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Elderly and influenza

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https://www.readbyqxmd.com/read/28198157/a-review-of-the-antiviral-properties-of-black-elder-sambucus-nigra-l-products
#1
REVIEW
Randall S Porter, Robert F Bode
Black elder (Sambucus nigra L.) has a long ethnobotanical history across many disparate cultures as a treatment for viral infection and is currently one of the most-used medicinal plants worldwide. Until recently, however, substantial scientific research concerning its antiviral properties has been lacking. Here, we evaluate the state of current scientific research concerning the use of elderberry extract and related products as antivirals, particularly in the treatment of influenza, as well as their safety and health impacts as dietary supplements...
February 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28187750/study-on-age-dependent-pre-existing-2009-pandemic-influenza-virus-t-and-b-cell-responses-from-chinese-population
#2
Jin Lv, Zhen-Yong Ren, Ying-Ying Zhang, Yun-E Liu, Jun Gao, Kun Yao, Dan Feng, Zhen-Yuan Li, Xin Feng, Yun-Xi Liu, Na Jia
BACKGROUND: The outbreak of the 2009 H1N1 influenza pandemic (H1N1pdm) affected thousands of people in Mexico and the United States, and spread rapidly throughout the world from April 2009 to July 2010. To explore the age-specific prevalence of seroprotection against H1N1pdm infection, we estimated pre-existing humoral and cellular immunities of residents in Northern China against H1N1pdm and seasonal H1N1 virus in an age-dependent manner. METHODS: Anonymous serum samples were collected from 1425 to 1434 adult healthy individuals before and after the pandemic outbreak, and then grouped by birth year 1913-1990...
February 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28185822/barriers-and-strategies-to-improve-influenza-vaccination-in-pakistan
#3
Muhammad Junaid Farrukh, Long Chiau Ming, Syed Tabish Razi Zaidi, Tahir Mehmood Khan
Influenza vaccination is strongly recommended by World Health Organisation on a yearly basis. The rate of immunization in Pakistan is suboptimal. High cost, traditional norms, customs and low levels of education in Pakistan are preventing people from getting vaccinated. It is timely to include influenza vaccination in the expanded programme on immunization (EPI), which is a disease prevention programme aiming to eradicate preventable diseases through subsidized or free immunization. The Ministry of National Health Services, Regulation and Coordination, Government of Pakistan should launch a national influenza vaccine policy in view of this current situation and oversee its implementation...
February 6, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28168172/comparison-of-immunogenicity-and-safety-of-an-influenza-vaccine-administered-concomitantly-with-a-13-valent-pneumococcal-conjugate-vaccine-or-23-valent-polysaccharide-pneumococcal-vaccine-in-the-elderly
#4
Yu Bin Seo, Won Suk Choi, Jacob Lee, Joon Young Song, Hee Jin Cheong, Woo Joo Kim
PURPOSE: Previous studies have demonstrated the immunogenicity and safety of the co-administration of the trivalent inactivated influenza vaccine (IIV3) with the polysaccharide pneumococcal vaccine (PPV) or pneumococcal conjugate vaccine (PCV). However, there is no direct comparison study that evaluates the immunogenicity and safety of IIV3 given concomitantly with PCV13 or PPV23 in the elderly. MATERIALS AND METHODS: During the 2012-2013 influenza vaccination period, 224 healthy elderly volunteers aged 65 years and older randomly received IIV3 given concomitantly with either PCV13 (PCV13+IIV3) or PPV23 (PPV23+IIV3) in a 1:1 ratio...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28148221/motivations-for-non-participation-in-population-based-health-studies-among-the-elderly-comparison-of-participants-and-nonparticipants-of-a-prospective-study-on-influenza-vaccination
#5
Manas K Akmatov, Leonhard Jentsch, Peggy Riese, Marcus May, Malik W Ahmed, Damaris Werner, Anja Rösel, Jana Prokein, Inga Bernemann, Norman Klopp, Blair Prochnow, Thomas Illig, Christoph Schindler, Carlos A Guzman, Frank Pessler
BACKGROUND: Participation in epidemiological studies has strongly declined in recent years. We examined the reasons for (non)participation in population-based health studies among participants and nonparticipants of a prospective study on influenza vaccination among the elderly. METHODS: Males and females between 65 and 80 years of age (N = 5582) were randomly selected from the residents' registration office in Hannover, Germany, and were invited to participate in a study featuring vaccination with a seasonal adjuvanted influenza vaccine (Fluad™, Novartis) including five follow-up visits (day 0, 1/3, 7, 21, 70 with respect to vaccination)...
