arsenal. Some enzootic countries have implemented inactivated influenza vaccine (IIV) in their control programs, but there are serious concerns that a long-term use of IIV without eradication may result in the selection of novel antigenically divergent strains...
2018: PloS One
https://www.readbyqxmd.com/read/29620467/the-effect-of-infectious-bursal-disease-virus-induced-immunosuppression-on-vaccination-against-highly-pathogenic-avian-influenza-virus
#3
Erica Spackman, Christopher B Stephens, Mary J Pantin-Jackwood
Poor efficacy of avian influenza virus (AIV) vaccines in chickens has been documented in the field in spite of good results in experimental settings. Although the causes are multifactorial and complex, one contributing factor may be prior infection with immunosuppressive viruses. In an effort to evaluate the role of immunosuppressive agents on AIV pathogenesis and vaccine efficacy, the effect of prior infection with infectious bursal disease virus (IBDV), a ubiquitous immunosuppressive virus of chickens, was evaluated...
March 2018: Avian Diseases
https://www.readbyqxmd.com/read/29617814/a-respiratory-syncytial-virus-vaccine-based-on-the-small-hydrophobic-protein-ectodomain-presented-with-a-novel-lipid-based-formulation-is-highly-immunogenic-and-safe-in-adults-a-first-in-humans-study
#4
Joanne M Langley, Lisa D MacDonald, Genevieve M Weir, Donna MacKinnon-Cameron, Lingyun Ye, Shelly McNeil, Bert Schepens, Xavier Saelens, Marianne M Stanford, Scott A Halperin
Background: Respiratory Syncytial Virus infection can cause lower respiratory tract infection in older adults comparable to influenza, but no vaccines are available. Methods: This was a randomized, observer blinded first-in-humans study of a novel synthetic RSV antigen SHe, formulated with either the lipid and oil-based vaccine platform, DepoVaxTM, termed DPX-RSV(A), or with alum, termed (RSV(A) SHe, in healthy 50-64-year-old adults. Two dose levels (10 or 25 µg) of the SHe antigen with each formulation were compared to placebo...
March 30, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29615248/a-two-dose-immunization-with-an-inactivated-reassortant-h5n2-virus-protects-chickens-against-lethal-challenge-with-homologous-2-3-2-1-clade-and-heterologous-2-2-clade-highly-pathogenic-avian-influenza-h5n1-viruses
#5
Sushant Bhat, Richa Sood, Shweta Shukla, Rekha Khandia, Atul Kumar Pateriya, Naveen Kumar, Vikas Kumar Singh, Semmannan Kalaiyarasu, Manoj Kumar, Sandeep Bhatia
The present study was aimed at generating a reassortant vaccine candidate virus with clade 2.3.2.1 Hemagglutinin (HA) and its evaluation in a challenge study for protection against homologous (2.3.2.1 clade) and heterologous (2.2 clade) highly pathogenic avian influenza (HPAI) H5N1 viruses. Plasmid-based reverse genetics technique was used to rescue a 5 + 3 reassortant H5N2 strain containing the modified HA of H5N1 (clade 2.3.2.1), the Neuraminidase (NA) of H9N2, the Matrix (M) of H5N1 and the internal genes of A/WSN/33 H1N1...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29582403/medications-and-prescribing-patterns-as-factors-associated-with-hospitalizations-from-long-term-care-facilities-a-systematic-review
#6
REVIEW
Kate N Wang, J Simon Bell, Esa Y H Chen, Julia F M Gilmartin-Thomas, Jenni Ilomäki
BACKGROUND: Residents of long-term care facilities (LTCFs) are at high risk of hospitalization. Medications are a potentially modifiable risk factor for hospitalizations. OBJECTIVE: Our objective was to systematically review the association between medications or prescribing patterns and hospitalizations from LTCFs. METHODS: We searched MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and International Pharmaceutical Abstracts (IPA) from inception to August 2017 for longitudinal studies reporting associations between medications or prescribing patterns and hospitalizations...
March 26, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29576386/multiple-myeloma-clinical-updates-from-the-american-society-of-hematology-annual-meeting-2017
#7
REVIEW
Evangelos Terpos
The novel clinical data for myeloma that were presented in the 2017 Annual Meeting of the American Society of Hematology are summarized here. Studies with curative approach (CESAR) or prolonging progression-free survival (CENTAURUS) for patients with high-risk smoldering multiple myeloma (SMM) are described. Updated data from large phase III studies for patients with newly diagnosed MM (NDMM) who are eligible for autologous stem cell transplantation (ASCT) (EMN02, MRC XI) are described, along with the results of studies using novel anti-myeloma drug combinations for induction, consolidation, and maintenance as first-line therapy...
