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High dose influenza vaccine

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https://www.readbyqxmd.com/read/28754488/survey-of-distribution-of-seasonal-influenza-vaccine-doses-in-201-countries-2004-2015-the-2003-world-health-assembly-resolution-on-seasonal-influenza-vaccination-coverage-and-the-2009-influenza-pandemic-have-had-very-little-impact-on-improving-influenza-control
#1
A Palache, A Abelin, R Hollingsworth, W Cracknell, C Jacobs, T Tsai, P Barbosa
There is no global monitoring system for influenza vaccination coverage, making it difficult to assess progress towards the 2003 World Health Assembly (WHA) vaccination coverage target. In 2008, the IFPMA Influenza Vaccine Supply International Task Force (IVS) developed a survey method to assess the global distribution of influenza vaccine doses as a proxy for vaccination coverage rates. The latest dose distribution data for 2014 and 2015 was used to update previous analyses. Data were confidentially collected and aggregated by the IFPMA Secretariat, and combined with previous IFPMA IVS survey data (2004-2013)...
July 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28737468/economic-evaluations-of-haemophilus-influenzae-type-b-hib-vaccine-a-systematic-review
#2
Bunchai Chongmelaxme, Maythika Hammanee, Wariya Phooaphirak, Surachai Kotirum, Raymond Hutubessy, Nathorn Chaiyakunapruk
AIMS: World Health Organization (WHO) recommends the use of Haemophilus influenzae type b (Hib) conjugate vaccines but only China and Thailand have not used Hib vaccination in their national immunization programs. This systematic review aimed to update published economic evaluations of Hib vaccinations and to determine factors that potentially affected their cost-effectiveness. METHODS: Searching was performed from the inception until December 2015 using 13 databases: CAB direct; CEA registry; EconLit; EMBASE; E-library; NHSEED; PAHO; POPLINE; PubMed; Redalyc project; RePEc; SciELO and WHOLIS...
July 24, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28736045/comparative-effectiveness-of-high-dose-versus-standard-dose-influenza-vaccination-on-numbers-of-us-nursing-home-residents-admitted-to-hospital-a-cluster-randomised-trial
#3
Stefan Gravenstein, H Edward Davidson, Monica Taljaard, Jessica Ogarek, Pedro Gozalo, Lisa Han, Vincent Mor
BACKGROUND: Immune responses to influenza vaccines decline with age, reducing clinical effectiveness. We compared the effect of the more immunogenic high-dose trivalent influenza vaccine with a standard-dose vaccine to identify the effect on reducing hospital admissions of nursing home residents in the USA. METHODS: We did a single-blind, pragmatic, comparative effectiveness, cluster-randomised trial with a 2 × 2 factorial design. Medicare-certified nursing homes in the USA located within 50 miles of a Centers for Disease Control and Prevention influenza reporting city were recruited, so long as the facilities were not located in a hospital, had more than 50 long-stay residents, had less than 20% of the population aged under 65 years, and were not already planning to administer the high-dose influenza vaccine to residents...
July 20, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28736044/high-dose-influenza-vaccine-in-nursing-home-residents-not-to-be-sneezed-at
#4
Marc-Alain Widdowson, Joseph S Bresee
No abstract text is available yet for this article.
July 20, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28729020/purification-of-cell-culture-derived-influenza-a-virus-via-continuous-anion-exchange-chromatography-on-monoliths
#5
Laura M Fischer, Michael W Wolff, Udo Reichl
The continuously increasing demand for potent and safe vaccines and the intensifying economic pressure on health care systems underlines the need for further optimization of vaccine manufacturing. Here, we focus on downstream processing of human influenza vaccines, investigating the purification of serum-free cell culture-derived influenza virus (A/PR/8/34 H1N1) using continuous chromatography. Therefore, quaternary amine anion exchange monoliths (CIM® QA) were characterized for their capacity to capture virus particles from animal cells cultivated in different media and their ability to separate virions from contaminating host cell proteins and DNA...
July 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28718786/egg-independent-influenza-vaccines-and-vaccine-candidates
#6
REVIEW
Ilaria Manini, Claudia Maria Trombetta, Giacomo Lazzeri, Teresa Pozzi, Stefania Rossi, Emanuele Montomoli
Vaccination remains the principal way to control seasonal infections and is the most effective method of reducing influenza-associated morbidity and mortality. Since the 1940s, the main method of producing influenza vaccines has been an egg-based production process. However, in the event of a pandemic, this method has a significant limitation, as the time lag from strain isolation to final dose formulation and validation is six months. Indeed, production in eggs is a relatively slow process and production yields are both unpredictable and highly variable from strain to strain...
