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Elderly and influenza

Jennifer E Isenor, Jessica L Killen, Beverly A Billard, Shelly A McNeil, Donna MacDougall, Beth A Halperin, Kathryn L Slayter, Susan K Bowles
BACKGROUND: Annual immunization is the most effective way to prevent influenza and its associated complications. However, optimal immunization rates are not being met in Nova Scotia, Canada. Additional providers, such as pharmacists, may improve access and convenience to receive vaccines. Pharmacists began immunizing patients 5 years of age and older within the publicly funded universal influenza vaccination program during the 2013-2014 influenza season. The objective of this study was to evaluate influenza immunization coverage rates before and after pharmacists in Nova Scotia gained authority to immunize as part of the publicly funded universal influenza vaccination program...
2016: Journal of Pharmaceutical Policy and Practice
T Ilyicheva, A Durymanov, I Susloparov, N Kolosova, N Goncharova, S Svyatchenko, O Petrova, A Bondar, V Mikheev, A Ryzhikov
The influenza epidemic in 2015-2016 in Russia is characterized by a sharp increase of influenza cases (beginning from the second week of 2016) with increased fatalities. Influenza was confirmed in 20 fatal cases registered among children (0-10 years), in 5 cases among pregnant women, and in 173 cases among elderly people (60 years and older). Two hundred and ninety nine people died from influenza were patients with some chronic problems. The overwhelming majority among the deceased (more than 98%) were not vaccinated against influenza...
2016: PloS One
Marie-Odile Husson, Delphine Ley, Céline Portal, Madeleine Gottrand, Thomas Hueso, Jean-Luc Desseyn, Frédéric Gottrand
OBJECTIVES: Although n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) are used widely in the treatment of chronic inflammatory diseases, their effect in infectious disease requires a particular attention. METHODS: The present article discusses their anti-inflammatory and immune properties involved in the host defence and presents a systematic review of the effects of their oral administration on the prevention and outcome of experimental and clinical infections...
October 14, 2016: Journal of Infection
Juan Yang, Katherine E Atkins, Luzhao Feng, Mingfan Pang, Yaming Zheng, Xinxin Liu, Benjamin J Cowling, Hongjie Yu
BACKGROUND: To explore the current landscape of seasonal influenza vaccination across China, and estimate the budget of implementing a national "free-at-the-point-of-care" vaccination program for priority populations recommended by the World Health Organization. METHODS: In 2014 and 2016, we conducted a survey across provincial Centers for Disease Control and Prevention to collect information on regional reimbursement policies for influenza vaccination, estimated the national uptake using distributed doses of influenza vaccines, and evaluated the budget using population size and vaccine cost obtained from official websites and literatures...
October 13, 2016: Vaccine
Yik-Kei Chan, Rity Yk Wong, Margaret Ip, Nelson Ls Lee, Joyce Hs You
BACKGROUND: To describe direct medical costs of influenza in hospitalized elderly, with and without intensive care unit (ICU) admission, during the 2014-2015 season in Hong Kong. METHODS: A retrospective study was conducted in 110 inpatients aged ≥65 years with laboratory-confirmed influenza treated by antiviral therapy during season 2014-2015 in a tertiary hospital. Resource utilization of influenza-related diagnostic and laboratory tests, medications for influenza treatment, usage of general medical ward and ICU during the influenza-related length of hospital stay (IR-LOS) were collected...
October 14, 2016: Antiviral Therapy
Richard L Hodinka
Acute upper and lower respiratory infections are a major public health problem and a leading cause of morbidity and mortality worldwide. At greatest risk are young children, the elderly, the chronically ill, and those with suppressed or compromised immune systems. Viruses are the predominant cause of respiratory tract illnesses and include RNA viruses such as respiratory syncytial virus, influenza virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus. Laboratory testing is required for a reliable diagnosis of viral respiratory infections, as a clinical diagnosis can be difficult since signs and symptoms are often overlapping and not specific for any one virus...
August 2016: Microbiology Spectrum
J M Ramos, M M García-Navarro, M P González de la Aleja, R Sánchez-Martínez, A Gimeno-Gascón, S Reus, E Merino, J C Rodríguez-Díaz, J Portilla
OBJECTIVE: Seasonal influenza is responsible for high annual morbidity and mortality worldwide, especially in elderly patients. The aim of the study was to analyse the epidemiological, clinical and prognostic features of influenza in octogenarians and nonagenarians admitted to a general hospital, as well as risk factors associated with mortality. METHODS: Retrospective, cross-sectional, descriptive study in patients admitted and diagnosed with influenza by molecular biology in the General University Hospital of Alicante from 1 January to 31 April 2015...