March 1, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29551225/immunogenicity-and-safety-of-a-trivalent-influenza-ha-vaccine-in-indonesian-infants-and-children
#8
Soedjatmiko Soedjatmiko, Bernie Endyarni Medise, Hartono Gunardi, Rini Sekartini, Hindra Irawan Satari, Sri Rezeki Hadinegoro, Novilia Sjafri Bachtiar, Rini Mulia Sari
INTRODUCTION: High rate of influenza infection in children made influenza vaccination strongly recommended for all person aged >6 months in Indonesia. Bio Farma Trivalent Influenza HA (Flubio®) vaccine has been used in adolescents and adults, resulted in increased seroconversion, seroprotection rates and geometric mean titer (GMT). However, no data is available regarding its efficacy and safety in children. This study aimed to assess the immunogenicity and safety of Flubio® vaccine in infants and children...
March 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29544989/effective-immunization-of-older-adults-against-seasonal-influenza
#9
REVIEW
William Schaffner, Wilbur H Chen, Robert H Hopkins, Kathleen Neuzil
The 2017-18 influenza season reminds us that it is important for healthcare professionals to be prepared for the annual onslaught of this contagious respiratory disease associated with potentially serious complications. Vaccination is by far the best method to prevent and control influenza, reducing illness, hospitalizations, and mortality. The highest rates of influenza-associated morbidity and mortality are observed in older adults. The immune function of older adults decreases with increasing age, a phenomenon termed immunosenescence...
March 12, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29541075/overcoming-the-neonatal-limitations-of-inducing-germinal-centers-through-liposome-based-adjuvants-including-c-type-lectin-agonists-trehalose-dibehenate-or-curdlan
#10
Maria Vono, Christiane Sigrid Eberhardt, Elodie Mohr, Floriane Auderset, Dennis Christensen, Mirco Schmolke, Rhea Coler, Andreas Meinke, Peter Andersen, Paul-Henri Lambert, Beatris Mastelic-Gavillet, Claire-Anne Siegrist
Neonates and infants are more vulnerable to infections and show reduced responses to vaccination. Consequently, repeated immunizations are required to induce protection and early life vaccines against major pathogens such as influenza are yet unavailable. Formulating antigens with potent adjuvants, including immunostimulators and delivery systems, is a demonstrated approach to enhance vaccine efficacy. Yet, adjuvants effective in adults may not meet the specific requirements for activating the early life immune system...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29521514/influenza-in-older-patients-a-call-to-action-and-recent-updates-for-vaccinations
#11
Miranda Wilhelm
Influenza affects millions of people in the United States each year. Older patients are particularly at risk for infection, hospitalization, and death due to influenza-related complications, such as pneumonia. One of the best ways to avoid becoming ill is to have the annual influenza vaccination. Unfortunately, immunization rates are poor in the older adult population, at about 65% each year. Vaccine effectiveness in this population is reduced because of lower seroconversion rates that arise from poorer immunologic response to vaccination...
March 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29521144/in-vitro-marker-gene-expression-analyses-in-human-peripheral-blood-mononuclear-cells-a-tool-to-assess-safety-of-influenza-vaccines-in-humans
#12
Eita Sasaki, Haruka Momose, Yuki Hiradate, Ken J Ishii, Takuo Mizukami, Isao Hamaguchi
Vaccines are inoculated in healthy individuals from children to the elderly, and thus high levels of safety and consistency of vaccine quality in each lot must meet the required specifications by using preclinical and lot release testing. Because vaccines are inoculated into humans, recapitulation of biological reactions in humans should be considered for test methods. We have developed a new method to evaluate the safety of influenza vaccines using biomarker gene expression in mouse and rat models. Some biomarker genes are already known to be expressed in human lymphocytes, macrophages and dendritic cells; therefore, we considered some of these genes might be common biomarkers for human and mice to evaluate influenza vaccine safety...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29519670/heterologous-two-dose-vaccination-with-simian-adenovirus-and-poxvirus-vectors-elicits-long-lasting-cellular-immunity-to-influenza-virus-a-in-healthy-adults
#13
L Coughlan, S Sridhar, R Payne, M Edmans, A Milicic, N Venkatraman, B Lugonja, L Clifton, C Qi, P M Folegatti, A M Lawrie, R Roberts, H de Graaf, P Sukhtankar, S N Faust, D J M Lewis, T Lambe, Avs Hill, S C Gilbert
BACKGROUND: T-cell responses against highly conserved influenza antigens have been previously associated with protection. However, these immune responses are poorly maintained following recovery from influenza infection and are not boosted by inactivated influenza vaccines. We have previously demonstrated the safety and immunogenicity of two viral vectored vaccines, modified vaccinia virus Ankara (MVA) and the chimpanzee adenovirus ChAdOx1 expressing conserved influenza virus antigens, nucleoprotein (NP) and matrix protein-1 (M1)...
February 15, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29485353/seasonal-influenza-vaccine-in-immunocompromised-persons
#14
Mohammad Bosaeed, Deepali Kumar
Immunocompromised persons are at high risk of complications from influenza infection. This population includes those with solid organ transplants, hematopoietic stem cell transplants, solid cancers and hematologic malignancy as well as those with autoimmune conditions receiving biologic therapies. In this review, we discuss the impact of influenza infection and evidence for vaccine effectiveness and immunogenicity. Overall, lower respiratory disease from influenza is common; however, vaccine immunogenicity is low...