July 18, 2017: Vaccines
https://www.readbyqxmd.com/read/28697286/annual-burden-of-occupationally-acquired-influenza-infections-in-hospitals-and-emergency-departments-in-the-united-states
#7
Rachael M Jones, Yulin Xia
Infections among health-care personnel (HCP) occur as a result of providing care to patients with infectious diseases, but surveillance is limited to a few diseases. The objective of this study is to determine the annual number of influenza infections acquired by HCP as a result of occupational exposures to influenza patients in hospitals and emergency departments (EDs) in the United States. A risk analysis approach was taken. A compartmental model was used to estimate the influenza dose received in a single exposure, and a dose-response function applied to calculate the probability of infection...
July 11, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28696824/age-appropriate-versus-up-to-date-coverage-of-routine-childhood-vaccinations-among-young-children-in-israel
#8
Chen Stein-Zamir, Avi Israeli
BACKGROUND AND AIMS: Routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. Vaccination coverage data are conventionally reported by the up-to-date method. We aimed to assess vaccination timeliness by the age-appropriate method and compare with the up-to-date vaccination coverage. METHODS: Assessment of age-appropriate and up-to-date vaccination coverage among children born in Israel in 2009 and followed to age 48 months (national representative sample, n = 3892)...
July 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28675269/-new-therapeutics
#9
Adriana Iacob Popescu, Liz Coronado, Aikaterini Efstathopoulou, Daniele Frisone, Gian-Marco Stamm, Javier Torralvo, Luc Barberini, Pierre-Auguste Petignat
Daily medical practice triggers reflexes in the use of drugs which must nevertheless always be adapted to new knowledge. Physician assistants and residents in the clinical ward of Internal Medicine of Sion Hospital summarize six recently published clinical treatments to which primary care physicians or in hospital-based internal medicine have to pay a particular attention. Quinolones are widely used but associated with QT interval widening, morphine delays and attenuate ticagrelor action in patients with myocardial infarction, evolocumab, a monoclonal antibody impact in reducing lipids and cardiovascular events, impact of statins on influenza vaccine effectiveness, vitamin D treatment for the prevention of functional decline, high dose dexamethasone for the treatment of immune thrombocytopenia...
September 7, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28662134/generation-of-monoclonal-pan-hemagglutinin-antibodies-for-the-quantification-of-multiple-strains-of-influenza
#10
Aziza P Manceur, Wei Zou, Anne Marcil, Eric Paquet, Christine Gadoury, Bozena Jaentschke, Xuguang Li, Emma Petiot, Yves Durocher, Jason Baardsnes, Manuel Rosa-Calatrava, Sven Ansorge, Amine A Kamen
Vaccination is the most effective course of action to prevent influenza. About 150 million doses of influenza vaccines were distributed for the 2015-2016 season in the USA alone according to the Centers for Disease Control and Prevention. Vaccine dosage is calculated based on the concentration of hemagglutinin (HA), the main surface glycoprotein expressed by influenza which varies from strain to strain. Therefore yearly-updated strain-specific antibodies and calibrating antigens are required. Preparing these quantification reagents can take up to three months and significantly slows down the release of new vaccine lots...
2017: PloS One
https://www.readbyqxmd.com/read/28642154/a-boosting-skin-vaccination-with-dissolving-microneedle-patch-encapsulating-m2e-vaccine-broadens-the-protective-efficacy-of-conventional-influenza-vaccines
#11
Wandi Zhu, Winston Pewin, Chao Wang, Yuan Luo, Gilbert X Gonzalez, Teena Mohan, Mark R Prausnitz, Bao-Zhong Wang
The biodegradable microneedle patch (MNP) is a novel technology for vaccine delivery that could improve the immunogenicity of vaccines. To broaden the protective efficiency of conventional influenza vaccines, a new 4M2e-tFliC fusion protein construct containing M2e sequences from different subtypes was generated. Purified fusion protein was encapsulate into MNPs with a biocompatible polymer for use as a boosting vaccine. The results demonstrated that mice receiving a conventional inactivated vaccine followed by a skin-applied dissolving 4M2e-tFliC MNP boost could better maintain the humoral antibody response than that by the conventional vaccine-prime alone...
