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Elderly and influenza

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https://www.readbyqxmd.com/read/28636411/asthma-and-influenza-vaccination-in-elderly-hospitalized-patients-matched-case-control-study-in-spain
#1
María Morales Suárez-Varela, Agustin Llopis, Estrella Fernandez-Fabrellas, Francisco Sanz, M Jose Perez-Lozano, Vicente Martin, Jenaro Astray, Jesús Castilla, Mikel Egurrola, Luis Force, Diana Toledo, Àngela Domínguez
OBJECTIVES: Influenza infection is an exacerbating factor for asthma, and its prevention is critical in managing asthmatic patients. We investigated the effect of influenza vaccination on asthmatic and non-asthmatic patients hospitalized with laboratory-confirmed influenza in Spain. METHODS: We made a matched case-control study to assess the frequency of hospitalization for influenza in people aged ≥65 years. Hospitalized patients with unplanned hospital admissions were recruited from 20 hospitals representing seven Spanish regions...
June 21, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28632298/patient-med-tbe-f%C3%A3-rb%C3%A3-ttrades-snabbt-vid-behandling-med-kortison-evidens-saknas-dock-f%C3%A3-r-v%C3%A3-rdet-av-immunmodulerande-terapi
#2
Carl Wengse, Jesper Ericsson, Susanna Hallberg, Johan Ursing
Rapid improvement of tick-borne encephalitis after treatment with corticosteroids Tick-borne encephalitis (TBE) is a viral disease transmitted by ticks. The virus is divided into three subtypes named Western, Siberian and Far Eastern TBE virus (TBEV). Western TBEV is endemic in parts of Europe and Sweden and typically causes a biphasic illness with influenza-like symptoms followed by neurological symptoms ranging from mild meningitis to severe meningoencephalitis and death. Despite an effective vaccine, TBE is increasing in Sweden and Europe...
June 16, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28632192/coverage-and-influencing-determinants-of-influenza-vaccination-in-elderly-patients-in-a-country-with-a-poor-vaccination-implementation
#3
Maria Ganczak, Karolina Gil, Marcin Korzeń, Marta Bażydło
The seasonal influenza vaccination uptake of the elderly in Poland is one of the lowest in Europe. Objective: to assess the vaccination coverage and influencing determinants in patients ≥65 years of age. METHODS: A cross-sectional study was conducted (November 2015-April 2016) among consecutive patients admitted to a municipal hospital located in the city of Szczecin, North-west Poland. Patients completed researcher-administered, anonymous questionnaires on socio- demographic data/factors related to the vaccination...
June 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28628462/attributable-fraction-of-influenza-virus-detection-to-mild-and-severe-respiratory-illnesses-in-hiv-infected-and-hiv-uninfected-patients-south-africa-2012-2016
#4
Stefano Tempia, Sibongile Walaza, Jocelyn Moyes, Adam L Cohen, Claire von Mollendorf, Meredith L McMorrow, Florette K Treurnicht, Marietjie Venter, Marthi Pretorius, Orienka Hellferscee, Nicole Wolter, Anne von Gottberg, Athermon Nguweneza, Johanna M McAnerney, Halima Dawood, Ebrahim Variava, Shabir A Madhi, Cheryl Cohen
The attributable fraction (AF) of influenza virus detection to illness has not been described for patients in different age groups or with different HIV infection statuses. We compared the age group-specific prevalence of influenza virus infection among patients with influenza-like illness (ILI) or severe acute or chronic respiratory illness (SARI and SCRI, respectively) with that among controls, stratified by HIV serostatus. The overall AF for influenza virus detection to illness was 92.6% for ILI, 87.4% for SARI, and 86...
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28601824/a-systematic-review-of-economic-evaluations-of-seasonal-influenza-vaccination-for-the-elderly-population-in-the-european-union
#5
Gemma E Shields, Jamie Elvidge, Linda M Davies
OBJECTIVES: The Council of the European Union (EU) has recommended that action should be taken to increase influenza vaccination in the elderly population. The aims were to systematically review and critically appraise economic evaluations for influenza vaccination in the elderly population in the EU. METHODS: Electronic searches of the NHS Economic Evaluation, Health Technology Assessment, MEDLINE and Embase databases were run to identify full economic evaluations...