October 7, 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Jonathan M Raviotta, Kenneth J Smith, Jay DePasse, Shawn T Brown, Eunha Shim, Mary Patricia Nowalk, Richard K Zimmerman
OBJECTIVES: To compare the cost-effectiveness of four influenza vaccines available in the United States for persons aged 65 and older: trivalent inactivated influenza vaccine (IIV3), quadrivalent inactivated influenza vaccine (IIV4), a more-expensive high-dose IIV3, and a newly approved adjuvanted IIV3. DESIGN: Cost-effectiveness analysis using a Markov model and sensitivity analyses. SETTING: A hypothetical influenza vaccination season modeled according to possible U...
October 2016: Journal of the American Geriatrics Society
Bernd Salzberger, Barbara Schmidt
The burden of disease of influenza in Germany has been dominated by high rates of complications in elderly patients in years with high circulation of H3N2 viruses after the introduction of the new H1N1 strain in 2009. Human infections with avian influenza viruses occur mostly in China. Due to the potential of reassortment with human strains these cases are monitored closely. The efficacy of neuraminidase inhibitors (NI) has been newly rated. In randomized studies effects on reduction of complications could not be found, although large cohort studies have demonstrated a reduction of mortality in patients treated with vs...
September 2016: Deutsche Medizinische Wochenschrift
Guillermo M Ruiz-Palacios, Geert Leroux-Roels, Jiri Beran, Jeanne-Marie Devaster, Meral Esen, Odile Launay, Janet E McElhaney, Gerrit A van Essen, Anne Benoit, Carine Claeys, Walthère Dewé, Christelle Durand, Xavier Duval, Ann R Falsey, Gregory Feldman, Florence Galtier, Pierre Gervais, Shinn-Jang Hwang, Shelly McNeil, Jan Hendrik Richardus, Andrew Trofa, Lidia Oostvogels
In this study we describe the immunogenicity results from a subset of older people (N = 5187) who participated in a Phase 3 randomized, observer-blinded trial of AS03-TIV versus TIV (Fluarix™) (, NCT00753272). Participants received one dose of AS03-TIV or TIV in each study year and antibody titers against the vaccine strains were assessed using hemagglutination-inhibition (HI) assay at 21 days and 180 days post-vaccination in each vaccine group in the 2008/09 (Year 1) and 2009/10 (Year 2) influenza seasons...
October 3, 2016: Human Vaccines & Immunotherapeutics
Fabíola Bof de Andrade, Ana Paula Sayuri Sato, Roudom Ferreira Moura, José Leopoldo Ferreira Antunes
This study aimed at assessing the factors associated with vaccine uptake in a representative sample of community-dwelling Brazilian older adults, specifically focusing on differences in socioeconomic factors among the country regions. We conducted a cross-sectional, population-based study, using a probabilistic household sample in 2013. Individuals aged 60 years or more answered a structured questionnaire informing on vaccination status and sociodemographic and behavioral covariates. Associations between variables were evaluated using prevalence ratios estimated by Poisson regression models...
October 3, 2016: Human Vaccines & Immunotherapeutics
Catia Cilloniz, Adrian Ceccato, Alicia San Jose, Antoni Torres
Community acquired pneumonia (CAP) is a major health problem in elderly persons and is associated with high morbidity and mortality. Areas covered: This article reviews the most recent publications relative to CAP in the elderly population, with a focus on epidemiology, prognostic factors, microbial etiology, therapy and prevention. The data discussed in this review were mainly obtained from a non-systematic review using Medline, and references from relevant articles. Expert Commentary: CAP can occur at any age, but its incidence and risk of death are linked to increasing age...
October 3, 2016: Expert Review of Respiratory Medicine
Ineke T Spruijt, Marit M A de Lange, Frederika Dijkstra, Gé A Donker, Wim van der Hoek
We aimed to examine the long-term correlation between influenza vaccination coverage and the incidence of influenza-like illness (ILI) in the total and elderly populations of European countries for which data was available on at least six consecutive influenza seasons. We graphically visualised vaccination coverage and ILI incidence trends and calculated Spearman rank correlation coefficients. Additionally, we fitted a negative binomial regression model to estimate the change in ILI incidence per percentage point change in vaccination coverage...
2016: PloS One
Zhilan Feng, Andrew N Hill, Aaron T Curns, John W Glasser
Among the several means by which heterogeneity can be modeled, Levins' (1969) meta-population approach preserves the most analytical tractability, a virtue to the extent that generality is desirable. When model populations are stratified, contacts among their respective sub-populations must be described. Using a simple meta-population model, Feng et al. (2015) showed that mixing among sub-populations, as well as heterogeneity in characteristics affecting sub-population reproduction numbers, must be considered when evaluating public health interventions to prevent or control infectious disease outbreaks...