February 2, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28134768/unexpectedly-higher-morbidity-and-mortality-of-hospitalized-elderly-patients-associated-with-rhinovirus-compared-with-influenza-virus-respiratory-tract-infection
#6
Ivan F N Hung, Anna Jinxia Zhang, Kelvin K W To, Jasper F W Chan, Shawn H S Zhu, Ricky Zhang, Tuen-Ching Chan, Kwok-Hung Chan, Kwok-Yung Yuen
Rhinovirus is a common cause of upper and lower respiratory tract infections in adults, especially among the elderly and immunocompromised. Nevertheless, its clinical characteristics and mortality risks have not been well described. A retrospective analysis on a prospective cohort was conducted in a single teaching hospital center over a one-year period. We compared adult patients hospitalized for pneumonia caused by rhinovirus infection with those hospitalized for influenza infection during the same period...
January 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28118319/no-more-winter-crisis-forecasting-daily-bed-requirements-for-emergency-department-admissions-to-hospital
#7
Mathias Wargon, Dominique Brun-Ney, Laure Beaujouan, Enrique Casalino
STUDY HYPOTHESIS: We hypothesized that age, calendar variables, and clinical influenza epidemics may have an impact on the number of daily through-emergency department (ED) hospitalizations. The aim of our study was to elaborate a pragmatic tool to predict the daily number of through-ED hospitalizations. METHODS: We carried out a prospective-observational study including data from 18 ED located in the Paris metropolitan area. Daily through-ED hospitalizations numbers from 2007 to 2010 were modelized to forecast the year 2011 using a general linear model by age groups (<75-years; ≥75-years) using calendar variables and influenza epidemics as explanatory variables...
January 25, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28118092/public-health-impact-and-economic-benefits-of-quadrivalent-influenza-vaccine-in-latin-america
#8
Aurélien Jamotte, Emilie Clay, Bérengère Macabeo, Andrès Caicedo, Juan Guillermo Lopez, Lucia Bricks, Martín Romero Prada, Rubén Marrugo, Pamela Alfonso, Brechla Moreno Arévalo, Danilo Franco, Lourdes Garcia Diaz, Yadira Isaza de Molto
Annual trivalent influenza vaccines (TIV) containing 2 A strains and one B lineage have been recommended for the prevention of influenza in most of Latin American countries. However, the circulation of 2 B lineages (Victoria and Yamagata) and difficulties in predicting the predominating lineage have led to the development of quadrivalent influenza vaccines (QIV), including both B lineages. Thus, the objective was to estimate the public health impact and influenza-related costs if QIV would have been used instead of TIV in 3 Latin American countries...
January 24, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28096374/phylogenetic-analysis-of-the-human-antibody-repertoire-reveals-quantitative-signatures-of-immune-senescence-and-aging
#9
Charles F A de Bourcy, Cesar J Lopez Angel, Christopher Vollmers, Cornelia L Dekker, Mark M Davis, Stephen R Quake
The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and elderly individuals before and after influenza vaccination. We determined that BCR repertoires become increasingly specialized over a span of decades, but less plastic...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28094076/influenza-vaccination-in-older-people-with-diabetes-and-their-household-contacts
#10
Lin Yang, Hairong Nan, Jun Liang, Yin Hang Chan, Laam Chan, Rita Wing Man Sum, Yee Mei Kwan, Feifei Zhou, Huaiqing Meng, Lorna Kwai Ping Suen
BACKGROUND: People with diabetes are at a higher risk of influenza infections and severe complications. The vaccination of close contacts could offer indirect protection to people with diabetes; this is known as "herd immunity." The aim of this study is to investigate the vaccination rates of people with diabetes and their household contacts in Hong Kong. RESEARCH DESIGN AND METHODS: Face-to-face interviews with 158 patients diagnosed with Type 2 diabetes and aged ⩾65years were conducted in clinics...