June 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28576489/mitochondrial-protein-p32-hapb1-gc1qr-c1qbp-is-required-for-efficient-respiratory-syncytial-virus-production
#6
MengJie Hu, Hong-Mei Li, Marie A Bogoyevitch, David A Jans
Respiratory syncytial virus (RSV) is a major cause of respiratory infections in infants and the elderly, leading to more deaths than influenza each year, but there is no antiviral or efficacious vaccine currently available. Here we examine the role in infection of the host mitochondrial protein p32 (HABP/gC1qR/C1qbp) for the first time. RSV replication as well as infectious virus production was significantly reduced by p32 siRNA knockdown, consistent with an important role for p32 in RSV infection. p32 showed distinct mitochondrial localization throughout RSV infection, but immunostaining and high resolution confocal imaging for p32 as well as MitoTracker Red and cytochrome c, revealed clear changes in mitochondrial organization in RSV infection, with perinuclear mitochondrial compaction and asymmetric distribution at 8 and 18 h post-infection, respectively...
May 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28575073/a-comprehensive-retrospective-study-of-the-seroprevalence-of-h9n2-avian-influenza-viruses-in-occupationally-exposed-populations-in-china
#7
Xin Li, Bai Tian, Zhou Jianfang, Chen Yongkun, Li Xiaodan, Zhu Wenfei, Li Yan, Tang Jing, Guo Junfeng, Chen Tao, Gao Rongbao, Wang Dayan, Yuelong Shu
The H9N2 avian influenza virus circulates worldwide, predominantly in poultry. Its increasing infectivity and adaptation in poultry and mammals have enhanced the possibility of human infection. However, H9N2 human cases are difficult to detect due to their mild clinical symptoms. Serological study is valuable for risk assessment. A total of 15,700 serum samples were collected from occupationally exposed populations in 22 provinces of China and tested using hemagglutination inhibition (HI) and microneutralization (MN) assays...
2017: PloS One
https://www.readbyqxmd.com/read/28562551/final-diagnoses-and-probability-of-new-reason-for-encounter-at-an-urban-clinic-in-japan-a-4-year-observational-study
#8
Motoharu Fukushi, Yukishige Ishibashi, Naoki Nago
Past clinical data are not currently used to calculate pretest probabilities, as they have not been put into a database in clinical settings. This observational study was designed to determine the initial reasons for utilizing home visits or visits to an outpatient urban clinic in Japan.All family medical clinic outpatients and patients visited by the clinic (total = 11,688) over 1460 days were enrolled.We used a Bayes theorem-based clinical decision support system to analyze codes for initial reason-for-encounter (examination and final diagnosis: pretest probability) and final diagnosis of patients with fever (conditional pretest probability)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28542417/interim-estimates-of-the-effectiveness-of-the-influenza-vaccine-against-a-h3n2-influenza-in-adults-in-south-korea-2016-2017-season
#9
Ji Yun Noh, Sooyeon Lim, Joon Young Song, Won Suk Choi, Hye Won Jeong, Jung Yeon Heo, Jacob Lee, Yu Bin Seo, Jin-Soo Lee, Seong Heon Wie, Young Keun Kim, Kyung Hwa Park, Sook-In Jung, Shin Woo Kim, Sun Hee Lee, Han Sol Lee, Young Hoon Yoon, Hee Jin Cheong, Woo Joo Kim
In the 2016-2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1% (95% confidence interval [CI], -147...