September 23, 2016: Mathematical Biosciences
Yotam Levin, Efrat Kochba, Georgi Shukarev, Sarah Rusch, Guillermo Herrera-Taracena, Pierre van Damme
BACKGROUND: Influenza remains a significant problem in elderly despite widespread vaccination coverage. This randomized, phase-I study in elderly compared different strategies of improving vaccine immunogenicity. METHODS: A total of 370 healthy participants (⩾65years) were randomized equally 1:1:1:1:1:1 to six influenza vaccine treatments (approximately 60-63 participants per treatment arm) at day 1 that consisted of three investigational virosomal vaccine formulations at doses of 7...
October 17, 2016: Vaccine
Aye M Moa, David J Muscatello, Robin M Turner, Chandini R MacIntyre
BACKGROUND: Influenza B is characterised by two antigenic lineages: B/Victoria and B/Yamagata. These lineages circulate together with influenza A during influenza seasons, with varying incidence from year to year and by geographic region. OBJECTIVE: To determine the epidemiology of influenza B relative to influenza A in Australia. METHODS: Laboratory-confirmed influenza notifications between 2001 and 2014 in Australia were obtained from the Australian National Notifiable Diseases Surveillance System...
September 21, 2016: Influenza and Other Respiratory Viruses
Justin R Ortiz, Marc Perut, Laure Dumolard, Pushpa Ranjan Wijesinghe, Pernille Jorgensen, Alba Maria Ropero, M Carolina Danovaro-Holliday, James D Heffelfinger, Carol Tevi-Benissan, Nadia A Teleb, Philipp Lambach, Joachim Hombach
INTRODUCTION: The WHO recommends annual influenza vaccination to prevent influenza illness in high-risk groups. Little is known about national influenza immunization policies globally. MATERIAL AND METHODS: The 2014 WHO/UNICEF Joint Reporting Form (JRF) on Immunization was adapted to capture data on influenza immunization policies. We combined this dataset with additional JRF information on new vaccine introductions and strength of immunization programmes, as well as publicly available data on country economic status...
October 26, 2016: Vaccine
Yan-Yang Zhang, Xue-Feng Tang, Chang-Hui Du, Bin-Bing Wang, Zhen-Wang Bi, Bi-Rong Dong
The purpose of this study was to perform a meta-analysis comparing the effectiveness of influenza vaccination alone versus influenza plus pneumococcal dual vaccination for the prevention of pneumonia and mortality in adults ≥ 65 years of age. Medline, Cochrane, CENTRAL, EMBASE, and Google Scholar databases were searched. Inclusion criteria were: 1) Randomized controlled trials (RCTs), 2-arm prospective studies, or retrospective cohort studies; 2) Patients were ≥ 65 years of age with or without chronic respiratory disease; 3) Patients received the influenza vaccine alone or dual pneumococcal and influenza vaccination; 4) Results included incidence of recurrent respiratory tract infections, length of hospital stay, and overall mortality rate...
September 14, 2016: Human Vaccines & Immunotherapeutics
Mustafa Altay, İhsan Ateş, Fatma Aybala Altay, Mustafa Kaplan, Ömer Akça, Adem Özkara
AIMS: This study is performed for inspecting vaccination rates in geriatric patients, negatory effects leading to unvaccination and changes occurring in vaccination rates by patient education. METHODS: This study is planned in a combination of two formats: retrospectively for determining last 5years' vaccination rates of patients and prospectively for determining the change in vaccination rates after patient education. Totally 579 diabetic patients, 206 patients of 65years and over (group 1) and 373 patients under 65years (group 2) were admitted to the study...
October 2016: Diabetes Research and Clinical Practice
George Kassianos, Patricia Blank, Oana Falup-Pecurariu, Ernest Kuchar, Jan Kyncl, Raul Ortiz De Lejarazu, Aneta Nitsch-Osuch, Gerrit A van Essen
Currently there is no influenza vaccination guidance for European general practitioners. Furthermore, although the European Council recommends a target seasonal influenza vaccination rate of 75% in the elderly (65 years and above) and in anyone aged >6 months with a chronic medical condition, there remain wide discrepancies throughout Europe. A harmonised guideline regarding not only vaccination strategy but also for the consistent diagnosis of influenza across Europe is essential to support a common approach for the implementation of seasonal influenza vaccination across Europe...
2016: Drugs in Context
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