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Elderly and influenza

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https://www.readbyqxmd.com/read/28935236/effectiveness-of-influenza-vaccines-in-preventing-severe-influenza-illness-among-adults-a-systematic-review-and-meta-analysis-of-test-negative-design-case-control-studies
#1
REVIEW
Marc Rondy, Nathalie El Omeiri, Mark G Thompson, Alain Levêque, Alain Moren, Sheena Sullivan
OBJECTIVES: Summary evidence of influenza vaccine effectiveness (IVE) against hospitalized influenza is lacking. We conducted a meta-analysis of studies reporting IVE against laboratory-confirmed hospitalized influenza among adults. METHODS: We searched Pubmed (January 2009 to November 2016) for studies that used test-negative design (TND) to enrol patients hospitalized with influenza-associated conditions. Two independent authors selected relevant articles. We calculated pooled IVE against any and (sub)type specific influenza among all adults, and stratified by age group (18-64 and 65 years and above) using random-effects models...
September 18, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28934770/seasonal-influenza-and-vaccination-strategies-is-a-paradigm-shift-needed-a-synopsis-of-the-3rd-new-zealand-influenza-symposium-november-2016
#2
Nadia A Charania, Diana Murfitt, Nikki Turner
Influenza continues to be a global public health problem despite the availability of preventive vaccines and public health vaccination programmes. This paper presents a synopsis of the 3rd New Zealand Influenza Symposium (NZiS) that was hosted by the Immunisation Advisory Centre (IMAC) in November 2016. Experts and service providers convened to discuss current issues in the prevention and management of influenza. One of the key topics discussed was the use of novel vaccines, such as adjuvanted and high-dose vaccines, and antiviral prophylaxis to protect young children and the elderly...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28933281/influenza-virus-small-molecule-therapeutics-and-mechanisms-of-antiviral
#3
Julianna Han, Jasmine Perez, Adam Schafer, Han Cheng, Norton Peet, Lijun Rong, Balaji Manicassamy
Influenza viruses cause severe upper respiratory illness in young children and the elderly during seasonal epidemics. Influenza viruses also have the potential to cause pandemics with significant loss of life in all age groups. Although vaccination is one of the most effective methods to protect against seasonal epidemics, seasonal vaccines afford lowered protection against emerging variant strains and no protection against novel strains. Moreover, the efficacy of influenza virus vaccines is considerably lower in the elderly population...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28931244/the-importance-of-frailty-in-the-assessment-of-influenza-vaccine-effectiveness-against-influenza-related-hospitalization-in-elderly-people
#4
Melissa K Andrew, Vivek Shinde, Lingyun Ye, Todd Hatchette, François Haguinet, Gael Dos Santos, Janet E McElhaney, Ardith Ambrose, Guy Boivin, William Bowie, Ayman Chit, May ElSherif, Karen Green, Scott Halperin, Barbara Ibarguchi, Jennie Johnstone, Kevin Katz, Joanne Langley, Jason Leblanc, Mark Loeb, Donna MacKinnon-Cameron, Anne McCarthy, Allison McGeer, Jeff Powis, David Richardson, Makeda Semret, Grant Stiver, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly A McNeil
Background: Influenza is an important cause of morbidity and mortality among older adults. Even so, effectiveness of influenza vaccine for older adults has been reported to be lower than for younger adults, and the impact of frailty on vaccine effectiveness (VE) and outcomes is uncertain. We aimed to study VE against influenza hospitalization in older adults, focusing on the impact of frailty. Methods: We report VE of trivalent influenza vaccine (TIV) in people ≥65 years of age hospitalized during the 2011-2012 influenza season using a multicenter, prospective, test-negative case-control design...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931164/impact-of-patient-education-on-influenza-vaccine-uptake-among-community-dwelling-elderly-a-randomized-controlled-trial
#5
Ka Chun Leung, Carlo Mui, Wing Yan Chiu, Yuk Yiu Ng, Matthew H Y Chen, Pui Hung Ho, Chun Pong Kwok, Suki S M Lam, Chun Yip Wong, Kit Yee Wong, Herbert H Pang
This randomized controlled trial aimed to test the effectiveness of brief face-to-face patient education in increasing influenza vaccination rate among elderly in the community. Recruitment and intervention were conducted at two general outpatient clinics in Hong Kong. 529 eligible patients were randomly assigned to intervention or control group with 1:1 allocation ratio. Patients in the intervention group received 3-min one-on-one verbal education by medical students and a pamphlet regarding influenza vaccination...