2017: PloS One
https://www.readbyqxmd.com/read/28538182/targeting-metabolic-reprogramming-by-influenza-infection-for-therapeutic-intervention
#10
Heather S Smallwood, Susu Duan, Marie Morfouace, Svetlana Rezinciuc, Barry L Shulkin, Anang Shelat, Erika E Zink, Sandra Milasta, Resha Bajracharya, Ajayi J Oluwaseum, Martine F Roussel, Douglas R Green, Ljiljana Pasa-Tolic, Paul G Thomas
Influenza is a worldwide health and financial burden posing a significant risk to the immune-compromised, obese, diabetic, elderly, and pediatric populations. We identified increases in glucose metabolism in the lungs of pediatric patients infected with respiratory pathogens. Using quantitative mass spectrometry, we found metabolic changes occurring after influenza infection in primary human respiratory cells and validated infection-associated increases in c-Myc, glycolysis, and glutaminolysis. We confirmed these findings with a metabolic drug screen that identified the PI3K/mTOR inhibitor BEZ235 as a regulator of infectious virus production...
May 23, 2017: Cell Reports
https://www.readbyqxmd.com/read/28521688/vasculitis-following-influenza-vaccination-a-review-of-the-literature
#11
Toru Watanabe
BACKGROUND: Influenza vaccine is safe and effective for the general population as well as for patients with autoimmune diseases. However, although rare, vasculitis has been reported as an adverse event following influenza vaccination. OBJECT: The aims of this literature review were to identify patients who developed vasculitis following influenza vaccination and to clarify the clinical manifestations of vasculitis in these patients. METHODS: Using the PubMed database and search engine, we performed a search of the English-language literature by combining the term influenza vaccination with each term for a specific form of vasculitis from January 1966 through April 2016...
May 17, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28514204/factors-influencing-influenza-vaccination-among-south-korean-adult-asthma-patients-a-nationwide-population-based-cross-sectional-study
#12
Jae Ho Chung, Tae Ho Kim, Chang Hoon Han
BACKGROUND: It is important to identify factors associated with influenza vaccination. This study was performed to investigate factors associated with vaccination coverage among asthma patients in Korea. METHODS: Data were obtained from 229,121 participants (5,989 with asthma and 223,132 without asthma) in the 2010 Korean Community Health Survey. The demographic characteristics and socioeconomic status of respondents with and without asthma were compared. Univariate and multiple logistic regression analyses were used to evaluate socioeconomic status and other demographic variables potentially related to influenza vaccination in asthma patients...
May 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28481673/influenza-vaccine-effectiveness-among-high-risk-groups-a-systematic-literature-review-and-meta-analysis-of-case-control-and-cohort-studies
#13
Vincenzo Restivo, Claudio Costantino, Stefania Bono, Marialuisa Maniglia, Valentina Marchese, Gianmarco Ventura, Alessandra Casuccio, Fabio Tramuto, Francesco Vitale
Vaccination represents the most effective intervention to prevent infection, hospitalization and mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine effectiveness (VE) on influenza visits and hospitalizations of case-control and cohort studies among high-risk groups. A systematic literature review including original articles published between 2007 and 2016, using a protocol registered on Prospero with No. 42017054854, and a meta-analysis were conducted. For 3 high-risk groups (subjects with underlying health conditions, pregnant women and health care workers) only a qualitative evaluation was performed...
May 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28475770/systematic-review-and-meta-analysis-of-indirect-protection-afforded-by-vaccinating-children-against-seasonal-influenza-implications-for-policy
#14
J Kevin Yin, Anita E Heywood, Melina Georgousakis, Catherine King, Clayton Chiu, David Isaacs, Kristine K Macartney
BACKGROUND: Universal childhood vaccination is a potential solution to reduce seasonal influenza burden. METHODS: We reviewed systematically the literature on 'herd'/indirect protection from vaccinating children aged 0·5-<18 years against influenza. RESULTS: Of 30 studies included, 14 (including one cluster-randomized-controlled trial [cRCT]) used live-attenuated-influenza-vaccine, 11 (seven cRCTs) used inactivated-influenza-vaccine, and five (one cRCT) compared both vaccine types...