September 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28633491/optimization-of-inactivated-h5n9-highly-pathogenic-avian-influenza-vaccine-and-inactivated-salmonella-enterica-serovar-typhimurium-vaccine-with-antigen-dose-and-prime-boost-regimen-in-domestic-ducks
#12
Seong-Su Yuk, Eredene-Ochir To, Jung-Hoon Kwon, Jin-Yong Noh, Woo-Tack Hong, Jei-Hyun Jeong, Gyeong-Bin Gwon, Chang-Seon Song
Owing to the increase in the number of diseases affecting ducks and the demand for food safety by consumers, vaccination has become one of the factors that influence duck meat productivity. The highly pathogenic avian influenza (HPAI) virus is one of the most prevalent and causes one of the most lethal diseases in domestic ducks, and Salmonella enterica serovar Typhimurium is a food-borne pathogen persistent in the domestic duck population. To better understand the optimal usage of HPAI and S. enterica serovar Typhimurium vaccines, we aimed to determine antigen dose, oil and gel adjuvant usage with prime-boost regimen, and vaccination age, inducing the best immune response in ducks, without an effect on body weight gain...
June 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28632298/patient-med-tbe-f%C3%A3-rb%C3%A3-ttrades-snabbt-vid-behandling-med-kortison-evidens-saknas-dock-f%C3%A3-r-v%C3%A3-rdet-av-immunmodulerande-terapi
#13
Carl Wengse, Jesper Ericsson, Susanna Hallberg, Johan Ursing
Rapid improvement of tick-borne encephalitis after treatment with corticosteroids Tick-borne encephalitis (TBE) is a viral disease transmitted by ticks. The virus is divided into three subtypes named Western, Siberian and Far Eastern TBE virus (TBEV). Western TBEV is endemic in parts of Europe and Sweden and typically causes a biphasic illness with influenza-like symptoms followed by neurological symptoms ranging from mild meningitis to severe meningoencephalitis and death. Despite an effective vaccine, TBE is increasing in Sweden and Europe...
June 16, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28628185/epidemiology-and-prevention-of-influenza-in-children-in-argentina-and-brazil
#14
(no author information available yet)
A group of influenza experts from Argentina and Brazil got together to discuss the burden of influenza in children, review current vaccine coverage rates in both countries, analyze vaccine effectiveness, and discuss strategies to improve prevention. Active surveillance of respiratory viruses is carried out nationwide in both countries. Years 2014 and 2015 were mild influenza seasons; influenza virus type A/H3N2 prevailed, whereas type B represented less than 30% of isolates. Trivalent inactivated influenza vaccine is included in National Immunization Programs for 1) children 6 months to 2 years old in Argentina; 2) children 6 months to 5 years old in Brazil; and 3) all high-risk individuals...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28622854/linear-dna-vaccine-prepared-by-large-scale-pcr-provides-protective-immunity-against-h1n1-influenza-virus-infection-in-mice
#15
Fei Wang, Quanjiao Chen, Shuntang Li, Chenyao Zhang, Shanshan Li, Min Liu, Kun Mei, Chunhua Li, Lixin Ma, Xiaolan Yu
Linear DNA vaccines provide effective vaccination. However, their application is limited by high cost and small scale of the conventional polymerase chain reaction (PCR) generally used to obtain sufficient amounts of DNA effective against epidemic diseases. In this study, a two-step, large-scale PCR was established using a low-cost DNA polymerase, RKOD, expressed in Pichia pastoris. Two linear DNA vaccines encoding influenza H1N1 hemagglutinin (HA) 1, LEC-HA, and PTO-LEC-HA (with phosphorothioate-modified primers), were produced by the two-step PCR...
June 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28554058/stockpiled-pre-pandemic-h5n1-influenza-virus-vaccines-with-as03-adjuvant-provide-cross-protection-from-h5n2-clade-2-3-4-4-virus-challenge-in-ferrets
#16
Xiangjie Sun, Jessica A Belser, Joanna A Pulit-Penaloza, Hannah M Creager, Zhu Guo, Stacie N Jefferson, Feng Liu, Ian A York, James Stevens, Taronna R Maines, Daniel B Jernigan, Jacqueline M Katz, Min Z Levine, Terrence M Tumpey
Avian influenza viruses, notably H5 subtype viruses, pose a continuous threat to public health due to their pandemic potential. In recent years, influenza virus H5 subtype split vaccines with novel oil-in-water emulsion based adjuvants (e.g. AS03, MF59) have been shown to be safe, immunogenic, and able to induce broad immune responses in clinical trials, providing strong scientific support for vaccine stockpiling. However, whether such vaccines can provide protection from infection with emerging, antigenically distinct clades of H5 viruses has not been adequately addressed...