October 1, 2017: Health Education Research
https://www.readbyqxmd.com/read/28929727/-differences-in-influenza-vaccination-coverage-among-subgroups-of-adult-immigrants-residing-in-italy-at-risk-for-complications-2012-2013
#6
Massimo Fabiani, Anteo Di Napoli, Flavia Riccardo, Lidia Gargiulo, Silvia Declich, Alessio Petrelli
OBJECTIVES: to evaluate differences in influenza vaccination coverage (IVC) in immigrants at risk for influenza-related complications, according to their area of origin and length of stay in Italy. DESIGN: cross-sectional survey conducted on the sample of foreign citizens included in the survey on health conditions and use of health services of the Italian resident population (Italian national institute of statistics, 2012-2013). SETTING AND PARTICIPANTS: analysis conducted on 885 foreign adult citizens (≥18 years) at risk for influenza-related complications (elderly residents ≥65 years and residents with specific chronic diseases)...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28928269/perturbed-cd8-t-cell-immunity-across-universal-influenza-epitopes-in-the-elderly
#7
Thi H O Nguyen, Sneha Sant, Nicola L Bird, Emma J Grant, E Bridie Clemens, Marios Koutsakos, Sophie A Valkenburg, Stephanie Gras, Martha Lappas, Anthony Jaworowski, Jane Crowe, Liyen Loh, Katherine Kedzierska
Influenza epidemics lead to severe illness, life-threatening complications, and deaths, especially in the elderly. As CD8(+) T cells are associated with rapid recovery from influenza, we investigated the effects of aging on antigen-specific CD8(+) T cells across the universal influenza epitopes in humans. We show that aging is characterized by altered frequencies in T cell subsets, with naive T cells being partially replaced by activated effector/memory populations. Although we observed no striking differences in TCR signaling capacity, T cells in the elderly had increased expression of transcription factors Eomes and T-bet, and such changes were most apparent in CD8(+) T cells...
September 19, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28923405/positive-mood-on-the-day-of-influenza-vaccination-predicts-vaccine-effectiveness-a-prospective-observational-cohort-study
#8
Kieran Ayling, Lucy Fairclough, Paddy Tighe, Ian Todd, Vanessa Halliday, Jon Garibaldi, Simon Royal, Aljali Hamed, Heather Buchanan, Kavita Vedhara
Influenza vaccination is estimated to only be effective in 17-53% of older adults. Multiple patient behaviors and psychological factors have been shown to act as 'immune modulators' sufficient to influence vaccination outcomes. However, the relative importance of such factors is unknown as they have typically been examined in isolation. The objective of the present study was to explore the effects of multiple behavioral (physical activity, nutrition, sleep) and psychological influences (stress, positive mood, negative mood) on the effectiveness of the immune response to influenza vaccination in the elderly...
September 15, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28922621/a-21-winter-seasons-retrospective-study-of-antibody-response-after-influenza-vaccination-in-elderly-60-85%C3%A2-years-old-and-very-elderly-85%C3%A2-years-old-institutionalized-subjects
#9
Emilia Nunzi, Anna Maria Iorio, Barbara Camilloni
Influenza vaccination is considered the best mean for preventing the higher rates of mortality associated with influenza virus infection in the elderly as compared with younger people. Since the number of very elderly subjects, aged >85 years, is rapidly increasing, and some authors reported increments in influenza-associated mortality with age, the aim of this study was to increase the limited information available on the immunogenicity of the influenza vaccines in this age group. This was a retrospective study which analyzed the antibody response induced by commercially available trivalent inactivated influenza vaccines in 1491 elderly subjects (60-85 years old) and 1139 very elderly subjects (>85 years old) during 21 winter seasons included between 1993-1994 and 2014-2015...