January 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28065476/back-to-the-future-immunization-with-m-001-prior-to-trivalent-influenza-vaccine-in-2011-12-enhanced-protective-immune-responses-against-2014-15-epidemic-strain
#11
George H Lowell, Sagit Ziv, Svetlana Bruzil, Ron Babecoff, Tamar Ben-Yedidia
We previously reported a 2011/12 study in elderly showing that immunization with the universal influenza vaccine candidate, M-001, three weeks before administering trivalent influenza vaccine (TIV) enhanced seroconversion of Hemagglutination Inhibition (HAI) antibodies against known influenza vaccine strains circulating at that time. We now report that those subjects primed with M-001 prior to TIV in 2011 also showed, in their 2011 sera, significantly more HAI antibodies with improved seroprotection and seroconversion against strain A/Switzerland/9715293/2013(H3N2-like) that caused the 2014/15 influenza epidemic and that wasn't known to circulate in 2011/12...
February 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28062184/c-jun-n-terminal-kinase-activity-is-required-for-efficient-respiratory-syncytial-virus-production
#12
Leon Caly, Hong-Mei Li, Marie A Bogoyevitch, David A Jans
Respiratory syncytial virus (RSV) is a major cause of respiratory infections in infants and the elderly, leading to more deaths than influenza each year worldwide. With no RSV antiviral or efficacious vaccine currently available, improved understanding of the host-RSV interaction is urgently required. Here we examine the contribution to RSV infection of the host stress-regulated c-Jun N-terminal kinase (JNK), for the first time. Peak JNK1/2 phosphoactivation is observed at ∼24 h post-infection, correlating with the time of virus assembly...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28054599/estimating-risks-of-inapparent-avian-exposure-for-human-infection-avian-influenza-virus-a-h7n9-in-zhejiang-province-china
#13
Erjia Ge, Renjie Zhang, Dengkui Li, Xiaolin Wei, Xiaomeng Wang, Poh-Chin Lai
Inapparent avian exposure was suspected for the sporadic infection of avian influenza A(H7N9) occurring in China. This type of exposure is usually unnoticed and difficult to model and measure. Infected poultry with avian influenza H7N9 virus typically remains asymptomatic, which may facilitate infection through inapparent poultry/bird exposure, especially in a country with widespread practice of backyard poultry. The present study proposed a novel approach that integrated ecological and case-control methods to quantify the risk of inapparent avian exposure on human H7N9 infection...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28049046/the-business-cycle-and-mortality-urban-versus-rural-counties
#14
Sediq Sameem, Kevin Sylwester
Many studies have found that mortality declines during recessions, but do such results remain consistent in both urban and rural settings? To help uncover explanations for such a pro-cyclical nature of mortality, the present study revisits this topic but allows for associations between unemployment and mortality to differ between urban and rural areas. Using a total of 66 863 observations across 3066 counties of the U.S. from 1990 to 2013, we allow the coefficient on unemployment to differ between urban and rural counties...
December 23, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28043227/influenza-epidemiology-in-patients-admitted-to-sentinel-australian-hospitals-in-2015-the-influenza-complications-alert-network
#15
Allen C Cheng, Mark Holmes, Dominic E Dwyer, Louis B Irving, Tony M Korman, Sanjaya Senenayake, Kristine K Macartney, Christopher C Blyth, Simon Brown, Grant Waterer, Robert Hewer, N Deborah Friedman, Peter A Wark, Graham Simpson, John Upham, Simon D Bowler, Albert Lessing, Tom Kotsimbos, Paul M Kelly
The Influenza Complications Alert Network (FluCAN) is a sentinel hospital-based surveillance program that operates at sites in all states and territories in Australia. This report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2015 influenza season. In this observational study, cases were defined as patients admitted to one of the sentinel hospitals with an acute respiratory illness with influenza confirmed by nucleic acid detection. During the period 1 April to 30 October 2015 (the 2015 influenza season), 2,070 patients were admitted with confirmed influenza to one of 17 FluCAN sentinel hospitals...