August 2017: Virology
https://www.readbyqxmd.com/read/28533093/safety-and-immunogenicity-of-a-live-attenuated-influenza-h5-candidate-vaccine-strain-a-17-turkey-turkey-05-133-h5n2-and-its-priming-effects-for-potential-pre-pandemic-use-a-randomised-double-blind-placebo-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Punnee Pitisuttithum, Kobporn Boonnak, Supat Chamnanchanunt, Pilaipan Puthavathana, Viravarn Luvira, Hatairat Lerdsamran, Jaranit Kaewkungwal, Saranath Lawpoolsri, Vipa Thanachartwet, Udomsak Silachamroon, Wanibtisam Masamae, Alexandra Schuetz, Ponthip Wirachwong, Sit Thirapakpoomanunt, Larisa Rudenko, Erin Sparrow, Martin Friede, Marie-Paule Kieny
BACKGROUND: The emergence of highly pathogenic avian influenza H5N1 viruses has raised concerns about their pandemic potential. Vaccination is the most effective way of preventing influenza. In this study, we investigated the safety and immunogenicity of an avian H5N2 live attenuated influenza vaccine (LAIV H5N2) in healthy Thai adults and its priming immune responses with an H5N1 inactivated vaccine boost. METHODS: This study was done at the Vaccine Trial Centre at Mahidol University, Bangkok, Thailand and was divided into two parts...
August 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28480274/comparison-of-side-effects-of-the-2015-2016-high-dose-inactivated-trivalent-influenza-vaccine-and-standard-dose-inactivated-trivalent-influenza-vaccine-in-adults-%C3%A2-65-years
#18
Anjum S Kaka, Gregory A Filice, Sharon Myllenbeck, Kristin L Nichol
BACKGROUND: High-dose, inactivated, trivalent influenza vaccine (HD) is associated with higher rates of side effects than standard dose (SD) vaccine, which may represent a barrier to use. METHODS: We surveyed subjects ≥65 years who received either HD or SD vaccine at the Minneapolis Veteran Affairs Health Care System clinics on October 27, 28, or 29, 2015. Research assistants conducted a 17-item telephone survey of influenza vaccine recipients to inquire about self-reported health and symptoms experienced the week after vaccination...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28479181/carbohydrate-fatty-acid-monosulphate-esters-are-safe-and-effective-adjuvants-for-humoral-responses
#19
Luuk A Th Hilgers, Peter Paul L I Platenburg, Jeffrey Bajramovic, Jennifer Veth, Robert Sauerwein, Will Roeffen, Marie Pohl, Geert van Amerongen, Koert J Stittelaar, Johannes F van den Bosch
Carbohydrate fatty acid sulphate esters (CFASEs) formulated in a squalane-in-water emulsion are effective adjuvants for humoral responses to a wide range of antigens in various animal species but rise in body temperature and local reactions albeit mild or minimal hampers application in humans. In rabbits, body temperature increased 1°C one day after intramuscular (IM) injection, which returned to normal during the next day. The effect increased with increasing dose of CFASE but not with the number of injections (up to 5)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28469192/construction-of-a-highly-efficient-crispr-cas9-mediated-duck-enteritis-virus-based-vaccine-against-h5n1-avian-influenza-virus-and-duck-tembusu-virus-infection
#20
Zhong Zou, Kun Huang, Yanmin Wei, Huanchun Chen, Ziduo Liu, Meilin Jin
Duck enteritis virus (DEV), duck tembusu virus (DTMUV), and highly pathogenic avian influenza virus (HPAIV) H5N1 are the most important viral pathogens in ducks, as they cause significant economic losses in the duck industry. Development of a novel vaccine simultaneously effective against these three viruses is the most economical method for reducing losses. In the present study, by utilizing a clustered regularly interspaced short palindromic repeats (CRISPR)/associated 9 (Cas9)-mediated gene editing strategy, we efficiently generated DEV recombinants (C-KCE-HA/PrM-E) that simultaneously encode the hemagglutinin (HA) gene of HPAIV H5N1 and pre-membrane proteins (PrM), as well as the envelope glycoprotein (E) gene of DTMUV, and its potential as a trivalent vaccine was also evaluated...
May 3, 2017: Scientific Reports
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