September 18, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28922083/strategies-in-recommending-influenza-vaccination-in-europe-and-us
#10
Caterina Rizzo, Gianni Rezza, Walter Ricciardi
There is potential for influenza vaccine programmes to make a substantial impact on the disease burden. The World Health Organization (WHO) has identified young children, pregnant women, persons with chronic medical conditions, and the elderly as being at risk for severe influenza disease and therefore important groups to be considered for influenza vaccination. Applying the methodology of scoping review of grey and scientific literature we described the European and the US approach to influenza vaccine prevention...
September 18, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28918667/poor-outcomes-among-elderly-patients-hospitalized-for-influenza-like-illness
#11
Mine Durusa Tanriover, Tülay Bagci Bosi, Lale Ozisik, Emre Bilgin, Özlem Güzel Tunçcan, Özge Özgen, Necla Tülek, Metin Özsoy, Hasan Tezer, Tugba Bedir Demirdağ, Ates Kara, Sevgen Tanir Basaranoglu, Kubra Aykac, Aslinur Ozkaya-Parlakay, Belgin Gulhan, Serhat Unal
BACKGROUND AND OBJECTIVE: Global Influenza Hospital Surveillance Network is a worldwide initiative that aims to document the burden of influenza infections among acute admissions and the vaccine effectiveness in particular countries. As a partner of this platform, we aimed to determine the frequency of influenza infections among acute admissions with influenza like illness and the outcomes of the enrolled patients during the 2015-2016 influenza season in selected hospitals in Turkey. PATIENTS AND METHODS: The investigators screened the hospital admission registries, chart review or available records, and screened all patients hospitalized in the previous 24-48 hours or overnight in the predefined wards or emergency room...
September 18, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28913991/seasonal-cycle-and-relationship-of-seasonal-rhino-and-influenza-virus-epidemics-with-episodes-of-asthma-exacerbation-in-different-age-groups
#12
Seung Won Lee, Shinhae Lee, Youn Ho Sheen, Eun Kyo Ha, Sun Hee Choi, Min Suk Yang, Sohyun Hwang, Sung Soon Kim, Jang Hoon Choi, Man Yong Han
PURPOSE: Seasonal variations in asthma exacerbation (AE) are associated with respiratory virus outbreaks and the return of children to school after vacation. This study aims to elucidate the period, phase, and amplitude of seasonal cycles of AE in 5 different age groups with regard to rhino- and influenza virus epidemics in Korea. METHODS: The number of daily emergency department (ED) visits for AE in all age groups of Korea and the nationwide weekly incidence of rhino- and influenza virus, were obtained for 2008-2012...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28904202/discrete-dynamical-modeling-of-influenza-infection-suggests-age-dependent-differences-in-immunity
#13
Ericka Keef, Li Ang Zhang, David Swigon, Alisa Urbano, G Bard Ermentrout, Michael Matuszewski, Franklin R Toapanta, Ted M Ross, Robert S Parker, Gilles Clermont
Immunosenescence, an age-related decline in immune function, is a major contributor to morbidity and mortality in the elderly. Older hosts exhibit delayed onset of immunity and prolonged inflammation after an infection, leading to excess damage and greater likelihood of death. Our study applies a rule-based model to infer which components of immune response are most changed in an aged host. Two groups of BALB/c mice (age 12-16 wks and 72-76 wks) were infected at 2 inocula: a survivable 50 PFU dose and a lethal 500 PFU dose...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28899815/blockage-of-regulatory-t-cells-augments-induction-of-protective-immune-responses-by-influenza-virus-like-particles-in-aged-mice
#14
Zhiyuan Wen, Xi Wang, Ke Dong, Huizhong Zhang, Zhigao Bu, Ling Ye, Chinglai Yang
Elderly humans over 65 years old are at great risk to pathogenesis by influenza virus infection. However, although influenza vaccines provide effective protection in healthy young adults, protection of elderly adults is substantially lower even with a good match between the vaccine and the circulating influenza virus. To gain insight of the underlying mechanism for the reduced immunogenicity of influenza vaccines in the aged population, we investigated immunogenicity of influenza virus-like particle vaccines in aged mice, which represent a useful model for studying aging associated impairment in immune responses...