May 5, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28452003/the-public-health-impact-of-the-so-called-fluad-effect-on-the-2014-2015-influenza-vaccination-campaign-in-italy-ethical-implications-for-health-care-workers-and-health-communication-practitioners
#15
Roberto Rosselli, Mariano Martini, Nicola Luigi Bragazzi, Abdulla Watad
Seasonal influenza, causing complications, hospitalizations and deaths, generates a serious socio-economic burden, especially among elderly and high-risk subjects, as well as among adult individuals. Despite the availability and active free-of charge offer of influenza vaccines, vaccine coverage rates remain low and far from the target established by the Ministry of Health. Notwithstanding their effectiveness, vaccines are victims of prejudices and false myths, that contribute to the increasing phenomenon of vaccine hesitancy and loss of confidence...
April 28, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28441935/direct-and-indirect-effects-of-influenza-vaccination
#16
Martin Eichner, Markus Schwehm, Linda Eichner, Laetitia Gerlier
BACKGROUND: After vaccination, vaccinees acquire some protection against infection and/or disease. Vaccination, therefore, reduces the number of infections in the population. Due to this herd protection, not everybody needs to be vaccinated to prevent infections from spreading. METHODS: We quantify direct and indirect effects of influenza vaccination examining the standard Susceptible-Infected-Recovered (SIR) and Susceptible-Infected-Recovered-Susceptible (SIRS) model as well as simulation results of a sophisticated simulation tool which allows for seasonal transmission of four influenza strains in a population with realistic demography and age-dependent contact patterns...
April 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28432994/assessment-of-temporal-variation-for-the-risk-of-particulate-matters-on-asthma-hospitalization
#17
Hyomi Kim, Honghyok Kim, Yoon-Hyung Park, Jong-Tae Lee
Increased ambient concentration of particulate matters are considered as one of major causes for increased prevalence or exacerbation of asthma or asthma like symptoms. Recently, possible temporal variation in risks of PM on mortality has been suggested. We investigated short-term effect of both PM10 and PM2.5 on asthma hospitalization, and assessed temporal variation of PM risks in Seoul, Korea, 2003-2011. Generalized additive model was used to estimate PM risks on asthma hospitalization with consideration by long-term trend, influenza epidemic, day of week, meteorological factors...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28431815/efficacy-and-safety-of-high-dose-influenza-vaccine-in-elderly-adults-a-systematic-review-and-meta-analysis
#18
REVIEW
Krista Wilkinson, Yichun Wei, Andrea Szwajcer, Rasheda Rabbani, Ryan Zarychanski, Ahmed M Abou-Setta, Salaheddin M Mahmud
INTRODUCTION: Older adults are prioritized for influenza vaccination but also have lowered antibody responses to the vaccine. Higher-doses of influenza antigen may increase immune response and thus be more effective. Our objectives were to compare the efficacy and safety of the high-dose influenza vaccine to the standard-dose influenza vaccine in the elderly (age>65). METHODS: Data sources: Randomized trials (RCTs) from Medline (Ovid), EMBASE (Ovid), Cochrane Library (Wiley), ClinicalTrials...
April 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28428558/a-joint-analysis-of-influenza-associated-hospitalizations-and-mortality-in-hong-kong-1998-2013
#19
Peng Wu, Anne M Presanis, Helen S Bond, Eric H Y Lau, Vicky J Fang, Benjamin J Cowling
Influenza viruses may cause severe human infections leading to hospitalization or death. Linear regression models were fitted to population-based data on hospitalizations and deaths. Surveillance data on influenza virus activity permitted inference on influenza-associated hospitalizations and deaths. The ratios of these estimates were used as a potential indicator of severity. Influenza was associated with 431 (95% CrI: 358-503) respiratory deaths and 12,700 (95% CrI: 11,700-13,700) respiratory hospitalizations per year...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416961/predictive-factors-of-methicillin-resistant-staphylococcus-aureus-infection-in-elderly-patients-with-community-onset-pneumonia
#20
Hyeyoung Jwa, Jong Wook Beom, Jong Hoo Lee
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a severe and life-threatening disease in patients with community-onset (CO) pneumonia. However, the current guidelines lack specificity for a screening test for MRSA infection. METHODS: This study was retrospectively conducted in elderly patients aged ≥65 years, who had contracted CO-pneumonia during hospitalization at the Jeju National University Hospital, between January 2012 and December 2014...
April 2017: Tuberculosis and Respiratory Diseases
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