February 27, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29484187/vaccinating-for-natural-killer-cell-effector-functions
#15
REVIEW
Helen R Wagstaffe, Jason P Mooney, Eleanor M Riley, Martin R Goodier
Vaccination has proved to be highly effective in reducing global mortality and eliminating infectious diseases. Building on this success will depend on the development of new and improved vaccines, new methods to determine efficacy and optimum dosing and new or refined adjuvant systems. NK cells are innate lymphoid cells that respond rapidly during primary infection but also have adaptive characteristics enabling them to integrate innate and acquired immune responses. NK cells are activated after vaccination against pathogens including influenza, yellow fever and tuberculosis, and their subsequent maturation, proliferation and effector function is dependent on myeloid accessory cell-derived cytokines such as IL-12, IL-18 and type I interferons...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29459062/cost-effectiveness-of-a-potential-vaccine-candidate-for-haemophilus-influenzae-serotype-a
#16
Affan Shoukat, Robert Van Exan, Seyed M Moghadas
The preceding decade has witnessed the emergence of severe community-acquired acute infections caused by Haemophilus influenzae serotype a (Hia), with alarming incidence rates in North America, particularly among indigenous populations. The remarkable success of Hib conjugate vaccine over the past 20 years signify the development of an Hia vaccine candidate as a prevention measure to reduce the incidence of invasive Hia disease. However, quantifications of the long-term epidemiologic and economic impacts of vaccination are needed to inform decision on investment in Hia vaccine development and immunization programs...
February 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29452380/relative-vaccine-effectiveness-of-high-dose-versus-standard-dose-influenza-vaccines-among-veterans-health-administration-patients
#17
Yinong Young-Xu, Robertus Van Aalst, Salaheddin M Mahmud, Kenneth J Rothman, Julia Thornton Snider, Daniel Westreich, Vincent Mor, Stefan Gravenstein, Jason K H Lee, Edward W Thommes, Michael D Decker, Ayman Chit
Background: To examine whether a high-dose inactivated influenza vaccine was more efficacious in preventing hospitalizations than a standard-dose vaccine in the Veterans Health Administration (VHA) senior population. Methods: This study estimated the relative vaccine effectiveness (rVE) of high-dose versus standard-dose using a retrospective cohort of VHA patients 65 years of age or older in the 2015-16 influenza season. To adjust for measured confounders, we matched each high-dose recipient with up to four standard-dose recipients vaccinated at the same location within a two-week period and having two or more pre-existing medical co-morbidities...
February 14, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29451833/development-and-pilot-testing-of-a-text-message-vaccine-reminder-system-for-use-during-an-influenza-pandemic
#18
Jonathan D Lehnert, Alex Shevach, Sydney Walker, Rose Wang, Thomas J Fitzgerald, Samuel B Graitcer
In an influenza pandemic, two vaccine doses administered 21 days apart may be needed for individuals of all ages to achieve seroprotection. Achieving dose-series completion can be challenging even for routinely recommended vaccines. To prepare for a two-dose influenza pandemic vaccine campaign and promote dose-series completion and correct dosing intervals, CDC and its partners developed a text message-based vaccine reminder system to remind persons who receive a first dose of pandemic influenza vaccine to receive the second dose...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29445377/mouse-models-of-influenza-infection-with-circulating-strains-to-test-seasonal-vaccine-efficacy
#19
Helen T Groves, Jacqueline U McDonald, Pinky Langat, Ekaterina Kinnear, Paul Kellam, John McCauley, Joanna Ellis, Catherine Thompson, Ruth Elderfield, Lauren Parker, Wendy Barclay, John S Tregoning
Influenza virus infection is a significant cause of morbidity and mortality worldwide. The surface antigens of influenza virus change over time blunting both naturally acquired and vaccine induced adaptive immune protection. Viral antigenic drift is a major contributing factor to both the spread and disease burden of influenza. The aim of this study was to develop better infection models using clinically relevant, influenza strains to test vaccine induced protection. CB6F1 mice were infected with a range of influenza viruses and disease, inflammation, cell influx, and viral load were characterized after infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29444167/rotavirus-vaccine-coverage-and-factors-associated-with-uptake-using-linked-data-ontario-canada
#20
Sarah E Wilson, Hannah Chung, Kevin L Schwartz, Astrid Guttmann, Shelley L Deeks, Jeffrey C Kwong, Natasha S Crowcroft, Laura Wing, Karen Tu
BACKGROUND: In August 2011, Ontario, Canada introduced a rotavirus immunization program using Rotarix™ vaccine. No assessments of rotavirus vaccine coverage have been previously conducted in Ontario. METHODS: We assessed vaccine coverage (series initiation and completion) and factors associated with uptake using the Electronic Medical Record Administrative data Linked Database (EMRALD), a collection of family physician electronic medical records (EMR) linked to health administrative data...
2018: PloS One
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