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28031209/factors-associated-with-influenza-vaccination-coverage-among-the-elderly-in-south-korea-the-fourth-korean-national-health-and-nutrition-examination-survey-knhanes-iv
#16
David Soonil Kwon, Kyuwoong Kim, Sang Min Park
OBJECTIVE: The annual outbreak of influenza is one of the major causes of morbidity and mortality among the elderly population around the world. While there is an annual vaccine available to prevent or reduce the incidence of disease, not all older people in Korea choose to be vaccinated. There have been few previous studies to examine the factors influencing influenza vaccination in Korea. Thus, this study identifies nationwide factors that affect influenza vaccination rates in elderly Koreans...
December 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/28024956/effectiveness-of-mf59-adjuvanted-seasonal-influenza-vaccine-in-the-elderly-a-systematic-review-and-meta-analysis
#17
REVIEW
Alexander Domnich, Lucia Arata, Daniela Amicizia, Joan Puig-Barberà, Roberto Gasparini, Donatella Panatto
BACKGROUND: In the elderly, traditional influenza inactivated vaccines are often only modestly immunogenic, owing to immunosenescence. Given that adjuvantation is a means of enhancing the immune response, the trivalent inactivated vaccine adjuvanted with MF59 (MF59-TIV) was specifically designed to overcome this problem. Considering that, for ethical reasons, the absolute effectiveness of an influenza vaccine in the elderly cannot be demonstrated in placebo-controlled studies, the present study aimed to assess the effectiveness of MF59-TIV in preventing influenza-related outcomes in the elderly...
December 23, 2016: Vaccine
https://www.readbyqxmd.com/read/27960210/community-acquired-pneumonia-in-latin-america
#18
Hernán A Iannella, Carlos M Luna
Community-acquired pneumonia (CAP) is associated with significant morbidity and mortality in Latin America and the Caribbean (LAC) region. Poverty, socioeconomic factors, and malnutrition influence the incidence and outcome of CAP in LAC. In LAC, Streptococcus pneumoniae is the most frequent microorganism responsible for CAP, (incidence: 24-78%); the incidence of atypical microorganisms is similar to other regions of the world. Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a growing problem in the LAC region, with the Caribbean being the second most affected area worldwide after Sub-Saharan Africa...
December 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27943624/temporal-cross-correlation-between-influenza-like-illnesses-and-invasive-pneumococcal-disease-in-the-netherlands
#19
Wilke Hendriks, Hendriek Boshuizen, Arnold Dekkers, Mirjam Knol, Ge A Donker, Arie van der Ende, Hester Korthals Altes
BACKGROUND: While the burden of community-acquired pneumonia and invasive pneumococcal disease (IPD) is still considerable, there is little insight in the factors contributing to disease. Previous research on the lagged relationship between respiratory viruses and pneumococcal disease incidence is inconclusive, and studies correcting for temporal autocorrelation are lacking. OBJECTIVES: To investigate the temporal relation between influenza-like illnesses (ILI) and IPD, correcting for temporal autocorrelation...
March 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/27943329/viral-pathogens-among-elderly-people-with-acute-respiratory-infections-in-shanghai-china-preliminary-results-from-a-laboratory-based-surveillance-2012-2015
#20
Chuchu Ye, Weiping Zhu, Jianxing Yu, Zhongjie Li, Yifei Fu, Yajia Lan, Shengjie Lai, Yuanping Wang, Lifeng Pan, Qiao Sun, Genming Zhao
Acute respiratory infections (ARIs), with viral pathogens as the major contributors, are the most common illnesses worldwide, and increase the morbidity and mortality among the elderly population. The clinical and pathological features of elderly people with ARIs need to be identified for disease intervention. From January 1(st) , 2012 through December 31(st) , 2015, respiratory specimens from patients above 60 years old with ARIs were collected from the outpatient and inpatient settings of six sentinel hospitals in Pudong New Area...
December 12, 2016: Journal of Medical Virology
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