September 9, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28893473/data-and-product-needs-for-influenza-immunization-programs-in-low-and-middle-income-countries-rationale-and-main-conclusions-of-the-who-preferred-product-characteristics-for-next-generation-influenza-vaccines
#15
Kathleen M Neuzil, Joseph S Bresee, Fernando de la Hoz, Kari Johansen, Ruth A Karron, Anand Krishnan, Shabir A Madhi, Punam Mangtani, David J Spiro, Justin R Ortiz
In 2017, WHO convened a working group of global experts to develop the Preferred Product Characteristics (PPC) for Next-Generation Influenza Vaccines. PPCs are intended to encourage innovation in vaccine development. They describe WHO preferences for parameters of vaccines, in particular their indications, target groups, implementation strategies, and clinical data needed for assessment of safety and efficacy. PPCs are shaped by the global unmet public health need in a priority disease area for which WHO encourages vaccine development...
September 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28882967/influenza-among-breast-cancer-survivors-in-south-korea-a-nationwide-population-based-study
#16
Jaesung Heo, Mison Chun, Young-Taek Oh, O Kyu Noh, Logyoung Kim
BACKGROUND/AIM: In this study, we analyzed the prevalence of influenza disease in breast cancer survivors using claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea. PATIENTS AND METHODS: We defined influenza among a nationwide cohort of 87,843 patients who were diagnosed with breast cancer and underwent surgery from January 1, 2010 to December 31, 2014, based on HIRA claim data. Descriptive statistics were calculated to estimate the frequency of influenza disease using diagnostic code and utilization pattern at medical institutions...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882149/cost-effectiveness-analysis-of-quadrivalent-seasonal-influenza-vaccines-in-england
#17
Dominic Thorrington, Edwin van Leeuwen, Mary Ramsay, Richard Pebody, Marc Baguelin
BACKGROUND: As part of the national seasonal influenza vaccination programme in England and Wales, children receive a quadrivalent vaccine offering protection against two influenza A strains and two influenza B strains. Healthy children receive a quadrivalent live attenuated influenza vaccine (QLAIV), whilst children with contraindications receive the quadrivalent inactivated influenza vaccine (QIIV). Individuals aged younger than 65 years in the clinical risk populations and elderly individuals aged 65+ years receive either a trivalent inactivated influenza vaccine (TIIV) offering protection from two A strains and one B strain or the QIIV at the choice of their general practitioner...
September 8, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28869984/influenza
#18
REVIEW
Timothy M Uyeki
Influenza is an acute viral respiratory disease that affects persons of all ages and is associated with millions of medical visits, hundreds of thousands of hospitalizations, and thousands of deaths during annual winter epidemics of variable severity in the United States. Elderly persons have the highest influenza-associated hospitalization and mortality rates. The primary method of prevention is annual vaccination. Early antiviral treatment has the greatest clinical benefit; otherwise, management includes adherence to recommended infection prevention and control measures as well as supportive care of complications...
September 5, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28857349/factors-that-influence-influenza-vaccination-rates-among-the-elderly-nurses-perspectives
#19
Moriah Ellen
AIMS: To explore which factors nurses perceive to help and hinder influenza vaccination rates among the elderly. BACKGROUND: Influenza-related illnesses and deaths have disproportionately high prevalence among the elderly. Vaccination is an effective tool to prevent complications. METHODS: Semistructured interviews were conducted with nurses focusing on barriers, facilitators and health care providers' roles in influencing patients to be vaccinated...
August 30, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28857047/the-effectiveness-of-influenza-vaccination-in-preventing-hospitalisations-of-elderly-individuals-in-two-influenza-seasons-a-multicentre-case-control-study-spain-2013-14-and-2014-15
#20
Angela Domínguez, Núria Soldevila, Diana Toledo, Pere Godoy, Elena Espejo, Maria Amelia Fernandez, José María Mayoral, Jesús Castilla, Mikel Egurrola, Sonia Tamames, Jenaro Astray, María Morales-Suárez-Varela
Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression...
August 24, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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